TDMS Study 89002-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Battelle Columbus PENTACHLOROPHENOL DATE: 08/20/97
EXPERIMENT: 89002 TEST: 02 TIME: 12:37:28
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-15322 ROUTE: DOSED FEED NTP C#: C89002
PATHOLOGIST: TOFT, J. CAS: 87-86-5
------------------------------------------------------------------------------------------------------------------------------------
Control vs Stop Study
REASONS FOR REMOVAL: 25019 Moribund Sacrifice
25020 Natural Death
25021 Terminal Sacrifice
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE 001 0 PPM
INCLUDE 002 0 PPM
INCLUDE 009 1000 PPM
INCLUDE 010 1000 PPM
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Battelle Columbus PENTACHLOROPHENOL DATE: 08/20/97
EXPERIMENT: 89002 TEST: 02 TIME: 12:37:28
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-15322 ROUTE: DOSED FEED NTP C#: C89002
PATHOLOGIST: TOFT, J. CAS: 87-86-5
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF PENTACHLOROPHENOL
====================================================================================================
MALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Cortex Degeneration Fatty
Adrenal Medulla Hyperplasia
Bone Marrow Hyperplasia
Heart Cardiomyopathy Chronic
Thrombosis
Kidney Nephropathy Chronic
Pigmentation
Liver Basophilic Focus
Degeneration Cystic
Hepatodiaphragmatic Nodule
Hyperplasia
Inflammation Chronic
Lung Infiltration Cellular Histiocyte
Lymph Node Pigmentation Hemosiderin
Lymph Node, Mesenteric Ectasia
Mammary Gland Hyperplasia Cystic
Mesentery Necrosis
Nose Fungus
Hyperplasia
Inflammation Chronic
Metaplasia
Preputial Gland Inflammation Chronic
Prostate Inflammation Chronic
Stomach, Forestomach Inflammation Chronic
Ulcer
====================================================================================================
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Battelle Columbus PENTACHLOROPHENOL DATE: 08/20/97
EXPERIMENT: 89002 TEST: 02 TIME: 12:37:28
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-15322 ROUTE: DOSED FEED NTP C#: C89002
PATHOLOGIST: TOFT, J. CAS: 87-86-5
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF PENTACHLOROPHENOL
====================================================================================================
FEMALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Cortex Hyperplasia
Kidney Nephropathy Chronic
Nose Hyperplasia
Pituitary Gland Cyst
====================================================================================================
DATE: 08/20/97 EXPERIMENT: 89002 TEST: 02 PAGE 1
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 1000 PPM | 0 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Accessory Adrenal Cortical Nodule |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) | 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 4.9% | 3.6% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/27 (0%) | 1/28 (4%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | --- 565 | 738 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.273 | P=0.500N |
|INCIDENTAL TUMOR | P=0.111 | P=0.500N |
|LOGISTIC REGRESSION | P=0.224 | P=0.500N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.247 | P=0.500N |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Degeneration Cystic |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 1/50 (2%) | 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 8.3% 3.7% | 0.0% 5.8% |
|TERMINAL (d) | 1/12 (8%) 1/27 (4%) | 0/28 (0%) 1/28 (4%) |
|FIRST INCIDENCE (DAYS) | 736 (T) 736 (T) | --- 600 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.571N | P=0.250 |
|INCIDENTAL TUMOR | P=0.571N | P=0.240 |
|LOGISTIC REGRESSION | P=0.571N | P=0.238 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.753N | P=0.247 |
|=================================================================================================================================|
DATE: 08/20/97 EXPERIMENT: 89002 TEST: 02 PAGE 2
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 1000 PPM | 0 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Degeneration Fatty |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 28/50 (56%) 25/50 (50%) | 9/50 (18%) 14/50 (28%) |
|ADJUSTED (b) | 84.0% 60.5% | 25.5% 39.9% |
|TERMINAL (d) | 8/12 (67%) 12/27 (44%) | 4/28 (14%) 8/28 (29%) |
|FIRST INCIDENCE (DAYS) | 396 360 | 585 647 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.017N* | P=0.219 |
|INCIDENTAL TUMOR | P=0.362N | P=0.247 |
|LOGISTIC REGRESSION | P=0.354N | P=0.192 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.344N | P=0.171 |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Hyperplasia |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 13/50 (26%) 17/50 (34%) | 7/50 (14%) 17/50 (34%) |
|ADJUSTED (b) | 50.3% 52.9% | 23.7% 54.1% |
|TERMINAL (d) | 4/12 (33%) 13/27 (48%) | 6/28 (21%) 14/28 (50%) |
|FIRST INCIDENCE (DAYS) | 564 460 | 698 600 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.280N | P=0.016 * |
|INCIDENTAL TUMOR | P=0.464 | P=0.018 * |
|LOGISTIC REGRESSION | P=0.318 | P=0.022 * |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.257 | P=0.017 * |
|=================================================================================================================================|
DATE: 08/20/97 EXPERIMENT: 89002 TEST: 02 PAGE 3
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 1000 PPM | 0 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Hypertrophy |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 3/50 (6%) | 1/50 (2%) 3/50 (6%) |
|ADJUSTED (b) | 0.0% 9.8% | 3.6% 10.7% |
|TERMINAL (d) | 0/12 (0%) 2/27 (7%) | 1/28 (4%) 3/28 (11%) |
|FIRST INCIDENCE (DAYS) | --- 677 | 738 (T) 738 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.253 | P=0.304 |
|INCIDENTAL TUMOR | P=0.178 | P=0.304 |
|LOGISTIC REGRESSION | P=0.163 | P=0.304 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.121 | P=0.309 |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Hyperplasia |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 18/50 (36%) 28/50 (56%) | 3/50 (6%) 4/50 (8%) |
|ADJUSTED (b) | 73.1% 72.1% | 10.7% 11.2% |
|TERMINAL (d) | 6/12 (50%) 17/27 (63%) | 3/28 (11%) 2/28 (7%) |
|FIRST INCIDENCE (DAYS) | 647 460 | 738 (T) 516 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.396N | P=0.509 |
|INCIDENTAL TUMOR | P=0.072 | P=0.413 |
|LOGISTIC REGRESSION | P=0.080 | P=0.501 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.035 * | P=0.500 |
|=================================================================================================================================|
DATE: 08/20/97 EXPERIMENT: 89002 TEST: 02 PAGE 4
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 1000 PPM | 0 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Blood Vessel: Aorta |
| Mineralization |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 5.3% 6.4% | 0.0% 0.0% |
|TERMINAL (d) | 0/12 (0%) 1/27 (4%) | 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 715 684 | --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.670 | (e) (e) |
|INCIDENTAL TUMOR | P=0.468 | (e) (e) |
|LOGISTIC REGRESSION | P=0.575 | (e) (e) |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.500 | (e) |
|=================================================================================================================================|
| |
|Bone |
| Fibrous Osteodystrophy |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 3/50 (6%) | 0/50 (0%) 0/49 (0%) |
|ADJUSTED (b) | 5.3% 9.6% | 0.0% 0.0% |
|TERMINAL (d) | 0/12 (0%) 1/27 (4%) | 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 715 684 | --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.488 | (e) (e) |
|INCIDENTAL TUMOR | P=0.229 | (e) (e) |
|LOGISTIC REGRESSION | P=0.382 | (e) (e) |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.309 | (e) |
|=================================================================================================================================|
DATE: 08/20/97 EXPERIMENT: 89002 TEST: 02 PAGE 5
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 1000 PPM | 0 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Bone |
| Osteopetrosis |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) | 6/50 (12%) 2/49 (4%) |
|ADJUSTED (b) | 0.0% 0.0% | 18.8% 6.2% |
|TERMINAL (d) | 0/12 (0%) 0/27 (0%) | 3/28 (11%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- | 698 708 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) | P=0.127N |
|INCIDENTAL TUMOR | (e) (e) | P=0.098N |
|LOGISTIC REGRESSION | (e) (e) | P=0.124N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | (e) | P=0.141N |
|=================================================================================================================================|
| |
|Bone Marrow |
| Hyperplasia |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 30/50 (60%) 38/50 (76%) | 11/50 (22%) 16/49 (33%) |
|ADJUSTED (b) | 78.2% 85.9% | 28.6% 35.4% |
|TERMINAL (d) | 5/12 (42%) 21/27 (78%) | 3/28 (11%) 2/28 (7%) |
|FIRST INCIDENCE (DAYS) | 396 360 | 475 365 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.181N | P=0.263 |
|INCIDENTAL TUMOR | P=0.038 * | P=0.182 |
|LOGISTIC REGRESSION | P=0.081 | P=0.075 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.066 | P=0.168 |
|=================================================================================================================================|
DATE: 08/20/97 EXPERIMENT: 89002 TEST: 02 PAGE 6
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 1000 PPM | 0 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Brain |
| Hemorrhage |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 1/50 (2%) | 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 11.3% 3.7% | 0.0% 2.4% |
|TERMINAL (d) | 0/12 (0%) 1/27 (4%) | 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 564 736 (T) | --- 652 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.112N | P=0.520 |
|INCIDENTAL TUMOR | P=0.309N | P=0.548 |
|LOGISTIC REGRESSION | P=0.190N | P=0.503 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.181N | P=0.500 |
|=================================================================================================================================|
| |
|Clitoral Gland |
| Hyperplasia |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/0 (0%) 0/0 (0%) | 10/50 (20%) 10/49 (20%) |
|ADJUSTED (b) | 0.0% 0.0% | 29.8% 35.2% |
|TERMINAL (d) | 0/0 0/0 | 6/28 (21%) 9/27 (33%) |
|FIRST INCIDENCE (DAYS) | --- --- | 523 703 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) | P=0.587 |
|INCIDENTAL TUMOR | (e) (e) | P=0.566 |
|LOGISTIC REGRESSION | (e) (e) | P=0.577N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | (e) | P=0.579 |
|=================================================================================================================================|
DATE: 08/20/97 EXPERIMENT: 89002 TEST: 02 PAGE 7
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 1000 PPM | 0 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Clitoral Gland |
| Inflammation Chronic |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/0 (0%) 0/0 (0%) | 4/50 (8%) 3/49 (6%) |
|ADJUSTED (b) | 0.0% 0.0% | 10.5% 9.7% |
|TERMINAL (d) | 0/0 0/0 | 1/28 (4%) 2/27 (7%) |
|FIRST INCIDENCE (DAYS) | --- --- | 544 668 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) | P=0.482N |
|INCIDENTAL TUMOR | (e) (e) | P=0.558N |
|LOGISTIC REGRESSION | (e) (e) | P=0.510N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | (e) | P=0.511N |
|=================================================================================================================================|
| |
|Coagulating Gland |
| Inflammation Chronic |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 2/2 (100%) 0/0 (0%) | 0/0 (0%) 0/0 (0%) |
|ADJUSTED (b) | 12.8% 0.0% | 0.0% 0.0% |
|TERMINAL (d) | 0/0 0/0 | 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 715 --- | --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.123N | (e) (e) |
|INCIDENTAL TUMOR | (e) (e) | (e) (e) |
|LOGISTIC REGRESSION | (e) (e) | (e) (e) |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=1.000N | (e) |
|=================================================================================================================================|
DATE: 08/20/97 EXPERIMENT: 89002 TEST: 02 PAGE 8
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 1000 PPM | 0 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Eye |
| Atrophy |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/1 (0%) 0/3 (0%) | 2/3 (67%) 1/2 (50%) |
|ADJUSTED (b) | 0.0% 0.0% | 100.0% 2.7% |
|TERMINAL (d) | 0/0 0/1 (0%) | 2/2 (100%) 0/1 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- | 738 (T) 701 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) | P=0.667N |
|INCIDENTAL TUMOR | (e) (e) | P=0.686N |
|LOGISTIC REGRESSION | (e) (e) | P=0.737N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | (e) | P=0.700N |
|=================================================================================================================================|
| |
|Eye: Lens |
| Cataract |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 1/1 (100%) 3/3 (100%) | 0/3 (0%) 0/2 (0%) |
|ADJUSTED (b) | 2.0% 100.0% | 0.0% 0.0% |
|TERMINAL (d) | 0/0 1/1 (100%) | 0/2 (0%) 0/1 (0%) |
|FIRST INCIDENCE (DAYS) | 396 677 | --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.586 | (e) (e) |
|INCIDENTAL TUMOR | (e) (e) | (e) (e) |
|LOGISTIC REGRESSION | (e) (e) | (e) (e) |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=1.000N | (e) |
|=================================================================================================================================|
DATE: 08/20/97 EXPERIMENT: 89002 TEST: 02 PAGE 9
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 1000 PPM | 0 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Eye: Retina |
| Atrophy |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 1/1 (100%) 3/3 (100%) | 0/3 (0%) 0/2 (0%) |
|ADJUSTED (b) | 2.0% 100.0% | 0.0% 0.0% |
|TERMINAL (d) | 0/0 1/1 (100%) | 0/2 (0%) 0/1 (0%) |
|FIRST INCIDENCE (DAYS) | 396 677 | --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.586 | (e) (e) |
|INCIDENTAL TUMOR | (e) (e) | (e) (e) |
|LOGISTIC REGRESSION | (e) (e) | (e) (e) |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=1.000N | (e) |
|=================================================================================================================================|
| |
|Heart |
| Cardiomyopathy Chronic |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 42/50 (84%) 45/50 (90%) | 27/50 (54%) 25/50 (50%) |
|ADJUSTED (b) | 100.0% 97.8% | 66.1% 68.7% |
|TERMINAL (d) | 12/12 (100%) 26/27 (96%) | 15/28 (54%) 17/28 (61%) |
|FIRST INCIDENCE (DAYS) | 396 265 | 461 600 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.009N** | P=0.386N |
|INCIDENTAL TUMOR | P=0.471 | P=0.463N |
|LOGISTIC REGRESSION | P=0.338 | P=0.390N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.277 | P=0.421N |
|=================================================================================================================================|
DATE: 08/20/97 EXPERIMENT: 89002 TEST: 02 PAGE 10
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 1000 PPM | 0 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Heart: Atrium |
| Thrombosis |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 7/50 (14%) 1/50 (2%) | 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 40.8% 3.2% | 0.0% 2.5% |
|TERMINAL (d) | 3/12 (25%) 0/27 (0%) | 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 684 708 | --- 668 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.003N** | P=0.527 |
|INCIDENTAL TUMOR | P=0.028N* | P=0.548 |
|LOGISTIC REGRESSION | P=0.008N** | P=0.500 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.030N* | P=0.500 |
|=================================================================================================================================|
| |
|Intestine Large, Colon |
| Parasite Metazoan |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 3/49 (6%) | 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 8.3% 9.5% | 0.0% 3.6% |
|TERMINAL (d) | 1/12 (8%) 2/27 (7%) | 0/28 (0%) 1/28 (4%) |
|FIRST INCIDENCE (DAYS) | 736 (T) 565 | --- 738 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.536 | P=0.500 |
|INCIDENTAL TUMOR | P=0.451 | P=0.500 |
|LOGISTIC REGRESSION | P=0.327 | P=0.500 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.301 | P=0.500 |
|=================================================================================================================================|
DATE: 08/20/97 EXPERIMENT: 89002 TEST: 02 PAGE 11
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 1000 PPM | 0 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Intestine Large, Rectum |
| Parasite Metazoan |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 5/50 (10%) | 2/50 (4%) 4/50 (8%) |
|ADJUSTED (b) | 2.9% 18.5% | 7.1% 11.1% |
|TERMINAL (d) | 0/12 (0%) 5/27 (19%) | 2/28 (7%) 1/28 (4%) |
|FIRST INCIDENCE (DAYS) | 643 736 (T) | 738 (T) 516 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.322 | P=0.353 |
|INCIDENTAL TUMOR | P=0.251 | P=0.287 |
|LOGISTIC REGRESSION | P=0.177 | P=0.338 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.102 | P=0.339 |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Hyperplasia |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) | 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 16.7% 0.0% | 0.0% 3.6% |
|TERMINAL (d) | 2/12 (17%) 0/27 (0%) | 0/28 (0%) 1/28 (4%) |
|FIRST INCIDENCE (DAYS) | 736 (T) --- | --- 738 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.085N | P=0.500 |
|INCIDENTAL TUMOR | P=0.085N | P=0.500 |
|LOGISTIC REGRESSION | P=0.085N | P=0.500 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.247N | P=0.500 |
|=================================================================================================================================|
DATE: 08/20/97 EXPERIMENT: 89002 TEST: 02 PAGE 12
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 1000 PPM | 0 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Kidney |
| Cyst |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 3/50 (6%) | 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 3.6% 10.0% | 3.6% 0.0% |
|TERMINAL (d) | 0/12 (0%) 2/27 (7%) | 1/28 (4%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 681 684 | 738 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.508 | P=0.500N |
|INCIDENTAL TUMOR | P=0.345 | P=0.500N |
|LOGISTIC REGRESSION | P=0.372 | P=0.500N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.309 | P=0.500N |
|=================================================================================================================================|
| |
|Kidney |
| Nephropathy Chronic |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 50/50 (100%) 49/50 (98%) | 44/50 (88%) 49/50 (98%) |
|ADJUSTED (b) | 100.0% 100.0% | 100.0% 100.0% |
|TERMINAL (d) | 12/12 (100%) 27/27 (100%) | 28/28 (100%) 28/28 (100%) |
|FIRST INCIDENCE (DAYS) | 396 360 | 507 365 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.002N** | P=0.326 |
|INCIDENTAL TUMOR | (e) (e) | P=0.067 |
|LOGISTIC REGRESSION | (e) (e) | P=0.016 * |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.500N | P=0.056 |
|=================================================================================================================================|
DATE: 08/20/97 EXPERIMENT: 89002 TEST: 02 PAGE 13
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 1000 PPM | 0 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Hyperplasia |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) | 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 4.2% 6.8% | 0.0% 3.2% |
|TERMINAL (d) | 0/12 (0%) 1/27 (4%) | 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 695 708 | --- 719 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.687 | P=0.513 |
|INCIDENTAL TUMOR | P=0.468 | P=0.548 |
|LOGISTIC REGRESSION | P=0.579 | P=0.510 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.500 | P=0.500 |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Pigmentation |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 49/50 (98%) 47/50 (94%) | 48/50 (96%) 49/50 (98%) |
|ADJUSTED (b) | 100.0% 95.9% | 100.0% 100.0% |
|TERMINAL (d) | 12/12 (100%) 25/27 (93%) | 28/28 (100%) 28/28 (100%) |
|FIRST INCIDENCE (DAYS) | 396 265 | 391 365 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.002N** | P=0.546N |
|INCIDENTAL TUMOR | P=0.321N | P=0.366 |
|LOGISTIC REGRESSION | P=0.347N | P=0.291 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.309N | P=0.500 |
|=================================================================================================================================|
DATE: 08/20/97 EXPERIMENT: 89002 TEST: 02 PAGE 14
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 1000 PPM | 0 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Angiectasis |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 8.2% 7.4% | 0.0% 0.0% |
|TERMINAL (d) | 0/12 (0%) 2/27 (7%) | 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 647 736 (T) | --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.481N | (e) (e) |
|INCIDENTAL TUMOR | P=0.655N | (e) (e) |
|LOGISTIC REGRESSION | P=0.631N | (e) (e) |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.691N | (e) |
|=================================================================================================================================|
| |
|Liver |
| Basophilic Focus |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 17/50 (34%) 31/50 (62%) | 41/50 (82%) 34/50 (68%) |
|ADJUSTED (b) | 87.1% 93.7% | 97.5% 97.1% |
|TERMINAL (d) | 10/12 (83%) 25/27 (93%) | 27/28 (96%) 27/28 (96%) |
|FIRST INCIDENCE (DAYS) | 396 550 | 391 516 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.522N | P=0.088N |
|INCIDENTAL TUMOR | P=0.175 | P=0.170N |
|LOGISTIC REGRESSION | P=0.051 | P=0.058N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.004 ** | P=0.083N |
|=================================================================================================================================|
DATE: 08/20/97 EXPERIMENT: 89002 TEST: 02 PAGE 15
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 1000 PPM | 0 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Clear Cell Focus |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 9/50 (18%) | 11/50 (22%) 16/50 (32%) |
|ADJUSTED (b) | 50.0% 33.3% | 39.3% 54.8% |
|TERMINAL (d) | 6/12 (50%) 9/27 (33%) | 11/28 (39%) 15/28 (54%) |
|FIRST INCIDENCE (DAYS) | 736 (T) 736 (T) | 738 (T) 690 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.267N | P=0.155 |
|INCIDENTAL TUMOR | P=0.267N | P=0.160 |
|LOGISTIC REGRESSION | P=0.267N | P=0.179 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.288 | P=0.184 |
|=================================================================================================================================|
| |
|Liver |
| Eosinophilic Focus |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 7/50 (14%) | 2/50 (4%) 2/50 (4%) |
|ADJUSTED (b) | 9.3% 25.9% | 6.0% 7.1% |
|TERMINAL (d) | 0/12 (0%) 7/27 (26%) | 1/28 (4%) 2/28 (7%) |
|FIRST INCIDENCE (DAYS) | 619 736 (T) | 620 738 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.356 | P=0.690N |
|INCIDENTAL TUMOR | P=0.229 | P=0.694 |
|LOGISTIC REGRESSION | P=0.173 | P=0.686N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.080 | P=0.691N |
|=================================================================================================================================|
DATE: 08/20/97 EXPERIMENT: 89002 TEST: 02 PAGE 16
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 1000 PPM | 0 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Hepatodiaphragmatic Nodule |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 5/50 (10%) | 9/50 (18%) 10/50 (20%) |
|ADJUSTED (b) | 0.0% 17.2% | 26.9% 26.0% |
|TERMINAL (d) | 0/12 (0%) 3/27 (11%) | 6/28 (21%) 3/28 (11%) |
|FIRST INCIDENCE (DAYS) | --- 715 | 475 472 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.130 | P=0.535 |
|INCIDENTAL TUMOR | P=0.051 | P=0.460 |
|LOGISTIC REGRESSION | P=0.080 | P=0.500 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.028 * | P=0.500 |
|=================================================================================================================================|
| |
|Liver |
| Inflammation Chronic |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 22/50 (44%) 34/50 (68%) | 31/50 (62%) 36/50 (72%) |
|ADJUSTED (b) | 84.1% 82.0% | 83.1% 97.2% |
|TERMINAL (d) | 9/12 (75%) 20/27 (74%) | 22/28 (79%) 27/28 (96%) |
|FIRST INCIDENCE (DAYS) | 396 265 | 507 365 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.449N | P=0.236 |
|INCIDENTAL TUMOR | P=0.129 | P=0.170 |
|LOGISTIC REGRESSION | P=0.040 * | P=0.225 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.013 * | P=0.198 |
|=================================================================================================================================|
DATE: 08/20/97 EXPERIMENT: 89002 TEST: 02 PAGE 17
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 1000 PPM | 0 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Mixed Cell Focus |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 5/50 (10%) | 7/50 (14%) 5/50 (10%) |
|ADJUSTED (b) | 8.3% 18.5% | 25.0% 17.0% |
|TERMINAL (d) | 1/12 (8%) 5/27 (19%) | 7/28 (25%) 4/28 (14%) |
|FIRST INCIDENCE (DAYS) | 736 (T) 736 (T) | 738 (T) 714 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.371 | P=0.372N |
|INCIDENTAL TUMOR | P=0.371 | P=0.362N |
|LOGISTIC REGRESSION | P=0.371 | P=0.353N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.102 | P=0.380N |
|=================================================================================================================================|
| |
|Liver |
| Pigmentation Hemosiderin |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) | 1/50 (2%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 0.0% | 3.1% 4.5% |
|TERMINAL (d) | 0/12 (0%) 0/27 (0%) | 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- | 704 472 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) | P=0.526 |
|INCIDENTAL TUMOR | (e) (e) | P=0.422 |
|LOGISTIC REGRESSION | (e) (e) | P=0.522 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | (e) | P=0.500 |
|=================================================================================================================================|
DATE: 08/20/97 EXPERIMENT: 89002 TEST: 02 PAGE 18
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 1000 PPM | 0 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver |
| Thrombosis |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) | 2/50 (4%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 0.0% | 5.3% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/27 (0%) | 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- | 391 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) | P=0.241N |
|INCIDENTAL TUMOR | (e) (e) | P=0.331N |
|LOGISTIC REGRESSION | (e) (e) | P=0.186N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | (e) | P=0.247N |
|=================================================================================================================================|
| |
|Liver: Bile Duct |
| Hyperplasia |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 49/50 (98%) 46/50 (92%) | 24/50 (48%) 18/50 (36%) |
|ADJUSTED (b) | 100.0% 100.0% | 66.2% 54.0% |
|TERMINAL (d) | 12/12 (100%) 27/27 (100%) | 16/28 (57%) 13/28 (46%) |
|FIRST INCIDENCE (DAYS) | 396 265 | 585 647 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001N** | P=0.146N |
|INCIDENTAL TUMOR | P=0.113N | P=0.083N |
|LOGISTIC REGRESSION | P=0.149N | P=0.085N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.181N | P=0.156N |
|=================================================================================================================================|
DATE: 08/20/97 EXPERIMENT: 89002 TEST: 02 PAGE 19
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 1000 PPM | 0 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver: Hepatocyte |
| Degeneration Cystic |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 16/50 (32%) 28/50 (56%) | 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 60.3% 70.9% | 0.0% 0.0% |
|TERMINAL (d) | 4/12 (33%) 16/27 (59%) | 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 576 550 | --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.532 | (e) (e) |
|INCIDENTAL TUMOR | P=0.012 * | (e) (e) |
|LOGISTIC REGRESSION | P=0.035 * | (e) (e) |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.013 * | (e) |
|=================================================================================================================================|
| |
|Liver: Hepatocyte |
| Necrosis |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 2/50 (4%) | 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 8.3% 5.3% | 0.0% 2.6% |
|TERMINAL (d) | 0/12 (0%) 0/27 (0%) | 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 535 536 | --- 684 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.423N | P=0.522 |
|INCIDENTAL TUMOR | P=0.616 | P=0.548 |
|LOGISTIC REGRESSION | P=0.530N | P=0.500 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.500N | P=0.500 |
|=================================================================================================================================|
DATE: 08/20/97 EXPERIMENT: 89002 TEST: 02 PAGE 20
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 1000 PPM | 0 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver: Hepatocyte |
| Vacuolization Cytoplasmic |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 10/50 (20%) 13/50 (26%) | 7/50 (14%) 9/50 (18%) |
|ADJUSTED (b) | 33.1% 41.3% | 21.1% 28.0% |
|TERMINAL (d) | 1/12 (8%) 10/27 (37%) | 3/28 (11%) 6/28 (21%) |
|FIRST INCIDENCE (DAYS) | 396 536 | 645 684 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.384N | P=0.417 |
|INCIDENTAL TUMOR | P=0.383 | P=0.482 |
|LOGISTIC REGRESSION | P=0.325 | P=0.436 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.318 | P=0.393 |
|=================================================================================================================================|
| |
|Liver: Hepatocyte Centrilobular |
| Degeneration |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 2/50 (4%) | 0/50 (0%) 2/50 (4%) |
|ADJUSTED (b) | 8.8% 5.3% | 0.0% 5.9% |
|TERMINAL (d) | 0/12 (0%) 0/27 (0%) | 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 617 502 | --- 704 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.588N | P=0.257 |
|INCIDENTAL TUMOR | P=0.471 | P=0.290 |
|LOGISTIC REGRESSION | P=0.678 | P=0.243 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.691N | P=0.247 |
|=================================================================================================================================|
DATE: 08/20/97 EXPERIMENT: 89002 TEST: 02 PAGE 21
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 1000 PPM | 0 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Liver: Hepatocyte Centrilobular |
| Necrosis |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 2/50 (4%) | 2/50 (4%) 0/50 (0%) |
|ADJUSTED (b) | 14.4% 5.1% | 4.3% 0.0% |
|TERMINAL (d) | 1/12 (8%) 0/27 (0%) | 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 729 502 | 391 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.520N | P=0.237N |
|INCIDENTAL TUMOR | P=0.628 | P=0.366N |
|LOGISTIC REGRESSION | P=0.696 | P=0.142N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.691N | P=0.247N |
|=================================================================================================================================|
| |
|Lung |
| Inflammation Chronic |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 3/50 (6%) 6/50 (12%) | 12/50 (24%) 15/50 (30%) |
|ADJUSTED (b) | 10.3% 20.8% | 34.1% 47.1% |
|TERMINAL (d) | 0/12 (0%) 5/27 (19%) | 7/28 (25%) 12/28 (43%) |
|FIRST INCIDENCE (DAYS) | 396 684 | 523 516 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.547 | P=0.352 |
|INCIDENTAL TUMOR | P=0.328 | P=0.274 |
|LOGISTIC REGRESSION | P=0.248 | P=0.343 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.243 | P=0.326 |
|=================================================================================================================================|
DATE: 08/20/97 EXPERIMENT: 89002 TEST: 02 PAGE 22
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 1000 PPM | 0 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Lung: Alveolar Epithelium |
| Hyperplasia |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 3/50 (6%) | 5/50 (10%) 5/50 (10%) |
|ADJUSTED (b) | 8.3% 9.3% | 16.5% 16.5% |
|TERMINAL (d) | 1/12 (8%) 2/27 (7%) | 4/28 (14%) 4/28 (14%) |
|FIRST INCIDENCE (DAYS) | 736 (T) 460 | 645 684 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.538 | P=0.619N |
|INCIDENTAL TUMOR | P=0.479 | P=0.601N |
|LOGISTIC REGRESSION | P=0.303 | P=0.596N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.309 | P=0.630N |
|=================================================================================================================================|
| |
|Lung: Alveolus |
| Infiltration Cellular Histiocyte |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 39/50 (78%) 44/50 (88%) | 41/50 (82%) 46/50 (92%) |
|ADJUSTED (b) | 94.5% 93.5% | 100.0% 100.0% |
|TERMINAL (d) | 10/12 (83%) 24/27 (89%) | 28/28 (100%) 28/28 (100%) |
|FIRST INCIDENCE (DAYS) | 396 360 | 461 365 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.034N* | P=0.298 |
|INCIDENTAL TUMOR | P=0.150 | P=0.152 |
|LOGISTIC REGRESSION | P=0.176 | P=0.108 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.143 | P=0.117 |
|=================================================================================================================================|
DATE: 08/20/97 EXPERIMENT: 89002 TEST: 02 PAGE 23
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 1000 PPM | 0 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Lymph Node: Mediastinal |
| Pigmentation Hemosiderin |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 25/34 (74%) 24/28 (86%) | 30/35 (86%) 26/30 (87%) |
|ADJUSTED (b) | 87.4% 86.2% | 96.2% 100.0% |
|TERMINAL (d) | 5/7 (71%) 13/16 (81%) | 18/19 (95%) 13/13 (100%) |
|FIRST INCIDENCE (DAYS) | 396 502 | 507 571 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.025N* | P=0.514 |
|INCIDENTAL TUMOR | P=0.172 | P=0.592 |
|LOGISTIC REGRESSION | P=0.137 | P=0.633N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.196 | P=0.600 |
|=================================================================================================================================|
| |
|Lymph Node, Mesenteric |
| Ectasia |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 6/50 (12%) | 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 20.5% | 0.0% 0.0% |
|TERMINAL (d) | 0/12 (0%) 5/27 (19%) | 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | --- 614 | --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.084 | (e) (e) |
|INCIDENTAL TUMOR | P=0.055 | (e) (e) |
|LOGISTIC REGRESSION | P=0.031 * | (e) (e) |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.013 * | (e) |
|=================================================================================================================================|
DATE: 08/20/97 EXPERIMENT: 89002 TEST: 02 PAGE 24
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 1000 PPM | 0 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Lymph Node, Mesenteric |
| Hyperplasia Lymphoid |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 3/50 (6%) | 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 8.5% | 0.0% 0.0% |
|TERMINAL (d) | 0/12 (0%) 1/27 (4%) | 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | --- 360 | --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.201 | (e) (e) |
|INCIDENTAL TUMOR | P=0.257 | (e) (e) |
|LOGISTIC REGRESSION | P=0.108 | (e) (e) |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.121 | (e) |
|=================================================================================================================================|
| |
|Mammary Gland |
| Cyst |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/49 (0%) 2/49 (4%) | 2/50 (4%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 7.4% | 7.1% 0.0% |
|TERMINAL (d) | 0/12 (0%) 2/27 (7%) | 2/28 (7%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | --- 736 (T) | 738 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.429 | P=0.238N |
|INCIDENTAL TUMOR | P=0.429 | P=0.238N |
|LOGISTIC REGRESSION | P=0.429 | P=0.238N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.247 | P=0.247N |
|=================================================================================================================================|
DATE: 08/20/97 EXPERIMENT: 89002 TEST: 02 PAGE 25
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 1000 PPM | 0 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Hyperplasia Cystic |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 36/49 (73%) 26/49 (53%) | 43/50 (86%) 45/50 (90%) |
|ADJUSTED (b) | 88.9% 73.7% | 91.3% 97.8% |
|TERMINAL (d) | 8/12 (67%) 18/27 (67%) | 24/28 (86%) 27/28 (96%) |
|FIRST INCIDENCE (DAYS) | 396 613 | 461 365 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001N** | P=0.509 |
|INCIDENTAL TUMOR | P=0.024N* | P=0.343 |
|LOGISTIC REGRESSION | P=0.011N* | P=0.353 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.029N* | P=0.380 |
|=================================================================================================================================|
| |
|Mesentery: Fat |
| Necrosis |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 12/15 (80%) 11/15 (73%) | 3/8 (38%) 3/6 (50%) |
|ADJUSTED (b) | 100.0% 100.0% | 41.2% 100.0% |
|TERMINAL (d) | 3/3 (100%) 9/9 (100%) | 2/5 (40%) 1/1 (100%) |
|FIRST INCIDENCE (DAYS) | 593 680 | 391 600 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.013N* | P=0.314 |
|INCIDENTAL TUMOR | P=0.407N | P=0.541 |
|LOGISTIC REGRESSION | P=0.542N | P=0.531 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.500N | P=0.529 |
|=================================================================================================================================|
DATE: 08/20/97 EXPERIMENT: 89002 TEST: 02 PAGE 26
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 1000 PPM | 0 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Nose |
| Fungus |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 21/50 (42%) 7/50 (14%) | 6/50 (12%) 2/50 (4%) |
|ADJUSTED (b) | 71.5% 20.2% | 15.5% 5.9% |
|TERMINAL (d) | 6/12 (50%) 2/27 (7%) | 1/28 (4%) 1/28 (4%) |
|FIRST INCIDENCE (DAYS) | 396 565 | 461 652 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001N** | P=0.135N |
|INCIDENTAL TUMOR | P=0.009N** | P=0.196N |
|LOGISTIC REGRESSION | P=0.002N** | P=0.126N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.002N** | P=0.134N |
|=================================================================================================================================|
| |
|Nose |
| Inflammation Chronic |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 25/50 (50%) 21/50 (42%) | 13/50 (26%) 7/50 (14%) |
|ADJUSTED (b) | 79.1% 59.3% | 36.0% 19.7% |
|TERMINAL (d) | 7/12 (58%) 13/27 (48%) | 7/28 (25%) 3/28 (11%) |
|FIRST INCIDENCE (DAYS) | 396 565 | 461 11 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.007N** | P=0.112N |
|INCIDENTAL TUMOR | P=0.264N | P=0.075N |
|LOGISTIC REGRESSION | P=0.197N | P=0.103N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.274N | P=0.105N |
|=================================================================================================================================|
DATE: 08/20/97 EXPERIMENT: 89002 TEST: 02 PAGE 27
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 1000 PPM | 0 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Nose: Nasolacrimal Duct |
| Inflammation |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 6/50 (12%) 4/50 (8%) | 9/50 (18%) 10/50 (20%) |
|ADJUSTED (b) | 28.5% 11.0% | 26.4% 28.4% |
|TERMINAL (d) | 1/12 (8%) 1/27 (4%) | 5/28 (18%) 5/28 (18%) |
|FIRST INCIDENCE (DAYS) | 617 613 | 523 11 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.157N | P=0.528 |
|INCIDENTAL TUMOR | P=0.573N | P=0.586N |
|LOGISTIC REGRESSION | P=0.321N | P=0.500 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.370N | P=0.500 |
|=================================================================================================================================|
| |
|Nose: Respiratory Epithelium |
| Hyperplasia |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 24/50 (48%) 11/50 (22%) | 10/50 (20%) 2/50 (4%) |
|ADJUSTED (b) | 78.8% 32.3% | 28.0% 5.9% |
|TERMINAL (d) | 7/12 (58%) 5/27 (19%) | 5/28 (18%) 1/28 (4%) |
|FIRST INCIDENCE (DAYS) | 396 565 | 461 652 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P<0.001N** | P=0.018N* |
|INCIDENTAL TUMOR | P=0.015N* | P=0.026N* |
|LOGISTIC REGRESSION | P=0.004N** | P=0.016N* |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.006N** | P=0.014N* |
|=================================================================================================================================|
DATE: 08/20/97 EXPERIMENT: 89002 TEST: 02 PAGE 28
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 1000 PPM | 0 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Nose: Respiratory Epithelium |
| Metaplasia |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 12/50 (24%) 5/50 (10%) | 3/50 (6%) 0/50 (0%) |
|ADJUSTED (b) | 37.4% 14.5% | 9.0% 0.0% |
|TERMINAL (d) | 1/12 (8%) 1/27 (4%) | 1/28 (4%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 396 565 | 543 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.017N* | P=0.125N |
|INCIDENTAL TUMOR | P=0.269N | P=0.169N |
|LOGISTIC REGRESSION | P=0.067N | P=0.120N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.054N | P=0.121N |
|=================================================================================================================================|
| |
|Ovary |
| Cyst |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | | 4/50 (8%) 7/50 (14%) |
|ADJUSTED (b) | | 12.8% 21.0% |
|TERMINAL (d) | | 3/28 (11%) 4/28 (14%) |
|FIRST INCIDENCE (DAYS) | | 573 571 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.282 |
|INCIDENTAL TUMOR | | P=0.287 |
|LOGISTIC REGRESSION | | P=0.270 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | | P=0.262 |
|=================================================================================================================================|
DATE: 08/20/97 EXPERIMENT: 89002 TEST: 02 PAGE 29
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 1000 PPM | 0 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Pancreas: Acinus |
| Atrophy |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 12/50 (24%) 19/50 (38%) | 10/50 (20%) 13/50 (26%) |
|ADJUSTED (b) | 52.6% 54.0% | 30.2% 37.5% |
|TERMINAL (d) | 4/12 (33%) 12/27 (44%) | 6/28 (21%) 8/28 (29%) |
|FIRST INCIDENCE (DAYS) | 600 502 | 585 472 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.477N | P=0.351 |
|INCIDENTAL TUMOR | P=0.168 | P=0.341 |
|LOGISTIC REGRESSION | P=0.163 | P=0.337 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.097 | P=0.318 |
|=================================================================================================================================|
| |
|Parathyroid Gland |
| Hyperplasia |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 9/47 (19%) 7/47 (15%) | 1/46 (2%) 1/45 (2%) |
|ADJUSTED (b) | 42.2% 20.3% | 3.1% 3.0% |
|TERMINAL (d) | 3/12 (25%) 1/26 (4%) | 0/25 (0%) 0/26 (0%) |
|FIRST INCIDENCE (DAYS) | 681 680 | 704 708 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.110N | P=0.743N |
|INCIDENTAL TUMOR | P=0.565N | P=0.746N |
|LOGISTIC REGRESSION | P=0.385N | P=0.763N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.392N | P=0.747 |
|=================================================================================================================================|
DATE: 08/20/97 EXPERIMENT: 89002 TEST: 02 PAGE 30
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 1000 PPM | 0 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis |
| Cyst |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 7/50 (14%) 6/50 (12%) | 35/50 (70%) 24/50 (48%) |
|ADJUSTED (b) | 37.4% 19.4% | 86.9% 60.1% |
|TERMINAL (d) | 3/12 (25%) 4/27 (15%) | 23/28 (82%) 13/28 (46%) |
|FIRST INCIDENCE (DAYS) | 579 614 | 475 472 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.137N | P=0.037N* |
|INCIDENTAL TUMOR | P=0.386N | P=0.033N* |
|LOGISTIC REGRESSION | P=0.378N | P=0.019N* |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.500N | P=0.021N* |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis |
| Hyperplasia |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 22/50 (44%) 26/50 (52%) | 24/50 (48%) 24/50 (48%) |
|ADJUSTED (b) | 74.7% 71.2% | 65.1% 60.3% |
|TERMINAL (d) | 6/12 (50%) 17/27 (63%) | 16/28 (57%) 13/28 (46%) |
|FIRST INCIDENCE (DAYS) | 593 565 | 475 365 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.088N | P=0.524N |
|INCIDENTAL TUMOR | P=0.387 | P=0.528N |
|LOGISTIC REGRESSION | P=0.483 | P=0.569N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.274 | P=0.579N |
|=================================================================================================================================|
DATE: 08/20/97 EXPERIMENT: 89002 TEST: 02 PAGE 31
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 1000 PPM | 0 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Intermedia |
| Cyst |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) | 1/50 (2%) 2/50 (4%) |
|ADJUSTED (b) | 0.0% 0.0% | 2.9% 7.1% |
|TERMINAL (d) | 0/12 (0%) 0/27 (0%) | 0/28 (0%) 2/28 (7%) |
|FIRST INCIDENCE (DAYS) | --- --- | 698 738 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) | P=0.510 |
|INCIDENTAL TUMOR | (e) (e) | P=0.528 |
|LOGISTIC REGRESSION | (e) (e) | P=0.520 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | (e) | P=0.500 |
|=================================================================================================================================|
| |
|Preputial Gland |
| Hyperplasia |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 7/50 (14%) 8/49 (16%) | 0/0 (0%) 0/0 (0%) |
|ADJUSTED (b) | 44.8% 26.4% | 0.0% 0.0% |
|TERMINAL (d) | 5/12 (42%) 6/27 (22%) | 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 396 613 | --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.211N | (e) (e) |
|INCIDENTAL TUMOR | P=0.377N | (e) (e) |
|LOGISTIC REGRESSION | P=0.580 | (e) (e) |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.483 | (e) |
|=================================================================================================================================|
DATE: 08/20/97 EXPERIMENT: 89002 TEST: 02 PAGE 32
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 1000 PPM | 0 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Preputial Gland |
| Inflammation Chronic |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 42/50 (84%) 44/49 (90%) | 0/0 (0%) 0/0 (0%) |
|ADJUSTED (b) | 100.0% 97.7% | 0.0% 0.0% |
|TERMINAL (d) | 12/12 (100%) 26/27 (96%) | 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 396 360 | --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.004N** | (e) (e) |
|INCIDENTAL TUMOR | P=0.500 | (e) (e) |
|LOGISTIC REGRESSION | P=0.377 | (e) (e) |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.290 | (e) |
|=================================================================================================================================|
| |
|Preputial Gland: Duct |
| Cyst |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/49 (0%) | 0/0 (0%) 0/0 (0%) |
|ADJUSTED (b) | 9.2% 0.0% | 0.0% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/27 (0%) | 0/0 0/0 |
|FIRST INCIDENCE (DAYS) | 561 --- | --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.172N | (e) (e) |
|INCIDENTAL TUMOR | P=0.402N | (e) (e) |
|LOGISTIC REGRESSION | P=0.249N | (e) (e) |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.253N | (e) |
|=================================================================================================================================|
DATE: 08/20/97 EXPERIMENT: 89002 TEST: 02 PAGE 33
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 1000 PPM | 0 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Prostate |
| Inflammation Chronic |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 38/50 (76%) 37/50 (74%) | |
|ADJUSTED (b) | 88.9% 92.1% | |
|TERMINAL (d) | 8/12 (67%) 24/27 (89%) | |
|FIRST INCIDENCE (DAYS) | 396 360 | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.007N** | |
|INCIDENTAL TUMOR | P=0.401N | |
|LOGISTIC REGRESSION | P=0.486N | |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.500N | |
|=================================================================================================================================|
| |
|Skin |
| Cyst Epithelial Inclusion |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) | 0/50 (0%) 1/50 (2%) |
|ADJUSTED (b) | 0.0% 7.4% | 0.0% 3.6% |
|TERMINAL (d) | 0/12 (0%) 2/27 (7%) | 0/28 (0%) 1/28 (4%) |
|FIRST INCIDENCE (DAYS) | --- 736 (T) | --- 738 (T) |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.429 | P=0.500 |
|INCIDENTAL TUMOR | P=0.429 | P=0.500 |
|LOGISTIC REGRESSION | P=0.429 | P=0.500 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.247 | P=0.500 |
|=================================================================================================================================|
DATE: 08/20/97 EXPERIMENT: 89002 TEST: 02 PAGE 34
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 1000 PPM | 0 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Skin: Epidermis |
| Hyperkeratosis |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 0/50 (0%) 4/50 (8%) | 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 0.0% 14.2% | 0.0% 0.0% |
|TERMINAL (d) | 0/12 (0%) 3/27 (11%) | 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | --- 715 | --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.186 | (e) (e) |
|INCIDENTAL TUMOR | P=0.125 | (e) (e) |
|LOGISTIC REGRESSION | P=0.132 | (e) (e) |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.059 | (e) |
|=================================================================================================================================|
| |
|Spleen |
| Fibrosis |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 5/50 (10%) 6/50 (12%) | 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 35.1% 22.2% | 2.9% 0.0% |
|TERMINAL (d) | 4/12 (33%) 6/27 (22%) | 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 603 736 (T) | 696 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.244N | P=0.489N |
|INCIDENTAL TUMOR | P=0.294N | P=0.452N |
|LOGISTIC REGRESSION | P=0.515N | P=0.498N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.500 | P=0.500N |
|=================================================================================================================================|
DATE: 08/20/97 EXPERIMENT: 89002 TEST: 02 PAGE 35
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 1000 PPM | 0 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Spleen |
| Hematopoietic Cell Proliferation |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 4/50 (8%) 3/50 (6%) | 9/50 (18%) 7/50 (14%) |
|ADJUSTED (b) | 18.1% 8.1% | 26.6% 16.3% |
|TERMINAL (d) | 1/12 (8%) 0/27 (0%) | 5/28 (18%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 396 614 | 391 365 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.327N | P=0.378N |
|INCIDENTAL TUMOR | P=0.599 | P=0.323N |
|LOGISTIC REGRESSION | P=0.526N | P=0.385N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.500N | P=0.393N |
|=================================================================================================================================|
| |
|Spleen |
| Necrosis |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) | 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 10.9% 0.0% | 2.4% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/27 (0%) | 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 690 --- | 573 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.139N | P=0.486N |
|INCIDENTAL TUMOR | P=0.359N | P=0.500N |
|LOGISTIC REGRESSION | P=0.188N | P=0.469N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.247N | P=0.500N |
|=================================================================================================================================|
DATE: 08/20/97 EXPERIMENT: 89002 TEST: 02 PAGE 36
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 1000 PPM | 0 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Inflammation Chronic |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 10/50 (20%) 2/50 (4%) | 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 39.7% 5.4% | 3.4% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/27 (0%) | 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 579 265 | 731 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.004N** | P=0.507N |
|INCIDENTAL TUMOR | P=0.041N* | P=0.452N |
|LOGISTIC REGRESSION | P=0.017N* | P=0.489N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.014N* | P=0.500N |
|=================================================================================================================================|
| |
|Stomach, Forestomach: Epithelium |
| Hyperplasia |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 8/50 (16%) 4/50 (8%) | 3/50 (6%) 4/50 (8%) |
|ADJUSTED (b) | 30.6% 10.7% | 8.5% 11.2% |
|TERMINAL (d) | 0/12 (0%) 1/27 (4%) | 0/28 (0%) 1/28 (4%) |
|FIRST INCIDENCE (DAYS) | 579 265 | 543 472 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.074N | P=0.520 |
|INCIDENTAL TUMOR | P=0.156N | P=0.395 |
|LOGISTIC REGRESSION | P=0.209N | P=0.504 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.178N | P=0.500 |
|=================================================================================================================================|
DATE: 08/20/97 EXPERIMENT: 89002 TEST: 02 PAGE 37
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 1000 PPM | 0 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Stomach, Forestomach: Epithelium |
| Ulcer |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 8/50 (16%) 1/50 (2%) | 2/50 (4%) 0/50 (0%) |
|ADJUSTED (b) | 35.1% 3.4% | 5.5% 0.0% |
|TERMINAL (d) | 0/12 (0%) 0/27 (0%) | 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 600 715 | 475 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.003N** | P=0.246N |
|INCIDENTAL TUMOR | P=0.086N | P=0.331N |
|LOGISTIC REGRESSION | P=0.009N** | P=0.214N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.015N* | P=0.247N |
|=================================================================================================================================|
| |
|Stomach, Glandular |
| Mineralization |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) | 0/50 (0%) 0/50 (0%) |
|ADJUSTED (b) | 5.3% 6.4% | 0.0% 0.0% |
|TERMINAL (d) | 0/12 (0%) 1/27 (4%) | 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 715 684 | --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.670 | (e) (e) |
|INCIDENTAL TUMOR | P=0.468 | (e) (e) |
|LOGISTIC REGRESSION | P=0.575 | (e) (e) |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.500 | (e) |
|=================================================================================================================================|
DATE: 08/20/97 EXPERIMENT: 89002 TEST: 02 PAGE 38
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 1000 PPM | 0 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Stomach, Glandular: Epithelium |
| Erosion |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) | 1/50 (2%) 0/50 (0%) |
|ADJUSTED (b) | 10.7% 3.2% | 2.9% 0.0% |
|TERMINAL (d) | 1/12 (8%) 0/27 (0%) | 0/28 (0%) 0/28 (0%) |
|FIRST INCIDENCE (DAYS) | 603 708 | 696 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.343N | P=0.489N |
|INCIDENTAL TUMOR | P=0.560N | P=0.452N |
|LOGISTIC REGRESSION | P=0.485N | P=0.498N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.500N | P=0.500N |
|=================================================================================================================================|
| |
|Testes: Germinal Epithelium |
| Atrophy |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 2/50 (4%) 4/50 (8%) | |
|ADJUSTED (b) | 14.9% 10.4% | |
|TERMINAL (d) | 1/12 (8%) 0/27 (0%) | |
|FIRST INCIDENCE (DAYS) | 733 502 | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.550 | |
|INCIDENTAL TUMOR | P=0.203 | |
|LOGISTIC REGRESSION | P=0.342 | |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.339 | |
|=================================================================================================================================|
DATE: 08/20/97 EXPERIMENT: 89002 TEST: 02 PAGE 39
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 106 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | 0 PPM 1000 PPM | 0 PPM 1000 PPM |
| | | |
|=================================================================================================================================|
| |
|Testes: Interstitial Cell |
| Hyperplasia |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 10/50 (20%) 8/50 (16%) | |
|ADJUSTED (b) | 37.0% 20.9% | |
|TERMINAL (d) | 2/12 (17%) 3/27 (11%) | |
|FIRST INCIDENCE (DAYS) | 435 360 | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.166N | |
|INCIDENTAL TUMOR | P=0.442N | |
|LOGISTIC REGRESSION | P=0.474N | |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.398N | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Hyperplasia |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | | |
|----------- | | |
|OVERALL (a) | 16/50 (32%) 17/50 (34%) | 16/50 (32%) 17/50 (34%) |
|ADJUSTED (b) | 62.5% 49.0% | 45.2% 49.9% |
|TERMINAL (d) | 5/12 (42%) 11/27 (41%) | 9/28 (32%) 12/28 (43%) |
|FIRST INCIDENCE (DAYS) | 579 360 | 620 365 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.105N | P=0.529 |
|INCIDENTAL TUMOR | P=0.458N | P=0.493N |
|LOGISTIC REGRESSION | P=0.580 | P=0.543 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.500 | P=0.500 |
|=================================================================================================================================|
DATE: 08/20/97 EXPERIMENT: 89002 TEST: 02 PAGE 40
STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS IN RATS(FISCHER344) -- PENTACHLOROPHENOL
TERMINAL SACRIFICE AT 106 WEEKS
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).