TDMS Study 89002-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Battelle Columbus PENTACHLOROPHENOL DATE: 09/15/97
EXPERIMENT: 89002 TEST: 02 TIME: 16:47:38
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE:
CONT: NO1-ES-15322 ROUTE: DOSED FEED NTP C#: C89002
PATHOLOGIST: TOFT, J. CAS: 87-86-5
Rats(FISCHER344)
-----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Gland
Adrenal Medulla
Bone Marrow
Brain
Clitoral Gland
Clitoral/Preputial Gland
Epididymis
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Battelle Columbus PENTACHLOROPHENOL DATE: 09/15/97
EXPERIMENT: 89002 TEST: 02 TIME: 16:47:38
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE:
CONT: NO1-ES-15322 ROUTE: DOSED FEED NTP C#: C89002
PATHOLOGIST: TOFT, J. CAS: 87-86-5
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF PENTACHLOROPHENOL
===============================================================
Male Rats
------------
Organ Morphology
----- ----------
Adrenal Cortex Degeneration Fatty
Hypertrophy
Adrenal Medulla Hyperplasia
Bone Marrow Hyperplasia
Heart Cardiomyopathy Chronic
Heart: Atrium Thrombosis
Kidney Mineralization
Nephropathy Chronic
Kidney: Renal Tubule Pigmentation
Liver Basophilic Focus
Clear Cell Focus
Eosinophilic Focus
Hepatodiaphragmatic Nodule
Inflammation Chronic
Mixed Cell Focus
Liver: Artery Inflammation Chronic
Liver: Bile Duct Hyperplasia
Liver: Centrilobular Hypertrophy
Liver: Hepatocyte Degeneration Cystic
Vacuolization Cytoplasmic
Liver: Hepatocyte, Centrilobular Hypertrophy
Lung Inflammation Chronic
Lung: Alveolus Infiltration Cellular Histiocyte
Lymph Node, Mediastinal Pigmentation Hemosiderin
Lymph Node, Mesenteric Ectasia
Hyperplasia Lymphoid
Mammary Gland Hyperplasia Cystic
Mesentery: Fat Necrosis
Nose Fungus
Inflammation Chronic
Nose: Respiratory Epithelium Hyperplasia
Metaplasia
Pancreas: Acinus Atrophy
Parathyroid Gland Hyperplasia
Pituitary Gland: Pars Distalis Hyperplasia
Preputial Gland Hyperplasia
Inflammation Chronic
Prostate Inflammation Chronic
Skin: Epidermis Hyperkeratosis
Spleen Fibrosis
Hematopoietic Cell Proliferation
Stomach, Forestomach Inflammation Chronic
Stomach, Forestomach: Epithelium Hyperplasia
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Battelle Columbus PENTACHLOROPHENOL DATE: 09/15/97
EXPERIMENT: 89002 TEST: 02 TIME: 16:47:38
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE:
CONT: NO1-ES-15322 ROUTE: DOSED FEED NTP C#: C89002
PATHOLOGIST: TOFT, J. CAS: 87-86-5
Ulcer
Testes: Interstitial Cell Hyperplasia
Thyroid Gland: C-Cell Hyperplasia
===============================================================
Female Rats
------------
Organ Morphology
----- ----------
Adrenal Cortex Degeneration Cystic
Degeneration Fatty
Hyperplasia
Hypertrophy
Bone Osteopetrosis
Bone Marrow Hyperplasia
Brain Hemorrhage
Clitoral Gland Inflammation Chronic
Eye: Lens Cataract
Eye: Retina Atrophy
Heart Cardiomyopathy Chronic
Intestine Large, Colon Parasite Metazoan
Intestine Large, Rectum Parasite Metazoan
Kidney Mineralization
Nephropathy Chronic
Kidney: Renal Tubule Pigmentation
Liver Basophilic Focus
Clear Cell Focus
Liver: Centrilobular Hypertrophy
Liver: Hepatocyte Necrosis
Vacuolization Cytoplasmic
Liver: Hepatocyte, Centrilobular Hypertrophy
Lung: Alveolus Infiltration Cellular Histiocyte
Lymph Node, Mediastinal Pigmentation Hemosiderin
Mammary Gland Cyst
Hyperplasia Cystic
Nose Fungus
Inflammation Chronic
Nose: Respiratory Epithelium Hyperplasia
Metaplasia
Pituitary Gland: Pars Distalis Cyst
Thyroid Gland: C-Cell Hyperplasia
===============================================================
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 1
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Accessory Adrenal Cortical Nodule |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 1/50 (2%) 2/50 (4%) 2/60 (3%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 2.6% 4.6% 4.7% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 1/21 (5%) 2/31 (7%) 0/27 (0%) |
|FIRST INCIDENCE | --- --- 736 (T) 736 (T) 565 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.126 (e) P=0.612 P=0.463 P=0.273 |
|POLY 3 | P=0.078 (e) P=0.503 P=0.273 P=0.266 |
|POLY 1.5 | P=0.068 (e) P=0.496 P=0.249 P=0.251 |
|POLY 6 | P=0.100 (e) P=0.508 P=0.301 P=0.291 |
|LOGISTIC REGRESSION| P=0.072 (e) P=0.612 P=0.463 P=0.242 |
|COCH-ARM / FISHERS | P=0.069 (e) P=0.455 P=0.204 P=0.248 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Accessory Adrenal Cortical Nodule |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/60 (2%) 2/50 (4%) 0/50 (0%) 0/50 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 2.4% 4.7% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/28 (4%) 2/33 (6%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | 738 (T) 738 (T) --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.115N P=0.558 P=0.461N P=0.500N P=0.500N |
|POLY 3 | P=0.098N P=0.513 P=0.492N P=0.503N P=0.493N |
|POLY 1.5 | P=0.101N P=0.495 P=0.501N P=0.506N P=0.498N |
|POLY 6 | P=0.098N P=0.529 P=0.485N P=0.505N P=0.489N |
|LOGISTIC REGRESSION| P=0.115N P=0.558 (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.117N P=0.431 P=0.545N P=0.545N P=0.500N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 2
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Degeneration Cystic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/60 (2%) 1/50 (2%) 1/50 (2%) 0/50 (0%) 1/60 (2%) |
|POLY-3 ADJUSTED (b)| 2.7% 2.8% 2.6% 0.0% 2.4% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/12 (8%) 1/16 (6%) 0/21 (0%) 0/31 (0%) 1/27 (4%) |
|FIRST INCIDENCE | 736 (T) 736 (T) 624 --- 736 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.343N P=0.698N P=0.704N P=0.311N P=0.571N |
|POLY 3 | P=0.459N P=0.753 P=0.755N P=0.471N P=0.737N |
|POLY 1.5 | P=0.477N P=0.751 P=0.758 P=0.490N P=0.750N |
|POLY 6 | P=0.440N P=0.753 P=0.748N P=0.449N P=0.715N |
|LOGISTIC REGRESSION| P=0.453N P=0.698N P=0.763 (e) P=0.571N |
|COCH-ARM / FISHERS | P=0.512N P=0.705 P=0.705 P=0.545N P=0.752N |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Degeneration Cystic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 4/50 (8%) 3/50 (6%) 0/50 (0%) 2/60 (3%) |
|POLY-3 ADJUSTED (b)| 0.0% 9.3% 7.0% 0.0% 4.6% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 4/33 (12%) 3/34 (9%) 0/28 (0%) 1/28 (4%) |
|FIRST INCIDENCE | --- 738 (T) 738 (T) --- 600 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.537 P=0.085 P=0.157 (e) P=0.250 |
|POLY 3 | P=0.510N P=0.065 P=0.126 (e) P=0.247 |
|POLY 1.5 | P=0.524N P=0.058 P=0.118 (e) P=0.241 |
|POLY 6 | P=0.505N P=0.072 P=0.133 (e) P=0.253 |
|LOGISTIC REGRESSION| P=0.565 P=0.085 P=0.157 (e) P=0.241 |
|COCH-ARM / FISHERS | P=0.575N P=0.040 * P=0.091 (e) P=0.248 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 3
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Degeneration Fatty |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 28/60 (47%) 19/50 (38%) 16/50 (32%) 20/50 (40%) 25/60 (42%) |
|POLY-3 ADJUSTED (b)| 63.0% 46.9% 38.1% 43.5% 53.9% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 8/12 (67%) 6/16 (38%) 6/21 (29%) 12/31 (39%) 12/27 (44%) |
|FIRST INCIDENCE | 396 507 443 518 360 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.020N* P=0.064N P=0.005N** P<0.001N** P=0.017N* |
|POLY 3 | P=0.316N P=0.089N P=0.013N* P=0.043N* P=0.246N |
|POLY 1.5 | P=0.391N P=0.093N P=0.017N* P=0.077N P=0.301N |
|POLY 6 | P=0.211N P=0.099N P=0.012N* P=0.024N* P=0.166N |
|LOGISTIC REGRESSION| P=0.342N P=0.096N P=0.024N* P=0.071N P=0.259N |
|COCH-ARM / FISHERS | P=0.418N P=0.236N P=0.085N P=0.306N P=0.357N |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Degeneration Fatty |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 9/60 (15%) 11/50 (22%) 17/50 (34%) 15/50 (30%) 14/60 (23%) |
|POLY-3 ADJUSTED (b)| 21.1% 25.5% 37.7% 35.6% 32.1% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 4/28 (14%) 10/33 (30%) 10/34 (29%) 11/28 (39%) 8/28 (29%) |
|FIRST INCIDENCE | 585 620 451 586 647 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.103 P=0.545 P=0.139 P=0.122 P=0.219 |
|POLY 3 | P=0.128 P=0.414 P=0.070 P=0.105 P=0.180 |
|POLY 1.5 | P=0.130 P=0.377 P=0.053 P=0.099 P=0.171 |
|POLY 6 | P=0.124 P=0.441 P=0.084 P=0.095 P=0.189 |
|LOGISTIC REGRESSION| P=0.131 P=0.440 P=0.053 P=0.106 P=0.197 |
|COCH-ARM / FISHERS | P=0.165 P=0.242 P=0.017 * P=0.048 * P=0.177 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 4
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 13/60 (22%) 11/50 (22%) 13/50 (26%) 15/50 (30%) 17/60 (28%) |
|POLY-3 ADJUSTED (b)| 32.0% 29.3% 33.1% 34.0% 39.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 4/12 (33%) 7/16 (44%) 8/21 (38%) 12/31 (39%) 13/27 (48%) |
|FIRST INCIDENCE | 564 524 605 619 460 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.218N P=0.313N P=0.291N P=0.088N P=0.280N |
|POLY 3 | P=0.217 P=0.493N P=0.557 P=0.516 P=0.328 |
|POLY 1.5 | P=0.172 P=0.483N P=0.542 P=0.435 P=0.290 |
|POLY 6 | P=0.305 P=0.541N P=0.544 P=0.590 P=0.389 |
|LOGISTIC REGRESSION| P=0.299 P=0.460N P=0.575N P=0.590N P=0.362 |
|COCH-ARM / FISHERS | P=0.162 P=0.574 P=0.378 P=0.218 P=0.264 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 7/60 (12%) 12/50 (24%) 23/50 (46%) 12/50 (24%) 17/60 (28%) |
|POLY-3 ADJUSTED (b)| 16.9% 28.0% 51.6% 29.1% 39.2% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 6/28 (21%) 12/33 (36%) 19/34 (56%) 10/28 (36%) 14/28 (50%) |
|FIRST INCIDENCE | 698 738 (T) 451 634 600 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.016 * P=0.255 P=0.003 ** P=0.141 P=0.016 * |
|POLY 3 | P=0.047 * P=0.166 P<0.001 ** P=0.142 P=0.018 * |
|POLY 1.5 | P=0.046 * P=0.140 P<0.001 ** P=0.134 P=0.016 * |
|POLY 6 | P=0.046 * P=0.192 P<0.001 ** P=0.135 P=0.020 * |
|LOGISTIC REGRESSION| P=0.033 * P=0.255 P<0.001 ** P=0.120 P=0.021 * |
|COCH-ARM / FISHERS | P=0.059 P=0.074 P<0.001 ** P=0.074 P=0.019 * |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 5
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Hypertrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 1/50 (2%) 2/50 (4%) 4/50 (8%) 3/60 (5%) |
|POLY-3 ADJUSTED (b)| 0.0% 2.7% 5.1% 9.2% 7.1% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 0/21 (0%) 4/31 (13%) 2/27 (7%) |
|FIRST INCIDENCE | --- 619 443 736 (T) 677 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.136 P=0.489 P=0.244 P=0.238 P=0.253 |
|POLY 3 | P=0.068 P=0.494 P=0.248 P=0.082 P=0.139 |
|POLY 1.5 | P=0.057 P=0.491 P=0.237 P=0.068 P=0.129 |
|POLY 6 | P=0.092 P=0.496 P=0.259 P=0.103 P=0.160 |
|LOGISTIC REGRESSION| P=0.058 P=0.468 P=0.095 P=0.238 P=0.164 |
|COCH-ARM / FISHERS | P=0.057 P=0.455 P=0.204 P=0.040 * P=0.122 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Hypertrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/60 (2%) 6/50 (12%) 8/50 (16%) 7/50 (14%) 3/60 (5%) |
|POLY-3 ADJUSTED (b)| 2.4% 14.0% 18.6% 17.2% 7.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/28 (4%) 6/33 (18%) 8/34 (24%) 7/28 (25%) 3/28 (11%) |
|FIRST INCIDENCE | 738 (T) 738 (T) 738 (T) 738 (T) 738 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.338 P=0.085 P=0.033 * P=0.029 * P=0.304 |
|POLY 3 | P=0.428 P=0.061 P=0.018 * P=0.027 * P=0.317 |
|POLY 1.5 | P=0.418 P=0.053 P=0.015 * P=0.026 * P=0.309 |
|POLY 6 | P=0.434 P=0.070 P=0.020 * P=0.025 * P=0.324 |
|LOGISTIC REGRESSION| P=0.338 P=0.085 P=0.033 * P=0.029 * P=0.304 |
|COCH-ARM / FISHERS | P=0.433 P=0.033 * P=0.007 ** P=0.016 * P=0.309 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 6
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 18/60 (30%) 27/50 (54%) 22/50 (44%) 25/50 (50%) 28/60 (47%) |
|POLY-3 ADJUSTED (b)| 46.0% 65.0% 51.8% 53.9% 61.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 6/12 (50%) 9/16 (56%) 9/21 (43%) 17/31 (55%) 17/27 (63%) |
|FIRST INCIDENCE | 647 563 521 544 460 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.145N P=0.167 P=0.477N P=0.118N P=0.396N |
|POLY 3 | P=0.268 P=0.054 P=0.376 P=0.301 P=0.111 |
|POLY 1.5 | P=0.161 P=0.037 * P=0.282 P=0.165 P=0.062 |
|POLY 6 | P=0.467 P=0.088 P=0.491 P=0.495 P=0.235 |
|LOGISTIC REGRESSION| P=0.183 P=0.023 * P=0.283 P=0.337 P=0.088 |
|COCH-ARM / FISHERS | P=0.105 P=0.009 ** P=0.093 P=0.026 * P=0.045 * |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 3/60 (5%) 7/50 (14%) 6/50 (12%) 7/50 (14%) 4/60 (7%) |
|POLY-3 ADJUSTED (b)| 7.3% 16.0% 13.6% 16.3% 9.1% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 3/28 (11%) 5/33 (15%) 4/34 (12%) 2/28 (7%) 2/28 (7%) |
|FIRST INCIDENCE | 738 (T) 430 399 417 516 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.488 P=0.223 P=0.327 P=0.163 P=0.509 |
|POLY 3 | P=0.521N P=0.181 P=0.274 P=0.172 P=0.533 |
|POLY 1.5 | P=0.539N P=0.157 P=0.247 P=0.156 P=0.515 |
|POLY 6 | P=0.506N P=0.206 P=0.297 P=0.180 P=0.552 |
|LOGISTIC REGRESSION| P=0.535 P=0.159 P=0.236 P=0.120 P=0.512 |
|COCH-ARM / FISHERS | P=0.545 P=0.097 P=0.163 P=0.097 P=0.500 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 7
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Blood Vessel: Aorta |
| Mineralization |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/60 (2%) 0/50 (0%) 0/50 (0%) 1/50 (2%) 2/60 (3%) |
|POLY-3 ADJUSTED (b)| 2.7% 0.0% 0.0% 2.3% 4.8% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 0/21 (0%) 1/31 (3%) 1/27 (4%) |
|FIRST INCIDENCE | 715 --- --- 736 (T) 684 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.305 P=0.490N P=0.462N P=0.591N P=0.670 |
|POLY 3 | P=0.191 P=0.508N P=0.497N P=0.726N P=0.538 |
|POLY 1.5 | P=0.182 P=0.510N P=0.504N P=0.749N P=0.518 |
|POLY 6 | P=0.210 P=0.510N P=0.493N P=0.699N P=0.570 |
|LOGISTIC REGRESSION| P=0.240 P=0.504N P=0.483N P=0.666N P=0.577 |
|COCH-ARM / FISHERS | P=0.191 P=0.545N P=0.545N P=0.705 P=0.500 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Blood Vessel: Aorta |
| Mineralization |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 8
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Bone |
| Fibrous Osteodystrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/60 (2%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 3/60 (5%) |
|POLY-3 ADJUSTED (b)| 2.7% 0.0% 0.0% 0.0% 7.1% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 0/21 (0%) 0/31 (0%) 1/27 (4%) |
|FIRST INCIDENCE | 715 --- --- --- 684 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.126 P=0.490N P=0.462N P=0.396N P=0.488 |
|POLY 3 | P=0.078 P=0.508N P=0.497N P=0.471N P=0.345 |
|POLY 1.5 | P=0.075 P=0.510N P=0.504N P=0.490N P=0.324 |
|POLY 6 | P=0.083 P=0.510N P=0.493N P=0.450N P=0.382 |
|LOGISTIC REGRESSION| P=0.091 P=0.504N P=0.483N P=0.440N P=0.384 |
|COCH-ARM / FISHERS | P=0.075 P=0.545N P=0.545N P=0.545N P=0.309 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Bone |
| Fibrous Osteodystrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/59 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 9
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Bone |
| Osteopetrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 1/50 (2%) 0/50 (0%) 0/50 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 2.7% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 0/21 (0%) 0/31 (0%) 0/27 (0%) |
|FIRST INCIDENCE | --- 614 --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.431N P=0.489 (e) (e) (e) |
|POLY 3 | P=0.388N P=0.495 (e) (e) (e) |
|POLY 1.5 | P=0.398N P=0.491 (e) (e) (e) |
|POLY 6 | P=0.384N P=0.496 (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.452N P=0.465 (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.451N P=0.455 (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Bone |
| Osteopetrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 6/60 (10%) 1/50 (2%) 4/50 (8%) 2/50 (4%) 2/59 (3%) |
|POLY-3 ADJUSTED (b)| 14.4% 2.3% 9.3% 4.9% 4.8% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 3/28 (11%) 0/33 (0%) 4/34 (12%) 1/28 (4%) 0/28 (0%) |
|FIRST INCIDENCE | 698 698 738 (T) 634 708 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.156N P=0.040N* P=0.273N P=0.154N P=0.127N |
|POLY 3 | P=0.169N P=0.051N P=0.349N P=0.135N P=0.128N |
|POLY 1.5 | P=0.163N P=0.058N P=0.374N P=0.142N P=0.136N |
|POLY 6 | P=0.179N P=0.045N* P=0.334N P=0.138N P=0.122N |
|LOGISTIC REGRESSION| P=0.141N P=0.048N* P=0.312N P=0.140N P=0.123N |
|COCH-ARM / FISHERS | P=0.143N P=0.091N P=0.491N P=0.203N P=0.142N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 10
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Bone Marrow |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 30/60 (50%) 33/50 (66%) 36/50 (72%) 32/50 (64%) 38/60 (63%) |
|POLY-3 ADJUSTED (b)| 67.4% 74.9% 77.7% 67.1% 79.1% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 5/12 (42%) 11/16 (69%) 16/21 (76%) 19/31 (61%) 21/27 (78%) |
|FIRST INCIDENCE | 396 435 360 518 360 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.048N* P=0.477 P=0.505N P=0.019N* P=0.181N |
|POLY 3 | P=0.242 P=0.281 P=0.180 P=0.579N P=0.138 |
|POLY 1.5 | P=0.169 P=0.244 P=0.124 P=0.452 P=0.098 |
|POLY 6 | P=0.356 P=0.279 P=0.207 P=0.475N P=0.199 |
|LOGISTIC REGRESSION| P=0.193 P=0.221 P=0.101 P=0.523 P=0.125 |
|COCH-ARM / FISHERS | P=0.155 P=0.067 P=0.015 * P=0.100 P=0.099 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Bone Marrow |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 11/60 (18%) 14/50 (28%) 17/50 (34%) 21/50 (42%) 16/59 (27%) |
|POLY-3 ADJUSTED (b)| 25.2% 31.4% 38.2% 45.1% 34.3% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 3/28 (11%) 6/33 (18%) 12/34 (35%) 9/28 (32%) 2/28 (7%) |
|FIRST INCIDENCE | 475 535 535 444 365 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.114 P=0.474 P=0.273 P=0.046 * P=0.263 |
|POLY 3 | P=0.149 P=0.342 P=0.137 P=0.036 * P=0.236 |
|POLY 1.5 | P=0.123 P=0.298 P=0.117 P=0.026 * P=0.200 |
|POLY 6 | P=0.180 P=0.383 P=0.146 P=0.043 * P=0.279 |
|LOGISTIC REGRESSION| P=0.110 P=0.279 P=0.123 P=0.010 * P=0.179 |
|COCH-ARM / FISHERS | P=0.126 P=0.164 P=0.049 * P=0.006 ** P=0.178 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 11
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Bone Marrow |
| Myelofibrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/60 (2%) 2/50 (4%) 0/50 (0%) 1/50 (2%) 1/60 (2%) |
|POLY-3 ADJUSTED (b)| 2.6% 5.5% 0.0% 2.3% 2.4% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 0/21 (0%) 0/31 (0%) 0/27 (0%) |
|FIRST INCIDENCE | 684 698 --- 708 708 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.340N P=0.516 P=0.500N P=0.645N P=0.672N |
|POLY 3 | P=0.442N P=0.486 P=0.498N P=0.726N P=0.738N |
|POLY 1.5 | P=0.459N P=0.483 P=0.504N P=0.749N P=0.750N |
|POLY 6 | P=0.420N P=0.485 P=0.494N P=0.699N P=0.717N |
|LOGISTIC REGRESSION| P=0.430N P=0.486 P=0.499N P=0.739N P=0.735N |
|COCH-ARM / FISHERS | P=0.489N P=0.431 P=0.545N P=0.705 P=0.752N |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Bone Marrow |
| Myelofibrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/60 (2%) 1/50 (2%) 0/50 (0%) 0/50 (0%) 0/59 (0%) |
|POLY-3 ADJUSTED (b)| 2.4% 2.3% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | 705 698 --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.166N P=0.722N P=0.470N P=0.513N P=0.488N |
|POLY 3 | P=0.156N P=0.752N P=0.492N P=0.503N P=0.498N |
|POLY 1.5 | P=0.156N P=0.758 P=0.501N P=0.506N P=0.502N |
|POLY 6 | P=0.159N P=0.741N P=0.486N P=0.506N P=0.494N |
|LOGISTIC REGRESSION| P=0.163N P=0.764N P=0.496N P=0.505N P=0.497N |
|COCH-ARM / FISHERS | P=0.168N P=0.705 P=0.545N P=0.545N P=0.504N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 12
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Brain |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 4/60 (7%) 0/50 (0%) 6/50 (12%) 2/50 (4%) 1/60 (2%) |
|POLY-3 ADJUSTED (b)| 10.2% 0.0% 14.7% 4.5% 2.4% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 0/21 (0%) 0/31 (0%) 1/27 (4%) |
|FIRST INCIDENCE | 564 --- 527 518 736 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.141N P=0.080N P=0.388 P=0.235N P=0.112N |
|POLY 3 | P=0.177N P=0.069N P=0.395 P=0.281N P=0.157N |
|POLY 1.5 | P=0.206N P=0.068N P=0.367 P=0.318N P=0.169N |
|POLY 6 | P=0.137N P=0.073N P=0.419 P=0.246N P=0.141N |
|LOGISTIC REGRESSION| P=0.222N P=0.079N P=0.248 P=0.439N P=0.167N |
|COCH-ARM / FISHERS | P=0.219N P=0.084N P=0.262 P=0.430N P=0.182N |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Brain |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 1/50 (2%) 0/50 (0%) 2/50 (4%) 1/60 (2%) |
|POLY-3 ADJUSTED (b)| 0.0% 2.3% 0.0% 4.7% 2.3% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | --- 392 --- 444 652 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.264 P=0.496 (e) P=0.237 P=0.520 |
|POLY 3 | P=0.261 P=0.511 (e) P=0.242 P=0.508 |
|POLY 1.5 | P=0.257 P=0.500 (e) P=0.235 P=0.503 |
|POLY 6 | P=0.267 P=0.521 (e) P=0.243 P=0.514 |
|LOGISTIC REGRESSION| P=0.335 P=0.268 (e) P=0.048 * P=0.502 |
|COCH-ARM / FISHERS | P=0.276 P=0.455 (e) P=0.204 P=0.500 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 13
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Clitoral Gland |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | |
|POLY-3 ADJUSTED (b)| |
|INT SACRIFICE 1 (c)| |
|TERMINAL (d) | |
|FIRST INCIDENCE | |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | |
|POLY 3 | |
|POLY 1.5 | |
|POLY 6 | |
|LOGISTIC REGRESSION| |
|COCH-ARM / FISHERS | |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Clitoral Gland |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 10/60 (17%) 12/50 (24%) 14/48 (29%) 11/50 (22%) 10/59 (17%) |
|POLY-3 ADJUSTED (b)| 23.6% 27.4% 33.5% 25.7% 23.9% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 6/28 (21%) 10/33 (30%) 13/34 (38%) 6/28 (21%) 9/27 (33%) |
|FIRST INCIDENCE | 523 535 600 586 703 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.523 P=0.554 P=0.410 P=0.487 P=0.587 |
|POLY 3 | P=0.467N P=0.434 P=0.220 P=0.509 P=0.587 |
|POLY 1.5 | P=0.462N P=0.387 P=0.191 P=0.480 P=0.578 |
|POLY 6 | P=0.485N P=0.477 P=0.241 P=0.514 P=0.592 |
|LOGISTIC REGRESSION| P=0.461N P=0.429 P=0.251 P=0.463 P=0.575N |
|COCH-ARM / FISHERS | P=0.428N P=0.236 P=0.094 P=0.320 P=0.580 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 14
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Clitoral Gland |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | |
|POLY-3 ADJUSTED (b)| |
|INT SACRIFICE 1 (c)| |
|TERMINAL (d) | |
|FIRST INCIDENCE | |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | |
|POLY 3 | |
|POLY 1.5 | |
|POLY 6 | |
|LOGISTIC REGRESSION| |
|COCH-ARM / FISHERS | |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Clitoral Gland |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 10/60 (17%) 11/50 (22%) 4/48 (8%) 5/50 (10%) 5/59 (8%) |
|POLY-3 ADJUSTED (b)| 20.6% 24.1% 9.3% 12.0% 11.4% |
|INT SACRIFICE 1 (c)| 6/10 (60%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 2/10 (20%) |
|TERMINAL (d) | 1/28 (4%) 6/33 (18%) 2/34 (6%) 3/28 (11%) 2/27 (7%) |
|FIRST INCIDENCE | 184 (I) 337 417 572 184 (I) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.034N* P=0.080 P=0.590N P=0.502 P=0.116N |
|POLY 3 | P=0.054N P=0.437 P=0.111N P=0.208N P=0.179N |
|POLY 1.5 | P=0.051N P=0.401 P=0.121N P=0.204N P=0.177N |
|POLY 6 | P=0.059N P=0.478 P=0.104N P=0.225N P=0.179N |
|LOGISTIC REGRESSION| P=0.026N* P=0.055 P=0.557 P=0.564 P=0.112N |
|COCH-ARM / FISHERS | P=0.039N* P=0.320 P=0.161N P=0.232N P=0.142N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 15
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Coagulating Gland |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 2/2 (100%) 1/1 (100%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |
|POLY-3 ADJUSTED (b)| 100.0% 100.0% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |
|TERMINAL (d) | 0/0 (0%) 1/1 (100%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 715 736 (T) --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Coagulating Gland |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |
|TERMINAL (d) | 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 16
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Epididymis |
| Granuloma Sperm |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 2/50 (4%) 0/50 (0%) 0/50 (0%) 1/60 (2%) |
|POLY-3 ADJUSTED (b)| 0.0% 5.4% 0.0% 0.0% 2.4% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 0/21 (0%) 0/31 (0%) 1/27 (4%) |
|FIRST INCIDENCE | --- 507 --- --- 736 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.590N P=0.229 (e) (e) P=0.662 |
|POLY 3 | P=0.594N P=0.233 (e) (e) P=0.521 |
|POLY 1.5 | P=0.611N P=0.228 (e) (e) P=0.510 |
|POLY 6 | P=0.578N P=0.235 (e) (e) P=0.539 |
|LOGISTIC REGRESSION| P=0.588 P=0.184 (e) (e) P=0.662 |
|COCH-ARM / FISHERS | P=0.586 P=0.204 (e) (e) P=0.500 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Epididymis |
| Granuloma Sperm |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | |
|POLY-3 ADJUSTED (b)| |
|INT SACRIFICE 1 (c)| |
|TERMINAL (d) | |
|FIRST INCIDENCE | |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | |
|POLY 3 | |
|POLY 1.5 | |
|POLY 6 | |
|LOGISTIC REGRESSION| |
|COCH-ARM / FISHERS | |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 17
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Eye |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/1 (0%) 0/4 (0%) 0/1 (0%) 0/3 (0%) 0/3 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |
|TERMINAL (d) | 0/0 (0%) 0/2 (0%) 0/1 (0%) 0/3 (0%) 0/1 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Eye |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 2/3 (67%) 0/3 (0%) 0/2 (0%) 0/2 (0%) 1/2 (50%) |
|POLY-3 ADJUSTED (b)| 70.3% 0.0% 0.0% 0.0% 50.0% |
|INT SACRIFICE 1 (c)| 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |
|TERMINAL (d) | 2/2 (100%) 0/2 (0%) 0/0 (0%) 0/1 (0%) 0/1 (0%) |
|FIRST INCIDENCE | 738 (T) --- --- --- 701 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.570N P=0.193N P=1.000N P=0.362N P=0.682N |
|POLY 3 | P=0.612N P=0.146N P=0.485N P=0.350N P=0.657N |
|POLY 1.5 | P=0.585N P=0.152N P=0.404N P=0.318N P=0.664N |
|POLY 6 | P=0.639N P=0.134N P=0.572N P=0.393N P=0.644N |
|LOGISTIC REGRESSION| P=0.601N (e) (e) (e) P=0.737N |
|COCH-ARM / FISHERS | P=0.539N P=0.200N P=0.300N P=0.300N P=0.700N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 18
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Eye: Lens |
| Cataract |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/1 (100%) 3/4 (75%) 0/1 (0%) 3/3 (100%) 3/3 (100%) |
|POLY-3 ADJUSTED (b)| 100.0% 77.1% 0.0% 100.0% 100.0% |
|INT SACRIFICE 1 (c)| 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |
|TERMINAL (d) | 0/0 (0%) 2/2 (100%) 0/1 (0%) 3/3 (100%) 1/1 (100%) |
|FIRST INCIDENCE | 396 592 --- 736 (T) 677 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.418 P=0.738 P=0.510N (e) (e) |
|POLY 3 | P=0.313 P=0.783N P=1.000 (e) (e) |
|POLY 1.5 | P=0.308 P=0.766N P=1.000 (e) (e) |
|POLY 6 | P=0.324 P=0.817N P=1.000 (e) (e) |
|LOGISTIC REGRESSION| P=0.228 (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.325 P=0.800N P=0.500N (e) (e) |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Eye: Lens |
| Cataract |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/3 (0%) 2/3 (67%) 2/2 (100%) 2/2 (100%) 0/2 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 70.3% 100.0% 100.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |
|TERMINAL (d) | 0/2 (0%) 2/2 (100%) 0/0 (0%) 1/1 (100%) 0/1 (0%) |
|FIRST INCIDENCE | --- 738 (T) 417 586 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.567 P=0.193 P=0.262 P=0.161 (e) |
|POLY 3 | P=0.574 P=0.146 P<0.001 ** P<0.001 ** (e) |
|POLY 1.5 | P=0.592 P=0.152 P<0.001 ** P<0.001 ** (e) |
|POLY 6 | P=0.535 P=0.134 P<0.001 ** P<0.001 ** (e) |
|LOGISTIC REGRESSION| P=0.630N P=0.193 (e) P=0.174 (e) |
|COCH-ARM / FISHERS | P=0.567 P=0.200 P=0.100 P=0.100 (e) |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 19
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Eye: Lens |
| Synechia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/1 (0%) 0/4 (0%) 0/1 (0%) 0/3 (0%) 0/3 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |
|TERMINAL (d) | 0/0 (0%) 0/2 (0%) 0/1 (0%) 0/3 (0%) 0/1 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Eye: Lens |
| Synechia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/3 (0%) 2/3 (67%) 0/2 (0%) 0/2 (0%) 0/2 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 66.7% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |
|TERMINAL (d) | 0/2 (0%) 1/2 (50%) 0/0 (0%) 0/1 (0%) 0/1 (0%) |
|FIRST INCIDENCE | --- 698 --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.363N P=0.258 (e) (e) (e) |
|POLY 3 | P=0.385N P=0.172 (e) (e) (e) |
|POLY 1.5 | P=0.358N P=0.165 (e) (e) (e) |
|POLY 6 | P=0.422N P=0.185 (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.389N P=0.186 (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.353N P=0.200 (e) (e) (e) |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 20
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Eye: Retina |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/1 (100%) 4/4 (100%) 0/1 (0%) 3/3 (100%) 3/3 (100%) |
|POLY-3 ADJUSTED (b)| 100.0% 100.0% 0.0% 100.0% 100.0% |
|INT SACRIFICE 1 (c)| 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |
|TERMINAL (d) | 0/0 (0%) 2/2 (100%) 0/1 (0%) 3/3 (100%) 1/1 (100%) |
|FIRST INCIDENCE | 396 592 --- 736 (T) 677 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.587 (e) P=0.510N (e) (e) |
|POLY 3 | P=1.000N (e) P=1.000 (e) (e) |
|POLY 1.5 | P=1.000N (e) P=1.000 (e) (e) |
|POLY 6 | P=1.000N (e) P=1.000 (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.620 (e) P=0.500N (e) (e) |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Eye: Retina |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/3 (0%) 3/3 (100%) 2/2 (100%) 2/2 (100%) 0/2 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 100.0% 100.0% 100.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |
|TERMINAL (d) | 0/2 (0%) 2/2 (100%) 0/0 (0%) 1/1 (100%) 0/1 (0%) |
|FIRST INCIDENCE | --- 698 417 586 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.514N P=0.104 P=0.262 P=0.161 (e) |
|POLY 3 | P=0.999N P<0.001 ** P<0.001 ** P<0.001 ** (e) |
|POLY 1.5 | P=1.000N P<0.001 ** P<0.001 ** P<0.001 ** (e) |
|POLY 6 | P=0.970N P<0.001 ** P<0.001 ** P<0.001 ** (e) |
|LOGISTIC REGRESSION| P=0.499N P=0.051 (e) P=0.174 (e) |
|COCH-ARM / FISHERS | P=0.579N P=0.050 P=0.100 P=0.100 (e) |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 21
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Heart |
| Cardiomyopathy Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 50/60 (83%) 41/50 (82%) 41/50 (82%) 44/50 (88%) 55/60 (92%) |
|POLY-3 ADJUSTED (b)| 89.8% 87.0% 89.0% 89.3% 95.2% |
|INT SACRIFICE 1 (c)| 9/10 (90%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 10/10 (100%) |
|TERMINAL (d) | 12/12 (100%) 15/16 (94%) 21/21 (100%) 27/31 (87%) 26/27 (96%) |
|FIRST INCIDENCE | 184 (I) 410 360 213 184 (I) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.004N** P=0.391N P=0.094N P<0.001N** P=0.019N* |
|POLY 3 | P=0.111 P=0.446N P=0.595N P=0.601N P=0.199 |
|POLY 1.5 | P=0.087 P=0.442N P=0.518N P=0.555 P=0.170 |
|POLY 6 | P=0.181 P=0.504N P=0.606 P=0.496N P=0.266 |
|LOGISTIC REGRESSION| P=0.069 P=0.513N P=0.427N P=0.364 P=0.138 |
|COCH-ARM / FISHERS | P=0.065 P=0.525N P=0.525N P=0.340 P=0.135 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Heart |
| Cardiomyopathy Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 29/60 (48%) 31/50 (62%) 36/50 (72%) 35/50 (70%) 26/60 (43%) |
|POLY-3 ADJUSTED (b)| 60.4% 66.8% 79.6% 77.2% 57.6% |
|INT SACRIFICE 1 (c)| 2/10 (20%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 1/10 (10%) |
|TERMINAL (d) | 15/28 (54%) 22/33 (67%) 29/34 (85%) 22/28 (79%) 17/28 (61%) |
|FIRST INCIDENCE | 184 (I) 284 535 459 184 (I) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.437N P=0.554 P=0.290 P=0.114 P=0.328N |
|POLY 3 | P=0.500N P=0.331 P=0.029 * P=0.055 P=0.473N |
|POLY 1.5 | P=0.434N P=0.279 P=0.029 * P=0.055 P=0.445N |
|POLY 6 | P=0.475 P=0.371 P=0.024 * P=0.042 * P=0.509N |
|LOGISTIC REGRESSION| P=0.284N P=0.248 P=0.072 P=0.073 P=0.329N |
|COCH-ARM / FISHERS | P=0.248N P=0.107 P=0.010 * P=0.017 * P=0.357N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 22
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Heart: Atrium |
| Thrombosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 7/60 (12%) 7/50 (14%) 4/50 (8%) 2/50 (4%) 1/60 (2%) |
|POLY-3 ADJUSTED (b)| 18.5% 18.4% 10.4% 4.6% 2.4% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 3/12 (25%) 1/16 (6%) 2/21 (10%) 1/31 (3%) 0/27 (0%) |
|FIRST INCIDENCE | 684 507 640 708 708 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001N** P=0.532N P=0.109N P=0.004N** P=0.003N** |
|POLY 3 | P=0.003N** P=0.614N P=0.245N P=0.049N* P=0.020N* |
|POLY 1.5 | P=0.004N** P=0.594 P=0.268N P=0.067N P=0.025N* |
|POLY 6 | P=0.002N** P=0.596N P=0.226N P=0.034N* P=0.014N* |
|LOGISTIC REGRESSION| P=0.002N** P=0.578 P=0.210N P=0.017N* P=0.008N** |
|COCH-ARM / FISHERS | P=0.006N** P=0.466 P=0.378N P=0.133N P=0.031N* |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Heart: Atrium |
| Thrombosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 1/50 (2%) 0/50 (0%) 0/50 (0%) 1/60 (2%) |
|POLY-3 ADJUSTED (b)| 0.0% 2.3% 0.0% 0.0% 2.3% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | --- 620 --- --- 668 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.408 P=0.514 (e) (e) P=0.527 |
|POLY 3 | P=0.433 P=0.509 (e) (e) P=0.508 |
|POLY 1.5 | P=0.426 P=0.498 (e) (e) P=0.503 |
|POLY 6 | P=0.438 P=0.520 (e) (e) P=0.513 |
|LOGISTIC REGRESSION| P=0.413 P=0.451 (e) (e) P=0.503 |
|COCH-ARM / FISHERS | P=0.413 P=0.455 (e) (e) P=0.500 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 23
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Intestine Large, Colon |
| Parasite Metazoan |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/60 (2%) 3/50 (6%) 1/50 (2%) 3/49 (6%) 3/59 (5%) |
|POLY-3 ADJUSTED (b)| 2.7% 7.9% 2.6% 7.0% 7.2% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/12 (8%) 0/16 (0%) 1/21 (5%) 1/30 (3%) 2/27 (7%) |
|FIRST INCIDENCE | 736 (T) 410 736 (T) 708 565 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.454 P=0.330 P=0.633N P=0.596 P=0.536 |
|POLY 3 | P=0.309 P=0.308 P=0.758N P=0.354 P=0.342 |
|POLY 1.5 | P=0.280 P=0.297 P=0.757 P=0.317 P=0.319 |
|POLY 6 | P=0.363 P=0.317 P=0.752N P=0.399 P=0.381 |
|LOGISTIC REGRESSION| P=0.267 P=0.194 P=0.633N P=0.439 P=0.342 |
|COCH-ARM / FISHERS | P=0.262 P=0.244 P=0.705 P=0.237 P=0.303 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Intestine Large, Colon |
| Parasite Metazoan |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 2/50 (4%) 1/50 (2%) 5/50 (10%) 1/60 (2%) |
|POLY-3 ADJUSTED (b)| 0.0% 4.7% 2.3% 12.3% 2.3% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 2/33 (6%) 0/34 (0%) 5/28 (18%) 1/28 (4%) |
|FIRST INCIDENCE | --- 738 (T) 417 738 (T) 738 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.234 P=0.275 P=0.500 P=0.032 * P=0.500 |
|POLY 3 | P=0.256 P=0.245 P=0.512 P=0.029 * P=0.507 |
|POLY 1.5 | P=0.252 P=0.234 P=0.502 P=0.028 * P=0.502 |
|POLY 6 | P=0.263 P=0.257 P=0.520 P=0.027 * P=0.511 |
|LOGISTIC REGRESSION| P=0.269 P=0.275 P=0.250 P=0.032 * P=0.500 |
|COCH-ARM / FISHERS | P=0.285 P=0.204 P=0.455 P=0.017 * P=0.500 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 24
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Intestine Large, Rectum |
| Parasite Metazoan |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/60 (2%) 5/50 (10%) 3/50 (6%) 3/49 (6%) 5/60 (8%) |
|POLY-3 ADJUSTED (b)| 2.6% 13.1% 7.7% 7.0% 12.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 1/21 (5%) 3/30 (10%) 5/27 (19%) |
|FIRST INCIDENCE | 643 507 583 736 (T) 736 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.432 P=0.098 P=0.373 P=0.577 P=0.322 |
|POLY 3 | P=0.251 P=0.101 P=0.312 P=0.348 P=0.124 |
|POLY 1.5 | P=0.221 P=0.095 P=0.299 P=0.315 P=0.112 |
|POLY 6 | P=0.301 P=0.106 P=0.322 P=0.388 P=0.146 |
|LOGISTIC REGRESSION| P=0.212 P=0.062 P=0.295 P=0.392 P=0.178 |
|COCH-ARM / FISHERS | P=0.191 P=0.067 P=0.244 P=0.237 P=0.103 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Intestine Large, Rectum |
| Parasite Metazoan |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 2/60 (3%) 5/50 (10%) 8/50 (16%) 5/50 (10%) 4/60 (7%) |
|POLY-3 ADJUSTED (b)| 4.8% 11.7% 18.3% 12.1% 9.2% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/28 (7%) 5/33 (15%) 7/34 (21%) 2/28 (7%) 1/28 (4%) |
|FIRST INCIDENCE | 738 (T) 738 (T) 451 605 516 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.349 P=0.284 P=0.081 P=0.216 P=0.353 |
|POLY 3 | P=0.437 P=0.230 P=0.055 P=0.216 P=0.362 |
|POLY 1.5 | P=0.421 P=0.210 P=0.046 * P=0.207 P=0.348 |
|POLY 6 | P=0.452 P=0.250 P=0.062 P=0.216 P=0.378 |
|LOGISTIC REGRESSION| P=0.400 P=0.284 P=0.052 P=0.206 P=0.348 |
|COCH-ARM / FISHERS | P=0.421 P=0.151 P=0.024 * P=0.151 P=0.340 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 25
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 2/60 (3%) 0/50 (0%) 0/50 (0%) 1/48 (2%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 5.3% 0.0% 0.0% 2.4% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/12 (17%) 0/16 (0%) 0/21 (0%) 1/30 (3%) 0/27 (0%) |
|FIRST INCIDENCE | 736 (T) --- --- 736 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.079N P=0.175N P=0.124N P=0.200N P=0.085N |
|POLY 3 | P=0.204N P=0.245N P=0.233N P=0.464N P=0.214N |
|POLY 1.5 | P=0.208N P=0.248N P=0.241N P=0.497N P=0.226N |
|POLY 6 | P=0.195N P=0.245N P=0.227N P=0.426N P=0.195N |
|LOGISTIC REGRESSION| P=0.079N (e) (e) P=0.200N (e) |
|COCH-ARM / FISHERS | P=0.196N P=0.295N P=0.295N P=0.584N P=0.248N |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/49 (0%) 0/50 (0%) 1/50 (2%) 1/60 (2%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 2.5% 2.3% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 0/34 (0%) 1/28 (4%) 1/28 (4%) |
|FIRST INCIDENCE | --- --- --- 738 (T) 738 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.126 (e) (e) P=0.500 P=0.500 |
|POLY 3 | P=0.138 (e) (e) P=0.497 P=0.507 |
|POLY 1.5 | P=0.139 (e) (e) P=0.494 P=0.502 |
|POLY 6 | P=0.139 (e) (e) P=0.495 P=0.511 |
|LOGISTIC REGRESSION| (e) (e) (e) P=0.500 P=0.500 |
|COCH-ARM / FISHERS | P=0.157 (e) (e) P=0.455 P=0.500 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 26
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Kidney |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/60 (2%) 4/50 (8%) 1/50 (2%) 1/50 (2%) 3/60 (5%) |
|POLY-3 ADJUSTED (b)| 2.6% 10.8% 2.6% 2.3% 7.1% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 1/16 (6%) 1/21 (5%) 1/31 (3%) 2/27 (7%) |
|FIRST INCIDENCE | 681 507 736 (T) 736 (T) 684 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.468N P=0.198 P=0.704N P=0.616N P=0.508 |
|POLY 3 | P=0.525 P=0.171 P=0.759N P=0.727N P=0.343 |
|POLY 1.5 | P=0.492 P=0.166 P=0.757 P=0.749N P=0.323 |
|POLY 6 | P=0.570 P=0.172 P=0.755N P=0.701N P=0.378 |
|LOGISTIC REGRESSION| P=0.498 P=0.158 P=0.751N P=0.717N P=0.375 |
|COCH-ARM / FISHERS | P=0.444 P=0.130 P=0.705 P=0.705 P=0.309 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Kidney |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/60 (2%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 2.4% 0.0% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/28 (4%) 0/33 (0%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | 738 (T) --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.245N P=0.467N P=0.461N P=0.500N P=0.500N |
|POLY 3 | P=0.259N P=0.493N P=0.492N P=0.503N P=0.493N |
|POLY 1.5 | P=0.251N P=0.503N P=0.501N P=0.506N P=0.498N |
|POLY 6 | P=0.271N P=0.483N P=0.485N P=0.505N P=0.489N |
|LOGISTIC REGRESSION| P=0.245N (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.247N P=0.545N P=0.545N P=0.545N P=0.500N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 27
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Kidney |
| Mineralization |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 8/60 (13%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 9/60 (15%) |
|POLY-3 ADJUSTED (b)| 17.6% 0.0% 0.0% 0.0% 17.8% |
|INT SACRIFICE 1 (c)| 8/10 (80%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 9/10 (90%) |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 0/21 (0%) 0/31 (0%) 0/27 (0%) |
|FIRST INCIDENCE | 184 (I) --- --- --- 184 (I) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.357 P=1.000 P=1.000 P=1.000 P=0.500 |
|POLY 3 | P=0.225 P=0.009N** P=0.007N** P=0.004N** P=0.598 |
|POLY 1.5 | P=0.203 P=0.009N** P=0.008N** P=0.006N** P=0.555 |
|POLY 6 | P=0.258 P=0.010N* P=0.007N** P=0.003N** P=0.549N |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.192 P=0.006N** P=0.006N** P=0.006N** P=0.500 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Kidney |
| Mineralization |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 10/60 (17%) 1/50 (2%) 0/50 (0%) 0/50 (0%) 10/60 (17%) |
|POLY-3 ADJUSTED (b)| 19.6% 2.3% 0.0% 0.0% 19.0% |
|INT SACRIFICE 1 (c)| 10/10 (100%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 10/10 (100%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | 184 (I) 650 --- --- 184 (I) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.451N P=0.520 P=1.000 P=1.000 P=1.000 |
|POLY 3 | P=0.314 P=0.010N* P=0.002N** P=0.003N** P=0.571N |
|POLY 1.5 | P=0.324 P=0.011N* P=0.002N** P=0.003N** P=0.588N |
|POLY 6 | P=0.295 P=0.008N** P=0.002N** P=0.003N** P=0.556N |
|LOGISTIC REGRESSION| P=0.412N P=0.479N (e) (e) P=0.503N |
|COCH-ARM / FISHERS | P=0.336 P=0.010N* P=0.002N** P=0.002N** P=0.596N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 28
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Kidney |
| Nephropathy Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 60/60 (100%) 49/50 (98%) 50/50 (100%) 49/50 (98%) 58/60 (97%) |
|POLY-3 ADJUSTED (b)| 100.0% 99.3% 100.0% 100.0% 99.9% |
|INT SACRIFICE 1 (c)| 10/10 (100%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 9/10 (90%) |
|TERMINAL (d) | 12/12 (100%) 16/16 (100%) 21/21 (100%) 31/31 (100%) 27/27 (100%) |
|FIRST INCIDENCE | 184 (I) 410 360 518 184 (I) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001N** P=0.359N (e) P<0.001N** P<0.001N** |
|POLY 3 | P=0.910 P=0.977N (e) P=1.000N P=1.000N |
|POLY 1.5 | P=0.695N P=0.747N (e) P=1.000N P=0.995N |
|POLY 6 | P=1.000 P=1.000N (e) P=1.000N P=1.000N |
|LOGISTIC REGRESSION| P=0.217N P=0.386N (e) P=0.053N P=0.234N |
|COCH-ARM / FISHERS | P=0.124N P=0.455N (e) P=0.455N P=0.248N |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Kidney |
| Nephropathy Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 47/60 (78%) 46/50 (92%) 44/50 (88%) 48/50 (96%) 52/60 (87%) |
|POLY-3 ADJUSTED (b)| 95.7% 96.2% 92.8% 97.9% 99.8% |
|INT SACRIFICE 1 (c)| 3/10 (30%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 3/10 (30%) |
|TERMINAL (d) | 28/28 (100%) 33/33 (100%) 34/34 (100%) 28/28 (100%) 28/28 (100%) |
|FIRST INCIDENCE | 184 (I) 284 451 417 184 (I) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.105 P=0.267N P=0.126N P=0.279 P=0.335 |
|POLY 3 | P=0.075 P=0.709 P=0.405N P=0.475 P=0.111 |
|POLY 1.5 | P=0.038 * P=0.381 P=0.617N P=0.152 P=0.047 * |
|POLY 6 | P=0.201 P=0.655N P=0.267N P=0.895 P=0.738 |
|LOGISTIC REGRESSION| P=0.029 * P=0.479 P=0.357N P=0.267 P=0.054 |
|COCH-ARM / FISHERS | P=0.142 P=0.042 * P=0.139 P=0.006 ** P=0.168 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 29
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/60 (2%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 2/60 (3%) |
|POLY-3 ADJUSTED (b)| 2.7% 0.0% 0.0% 0.0% 4.8% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 0/21 (0%) 0/31 (0%) 1/27 (4%) |
|FIRST INCIDENCE | 695 --- --- --- 708 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.327 P=0.500N P=0.484N P=0.408N P=0.687 |
|POLY 3 | P=0.228 P=0.509N P=0.498N P=0.471N P=0.537 |
|POLY 1.5 | P=0.222 P=0.510N P=0.504N P=0.490N P=0.518 |
|POLY 6 | P=0.239 P=0.510N P=0.493N P=0.451N P=0.568 |
|LOGISTIC REGRESSION| P=0.262 P=0.508N P=0.495N P=0.474N P=0.580 |
|COCH-ARM / FISHERS | P=0.225 P=0.545N P=0.545N P=0.545N P=0.500 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 1/60 (2%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% 2.3% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | --- --- --- --- 719 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.140 (e) (e) (e) P=0.513 |
|POLY 3 | P=0.151 (e) (e) (e) P=0.507 |
|POLY 1.5 | P=0.152 (e) (e) (e) P=0.503 |
|POLY 6 | P=0.151 (e) (e) (e) P=0.512 |
|LOGISTIC REGRESSION| P=0.148 (e) (e) (e) P=0.510 |
|COCH-ARM / FISHERS | P=0.160 (e) (e) (e) P=0.500 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 30
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Pigmentation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 49/60 (82%) 48/50 (96%) 49/50 (98%) 50/50 (100%) 57/60 (95%) |
|POLY-3 ADJUSTED (b)| 98.3% 98.4% 99.8% 100.0% 95.3% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 10/10 (100%) |
|TERMINAL (d) | 12/12 (100%) 16/16 (100%) 21/21 (100%) 31/31 (100%) 25/27 (93%) |
|FIRST INCIDENCE | 396 410 443 213 184 (I) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.008N** P=0.353N P=0.114N P<0.001N** P=0.064N |
|POLY 3 | P=0.128N P=0.860 P=0.670 P=0.603 P=0.355N |
|POLY 1.5 | P=0.430N P=0.568 P=0.241 P=0.122 P=0.617N |
|POLY 6 | P=0.051N P=0.953 P=0.898 P=0.891 P=0.286N |
|LOGISTIC REGRESSION| P=0.003 ** P=0.679N P=0.740 P=0.142 P=0.014 * |
|COCH-ARM / FISHERS | P=0.006 ** P=0.019 * P=0.005 ** P<0.001 ** P=0.022 * |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Pigmentation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 48/60 (80%) 48/50 (96%) 50/50 (100%) 50/50 (100%) 59/60 (98%) |
|POLY-3 ADJUSTED (b)| 98.1% 99.6% 100.0% 100.0% 100.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 10/10 (100%) |
|TERMINAL (d) | 28/28 (100%) 33/33 (100%) 34/34 (100%) 28/28 (100%) 28/28 (100%) |
|FIRST INCIDENCE | 391 337 399 417 184 (I) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.025 * P=0.179N P=0.246N P=0.408 P=0.099 |
|POLY 3 | P=0.119 P=0.673 P=0.530 P=0.530 P=0.475 |
|POLY 1.5 | P=0.003 ** P=0.226 P=0.061 P=0.061 P=0.039 * |
|POLY 6 | P=0.779 P=0.998 P=0.997 P=0.997 P=0.996 |
|LOGISTIC REGRESSION| P<0.001 ** P=0.366 P=0.162 P=0.197 P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** P=0.011 * P<0.001 ** P<0.001 ** P<0.001 ** |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 31
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Angiectasis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 2/60 (3%) 0/50 (0%) 1/50 (2%) 1/50 (2%) 2/60 (3%) |
|POLY-3 ADJUSTED (b)| 5.3% 0.0% 2.6% 2.3% 4.8% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 1/21 (5%) 1/31 (3%) 2/27 (7%) |
|FIRST INCIDENCE | 647 --- 736 (T) 736 (T) 736 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.542N P=0.241N P=0.422N P=0.312N P=0.481N |
|POLY 3 | P=0.449 P=0.247N P=0.498N P=0.452N P=0.660N |
|POLY 1.5 | P=0.431 P=0.249N P=0.508N P=0.483N P=0.678N |
|POLY 6 | P=0.483 P=0.250N P=0.493N P=0.418N P=0.630N |
|LOGISTIC REGRESSION| P=0.541 P=0.248N P=0.488N P=0.444N P=0.627N |
|COCH-ARM / FISHERS | P=0.439 P=0.295N P=0.569N P=0.569N P=0.691N |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Angiectasis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 0/50 (0%) 1/50 (2%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 2.4% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | --- --- --- 613 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.547 (e) (e) P=0.495 (e) |
|POLY 3 | P=0.500 (e) (e) P=0.500 (e) |
|POLY 1.5 | P=0.500 (e) (e) P=0.495 (e) |
|POLY 6 | P=0.506 (e) (e) P=0.499 (e) |
|LOGISTIC REGRESSION| P=0.552 (e) (e) P=0.447 (e) |
|COCH-ARM / FISHERS | P=0.549 (e) (e) P=0.455 (e) |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 32
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Basophilic Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 18/60 (30%) 14/50 (28%) 20/50 (40%) 16/50 (32%) 32/60 (53%) |
|POLY-3 ADJUSTED (b)| 43.3% 37.9% 49.6% 36.2% 71.6% |
|INT SACRIFICE 1 (c)| 1/10 (10%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 1/10 (10%) |
|TERMINAL (d) | 10/12 (83%) 12/16 (75%) 16/21 (76%) 14/31 (45%) 25/27 (93%) |
|FIRST INCIDENCE | 184 (I) 563 360 544 184 (I) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.468 P=0.091N P=0.197N P=0.002N** P=0.520N |
|POLY 3 | P=0.003 ** P=0.394N P=0.355 P=0.322N P=0.004 ** |
|POLY 1.5 | P=0.002 ** P=0.377N P=0.335 P=0.417N P=0.003 ** |
|POLY 6 | P=0.008 ** P=0.437N P=0.354 P=0.218N P=0.007 ** |
|LOGISTIC REGRESSION| P=0.006 ** P=0.315N P=0.388 P=0.352N P=0.011 * |
|COCH-ARM / FISHERS | P=0.003 ** P=0.493N P=0.185 P=0.492 P=0.008 ** |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Basophilic Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 45/60 (75%) 42/50 (84%) 44/50 (88%) 35/50 (70%) 34/60 (57%) |
|POLY-3 ADJUSTED (b)| 87.1% 92.9% 93.8% 79.0% 76.0% |
|INT SACRIFICE 1 (c)| 4/10 (40%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 27/28 (96%) 33/33 (100%) 34/34 (100%) 25/28 (89%) 27/28 (96%) |
|FIRST INCIDENCE | 184 (I) 522 399 417 516 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.018N* P=0.220N P=0.302N P=0.186N P=0.020N* |
|POLY 3 | P=0.008N** P=0.250 P=0.184 P=0.186N P=0.103N |
|POLY 1.5 | P=0.006N** P=0.273 P=0.189 P=0.163N P=0.073N |
|POLY 6 | P=0.012N* P=0.231 P=0.149 P=0.281N P=0.130N |
|LOGISTIC REGRESSION| P<0.001N** P=0.575N P=0.394 P=0.074N P=0.011N* |
|COCH-ARM / FISHERS | P<0.001N** P=0.179 P=0.068 P=0.354N P=0.027N* |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 33
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Clear Cell Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 6/60 (10%) 2/50 (4%) 7/50 (14%) 5/50 (10%) 9/60 (15%) |
|POLY-3 ADJUSTED (b)| 16.0% 5.5% 18.3% 11.5% 21.5% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 6/12 (50%) 2/16 (13%) 7/21 (33%) 5/31 (16%) 9/27 (33%) |
|FIRST INCIDENCE | 736 (T) 736 (T) 736 (T) 736 (T) 736 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.473N P=0.043N* P=0.287N P=0.031N* P=0.267N |
|POLY 3 | P=0.159 P=0.140N P=0.513 P=0.397N P=0.365 |
|POLY 1.5 | P=0.130 P=0.147N P=0.486 P=0.463N P=0.323 |
|POLY 6 | P=0.217 P=0.137N P=0.535 P=0.322N P=0.440 |
|LOGISTIC REGRESSION| P=0.473N P=0.043N* P=0.287N P=0.031N* P=0.267N |
|COCH-ARM / FISHERS | P=0.123 P=0.203N P=0.361 P=0.622 P=0.291 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Clear Cell Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 11/60 (18%) 10/50 (20%) 8/50 (16%) 3/50 (6%) 16/60 (27%) |
|POLY-3 ADJUSTED (b)| 26.7% 23.4% 18.6% 7.4% 37.3% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 11/28 (39%) 10/33 (30%) 8/34 (24%) 3/28 (11%) 15/28 (54%) |
|FIRST INCIDENCE | 738 (T) 738 (T) 738 (T) 738 (T) 690 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.136 P=0.322N P=0.146N P=0.016N* P=0.155 |
|POLY 3 | P=0.244 P=0.462N P=0.266N P=0.018N* P=0.204 |
|POLY 1.5 | P=0.250 P=0.514N P=0.305N P=0.021N* P=0.188 |
|POLY 6 | P=0.228 P=0.411N P=0.236N P=0.018N* P=0.222 |
|LOGISTIC REGRESSION| P=0.145 P=0.322N P=0.146N P=0.016N* P=0.179 |
|COCH-ARM / FISHERS | P=0.257 P=0.507 P=0.475N P=0.047N* P=0.191 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 34
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Eosinophilic Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 2/60 (3%) 2/50 (4%) 1/50 (2%) 9/50 (18%) 7/60 (12%) |
|POLY-3 ADJUSTED (b)| 5.3% 5.5% 2.6% 20.4% 16.8% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 1/16 (6%) 1/21 (5%) 7/31 (23%) 7/27 (26%) |
|FIRST INCIDENCE | 619 649 736 (T) 605 736 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.081 P=0.672N P=0.393N P=0.243 P=0.356 |
|POLY 3 | P=0.009 ** P=0.681 P=0.498N P=0.045 * P=0.101 |
|POLY 1.5 | P=0.007 ** P=0.676 P=0.508N P=0.031 * P=0.089 |
|POLY 6 | P=0.015 * P=0.680 P=0.493N P=0.068 P=0.124 |
|LOGISTIC REGRESSION| P=0.025 * P=0.678 P=0.491N P=0.058 P=0.173 |
|COCH-ARM / FISHERS | P=0.010 * P=0.619 P=0.569N P=0.012 * P=0.081 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Eosinophilic Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 2/60 (3%) 1/50 (2%) 1/50 (2%) 3/50 (6%) 2/60 (3%) |
|POLY-3 ADJUSTED (b)| 4.8% 2.3% 2.3% 7.3% 4.7% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/28 (4%) 1/33 (3%) 1/34 (3%) 2/28 (7%) 2/28 (7%) |
|FIRST INCIDENCE | 620 738 (T) 738 (T) 634 738 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.381 P=0.454N P=0.452N P=0.491 P=0.690N |
|POLY 3 | P=0.381 P=0.491N P=0.489N P=0.494 P=0.686N |
|POLY 1.5 | P=0.385 P=0.506N P=0.503N P=0.486 P=0.692N |
|POLY 6 | P=0.376 P=0.477N P=0.480N P=0.488 P=0.681N |
|LOGISTIC REGRESSION| P=0.410 P=0.502N P=0.499N P=0.483 P=0.682N |
|COCH-ARM / FISHERS | P=0.425 P=0.569N P=0.569N P=0.414 P=0.691N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 35
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatodiaphragmatic Nodule |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/60 (2%) 7/50 (14%) 6/50 (12%) 8/50 (16%) 5/60 (8%) |
|POLY-3 ADJUSTED (b)| 2.6% 18.6% 15.1% 17.7% 11.9% |
|INT SACRIFICE 1 (c)| 1/10 (10%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 3/16 (19%) 3/21 (14%) 5/31 (16%) 3/27 (11%) |
|FIRST INCIDENCE | 184 (I) 505 521 213 715 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.531N P=0.015 * P=0.039 * P=0.043 * P=0.281 |
|POLY 3 | P=0.279 P=0.025 * P=0.059 P=0.030 * P=0.120 |
|POLY 1.5 | P=0.232 P=0.024 * P=0.052 P=0.020 * P=0.109 |
|POLY 6 | P=0.368 P=0.026 * P=0.066 P=0.045 * P=0.144 |
|LOGISTIC REGRESSION| P=0.221 P=0.016 * P=0.019 * P=0.002 ** P=0.111 |
|COCH-ARM / FISHERS | P=0.214 P=0.016 * P=0.033 * P=0.007 ** P=0.103 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatodiaphragmatic Nodule |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 9/60 (15%) 4/50 (8%) 7/50 (14%) 3/50 (6%) 13/60 (22%) |
|POLY-3 ADJUSTED (b)| 21.0% 9.0% 15.8% 7.3% 27.3% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 3/10 (30%) |
|TERMINAL (d) | 6/28 (21%) 2/33 (6%) 5/34 (15%) 2/28 (7%) 3/28 (11%) |
|FIRST INCIDENCE | 475 337 417 704 184 (I) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.129 P=0.089N P=0.285N P=0.068N P=0.280 |
|POLY 3 | P=0.120 P=0.099N P=0.363N P=0.067N P=0.325 |
|POLY 1.5 | P=0.125 P=0.116N P=0.397N P=0.070N P=0.293 |
|POLY 6 | P=0.113 P=0.087N P=0.342N P=0.073N P=0.357 |
|LOGISTIC REGRESSION| P=0.145 P=0.188N P=0.444N P=0.070N P=0.240 |
|COCH-ARM / FISHERS | P=0.136 P=0.203N P=0.551N P=0.114N P=0.240 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 36
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 29/60 (48%) 16/50 (32%) 22/50 (44%) 22/50 (44%) 39/60 (65%) |
|POLY-3 ADJUSTED (b)| 58.1% 40.0% 52.0% 48.9% 74.3% |
|INT SACRIFICE 1 (c)| 7/10 (70%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 5/10 (50%) |
|TERMINAL (d) | 9/12 (75%) 9/16 (56%) 13/21 (62%) 19/31 (61%) 20/27 (74%) |
|FIRST INCIDENCE | 184 (I) 428 360 544 184 (I) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.441N P=0.080N P=0.156N P=0.003N** P=0.329N |
|POLY 3 | P=0.010 * P=0.057N P=0.346N P=0.236N P=0.052 |
|POLY 1.5 | P=0.006 ** P=0.050N P=0.341N P=0.287N P=0.037 * |
|POLY 6 | P=0.027 * P=0.068N P=0.354N P=0.170N P=0.101 |
|LOGISTIC REGRESSION| P=0.008 ** P=0.107N P=0.511N P=0.517N P=0.047 * |
|COCH-ARM / FISHERS | P=0.008 ** P=0.061N P=0.397N P=0.397N P=0.048 * |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 41/60 (68%) 36/50 (72%) 33/50 (66%) 27/50 (54%) 46/60 (77%) |
|POLY-3 ADJUSTED (b)| 75.0% 78.5% 73.5% 62.9% 82.3% |
|INT SACRIFICE 1 (c)| 10/10 (100%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 10/10 (100%) |
|TERMINAL (d) | 22/28 (79%) 29/33 (88%) 28/34 (82%) 19/28 (68%) 27/28 (96%) |
|FIRST INCIDENCE | 184 (I) 284 399 592 184 (I) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.242 P=0.557 P=0.323N P=0.306N P=0.236 |
|POLY 3 | P=0.334 P=0.429 P=0.523N P=0.127N P=0.226 |
|POLY 1.5 | P=0.331 P=0.410 P=0.501N P=0.105N P=0.204 |
|POLY 6 | P=0.305 P=0.475 P=0.547N P=0.173N P=0.229 |
|LOGISTIC REGRESSION| P=0.338 P=0.412 P=0.485N P=0.095N P=0.202 |
|COCH-ARM / FISHERS | P=0.349 P=0.418 P=0.477N P=0.090N P=0.207 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 37
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Mixed Cell Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/60 (2%) 0/50 (0%) 1/50 (2%) 1/50 (2%) 5/60 (8%) |
|POLY-3 ADJUSTED (b)| 2.7% 0.0% 2.6% 2.3% 12.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/12 (8%) 0/16 (0%) 0/21 (0%) 1/31 (3%) 5/27 (19%) |
|FIRST INCIDENCE | 736 (T) --- 645 736 (T) 736 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.042 * P=0.443N P=0.711N P=0.537N P=0.371 |
|POLY 3 | P=0.014 * P=0.508N P=0.756N P=0.726N P=0.126 |
|POLY 1.5 | P=0.012 * P=0.510N P=0.758 P=0.749N P=0.113 |
|POLY 6 | P=0.017 * P=0.509N P=0.748N P=0.697N P=0.151 |
|LOGISTIC REGRESSION| P=0.023 * (e) P=0.760N P=0.537N P=0.371 |
|COCH-ARM / FISHERS | P=0.012 * P=0.545N P=0.705 P=0.705 P=0.103 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Mixed Cell Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 7/60 (12%) 7/50 (14%) 5/50 (10%) 2/50 (4%) 5/60 (8%) |
|POLY-3 ADJUSTED (b)| 17.0% 16.4% 11.6% 4.9% 11.7% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 7/28 (25%) 7/33 (21%) 5/34 (15%) 2/28 (7%) 4/28 (14%) |
|FIRST INCIDENCE | 738 (T) 738 (T) 738 (T) 738 (T) 714 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.187N P=0.482N P=0.244N P=0.075N P=0.372N |
|POLY 3 | P=0.147N P=0.586N P=0.349N P=0.079N P=0.352N |
|POLY 1.5 | P=0.148N P=0.604 P=0.381N P=0.085N P=0.369N |
|POLY 6 | P=0.151N P=0.549N P=0.325N P=0.080N P=0.334N |
|LOGISTIC REGRESSION| P=0.183N P=0.482N P=0.244N P=0.075N P=0.353N |
|COCH-ARM / FISHERS | P=0.156N P=0.466 P=0.514N P=0.133N P=0.381N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 38
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Pigmentation Bile |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 1/60 (2%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% 2.4% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 0/21 (0%) 0/31 (0%) 0/27 (0%) |
|FIRST INCIDENCE | --- --- --- --- 725 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.202 (e) (e) (e) P=0.624 |
|POLY 3 | P=0.163 (e) (e) (e) P=0.522 |
|POLY 1.5 | P=0.158 (e) (e) (e) P=0.510 |
|POLY 6 | P=0.173 (e) (e) (e) P=0.540 |
|LOGISTIC REGRESSION| P=0.182 (e) (e) (e) P=0.575 |
|COCH-ARM / FISHERS | P=0.160 (e) (e) (e) P=0.500 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Pigmentation Bile |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 2/50 (4%) 1/50 (2%) 0/50 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 4.6% 2.3% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 1/34 (3%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | --- 620 738 (T) --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.304N P=0.271 P=0.539 (e) (e) |
|POLY 3 | P=0.245N P=0.248 P=0.508 (e) (e) |
|POLY 1.5 | P=0.255N P=0.235 P=0.499 (e) (e) |
|POLY 6 | P=0.241N P=0.262 P=0.515 (e) (e) |
|LOGISTIC REGRESSION| P=0.294N P=0.212 P=0.539 (e) (e) |
|COCH-ARM / FISHERS | P=0.295N P=0.204 P=0.455 (e) (e) |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 39
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Pigmentation Hemosiderin |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 0/21 (0%) 0/31 (0%) 0/27 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Pigmentation Hemosiderin |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/60 (2%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 2/60 (3%) |
|POLY-3 ADJUSTED (b)| 2.4% 0.0% 0.0% 0.0% 4.6% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | 704 --- --- --- 472 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.215 P=0.471N P=0.477N P=0.513N P=0.526 |
|POLY 3 | P=0.206 P=0.493N P=0.492N P=0.503N P=0.519 |
|POLY 1.5 | P=0.211 P=0.503N P=0.501N P=0.506N P=0.508 |
|POLY 6 | P=0.200 P=0.485N P=0.486N P=0.506N P=0.529 |
|LOGISTIC REGRESSION| P=0.234 P=0.498N P=0.496N P=0.505N P=0.500 |
|COCH-ARM / FISHERS | P=0.225 P=0.545N P=0.545N P=0.545N P=0.500 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 40
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Thrombosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 0/21 (0%) 0/31 (0%) 0/27 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Thrombosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 2/60 (3%) 1/50 (2%) 0/50 (0%) 0/50 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 4.7% 2.3% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | 391 698 --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.063N P=0.462N P=0.220N P=0.243N P=0.241N |
|POLY 3 | P=0.065N P=0.494N P=0.233N P=0.244N P=0.234N |
|POLY 1.5 | P=0.064N P=0.509N P=0.241N P=0.247N P=0.238N |
|POLY 6 | P=0.068N P=0.479N P=0.227N P=0.248N P=0.231N |
|LOGISTIC REGRESSION| P=0.068N P=0.606N P=0.339N P=0.331N P=0.238N |
|COCH-ARM / FISHERS | P=0.065N P=0.569N P=0.295N P=0.295N P=0.248N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 41
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver: Artery |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 2/60 (3%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% 4.6% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 2/10 (20%) |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 0/21 (0%) 0/31 (0%) 0/27 (0%) |
|FIRST INCIDENCE | --- --- --- --- 184 (I) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.123 (e) (e) (e) P=0.234 |
|POLY 3 | P=0.038 * (e) (e) (e) P=0.273 |
|POLY 1.5 | P=0.036 * (e) (e) (e) P=0.257 |
|POLY 6 | P=0.042 * (e) (e) (e) P=0.296 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.036 * (e) (e) (e) P=0.248 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver: Artery |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 42
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver: Bile Duct |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 49/60 (82%) 47/50 (94%) 46/50 (92%) 48/50 (96%) 48/60 (80%) |
|POLY-3 ADJUSTED (b)| 98.8% 95.4% 94.6% 99.1% 96.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 2/10 (20%) |
|TERMINAL (d) | 12/12 (100%) 16/16 (100%) 20/21 (95%) 31/31 (100%) 27/27 (100%) |
|FIRST INCIDENCE | 396 410 443 518 184 (I) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001N** P=0.313N P=0.062N P<0.001N** P=0.002N** |
|POLY 3 | P=0.494N P=0.323N P=0.247N P=0.916 P=0.378N |
|POLY 1.5 | P=0.390N P=0.571N P=0.447N P=0.474 P=0.354N |
|POLY 6 | P=0.577N P=0.293N P=0.227N P=1.000 P=0.477N |
|LOGISTIC REGRESSION| P=0.382N P=0.592N P=0.274N P=0.409N P=0.477N |
|COCH-ARM / FISHERS | P=0.304N P=0.047 * P=0.097 P=0.019 * P=0.500N |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver: Bile Duct |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 24/60 (40%) 18/50 (36%) 22/50 (44%) 19/50 (38%) 18/60 (30%) |
|POLY-3 ADJUSTED (b)| 55.9% 39.5% 46.8% 44.3% 41.5% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 16/28 (57%) 10/33 (30%) 13/34 (38%) 14/28 (50%) 13/28 (46%) |
|FIRST INCIDENCE | 585 430 535 586 647 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.262N P=0.073N P=0.218N P=0.238N P=0.146N |
|POLY 3 | P=0.224N P=0.086N P=0.255N P=0.187N P=0.122N |
|POLY 1.5 | P=0.205N P=0.139N P=0.368N P=0.226N P=0.141N |
|POLY 6 | P=0.262N P=0.055N P=0.176N P=0.189N P=0.111N |
|LOGISTIC REGRESSION| P=0.163N P=0.138N P=0.398N P=0.218N P=0.085N |
|COCH-ARM / FISHERS | P=0.155N P=0.409N P=0.409 P=0.493N P=0.169N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 43
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver: Centrilobular |
| Hypertrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 3/60 (5%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% 6.7% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 3/10 (30%) |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 0/21 (0%) 0/31 (0%) 0/27 (0%) |
|FIRST INCIDENCE | --- --- --- --- 184 (I) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.056 (e) (e) (e) P=0.111 |
|POLY 3 | P=0.009 ** (e) (e) (e) P=0.153 |
|POLY 1.5 | P=0.009 ** (e) (e) (e) P=0.139 |
|POLY 6 | P=0.011 * (e) (e) (e) P=0.175 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.009 ** (e) (e) (e) P=0.122 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver: Centrilobular |
| Hypertrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 2/60 (3%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% 4.5% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 2/10 (20%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | --- --- --- --- 184 (I) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.123 (e) (e) (e) P=0.234 |
|POLY 3 | P=0.033 * (e) (e) (e) P=0.255 |
|POLY 1.5 | P=0.034 * (e) (e) (e) P=0.248 |
|POLY 6 | P=0.033 * (e) (e) (e) P=0.261 |
|LOGISTIC REGRESSION| P=0.148 (e) (e) (e) P=0.291 |
|COCH-ARM / FISHERS | P=0.036 * (e) (e) (e) P=0.248 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 44
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver: Hepatocyte |
| Degeneration Cystic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 16/60 (27%) 22/50 (44%) 28/50 (56%) 39/50 (78%) 28/60 (47%) |
|POLY-3 ADJUSTED (b)| 39.9% 55.6% 65.2% 81.7% 62.8% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 4/12 (33%) 11/16 (69%) 14/21 (67%) 24/31 (77%) 16/27 (59%) |
|FIRST INCIDENCE | 576 507 527 561 550 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.431N P=0.289 P=0.182 P=0.218 P=0.532 |
|POLY 3 | P=0.005 ** P=0.107 P=0.013 * P<0.001 ** P=0.023 * |
|POLY 1.5 | P=0.002 ** P=0.103 P=0.008 ** P<0.001 ** P=0.015 * |
|POLY 6 | P=0.026 * P=0.097 P=0.018 * P<0.001 ** P=0.049 * |
|LOGISTIC REGRESSION| P=0.010 * P=0.099 P=0.011 * P<0.001 ** P=0.039 * |
|COCH-ARM / FISHERS | P=0.004 ** P=0.044 * P=0.002 ** P<0.001 ** P=0.018 * |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver: Hepatocyte |
| Degeneration Cystic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 0/50 (0%) 1/50 (2%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 2.5% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 0/34 (0%) 1/28 (4%) 0/28 (0%) |
|FIRST INCIDENCE | --- --- --- 738 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.536 (e) (e) P=0.500 (e) |
|POLY 3 | P=0.502 (e) (e) P=0.497 (e) |
|POLY 1.5 | P=0.501 (e) (e) P=0.494 (e) |
|POLY 6 | P=0.510 (e) (e) P=0.495 (e) |
|LOGISTIC REGRESSION| (e) (e) (e) P=0.500 (e) |
|COCH-ARM / FISHERS | P=0.549 (e) (e) P=0.455 (e) |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 45
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver: Hepatocyte |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 3/60 (5%) 0/50 (0%) 2/50 (4%) 1/50 (2%) 2/60 (3%) |
|POLY-3 ADJUSTED (b)| 7.7% 0.0% 5.2% 2.3% 4.7% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 1/21 (5%) 1/31 (3%) 0/27 (0%) |
|FIRST INCIDENCE | 535 --- 521 736 (T) 536 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.394N P=0.139N P=0.451N P=0.188N P=0.423N |
|POLY 3 | P=0.487N P=0.130N P=0.500N P=0.265N P=0.458N |
|POLY 1.5 | P=0.510N P=0.130N P=0.511N P=0.292N P=0.480N |
|POLY 6 | P=0.450N P=0.134N P=0.495N P=0.238N P=0.423N |
|LOGISTIC REGRESSION| P=0.517N P=0.148N P=0.581N P=0.344N P=0.493N |
|COCH-ARM / FISHERS | P=0.518N P=0.159N P=0.586N P=0.381N P=0.500N |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver: Hepatocyte |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 1/50 (2%) 2/50 (4%) 0/50 (0%) 4/60 (7%) |
|POLY-3 ADJUSTED (b)| 0.0% 2.3% 4.7% 0.0% 8.7% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 3/10 (30%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 2/34 (6%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | --- 337 738 (T) --- 184 (I) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.072 P=0.496 P=0.282 (e) P=0.062 |
|POLY 3 | P=0.039 * P=0.511 P=0.246 (e) P=0.075 |
|POLY 1.5 | P=0.039 * P=0.500 P=0.236 (e) P=0.070 |
|POLY 6 | P=0.039 * P=0.521 P=0.255 (e) P=0.080 |
|LOGISTIC REGRESSION| P=0.078 P=0.207 P=0.282 (e) P=0.068 |
|COCH-ARM / FISHERS | P=0.036 * P=0.455 P=0.204 (e) P=0.059 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 46
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver: Hepatocyte |
| Vacuolization Cytoplasmic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 10/60 (17%) 3/50 (6%) 5/50 (10%) 7/50 (14%) 21/60 (35%) |
|POLY-3 ADJUSTED (b)| 24.5% 8.0% 13.0% 15.7% 41.1% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 8/10 (80%) |
|TERMINAL (d) | 1/12 (8%) 0/16 (0%) 4/21 (19%) 6/31 (19%) 10/27 (37%) |
|FIRST INCIDENCE | 396 450 676 213 184 (I) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.026 * P=0.050N P=0.071N P=0.051N P=0.166 |
|POLY 3 | P<0.001 ** P=0.044N* P=0.150N P=0.228N P=0.071 |
|POLY 1.5 | P<0.001 ** P=0.045N* P=0.154N P=0.275N P=0.050 |
|POLY 6 | P=0.003 ** P=0.049N* P=0.159N P=0.188N P=0.102 |
|LOGISTIC REGRESSION| P<0.001 ** P=0.066N P=0.149N P=0.394N P=0.015 * |
|COCH-ARM / FISHERS | P<0.001 ** P=0.074N P=0.232N P=0.455N P=0.018 * |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver: Hepatocyte |
| Vacuolization Cytoplasmic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 7/60 (12%) 2/50 (4%) 1/50 (2%) 3/50 (6%) 9/60 (15%) |
|POLY-3 ADJUSTED (b)| 16.7% 4.5% 2.3% 7.3% 20.9% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 3/28 (11%) 0/33 (0%) 1/34 (3%) 1/28 (4%) 6/28 (21%) |
|FIRST INCIDENCE | 645 337 738 (T) 613 684 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.118 P=0.065N P=0.022N* P=0.188N P=0.417 |
|POLY 3 | P=0.116 P=0.065N P=0.027N* P=0.160N P=0.416 |
|POLY 1.5 | P=0.126 P=0.078N P=0.031N* P=0.168N P=0.400 |
|POLY 6 | P=0.106 P=0.057N P=0.024N* P=0.163N P=0.430 |
|LOGISTIC REGRESSION| P=0.141 P=0.113N P=0.026N* P=0.168N P=0.437 |
|COCH-ARM / FISHERS | P=0.157 P=0.133N P=0.053N P=0.246N P=0.395 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 47
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver: Hepatocyte, Centrilobular |
| Degeneration |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 2/60 (3%) 1/50 (2%) 1/50 (2%) 1/50 (2%) 2/60 (3%) |
|POLY-3 ADJUSTED (b)| 5.3% 2.8% 2.6% 2.3% 4.7% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 0/21 (0%) 0/31 (0%) 0/27 (0%) |
|FIRST INCIDENCE | 617 726 593 621 502 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.518N P=0.488N P=0.466N P=0.387N P=0.588N |
|POLY 3 | P=0.579 P=0.518N P=0.494N P=0.450N P=0.653N |
|POLY 1.5 | P=0.556 P=0.519N P=0.506N P=0.482N P=0.674N |
|POLY 6 | P=0.553N P=0.523N P=0.486N P=0.414N P=0.619N |
|LOGISTIC REGRESSION| P=0.550 P=0.516N P=0.534N P=0.529N P=0.683N |
|COCH-ARM / FISHERS | P=0.547 P=0.569N P=0.569N P=0.569N P=0.691N |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver: Hepatocyte, Centrilobular |
| Degeneration |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 1/50 (2%) 1/50 (2%) 2/60 (3%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 2.3% 2.5% 4.7% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 0/34 (0%) 1/28 (4%) 0/28 (0%) |
|FIRST INCIDENCE | --- --- 733 738 (T) 704 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.057 (e) P=0.545 P=0.500 P=0.257 |
|POLY 3 | P=0.068 (e) P=0.508 P=0.497 P=0.246 |
|POLY 1.5 | P=0.068 (e) P=0.499 P=0.494 P=0.240 |
|POLY 6 | P=0.068 (e) P=0.515 P=0.495 P=0.252 |
|LOGISTIC REGRESSION| P=0.064 (e) P=0.524 P=0.500 P=0.246 |
|COCH-ARM / FISHERS | P=0.075 (e) P=0.455 P=0.455 P=0.248 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 48
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver: Hepatocyte, Centrilobular |
| Hypertrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 7/60 (12%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% 14.4% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 6/10 (60%) |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 0/21 (0%) 0/31 (0%) 0/27 (0%) |
|FIRST INCIDENCE | --- --- --- --- 184 (I) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) P=0.005 ** |
|POLY 3 | P<0.001 ** (e) (e) (e) P=0.021 * |
|POLY 1.5 | P<0.001 ** (e) (e) (e) P=0.016 * |
|POLY 6 | P<0.001 ** (e) (e) (e) P=0.030 * |
|LOGISTIC REGRESSION| P<0.001 ** (e) (e) (e) P=0.003 ** |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) (e) P=0.006 ** |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver: Hepatocyte, Centrilobular |
| Hypertrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 6/60 (10%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% 12.3% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 6/10 (60%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | --- --- --- --- 184 (I) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.004 ** (e) (e) (e) P=0.009 ** |
|POLY 3 | P<0.001 ** (e) (e) (e) P=0.027 * |
|POLY 1.5 | P<0.001 ** (e) (e) (e) P=0.023 * |
|POLY 6 | P<0.001 ** (e) (e) (e) P=0.029 * |
|LOGISTIC REGRESSION| P=0.006 ** (e) (e) (e) P=0.017 * |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) (e) P=0.014 * |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 49
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver: Hepatocyte, Centrilobular |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 2/60 (3%) 4/50 (8%) 1/50 (2%) 2/50 (4%) 2/60 (3%) |
|POLY-3 ADJUSTED (b)| 5.3% 10.7% 2.6% 4.6% 4.7% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/12 (8%) 0/16 (0%) 0/21 (0%) 1/31 (3%) 0/27 (0%) |
|FIRST INCIDENCE | 729 410 640 708 502 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.230N P=0.390 P=0.400N P=0.381N P=0.520N |
|POLY 3 | P=0.328N P=0.333 P=0.491N P=0.638N P=0.649N |
|POLY 1.5 | P=0.359N P=0.322 P=0.505N P=0.675N P=0.672N |
|POLY 6 | P=0.286N P=0.340 P=0.480N P=0.594N P=0.610N |
|LOGISTIC REGRESSION| P=0.388N P=0.302 P=0.486N P=0.515N P=0.671N |
|COCH-ARM / FISHERS | P=0.402N P=0.257 P=0.569N P=0.619 P=0.691N |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver: Hepatocyte, Centrilobular |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 2/60 (3%) 0/50 (0%) 2/50 (4%) 0/50 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 4.7% 0.0% 4.6% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | 391 --- 399 --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.133N P=0.244N P=0.668N P=0.230N P=0.237N |
|POLY 3 | P=0.149N P=0.236N P=0.684N P=0.247N P=0.237N |
|POLY 1.5 | P=0.145N P=0.244N P=0.690 P=0.248N P=0.239N |
|POLY 6 | P=0.157N P=0.229N P=0.675N P=0.252N P=0.235N |
|LOGISTIC REGRESSION| P=0.138N P=0.390N P=0.457 P=0.404N P=0.234N |
|COCH-ARM / FISHERS | P=0.137N P=0.295N P=0.619 P=0.295N P=0.248N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 50
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Lung |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 10/60 (17%) 0/50 (0%) 5/50 (10%) 4/50 (8%) 12/60 (20%) |
|POLY-3 ADJUSTED (b)| 21.8% 0.0% 13.0% 9.2% 25.1% |
|INT SACRIFICE 1 (c)| 7/10 (70%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 6/10 (60%) |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 4/21 (19%) 4/31 (13%) 5/27 (19%) |
|FIRST INCIDENCE | 184 (I) --- 676 736 (T) 184 (I) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.416 P=0.126N P=0.533 P=0.478N P=0.575N |
|POLY 3 | P=0.132 P=0.003N** P=0.220N P=0.085N P=0.449 |
|POLY 1.5 | P=0.108 P=0.002N** P=0.216N P=0.103N P=0.417 |
|POLY 6 | P=0.177 P=0.003N** P=0.226N P=0.064N P=0.514 |
|LOGISTIC REGRESSION| P=0.107 P=0.094N P=0.502 P=0.540 P=0.350 |
|COCH-ARM / FISHERS | P=0.098 P=0.002N** P=0.232N P=0.142N P=0.407 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Lung |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 19/60 (32%) 12/50 (24%) 17/50 (34%) 15/50 (30%) 20/60 (33%) |
|POLY-3 ADJUSTED (b)| 37.9% 27.4% 39.6% 36.1% 41.0% |
|INT SACRIFICE 1 (c)| 7/10 (70%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 5/10 (50%) |
|TERMINAL (d) | 7/28 (25%) 10/33 (30%) 17/34 (50%) 13/28 (46%) 12/28 (43%) |
|FIRST INCIDENCE | 184 (I) 522 738 (T) 605 184 (I) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.309 P=0.447N P=0.362 P=0.315 P=0.521 |
|POLY 3 | P=0.263 P=0.191N P=0.521 P=0.515N P=0.458 |
|POLY 1.5 | P=0.276 P=0.206N P=0.524 P=0.486N P=0.452 |
|POLY 6 | P=0.239 P=0.173N P=0.506 P=0.577N P=0.460 |
|LOGISTIC REGRESSION| P=0.349 P=0.435N P=0.344 P=0.506 P=0.499 |
|COCH-ARM / FISHERS | P=0.341 P=0.250N P=0.477 P=0.508N P=0.500 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 51
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Lung: Alveolar Epithelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/60 (2%) 5/50 (10%) 3/50 (6%) 2/50 (4%) 3/60 (5%) |
|POLY-3 ADJUSTED (b)| 2.7% 13.5% 7.8% 4.6% 7.1% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/12 (8%) 3/16 (19%) 2/21 (10%) 2/31 (7%) 2/27 (7%) |
|FIRST INCIDENCE | 736 (T) 435 593 736 (T) 460 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.314N P=0.153 P=0.459 P=0.672N P=0.538 |
|POLY 3 | P=0.501N P=0.095 P=0.314 P=0.551 P=0.351 |
|POLY 1.5 | P=0.547N P=0.092 P=0.300 P=0.518 P=0.328 |
|POLY 6 | P=0.438N P=0.095 P=0.327 P=0.589 P=0.388 |
|LOGISTIC REGRESSION| P=0.549 P=0.091 P=0.317 P=0.672N P=0.329 |
|COCH-ARM / FISHERS | P=0.507 P=0.067 P=0.244 P=0.431 P=0.309 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Lung: Alveolar Epithelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 5/60 (8%) 2/50 (4%) 5/50 (10%) 3/50 (6%) 5/60 (8%) |
|POLY-3 ADJUSTED (b)| 12.0% 4.7% 11.6% 7.2% 11.7% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 4/28 (14%) 1/33 (3%) 4/34 (12%) 1/28 (4%) 4/28 (14%) |
|FIRST INCIDENCE | 645 731 690 588 684 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.413 P=0.164N P=0.525N P=0.360N P=0.619N |
|POLY 3 | P=0.435 P=0.203N P=0.607N P=0.354N P=0.612N |
|POLY 1.5 | P=0.440 P=0.222N P=0.627 P=0.368N P=0.624N |
|POLY 6 | P=0.425 P=0.187N P=0.587N P=0.354N P=0.600N |
|LOGISTIC REGRESSION| P=0.452 P=0.182N P=0.582N P=0.380N P=0.596N |
|COCH-ARM / FISHERS | P=0.471 P=0.301N P=0.509 P=0.464N P=0.628N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 52
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Lung: Alveolus |
| Infiltration Cellular Histiocyte |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 39/60 (65%) 37/50 (74%) 39/50 (78%) 40/50 (80%) 44/60 (73%) |
|POLY-3 ADJUSTED (b)| 84.1% 81.9% 84.1% 86.4% 90.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 10/12 (83%) 11/16 (69%) 18/21 (86%) 28/31 (90%) 24/27 (89%) |
|FIRST INCIDENCE | 396 435 443 544 360 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.009N** P=0.344N P=0.143N P<0.001N** P=0.034N* |
|POLY 3 | P=0.147 P=0.497N P=0.621 P=0.490 P=0.274 |
|POLY 1.5 | P=0.112 P=0.566N P=0.506 P=0.375 P=0.196 |
|POLY 6 | P=0.223 P=0.474N P=0.616N P=0.524 P=0.406 |
|LOGISTIC REGRESSION| P=0.201 P=0.565N P=0.538 P=0.413N P=0.236 |
|COCH-ARM / FISHERS | P=0.182 P=0.209 P=0.099 P=0.062 P=0.215 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Lung: Alveolus |
| Infiltration Cellular Histiocyte |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 41/60 (68%) 42/50 (84%) 45/50 (90%) 46/50 (92%) 46/60 (77%) |
|POLY-3 ADJUSTED (b)| 88.7% 90.5% 93.8% 96.0% 96.2% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 28/28 (100%) 32/33 (97%) 33/34 (97%) 28/28 (100%) 28/28 (100%) |
|FIRST INCIDENCE | 461 430 399 417 365 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.071 P=0.221N P=0.365N P=0.218 P=0.298 |
|POLY 3 | P=0.041 * P=0.527 P=0.280 P=0.124 P=0.117 |
|POLY 1.5 | P=0.043 * P=0.349 P=0.140 P=0.058 P=0.093 |
|POLY 6 | P=0.046 * P=0.668N P=0.385 P=0.152 P=0.181 |
|LOGISTIC REGRESSION| P=0.045 * P=0.492 P=0.206 P=0.095 P=0.124 |
|COCH-ARM / FISHERS | P=0.188 P=0.045 * P=0.005 ** P=0.002 ** P=0.207 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 53
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Ectasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 2/50 (4%) 1/50 (2%) 1/60 (2%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 5.2% 2.3% 2.4% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 1/21 (5%) 1/31 (3%) 1/27 (4%) |
|FIRST INCIDENCE | --- --- 666 736 (T) 736 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.437 (e) P=0.300 P=0.689 P=0.662 |
|POLY 3 | P=0.308 (e) P=0.242 P=0.529 P=0.521 |
|POLY 1.5 | P=0.282 (e) P=0.233 P=0.510 P=0.510 |
|POLY 6 | P=0.356 (e) P=0.249 P=0.551 P=0.539 |
|LOGISTIC REGRESSION| P=0.343 (e) P=0.245 P=0.689 P=0.662 |
|COCH-ARM / FISHERS | P=0.276 (e) P=0.204 P=0.455 P=0.500 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Ectasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/60 (2%) 0/49 (0%) 0/50 (0%) 0/50 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 2.4% 0.0% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | 698 --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.247N P=0.468N P=0.489N P=0.525N P=0.483N |
|POLY 3 | P=0.258N P=0.498N P=0.493N P=0.503N P=0.494N |
|POLY 1.5 | P=0.250N P=0.507N P=0.501N P=0.506N P=0.498N |
|POLY 6 | P=0.268N P=0.490N P=0.487N P=0.506N P=0.490N |
|LOGISTIC REGRESSION| P=0.242N P=0.506N P=0.500N P=0.507N P=0.494N |
|COCH-ARM / FISHERS | P=0.247N P=0.550N P=0.545N P=0.545N P=0.500N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 54
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Lymph Node, Mediastinal |
| Hyperplasia Lymphoid |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 1/50 (2%) 3/50 (6%) 0/50 (0%) 1/60 (2%) |
|POLY-3 ADJUSTED (b)| 0.0% 2.8% 7.9% 0.0% 2.4% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 1/16 (6%) 3/21 (14%) 0/31 (0%) 1/27 (4%) |
|FIRST INCIDENCE | --- 736 (T) 736 (T) --- 736 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.460N P=0.557 P=0.232 (e) P=0.662 |
|POLY 3 | P=0.589 P=0.492 P=0.120 (e) P=0.521 |
|POLY 1.5 | P=0.552 P=0.490 P=0.115 (e) P=0.510 |
|POLY 6 | P=0.557N P=0.491 P=0.124 (e) P=0.539 |
|LOGISTIC REGRESSION| (e) P=0.557 P=0.232 (e) P=0.662 |
|COCH-ARM / FISHERS | P=0.511 P=0.455 P=0.091 (e) P=0.500 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Lymph Node, Mediastinal |
| Hyperplasia Lymphoid |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 55
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Lymph Node, Mediastinal |
| Pigmentation Hemosiderin |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 25/60 (42%) 19/50 (38%) 23/50 (46%) 36/50 (72%) 24/60 (40%) |
|POLY-3 ADJUSTED (b)| 57.8% 46.6% 55.8% 77.6% 53.4% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 5/12 (42%) 7/16 (44%) 11/21 (52%) 25/31 (81%) 13/27 (48%) |
|FIRST INCIDENCE | 396 507 593 605 502 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.044N* P=0.156N P=0.147N P=0.127N P=0.035N* |
|POLY 3 | P=0.242 P=0.198N P=0.515N P=0.028 * P=0.418N |
|POLY 1.5 | P=0.188 P=0.213N P=0.526N P=0.013 * P=0.468N |
|POLY 6 | P=0.379 P=0.214N P=0.546N P=0.053 P=0.337N |
|LOGISTIC REGRESSION| P=0.399 P=0.228N P=0.418N P=0.060 P=0.364N |
|COCH-ARM / FISHERS | P=0.253 P=0.423N P=0.396 P<0.001 ** P=0.500N |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Lymph Node, Mediastinal |
| Pigmentation Hemosiderin |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 30/60 (50%) 22/50 (44%) 21/50 (42%) 24/50 (48%) 26/60 (43%) |
|POLY-3 ADJUSTED (b)| 65.8% 48.4% 43.9% 52.9% 56.6% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 18/28 (64%) 14/33 (42%) 11/34 (32%) 13/28 (46%) 13/28 (46%) |
|FIRST INCIDENCE | 507 337 399 417 571 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.480N P=0.038N* P=0.032N* P=0.223N P=0.261N |
|POLY 3 | P=0.407N P=0.066N P=0.024N* P=0.141N P=0.241N |
|POLY 1.5 | P=0.406N P=0.093N P=0.043N* P=0.176N P=0.268N |
|POLY 6 | P=0.409N P=0.055N P=0.017N* P=0.146N P=0.217N |
|LOGISTIC REGRESSION| P=0.368N P=0.089N P=0.090N P=0.209N P=0.225N |
|COCH-ARM / FISHERS | P=0.333N P=0.332N P=0.259N P=0.493N P=0.292N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 56
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Lymph Node, Mesenteric |
| Ectasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 1/50 (2%) 2/49 (4%) 6/60 (10%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 2.6% 4.7% 14.2% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 0/21 (0%) 1/30 (3%) 5/27 (19%) |
|FIRST INCIDENCE | --- --- 666 684 614 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.003 ** (e) P=0.500 P=0.385 P=0.084 |
|POLY 3 | P<0.001 ** (e) P=0.505 P=0.268 P=0.022 * |
|POLY 1.5 | P<0.001 ** (e) P=0.497 P=0.245 P=0.019 * |
|POLY 6 | P<0.001 ** (e) P=0.511 P=0.297 P=0.030 * |
|LOGISTIC REGRESSION| P<0.001 ** (e) P=0.493 P=0.281 P=0.031 * |
|COCH-ARM / FISHERS | P<0.001 ** (e) P=0.455 P=0.200 P=0.014 * |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Lymph Node, Mesenteric |
| Ectasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 3/50 (6%) 0/50 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 7.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 3/34 (9%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | --- --- 738 (T) --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.575N (e) P=0.157 (e) (e) |
|POLY 3 | P=0.534N (e) P=0.126 (e) (e) |
|POLY 1.5 | P=0.535N (e) P=0.118 (e) (e) |
|POLY 6 | P=0.540N (e) P=0.133 (e) (e) |
|LOGISTIC REGRESSION| (e) (e) P=0.157 (e) (e) |
|COCH-ARM / FISHERS | P=0.543N (e) P=0.091 (e) (e) |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 57
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Lymph Node, Mesenteric |
| Hyperplasia Lymphoid |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 0/50 (0%) 0/49 (0%) 3/60 (5%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% 7.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 0/21 (0%) 0/30 (0%) 1/27 (4%) |
|FIRST INCIDENCE | --- --- --- --- 360 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.012 * (e) (e) (e) P=0.201 |
|POLY 3 | P=0.009 ** (e) (e) (e) P=0.143 |
|POLY 1.5 | P=0.009 ** (e) (e) (e) P=0.131 |
|POLY 6 | P=0.010 * (e) (e) (e) P=0.165 |
|LOGISTIC REGRESSION| P=0.010 * (e) (e) (e) P=0.122 |
|COCH-ARM / FISHERS | P=0.009 ** (e) (e) (e) P=0.122 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Lymph Node, Mesenteric |
| Hyperplasia Lymphoid |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 58
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/59 (0%) 0/47 (0%) 1/50 (2%) 1/49 (2%) 2/58 (3%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 2.6% 2.3% 4.8% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/9 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 0/21 (0%) 1/31 (3%) 2/27 (7%) |
|FIRST INCIDENCE | --- --- 722 736 (T) 736 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.146 (e) P=0.560 P=0.689 P=0.429 |
|POLY 3 | P=0.085 (e) P=0.507 P=0.530 P=0.263 |
|POLY 1.5 | P=0.077 (e) P=0.500 P=0.511 P=0.249 |
|POLY 6 | P=0.101 (e) P=0.513 P=0.552 P=0.286 |
|LOGISTIC REGRESSION| P=0.124 (e) P=0.527 P=0.689 P=0.429 |
|COCH-ARM / FISHERS | P=0.075 (e) P=0.459 P=0.454 P=0.244 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 2/60 (3%) 2/50 (4%) 0/50 (0%) 0/50 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 4.8% 4.7% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/28 (7%) 1/33 (3%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | 738 (T) 731 --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.046N* P=0.634N P=0.196N P=0.238N P=0.238N |
|POLY 3 | P=0.043N* P=0.681N P=0.228N P=0.239N P=0.229N |
|POLY 1.5 | P=0.044N* P=0.690 P=0.238N P=0.243N P=0.234N |
|POLY 6 | P=0.044N* P=0.663N P=0.221N P=0.242N P=0.224N |
|LOGISTIC REGRESSION| P=0.045N* P=0.635N (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.049N* P=0.619 P=0.295N P=0.295N P=0.248N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 59
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Hyperplasia Cystic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 36/59 (61%) 34/47 (72%) 24/50 (48%) 28/49 (57%) 26/58 (45%) |
|POLY-3 ADJUSTED (b)| 79.4% 79.9% 56.7% 62.6% 60.7% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/9 (0%) |
|TERMINAL (d) | 8/12 (67%) 11/16 (69%) 11/21 (52%) 20/31 (65%) 18/27 (67%) |
|FIRST INCIDENCE | 396 524 443 561 613 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001N** P=0.346N P=0.005N** P<0.001N** P<0.001N** |
|POLY 3 | P=0.009N** P=0.589 P=0.012N* P=0.052N P=0.036N* |
|POLY 1.5 | P=0.010N* P=0.520 P=0.014N* P=0.085N P=0.035N* |
|POLY 6 | P=0.008N** P=0.610 P=0.020N* P=0.043N* P=0.038N* |
|LOGISTIC REGRESSION| P<0.001N** P=0.565 P=0.010N* P=0.023N* P=0.007N** |
|COCH-ARM / FISHERS | P=0.014N* P=0.155 P=0.121N P=0.416N P=0.058N |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Hyperplasia Cystic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 43/60 (72%) 44/50 (88%) 45/50 (90%) 42/50 (84%) 45/60 (75%) |
|POLY-3 ADJUSTED (b)| 87.9% 93.4% 94.3% 86.4% 93.9% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 24/28 (86%) 32/33 (97%) 32/34 (94%) 24/28 (86%) 27/28 (96%) |
|FIRST INCIDENCE | 461 392 451 417 365 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.306 P=0.267N P=0.288N P=0.513N P=0.509 |
|POLY 3 | P=0.387 P=0.275 P=0.216 P=0.533N P=0.240 |
|POLY 1.5 | P=0.413 P=0.216 P=0.163 P=0.616 P=0.265 |
|POLY 6 | P=0.342 P=0.271 P=0.212 P=0.574N P=0.213 |
|LOGISTIC REGRESSION| P=0.457 P=0.358 P=0.343 P=0.537 P=0.408 |
|COCH-ARM / FISHERS | P=0.477N P=0.030 * P=0.014 * P=0.095 P=0.418 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 60
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Mesentery: Fat |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 12/15 (80%) 8/12 (67%) 8/15 (53%) 8/11 (73%) 11/15 (73%) |
|POLY-3 ADJUSTED (b)| 83.4% 73.2% 60.3% 77.5% 87.8% |
|INT SACRIFICE 1 (c)| 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |
|TERMINAL (d) | 3/3 (100%) 0/1 (0%) 3/6 (50%) 5/5 (100%) 9/9 (100%) |
|FIRST INCIDENCE | 593 534 563 610 680 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.012N* P=0.393N P=0.091N P=0.025N* P=0.012N* |
|POLY 3 | P=0.397 P=0.443N P=0.158N P=0.560N P=0.603 |
|POLY 1.5 | P=0.470 P=0.408N P=0.140N P=0.542N P=0.691 |
|POLY 6 | P=0.335 P=0.495N P=0.188N P=0.574N P=0.506 |
|LOGISTIC REGRESSION| P=0.462N P=0.302N P=0.119N P=0.497N P=0.542N |
|COCH-ARM / FISHERS | P=0.519N P=0.364N P=0.123N P=0.509N P=0.500N |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Mesentery: Fat |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 3/8 (38%) 0/1 (0%) 3/5 (60%) 1/5 (20%) 3/6 (50%) |
|POLY-3 ADJUSTED (b)| 42.2% 0.0% 71.7% 25.2% 60.9% |
|INT SACRIFICE 1 (c)| 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |
|TERMINAL (d) | 2/5 (40%) 0/1 (0%) 2/2 (100%) 1/2 (50%) 1/1 (100%) |
|FIRST INCIDENCE | 391 --- 684 738 (T) 600 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.108 P=0.322N P=0.358 P=0.575N P=0.316 |
|POLY 3 | P=0.368 P=0.611N P=0.367 P=0.532N P=0.479 |
|POLY 1.5 | P=0.408 P=0.620N P=0.396 P=0.503N P=0.503 |
|POLY 6 | P=0.299 P=0.599N P=0.308 P=0.591N P=0.441 |
|LOGISTIC REGRESSION| P=0.438 P=0.714N P=0.419 P=0.495N P=0.531 |
|COCH-ARM / FISHERS | P=0.449 P=0.667N P=0.413 P=0.490N P=0.529 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 61
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Nose |
| Fungus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 21/60 (35%) 15/50 (30%) 10/50 (20%) 11/50 (22%) 7/60 (12%) |
|POLY-3 ADJUSTED (b)| 48.9% 36.9% 24.9% 24.2% 16.4% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 6/12 (50%) 3/16 (19%) 5/21 (24%) 6/31 (19%) 2/27 (7%) |
|FIRST INCIDENCE | 396 450 557 544 565 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001N** P=0.157N P=0.004N** P<0.001N** P<0.001N** |
|POLY 3 | P<0.001N** P=0.178N P=0.016N* P=0.012N* P<0.001N** |
|POLY 1.5 | P<0.001N** P=0.192N P=0.019N* P=0.021N* P<0.001N** |
|POLY 6 | P<0.001N** P=0.174N P=0.017N* P=0.006N** P<0.001N** |
|LOGISTIC REGRESSION| P<0.001N** P=0.237N P=0.021N* P=0.028N* P<0.001N** |
|COCH-ARM / FISHERS | P<0.001N** P=0.363N P=0.062N P=0.099N P=0.002N** |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Nose |
| Fungus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 6/60 (10%) 2/50 (4%) 1/50 (2%) 0/50 (0%) 2/60 (3%) |
|POLY-3 ADJUSTED (b)| 13.8% 4.6% 2.3% 0.0% 4.7% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/28 (4%) 0/33 (0%) 1/34 (3%) 0/28 (0%) 1/28 (4%) |
|FIRST INCIDENCE | 461 337 738 (T) --- 652 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.054N P=0.123N P=0.051N P=0.021N* P=0.135N |
|POLY 3 | P=0.057N P=0.128N P=0.056N P=0.018N* P=0.134N |
|POLY 1.5 | P=0.055N P=0.140N P=0.061N P=0.018N* P=0.137N |
|POLY 6 | P=0.062N P=0.119N P=0.055N P=0.020N* P=0.133N |
|LOGISTIC REGRESSION| P=0.053N P=0.242N P=0.085N P=0.028N* P=0.134N |
|COCH-ARM / FISHERS | P=0.052N P=0.203N P=0.091N P=0.023N* P=0.136N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 62
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Nose |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 28/60 (47%) 19/50 (38%) 22/50 (44%) 18/50 (36%) 22/60 (37%) |
|POLY-3 ADJUSTED (b)| 60.1% 46.7% 52.8% 39.5% 49.7% |
|INT SACRIFICE 1 (c)| 3/10 (30%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 1/10 (10%) |
|TERMINAL (d) | 7/12 (58%) 7/16 (44%) 13/21 (62%) 11/31 (36%) 13/27 (48%) |
|FIRST INCIDENCE | 184 (I) 450 521 544 184 (I) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001N** P=0.142N P=0.075N P<0.001N** P=0.004N** |
|POLY 3 | P=0.152N P=0.136N P=0.306N P=0.032N* P=0.207N |
|POLY 1.5 | P=0.183N P=0.133N P=0.306N P=0.053N P=0.210N |
|POLY 6 | P=0.102N P=0.153N P=0.339N P=0.018N* P=0.176N |
|LOGISTIC REGRESSION| P=0.121N P=0.161N P=0.300N P=0.096N P=0.132N |
|COCH-ARM / FISHERS | P=0.162N P=0.236N P=0.465N P=0.175N P=0.177N |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Nose |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 17/60 (28%) 13/50 (26%) 7/50 (14%) 6/50 (12%) 8/60 (13%) |
|POLY-3 ADJUSTED (b)| 35.7% 28.9% 16.1% 14.4% 17.7% |
|INT SACRIFICE 1 (c)| 4/10 (40%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 1/10 (10%) |
|TERMINAL (d) | 7/28 (25%) 8/33 (24%) 6/34 (18%) 4/28 (14%) 3/28 (11%) |
|FIRST INCIDENCE | 184 (I) 337 544 571 11 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.013N* P=0.450N P=0.062N P=0.072N P=0.041N* |
|POLY 3 | P=0.011N* P=0.317N P=0.026N* P=0.017N* P=0.039N* |
|POLY 1.5 | P=0.010N* P=0.352N P=0.030N* P=0.017N* P=0.040N* |
|POLY 6 | P=0.013N* P=0.283N P=0.024N* P=0.020N* P=0.038N* |
|LOGISTIC REGRESSION| P=0.008N** P=0.573N P=0.091N P=0.054N P=0.035N* |
|COCH-ARM / FISHERS | P=0.009N** P=0.478N P=0.056N P=0.030N* P=0.035N* |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 63
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Nose: Nasolacrimal Duct |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 6/60 (10%) 6/50 (12%) 6/50 (12%) 5/50 (10%) 4/60 (7%) |
|POLY-3 ADJUSTED (b)| 15.6% 16.3% 14.9% 11.5% 9.4% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/12 (8%) 2/16 (13%) 2/21 (10%) 4/31 (13%) 1/27 (4%) |
|FIRST INCIDENCE | 617 631 482 712 613 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.053N P=0.544N P=0.469N P=0.118N P=0.157N |
|POLY 3 | P=0.176N P=0.592 P=0.589N P=0.409N P=0.302N |
|POLY 1.5 | P=0.214N P=0.585 P=0.621N P=0.469N P=0.336N |
|POLY 6 | P=0.127N P=0.588 P=0.563N P=0.347N P=0.252N |
|LOGISTIC REGRESSION| P=0.186N P=0.595 P=0.588 P=0.307N P=0.299N |
|COCH-ARM / FISHERS | P=0.248N P=0.486 P=0.486 P=0.622 P=0.372N |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Nose: Nasolacrimal Duct |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 9/60 (15%) 6/50 (12%) 10/50 (20%) 6/50 (12%) 10/60 (17%) |
|POLY-3 ADJUSTED (b)| 21.1% 13.9% 22.6% 14.2% 22.6% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 5/28 (18%) 4/33 (12%) 6/34 (18%) 3/28 (11%) 5/28 (18%) |
|FIRST INCIDENCE | 523 701 600 459 11 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.356 P=0.200N P=0.554N P=0.301N P=0.528 |
|POLY 3 | P=0.409 P=0.279N P=0.535 P=0.289N P=0.537 |
|POLY 1.5 | P=0.413 P=0.307N P=0.493 P=0.304N P=0.521 |
|POLY 6 | P=0.398 P=0.255N P=0.567 P=0.295N P=0.552 |
|LOGISTIC REGRESSION| P=0.409 P=0.275N P=0.498 P=0.344N P=0.512 |
|COCH-ARM / FISHERS | P=0.429 P=0.432N P=0.330 P=0.432N P=0.500 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 64
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Nose: Respiratory Epithelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 24/60 (40%) 16/50 (32%) 17/50 (34%) 13/50 (26%) 11/60 (18%) |
|POLY-3 ADJUSTED (b)| 55.9% 40.1% 41.9% 28.9% 25.7% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 7/12 (58%) 5/16 (31%) 10/21 (48%) 8/31 (26%) 5/27 (19%) |
|FIRST INCIDENCE | 396 507 527 610 565 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001N** P=0.080N P=0.019N* P<0.001N** P<0.001N** |
|POLY 3 | P=0.002N** P=0.100N P=0.132N P=0.007N** P=0.003N** |
|POLY 1.5 | P=0.003N** P=0.109N P=0.145N P=0.014N* P=0.004N** |
|POLY 6 | P<0.001N** P=0.101N P=0.138N P=0.003N** P<0.001N** |
|LOGISTIC REGRESSION| P<0.001N** P=0.115N P=0.113N P=0.011N* P=0.002N** |
|COCH-ARM / FISHERS | P=0.005N** P=0.252N P=0.327N P=0.089N P=0.008N** |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Nose: Respiratory Epithelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 10/60 (17%) 3/50 (6%) 2/50 (4%) 4/50 (8%) 2/60 (3%) |
|POLY-3 ADJUSTED (b)| 23.1% 7.0% 4.7% 9.7% 4.7% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 5/28 (18%) 2/33 (6%) 2/34 (6%) 2/28 (7%) 1/28 (4%) |
|FIRST INCIDENCE | 461 700 738 (T) 586 652 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.019N* P=0.026N* P=0.010N* P=0.086N P=0.018N* |
|POLY 3 | P=0.022N* P=0.034N* P=0.013N* P=0.082N P=0.013N* |
|POLY 1.5 | P=0.021N* P=0.040N* P=0.015N* P=0.086N P=0.014N* |
|POLY 6 | P=0.024N* P=0.030N* P=0.012N* P=0.088N P=0.013N* |
|LOGISTIC REGRESSION| P=0.016N* P=0.044N* P=0.018N* P=0.096N P=0.015N* |
|COCH-ARM / FISHERS | P=0.017N* P=0.074N P=0.032N* P=0.142N P=0.015N* |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 65
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Nose: Respiratory Epithelium |
| Metaplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 12/60 (20%) 9/50 (18%) 8/50 (16%) 7/50 (14%) 5/60 (8%) |
|POLY-3 ADJUSTED (b)| 28.7% 23.0% 20.0% 15.6% 11.7% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/12 (8%) 2/16 (13%) 4/21 (19%) 3/31 (10%) 1/27 (4%) |
|FIRST INCIDENCE | 396 450 527 544 565 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.004N** P=0.338N P=0.144N P=0.032N* P=0.017N* |
|POLY 3 | P=0.024N* P=0.369N P=0.252N P=0.110N P=0.044N* |
|POLY 1.5 | P=0.031N* P=0.369N P=0.261N P=0.143N P=0.049N* |
|POLY 6 | P=0.016N* P=0.387N P=0.259N P=0.082N P=0.035N* |
|LOGISTIC REGRESSION| P=0.031N* P=0.446N P=0.312N P=0.229N P=0.048N* |
|COCH-ARM / FISHERS | P=0.035N* P=0.493N P=0.387N P=0.284N P=0.057N |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Nose: Respiratory Epithelium |
| Metaplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 3/60 (5%) 3/50 (6%) 0/50 (0%) 1/50 (2%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 7.2% 7.0% 0.0% 2.4% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/28 (4%) 2/33 (6%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | 543 700 --- 571 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.032N* P=0.598N P=0.101N P=0.298N P=0.125N |
|POLY 3 | P=0.032N* P=0.651N P=0.114N P=0.310N P=0.115N |
|POLY 1.5 | P=0.032N* P=0.654 P=0.121N P=0.316N P=0.118N |
|POLY 6 | P=0.032N* P=0.632N P=0.110N P=0.313N P=0.112N |
|LOGISTIC REGRESSION| P=0.032N* P=0.662 P=0.130N P=0.357N P=0.118N |
|COCH-ARM / FISHERS | P=0.034N* P=0.570 P=0.159N P=0.381N P=0.122N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 66
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Ovary |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | |
|POLY-3 ADJUSTED (b)| |
|INT SACRIFICE 1 (c)| |
|TERMINAL (d) | |
|FIRST INCIDENCE | |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | |
|POLY 3 | |
|POLY 1.5 | |
|POLY 6 | |
|LOGISTIC REGRESSION| |
|COCH-ARM / FISHERS | |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Ovary |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 5/60 (8%) 6/50 (12%) 4/50 (8%) 8/50 (16%) 9/60 (15%) |
|POLY-3 ADJUSTED (b)| 11.7% 13.8% 9.2% 18.8% 19.8% |
|INT SACRIFICE 1 (c)| 1/10 (10%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 2/10 (20%) |
|TERMINAL (d) | 3/28 (11%) 5/33 (15%) 2/34 (6%) 5/28 (18%) 4/28 (14%) |
|FIRST INCIDENCE | 184 (I) 535 647 444 184 (I) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.118 P=0.456 P=0.551N P=0.194 P=0.214 |
|POLY 3 | P=0.123 P=0.510 P=0.492N P=0.269 P=0.226 |
|POLY 1.5 | P=0.120 P=0.479 P=0.516N P=0.255 P=0.211 |
|POLY 6 | P=0.123 P=0.541 P=0.473N P=0.268 P=0.242 |
|LOGISTIC REGRESSION| P=0.127 P=0.405 P=0.602N P=0.166 P=0.197 |
|COCH-ARM / FISHERS | P=0.126 P=0.373 P=0.615N P=0.173 P=0.197 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 67
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Pancreas: Acinus |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 14/60 (23%) 27/50 (54%) 16/50 (32%) 27/48 (56%) 19/60 (32%) |
|POLY-3 ADJUSTED (b)| 33.9% 62.4% 41.5% 61.2% 43.1% |
|INT SACRIFICE 1 (c)| 2/10 (20%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 4/12 (33%) 7/16 (44%) 13/21 (62%) 18/30 (60%) 12/27 (44%) |
|FIRST INCIDENCE | 184 (I) 428 666 605 502 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.040N* P=0.014 * P=0.479N P=0.390 P=0.323N |
|POLY 3 | P=0.424 P=0.005 ** P=0.315 P=0.007 ** P=0.252 |
|POLY 1.5 | P=0.334 P=0.003 ** P=0.315 P=0.003 ** P=0.208 |
|POLY 6 | P=0.470N P=0.009 ** P=0.285 P=0.022 * P=0.342 |
|LOGISTIC REGRESSION| P=0.458 P=0.002 ** P=0.405 P=0.005 ** P=0.260 |
|COCH-ARM / FISHERS | P=0.345 P<0.001 ** P=0.211 P<0.001 ** P=0.207 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Pancreas: Acinus |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 11/60 (18%) 14/49 (29%) 14/50 (28%) 9/50 (18%) 13/60 (22%) |
|POLY-3 ADJUSTED (b)| 25.4% 32.8% 31.9% 21.6% 29.4% |
|INT SACRIFICE 1 (c)| 1/10 (10%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 6/28 (21%) 12/33 (36%) 12/34 (35%) 6/28 (21%) 8/28 (29%) |
|FIRST INCIDENCE | 184 (I) 535 544 605 472 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.483 P=0.391 P=0.412 P=0.512N P=0.439 |
|POLY 3 | P=0.480N P=0.302 P=0.330 P=0.435N P=0.427 |
|POLY 1.5 | P=0.486N P=0.263 P=0.294 P=0.448N P=0.405 |
|POLY 6 | P=0.485N P=0.340 P=0.355 P=0.448N P=0.449 |
|LOGISTIC REGRESSION| P=0.502N P=0.279 P=0.306 P=0.459N P=0.428 |
|COCH-ARM / FISHERS | P=0.473N P=0.150 P=0.164 P=0.582N P=0.410 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 68
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Pancreas: Acinus |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 2/60 (3%) 0/50 (0%) 0/50 (0%) 0/48 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 5.1% 0.0% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 2/10 (20%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 0/21 (0%) 0/30 (0%) 0/27 (0%) |
|FIRST INCIDENCE | 184 (I) --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.123N P=1.000N P=1.000N P=1.000N P=0.234N |
|POLY 3 | P=0.083N P=0.256N P=0.244N P=0.226N P=0.224N |
|POLY 1.5 | P=0.085N P=0.256N P=0.249N P=0.243N P=0.234N |
|POLY 6 | P=0.083N P=0.259N P=0.240N P=0.206N P=0.207N |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.088N P=0.295N P=0.295N P=0.306N P=0.248N |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Pancreas: Acinus |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/49 (0%) 0/50 (0%) 0/50 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 69
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Parathyroid Gland |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 9/50 (18%) 3/45 (7%) 0/47 (0%) 0/46 (0%) 7/56 (13%) |
|POLY-3 ADJUSTED (b)| 24.7% 9.1% 0.0% 0.0% 17.2% |
|INT SACRIFICE 1 (c)| 0/3 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/9 (0%) |
|TERMINAL (d) | 3/12 (25%) 1/14 (7%) 0/20 (0%) 0/28 (0%) 1/26 (4%) |
|FIRST INCIDENCE | 681 544 --- --- 680 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.112N P=0.059N P<0.001N** P<0.001N** P=0.110N |
|POLY 3 | P=0.231N P=0.076N P<0.001N** P<0.001N** P=0.295N |
|POLY 1.5 | P=0.250N P=0.074N P=0.002N** P<0.001N** P=0.327N |
|POLY 6 | P=0.207N P=0.082N P<0.001N** P<0.001N** P=0.237N |
|LOGISTIC REGRESSION| P=0.233N P=0.084N P=0.002N** P<0.001N** P=0.252N |
|COCH-ARM / FISHERS | P=0.279N P=0.087N P=0.002N** P=0.002N** P=0.302N |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Parathyroid Gland |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/54 (2%) 0/44 (0%) 0/41 (0%) 0/47 (0%) 1/53 (2%) |
|POLY-3 ADJUSTED (b)| 2.6% 0.0% 0.0% 0.0% 2.6% |
|INT SACRIFICE 1 (c)| 0/8 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/8 (0%) |
|TERMINAL (d) | 0/25 (0%) 0/29 (0%) 0/26 (0%) 0/26 (0%) 0/26 (0%) |
|FIRST INCIDENCE | 704 --- --- --- 708 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.561 P=0.471N P=0.477N P=0.513N P=0.743N |
|POLY 3 | P=0.541 P=0.499N P=0.519N P=0.500N P=0.758N |
|POLY 1.5 | P=0.547 P=0.509N P=0.525N P=0.502N P=0.759 |
|POLY 6 | P=0.535 P=0.489N P=0.514N P=0.502N P=0.751N |
|LOGISTIC REGRESSION| P=0.568 P=0.504N P=0.521N P=0.501N P=0.759N |
|COCH-ARM / FISHERS | P=0.571 P=0.551N P=0.568N P=0.535N P=0.748 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 70
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 7/60 (12%) 8/50 (16%) 3/49 (6%) 6/50 (12%) 6/60 (10%) |
|POLY-3 ADJUSTED (b)| 18.2% 21.7% 7.8% 13.5% 14.2% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 3/12 (25%) 6/16 (38%) 1/21 (5%) 3/31 (10%) 4/27 (15%) |
|FIRST INCIDENCE | 579 563 583 614 614 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.062N P=0.587N P=0.080N P=0.117N P=0.137N |
|POLY 3 | P=0.262N P=0.463 P=0.150N P=0.387N P=0.423N |
|POLY 1.5 | P=0.305N P=0.456 P=0.169N P=0.459N P=0.463N |
|POLY 6 | P=0.204N P=0.454 P=0.136N P=0.310N P=0.360N |
|LOGISTIC REGRESSION| P=0.236N P=0.465 P=0.157N P=0.392N P=0.369N |
|COCH-ARM / FISHERS | P=0.345N P=0.350 P=0.256N P=0.593 P=0.500N |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 36/60 (60%) 28/50 (56%) 34/50 (68%) 32/50 (64%) 24/60 (40%) |
|POLY-3 ADJUSTED (b)| 76.3% 61.5% 75.4% 68.9% 52.3% |
|INT SACRIFICE 1 (c)| 1/10 (10%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 23/28 (82%) 19/33 (58%) 27/34 (79%) 19/28 (68%) 13/28 (46%) |
|FIRST INCIDENCE | 184 (I) 392 563 444 472 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.086N P=0.040N* P=0.151N P=0.385N P=0.027N* |
|POLY 3 | P=0.027N* P=0.085N P=0.562N P=0.277N P=0.010N* |
|POLY 1.5 | P=0.030N* P=0.122N P=0.592 P=0.344N P=0.013N* |
|POLY 6 | P=0.026N* P=0.064N P=0.572N P=0.265N P=0.008N** |
|LOGISTIC REGRESSION| P=0.021N* P=0.101N P=0.393N P=0.382N P=0.011N* |
|COCH-ARM / FISHERS | P=0.022N* P=0.409N P=0.252 P=0.409 P=0.022N* |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 71
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 22/60 (37%) 13/50 (26%) 15/49 (31%) 21/50 (42%) 27/60 (45%) |
|POLY-3 ADJUSTED (b)| 53.6% 33.2% 36.0% 45.9% 59.8% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 1/10 (10%) |
|TERMINAL (d) | 6/12 (50%) 3/16 (19%) 8/21 (38%) 13/31 (42%) 17/27 (63%) |
|FIRST INCIDENCE | 593 534 360 544 184 (I) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.337N P=0.054N P=0.029N* P=0.010N* P=0.124N |
|POLY 3 | P=0.075 P=0.044N* P=0.074N P=0.306N P=0.351 |
|POLY 1.5 | P=0.055 P=0.054N P=0.106N P=0.435N P=0.284 |
|POLY 6 | P=0.125 P=0.044N* P=0.061N P=0.205N P=0.454 |
|LOGISTIC REGRESSION| P=0.086 P=0.060N P=0.127N P=0.266N P=0.353 |
|COCH-ARM / FISHERS | P=0.059 P=0.161N P=0.323N P=0.354 P=0.229 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 24/60 (40%) 21/50 (42%) 26/50 (52%) 27/50 (54%) 24/60 (40%) |
|POLY-3 ADJUSTED (b)| 53.7% 47.5% 56.8% 58.7% 52.5% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 16/28 (57%) 15/33 (46%) 19/34 (56%) 16/28 (57%) 13/28 (46%) |
|FIRST INCIDENCE | 475 620 451 417 365 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.299 P=0.172N P=0.442N P=0.356 P=0.524N |
|POLY 3 | P=0.403 P=0.354N P=0.465 P=0.390 P=0.541N |
|POLY 1.5 | P=0.389 P=0.410N P=0.393 P=0.329 P=0.571N |
|POLY 6 | P=0.410 P=0.305N P=0.515 P=0.406 P=0.506N |
|LOGISTIC REGRESSION| P=0.395 P=0.323N P=0.422 P=0.257 P=0.536N |
|COCH-ARM / FISHERS | P=0.449 P=0.493 P=0.143 P=0.101 P=0.574N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 72
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Intermedia |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 1/50 (2%) 3/49 (6%) 1/50 (2%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 2.8% 7.7% 2.3% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 0/21 (0%) 1/31 (3%) 0/27 (0%) |
|FIRST INCIDENCE | --- 708 572 736 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.376N P=0.520 P=0.127 P=0.689 (e) |
|POLY 3 | P=0.410N P=0.493 P=0.124 P=0.529 (e) |
|POLY 1.5 | P=0.447N P=0.490 P=0.115 P=0.510 (e) |
|POLY 6 | P=0.356N P=0.493 P=0.134 P=0.551 (e) |
|LOGISTIC REGRESSION| P=0.477N P=0.493 P=0.086 P=0.689 (e) |
|COCH-ARM / FISHERS | P=0.488N P=0.455 P=0.088 P=0.455 (e) |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Intermedia |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/60 (2%) 2/50 (4%) 0/50 (0%) 1/50 (2%) 2/60 (3%) |
|POLY-3 ADJUSTED (b)| 2.4% 4.7% 0.0% 2.5% 4.7% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 2/33 (6%) 0/34 (0%) 1/28 (4%) 2/28 (7%) |
|FIRST INCIDENCE | 698 738 (T) --- 738 (T) 738 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.398 P=0.557 P=0.489N P=0.747 P=0.510 |
|POLY 3 | P=0.441 P=0.511 P=0.493N P=0.758 P=0.511 |
|POLY 1.5 | P=0.438 P=0.495 P=0.501N P=0.754 P=0.504 |
|POLY 6 | P=0.441 P=0.526 P=0.487N P=0.755 P=0.517 |
|LOGISTIC REGRESSION| P=0.417 P=0.531 P=0.500N P=0.757 P=0.520 |
|COCH-ARM / FISHERS | P=0.439 P=0.431 P=0.545N P=0.705 P=0.500 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 73
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Preputial Gland |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 7/60 (12%) 7/50 (14%) 7/50 (14%) 4/50 (8%) 8/59 (14%) |
|POLY-3 ADJUSTED (b)| 18.1% 18.5% 17.9% 9.1% 19.3% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 5/12 (42%) 3/16 (19%) 4/21 (19%) 3/31 (10%) 6/27 (22%) |
|FIRST INCIDENCE | 396 435 572 660 613 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.123N P=0.497N P=0.337N P=0.022N* P=0.211N |
|POLY 3 | P=0.444N P=0.603 P=0.605N P=0.192N P=0.560 |
|POLY 1.5 | P=0.495N P=0.584 P=0.598 P=0.238N P=0.518 |
|POLY 6 | P=0.367N P=0.617 P=0.580N P=0.145N P=0.595N |
|LOGISTIC REGRESSION| P=0.457N P=0.563 P=0.608N P=0.193N P=0.598 |
|COCH-ARM / FISHERS | P=0.541 P=0.466 P=0.466 P=0.378N P=0.486 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Preputial Gland |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | |
|POLY-3 ADJUSTED (b)| |
|INT SACRIFICE 1 (c)| |
|TERMINAL (d) | |
|FIRST INCIDENCE | |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | |
|POLY 3 | |
|POLY 1.5 | |
|POLY 6 | |
|LOGISTIC REGRESSION| |
|COCH-ARM / FISHERS | |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 74
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Preputial Gland |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 52/60 (87%) 40/50 (80%) 47/50 (94%) 47/50 (94%) 54/59 (92%) |
|POLY-3 ADJUSTED (b)| 93.5% 86.0% 96.8% 97.0% 95.5% |
|INT SACRIFICE 1 (c)| 10/10 (100%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 10/10 (100%) |
|TERMINAL (d) | 12/12 (100%) 13/16 (81%) 20/21 (95%) 30/31 (97%) 26/27 (96%) |
|FIRST INCIDENCE | 184 (I) 410 443 518 184 (I) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001N** P=0.306N P=0.279N P<0.001N** P=0.004N** |
|POLY 3 | P=0.104 P=0.139N P=0.337 P=0.319 P=0.469 |
|POLY 1.5 | P=0.068 P=0.184N P=0.222 P=0.197 P=0.344 |
|POLY 6 | P=0.211 P=0.087N P=0.638 P=0.637 P=0.731 |
|LOGISTIC REGRESSION| P=0.081 P=0.204N P=0.262 P=0.350 P=0.297 |
|COCH-ARM / FISHERS | P=0.074 P=0.247N P=0.170 P=0.170 P=0.290 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Preputial Gland |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | |
|POLY-3 ADJUSTED (b)| |
|INT SACRIFICE 1 (c)| |
|TERMINAL (d) | |
|FIRST INCIDENCE | |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | |
|POLY 3 | |
|POLY 1.5 | |
|POLY 6 | |
|LOGISTIC REGRESSION| |
|COCH-ARM / FISHERS | |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 75
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Preputial Gland: Duct |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 2/60 (3%) 0/50 (0%) 2/50 (4%) 0/50 (0%) 0/59 (0%) |
|POLY-3 ADJUSTED (b)| 5.2% 0.0% 5.2% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 1/21 (5%) 0/31 (0%) 0/27 (0%) |
|FIRST INCIDENCE | 561 --- 666 --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.072N P=0.238N P=0.608N P=0.152N P=0.172N |
|POLY 3 | P=0.119N P=0.248N P=0.692N P=0.210N P=0.221N |
|POLY 1.5 | P=0.130N P=0.249N P=0.687 P=0.228N P=0.232N |
|POLY 6 | P=0.105N P=0.250N P=0.685N P=0.191N P=0.205N |
|LOGISTIC REGRESSION| P=0.124N P=0.257N P=0.690 P=0.251N P=0.232N |
|COCH-ARM / FISHERS | P=0.139N P=0.295N P=0.619 P=0.295N P=0.252N |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Preputial Gland: Duct |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | |
|POLY-3 ADJUSTED (b)| |
|INT SACRIFICE 1 (c)| |
|TERMINAL (d) | |
|FIRST INCIDENCE | |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | |
|POLY 3 | |
|POLY 1.5 | |
|POLY 6 | |
|LOGISTIC REGRESSION| |
|COCH-ARM / FISHERS | |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 76
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Prostate |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 43/60 (72%) 34/50 (68%) 32/50 (64%) 26/49 (53%) 44/60 (73%) |
|POLY-3 ADJUSTED (b)| 81.0% 73.1% 67.9% 54.9% 82.3% |
|INT SACRIFICE 1 (c)| 5/10 (50%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 7/10 (70%) |
|TERMINAL (d) | 8/12 (67%) 10/16 (63%) 10/21 (48%) 15/30 (50%) 24/27 (89%) |
|FIRST INCIDENCE | 184 (I) 410 360 213 184 (I) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.009N** P=0.260N P=0.072N P<0.001N** P=0.019N* |
|POLY 3 | P=0.455N P=0.227N P=0.088N P=0.003N** P=0.537 |
|POLY 1.5 | P=0.468N P=0.230N P=0.101N P=0.005N** P=0.545 |
|POLY 6 | P=0.432N P=0.257N P=0.090N P=0.002N** P=0.527 |
|LOGISTIC REGRESSION| P=0.502N P=0.393N P=0.253N P=0.043N* P=0.523 |
|COCH-ARM / FISHERS | P=0.493N P=0.416N P=0.256N P=0.036N* P=0.500 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Prostate |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | |
|POLY-3 ADJUSTED (b)| |
|INT SACRIFICE 1 (c)| |
|TERMINAL (d) | |
|FIRST INCIDENCE | |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | |
|POLY 3 | |
|POLY 1.5 | |
|POLY 6 | |
|LOGISTIC REGRESSION| |
|COCH-ARM / FISHERS | |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 77
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Cyst Epithelial Inclusion |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 1/50 (2%) 0/50 (0%) 2/50 (4%) 2/60 (3%) |
|POLY-3 ADJUSTED (b)| 0.0% 2.8% 0.0% 4.6% 4.8% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 1/16 (6%) 0/21 (0%) 1/31 (3%) 2/27 (7%) |
|FIRST INCIDENCE | --- 736 (T) --- 707 736 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.224 P=0.557 (e) P=0.428 P=0.429 |
|POLY 3 | P=0.119 P=0.492 (e) P=0.273 P=0.261 |
|POLY 1.5 | P=0.109 P=0.490 (e) P=0.250 P=0.249 |
|POLY 6 | P=0.140 P=0.491 (e) P=0.303 P=0.283 |
|LOGISTIC REGRESSION| P=0.177 P=0.557 (e) P=0.318 P=0.429 |
|COCH-ARM / FISHERS | P=0.109 P=0.455 (e) P=0.204 P=0.248 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Cyst Epithelial Inclusion |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 1/60 (2%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% 2.3% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) 1/28 (4%) |
|FIRST INCIDENCE | --- --- --- --- 738 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.134 (e) (e) (e) P=0.500 |
|POLY 3 | P=0.151 (e) (e) (e) P=0.507 |
|POLY 1.5 | P=0.152 (e) (e) (e) P=0.502 |
|POLY 6 | P=0.151 (e) (e) (e) P=0.511 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) P=0.500 |
|COCH-ARM / FISHERS | P=0.160 (e) (e) (e) P=0.500 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 78
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin: Epidermis |
| Hyperkeratosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 1/50 (2%) 3/50 (6%) 3/50 (6%) 4/60 (7%) |
|POLY-3 ADJUSTED (b)| 0.0% 2.8% 7.9% 6.9% 9.6% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 3/21 (14%) 3/31 (10%) 3/27 (11%) |
|FIRST INCIDENCE | --- 726 736 (T) 736 (T) 715 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.135 P=0.525 P=0.232 P=0.328 P=0.186 |
|POLY 3 | P=0.046 * P=0.492 P=0.120 P=0.149 P=0.075 |
|POLY 1.5 | P=0.038 * P=0.490 P=0.115 P=0.129 P=0.067 |
|POLY 6 | P=0.065 P=0.492 P=0.124 P=0.175 P=0.089 |
|LOGISTIC REGRESSION| P=0.097 P=0.506 P=0.232 P=0.328 P=0.132 |
|COCH-ARM / FISHERS | P=0.035 * P=0.455 P=0.091 P=0.091 P=0.059 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin: Epidermis |
| Hyperkeratosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 79
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin: Epidermis |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/60 (2%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 2.6% 0.0% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 0/21 (0%) 0/31 (0%) 0/27 (0%) |
|FIRST INCIDENCE | 663 --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.210N P=0.521N P=0.507N P=0.448N P=0.448N |
|POLY 3 | P=0.245N P=0.509N P=0.498N P=0.472N P=0.480N |
|POLY 1.5 | P=0.244N P=0.511N P=0.504N P=0.490N P=0.490N |
|POLY 6 | P=0.250N P=0.512N P=0.494N P=0.452N P=0.463N |
|LOGISTIC REGRESSION| P=0.238N P=0.514N P=0.509N P=0.508N P=0.487N |
|COCH-ARM / FISHERS | P=0.247N P=0.545N P=0.545N P=0.545N P=0.500N |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin: Epidermis |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/60 (2%) 0/50 (0%) 2/50 (4%) 0/50 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 2.4% 0.0% 4.6% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/28 (4%) 0/33 (0%) 1/34 (3%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | 738 (T) --- 600 --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.299N P=0.467N P=0.553 P=0.500N P=0.500N |
|POLY 3 | P=0.301N P=0.493N P=0.518 P=0.503N P=0.493N |
|POLY 1.5 | P=0.297N P=0.503N P=0.501 P=0.506N P=0.498N |
|POLY 6 | P=0.310N P=0.483N P=0.532 P=0.505N P=0.489N |
|LOGISTIC REGRESSION| P=0.294N (e) P=0.494 (e) (e) |
|COCH-ARM / FISHERS | P=0.295N P=0.545N P=0.431 P=0.545N P=0.500N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 80
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Spleen |
| Fibrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 5/60 (8%) 3/50 (6%) 3/50 (6%) 1/50 (2%) 6/60 (10%) |
|POLY-3 ADJUSTED (b)| 13.2% 8.3% 7.8% 2.3% 14.4% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 4/12 (33%) 2/16 (13%) 2/21 (10%) 1/31 (3%) 6/27 (22%) |
|FIRST INCIDENCE | 603 723 645 736 (T) 736 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.259N P=0.231N P=0.158N P=0.007N** P=0.244N |
|POLY 3 | P=0.511 P=0.381N P=0.347N P=0.073N P=0.567 |
|POLY 1.5 | P=0.477 P=0.386N P=0.366N P=0.091N P=0.532 |
|POLY 6 | P=0.548N P=0.386N P=0.332N P=0.057N P=0.625 |
|LOGISTIC REGRESSION| P=0.447N P=0.361N P=0.324N P=0.046N* P=0.515N |
|COCH-ARM / FISHERS | P=0.446 P=0.464N P=0.464N P=0.151N P=0.500 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Spleen |
| Fibrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/60 (2%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 2.4% 0.0% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | 696 --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.250N P=0.473N P=0.494N P=0.531N P=0.489N |
|POLY 3 | P=0.258N P=0.494N P=0.493N P=0.503N P=0.494N |
|POLY 1.5 | P=0.251N P=0.503N P=0.501N P=0.506N P=0.498N |
|POLY 6 | P=0.269N P=0.485N P=0.487N P=0.506N P=0.490N |
|LOGISTIC REGRESSION| P=0.243N P=0.502N P=0.501N P=0.507N P=0.494N |
|COCH-ARM / FISHERS | P=0.247N P=0.545N P=0.545N P=0.545N P=0.500N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 81
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Spleen |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 4/60 (7%) 0/50 (0%) 1/50 (2%) 0/50 (0%) 3/60 (5%) |
|POLY-3 ADJUSTED (b)| 10.3% 0.0% 2.6% 0.0% 7.1% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/12 (8%) 0/16 (0%) 0/21 (0%) 0/31 (0%) 0/27 (0%) |
|FIRST INCIDENCE | 396 --- 593 --- 614 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.393N P=0.058N P=0.138N P=0.023N* P=0.327N |
|POLY 3 | P=0.493N P=0.068N P=0.178N P=0.047N* P=0.451N |
|POLY 1.5 | P=0.509N P=0.068N P=0.187N P=0.056N P=0.478N |
|POLY 6 | P=0.474N P=0.070N P=0.171N P=0.039N* P=0.404N |
|LOGISTIC REGRESSION| P=0.517N P=0.081N P=0.233N P=0.081N P=0.480N |
|COCH-ARM / FISHERS | P=0.518N P=0.084N P=0.244N P=0.084N P=0.500N |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Spleen |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 9/60 (15%) 12/50 (24%) 6/50 (12%) 10/50 (20%) 7/60 (12%) |
|POLY-3 ADJUSTED (b)| 21.0% 27.6% 13.6% 23.3% 15.5% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 5/28 (18%) 10/33 (30%) 3/34 (9%) 6/28 (21%) 0/28 (0%) |
|FIRST INCIDENCE | 391 535 399 417 365 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.300N P=0.450 P=0.200N P=0.499 P=0.378N |
|POLY 3 | P=0.214N P=0.324 P=0.263N P=0.505 P=0.343N |
|POLY 1.5 | P=0.230N P=0.287 P=0.293N P=0.481 P=0.370N |
|POLY 6 | P=0.200N P=0.362 P=0.243N P=0.502 P=0.313N |
|LOGISTIC REGRESSION| P=0.245N P=0.309 P=0.339N P=0.412 P=0.388N |
|COCH-ARM / FISHERS | P=0.237N P=0.170 P=0.432N P=0.330 P=0.395N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 82
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Spleen |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 2/60 (3%) 0/50 (0%) 2/50 (4%) 2/50 (4%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 5.3% 0.0% 5.2% 4.6% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 0/21 (0%) 1/31 (3%) 0/27 (0%) |
|FIRST INCIDENCE | 690 --- 617 709 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.163N P=0.229N P=0.631N P=0.435N P=0.139N |
|POLY 3 | P=0.278N P=0.246N P=0.686N P=0.640N P=0.215N |
|POLY 1.5 | P=0.299N P=0.248N P=0.690 P=0.675N P=0.226N |
|POLY 6 | P=0.241N P=0.247N P=0.675N P=0.598N P=0.197N |
|LOGISTIC REGRESSION| P=0.243N P=0.243N P=0.692N P=0.581N P=0.187N |
|COCH-ARM / FISHERS | P=0.295N P=0.295N P=0.619 P=0.619 P=0.248N |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Spleen |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/60 (2%) 0/50 (0%) 0/50 (0%) 1/50 (2%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 2.4% 0.0% 0.0% 2.4% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | 573 --- --- 634 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.425N P=0.495N P=0.491N P=0.759N P=0.486N |
|POLY 3 | P=0.461N P=0.495N P=0.494N P=0.758 P=0.496N |
|POLY 1.5 | P=0.455N P=0.504N P=0.502N P=0.754 P=0.499N |
|POLY 6 | P=0.468N P=0.488N P=0.489N P=0.755 P=0.493N |
|LOGISTIC REGRESSION| P=0.426N P=0.580N P=0.591N P=0.707 P=0.500N |
|COCH-ARM / FISHERS | P=0.430N P=0.545N P=0.545N P=0.705 P=0.500N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 83
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 10/60 (17%) 4/50 (8%) 3/50 (6%) 2/50 (4%) 2/60 (3%) |
|POLY-3 ADJUSTED (b)| 25.5% 10.7% 7.6% 4.5% 4.7% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 1/16 (6%) 0/21 (0%) 0/31 (0%) 0/27 (0%) |
|FIRST INCIDENCE | 579 544 360 561 265 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001N** P=0.084N P=0.028N* P=0.002N** P=0.004N** |
|POLY 3 | P=0.004N** P=0.080N P=0.029N* P=0.007N** P=0.008N** |
|POLY 1.5 | P=0.005N** P=0.085N P=0.035N* P=0.011N* P=0.010N* |
|POLY 6 | P=0.002N** P=0.081N P=0.026N* P=0.004N** P=0.005N** |
|LOGISTIC REGRESSION| P=0.006N** P=0.090N P=0.046N* P=0.011N* P=0.012N* |
|COCH-ARM / FISHERS | P=0.006N** P=0.142N P=0.074N P=0.032N* P=0.015N* |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/60 (2%) 0/50 (0%) 3/50 (6%) 1/50 (2%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 2.4% 0.0% 6.8% 2.4% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | 731 --- 451 684 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.399N P=0.468N P=0.335 P=0.750 P=0.507N |
|POLY 3 | P=0.408N P=0.493N P=0.331 P=0.759 P=0.493N |
|POLY 1.5 | P=0.406N P=0.503N P=0.310 P=0.755 P=0.498N |
|POLY 6 | P=0.414N P=0.484N P=0.350 P=0.758 P=0.489N |
|LOGISTIC REGRESSION| P=0.388N P=0.475N P=0.212 P=0.757 P=0.489N |
|COCH-ARM / FISHERS | P=0.390N P=0.545N P=0.244 P=0.705 P=0.500N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 84
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Stomach, Forestomach: Epithelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 8/60 (13%) 8/50 (16%) 4/50 (8%) 3/50 (6%) 4/60 (7%) |
|POLY-3 ADJUSTED (b)| 20.4% 21.1% 9.9% 6.8% 9.2% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 2/16 (13%) 0/21 (0%) 0/31 (0%) 1/27 (4%) |
|FIRST INCIDENCE | 579 544 360 561 265 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.014N* P=0.579N P=0.156N P=0.022N* P=0.074N |
|POLY 3 | P=0.031N* P=0.583 P=0.158N P=0.064N P=0.125N |
|POLY 1.5 | P=0.040N* P=0.570 P=0.178N P=0.086N P=0.147N |
|POLY 6 | P=0.022N* P=0.584 P=0.147N P=0.047N* P=0.100N |
|LOGISTIC REGRESSION| P=0.057N P=0.561 P=0.241N P=0.087N P=0.169N |
|COCH-ARM / FISHERS | P=0.056N P=0.449 P=0.281N P=0.170N P=0.181N |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Stomach, Forestomach: Epithelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 3/60 (5%) 1/50 (2%) 3/50 (6%) 3/50 (6%) 4/60 (7%) |
|POLY-3 ADJUSTED (b)| 7.1% 2.3% 6.8% 7.2% 9.2% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) 1/28 (4%) |
|FIRST INCIDENCE | 543 620 451 605 472 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.257 P=0.280N P=0.625N P=0.644 P=0.520 |
|POLY 3 | P=0.244 P=0.295N P=0.637N P=0.660 P=0.521 |
|POLY 1.5 | P=0.248 P=0.311N P=0.660N P=0.650 P=0.508 |
|POLY 6 | P=0.238 P=0.281N P=0.619N P=0.659 P=0.532 |
|LOGISTIC REGRESSION| P=0.280 P=0.355N P=0.550 P=0.602 P=0.505 |
|COCH-ARM / FISHERS | P=0.276 P=0.381N P=0.570 P=0.570 P=0.500 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 85
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Stomach, Forestomach: Epithelium |
| Hyperplasia Basal Cell |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 2/50 (4%) 0/50 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 5.2% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 2/21 (10%) 0/31 (0%) 0/27 (0%) |
|FIRST INCIDENCE | --- --- 736 (T) --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.441N (e) P=0.367 (e) (e) |
|POLY 3 | P=0.522N (e) P=0.240 (e) (e) |
|POLY 1.5 | P=0.549N (e) P=0.233 (e) (e) |
|POLY 6 | P=0.487N (e) P=0.246 (e) (e) |
|LOGISTIC REGRESSION| (e) (e) P=0.367 (e) (e) |
|COCH-ARM / FISHERS | P=0.587N (e) P=0.204 (e) (e) |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Stomach, Forestomach: Epithelium |
| Hyperplasia Basal Cell |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 86
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Stomach, Forestomach: Epithelium |
| Ulcer |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 8/60 (13%) 3/50 (6%) 4/50 (8%) 1/50 (2%) 1/60 (2%) |
|POLY-3 ADJUSTED (b)| 20.7% 8.1% 10.0% 2.3% 2.4% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 1/16 (6%) 0/21 (0%) 0/31 (0%) 0/27 (0%) |
|FIRST INCIDENCE | 600 544 527 561 715 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001N** P=0.101N P=0.138N P=0.003N** P=0.003N** |
|POLY 3 | P=0.004N** P=0.105N P=0.155N P=0.009N** P=0.010N* |
|POLY 1.5 | P=0.005N** P=0.111N P=0.177N P=0.013N* P=0.013N* |
|POLY 6 | P=0.002N** P=0.104N P=0.137N P=0.005N** P=0.007N** |
|LOGISTIC REGRESSION| P=0.005N** P=0.115N P=0.196N P=0.011N* P=0.009N** |
|COCH-ARM / FISHERS | P=0.006N** P=0.170N P=0.281N P=0.031N* P=0.016N* |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Stomach, Forestomach: Epithelium |
| Ulcer |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 2/60 (3%) 0/50 (0%) 3/50 (6%) 1/50 (2%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 4.8% 0.0% 6.8% 2.4% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | 475 --- 451 684 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.225N P=0.227N P=0.525 P=0.513N P=0.246N |
|POLY 3 | P=0.245N P=0.233N P=0.525 P=0.509N P=0.233N |
|POLY 1.5 | P=0.240N P=0.242N P=0.502 P=0.513N P=0.237N |
|POLY 6 | P=0.254N P=0.225N P=0.544 P=0.514N P=0.230N |
|LOGISTIC REGRESSION| P=0.219N P=0.294N P=0.336 P=0.571N P=0.238N |
|COCH-ARM / FISHERS | P=0.221N P=0.295N P=0.414 P=0.569N P=0.248N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 87
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Stomach, Glandular |
| Mineralization |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/60 (2%) 0/50 (0%) 0/50 (0%) 1/50 (2%) 2/60 (3%) |
|POLY-3 ADJUSTED (b)| 2.7% 0.0% 0.0% 2.3% 4.8% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/16 (0%) 0/21 (0%) 1/31 (3%) 1/27 (4%) |
|FIRST INCIDENCE | 715 --- --- 736 (T) 684 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.305 P=0.490N P=0.462N P=0.591N P=0.670 |
|POLY 3 | P=0.191 P=0.508N P=0.497N P=0.726N P=0.538 |
|POLY 1.5 | P=0.182 P=0.510N P=0.504N P=0.749N P=0.518 |
|POLY 6 | P=0.210 P=0.510N P=0.493N P=0.699N P=0.570 |
|LOGISTIC REGRESSION| P=0.240 P=0.504N P=0.483N P=0.666N P=0.577 |
|COCH-ARM / FISHERS | P=0.191 P=0.545N P=0.545N P=0.705 P=0.500 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Stomach, Glandular |
| Mineralization |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 0/50 (0%) 0/50 (0%) 0/50 (0%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 88
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Stomach, Glandular: Epithelium |
| Erosion |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 2/60 (3%) 1/50 (2%) 0/50 (0%) 2/50 (4%) 1/60 (2%) |
|POLY-3 ADJUSTED (b)| 5.3% 2.7% 0.0% 4.5% 2.4% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/12 (8%) 0/16 (0%) 0/21 (0%) 1/31 (3%) 0/27 (0%) |
|FIRST INCIDENCE | 603 614 --- 518 708 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.341N P=0.480N P=0.180N P=0.498N P=0.343N |
|POLY 3 | P=0.456N P=0.514N P=0.235N P=0.638N P=0.466N |
|POLY 1.5 | P=0.471N P=0.517N P=0.242N P=0.674N P=0.484N |
|POLY 6 | P=0.429N P=0.515N P=0.231N P=0.596N P=0.437N |
|LOGISTIC REGRESSION| P=0.462N P=0.531N P=0.242N P=0.665 P=0.466N |
|COCH-ARM / FISHERS | P=0.469N P=0.569N P=0.295N P=0.619 P=0.500N |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Stomach, Glandular: Epithelium |
| Erosion |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 1/60 (2%) 2/50 (4%) 1/50 (2%) 2/50 (4%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 2.4% 4.6% 2.3% 4.8% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 0/33 (0%) 0/34 (0%) 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE | 696 620 733 572 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.303N P=0.542 P=0.733N P=0.480 P=0.489N |
|POLY 3 | P=0.294N P=0.516 P=0.752N P=0.502 P=0.494N |
|POLY 1.5 | P=0.298N P=0.497 P=0.760 P=0.493 P=0.498N |
|POLY 6 | P=0.294N P=0.534 P=0.745N P=0.502 P=0.490N |
|LOGISTIC REGRESSION| P=0.296N P=0.470 P=0.753N P=0.436 P=0.494N |
|COCH-ARM / FISHERS | P=0.295N P=0.431 P=0.705 P=0.431 P=0.500N |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 89
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Testes: Germinal Epithelium |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 2/60 (3%) 2/50 (4%) 4/50 (8%) 4/50 (8%) 4/60 (7%) |
|POLY-3 ADJUSTED (b)| 5.3% 5.3% 10.4% 9.1% 9.3% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 1/12 (8%) 0/16 (0%) 2/21 (10%) 2/31 (7%) 0/27 (0%) |
|FIRST INCIDENCE | 733 507 702 621 502 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.443 P=0.663N P=0.537 P=0.655N P=0.550 |
|POLY 3 | P=0.272 P=0.694 P=0.346 P=0.414 P=0.401 |
|POLY 1.5 | P=0.234 P=0.684 P=0.329 P=0.365 P=0.368 |
|POLY 6 | P=0.345 P=0.692N P=0.360 P=0.473 P=0.455 |
|LOGISTIC REGRESSION| P=0.233 P=0.649 P=0.406 P=0.456 P=0.372 |
|COCH-ARM / FISHERS | P=0.217 P=0.619 P=0.257 P=0.257 P=0.340 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Testes: Germinal Epithelium |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | |
|POLY-3 ADJUSTED (b)| |
|INT SACRIFICE 1 (c)| |
|TERMINAL (d) | |
|FIRST INCIDENCE | |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | |
|POLY 3 | |
|POLY 1.5 | |
|POLY 6 | |
|LOGISTIC REGRESSION| |
|COCH-ARM / FISHERS | |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 90
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Testes: Interstitial Cell |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 10/60 (17%) 10/50 (20%) 6/50 (12%) 5/50 (10%) 8/60 (13%) |
|POLY-3 ADJUSTED (b)| 24.6% 24.1% 14.6% 11.1% 17.9% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 2/12 (17%) 0/16 (0%) 0/21 (0%) 1/31 (3%) 3/27 (11%) |
|FIRST INCIDENCE | 435 435 360 518 360 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.090N P=0.571 P=0.166N P=0.033N* P=0.166N |
|POLY 3 | P=0.140N P=0.585N P=0.194N P=0.086N P=0.310N |
|POLY 1.5 | P=0.167N P=0.583 P=0.215N P=0.115N P=0.350N |
|POLY 6 | P=0.108N P=0.559N P=0.183N P=0.061N P=0.257N |
|LOGISTIC REGRESSION| P=0.212N P=0.392 P=0.346N P=0.201N P=0.383N |
|COCH-ARM / FISHERS | P=0.201N P=0.418 P=0.340N P=0.232N P=0.399N |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Testes: Interstitial Cell |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | |
|POLY-3 ADJUSTED (b)| |
|INT SACRIFICE 1 (c)| |
|TERMINAL (d) | |
|FIRST INCIDENCE | |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | |
|POLY 3 | |
|POLY 1.5 | |
|POLY 6 | |
|LOGISTIC REGRESSION| |
|COCH-ARM / FISHERS | |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 91
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Thymus |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/59 (0%) 0/46 (0%) 0/49 (0%) 0/47 (0%) 0/58 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/15 (0%) 0/20 (0%) 0/28 (0%) 0/27 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Thymus |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/58 (0%) 1/44 (2%) 3/48 (6%) 0/47 (0%) 0/59 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 2.5% 7.3% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/26 (0%) 0/31 (0%) 3/33 (9%) 0/27 (0%) 0/28 (0%) |
|FIRST INCIDENCE | --- 392 738 (T) --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.409N P=0.496 P=0.165 (e) (e) |
|POLY 3 | P=0.354N P=0.500 P=0.128 (e) (e) |
|POLY 1.5 | P=0.362N P=0.486 P=0.119 (e) (e) |
|POLY 6 | P=0.351N P=0.514 P=0.137 (e) (e) |
|LOGISTIC REGRESSION| P=0.391N P=0.248 P=0.165 (e) (e) |
|COCH-ARM / FISHERS | P=0.390N P=0.431 P=0.090 (e) (e) |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 92
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Thymus |
| Ectopic Parathyroid Gland |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/59 (0%) 1/46 (2%) 0/49 (0%) 0/47 (0%) 0/58 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 3.0% 0.0% 0.0% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/12 (0%) 0/15 (0%) 0/20 (0%) 0/28 (0%) 0/27 (0%) |
|FIRST INCIDENCE | --- 708 --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.376N P=0.520 (e) (e) (e) |
|POLY 3 | P=0.393N P=0.476 (e) (e) (e) |
|POLY 1.5 | P=0.401N P=0.475 (e) (e) (e) |
|POLY 6 | P=0.393N P=0.474 (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.421N P=0.475 (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.451N P=0.438 (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Thymus |
| Ectopic Parathyroid Gland |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/58 (0%) 0/44 (0%) 0/48 (0%) 2/47 (4%) 0/59 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 0.0% 0.0% 5.1% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/26 (0%) 0/31 (0%) 0/33 (0%) 0/27 (0%) 0/28 (0%) |
|FIRST INCIDENCE | --- --- --- 634 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.409 (e) (e) P=0.222 (e) |
|POLY 3 | P=0.366 (e) (e) P=0.237 (e) |
|POLY 1.5 | P=0.367 (e) (e) P=0.229 (e) |
|POLY 6 | P=0.371 (e) (e) P=0.241 (e) |
|LOGISTIC REGRESSION| P=0.423 (e) (e) P=0.188 (e) |
|COCH-ARM / FISHERS | P=0.422 (e) (e) P=0.198 (e) |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 93
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 16/60 (27%) 8/50 (16%) 21/50 (42%) 19/50 (38%) 17/60 (28%) |
|POLY-3 ADJUSTED (b)| 39.7% 21.1% 50.5% 42.8% 38.4% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 5/12 (42%) 3/16 (19%) 11/21 (52%) 16/31 (52%) 11/27 (41%) |
|FIRST INCIDENCE | 579 507 521 619 360 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.152N P=0.042N* P=0.567N P=0.049N* P=0.105N |
|POLY 3 | P=0.290 P=0.056N P=0.215 P=0.471 P=0.541N |
|POLY 1.5 | P=0.216 P=0.061N P=0.181 P=0.370 P=0.573 |
|POLY 6 | P=0.431 P=0.060N P=0.234 P=0.569 P=0.454N |
|LOGISTIC REGRESSION| P=0.325 P=0.063N P=0.206 P=0.547N P=0.543N |
|COCH-ARM / FISHERS | P=0.207 P=0.132N P=0.068 P=0.143 P=0.500 |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 16/60 (27%) 23/50 (46%) 27/50 (54%) 20/50 (40%) 17/60 (28%) |
|POLY-3 ADJUSTED (b)| 37.6% 51.6% 60.3% 47.1% 38.3% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 9/28 (32%) 19/33 (58%) 21/34 (62%) 15/28 (54%) 12/28 (43%) |
|FIRST INCIDENCE | 620 430 544 572 365 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.501N P=0.272 P=0.113 P=0.259 P=0.529 |
|POLY 3 | P=0.324N P=0.132 P=0.024 * P=0.249 P=0.564 |
|POLY 1.5 | P=0.339N P=0.096 P=0.016 * P=0.229 P=0.531 |
|POLY 6 | P=0.333N P=0.164 P=0.032 * P=0.233 P=0.586 |
|LOGISTIC REGRESSION| P=0.366N P=0.130 P=0.029 * P=0.232 P=0.555 |
|COCH-ARM / FISHERS | P=0.340N P=0.028 * P=0.003 ** P=0.100 P=0.500 |
|=================================================================================================================================|
Date: 09/15/97 EXPERIMENT: 89002 TEST: 02 Page 94
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER344) - PENTACHLOROPHENOL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | | |
| | Males |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Uterus |
| Hydrometra |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | |
|POLY-3 ADJUSTED (b)| |
|INT SACRIFICE 1 (c)| |
|TERMINAL (d) | |
|FIRST INCIDENCE | |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | |
|POLY 3 | |
|POLY 1.5 | |
|POLY 6 | |
|LOGISTIC REGRESSION| |
|COCH-ARM / FISHERS | |
|=================================================================================================================================|
| | | |
| | Females |
|Dose | 0 PPM 200 PPM 400 PPM | 600 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Uterus |
| Hydrometra |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | |
|----------- | |
|OVERALL (a) | 0/60 (0%) 2/50 (4%) 0/50 (0%) 2/50 (4%) 0/60 (0%) |
|POLY-3 ADJUSTED (b)| 0.0% 4.7% 0.0% 4.9% 0.0% |
|INT SACRIFICE 1 (c)| 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) |
|TERMINAL (d) | 0/28 (0%) 2/33 (6%) 0/34 (0%) 1/28 (4%) 0/28 (0%) |
|FIRST INCIDENCE | --- 738 (T) --- 692 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.543N P=0.275 (e) P=0.226 (e) |
|POLY 3 | P=0.494N P=0.245 (e) P=0.235 (e) |
|POLY 1.5 | P=0.503N P=0.234 (e) P=0.231 (e) |
|POLY 6 | P=0.486N P=0.257 (e) P=0.233 (e) |
|LOGISTIC REGRESSION| P=0.524N P=0.275 (e) P=0.232 (e) |
|COCH-ARM / FISHERS | P=0.512N P=0.204 (e) P=0.204 (e) |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Poly-3 adjusted lifetime tumor incidence.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death.
Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).