TDMS Study 88127-06 Pathology Tables
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Battelle Columbus PENTAERYTHRITOL TRIACRYLATE (PETA) DATE: 07/12/02
EXPERIMENT: 88127 TEST: 06 TIME: 08:41:06
TEST TYPE: SUBCHRON 26-WEEK PAGE: 1
CONT: NO1-ES-65406 ROUTE: SKIN APPLICATION NTP C#: 88127B
PATHOLOGIST: TOFT, JOHN CAS: 3524-68-3
------------------------------------------------------------------------------------------------------------------------------------
Final#2
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Battelle Columbus PENTAERYTHRITOL TRIACRYLATE (PETA) DATE: 07/12/02
EXPERIMENT: 88127 TEST: 06 TIME: 08:41:06
TEST TYPE: SUBCHRON 26-WEEK
CONT: NO1-ES-65406 ROUTE: SKIN APPLICATION NTP C#: 88127B
PATHOLOGIST: TOFT, JOHN CAS: 3524-68-3
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF PENTAERYTHRITOL TRIACRYLATE (PETA)
===============================================================
Male Mice
------------
Organ Morphology
----- ----------
Adrenal Cortex Hypertrophy
Myelodysplasia
Adrenal Medulla Infiltration Cellular
Myelodysplasia
Epididymis Infiltration Cellular
Inflammation Chronic
Myelodysplasia
Heart Infiltration Cellular
Myelodysplasia
Kidney Infiltration Cellular
Myelodysplasia
Nephropathy
Liver Infiltration Cellular
Inflammation Chronic
Myelodysplasia
Lung Infiltration Cellular
Inflammation Chronic
Myelodysplasia
Lymph Node, Mandibular Infiltration Cellular
Infiltration Cellular Plasma Cell
Myelodysplasia
Lymph Node, Mesenteric Infiltration Cellular
Myelodysplasia
Lymph Node: Mediastinal Infiltration Cellular
Skin: Epidermis, Skin, Site of Application
Hyperplasia
Skin: Skin, Site of Application Hyperkeratosis
Inflammation Chronic
Spleen Depletion Cellular
Hematopoietic Cell Proliferation
Infiltration Cellular
Myelodysplasia
Stomach, Forestomach Hyperkeratosis
Testes: Unilateral, Germinal Epithelium
Degeneration
Thymus Atrophy
Myelodysplasia
===============================================================
Female Mice
------------
Organ Morphology
----- ----------
Adrenal Cortex: Capsule Hyperplasia
Kidney: Cortex Cyst
Kidney: Renal Tubule Necrosis
Liver Hematopoietic Cell Proliferation
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Battelle Columbus PENTAERYTHRITOL TRIACRYLATE (PETA) DATE: 07/12/02
EXPERIMENT: 88127 TEST: 06 TIME: 08:41:06
TEST TYPE: SUBCHRON 26-WEEK
CONT: NO1-ES-65406 ROUTE: SKIN APPLICATION NTP C#: 88127B
PATHOLOGIST: TOFT, JOHN CAS: 3524-68-3
Infiltration Cellular
Pigmentation
Lymph Node Hematopoietic Cell Proliferation
Lymph Node, Mandibular Hematopoietic Cell Proliferation
Infiltration Cellular
Lymph Node: Mediastinal Infiltration Cellular
Skin: Epidermis, Skin, Site of Application
Hyperplasia
Skin: Skin, Site of Application Hyperkeratosis
Inflammation Chronic
Spleen Hematopoietic Cell Proliferation
Stomach, Forestomach Hyperkeratosis
Thymus Atrophy
Thymus: Thymocyte Necrosis
===============================================================
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 1
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE
(PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Hypertrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 7/15 (47%) 10/15 (67%) 3/15 (20%) 5/15 (33%) 1/15 (7%) 3/15 (20%) |
|POLY-3 RATE (b) | 7/13.43 10/14.34 3/15.00 5/15.00 1/14.39 3/13.53 |
|POLY-3 PERCENT (g) | 52.1% 69.7% 20.0% 33.3% 7.0% 22.2% |
|TERMINAL (d) | 7/12 (58%) 10/14 (71%) 3/15 (20%) 5/15 (33%) 1/12 (8%) 3/10 (30%) |
|FIRST INCIDENCE | 185 (T) 185 (T) 185 (T) 185 (T) 185 (T) 185 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.040N* P=0.389 P=0.053N P=0.186N P=0.017N* P=0.190N |
|POLY 3 | P=0.010N* P=0.285 P=0.076N P=0.266N P=0.007N** P=0.106N |
|POLY 1.5 | P=0.009N** P=0.258 P=0.093N P=0.303N P=0.009N** P=0.111N |
|POLY 6 | P=0.011N* P=0.329 P=0.059N P=0.224N P=0.005N** P=0.106N |
|LOGISTIC REGRESSION| P=0.040N* P=0.389 P=0.053N P=0.186N P=0.017N* P=0.190N |
|COCH-ARM / FISHERS | P=0.013N* P=0.231 P=0.123N P=0.355N P=0.018N* P=0.123N |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Hypertrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) |
|POLY-3 RATE (b) | 0/12.95 0/14.05 0/12.72 0/14.49 0/14.03 0/10.72 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/12 (0%) 0/12 (0%) 0/13 (0%) 0/9 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 2
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Myelodysplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 2/15 (13%) |
|POLY-3 RATE (b) | 0/13.43 0/14.34 0/15.00 0/15.00 0/14.39 2/13.53 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 14.8% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/15 (0%) 0/15 (0%) 0/12 (0%) 2/10 (20%) |
|FIRST INCIDENCE | --- --- --- --- --- 185 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.004 ** (e) (e) (e) (e) P=0.195 |
|POLY 3 | P=0.008 ** (e) (e) (e) (e) P=0.232 |
|POLY 1.5 | P=0.009 ** (e) (e) (e) (e) P=0.232 |
|POLY 6 | P=0.008 ** (e) (e) (e) (e) P=0.228 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) P=0.195 |
|COCH-ARM / FISHERS | P=0.011 * (e) (e) (e) (e) P=0.241 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Myelodysplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) |
|POLY-3 RATE (b) | 0/12.95 0/14.05 0/12.72 0/14.49 0/14.03 0/10.72 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/12 (0%) 0/12 (0%) 0/13 (0%) 0/9 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 3
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Adrenal Cortex: Capsule |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) |
|POLY-3 RATE (b) | 0/13.43 0/14.34 0/15.00 0/15.00 0/14.39 0/13.53 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/15 (0%) 0/15 (0%) 0/12 (0%) 0/10 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Adrenal Cortex: Capsule |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/15 (7%) 4/15 (27%) 7/15 (47%) 2/15 (13%) 1/15 (7%) 2/15 (13%) |
|POLY-3 RATE (b) | 1/12.95 4/14.05 7/12.72 2/14.77 1/14.94 2/11.35 |
|POLY-3 PERCENT (g) | 7.7% 28.5% 55.1% 13.5% 6.7% 17.6% |
|TERMINAL (d) | 1/12 (8%) 4/14 (29%) 7/12 (58%) 1/12 (8%) 0/13 (0%) 1/9 (11%) |
|FIRST INCIDENCE | 186 (T) 186 (T) 186 (T) 167 85 134 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.309N P=0.215 P=0.017 * P=0.517 P=0.735N P=0.414 |
|POLY 3 | P=0.193N P=0.187 P=0.008 ** P=0.546 P=0.728N P=0.452 |
|POLY 1.5 | P=0.189N P=0.181 P=0.009 ** P=0.538 P=0.735N P=0.470 |
|POLY 6 | P=0.200N P=0.191 P=0.007 ** P=0.547 P=0.725N P=0.434 |
|LOGISTIC REGRESSION| P=0.205N P=0.215 P=0.017 * P=0.518 P=0.698 P=0.482 |
|COCH-ARM / FISHERS | P=0.191N P=0.165 P=0.018 * P=0.500 P=0.759N P=0.500 |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 4
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Infiltration Cellular |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 2/15 (13%) |
|POLY-3 RATE (b) | 0/13.43 0/14.34 0/15.00 0/15.00 0/14.39 2/13.53 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 14.8% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/15 (0%) 0/15 (0%) 0/12 (0%) 2/10 (20%) |
|FIRST INCIDENCE | --- --- --- --- --- 185 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.004 ** (e) (e) (e) (e) P=0.195 |
|POLY 3 | P=0.008 ** (e) (e) (e) (e) P=0.232 |
|POLY 1.5 | P=0.009 ** (e) (e) (e) (e) P=0.232 |
|POLY 6 | P=0.008 ** (e) (e) (e) (e) P=0.228 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) P=0.195 |
|COCH-ARM / FISHERS | P=0.011 * (e) (e) (e) (e) P=0.241 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Infiltration Cellular |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/14 (0%) 0/15 (0%) 0/15 (0%) |
|POLY-3 RATE (b) | 0/12.95 0/14.05 0/12.72 0/13.63 0/14.03 0/10.72 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/12 (0%) 0/12 (0%) 0/13 (0%) 0/9 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 5
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Myelodysplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 2/15 (13%) |
|POLY-3 RATE (b) | 0/13.43 0/14.34 0/15.00 0/15.00 0/14.39 2/13.53 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 14.8% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/15 (0%) 0/15 (0%) 0/12 (0%) 2/10 (20%) |
|FIRST INCIDENCE | --- --- --- --- --- 185 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.004 ** (e) (e) (e) (e) P=0.195 |
|POLY 3 | P=0.008 ** (e) (e) (e) (e) P=0.232 |
|POLY 1.5 | P=0.009 ** (e) (e) (e) (e) P=0.232 |
|POLY 6 | P=0.008 ** (e) (e) (e) (e) P=0.228 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) P=0.195 |
|COCH-ARM / FISHERS | P=0.011 * (e) (e) (e) (e) P=0.241 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Myelodysplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/14 (0%) 0/15 (0%) 0/15 (0%) |
|POLY-3 RATE (b) | 0/12.95 0/14.05 0/12.72 0/13.63 0/14.03 0/10.72 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/12 (0%) 0/12 (0%) 0/13 (0%) 0/9 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 6
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Epididymis |
| Infiltration Cellular |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/14 (0%) 0/15 (0%) 0/15 (0%) 5/15 (33%) 5/15 (33%) |
|POLY-3 RATE (b) | 0/13.43 0/13.34 0/15.00 0/15.00 5/14.39 5/13.53 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 34.8% 37.0% |
|TERMINAL (d) | 0/12 (0%) 0/13 (0%) 0/15 (0%) 0/15 (0%) 5/12 (42%) 5/10 (50%) |
|FIRST INCIDENCE | --- --- --- --- 185 (T) 185 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) P=0.025 * P=0.013 * |
|POLY 3 | P<0.001 ** (e) (e) (e) P=0.021 * P=0.016 * |
|POLY 1.5 | P<0.001 ** (e) (e) (e) P=0.019 * P=0.016 * |
|POLY 6 | P<0.001 ** (e) (e) (e) P=0.022 * P=0.014 * |
|LOGISTIC REGRESSION| (e) (e) (e) (e) P=0.025 * P=0.013 * |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) (e) P=0.021 * P=0.021 * |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Epididymis |
| Infiltration Cellular |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | |
|POLY-3 RATE (b) | |
|POLY-3 PERCENT (g) | |
|TERMINAL (d) | |
|FIRST INCIDENCE | |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | |
|POLY 3 | |
|POLY 1.5 | |
|POLY 6 | |
|LOGISTIC REGRESSION| |
|COCH-ARM / FISHERS | |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 7
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Epididymis |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 1/14 (7%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 4/15 (27%) |
|POLY-3 RATE (b) | 0/13.43 1/13.34 0/15.00 0/15.00 0/14.39 4/14.51 |
|POLY-3 PERCENT (g) | 0.0% 7.5% 0.0% 0.0% 0.0% 27.6% |
|TERMINAL (d) | 0/12 (0%) 1/13 (8%) 0/15 (0%) 0/15 (0%) 0/12 (0%) 1/10 (10%) |
|FIRST INCIDENCE | --- 185 (T) --- --- --- 138 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** P=0.516 (e) (e) (e) P=0.065 |
|POLY 3 | P<0.001 ** P=0.499 (e) (e) (e) P=0.054 |
|POLY 1.5 | P<0.001 ** P=0.493 (e) (e) (e) P=0.050 |
|POLY 6 | P<0.001 ** P=0.506 (e) (e) (e) P=0.057 |
|LOGISTIC REGRESSION| P=0.003 ** P=0.516 (e) (e) (e) P=0.036 * |
|COCH-ARM / FISHERS | P=0.002 ** P=0.483 (e) (e) (e) P=0.050 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Epididymis |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | |
|POLY-3 RATE (b) | |
|POLY-3 PERCENT (g) | |
|TERMINAL (d) | |
|FIRST INCIDENCE | |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | |
|POLY 3 | |
|POLY 1.5 | |
|POLY 6 | |
|LOGISTIC REGRESSION| |
|COCH-ARM / FISHERS | |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 8
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Epididymis |
| Myelodysplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/14 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 5/15 (33%) |
|POLY-3 RATE (b) | 0/13.43 0/13.34 0/15.00 0/15.00 0/14.39 5/13.53 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 37.0% |
|TERMINAL (d) | 0/12 (0%) 0/13 (0%) 0/15 (0%) 0/15 (0%) 0/12 (0%) 5/10 (50%) |
|FIRST INCIDENCE | --- --- --- --- --- 185 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) (e) P=0.013 * |
|POLY 3 | P<0.001 ** (e) (e) (e) (e) P=0.016 * |
|POLY 1.5 | P<0.001 ** (e) (e) (e) (e) P=0.016 * |
|POLY 6 | P<0.001 ** (e) (e) (e) (e) P=0.014 * |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) P=0.013 * |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) (e) (e) P=0.021 * |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Epididymis |
| Myelodysplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | |
|POLY-3 RATE (b) | |
|POLY-3 PERCENT (g) | |
|TERMINAL (d) | |
|FIRST INCIDENCE | |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | |
|POLY 3 | |
|POLY 1.5 | |
|POLY 6 | |
|LOGISTIC REGRESSION| |
|COCH-ARM / FISHERS | |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 9
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Epididymis: Unilateral |
| Hypospermia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/15 (7%) 1/14 (7%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 2/15 (13%) |
|POLY-3 RATE (b) | 1/13.95 1/13.34 0/15.00 0/15.00 0/14.39 2/13.79 |
|POLY-3 PERCENT (g) | 7.2% 7.5% 0.0% 0.0% 0.0% 14.5% |
|TERMINAL (d) | 0/12 (0%) 1/13 (8%) 0/15 (0%) 0/15 (0%) 0/12 (0%) 1/10 (10%) |
|FIRST INCIDENCE | 145 185 (T) --- --- --- 167 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.182 P=0.751N P=0.486N P=0.486N P=0.486N P=0.488 |
|POLY 3 | P=0.215 P=0.751 P=0.486N P=0.486N P=0.494N P=0.496 |
|POLY 1.5 | P=0.220 P=0.748 P=0.491N P=0.491N P=0.496N P=0.498 |
|POLY 6 | P=0.209 P=0.755 P=0.479N P=0.479N P=0.493N P=0.490 |
|LOGISTIC REGRESSION| P=0.241 P=0.720 P=0.981N P=0.981N P=0.928N P=0.460 |
|COCH-ARM / FISHERS | P=0.224 P=0.741 P=0.500N P=0.500N P=0.500N P=0.500 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Epididymis: Unilateral |
| Hypospermia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | |
|POLY-3 RATE (b) | |
|POLY-3 PERCENT (g) | |
|TERMINAL (d) | |
|FIRST INCIDENCE | |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | |
|POLY 3 | |
|POLY 1.5 | |
|POLY 6 | |
|LOGISTIC REGRESSION| |
|COCH-ARM / FISHERS | |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 10
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Heart |
| Infiltration Cellular |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 3/15 (20%) |
|POLY-3 RATE (b) | 0/13.43 0/14.34 0/15.00 0/15.00 0/14.39 3/13.53 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 22.2% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/15 (0%) 0/15 (0%) 0/12 (0%) 3/10 (30%) |
|FIRST INCIDENCE | --- --- --- --- --- 185 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) (e) P=0.083 |
|POLY 3 | P<0.001 ** (e) (e) (e) (e) P=0.105 |
|POLY 1.5 | P<0.001 ** (e) (e) (e) (e) P=0.106 |
|POLY 6 | P<0.001 ** (e) (e) (e) (e) P=0.102 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) P=0.083 |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) (e) (e) P=0.112 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Heart |
| Infiltration Cellular |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 1/15 (7%) |
|POLY-3 RATE (b) | 0/12.95 0/14.05 0/12.72 0/14.49 0/14.03 1/10.72 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 9.3% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/12 (0%) 0/12 (0%) 0/13 (0%) 1/9 (11%) |
|FIRST INCIDENCE | --- --- --- --- --- 186 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.073 (e) (e) (e) (e) P=0.443 |
|POLY 3 | P=0.090 (e) (e) (e) (e) P=0.462 |
|POLY 1.5 | P=0.095 (e) (e) (e) (e) P=0.477 |
|POLY 6 | P=0.085 (e) (e) (e) (e) P=0.447 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) P=0.443 |
|COCH-ARM / FISHERS | P=0.105 (e) (e) (e) (e) P=0.500 |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 11
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Heart |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 3/15 (20%) 0/15 (0%) 0/15 (0%) 1/15 (7%) 0/15 (0%) |
|POLY-3 RATE (b) | 0/13.43 3/14.34 0/15.00 0/15.00 1/14.41 0/13.53 |
|POLY-3 PERCENT (g) | 0.0% 20.9% 0.0% 0.0% 6.9% 0.0% |
|TERMINAL (d) | 0/12 (0%) 3/14 (21%) 0/15 (0%) 0/15 (0%) 0/12 (0%) 0/10 (0%) |
|FIRST INCIDENCE | --- 185 (T) --- --- 184 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.363N P=0.143 (e) (e) P=0.516 (e) |
|POLY 3 | P=0.295N P=0.117 (e) (e) P=0.514 (e) |
|POLY 1.5 | P=0.294N P=0.112 (e) (e) P=0.509 (e) |
|POLY 6 | P=0.298N P=0.125 (e) (e) P=0.519 (e) |
|LOGISTIC REGRESSION| P=0.332N P=0.143 (e) (e) P=0.520 (e) |
|COCH-ARM / FISHERS | P=0.299N P=0.112 (e) (e) P=0.500 (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Heart |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 1/15 (7%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 1/15 (7%) |
|POLY-3 RATE (b) | 0/12.95 1/14.05 0/12.72 0/14.49 0/14.03 1/10.72 |
|POLY-3 PERCENT (g) | 0.0% 7.1% 0.0% 0.0% 0.0% 9.3% |
|TERMINAL (d) | 0/12 (0%) 1/14 (7%) 0/12 (0%) 0/12 (0%) 0/13 (0%) 1/9 (11%) |
|FIRST INCIDENCE | --- 186 (T) --- --- --- 186 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.300 P=0.531 (e) (e) (e) P=0.443 |
|POLY 3 | P=0.346 P=0.516 (e) (e) (e) P=0.462 |
|POLY 1.5 | P=0.353 P=0.512 (e) (e) (e) P=0.477 |
|POLY 6 | P=0.341 P=0.519 (e) (e) (e) P=0.447 |
|LOGISTIC REGRESSION| (e) P=0.531 (e) (e) (e) P=0.443 |
|COCH-ARM / FISHERS | P=0.364 P=0.500 (e) (e) (e) P=0.500 |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 12
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Heart |
| Myelodysplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 3/15 (20%) |
|POLY-3 RATE (b) | 0/13.43 0/14.34 0/15.00 0/15.00 0/14.39 3/13.53 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 22.2% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/15 (0%) 0/15 (0%) 0/12 (0%) 3/10 (30%) |
|FIRST INCIDENCE | --- --- --- --- --- 185 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) (e) P=0.083 |
|POLY 3 | P<0.001 ** (e) (e) (e) (e) P=0.105 |
|POLY 1.5 | P<0.001 ** (e) (e) (e) (e) P=0.106 |
|POLY 6 | P<0.001 ** (e) (e) (e) (e) P=0.102 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) P=0.083 |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) (e) (e) P=0.112 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Heart |
| Myelodysplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) |
|POLY-3 RATE (b) | 0/12.95 0/14.05 0/12.72 0/14.49 0/14.03 0/10.72 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/12 (0%) 0/12 (0%) 0/13 (0%) 0/9 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 13
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Kidney |
| Infarct |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 1/15 (7%) 2/15 (13%) 0/15 (0%) 0/15 (0%) |
|POLY-3 RATE (b) | 0/13.43 0/14.34 1/15.00 2/15.00 0/14.39 0/13.53 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 6.7% 13.3% 0.0% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 1/15 (7%) 2/15 (13%) 0/12 (0%) 0/10 (0%) |
|FIRST INCIDENCE | --- --- 185 (T) 185 (T) --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.507N (e) P=0.545 P=0.286 (e) (e) |
|POLY 3 | P=0.430N (e) P=0.522 P=0.257 (e) (e) |
|POLY 1.5 | P=0.431N (e) P=0.513 P=0.246 (e) (e) |
|POLY 6 | P=0.433N (e) P=0.533 P=0.271 (e) (e) |
|LOGISTIC REGRESSION| (e) (e) P=0.545 P=0.286 (e) (e) |
|COCH-ARM / FISHERS | P=0.436N (e) P=0.500 P=0.241 (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Kidney |
| Infarct |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) |
|POLY-3 RATE (b) | 0/12.95 0/14.05 0/12.72 0/14.49 0/14.03 0/10.72 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/12 (0%) 0/12 (0%) 0/13 (0%) 0/9 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 14
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Kidney |
| Infiltration Cellular |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 2/15 (13%) 3/15 (20%) |
|POLY-3 RATE (b) | 0/13.43 0/14.34 0/15.00 0/15.00 2/14.39 3/13.53 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 13.9% 22.2% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/15 (0%) 0/15 (0%) 2/12 (17%) 3/10 (30%) |
|FIRST INCIDENCE | --- --- --- --- 185 (T) 185 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) P=0.235 P=0.083 |
|POLY 3 | P<0.001 ** (e) (e) (e) P=0.247 P=0.105 |
|POLY 1.5 | P<0.001 ** (e) (e) (e) P=0.241 P=0.106 |
|POLY 6 | P<0.001 ** (e) (e) (e) P=0.253 P=0.102 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) P=0.235 P=0.083 |
|COCH-ARM / FISHERS | P=0.002 ** (e) (e) (e) P=0.241 P=0.112 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Kidney |
| Infiltration Cellular |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) |
|POLY-3 RATE (b) | 0/12.95 0/14.05 0/12.72 0/14.49 0/14.03 0/10.72 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/12 (0%) 0/12 (0%) 0/13 (0%) 0/9 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 15
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Kidney |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/15 (7%) 0/15 (0%) 4/15 (27%) 4/15 (27%) 3/15 (20%) 0/15 (0%) |
|POLY-3 RATE (b) | 1/13.43 0/14.34 4/15.00 4/15.00 3/14.39 0/13.53 |
|POLY-3 PERCENT (g) | 7.4% 0.0% 26.7% 26.7% 20.9% 0.0% |
|TERMINAL (d) | 1/12 (8%) 0/14 (0%) 4/15 (27%) 4/15 (27%) 3/12 (25%) 0/10 (0%) |
|FIRST INCIDENCE | 185 (T) --- 185 (T) 185 (T) 185 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.417N P=0.469N P=0.240 P=0.240 P=0.296 P=0.536N |
|POLY 3 | P=0.297N P=0.487N P=0.198 P=0.198 P=0.323 P=0.499N |
|POLY 1.5 | P=0.287N P=0.493N P=0.183 P=0.183 P=0.313 P=0.499N |
|POLY 6 | P=0.319N P=0.479N P=0.218 P=0.218 P=0.332 P=0.501N |
|LOGISTIC REGRESSION| P=0.417N (e) P=0.240 P=0.240 P=0.296 (e) |
|COCH-ARM / FISHERS | P=0.286N P=0.500N P=0.165 P=0.165 P=0.299 P=0.500N |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Kidney |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/15 (7%) 2/15 (13%) 1/15 (7%) 1/15 (7%) 1/15 (7%) 1/15 (7%) |
|POLY-3 RATE (b) | 1/12.95 2/14.05 1/13.51 1/14.49 1/14.03 1/10.72 |
|POLY-3 PERCENT (g) | 7.7% 14.2% 7.4% 6.9% 7.1% 9.3% |
|TERMINAL (d) | 1/12 (8%) 2/14 (14%) 0/12 (0%) 1/12 (8%) 1/13 (8%) 1/9 (11%) |
|FIRST INCIDENCE | 186 (T) 186 (T) 109 186 (T) 186 (T) 186 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.593N P=0.555 P=0.752N P=0.765 P=0.747N P=0.700 |
|POLY 3 | P=0.528N P=0.529 P=0.752N P=0.736N P=0.743N P=0.718 |
|POLY 1.5 | P=0.517N P=0.522 P=0.755N P=0.739N P=0.746N P=0.736 |
|POLY 6 | P=0.534N P=0.533 P=0.753N P=0.739N P=0.742N P=0.699 |
|LOGISTIC REGRESSION| P=0.508N P=0.555 P=0.760N P=0.765 P=0.747N P=0.700 |
|COCH-ARM / FISHERS | P=0.495N P=0.500 P=0.759N P=0.759N P=0.759N P=0.759N |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 16
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Kidney |
| Myelodysplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 4/15 (27%) |
|POLY-3 RATE (b) | 0/13.43 0/14.34 0/15.00 0/15.00 0/14.39 4/13.53 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 29.6% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/15 (0%) 0/15 (0%) 0/12 (0%) 4/10 (40%) |
|FIRST INCIDENCE | --- --- --- --- --- 185 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) (e) P=0.034 * |
|POLY 3 | P<0.001 ** (e) (e) (e) (e) P=0.043 * |
|POLY 1.5 | P<0.001 ** (e) (e) (e) (e) P=0.045 * |
|POLY 6 | P<0.001 ** (e) (e) (e) (e) P=0.041 * |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) P=0.034 * |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) (e) (e) P=0.050 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Kidney |
| Myelodysplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) |
|POLY-3 RATE (b) | 0/12.95 0/14.05 0/12.72 0/14.49 0/14.03 0/10.72 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/12 (0%) 0/12 (0%) 0/13 (0%) 0/9 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 17
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Kidney |
| Nephropathy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 6/15 (40%) 1/15 (7%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) |
|POLY-3 RATE (b) | 6/13.43 1/15.00 0/15.00 0/15.00 0/14.39 0/13.53 |
|POLY-3 PERCENT (g) | 44.7% 6.7% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 6/12 (50%) 0/14 (0%) 0/15 (0%) 0/15 (0%) 0/12 (0%) 0/10 (0%) |
|FIRST INCIDENCE | 185 (T) 129 --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.017N* P=0.032N* P=0.005N** P=0.005N** P=0.011N* P=0.018N* |
|POLY 3 | P=0.007N** P=0.020N* P=0.003N** P=0.003N** P=0.003N** P=0.004N** |
|POLY 1.5 | P=0.006N** P=0.025N* P=0.003N** P=0.003N** P=0.004N** P=0.005N** |
|POLY 6 | P=0.008N** P=0.015N* P=0.002N** P=0.002N** P=0.002N** P=0.004N** |
|LOGISTIC REGRESSION| P=0.013N* P=0.045N* (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.013N* P=0.040N* P=0.008N** P=0.008N** P=0.008N** P=0.008N** |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Kidney |
| Nephropathy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/15 (20%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 2/15 (13%) |
|POLY-3 RATE (b) | 3/12.95 0/14.05 0/12.72 0/14.49 0/14.03 2/10.72 |
|POLY-3 PERCENT (g) | 23.2% 0.0% 0.0% 0.0% 0.0% 18.7% |
|TERMINAL (d) | 3/12 (25%) 0/14 (0%) 0/12 (0%) 0/12 (0%) 0/13 (0%) 2/9 (22%) |
|FIRST INCIDENCE | 186 (T) --- --- --- --- 186 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.331 P=0.089N P=0.113N P=0.113N P=0.100N P=0.641N |
|POLY 3 | P=0.407 P=0.090N P=0.107N P=0.085N P=0.090N P=0.591N |
|POLY 1.5 | P=0.409 P=0.094N P=0.106N P=0.088N P=0.093N P=0.556N |
|POLY 6 | P=0.411 P=0.088N P=0.110N P=0.087N P=0.089N P=0.628N |
|LOGISTIC REGRESSION| P=0.331 (e) (e) (e) (e) P=0.641N |
|COCH-ARM / FISHERS | P=0.428 P=0.112N P=0.112N P=0.112N P=0.112N P=0.500N |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 18
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Kidney: Cortex |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 1/15 (7%) 0/15 (0%) 1/15 (7%) 1/15 (7%) 1/15 (7%) |
|POLY-3 RATE (b) | 0/13.43 1/15.00 0/15.00 1/15.00 1/14.39 1/13.53 |
|POLY-3 PERCENT (g) | 0.0% 6.7% 0.0% 6.7% 7.0% 7.4% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/15 (0%) 1/15 (7%) 1/12 (8%) 1/10 (10%) |
|FIRST INCIDENCE | --- 129 --- 185 (T) 185 (T) 185 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.279 P=0.500 (e) P=0.545 P=0.500 P=0.464 |
|POLY 3 | P=0.328 P=0.522 (e) P=0.522 P=0.514 P=0.501 |
|POLY 1.5 | P=0.337 P=0.513 (e) P=0.513 P=0.508 P=0.501 |
|POLY 6 | P=0.312 P=0.533 (e) P=0.533 P=0.519 P=0.499 |
|LOGISTIC REGRESSION| P=0.360 (e) (e) P=0.545 P=0.500 P=0.464 |
|COCH-ARM / FISHERS | P=0.343 P=0.500 (e) P=0.500 P=0.500 P=0.500 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Kidney: Cortex |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 2/15 (13%) |
|POLY-3 RATE (b) | 0/12.95 0/14.05 0/12.72 0/14.49 0/14.03 2/11.50 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 17.4% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/12 (0%) 0/12 (0%) 0/13 (0%) 1/9 (11%) |
|FIRST INCIDENCE | --- --- --- --- --- 113 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.007 ** (e) (e) (e) (e) P=0.208 |
|POLY 3 | P=0.008 ** (e) (e) (e) (e) P=0.202 |
|POLY 1.5 | P=0.008 ** (e) (e) (e) (e) P=0.213 |
|POLY 6 | P=0.008 ** (e) (e) (e) (e) P=0.191 |
|LOGISTIC REGRESSION| P=0.018 * (e) (e) (e) (e) P=0.248 |
|COCH-ARM / FISHERS | P=0.011 * (e) (e) (e) (e) P=0.241 |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 19
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) |
|POLY-3 RATE (b) | 0/13.43 0/14.34 0/15.00 0/15.00 0/14.39 0/13.53 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/15 (0%) 0/15 (0%) 0/12 (0%) 0/10 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 2/15 (13%) |
|POLY-3 RATE (b) | 0/12.95 0/14.05 0/12.72 0/14.49 0/14.03 2/11.91 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 16.8% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/12 (0%) 0/12 (0%) 0/13 (0%) 0/9 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- 98 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.008 ** (e) (e) (e) (e) P=0.219 |
|POLY 3 | P=0.008 ** (e) (e) (e) (e) P=0.210 |
|POLY 1.5 | P=0.009 ** (e) (e) (e) (e) P=0.218 |
|POLY 6 | P=0.008 ** (e) (e) (e) (e) P=0.202 |
|LOGISTIC REGRESSION| P=0.022 * (e) (e) (e) (e) P=0.269 |
|COCH-ARM / FISHERS | P=0.011 * (e) (e) (e) (e) P=0.241 |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 20
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Regeneration |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/15 (7%) 2/15 (13%) 0/15 (0%) 3/15 (20%) 0/15 (0%) 0/15 (0%) |
|POLY-3 RATE (b) | 1/13.43 2/14.34 0/15.00 3/15.00 0/14.39 0/13.53 |
|POLY-3 PERCENT (g) | 7.4% 14.0% 0.0% 20.0% 0.0% 0.0% |
|TERMINAL (d) | 1/12 (8%) 2/14 (14%) 0/15 (0%) 3/15 (20%) 0/12 (0%) 0/10 (0%) |
|FIRST INCIDENCE | 185 (T) 185 (T) --- 185 (T) --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.208N P=0.555 P=0.455N P=0.383 P=0.500N P=0.536N |
|POLY 3 | P=0.159N P=0.523 P=0.478N P=0.340 P=0.486N P=0.499N |
|POLY 1.5 | P=0.156N P=0.513 P=0.487N P=0.322 P=0.492N P=0.499N |
|POLY 6 | P=0.166N P=0.537 P=0.467N P=0.362 P=0.481N P=0.501N |
|LOGISTIC REGRESSION| P=0.208N P=0.555 (e) P=0.383 (e) (e) |
|COCH-ARM / FISHERS | P=0.158N P=0.500 P=0.500N P=0.299 P=0.500N P=0.500N |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Regeneration |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/15 (7%) 1/15 (7%) 0/15 (0%) 2/15 (13%) 1/15 (7%) 0/15 (0%) |
|POLY-3 RATE (b) | 1/12.95 1/14.05 0/12.72 2/14.49 1/14.03 0/10.72 |
|POLY-3 PERCENT (g) | 7.7% 7.1% 0.0% 13.8% 7.1% 0.0% |
|TERMINAL (d) | 1/12 (8%) 1/14 (7%) 0/12 (0%) 2/12 (17%) 1/13 (8%) 0/9 (0%) |
|FIRST INCIDENCE | 186 (T) 186 (T) --- 186 (T) 186 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.421N P=0.730N P=0.500N P=0.500 P=0.747N P=0.557N |
|POLY 3 | P=0.389N P=0.743N P=0.504N P=0.540 P=0.743N P=0.538N |
|POLY 1.5 | P=0.372N P=0.747N P=0.503N P=0.535 P=0.746N P=0.523N |
|POLY 6 | P=0.405N P=0.740N P=0.507N P=0.536 P=0.742N P=0.553N |
|LOGISTIC REGRESSION| P=0.421N P=0.730N (e) P=0.500 P=0.747N (e) |
|COCH-ARM / FISHERS | P=0.343N P=0.759N P=0.500N P=0.500 P=0.759N P=0.500N |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 21
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Liver |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 2/15 (13%) 0/15 (0%) |
|POLY-3 RATE (b) | 0/13.43 0/14.34 0/15.00 0/15.00 2/14.39 0/13.53 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 13.9% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/15 (0%) 0/15 (0%) 2/12 (17%) 0/10 (0%) |
|FIRST INCIDENCE | --- --- --- --- 185 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.348 (e) (e) (e) P=0.235 (e) |
|POLY 3 | P=0.373 (e) (e) (e) P=0.247 (e) |
|POLY 1.5 | P=0.391 (e) (e) (e) P=0.241 (e) |
|POLY 6 | P=0.343 (e) (e) (e) P=0.253 (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) P=0.235 (e) |
|COCH-ARM / FISHERS | P=0.414 (e) (e) (e) P=0.241 (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Liver |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 1/15 (7%) 1/15 (7%) 6/15 (40%) |
|POLY-3 RATE (b) | 0/12.95 0/14.05 0/12.72 1/14.59 1/14.03 6/10.72 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 6.9% 7.1% 56.0% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/12 (0%) 0/12 (0%) 1/13 (8%) 6/9 (67%) |
|FIRST INCIDENCE | --- --- --- 180 186 (T) 186 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) P=0.516 P=0.516 P=0.003 ** |
|POLY 3 | P<0.001 ** (e) (e) P=0.524 P=0.516 P<0.001 ** |
|POLY 1.5 | P<0.001 ** (e) (e) P=0.520 P=0.513 P=0.002 ** |
|POLY 6 | P<0.001 ** (e) (e) P=0.522 P=0.517 P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** (e) (e) P=0.511 P=0.516 P=0.003 ** |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) P=0.500 P=0.500 P=0.008 ** |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 22
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Liver |
| Infiltration Cellular |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 5/15 (33%) 3/15 (20%) |
|POLY-3 RATE (b) | 0/13.43 0/14.34 0/15.00 0/15.00 5/14.39 3/13.53 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 34.8% 22.2% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/15 (0%) 0/15 (0%) 5/12 (42%) 3/10 (30%) |
|FIRST INCIDENCE | --- --- --- --- 185 (T) 185 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) P=0.025 * P=0.083 |
|POLY 3 | P<0.001 ** (e) (e) (e) P=0.021 * P=0.105 |
|POLY 1.5 | P<0.001 ** (e) (e) (e) P=0.019 * P=0.106 |
|POLY 6 | P<0.001 ** (e) (e) (e) P=0.022 * P=0.102 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) P=0.025 * P=0.083 |
|COCH-ARM / FISHERS | P=0.002 ** (e) (e) (e) P=0.021 * P=0.112 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Liver |
| Infiltration Cellular |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 3/15 (20%) 2/15 (13%) |
|POLY-3 RATE (b) | 0/12.95 0/14.05 0/12.72 0/14.49 3/14.03 2/10.72 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 21.4% 18.7% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/12 (0%) 0/12 (0%) 3/13 (23%) 2/9 (22%) |
|FIRST INCIDENCE | --- --- --- --- 186 (T) 186 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.004 ** (e) (e) (e) P=0.128 P=0.173 |
|POLY 3 | P=0.004 ** (e) (e) (e) P=0.120 P=0.188 |
|POLY 1.5 | P=0.006 ** (e) (e) (e) P=0.117 P=0.203 |
|POLY 6 | P=0.003 ** (e) (e) (e) P=0.121 P=0.172 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) P=0.128 P=0.173 |
|COCH-ARM / FISHERS | P=0.014 * (e) (e) (e) P=0.112 P=0.241 |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 23
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Liver |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 5/15 (33%) 11/15 (73%) 10/15 (67%) 13/15 (87%) 13/15 (87%) 5/15 (33%) |
|POLY-3 RATE (b) | 5/13.43 11/15.00 10/15.00 13/15.00 13/14.67 5/14.19 |
|POLY-3 PERCENT (g) | 37.2% 73.3% 66.7% 86.7% 88.6% 35.2% |
|TERMINAL (d) | 5/12 (42%) 10/14 (71%) 10/15 (67%) 13/15 (87%) 12/12 (100%) 2/10 (20%) |
|FIRST INCIDENCE | 185 (T) 129 185 (T) 185 (T) 166 160 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.540 P=0.081 P=0.186 P=0.022 * P=0.003 ** P=0.562 |
|POLY 3 | P=0.145N P=0.051 P=0.111 P=0.004 ** P=0.002 ** P=0.611N |
|POLY 1.5 | P=0.146N P=0.039 * P=0.090 P=0.002 ** P=0.002 ** P=0.626N |
|POLY 6 | P=0.150N P=0.072 P=0.144 P=0.007 ** P=0.003 ** P=0.592N |
|LOGISTIC REGRESSION| P=0.206N P=0.041 * P=0.186 P=0.022 * P=0.007 ** P=0.647N |
|COCH-ARM / FISHERS | P=0.174N P=0.033 * P=0.072 P=0.004 ** P=0.004 ** P=0.650N |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Liver |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 12/15 (80%) 14/15 (93%) 11/15 (73%) 14/15 (93%) 13/15 (87%) 11/15 (73%) |
|POLY-3 RATE (b) | 12/12.95 14/14.05 11/12.72 14/14.86 13/14.10 11/11.68 |
|POLY-3 PERCENT (g) | 92.6% 99.7% 86.5% 94.2% 92.2% 94.1% |
|TERMINAL (d) | 12/12 (100%) 14/14 (100%) 11/12 (92%) 12/12 (100%) 12/13 (92%) 9/9 (100%) |
|FIRST INCIDENCE | 186 (T) 186 (T) 186 (T) 167 182 134 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.069 P=1.000 P=0.500N P=0.265 P=0.752N P=0.194 |
|POLY 3 | P=0.605N P=0.524 P=0.560N P=0.737 P=0.762N P=0.797 |
|POLY 1.5 | P=0.454N P=0.425 P=0.540N P=0.629 P=0.726 P=0.729N |
|POLY 6 | P=0.540 P=0.616 P=0.625N P=0.797 P=0.744N P=0.735 |
|LOGISTIC REGRESSION| P=0.157 P=1.000 P=0.500N P=0.562 P=0.659N P=0.390 |
|COCH-ARM / FISHERS | P=0.277N P=0.299 P=0.500N P=0.299 P=0.500 P=0.500N |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 24
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Liver |
| Myelodysplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 5/15 (33%) |
|POLY-3 RATE (b) | 0/13.43 0/14.34 0/15.00 0/15.00 0/14.39 5/13.53 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 37.0% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/15 (0%) 0/15 (0%) 0/12 (0%) 5/10 (50%) |
|FIRST INCIDENCE | --- --- --- --- --- 185 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) (e) P=0.013 * |
|POLY 3 | P<0.001 ** (e) (e) (e) (e) P=0.016 * |
|POLY 1.5 | P<0.001 ** (e) (e) (e) (e) P=0.016 * |
|POLY 6 | P<0.001 ** (e) (e) (e) (e) P=0.014 * |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) P=0.013 * |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) (e) (e) P=0.021 * |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Liver |
| Myelodysplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) |
|POLY-3 RATE (b) | 0/12.95 0/14.05 0/12.72 0/14.49 0/14.03 0/10.72 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/12 (0%) 0/12 (0%) 0/13 (0%) 0/9 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 25
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Liver |
| Pigmentation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 1/15 (7%) 1/15 (7%) 0/15 (0%) 0/15 (0%) 0/15 (0%) |
|POLY-3 RATE (b) | 0/13.43 1/14.34 1/15.00 0/15.00 0/14.39 0/13.53 |
|POLY-3 PERCENT (g) | 0.0% 7.0% 6.7% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/12 (0%) 1/14 (7%) 1/15 (7%) 0/15 (0%) 0/12 (0%) 0/10 (0%) |
|FIRST INCIDENCE | --- 185 (T) 185 (T) --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.376N P=0.531 P=0.545 (e) (e) (e) |
|POLY 3 | P=0.320N P=0.513 P=0.522 (e) (e) (e) |
|POLY 1.5 | P=0.326N P=0.507 P=0.513 (e) (e) (e) |
|POLY 6 | P=0.314N P=0.521 P=0.533 (e) (e) (e) |
|LOGISTIC REGRESSION| (e) P=0.531 P=0.545 (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.332N P=0.500 P=0.500 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Liver |
| Pigmentation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 11/15 (73%) 11/15 (73%) 9/15 (60%) 13/15 (87%) 5/15 (33%) 2/15 (13%) |
|POLY-3 RATE (b) | 11/12.95 11/14.05 9/12.72 13/14.59 5/14.03 2/11.35 |
|POLY-3 PERCENT (g) | 84.9% 78.3% 70.8% 89.1% 35.6% 17.6% |
|TERMINAL (d) | 11/12 (92%) 11/14 (79%) 9/12 (75%) 12/12 (100%) 5/13 (39%) 1/9 (11%) |
|FIRST INCIDENCE | 186 (T) 186 (T) 186 (T) 180 186 (T) 134 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001N** P=0.356N P=0.296N P=0.249 P=0.011N* P=0.007N** |
|POLY 3 | P<0.001N** P=0.521N P=0.346N P=0.598 P=0.007N** P<0.001N** |
|POLY 1.5 | P<0.001N** P=0.560N P=0.345N P=0.547 P=0.009N** P<0.001N** |
|POLY 6 | P<0.001N** P=0.494N P=0.372N P=0.591 P=0.006N** P<0.001N** |
|LOGISTIC REGRESSION| P<0.001N** P=0.356N P=0.296N P=0.330 P=0.011N* P=0.003N** |
|COCH-ARM / FISHERS | P<0.001N** P=0.659N P=0.350N P=0.326 P=0.033N* P<0.001N** |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 26
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Liver: Hepatocyte |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/15 (7%) 0/15 (0%) 1/15 (7%) 0/15 (0%) 1/15 (7%) 1/15 (7%) |
|POLY-3 RATE (b) | 1/13.43 0/14.34 1/15.00 0/15.00 1/14.39 1/13.53 |
|POLY-3 PERCENT (g) | 7.4% 0.0% 6.7% 0.0% 7.0% 7.4% |
|TERMINAL (d) | 1/12 (8%) 0/14 (0%) 1/15 (7%) 0/15 (0%) 1/12 (8%) 1/10 (10%) |
|FIRST INCIDENCE | 185 (T) --- 185 (T) --- 185 (T) 185 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.360 P=0.469N P=0.714N P=0.455N P=0.765 P=0.724 |
|POLY 3 | P=0.430 P=0.487N P=0.736N P=0.478N P=0.746N P=0.760N |
|POLY 1.5 | P=0.440 P=0.493N P=0.746N P=0.487N P=0.751N P=0.760N |
|POLY 6 | P=0.412 P=0.479N P=0.723N P=0.467N P=0.740N P=0.761 |
|LOGISTIC REGRESSION| P=0.360 (e) P=0.714N (e) P=0.765 P=0.724 |
|COCH-ARM / FISHERS | P=0.450 P=0.500N P=0.759N P=0.500N P=0.759N P=0.759N |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Liver: Hepatocyte |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/15 (13%) 2/15 (13%) 2/15 (13%) 3/15 (20%) 4/15 (27%) 2/15 (13%) |
|POLY-3 RATE (b) | 2/12.95 2/14.05 2/12.72 3/14.49 4/14.03 2/11.06 |
|POLY-3 PERCENT (g) | 15.4% 14.2% 15.7% 20.7% 28.5% 18.1% |
|TERMINAL (d) | 2/12 (17%) 2/14 (14%) 2/12 (17%) 3/12 (25%) 4/13 (31%) 1/9 (11%) |
|FIRST INCIDENCE | 186 (T) 186 (T) 186 (T) 186 (T) 186 (T) 162 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.321 P=0.644N P=0.704 P=0.500 P=0.364 P=0.592 |
|POLY 3 | P=0.358 P=0.670N P=0.694 P=0.553 P=0.365 P=0.642 |
|POLY 1.5 | P=0.401 P=0.676N P=0.695 P=0.547 P=0.359 P=0.664 |
|POLY 6 | P=0.324 P=0.665N P=0.688 P=0.548 P=0.368 P=0.620 |
|LOGISTIC REGRESSION| P=0.355 P=0.644N P=0.704 P=0.500 P=0.364 P=0.641 |
|COCH-ARM / FISHERS | P=0.490 P=0.701N P=0.701N P=0.500 P=0.326 P=0.701N |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 27
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lung |
| Infiltration Cellular |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 1/15 (7%) 3/15 (20%) |
|POLY-3 RATE (b) | 0/13.43 0/14.34 0/15.00 0/15.00 1/14.39 3/13.53 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 7.0% 22.2% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/15 (0%) 0/15 (0%) 1/12 (8%) 3/10 (30%) |
|FIRST INCIDENCE | --- --- --- --- 185 (T) 185 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) P=0.500 P=0.083 |
|POLY 3 | P<0.001 ** (e) (e) (e) P=0.514 P=0.105 |
|POLY 1.5 | P<0.001 ** (e) (e) (e) P=0.508 P=0.106 |
|POLY 6 | P<0.001 ** (e) (e) (e) P=0.519 P=0.102 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) P=0.500 P=0.083 |
|COCH-ARM / FISHERS | P=0.002 ** (e) (e) (e) P=0.500 P=0.112 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lung |
| Infiltration Cellular |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 1/15 (7%) |
|POLY-3 RATE (b) | 0/12.95 0/14.05 0/12.72 0/14.49 0/14.03 1/10.72 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 9.3% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/12 (0%) 0/12 (0%) 0/13 (0%) 1/9 (11%) |
|FIRST INCIDENCE | --- --- --- --- --- 186 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.073 (e) (e) (e) (e) P=0.443 |
|POLY 3 | P=0.090 (e) (e) (e) (e) P=0.462 |
|POLY 1.5 | P=0.095 (e) (e) (e) (e) P=0.477 |
|POLY 6 | P=0.085 (e) (e) (e) (e) P=0.447 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) P=0.443 |
|COCH-ARM / FISHERS | P=0.105 (e) (e) (e) (e) P=0.500 |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 28
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lung |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 1/15 (7%) 2/15 (13%) |
|POLY-3 RATE (b) | 0/13.43 0/14.34 0/15.00 0/15.00 1/14.39 2/13.57 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 7.0% 14.7% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/15 (0%) 0/15 (0%) 1/12 (8%) 1/10 (10%) |
|FIRST INCIDENCE | --- --- --- --- 185 (T) 182 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.006 ** (e) (e) (e) P=0.500 P=0.211 |
|POLY 3 | P=0.012 * (e) (e) (e) P=0.514 P=0.232 |
|POLY 1.5 | P=0.013 * (e) (e) (e) P=0.508 P=0.233 |
|POLY 6 | P=0.011 * (e) (e) (e) P=0.519 P=0.230 |
|LOGISTIC REGRESSION| P=0.009 ** (e) (e) (e) P=0.500 P=0.223 |
|COCH-ARM / FISHERS | P=0.014 * (e) (e) (e) P=0.500 P=0.241 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lung |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 1/15 (7%) 0/15 (0%) 1/15 (7%) |
|POLY-3 RATE (b) | 0/12.95 0/14.05 0/12.72 1/14.49 0/14.03 1/10.72 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 6.9% 0.0% 9.3% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/12 (0%) 1/12 (8%) 0/13 (0%) 1/9 (11%) |
|FIRST INCIDENCE | --- --- --- 186 (T) --- 186 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.172 (e) (e) P=0.500 (e) P=0.443 |
|POLY 3 | P=0.195 (e) (e) P=0.522 (e) P=0.462 |
|POLY 1.5 | P=0.208 (e) (e) P=0.519 (e) P=0.477 |
|POLY 6 | P=0.182 (e) (e) P=0.520 (e) P=0.447 |
|LOGISTIC REGRESSION| (e) (e) (e) P=0.500 (e) P=0.443 |
|COCH-ARM / FISHERS | P=0.230 (e) (e) P=0.500 (e) P=0.500 |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 29
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lung |
| Myelodysplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 3/15 (20%) |
|POLY-3 RATE (b) | 0/13.43 0/14.34 0/15.00 0/15.00 0/14.39 3/13.53 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 22.2% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/15 (0%) 0/15 (0%) 0/12 (0%) 3/10 (30%) |
|FIRST INCIDENCE | --- --- --- --- --- 185 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) (e) P=0.083 |
|POLY 3 | P<0.001 ** (e) (e) (e) (e) P=0.105 |
|POLY 1.5 | P<0.001 ** (e) (e) (e) (e) P=0.106 |
|POLY 6 | P<0.001 ** (e) (e) (e) (e) P=0.102 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) P=0.083 |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) (e) (e) P=0.112 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lung |
| Myelodysplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) |
|POLY-3 RATE (b) | 0/12.95 0/14.05 0/12.72 0/14.49 0/14.03 0/10.72 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/12 (0%) 0/12 (0%) 0/13 (0%) 0/9 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 30
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lymph Node |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/14 (0%) 0/15 (0%) 0/14 (0%) 0/13 (0%) 0/15 (0%) 0/14 (0%) |
|POLY-3 RATE (b) | 0/13.07 0/14.34 0/14.00 0/13.00 0/14.39 0/12.53 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/14 (0%) 0/13 (0%) 0/12 (0%) 0/9 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lymph Node |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/14 (0%) 0/13 (0%) 0/12 (0%) 0/15 (0%) 2/14 (14%) |
|POLY-3 RATE (b) | 0/12.95 0/13.05 0/10.72 0/11.49 0/14.03 2/10.57 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 18.9% |
|TERMINAL (d) | 0/12 (0%) 0/13 (0%) 0/10 (0%) 0/9 (0%) 0/13 (0%) 2/9 (22%) |
|FIRST INCIDENCE | --- --- --- --- --- 186 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.006 ** (e) (e) (e) (e) P=0.173 |
|POLY 3 | P=0.009 ** (e) (e) (e) (e) P=0.184 |
|POLY 1.5 | P=0.009 ** (e) (e) (e) (e) P=0.196 |
|POLY 6 | P=0.009 ** (e) (e) (e) (e) P=0.170 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) P=0.173 |
|COCH-ARM / FISHERS | P=0.012 * (e) (e) (e) (e) P=0.224 |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 31
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 3/15 (20%) 0/15 (0%) |
|POLY-3 RATE (b) | 0/13.43 0/14.34 0/15.00 0/15.00 3/14.39 0/13.53 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 20.9% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/15 (0%) 0/15 (0%) 3/12 (25%) 0/10 (0%) |
|FIRST INCIDENCE | --- --- --- --- 185 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.237 (e) (e) (e) P=0.113 (e) |
|POLY 3 | P=0.263 (e) (e) (e) P=0.118 (e) |
|POLY 1.5 | P=0.282 (e) (e) (e) P=0.113 (e) |
|POLY 6 | P=0.234 (e) (e) (e) P=0.122 (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) P=0.113 (e) |
|COCH-ARM / FISHERS | P=0.315 (e) (e) (e) P=0.112 (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 1/15 (7%) 8/13 (62%) |
|POLY-3 RATE (b) | 0/12.95 0/14.05 0/12.72 0/14.49 1/14.03 8/10.03 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 7.1% 79.7% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/12 (0%) 0/12 (0%) 1/13 (8%) 8/9 (89%) |
|FIRST INCIDENCE | --- --- --- --- 186 (T) 186 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) P=0.516 P<0.001 ** |
|POLY 3 | P<0.001 ** (e) (e) (e) P=0.516 P<0.001 ** |
|POLY 1.5 | P<0.001 ** (e) (e) (e) P=0.513 P<0.001 ** |
|POLY 6 | P<0.001 ** (e) (e) (e) P=0.517 P<0.001 ** |
|LOGISTIC REGRESSION| (e) (e) (e) (e) P=0.516 P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) (e) P=0.500 P<0.001 ** |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 32
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 2/15 (13%) 1/15 (7%) 2/15 (13%) 1/15 (7%) |
|POLY-3 RATE (b) | 0/13.43 0/14.34 2/15.00 1/15.00 2/14.41 1/13.75 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 13.3% 6.7% 13.9% 7.3% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 2/15 (13%) 1/15 (7%) 1/12 (8%) 0/10 (0%) |
|FIRST INCIDENCE | --- --- 185 (T) 185 (T) 184 170 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.259 (e) P=0.286 P=0.545 P=0.249 P=0.500 |
|POLY 3 | P=0.344 (e) P=0.257 P=0.522 P=0.247 P=0.505 |
|POLY 1.5 | P=0.349 (e) P=0.246 P=0.513 P=0.241 P=0.503 |
|POLY 6 | P=0.333 (e) P=0.271 P=0.533 P=0.253 P=0.505 |
|LOGISTIC REGRESSION| P=0.340 (e) P=0.286 P=0.545 P=0.251 P=0.488 |
|COCH-ARM / FISHERS | P=0.350 (e) P=0.241 P=0.500 P=0.241 P=0.500 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/15 (20%) 0/15 (0%) 1/15 (7%) 5/15 (33%) 3/15 (20%) 1/13 (8%) |
|POLY-3 RATE (b) | 3/13.09 0/14.05 1/12.72 5/15.00 3/14.03 1/10.03 |
|POLY-3 PERCENT (g) | 22.9% 0.0% 7.9% 33.3% 21.4% 10.0% |
|TERMINAL (d) | 2/12 (17%) 0/14 (0%) 1/12 (8%) 2/12 (17%) 3/13 (23%) 1/9 (11%) |
|FIRST INCIDENCE | 177 --- 186 (T) 167 186 (T) 186 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.551 P=0.099N P=0.310N P=0.382 P=0.632N P=0.419N |
|POLY 3 | P=0.529 P=0.092N P=0.307N P=0.427 P=0.638N P=0.400N |
|POLY 1.5 | P=0.562 P=0.095N P=0.303N P=0.410 P=0.642N P=0.383N |
|POLY 6 | P=0.499 P=0.092N P=0.317N P=0.431 P=0.640N P=0.419N |
|LOGISTIC REGRESSION| P=0.591 P=0.099N P=0.303N P=0.377 P=0.639N P=0.400N |
|COCH-ARM / FISHERS | P=0.546N P=0.112N P=0.299N P=0.341 P=0.674N P=0.356N |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 33
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Infiltration Cellular |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 5/15 (33%) 6/15 (40%) |
|POLY-3 RATE (b) | 0/13.43 0/14.34 0/15.00 0/15.00 5/14.39 6/13.53 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 34.8% 44.4% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/15 (0%) 0/15 (0%) 5/12 (42%) 6/10 (60%) |
|FIRST INCIDENCE | --- --- --- --- 185 (T) 185 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) P=0.025 * P=0.005 ** |
|POLY 3 | P<0.001 ** (e) (e) (e) P=0.021 * P=0.005 ** |
|POLY 1.5 | P<0.001 ** (e) (e) (e) P=0.019 * P=0.005 ** |
|POLY 6 | P<0.001 ** (e) (e) (e) P=0.022 * P=0.004 ** |
|LOGISTIC REGRESSION| (e) (e) (e) (e) P=0.025 * P=0.005 ** |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) (e) P=0.021 * P=0.008 ** |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Infiltration Cellular |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 1/15 (7%) 2/15 (13%) 2/13 (15%) |
|POLY-3 RATE (b) | 0/12.95 0/14.05 0/12.72 1/14.49 2/14.03 2/10.03 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 6.9% 14.3% 19.9% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/12 (0%) 1/12 (8%) 2/13 (15%) 2/9 (22%) |
|FIRST INCIDENCE | --- --- --- 186 (T) 186 (T) 186 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.012 * (e) (e) P=0.500 P=0.253 P=0.173 |
|POLY 3 | P=0.013 * (e) (e) P=0.522 P=0.250 P=0.172 |
|POLY 1.5 | P=0.015 * (e) (e) P=0.519 P=0.246 P=0.180 |
|POLY 6 | P=0.011 * (e) (e) P=0.520 P=0.251 P=0.165 |
|LOGISTIC REGRESSION| (e) (e) (e) P=0.500 P=0.253 P=0.173 |
|COCH-ARM / FISHERS | P=0.021 * (e) (e) P=0.500 P=0.241 P=0.206 |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 34
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Infiltration Cellular Plasma Cell |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 1/15 (7%) 6/15 (40%) |
|POLY-3 RATE (b) | 0/13.43 0/14.34 0/15.00 0/15.00 1/14.39 6/13.53 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 7.0% 44.4% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/15 (0%) 0/15 (0%) 1/12 (8%) 6/10 (60%) |
|FIRST INCIDENCE | --- --- --- --- 185 (T) 185 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) P=0.500 P=0.005 ** |
|POLY 3 | P<0.001 ** (e) (e) (e) P=0.514 P=0.005 ** |
|POLY 1.5 | P<0.001 ** (e) (e) (e) P=0.508 P=0.005 ** |
|POLY 6 | P<0.001 ** (e) (e) (e) P=0.519 P=0.004 ** |
|LOGISTIC REGRESSION| (e) (e) (e) (e) P=0.500 P=0.005 ** |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) (e) P=0.500 P=0.008 ** |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Infiltration Cellular Plasma Cell |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 1/15 (7%) 1/13 (8%) |
|POLY-3 RATE (b) | 0/12.95 0/14.05 0/12.72 0/14.49 1/14.03 1/10.03 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 7.1% 10.0% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/12 (0%) 0/12 (0%) 1/13 (8%) 1/9 (11%) |
|FIRST INCIDENCE | --- --- --- --- 186 (T) 186 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.065 (e) (e) (e) P=0.516 P=0.443 |
|POLY 3 | P=0.065 (e) (e) (e) P=0.516 P=0.449 |
|POLY 1.5 | P=0.070 (e) (e) (e) P=0.513 P=0.456 |
|POLY 6 | P=0.060 (e) (e) (e) P=0.517 P=0.441 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) P=0.516 P=0.443 |
|COCH-ARM / FISHERS | P=0.085 (e) (e) (e) P=0.500 P=0.464 |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 35
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Myelodysplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 2/15 (13%) |
|POLY-3 RATE (b) | 0/13.43 0/14.34 0/15.00 0/15.00 0/14.39 2/13.53 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 14.8% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/15 (0%) 0/15 (0%) 0/12 (0%) 2/10 (20%) |
|FIRST INCIDENCE | --- --- --- --- --- 185 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.004 ** (e) (e) (e) (e) P=0.195 |
|POLY 3 | P=0.008 ** (e) (e) (e) (e) P=0.232 |
|POLY 1.5 | P=0.009 ** (e) (e) (e) (e) P=0.232 |
|POLY 6 | P=0.008 ** (e) (e) (e) (e) P=0.228 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) P=0.195 |
|COCH-ARM / FISHERS | P=0.011 * (e) (e) (e) (e) P=0.241 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Myelodysplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/13 (0%) |
|POLY-3 RATE (b) | 0/12.95 0/14.05 0/12.72 0/14.49 0/14.03 0/10.03 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/12 (0%) 0/12 (0%) 0/13 (0%) 0/9 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 36
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Necrosis Lymphoid |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 2/15 (13%) 0/15 (0%) |
|POLY-3 RATE (b) | 0/13.43 0/14.34 0/15.00 0/15.00 2/14.72 0/13.53 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 13.6% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/15 (0%) 0/15 (0%) 0/12 (0%) 0/10 (0%) |
|FIRST INCIDENCE | --- --- --- --- 163 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.382 (e) (e) (e) P=0.273 (e) |
|POLY 3 | P=0.366 (e) (e) (e) P=0.253 (e) |
|POLY 1.5 | P=0.388 (e) (e) (e) P=0.244 (e) |
|POLY 6 | P=0.332 (e) (e) (e) P=0.263 (e) |
|LOGISTIC REGRESSION| P=0.425 (e) (e) (e) P=0.171 (e) |
|COCH-ARM / FISHERS | P=0.414 (e) (e) (e) P=0.241 (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Necrosis Lymphoid |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 1/15 (7%) 1/15 (7%) 0/15 (0%) 0/15 (0%) 0/13 (0%) |
|POLY-3 RATE (b) | 0/12.95 1/15.00 1/13.72 0/14.49 0/14.03 0/10.03 |
|POLY-3 PERCENT (g) | 0.0% 6.7% 7.3% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/12 (0%) 0/12 (0%) 0/13 (0%) 0/9 (0%) |
|FIRST INCIDENCE | --- 67 5 --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.334N P=0.514 P=0.500 (e) (e) (e) |
|POLY 3 | P=0.323N P=0.529 P=0.511 (e) (e) (e) |
|POLY 1.5 | P=0.330N P=0.523 P=0.512 (e) (e) (e) |
|POLY 6 | P=0.318N P=0.532 P=0.509 (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.215N P=0.327 (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.351N P=0.500 P=0.500 (e) (e) (e) |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 37
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lymph Node, Mesenteric |
| Infiltration Cellular |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/12 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 4/15 (27%) 2/14 (14%) |
|POLY-3 RATE (b) | 0/11.59 0/14.34 0/15.00 0/15.00 4/14.39 2/12.57 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 27.8% 15.9% |
|TERMINAL (d) | 0/11 (0%) 0/14 (0%) 0/15 (0%) 0/15 (0%) 4/12 (33%) 2/10 (20%) |
|FIRST INCIDENCE | --- --- --- --- 185 (T) 185 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.004 ** (e) (e) (e) P=0.064 P=0.213 |
|POLY 3 | P=0.006 ** (e) (e) (e) P=0.072 P=0.248 |
|POLY 1.5 | P=0.007 ** (e) (e) (e) P=0.073 P=0.256 |
|POLY 6 | P=0.004 ** (e) (e) (e) P=0.069 P=0.236 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) P=0.064 P=0.213 |
|COCH-ARM / FISHERS | P=0.012 * (e) (e) (e) P=0.078 P=0.280 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lymph Node, Mesenteric |
| Infiltration Cellular |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/14 (0%) 0/15 (0%) 0/15 (0%) 0/14 (0%) 4/15 (27%) 0/15 (0%) |
|POLY-3 RATE (b) | 0/12.09 0/14.05 0/12.72 0/13.63 4/14.03 0/10.72 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 28.5% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/12 (0%) 0/12 (0%) 4/13 (31%) 0/9 (0%) |
|FIRST INCIDENCE | --- --- --- --- 186 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.170 (e) (e) (e) P=0.064 (e) |
|POLY 3 | P=0.089 (e) (e) (e) P=0.063 (e) |
|POLY 1.5 | P=0.131 (e) (e) (e) P=0.062 (e) |
|POLY 6 | P=0.058 (e) (e) (e) P=0.063 (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) P=0.064 (e) |
|COCH-ARM / FISHERS | P=0.257 (e) (e) (e) P=0.057 (e) |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 38
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lymph Node, Mesenteric |
| Myelodysplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/12 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 3/14 (21%) |
|POLY-3 RATE (b) | 0/11.59 0/14.34 0/15.00 0/15.00 0/14.39 3/12.57 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 23.9% |
|TERMINAL (d) | 0/11 (0%) 0/14 (0%) 0/15 (0%) 0/15 (0%) 0/12 (0%) 3/10 (30%) |
|FIRST INCIDENCE | --- --- --- --- --- 185 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) (e) P=0.096 |
|POLY 3 | P<0.001 ** (e) (e) (e) (e) P=0.116 |
|POLY 1.5 | P<0.001 ** (e) (e) (e) (e) P=0.124 |
|POLY 6 | P<0.001 ** (e) (e) (e) (e) P=0.106 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) P=0.096 |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) (e) (e) P=0.140 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lymph Node, Mesenteric |
| Myelodysplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/14 (0%) 0/15 (0%) 0/15 (0%) 0/14 (0%) 0/15 (0%) 0/15 (0%) |
|POLY-3 RATE (b) | 0/12.09 0/14.05 0/12.72 0/13.63 0/14.03 0/10.72 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/12 (0%) 0/12 (0%) 0/13 (0%) 0/9 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 39
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lymph Node: Mediastinal |
| Infiltration Cellular |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/14 (0%) 0/15 (0%) 0/14 (0%) 0/13 (0%) 4/15 (27%) 2/14 (14%) |
|POLY-3 RATE (b) | 0/13.07 0/14.34 0/14.00 0/13.00 4/14.39 2/12.53 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 27.8% 16.0% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/14 (0%) 0/13 (0%) 4/12 (33%) 2/9 (22%) |
|FIRST INCIDENCE | --- --- --- --- 185 (T) 185 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.003 ** (e) (e) (e) P=0.054 P=0.173 |
|POLY 3 | P=0.006 ** (e) (e) (e) P=0.056 P=0.220 |
|POLY 1.5 | P=0.007 ** (e) (e) (e) P=0.055 P=0.225 |
|POLY 6 | P=0.004 ** (e) (e) (e) P=0.056 P=0.211 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) P=0.054 P=0.173 |
|COCH-ARM / FISHERS | P=0.013 * (e) (e) (e) P=0.057 P=0.241 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Lymph Node: Mediastinal |
| Infiltration Cellular |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/14 (0%) 0/13 (0%) 0/12 (0%) 3/15 (20%) 1/14 (7%) |
|POLY-3 RATE (b) | 0/12.95 0/13.05 0/10.72 0/11.49 3/14.03 1/10.57 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 21.4% 9.5% |
|TERMINAL (d) | 0/12 (0%) 0/13 (0%) 0/10 (0%) 0/9 (0%) 3/13 (23%) 1/9 (11%) |
|FIRST INCIDENCE | --- --- --- --- 186 (T) 186 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.050 (e) (e) (e) P=0.128 P=0.443 |
|POLY 3 | P=0.039 * (e) (e) (e) P=0.120 P=0.459 |
|POLY 1.5 | P=0.049 * (e) (e) (e) P=0.117 P=0.470 |
|POLY 6 | P=0.030 * (e) (e) (e) P=0.121 P=0.446 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) P=0.128 P=0.443 |
|COCH-ARM / FISHERS | P=0.080 (e) (e) (e) P=0.112 P=0.483 |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 40
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Ovary |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | |
|POLY-3 RATE (b) | |
|POLY-3 PERCENT (g) | |
|TERMINAL (d) | |
|FIRST INCIDENCE | |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | |
|POLY 3 | |
|POLY 1.5 | |
|POLY 6 | |
|LOGISTIC REGRESSION| |
|COCH-ARM / FISHERS | |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Ovary |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/15 (7%) 0/15 (0%) 0/15 (0%) 1/15 (7%) 2/15 (13%) 0/15 (0%) |
|POLY-3 RATE (b) | 1/13.92 0/14.05 0/12.72 1/14.77 2/14.03 0/10.72 |
|POLY-3 PERCENT (g) | 7.2% 0.0% 0.0% 6.8% 14.3% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/12 (0%) 0/12 (0%) 2/13 (15%) 0/9 (0%) |
|FIRST INCIDENCE | 63 --- --- 167 186 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.614 P=0.500N P=0.514N P=0.745N P=0.519 P=0.514N |
|POLY 3 | P=0.517 P=0.498N P=0.518N P=0.747N P=0.503 P=0.551N |
|POLY 1.5 | P=0.571 P=0.499N P=0.514N P=0.749N P=0.503 P=0.535N |
|POLY 6 | P=0.464 P=0.496N P=0.522N P=0.748N P=0.504 P=0.567N |
|LOGISTIC REGRESSION| P=0.572N (e) P=0.389N P=0.462 P=0.400 P=0.383N |
|COCH-ARM / FISHERS | P=0.622N P=0.500N P=0.500N P=0.759N P=0.500 P=0.500N |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 41
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/15 (7%) 0/14 (0%) 0/15 (0%) 0/15 (0%) 3/15 (20%) 0/15 (0%) |
|POLY-3 RATE (b) | 1/13.43 0/13.34 0/15.00 0/15.00 3/14.39 0/13.53 |
|POLY-3 PERCENT (g) | 7.4% 0.0% 0.0% 0.0% 20.9% 0.0% |
|TERMINAL (d) | 1/12 (8%) 0/13 (0%) 0/15 (0%) 0/15 (0%) 3/12 (25%) 0/10 (0%) |
|FIRST INCIDENCE | 185 (T) --- --- --- 185 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.446 P=0.484N P=0.455N P=0.455N P=0.296 P=0.536N |
|POLY 3 | P=0.482 P=0.501N P=0.478N P=0.478N P=0.323 P=0.499N |
|POLY 1.5 | P=0.506 P=0.507N P=0.487N P=0.487N P=0.313 P=0.499N |
|POLY 6 | P=0.445 P=0.494N P=0.467N P=0.467N P=0.332 P=0.501N |
|LOGISTIC REGRESSION| P=0.446 (e) (e) (e) P=0.296 (e) |
|COCH-ARM / FISHERS | P=0.531 P=0.517N P=0.500N P=0.500N P=0.299 P=0.500N |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/15 (20%) 0/15 (0%) 2/14 (14%) 2/15 (13%) 4/15 (27%) 2/15 (13%) |
|POLY-3 RATE (b) | 3/12.95 0/14.05 2/12.51 2/14.49 4/14.03 2/10.72 |
|POLY-3 PERCENT (g) | 23.2% 0.0% 16.0% 13.8% 28.5% 18.7% |
|TERMINAL (d) | 3/12 (25%) 0/14 (0%) 2/12 (17%) 2/12 (17%) 4/13 (31%) 2/9 (22%) |
|FIRST INCIDENCE | 186 (T) --- 186 (T) 186 (T) 186 (T) 186 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.241 P=0.089N P=0.500N P=0.500N P=0.549 P=0.641N |
|POLY 3 | P=0.251 P=0.090N P=0.517N P=0.446N P=0.547 P=0.591N |
|POLY 1.5 | P=0.299 P=0.094N P=0.523N P=0.453N P=0.539 P=0.556N |
|POLY 6 | P=0.210 P=0.088N P=0.519N P=0.452N P=0.551 P=0.628N |
|LOGISTIC REGRESSION| P=0.241 (e) P=0.500N P=0.500N P=0.549 P=0.641N |
|COCH-ARM / FISHERS | P=0.406 P=0.112N P=0.535N P=0.500N P=0.500 P=0.500N |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 42
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Skin: Epidermis, Skin, Site of Application |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 3/15 (20%) 8/15 (53%) 10/15 (67%) 14/15 (93%) |
|POLY-3 RATE (b) | 0/13.43 0/14.34 3/15.00 8/15.00 10/14.67 14/15.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 20.0% 53.3% 68.2% 93.3% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 3/15 (20%) 8/15 (53%) 9/12 (75%) 9/10 (90%) |
|FIRST INCIDENCE | --- --- 185 (T) 185 (T) 166 138 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) P=0.157 P=0.005 ** P<0.001 ** P<0.001 ** |
|POLY 3 | P<0.001 ** (e) P=0.127 P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** (e) P=0.118 P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 6 | P<0.001 ** (e) P=0.139 P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** (e) P=0.157 P=0.005 ** P<0.001 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** (e) P=0.112 P<0.001 ** P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Skin: Epidermis, Skin, Site of Application |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 5/15 (33%) 14/15 (93%) 14/15 (93%) 14/15 (93%) |
|POLY-3 RATE (b) | 0/12.95 0/14.05 5/13.51 14/15.00 14/14.10 14/14.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 37.0% 93.3% 99.3% 100.0% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 4/12 (33%) 11/12 (92%) 13/13 (100%) 9/9 (100%) |
|FIRST INCIDENCE | --- --- 109 167 182 98 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) P=0.031 * P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 3 | P<0.001 ** (e) P=0.018 * P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** (e) P=0.017 * P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 6 | P<0.001 ** (e) P=0.018 * P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** (e) P=0.025 * P<0.001 ** P<0.001 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** (e) P=0.021 * P<0.001 ** P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 43
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Skin: Skin, Site of Application |
| Hyperkeratosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/15 (7%) 0/15 (0%) 2/15 (13%) 6/15 (40%) 10/15 (67%) 13/15 (87%) |
|POLY-3 RATE (b) | 1/14.07 0/14.34 2/15.00 6/15.00 10/14.68 13/15.00 |
|POLY-3 PERCENT (g) | 7.1% 0.0% 13.3% 40.0% 68.1% 86.7% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 2/15 (13%) 6/15 (40%) 8/12 (67%) 8/10 (80%) |
|FIRST INCIDENCE | 132 --- 185 (T) 185 (T) 166 138 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** P=0.514N P=0.552 P=0.083 P=0.004 ** P<0.001 ** |
|POLY 3 | P<0.001 ** P=0.496N P=0.523 P=0.043 * P<0.001 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** P=0.498N P=0.513 P=0.039 * P<0.001 ** P<0.001 ** |
|POLY 6 | P<0.001 ** P=0.492N P=0.535 P=0.049 * P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** P=0.484N P=0.218 P=0.015 * P<0.001 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** P=0.500N P=0.500 P=0.040 * P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Skin: Skin, Site of Application |
| Hyperkeratosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/15 (7%) 0/15 (0%) 4/15 (27%) 14/15 (93%) 11/15 (73%) 13/15 (87%) |
|POLY-3 RATE (b) | 1/13.09 0/14.05 4/13.51 14/15.00 11/14.94 13/14.00 |
|POLY-3 PERCENT (g) | 7.6% 0.0% 29.6% 93.3% 73.6% 92.8% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 3/12 (25%) 11/12 (92%) 10/13 (77%) 8/9 (89%) |
|FIRST INCIDENCE | 177 --- 109 167 85 98 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** P=0.485N P=0.179 P<0.001 ** P=0.002 ** P<0.001 ** |
|POLY 3 | P<0.001 ** P=0.486N P=0.169 P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** P=0.489N P=0.167 P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 6 | P<0.001 ** P=0.485N P=0.165 P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** P=0.496N P=0.163 P<0.001 ** P<0.001 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** P=0.500N P=0.165 P<0.001 ** P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 44
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Skin: Skin, Site of Application |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 2/15 (13%) 5/15 (33%) 12/15 (80%) |
|POLY-3 RATE (b) | 0/13.43 0/14.34 0/15.00 2/15.00 5/14.39 12/14.19 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 13.3% 34.8% 84.6% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/15 (0%) 2/15 (13%) 5/12 (42%) 9/10 (90%) |
|FIRST INCIDENCE | --- --- --- 185 (T) 185 (T) 160 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) P=0.286 P=0.025 * P<0.001 ** |
|POLY 3 | P<0.001 ** (e) (e) P=0.257 P=0.021 * P<0.001 ** |
|POLY 1.5 | P<0.001 ** (e) (e) P=0.246 P=0.019 * P<0.001 ** |
|POLY 6 | P<0.001 ** (e) (e) P=0.271 P=0.022 * P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** (e) (e) P=0.286 P=0.025 * P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) P=0.241 P=0.021 * P<0.001 ** |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Skin: Skin, Site of Application |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 1/15 (7%) 9/15 (60%) 10/15 (67%) 15/15 (100%) |
|POLY-3 RATE (b) | 0/12.95 0/14.05 1/12.72 9/14.77 10/14.03 15/15.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 7.9% 60.9% 71.3% 100.0% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 1/12 (8%) 8/12 (67%) 10/13 (77%) 9/9 (100%) |
|FIRST INCIDENCE | --- --- 186 (T) 167 186 (T) 27 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) P=0.500 P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 3 | P<0.001 ** (e) P=0.496 P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** (e) P=0.497 P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 6 | P<0.001 ** (e) P=0.493 P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** (e) P=0.500 P<0.001 ** P<0.001 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** (e) P=0.500 P<0.001 ** P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 45
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Spleen |
| Depletion Cellular |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 2/15 (13%) 2/15 (13%) |
|POLY-3 RATE (b) | 0/13.43 0/14.34 0/15.00 0/15.00 2/14.98 2/14.01 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 13.4% 14.3% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/15 (0%) 0/15 (0%) 0/12 (0%) 0/10 (0%) |
|FIRST INCIDENCE | --- --- --- --- 163 167 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.013 * (e) (e) (e) P=0.282 P=0.249 |
|POLY 3 | P=0.012 * (e) (e) (e) P=0.257 P=0.240 |
|POLY 1.5 | P=0.013 * (e) (e) (e) P=0.246 P=0.237 |
|POLY 6 | P=0.011 * (e) (e) (e) P=0.271 P=0.244 |
|LOGISTIC REGRESSION| P=0.019 * (e) (e) (e) P=0.085 P=0.211 |
|COCH-ARM / FISHERS | P=0.015 * (e) (e) (e) P=0.241 P=0.241 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Spleen |
| Depletion Cellular |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/15 (13%) 1/15 (7%) 2/15 (13%) 1/15 (7%) 2/15 (13%) 3/15 (20%) |
|POLY-3 RATE (b) | 2/14.05 1/15.00 2/14.20 1/14.63 2/15.00 3/12.81 |
|POLY-3 PERCENT (g) | 14.2% 6.7% 14.1% 6.8% 13.3% 23.4% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/12 (0%) 0/12 (0%) 0/13 (0%) 0/9 (0%) |
|FIRST INCIDENCE | 63 67 5 177 85 113 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.197 P=0.484N P=0.678 P=0.483N P=0.658N P=0.439 |
|POLY 3 | P=0.203 P=0.477N P=0.695N P=0.486N P=0.674N P=0.456 |
|POLY 1.5 | P=0.210 P=0.481N P=0.693N P=0.486N P=0.679N P=0.466 |
|POLY 6 | P=0.197 P=0.476N P=0.698N P=0.491N P=0.673N P=0.444 |
|LOGISTIC REGRESSION| P=0.434 P=0.716N P=0.744N P=0.770N P=0.554 P=0.617 |
|COCH-ARM / FISHERS | P=0.238 P=0.500N P=0.701N P=0.500N P=0.701N P=0.500 |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 46
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Spleen |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/15 (7%) 2/15 (13%) 1/15 (7%) 2/15 (13%) 9/15 (60%) 8/15 (53%) |
|POLY-3 RATE (b) | 1/13.43 2/15.00 1/15.00 2/15.00 9/14.39 8/13.57 |
|POLY-3 PERCENT (g) | 7.4% 13.3% 6.7% 13.3% 62.5% 58.9% |
|TERMINAL (d) | 1/12 (8%) 1/14 (7%) 1/15 (7%) 2/15 (13%) 9/12 (75%) 7/10 (70%) |
|FIRST INCIDENCE | 185 (T) 129 185 (T) 185 (T) 185 (T) 182 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** P=0.536 P=0.714N P=0.580 P=0.002 ** P=0.003 ** |
|POLY 3 | P<0.001 ** P=0.539 P=0.736N P=0.539 P<0.001 ** P=0.003 ** |
|POLY 1.5 | P<0.001 ** P=0.523 P=0.746N P=0.523 P<0.001 ** P=0.003 ** |
|POLY 6 | P<0.001 ** P=0.558 P=0.723N P=0.558 P<0.001 ** P=0.002 ** |
|LOGISTIC REGRESSION| P<0.001 ** P=0.430 P=0.714N P=0.580 P=0.002 ** P=0.003 ** |
|COCH-ARM / FISHERS | P<0.001 ** P=0.500 P=0.759N P=0.500 P=0.003 ** P=0.007 ** |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Spleen |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 2/15 (13%) 11/15 (73%) 11/15 (73%) |
|POLY-3 RATE (b) | 0/12.95 0/14.05 0/12.72 2/14.49 11/14.03 11/11.91 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 13.8% 78.4% 92.3% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/12 (0%) 2/12 (17%) 11/13 (85%) 9/9 (100%) |
|FIRST INCIDENCE | --- --- --- 186 (T) 186 (T) 98 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) P=0.235 P<0.001 ** P<0.001 ** |
|POLY 3 | P<0.001 ** (e) (e) P=0.258 P<0.001 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** (e) (e) P=0.254 P<0.001 ** P<0.001 ** |
|POLY 6 | P<0.001 ** (e) (e) P=0.254 P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** (e) (e) P=0.235 P<0.001 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) P=0.241 P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 47
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Spleen |
| Infiltration Cellular |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 1/15 (7%) 4/15 (27%) |
|POLY-3 RATE (b) | 0/13.43 0/14.34 0/15.00 0/15.00 1/14.39 4/13.53 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 7.0% 29.6% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/15 (0%) 0/15 (0%) 1/12 (8%) 4/10 (40%) |
|FIRST INCIDENCE | --- --- --- --- 185 (T) 185 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) P=0.500 P=0.034 * |
|POLY 3 | P<0.001 ** (e) (e) (e) P=0.514 P=0.043 * |
|POLY 1.5 | P<0.001 ** (e) (e) (e) P=0.508 P=0.045 * |
|POLY 6 | P<0.001 ** (e) (e) (e) P=0.519 P=0.041 * |
|LOGISTIC REGRESSION| (e) (e) (e) (e) P=0.500 P=0.034 * |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) (e) P=0.500 P=0.050 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Spleen |
| Infiltration Cellular |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 1/15 (7%) 1/15 (7%) |
|POLY-3 RATE (b) | 0/12.95 0/14.05 0/12.72 0/14.49 1/14.03 1/10.72 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 7.1% 9.3% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/12 (0%) 0/12 (0%) 1/13 (8%) 1/9 (11%) |
|FIRST INCIDENCE | --- --- --- --- 186 (T) 186 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.065 (e) (e) (e) P=0.516 P=0.443 |
|POLY 3 | P=0.068 (e) (e) (e) P=0.516 P=0.462 |
|POLY 1.5 | P=0.080 (e) (e) (e) P=0.513 P=0.477 |
|POLY 6 | P=0.059 (e) (e) (e) P=0.517 P=0.447 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) P=0.516 P=0.443 |
|COCH-ARM / FISHERS | P=0.104 (e) (e) (e) P=0.500 P=0.500 |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 48
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Spleen |
| Myelodysplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 4/15 (27%) |
|POLY-3 RATE (b) | 0/13.43 0/14.34 0/15.00 0/15.00 0/14.39 4/13.53 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 29.6% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/15 (0%) 0/15 (0%) 0/12 (0%) 4/10 (40%) |
|FIRST INCIDENCE | --- --- --- --- --- 185 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) (e) P=0.034 * |
|POLY 3 | P<0.001 ** (e) (e) (e) (e) P=0.043 * |
|POLY 1.5 | P<0.001 ** (e) (e) (e) (e) P=0.045 * |
|POLY 6 | P<0.001 ** (e) (e) (e) (e) P=0.041 * |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) P=0.034 * |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) (e) (e) P=0.050 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Spleen |
| Myelodysplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) |
|POLY-3 RATE (b) | 0/12.95 0/14.05 0/12.72 0/14.49 0/14.03 0/10.72 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/12 (0%) 0/12 (0%) 0/13 (0%) 0/9 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 49
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Spleen |
| Necrosis Lymphoid |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 2/15 (13%) 1/15 (7%) |
|POLY-3 RATE (b) | 0/13.43 0/14.34 0/15.00 0/15.00 2/14.68 1/13.88 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 13.6% 7.2% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/15 (0%) 0/15 (0%) 0/12 (0%) 0/10 (0%) |
|FIRST INCIDENCE | --- --- --- --- 166 160 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.078 (e) (e) (e) P=0.266 P=0.531 |
|POLY 3 | P=0.080 (e) (e) (e) P=0.252 P=0.507 |
|POLY 1.5 | P=0.084 (e) (e) (e) P=0.243 P=0.504 |
|POLY 6 | P=0.074 (e) (e) (e) P=0.262 P=0.508 |
|LOGISTIC REGRESSION| P=0.106 (e) (e) (e) P=0.186 P=0.458 |
|COCH-ARM / FISHERS | P=0.091 (e) (e) (e) P=0.241 P=0.500 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Spleen |
| Necrosis Lymphoid |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 1/15 (7%) 1/15 (7%) 0/15 (0%) 1/15 (7%) 0/15 (0%) |
|POLY-3 RATE (b) | 0/12.95 1/15.00 1/13.72 0/14.49 1/14.10 0/10.72 |
|POLY-3 PERCENT (g) | 0.0% 6.7% 7.3% 0.0% 7.1% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/12 (0%) 0/12 (0%) 0/13 (0%) 0/9 (0%) |
|FIRST INCIDENCE | --- 67 5 --- 182 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.501N P=0.514 P=0.500 (e) P=0.531 (e) |
|POLY 3 | P=0.512N P=0.529 P=0.511 (e) P=0.517 (e) |
|POLY 1.5 | P=0.501N P=0.523 P=0.512 (e) P=0.514 (e) |
|POLY 6 | P=0.521N P=0.532 P=0.509 (e) P=0.519 (e) |
|LOGISTIC REGRESSION| P=0.375N P=0.327 (e) (e) P=0.512 (e) |
|COCH-ARM / FISHERS | P=0.479N P=0.500 P=0.500 (e) P=0.500 (e) |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 50
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Hyperkeratosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/15 (13%) 0/15 (0%) 1/15 (7%) 0/15 (0%) 3/15 (20%) 4/15 (27%) |
|POLY-3 RATE (b) | 2/14.48 0/14.34 1/15.00 0/15.00 3/15.00 4/14.74 |
|POLY-3 PERCENT (g) | 13.8% 0.0% 6.7% 0.0% 20.0% 27.2% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 1/15 (7%) 0/15 (0%) 0/12 (0%) 0/10 (0%) |
|FIRST INCIDENCE | 132 --- 185 (T) --- 163 138 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.016 * P=0.239N P=0.458N P=0.224N P=0.553 P=0.357 |
|POLY 3 | P=0.017 * P=0.233N P=0.488N P=0.223N P=0.517 P=0.335 |
|POLY 1.5 | P=0.017 * P=0.233N P=0.493N P=0.227N P=0.510 P=0.332 |
|POLY 6 | P=0.016 * P=0.233N P=0.481N P=0.219N P=0.525 P=0.337 |
|LOGISTIC REGRESSION| P=0.018 * P=0.268N P=0.585 P=0.978N P=0.142 P=0.173 |
|COCH-ARM / FISHERS | P=0.018 * P=0.241N P=0.500N P=0.241N P=0.500 P=0.326 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Hyperkeratosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/15 (7%) 0/15 (0%) 3/15 (20%) 3/15 (20%) 4/15 (27%) 4/15 (27%) |
|POLY-3 RATE (b) | 1/13.92 0/14.05 3/15.00 3/15.00 4/15.00 4/13.04 |
|POLY-3 PERCENT (g) | 7.2% 0.0% 20.0% 20.0% 26.7% 30.7% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/12 (0%) 0/12 (0%) 2/13 (15%) 1/9 (11%) |
|FIRST INCIDENCE | 63 --- 5 167 85 98 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.033 * P=0.500N P=0.309 P=0.335 P=0.212 P=0.164 |
|POLY 3 | P=0.034 * P=0.498N P=0.326 P=0.326 P=0.187 P=0.139 |
|POLY 1.5 | P=0.037 * P=0.499N P=0.320 P=0.320 P=0.181 P=0.145 |
|POLY 6 | P=0.030 * P=0.496N P=0.331 P=0.331 P=0.191 P=0.132 |
|LOGISTIC REGRESSION| P=0.108 (e) P=0.164 P=0.100 P=0.067 P=0.217 |
|COCH-ARM / FISHERS | P=0.047 * P=0.500N P=0.299 P=0.299 P=0.165 P=0.165 |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 51
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) |
|POLY-3 RATE (b) | 0/13.43 0/14.34 0/15.00 0/15.00 0/14.39 0/13.53 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/15 (0%) 0/15 (0%) 0/12 (0%) 0/10 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 2/15 (13%) 0/15 (0%) |
|POLY-3 RATE (b) | 0/12.95 0/14.05 0/12.72 0/14.49 2/14.03 0/10.72 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 14.3% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/12 (0%) 0/12 (0%) 2/13 (15%) 0/9 (0%) |
|FIRST INCIDENCE | --- --- --- --- 186 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.351 (e) (e) (e) P=0.253 (e) |
|POLY 3 | P=0.247 (e) (e) (e) P=0.250 (e) |
|POLY 1.5 | P=0.301 (e) (e) (e) P=0.246 (e) |
|POLY 6 | P=0.198 (e) (e) (e) P=0.251 (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) P=0.253 (e) |
|COCH-ARM / FISHERS | P=0.414 (e) (e) (e) P=0.241 (e) |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 52
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Stomach, Forestomach: Epithelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 1/15 (7%) 0/15 (0%) 0/15 (0%) 0/15 (0%) |
|POLY-3 RATE (b) | 0/13.43 0/14.34 1/15.00 0/15.00 0/14.39 0/13.53 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 6.7% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 1/15 (7%) 0/15 (0%) 0/12 (0%) 0/10 (0%) |
|FIRST INCIDENCE | --- --- 185 (T) --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.608N (e) P=0.545 (e) (e) (e) |
|POLY 3 | P=0.541N (e) P=0.522 (e) (e) (e) |
|POLY 1.5 | P=0.549N (e) P=0.513 (e) (e) (e) |
|POLY 6 | P=0.531N (e) P=0.533 (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) P=0.545 (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.561N (e) P=0.500 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Stomach, Forestomach: Epithelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/15 (7%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 2/15 (13%) 0/15 (0%) |
|POLY-3 RATE (b) | 1/12.95 0/14.05 0/12.72 0/14.49 2/14.03 0/10.72 |
|POLY-3 PERCENT (g) | 7.7% 0.0% 0.0% 0.0% 14.3% 0.0% |
|TERMINAL (d) | 1/12 (8%) 0/14 (0%) 0/12 (0%) 0/12 (0%) 2/13 (15%) 0/9 (0%) |
|FIRST INCIDENCE | 186 (T) --- --- --- 186 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.588 P=0.469N P=0.500N P=0.500N P=0.529 P=0.557N |
|POLY 3 | P=0.498 P=0.484N P=0.504N P=0.478N P=0.528 P=0.538N |
|POLY 1.5 | P=0.550 P=0.488N P=0.503N P=0.480N P=0.524 P=0.523N |
|POLY 6 | P=0.446 P=0.481N P=0.507N P=0.480N P=0.530 P=0.553N |
|LOGISTIC REGRESSION| P=0.588 (e) (e) (e) P=0.529 (e) |
|COCH-ARM / FISHERS | P=0.646 P=0.500N P=0.500N P=0.500N P=0.500 P=0.500N |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 53
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Testes |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/15 (13%) 1/15 (7%) 0/15 (0%) 1/15 (7%) 1/15 (7%) 0/15 (0%) |
|POLY-3 RATE (b) | 2/13.43 1/14.34 0/15.00 1/15.00 1/14.39 0/13.53 |
|POLY-3 PERCENT (g) | 14.9% 7.0% 0.0% 6.7% 7.0% 0.0% |
|TERMINAL (d) | 2/12 (17%) 1/14 (7%) 0/15 (0%) 1/15 (7%) 1/12 (8%) 0/10 (0%) |
|FIRST INCIDENCE | 185 (T) 185 (T) --- 185 (T) 185 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.290N P=0.445N P=0.188N P=0.420N P=0.500N P=0.276N |
|POLY 3 | P=0.251N P=0.477N P=0.206N P=0.461N P=0.475N P=0.228N |
|POLY 1.5 | P=0.242N P=0.487N P=0.216N P=0.477N P=0.485N P=0.229N |
|POLY 6 | P=0.264N P=0.463N P=0.195N P=0.441N P=0.467N P=0.231N |
|LOGISTIC REGRESSION| P=0.290N P=0.445N (e) P=0.420N P=0.500N (e) |
|COCH-ARM / FISHERS | P=0.230N P=0.500N P=0.241N P=0.500N P=0.500N P=0.241N |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Testes |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | |
|POLY-3 RATE (b) | |
|POLY-3 PERCENT (g) | |
|TERMINAL (d) | |
|FIRST INCIDENCE | |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | |
|POLY 3 | |
|POLY 1.5 | |
|POLY 6 | |
|LOGISTIC REGRESSION| |
|COCH-ARM / FISHERS | |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 54
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Testes: Unilateral, Germinal Epithelium |
| Degeneration |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/15 (7%) 1/15 (7%) 0/15 (0%) 2/15 (13%) 1/15 (7%) 4/15 (27%) |
|POLY-3 RATE (b) | 1/13.95 1/14.34 0/15.00 2/15.00 1/14.39 4/14.38 |
|POLY-3 PERCENT (g) | 7.2% 7.0% 0.0% 13.3% 7.0% 27.8% |
|TERMINAL (d) | 0/12 (0%) 1/14 (7%) 0/15 (0%) 2/15 (13%) 1/12 (8%) 2/10 (20%) |
|FIRST INCIDENCE | 145 185 (T) --- 185 (T) 185 (T) 138 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.013 * P=0.743N P=0.486N P=0.560 P=0.753N P=0.170 |
|POLY 3 | P=0.024 * P=0.755N P=0.486N P=0.526 P=0.754N P=0.170 |
|POLY 1.5 | P=0.024 * P=0.757N P=0.491N P=0.515 P=0.756N P=0.168 |
|POLY 6 | P=0.022 * P=0.751N P=0.479N P=0.538 P=0.753N P=0.170 |
|LOGISTIC REGRESSION| P=0.033 * P=0.732 P=0.981N P=0.310 P=0.653 P=0.111 |
|COCH-ARM / FISHERS | P=0.025 * P=0.759N P=0.500N P=0.500 P=0.759N P=0.165 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Testes: Unilateral, Germinal Epithelium |
| Degeneration |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | |
|POLY-3 RATE (b) | |
|POLY-3 PERCENT (g) | |
|TERMINAL (d) | |
|FIRST INCIDENCE | |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | |
|POLY 3 | |
|POLY 1.5 | |
|POLY 6 | |
|LOGISTIC REGRESSION| |
|COCH-ARM / FISHERS | |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 55
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Thymus |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 4/15 (27%) 1/15 (7%) 2/15 (13%) 0/15 (0%) 4/14 (29%) 5/14 (36%) |
|POLY-3 RATE (b) | 4/15.00 1/14.34 2/15.00 0/15.00 4/13.68 5/14.00 |
|POLY-3 PERCENT (g) | 26.7% 7.0% 13.3% 0.0% 29.2% 35.7% |
|TERMINAL (d) | 1/12 (8%) 1/14 (7%) 2/15 (13%) 0/15 (0%) 2/11 (18%) 1/10 (10%) |
|FIRST INCIDENCE | 132 185 (T) 185 (T) --- 166 138 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.042 * P=0.165N P=0.274N P=0.053N P=0.628N P=0.490 |
|POLY 3 | P=0.046 * P=0.177N P=0.327N P=0.045N* P=0.601 P=0.452 |
|POLY 1.5 | P=0.045 * P=0.171N P=0.327N P=0.045N* P=0.607 P=0.452 |
|POLY 6 | P=0.047 * P=0.182N P=0.327N P=0.045N* P=0.591 P=0.452 |
|LOGISTIC REGRESSION| P=0.058 P=0.237N P=0.274N (e) P=0.410 (e) |
|COCH-ARM / FISHERS | P=0.047 * P=0.165N P=0.326N P=0.050N P=0.617 P=0.450 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Thymus |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/15 (20%) 0/15 (0%) 2/15 (13%) 2/14 (14%) 3/14 (21%) 6/15 (40%) |
|POLY-3 RATE (b) | 3/15.00 0/14.05 2/14.00 2/13.91 3/14.00 6/14.66 |
|POLY-3 PERCENT (g) | 20.0% 0.0% 14.3% 14.4% 21.4% 40.9% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/12 (0%) 0/11 (0%) 1/12 (8%) 1/9 (11%) |
|FIRST INCIDENCE | 63 --- 109 167 85 27 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.009 ** P=0.120N P=0.507N P=0.468N P=0.625N P=0.207 |
|POLY 3 | P=0.012 * P=0.118N P=0.533N P=0.536N P=0.637 P=0.202 |
|POLY 1.5 | P=0.012 * P=0.116N P=0.533N P=0.534N P=0.637 P=0.208 |
|POLY 6 | P=0.011 * P=0.119N P=0.533N P=0.539N P=0.637 P=0.194 |
|LOGISTIC REGRESSION| P=0.035 * P=0.136N P=0.485N (e) (e) P=0.778N |
|COCH-ARM / FISHERS | P=0.011 * P=0.112N P=0.500N P=0.535N P=0.639 P=0.213 |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 56
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Thymus |
| Myelodysplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/14 (0%) 3/14 (21%) |
|POLY-3 RATE (b) | 0/13.43 0/14.34 0/15.00 0/15.00 0/13.39 3/12.75 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 23.5% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/15 (0%) 0/15 (0%) 0/11 (0%) 3/10 (30%) |
|FIRST INCIDENCE | --- --- --- --- --- 185 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) (e) P=0.083 |
|POLY 3 | P<0.001 ** (e) (e) (e) (e) P=0.093 |
|POLY 1.5 | P<0.001 ** (e) (e) (e) (e) P=0.093 |
|POLY 6 | P<0.001 ** (e) (e) (e) (e) P=0.092 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) P=0.083 |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) (e) (e) P=0.100 |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Thymus |
| Myelodysplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/14 (0%) 0/14 (0%) 0/15 (0%) |
|POLY-3 RATE (b) | 0/12.95 0/14.05 0/12.72 0/13.49 0/13.03 0/10.72 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/12 (0%) 0/11 (0%) 0/12 (0%) 0/9 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 57
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Thymus: Thymocyte |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 2/14 (14%) 0/14 (0%) |
|POLY-3 RATE (b) | 0/13.43 0/14.34 0/15.00 0/15.00 2/13.72 0/12.75 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 14.6% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/15 (0%) 0/15 (0%) 0/11 (0%) 0/10 (0%) |
|FIRST INCIDENCE | --- --- --- --- 163 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.382 (e) (e) (e) P=0.273 (e) |
|POLY 3 | P=0.355 (e) (e) (e) P=0.235 (e) |
|POLY 1.5 | P=0.373 (e) (e) (e) P=0.227 (e) |
|POLY 6 | P=0.328 (e) (e) (e) P=0.245 (e) |
|LOGISTIC REGRESSION| P=0.406 (e) (e) (e) P=0.162 (e) |
|COCH-ARM / FISHERS | P=0.397 (e) (e) (e) P=0.224 (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Thymus: Thymocyte |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/15 (0%) 1/15 (7%) 2/15 (13%) 2/14 (14%) 0/14 (0%) 5/15 (33%) |
|POLY-3 RATE (b) | 0/12.95 1/15.00 2/14.20 2/13.86 0/13.03 5/13.31 |
|POLY-3 PERCENT (g) | 0.0% 6.7% 14.1% 14.4% 0.0% 37.6% |
|TERMINAL (d) | 0/12 (0%) 0/14 (0%) 0/12 (0%) 0/11 (0%) 0/12 (0%) 1/9 (11%) |
|FIRST INCIDENCE | --- 67 5 167 --- 98 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.007 ** P=0.514 P=0.240 P=0.265 (e) P=0.026 * |
|POLY 3 | P=0.008 ** P=0.529 P=0.253 P=0.247 (e) P=0.017 * |
|POLY 1.5 | P=0.009 ** P=0.523 P=0.249 P=0.241 (e) P=0.017 * |
|POLY 6 | P=0.008 ** P=0.532 P=0.254 P=0.248 (e) P=0.017 * |
|LOGISTIC REGRESSION| P=0.028 * P=0.327 P=0.244 P=0.198 (e) P=0.032 * |
|COCH-ARM / FISHERS | P=0.011 * P=0.500 P=0.241 P=0.224 (e) P=0.021 * |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 58
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Uterus |
| Hydrometra |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | |
|POLY-3 RATE (b) | |
|POLY-3 PERCENT (g) | |
|TERMINAL (d) | |
|FIRST INCIDENCE | |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | |
|POLY 3 | |
|POLY 1.5 | |
|POLY 6 | |
|LOGISTIC REGRESSION| |
|COCH-ARM / FISHERS | |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Uterus |
| Hydrometra |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/15 (7%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 0/15 (0%) 2/15 (13%) |
|POLY-3 RATE (b) | 1/12.95 0/14.05 0/12.72 0/14.49 0/14.03 2/10.72 |
|POLY-3 PERCENT (g) | 7.7% 0.0% 0.0% 0.0% 0.0% 18.7% |
|TERMINAL (d) | 1/12 (8%) 0/14 (0%) 0/12 (0%) 0/12 (0%) 0/13 (0%) 2/9 (22%) |
|FIRST INCIDENCE | 186 (T) --- --- --- --- 186 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.051 P=0.469N P=0.500N P=0.500N P=0.484N P=0.396 |
|POLY 3 | P=0.082 P=0.484N P=0.504N P=0.478N P=0.484N P=0.432 |
|POLY 1.5 | P=0.083 P=0.488N P=0.503N P=0.480N P=0.487N P=0.458 |
|POLY 6 | P=0.082 P=0.481N P=0.507N P=0.480N P=0.483N P=0.405 |
|LOGISTIC REGRESSION| P=0.051 (e) (e) (e) (e) P=0.396 |
|COCH-ARM / FISHERS | P=0.091 P=0.500N P=0.500N P=0.500N P=0.500N P=0.500 |
|=================================================================================================================================|
Date: 07/12/02 EXPERIMENT: 88127 TEST: 06 Page 59
Statistical Analysis of Non-neoplastic Lesions in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - PENTAERYTHRITOL TRIACRYLATE (
PETA)
Terminal Sacrifice at 27 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Uterus: Endometrium |
| Hyperplasia Cystic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | |
|POLY-3 RATE (b) | |
|POLY-3 PERCENT (g) | |
|TERMINAL (d) | |
|FIRST INCIDENCE | |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | |
|POLY 3 | |
|POLY 1.5 | |
|POLY 6 | |
|LOGISTIC REGRESSION| |
|COCH-ARM / FISHERS | |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/KG 0.75 1.5 3 MG/KG 6 MG/KG 12 MG/KG |
| | MG/KG MG/KG |
|=================================================================================================================================|
| |
|Uterus: Endometrium |
| Hyperplasia Cystic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 11/15 (73%) 9/15 (60%) 7/15 (47%) 10/15 (67%) 11/15 (73%) 7/15 (47%) |
|POLY-3 RATE (b) | 11/12.95 9/14.05 7/12.72 10/14.49 11/14.10 7/10.72 |
|POLY-3 PERCENT (g) | 84.9% 64.1% 55.1% 69.0% 78.0% 65.3% |
|TERMINAL (d) | 11/12 (92%) 9/14 (64%) 7/12 (58%) 10/12 (83%) 10/13 (77%) 7/9 (78%) |
|FIRST INCIDENCE | 186 (T) 186 (T) 186 (T) 186 (T) 182 186 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.422 P=0.123N P=0.083N P=0.500N P=0.516N P=0.396N |
|POLY 3 | P=0.532N P=0.212N P=0.101N P=0.295N P=0.514N P=0.250N |
|POLY 1.5 | P=0.420N P=0.241N P=0.105N P=0.325N P=0.546N P=0.175N |
|POLY 6 | P=0.470 P=0.193N P=0.108N P=0.305N P=0.492N P=0.372N |
|LOGISTIC REGRESSION| P=0.433 P=0.123N P=0.083N P=0.500N P=0.450N P=0.396N |
|COCH-ARM / FISHERS | P=0.249N P=0.350N P=0.132N P=0.500N P=0.659N P=0.132N |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Number of tumor-bearing animals / Poly-3 number
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death.
Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e) Value of Statistic cannot be computed.
(g) Poly-3 adjusted lifetime tumor incidence.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).