Incidence Rates of Neoplasms by Anatomic Site
NTP Experiment-Test: 91014-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/14/97
Route: SKIN APPLICATION Time: 13:31:08
Facility: Battelle Columbus Laboratory
Chemical CAS #: 93-83-4
Lock Date: 01/02/96
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 91014-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/14/97
Route: SKIN APPLICATION Time: 13:31:08
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 50 MG/KG 100MG/KG
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DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Natural Death 24 23 31
Moribund Sacrifice 11 9 5
Survivors
Terminal Sacrifice 15 18 14
Animals Examined Microscopically 50 50 50
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ALIMENTARY SYSTEM
Esophagus (49) (50) (50)
Lipoma 1 (2%)
Intestine Small, Duodenum (50) (50) (50)
Carcinoma 1 (2%)
Liver (50) (50) (50)
Hepatocellular Adenoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Pancreas (50) (50) (50)
Salivary Glands (50) (50) (50)
Schwannoma Malignant 1 (2%)
Stomach, Forestomach (50) (50) (50)
Tongue (1)
Squamous Cell Papilloma 1 (100%)
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CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50) (50)
Heart (50) (50) (50)
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ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50)
Adrenal Medulla (50) (50) (50)
Pheochromocytoma Benign 2 (4%) 1 (2%)
Pituitary Gland (50) (50) (50)
Pars Distalis, Adenoma 26 (52%) 19 (38%) 17 (34%)
Pars Distalis, Adenoma, Multiple 3 (6%) 1 (2%) 2 (4%)
Thyroid Gland (50) (50) (50)
Bilateral, C-Cell, Adenoma 1 (2%)
C-Cell, Adenoma 3 (6%) 4 (8%) 2 (4%)
Follicular Cell, Adenoma 1 (2%)
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NTP Experiment-Test: 91014-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/14/97
Route: SKIN APPLICATION Time: 13:31:08
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 50 MG/KG 100MG/KG
____________________________________________________________________________________________________________________________________
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
Sarcoma 1 (100%)
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GENITAL SYSTEM
Clitoral Gland (49) (47) (50)
Adenoma 9 (18%) 3 (6%) 4 (8%)
Carcinoma 1 (2%) 1 (2%)
Schwannoma Malignant 1 (2%)
Bilateral, Adenoma 1 (2%)
Ovary (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Sarcoma 1 (2%)
Uterus (50) (50) (50)
Adenoma 1 (2%)
Deciduoma Benign 1 (2%)
Polyp Stromal 1 (2%) 2 (4%) 2 (4%)
Vagina (1) (1)
Polyp 1 (100%)
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HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Lymph Node (2) (2) (1)
Lymph Node, Mandibular (49) (49) (49)
Histiocytic Sarcoma 1 (2%)
Lymph Node, Mesenteric (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Spleen (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Thymus (47) (46) (50)
Histiocytic Sarcoma 1 (2%)
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INTEGUMENTARY SYSTEM
Mammary Gland (49) (49) (50)
Adenoma 1 (2%)
Carcinoma 1 (2%) 3 (6%)
Fibroadenoma 9 (18%) 10 (20%) 6 (12%)
Mixed Tumor Malignant 1 (2%)
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NTP Experiment-Test: 91014-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/14/97
Route: SKIN APPLICATION Time: 13:31:08
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 50 MG/KG 100MG/KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont
Skin (50) (50) (50)
Melanoma Malignant 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%)
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MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50)
Osteosarcoma 1 (2%)
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NERVOUS SYSTEM
Brain (50) (50) (50)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Adenoma 1 (2%)
Alveolar/Bronchiolar Adenoma 1 (2%) 1 (2%)
Chordoma, Metastatic, Uncertain Primary Site 1 (2%)
Histiocytic Sarcoma 1 (2%)
Squamous Cell Carcinoma 1 (2%)
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SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
Kidney (50) (50) (50)
Lipoma 1 (2%)
Renal Tubule, Adenoma, Multiple 1 (2%)
Urinary Bladder (50) (49) (49)
Transitional Epithelium, Carcinoma 1 (2%)
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SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%)
Leukemia Mononuclear 5 (10%) 9 (18%) 8 (16%)
Lymphoma Malignant 1 (2%)
* Number of animals with any tissue examined microscopically
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NTP Experiment-Test: 91014-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/14/97
Route: SKIN APPLICATION Time: 13:31:08
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 50 MG/KG 100MG/KG
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont
Multiple Organs *(50) *(50) *(50)
____________________________________________________________________________________________________________________________________
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NTP Experiment-Test: 91014-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/14/97
Route: SKIN APPLICATION Time: 13:31:08
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 50 MG/KG 100MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 40 34 32
Total Primary Neoplasms 70 61 51
Total Animals with Benign Neoplasms 38 28 26
Total Benign Neoplasms 58 45 39
Total Animals with Malignant Neoplasms 12 15 12
Total Malignant Neoplasms 12 16 12
Total Animals with Metastatic Neoplasms 1
Total Metastatic Neoplasm 1
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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NTP Experiment-Test: 91014-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/14/97
Route: SKIN APPLICATION Time: 13:31:08
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 50 MG/KG 100MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50
Early Deaths
Natural Death 16 10 12
Moribund Sacrifice 26 30 24
Survivors
Terminal Sacrifice 8 10 14
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (38) (41) (40)
Intestine Small, Duodenum (50) (50) (50)
Intestine Small, Jejunum (42) (45) (43)
Carcinoma 1 (2%)
Leiomyosarcoma 1 (2%)
Intestine Small, Ileum (41) (45) (45)
Liver (50) (50) (50)
Hepatocellular Carcinoma 1 (2%)
Hepatocellular Adenoma 1 (2%)
Mesentery (5) (7) (3)
Oral Mucosa (1)
Squamous Cell Papilloma 1 (100%)
Pancreas (50) (50) (50)
Acinus, Adenoma 1 (2%)
Salivary Glands (50) (50) (50)
Carcinoma 1 (2%)
Stomach, Forestomach (50) (50) (50)
Squamous Cell Carcinoma 1 (2%)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (50) (49) (50)
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CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50) (50)
Heart (50) (49) (50)
____________________________________________________________________________________________________________________________________
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NTP Experiment-Test: 91014-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/14/97
Route: SKIN APPLICATION Time: 13:31:08
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 50 MG/KG 100MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50)
Adrenal Medulla (50) (50) (49)
Pheochromocytoma Complex 1 (2%)
Pheochromocytoma Benign 8 (16%) 3 (6%) 3 (6%)
Bilateral, Pheochromocytoma Benign 4 (8%) 3 (6%) 3 (6%)
Islets, Pancreatic (50) (50) (50)
Adenoma 1 (2%) 3 (6%)
Carcinoma 2 (4%) 1 (2%) 1 (2%)
Pituitary Gland (50) (50) (49)
Pars Distalis, Adenoma 37 (74%) 38 (76%) 39 (80%)
Pars Distalis, Adenoma, Multiple 1 (2%) 1 (2%)
Thyroid Gland (50) (50) (50)
Bilateral, C-Cell, Adenoma 1 (2%)
C-Cell, Adenoma 2 (4%) 5 (10%) 6 (12%)
C-Cell, Carcinoma 2 (4%) 1 (2%) 1 (2%)
Follicular Cell, Adenoma 4 (8%) 1 (2%)
Follicular Cell, Carcinoma 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Epididymis (50) (50) (50)
Preputial Gland (50) (50) (50)
Adenoma 1 (2%) 1 (2%)
Carcinoma 1 (2%)
Prostate (50) (50) (50)
Seminal Vesicle (50) (50) (50)
Testes (50) (50) (50)
Bilateral, Interstitial Cell, Adenoma 14 (28%) 16 (32%) 21 (42%)
Interstitial Cell, Adenoma 10 (20%) 14 (28%) 16 (32%)
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HEMATOPOIETIC SYSTEM
Bone Marrow (50) (49) (50)
Lymph Node (2)
Lymph Node, Mandibular (49) (49) (49)
Lymph Node, Mesenteric (49) (48) (50)
Spleen (50) (50) (50)
Thymus (45) (42) (44)
____________________________________________________________________________________________________________________________________
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NTP Experiment-Test: 91014-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/14/97
Route: SKIN APPLICATION Time: 13:31:08
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 50 MG/KG 100MG/KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (49) (49) (49)
Carcinoma 1 (2%)
Fibroadenoma 3 (6%) 1 (2%)
Skin (50) (50) (50)
Basal Cell Adenoma 1 (2%)
Hemangiosarcoma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Keratoacanthoma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Lipoma 1 (2%)
Subcutaneous Tissue, Skin, Site of
Application, Fibroma 1 (2%)
Subcutaneous Tissue, Skin, Site of
Application, Fibrosarcoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (49) (50)
Vertebra, Chordoma 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50)
Alveolar/Bronchiolar Adenoma 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Hemangiosarcoma, Metastatic, Skin 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
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NTP Experiment-Test: 91014-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/14/97
Route: SKIN APPLICATION Time: 13:31:08
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 50 MG/KG 100MG/KG
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Renal Tubule, Adenoma 3 (6%) 4 (8%) 1 (2%)
Renal Tubule, Carcinoma 1 (2%)
Urinary Bladder (49) (50) (50)
Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%)
Leukemia Granulocytic 1 (2%)
Leukemia Mononuclear 14 (28%) 13 (26%) 13 (26%)
Lymphoma Malignant 1 (2%) 1 (2%)
Mesothelioma Malignant 2 (4%) 1 (2%) 3 (6%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
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NTP Experiment-Test: 91014-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 11/14/97
Route: SKIN APPLICATION Time: 13:31:08
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 50 MG/KG 100MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 49 48 50
Total Primary Neoplasms 117 114 127
Total Animals with Benign Neoplasms 47 47 49
Total Benign Neoplasms 90 91 99
Total Animals with Malignant Neoplasms 21 18 22
Total Malignant Neoplasms 27 23 28
Total Animals with Metastatic Neoplasms 1
Total Metastatic Neoplasm 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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