Nonneoplastic Lesions By Individual Animal
NTP Experiment-Test: 91014-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 09/23/97 Route: SKIN APPLICATION Time: 09:37:41 14 WEEK SSAC Facility: Battelle Columbus Laboratory Chemical CAS #: 93-83-4 Lock Date: 01/02/96 Cage Range: All Reasons For Removal: 25017 Scheduled Sacrifice Removal Date Range: All Treatment Groups: Include 002 0 MG/KG Include 004 15 MG/KG Include 006 30 MG/KG Include 001 0 MG/KG Include 003 15 MG/KG Include 005 30 MG/KG Page 1 NTP Experiment-Test: 91014-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 09/23/97 Route: SKIN APPLICATION Time: 09:37:41 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| | | | 4| 4| 4| 4| 4| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 2| 2| | A | 0 MG/KG | 9| 9| 9| 0| 1| | L | | 4| 8| 9| 0| 8| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Ovary | + | 1 | Follicle, Cyst | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Skin | + + + + + | 5 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 2 NTP Experiment-Test: 91014-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 09/23/97 Route: SKIN APPLICATION Time: 09:37:41 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| | | | 4| 4| 4| 4| 4| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| | A | 15 MG/KG | 3| 4| 6| 6| 7| | L | | 7| 2| 3| 4| 4| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Skin | + + + + + | 5 | Dermis, Skin, Site of Application, | | | Inflammation, Chronic Active | 1 1 1 1 | 4 1.0| Epidermis, Skin, Site of Application,| | | Hyperplasia | 1 1 1 1 1 | 5 1.0| Sebaceous Gland, Skin, Site of | | | Application, Hyperplasia | 1 1 1 1 1 | 5 1.0| Skin, Site of Application, | | | Hyperkeratosis | 1 1 | 2 1.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 3 NTP Experiment-Test: 91014-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 09/23/97 Route: SKIN APPLICATION Time: 09:37:41 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| | | | 4| 4| 4| 4| 4| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 2| 2| 2| | A | 15 MG/KG | 3| 4| 6| 6| 7| | L | | 7| 2| 3| 4| 4| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 4 NTP Experiment-Test: 91014-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 09/23/97 Route: SKIN APPLICATION Time: 09:37:41 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| | | | 4| 4| 4| 4| 4| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 3| 3| 3| | A | 30 MG/KG | 8| 8| 0| 1| 2| | L | | 7| 9| 4| 5| 8| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | + | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Skin | + + + + + | 5 | Dermis, Skin, Site of Application, | | | Inflammation, Chronic Active | 1 1 1 1 | 4 1.0| Epidermis, Skin, Site of Application,| | | Hyperplasia | 1 1 1 1 | 4 1.0| Sebaceous Gland, Skin, Site of | | | Application, Hyperplasia | 1 1 1 1 1 | 5 1.0| Skin, Site of Application, | | | Hyperkeratosis | 1 1 1 | 3 1.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 5 NTP Experiment-Test: 91014-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 09/23/97 Route: SKIN APPLICATION Time: 09:37:41 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| | | | 4| 4| 4| 4| 4| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 2| 2| 3| 3| 3| | A | 30 MG/KG | 8| 8| 0| 1| 2| | L | | 7| 9| 4| 5| 8| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 6 NTP Experiment-Test: 91014-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 09/23/97 Route: SKIN APPLICATION Time: 09:37:41 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| | | | 4| 4| 4| 4| 4| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| | A | 0 MG/KG | 0| 1| 2| 4| 4| | L | | 2| 8| 6| 0| 4| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Skin | + + + + + | 5 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 7 NTP Experiment-Test: 91014-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 09/23/97 Route: SKIN APPLICATION Time: 09:37:41 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| | | | 4| 4| 4| 4| 4| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| | A | 15 MG/KG | 6| 7| 8| 9| 9| | L | | 2| 0| 4| 3| 6| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Skin | + + + + + | 5 | Dermis, Skin, Site of Application, | | | Inflammation, Chronic Active | 1 1 1 1 1 | 5 1.0| Epidermis, Skin, Site of Application,| | | Hyperplasia | 1 1 2 1 1 | 5 1.2| Epidermis, Skin, Site of Application,| | | Parakeratosis | 1 | 1 1.0| Sebaceous Gland, Skin, Site of | | | Application, Hyperplasia | 1 1 1 1 1 | 5 1.0| Skin, Site of Application, | | | Hyperkeratosis | 1 1 1 1 | 4 1.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 8 NTP Experiment-Test: 91014-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 09/23/97 Route: SKIN APPLICATION Time: 09:37:41 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| | | | 4| 4| 4| 4| 4| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 0| 0| 0| 0| 0| | A | 15 MG/KG | 6| 7| 8| 9| 9| | L | | 2| 0| 4| 3| 6| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 9 NTP Experiment-Test: 91014-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 09/23/97 Route: SKIN APPLICATION Time: 09:37:41 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| | | | 4| 4| 4| 4| 4| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| | A | 30 MG/KG | 3| 3| 5| 6| 6| | L | | 2| 3| 9| 2| 3| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Skin | + + + + + | 5 | Dermis, Skin, Site of Application, | | | Inflammation, Chronic Active | 2 1 2 2 1 | 5 1.6| Epidermis, Skin, Site of Application,| | | Hyperplasia | 2 2 2 2 2 | 5 2.0| Epidermis, Skin, Site of Application,| | | Inflammation, Suppurative | 1 | 1 1.0| Epidermis, Skin, Site of Application,| | | Parakeratosis | 1 1 1 1 | 4 1.0| Sebaceous Gland, Skin, Site of | | | Application, Hyperplasia | 1 1 1 1 1 | 5 1.0| Skin, Site of Application, | | | Hyperkeratosis | 1 1 1 1 | 4 1.0| Skin, Site of Application, Ulcer | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | None | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 10 NTP Experiment-Test: 91014-04 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: CHRONIC OLEIC ACID DIETHANOLAMINE CONDENSATE Date: 09/23/97 Route: SKIN APPLICATION Time: 09:37:41 __________________________________________________________________________________________________________________________________ | 0| 0| 0| 0| 0| | | DAY ON TEST | 9| 9| 9| 9| 9| | | | 4| 4| 4| 4| 4| | T (*) | _____________________________________________________________________________________________________________________| | | 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| | T | ANIMAL ID | 1| 1| 1| 1| 1| | A | 30 MG/KG | 3| 3| 5| 6| 6| | L | | 2| 3| 9| 2| 3| | | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 11 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------