TDMS Study 89002-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus PENTACHLOROPHENOL DATE: 08/19/97
EXPERIMENT: 89002 TEST: 02 TIME: 11:02:11
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-15322 ROUTE: DOSED FEED NTP C#: C89002
PATHOLOGIST: TOFT, J. CAS: 87-86-5
------------------------------------------------------------------------------------------------------------------------------------
Core Study
REASONS FOR REMOVAL: 25019 Moribund Sacrifice
25020 Natural Death
25021 Terminal Sacrifice
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE 001 0 PPM
INCLUDE 002 0 PPM
INCLUDE 003 200 PPM
INCLUDE 004 200 PPM
INCLUDE 005 400 PPM
INCLUDE 006 400 PPM
INCLUDE 007 600 PPM
INCLUDE 008 600 PPM
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus PENTACHLOROPHENOL DATE: 08/19/97
EXPERIMENT: 89002 TEST: 02 TIME: 11:02:11
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-15322 ROUTE: DOSED FEED NTP C#: C89002
PATHOLOGIST: TOFT, J. CAS: 87-86-5
PENTACHLOROPHENOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 736 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 38 CENSORED DEATHS 0 TERMINAL 12 |
| |
| UNCENSORED DEATHS |
| 396 396 420 435 535 561 564 576 579 593 |
| 600 600 603 617 619 643 645 646 647 660 |
| 663 675 681 684 684 690 695 698 698 702 |
| 703 715 715 722 724 729 733 733 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 200 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 34 CENSORED DEATHS 0 TERMINAL 16 |
| |
| UNCENSORED DEATHS |
| 410 428 435 450 505 507 524 534 544 544 |
| 563 563 579 592 605 614 619 619 631 634 |
| 647 649 660 663 663 684 698 698 702 708 |
| 722 723 723 726 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 400 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 29 CENSORED DEATHS 0 TERMINAL 21 |
| |
| UNCENSORED DEATHS |
| 360 443 482 521 527 557 561 563 572 583 |
| 593 593 605 617 619 620 624 640 640 645 |
| 648 666 676 688 698 702 711 722 729 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
PENTACHLOROPHENOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 736 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 600 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 19 CENSORED DEATHS 0 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 213 518 544 561 605 610 614 619 620 621 |
| 660 684 702 707 708 708 709 712 731 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
PENTACHLOROPHENOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 736 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 736 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 100.0 100.0 100.0 94.0 92.0 90.0 74.0 58.0 24.0 |
| | |
| | |
|200 PPM | 100.0 100.0 100.0 100.0 98.0 92.0 80.0 70.0 50.0 32.0 |
| | |
| | |
|400 PPM | 100.0 100.0 100.0 98.0 98.0 94.0 90.0 74.0 58.0 42.0 |
| | |
| | |
|600 PPM | 100.0 100.0 98.0 98.0 98.0 98.0 94.0 90.0 78.0 62.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 200 PPM 400 PPM 600 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 24.0% 32.0% 42.0% 62.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P=0.810N P=0.239N P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 631.0 604.9 607.1 623.5 |
|NATURAL DEATHS (C) | (15.2) (15.8) (15.8) (27.0) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 656.2 646.8 661.2 693.2 |
|(STANDARD ERROR) | (13.2) (13.8) (12.9) (12.8) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
PENTACHLOROPHENOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 738 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 22 CENSORED DEATHS 0 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 391 461 475 507 523 543 544 569 573 585 |
| 620 645 648 663 663 696 698 698 704 705 |
| 715 731 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 200 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 17 CENSORED DEATHS 0 TERMINAL 33 |
| |
| UNCENSORED DEATHS |
| 284 337 392 430 522 535 535 620 620 650 |
| 698 700 701 715 715 726 731 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 400 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 16 CENSORED DEATHS 0 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 399 417 451 535 544 563 592 600 614 625 |
| 647 670 684 690 721 733 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
PENTACHLOROPHENOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 738 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 600 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 22 CENSORED DEATHS 0 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 417 444 459 571 572 586 586 588 592 605 |
| 605 613 632 634 634 642 646 684 690 692 |
| 704 722 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
PENTACHLOROPHENOL
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 738 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 738 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 100.0 100.0 100.0 98.0 94.0 86.0 80.0 70.0 56.0 |
| | |
| | |
|200 PPM | 100.0 100.0 100.0 96.0 94.0 92.0 86.0 86.0 80.0 66.0 |
| | |
| | |
|400 PPM | 100.0 100.0 100.0 100.0 96.0 94.0 90.0 84.0 78.0 68.0 |
| | |
| | |
|600 PPM | 100.0 100.0 100.0 100.0 98.0 94.0 94.0 78.0 66.0 56.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 200 PPM 400 PPM 600 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 56.0% 66.0% 68.0% 56.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=1.000 P=0.386N P=0.319N P=1.000 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 607.1 583.0 592.8 605.4 |
|NATURAL DEATHS (C) | (20.5) (35.5) (25.8) (17.2) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 680.4 685.3 691.5 679.6 |
|(STANDARD ERROR) | (12.9) (15.8) (12.6) (12.0) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
PENTACHLOROPHENOL
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
200 PPM = 2
400 PPM = 3
600 PPM = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 3 1 2
| 4 3 2 2 3 4
| 1 1 213 2 3 4 3 4 4
| 1 2 2 331 4 4
90 + 31 31 44
| 2 2 33
| 2 22 131 44
| 313 1
P 80 + 2 2 3 11 4 4
E | 4 4
R | 2 2 211 1 4 4
C | 2 2 44
E 70 + 221 1
N | 223 11
T | 2323 4 4
| 31 1 44
S 60 + 2 2
U | 3 131
R | 2 23113
V | 33
I 50 + 2 1133
V | 21133
A | 223 3 3
L | 112 33
40 + 2 2
| 1 1
| 11
| 2 2
30 + 1 1
|
| 11
|
20 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 25 obs hidden.
PENTACHLOROPHENOL
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
200 PPM = 2
400 PPM = 3
600 PPM = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 13 4
|
| 2 2 13 3 4 1
| 2 2 3 4 31 1
95 +
| 2 2 34 1 1 3 4
| 2 1 1 33
|
90 + 1 21 34 4
|
P | 3 3
E | 21 1 33 2
R 85 +
C | 4 43 3
E | 1 1 4 4323 2
N |
T 80 + 1 13 2 2
|
S | 441 1 3
U | 4 4 3 3 22
R 75 +
V | 1 1 33 2 2
I | 3 3
V |
A 70 + 44 1 1 22 3
L |
| 44 2 23
| 4 4 22
65 +
| 4411
|
|
60 + 4 1 1
|
| 4 14 1
| 4 11
55 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 14 obs hidden.