TDMS Study 88127-06 Pathology Tables
NTP Experiment-Test: 88127-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SUBCHRON 26-WEEK PENTAERYTHRITOL TRIACRYLATE (PETA) Date: 01/10/01
Route: SKIN APPLICATION Time: 08:15:23
Final #1/Mice
Facility: Battelle Columbus Laboratory
Chemical CAS #: 3524-68-3
Lock Date: 06/16/99
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 88127-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SUBCHRON 26-WEEK PENTAERYTHRITOL TRIACRYLATE (PETA) Date: 01/10/01
Route: SKIN APPLICATION Time: 08:15:23
____________________________________________________________________________________________________________________________________
MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 15 15 15 15 15 15
Early Deaths
Natural Death 2 3 3 2 3
Moribund Sacrifice 1 1 3
Survivors
Terminal Sacrifice 12 14 12 12 13 9
Animals Examined Microscopically 15 15 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (15) (15) (15) (15) (15) (15)
Leukemia Erythrocytic 1 (7%) 1 (7%)
Salivary Glands (1)
Carcinoma 1 (100%)
Stomach, Forestomach (15) (15) (15) (15) (15) (15)
Squamous Cell Papilloma 2 (13%) 4 (27%) 5 (33%) 4 (27%) 6 (40%) 3 (20%)
Squamous Cell Papilloma, Multiple 3 (20%) 3 (20%) 1 (7%) 1 (7%)
Tooth (4) (3) (3) (1)
Odontogenic Tumor 4 (100%) 3 (100%) 2 (67%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (15) (15) (15) (15) (15) (15)
Leukemia Erythrocytic 1 (7%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (15) (15) (15)
Leukemia Erythrocytic 1 (7%) 1 (7%)
Adrenal Medulla (15) (15) (15) (14) (15) (15)
Leukemia Erythrocytic 1 (7%) 1 (7%)
Pheochromocytoma Benign 1 (7%)
Pituitary Gland (15) (15) (14) (15) (15) (15)
Leukemia Erythrocytic 1 (7%) 1 (7%)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 88127-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SUBCHRON 26-WEEK PENTAERYTHRITOL TRIACRYLATE (PETA) Date: 01/10/01
Route: SKIN APPLICATION Time: 08:15:23
____________________________________________________________________________________________________________________________________
MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (15) (15) (15) (15) (15) (15)
Leukemia Erythrocytic 1 (7%) 1 (7%)
Uterus (15) (15) (15) (15) (15) (15)
Leukemia Erythrocytic 1 (7%)
Vagina (1)
Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (15) (14) (13) (12) (15) (14)
Mediastinal, Leukemia Erythrocytic 1 (7%)
Lymph Node, Mandibular (15) (15) (15) (15) (15) (13)
Leukemia Erythrocytic 1 (7%) 1 (8%)
Lymph Node, Mesenteric (14) (15) (15) (14) (15) (15)
Leukemia Erythrocytic 1 (7%) 1 (7%)
Spleen (15) (15) (15) (15) (15) (15)
Leukemia Erythrocytic 1 (7%) 1 (7%)
Thymus (15) (15) (15) (14) (14) (15)
Lymphoma Malignant 1 (7%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (15) (15) (15) (15) (15) (15)
Squamous Cell Papilloma, Multiple 1 (7%)
Skin, Site of Application, Keratoacanthoma 1 (7%)
Skin, Site of Application, Squamous Cell
Carcinoma 1 (7%)
Skin, Site of Application, Squamous Cell
Papilloma 3 (20%)
Skin, Site of Application, Squamous Cell
Papilloma, Multiple 1 (7%) 7 (47%) 12 (80%) 13 (87%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 88127-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SUBCHRON 26-WEEK PENTAERYTHRITOL TRIACRYLATE (PETA) Date: 01/10/01
Route: SKIN APPLICATION Time: 08:15:23
____________________________________________________________________________________________________________________________________
MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15) (15) (15)
Leukemia Erythrocytic 1 (7%) 1 (7%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15) (15) (15)
Leukemia Erythrocytic 1 (7%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(15) *(15) *(15) *(15) *(15) *(15)
Leukemia Erythrocytic 1 (7%) 1 (7%)
Lymphoma Malignant 1 (7%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 4
NTP Experiment-Test: 88127-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SUBCHRON 26-WEEK PENTAERYTHRITOL TRIACRYLATE (PETA) Date: 01/10/01
Route: SKIN APPLICATION Time: 08:15:23
____________________________________________________________________________________________________________________________________
MICE:TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 9 4 6 13 13 14
Total Primary Neoplasms 10 4 10 20 22 21
Total Animals with Benign Neoplasms 5 4 6 11 13 13
Total Benign Neoplasms 5 4 7 17 21 18
Total Animals with Malignant Neoplasms 1 1 3
Total Malignant Neoplasms 1 1 3
Total Animals with Metastatic Neoplasms
Total Metastatic Neoplasm
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 4 3 2 1
Total Uncertain Neoplasms 4 3 2 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 5
NTP Experiment-Test: 88127-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SUBCHRON 26-WEEK PENTAERYTHRITOL TRIACRYLATE (PETA) Date: 01/10/01
Route: SKIN APPLICATION Time: 08:15:23
____________________________________________________________________________________________________________________________________
MICE:TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 15 15 15 15 15 15
Early Deaths
Natural Death 3 2 5
Moribund Sacrifice 1 1
Survivors
Terminal Sacrifice 12 14 15 15 12 10
Animals Examined Microscopically 15 15 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (15) (15) (15) (15) (15) (15)
Leukemia Erythrocytic 1 (7%)
Salivary Glands (1) (1) (1) (1)
Carcinoma 1 (100%) 1 (100%) 1 (100%) 1 (100%)
Stomach, Forestomach (15) (15) (15) (15) (15) (15)
Squamous Cell Papilloma 2 (13%) 3 (20%) 5 (33%) 5 (33%) 5 (33%) 3 (20%)
Squamous Cell Papilloma, Multiple 4 (27%) 1 (7%) 3 (20%) 2 (13%)
Tooth (2) (3) (1) (3) (2)
Odontogenic Tumor 2 (100%) 3 (100%) 1 (100%) 3 (100%) 2 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 6
NTP Experiment-Test: 88127-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SUBCHRON 26-WEEK PENTAERYTHRITOL TRIACRYLATE (PETA) Date: 01/10/01
Route: SKIN APPLICATION Time: 08:15:23
____________________________________________________________________________________________________________________________________
MICE:TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Spleen (15) (15) (15) (15) (15) (15)
Leukemia Erythrocytic 1 (7%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (15) (15) (15) (15) (15) (15)
Squamous Cell Papilloma, Multiple 1 (7%)
Skin, Site of Application, Keratoacanthoma 2 (13%) 2 (13%) 2 (13%)
Skin, Site of Application, Keratoacanthoma,
Multiple 1 (7%) 4 (27%)
Skin, Site of Application, Squamous Cell
Carcinoma 2 (13%) 2 (13%)
Skin, Site of Application, Squamous Cell
Carcinoma, Multiple 1 (7%)
Skin, Site of Application, Squamous Cell
Papilloma 1 (7%) 4 (27%) 4 (27%)
Skin, Site of Application, Squamous Cell
Papilloma, Multiple 11 (73%) 15 (100%) 13 (87%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 88127-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SUBCHRON 26-WEEK PENTAERYTHRITOL TRIACRYLATE (PETA) Date: 01/10/01
Route: SKIN APPLICATION Time: 08:15:23
____________________________________________________________________________________________________________________________________
MICE:TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15) (15) (15)
Alveolar/Bronchiolar Adenoma 2 (13%) 1 (7%)
Carcinoma, Metastatic, Salivary Glands 1 (7%)
Leukemia Erythrocytic 1 (7%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15) (15) (15)
Leukemia Erythrocytic 1 (7%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(15) *(15) *(15) *(15) *(15) *(15)
Leukemia Erythrocytic 1 (7%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 8
NTP Experiment-Test: 88127-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SUBCHRON 26-WEEK PENTAERYTHRITOL TRIACRYLATE (PETA) Date: 01/10/01
Route: SKIN APPLICATION Time: 08:15:23
____________________________________________________________________________________________________________________________________
MICE:TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 9 5 9 15 15 13
Total Primary Neoplasms 12 6 12 29 26 32
Total Animals with Benign Neoplasms 7 5 8 15 15 13
Total Benign Neoplasms 9 5 9 25 23 25
Total Animals with Malignant Neoplasms 1 1 3 5
Total Malignant Neoplasms 1 1 3 5
Total Animals with Metastatic Neoplasms 1
Total Metastatic Neoplasm 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 2 3 1 3 2
Total Uncertain Neoplasms 2 3 1 3 2
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 9
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