TDMS Study 89002-02 Pathology Tables
NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 10:54:39
Control vs Stop Study
Facility: Battelle Columbus Laboratory
Chemical CAS #: 87-86-5
Lock Date: 07/13/95
Cage Range: All
Reasons For Removal: 25019 Moribund Sacrifice 25020 Natural Death
25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include 001 0 PPM
Include 002 0 PPM
Include 009 1000 PPM
Include 010 1000 PPM
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 10:54:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 1000 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60
Early Deaths
Moribund Sacrifice 15 17
Natural Death 7 5
Survivors
Terminal Sacrifice 28 28
Animals Examined Microscopically 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (50)
Intestine Small, Duodenum (50) (50)
Intestine Small, Jejunum (50) (50)
Leiomyoma 1 (2%)
Intestine Small, Ileum (50) (50)
Liver (50) (50)
Sarcoma Stromal, Metastatic, Uterus 1 (2%)
Mesentery (8) (6)
Schwannoma Malignant, Metastatic, Uterus 1 (13%)
Fat, Sarcoma Stromal, Metastatic, Uterus 1 (17%)
Oral Mucosa (1) (2)
Pharyngeal, Squamous Cell Carcinoma 1 (50%)
Pharyngeal, Squamous Cell Papilloma 1 (100%)
Pancreas (50) (50)
Sarcoma Stromal, Metastatic, Uterus 1 (2%)
Acinus, Adenoma 1 (2%)
Salivary Glands (50) (50)
Stomach, Forestomach (50) (50)
Stomach, Glandular (50) (50)
Tongue (1) (1)
Squamous Cell Papilloma 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50)
____________________________________________________________________________________________________________________________________
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NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 10:54:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 1000 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50)
Adrenal Medulla (50) (50)
Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (50) (50)
Adenoma 1 (2%)
Parathyroid Gland (46) (45)
Adenoma 1 (2%)
Pituitary Gland (50) (50)
Pars Distalis, Adenoma 22 (44%) 18 (36%)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (50) (50)
Bilateral, C-Cell, Adenoma 2 (4%)
C-Cell, Adenoma 3 (6%) 5 (10%)
C-Cell, Carcinoma 2 (4%) 1 (2%)
Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (50) (49)
Adenoma 4 (8%) 5 (10%)
Carcinoma 1 (2%) 1 (2%)
Bilateral, Carcinoma 1 (2%)
Ovary (50) (50)
Uterus (50) (50)
Polyp Stromal 6 (12%) 6 (12%)
Sarcoma Stromal 1 (2%)
Schwannoma Malignant, Metastatic, Uterus 1 (2%)
Vagina (2)
Schwannoma Malignant, Metastatic, Uterus 1 (50%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (49)
Lymph Node (35) (30)
Deep Cervical, Carcinoma, Metastatic,
Thyroid Gland 1 (3%)
Lymph Node, Mandibular (50) (50)
Lymph Node, Mesenteric (50) (50)
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NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 10:54:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 1000 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont
Sarcoma Stromal, Metastatic, Uterus 1 (2%)
Spleen (50) (50)
Thymus (48) (49)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50)
Carcinoma 1 (2%)
Fibroadenoma 16 (32%) 10 (20%)
Fibroadenoma, Multiple 9 (18%) 5 (10%)
Skin (50) (50)
Subcutaneous Tissue, Fibroma 2 (4%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50)
Cranial Nerve, Squamous Cell Carcinoma,
Metastatic, Oral Mucosa 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50)
Alveolar/Bronchiolar Adenoma 2 (4%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Carcinoma, Metastatic, Clitoral Gland 1 (2%)
Nose (50) (50)
Squamous Cell Carcinoma, Metastatic, Oral
Mucosa 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
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NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 10:54:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 1000 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50)
Urinary Bladder (50) (49)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50)
Leukemia Mononuclear 15 (30%) 11 (22%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
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NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 10:54:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 1000 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 45 42
Total Primary Neoplasms 93 71
Total Animals with Benign Neoplasms 37 35
Total Benign Neoplasms 70 55
Total Animals with Malignant Neoplasms 20 16
Total Malignant Neoplasms 23 16
Total Animals with Metastatic Neoplasms 1 4
Total Metastatic Neoplasm 3 8
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 10:54:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 1000 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60
Early Deaths
Moribund Sacrifice 28 17
Natural Death 10 6
Survivors
Natural Death 1
Terminal Sacrifice 11 27
Animals Examined Microscopically 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (49)
Leiomyoma 1 (2%)
Intestine Large, Cecum (50) (49)
Polyp Adenomatous 1 (2%)
Intestine Small, Duodenum (50) (50)
Intestine Small, Jejunum (49) (50)
Carcinoma 1 (2%)
Intestine Small, Ileum (49) (49)
Carcinoma 1 (2%)
Carcinoma, Metastatic, Intestine Small,
Jejunum 1 (2%)
Liver (50) (50)
Mesentery (15) (15)
Fat, Sarcoma 1 (7%)
Oral Mucosa (1) (2)
Squamous Cell Papilloma 1 (50%)
Gingival, Squamous Cell Carcinoma,
Metastatic, Nose 1 (50%)
Pharyngeal, Squamous Cell Papilloma 1 (100%)
Pancreas (50) (50)
Acinus, Adenoma 2 (4%)
Salivary Glands (50) (50)
Stomach, Glandular (50) (50)
Tongue (1) (1)
Squamous Cell Papilloma 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
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NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 10:54:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 1000 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50)
Adenoma 1 (2%)
Adrenal Medulla (50) (50)
Pheochromocytoma Malignant 1 (2%) 3 (6%)
Pheochromocytoma Complex 1 (2%)
Pheochromocytoma Benign 7 (14%) 12 (24%)
Bilateral, Pheochromocytoma Benign 7 (14%) 4 (8%)
Islets, Pancreatic (50) (50)
Adenoma 1 (2%)
Parathyroid Gland (47) (47)
Adenoma 1 (2%)
Pituitary Gland (50) (50)
Pars Distalis, Adenoma 18 (36%) 16 (32%)
Thyroid Gland (50) (50)
C-Cell, Adenoma 5 (10%) 4 (8%)
Follicular Cell, Adenoma 2 (4%)
Follicular Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (2)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50)
Preputial Gland (50) (49)
Adenoma 4 (8%) 4 (8%)
Carcinoma 1 (2%) 2 (4%)
Prostate (50) (50)
Seminal Vesicle (50) (50)
Testes (50) (50)
Bilateral, Interstitial Cell, Adenoma 34 (68%) 38 (76%)
Interstitial Cell, Adenoma 8 (16%) 7 (14%)
____________________________________________________________________________________________________________________________________
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NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 10:54:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 1000 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50)
Lymph Node (34) (28)
Mediastinal, Sarcoma, Metastatic, Mesentery 1 (3%)
Lymph Node, Mandibular (50) (50)
Lymph Node, Mesenteric (50) (50)
Spleen (50) (50)
Thymus (49) (48)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (49)
Fibroadenoma 5 (10%) 2 (4%)
Skin (50) (50)
Basal Cell Adenoma 1 (2%) 2 (4%)
Keratoacanthoma 6 (12%)
Keratoacanthoma, Multiple 1 (2%)
Squamous Cell Papilloma 2 (4%)
Trichoepithelioma 2 (4%)
Subcutaneous Tissue, Fibroma 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibroma, Multiple 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 2 (4%) 1 (2%)
Subcutaneous Tissue, Fibrous Histiocytoma 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50)
Vertebra, Hemangiosarcoma 1 (2%)
Skeletal Muscle (1)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50)
Astrocytoma Malignant 1 (2%)
Oligodendroglioma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50)
Carcinoma, Metastatic, Harderian Gland 1 (2%)
Nose (50) (50)
Squamous Cell Carcinoma 1 (2%) 5 (10%)
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NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 10:54:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 1000 PPM
____________________________________________________________________________________________________________________________________
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50)
Renal Tubule, Adenoma 1 (2%) 2 (4%)
Renal Tubule, Oncocytoma Benign 1 (2%)
Urinary Bladder (48) (49)
Transitional Epithelium, Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50)
Leukemia Mononuclear 25 (50%) 15 (30%)
Mesothelioma Malignant 1 (2%) 9 (18%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 89002-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC PENTACHLOROPHENOL Date: 08/19/97
Route: DOSED FEED Time: 10:54:39
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 1000 PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 50 49
Total Primary Neoplasms 135 152
Total Animals with Benign Neoplasms 48 47
Total Benign Neoplasms 100 110
Total Animals with Malignant Neoplasms 32 29
Total Malignant Neoplasms 35 42
Total Animals with Metastatic Neoplasms 1 3
Total Metastatic Neoplasm 1 3
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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