TDMS Study 93026-06 Pathology Tables
NTP Experiment-Test: 93026-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DECALIN Date: 04/11/02
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:02
Final#1, Revision#2
Facility: Battelle Northwest
Chemical CAS #: 91-17-8
Lock Date: 01/04/01
Cage Range: All
Reasons For Removal: 25022 Accidently Killed 25019 Moribund Sacrifice
25020 Natural Death 25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 93026-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DECALIN Date: 04/11/02
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 25 PPM 100 PPM 400 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Natural Death 2 7 3 6
Moribund Sacrifice 10 15 11 8
Accidently Killed 1
Survivors
Moribund Sacrifice 1
Terminal Sacrifice 37 28 35 35
Animals Examined Microscopically 49 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (49) (50) (50) (50)
Hyperplasia, Squamous 1 (2%)
Inflammation, Chronic Active 2 (4%)
Intestine Large, Rectum (49) (47) (49) (48)
Necrosis 1 (2%)
Intestine Small, Duodenum (48) (43) (47) (47)
Inflammation, Acute 1 (2%)
Necrosis 1 (2%) 1 (2%)
Intestine Small, Jejunum (48) (45) (48) (45)
Infiltration Cellular, Mixed Cell 1 (2%)
Necrosis 1 (2%)
Intestine Small, Ileum (47) (45) (49) (47)
Infiltration Cellular, Mixed Cell 2 (4%)
Inflammation, Granulomatous 1 (2%)
Necrosis 1 (2%)
Liver (49) (50) (50) (50)
Angiectasis 1 (2%) 1 (2%) 1 (2%)
Basophilic Focus 8 (16%) 7 (14%) 6 (12%) 3 (6%)
Clear Cell Focus 2 (4%) 2 (4%) 4 (8%) 1 (2%)
Cyst 1 (2%)
Eosinophilic Focus 8 (16%) 6 (12%) 11 (22%) 11 (22%)
Fatty Change 2 (4%) 2 (4%) 2 (4%)
Hematopoietic Cell Proliferation 2 (4%) 3 (6%)
Infarct 1 (2%) 2 (4%)
Infiltration Cellular, Mast Cell 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%)
Inflammation, Granulomatous 16 (33%) 11 (22%) 16 (32%) 16 (32%)
Mitotic Alteration 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 93026-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DECALIN Date: 04/11/02
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 25 PPM 100 PPM 400 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Mixed Cell Focus 1 (2%)
Necrosis 1 (2%) 1 (2%)
Tension Lipidosis 3 (6%) 4 (8%)
Thrombosis 1 (2%)
Vacuolization Cytoplasmic 1 (2%) 1 (2%)
Bile Duct, Cyst 1 (2%)
Centrilobular, Degeneration 1 (2%)
Centrilobular, Necrosis 1 (2%) 2 (4%)
Oval Cell, Hyperplasia 1 (2%)
Mesentery (17) (18) (12) (18)
Inflammation, Granulomatous 2 (12%) 2 (11%)
Thrombosis 1 (6%)
Fat, Hemorrhage 1 (6%)
Fat, Necrosis 16 (94%) 16 (89%) 11 (92%) 16 (89%)
Pancreas (49) (47) (50) (49)
Angiectasis 1 (2%)
Atrophy 1 (2%) 1 (2%)
Basophilic Focus 1 (2%) 1 (2%)
Lipomatosis 1 (2%)
Necrosis 1 (2%)
Salivary Glands (49) (50) (50) (50)
Degeneration 1 (2%)
Stomach, Forestomach (49) (49) (50) (47)
Hyperplasia, Squamous 5 (10%) 1 (2%) 6 (12%) 2 (4%)
Inflammation, Acute 1 (2%) 1 (2%) 2 (4%)
Stomach, Glandular (48) (47) (50) (47)
Infiltration Cellular, Mixed Cell 1 (2%)
Mineralization 2 (4%) 3 (6%) 1 (2%)
Necrosis 1 (2%) 1 (2%)
Tooth (4) (2) (1) (1)
Inflammation, Chronic Active 1 (50%)
Malformation 3 (75%) 1 (50%) 1 (100%) 1 (100%)
Dentine, Incisor, Dysplasia 1 (25%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (2)
Aorta, Mineralization 1 (50%)
Heart (49) (50) (50) (50)
Cardiomyopathy 8 (16%) 10 (20%) 13 (26%) 8 (16%)
Inflammation, Chronic Active 1 (2%)
Mineralization 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 93026-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DECALIN Date: 04/11/02
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 25 PPM 100 PPM 400 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - CONT
Atrium, Inflammation, Acute 1 (2%)
Atrium, Thrombosis 1 (2%)
Capillary, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (50) (50) (49)
Hyperplasia 6 (12%) 7 (14%) 5 (10%) 5 (10%)
Hypertrophy 3 (6%) 8 (16%) 2 (4%) 6 (12%)
Necrosis 1 (2%)
Thrombosis 1 (2%)
Vacuolization Cytoplasmic 1 (2%)
Subcapsular, Hyperplasia 1 (2%) 1 (2%)
Adrenal Medulla (48) (50) (50) (49)
Hyperplasia 1 (2%) 2 (4%) 2 (4%) 2 (4%)
Islets, Pancreatic (49) (47) (50) (49)
Hyperplasia 1 (2%)
Pituitary Gland (49) (49) (49) (50)
Pars Distalis, Angiectasis 1 (2%) 1 (2%)
Pars Distalis, Hyperplasia 20 (41%) 20 (41%) 20 (41%) 12 (24%)
Pars Intermedia, Hyperplasia 2 (4%)
Pars Intermedia, Hypertrophy 1 (2%) 1 (2%)
Thyroid Gland (49) (49) (50) (47)
Cyst 1 (2%)
Follicular Cell, Hyperplasia 1 (2%) 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (49) (49) (49) (48)
Angiectasis 2 (4%) 1 (2%) 1 (2%)
Cyst 16 (33%) 11 (22%) 8 (16%) 10 (21%)
Hyperplasia, Tubular 1 (2%) 1 (2%) 1 (2%)
Inflammation, Granulomatous 1 (2%)
Thrombosis 1 (2%)
Uterus (49) (49) (50) (49)
Angiectasis 1 (2%) 2 (4%) 2 (4%) 3 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 93026-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DECALIN Date: 04/11/02
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 25 PPM 100 PPM 400 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Hyperplasia, Cystic 3 (6%) 3 (6%) 5 (10%)
Inflammation, Suppurative 1 (2%)
Necrosis 1 (2%)
Thrombosis 1 (2%)
Endometrium, Hyperplasia, Cystic 7 (14%) 5 (10%) 4 (8%) 8 (16%)
Lymphatic, Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (5) (2) (4) (1)
Lumbar, Angiectasis 1 (25%)
Renal, Angiectasis 2 (40%)
Lymph Node, Bronchial (41) (45) (47) (44)
Infiltration Cellular, Plasma Cell 1 (2%) 1 (2%)
Lymph Node, Mandibular (36) (40) (37) (41)
Hyperplasia, Lymphoid 1 (3%)
Infiltration Cellular, Mast Cell 1 (3%)
Lymph Node, Mesenteric (47) (47) (50) (47)
Angiectasis 1 (2%) 2 (4%) 2 (4%)
Ectasia 1 (2%)
Infiltration Cellular, Plasma Cell 1 (2%) 1 (2%)
Inflammation, Granulomatous 1 (2%) 1 (2%)
Lymph Node, Mediastinal (43) (42) (43) (46)
Congestion 1 (2%)
Infiltration Cellular, Plasma Cell 1 (2%)
Spleen (49) (47) (50) (48)
Hematopoietic Cell Proliferation 1 (2%) 2 (4%) 2 (4%) 3 (6%)
Hyperplasia, Lymphoid 1 (2%) 2 (4%) 1 (2%)
Infiltration Cellular, Mast Cell 1 (2%)
Necrosis 1 (2%)
Thymus (48) (48) (48) (47)
Necrosis 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (50) (50) (50)
Hyperplasia 2 (4%) 1 (2%) 1 (2%)
Skin (49) (50) (50) (50)
Hyperplasia, Basal Cell 1 (2%)
Infiltration Cellular, Mixed Cell 1 (2%) 2 (4%) 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 93026-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DECALIN Date: 04/11/02
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 25 PPM 100 PPM 400 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Inflammation, Granulomatous 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (49) (50) (50) (50)
Fibrous Osteodystrophy 3 (6%) 3 (6%) 2 (4%) 2 (4%)
Skeletal Muscle (2)
Necrosis, Fatty 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (50) (50) (50)
Meninges, Infiltration Cellular, Mononuclear
Cell 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (49) (50) (50) (49)
Inflammation, Acute 1 (2%)
Mineralization 1 (2%)
Lung (49) (50) (50) (50)
Congestion 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Inflammation, Granulomatous 3 (6%)
Mineralization 1 (2%)
Thrombosis 1 (2%)
Alveolar Epithelium, Hyperplasia 4 (8%) 2 (4%) 3 (6%) 4 (8%)
Alveolus, Infiltration Cellular, Histiocyte 3 (6%) 1 (2%) 3 (6%)
Artery, Inflammation, Chronic 1 (2%)
Bronchiole, Hyperplasia 1 (2%) 1 (2%)
Nose (49) (50) (50) (49)
Inflammation, Suppurative 3 (6%) 1 (2%) 1 (2%)
Glands, Dilatation 1 (2%) 5 (10%)
Olfactory Epithelium, Atrophy 1 (2%) 2 (4%)
Respiratory Epithelium, Metaplasia, Squamous 1 (2%)
Sinus, Foreign Body 1 (2%) 1 (2%)
Trachea (49) (49) (50) (49)
Inflammation, Acute 1 (2%)
Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 93026-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DECALIN Date: 04/11/02
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 25 PPM 100 PPM 400 PPM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (1) (2)
Cornea, Inflammation, Chronic Active 1 (50%) 1 (100%) 1 (50%)
Harderian Gland (4) (4) (5) (3)
Hyperplasia 1 (33%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (50) (50) (50)
Amyloid Deposition 1 (2%) 1 (2%)
Infarct 4 (8%) 2 (4%)
Metaplasia, Osseous 4 (8%) 1 (2%) 1 (2%) 3 (6%)
Nephropathy 45 (92%) 40 (80%) 40 (80%) 41 (82%)
Pelvis, Dilatation 1 (2%)
Renal Tubule, Hyperplasia 1 (2%)
Renal Tubule, Necrosis 1 (2%)
Renal Tubule, Vacuolization Cytoplasmic 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 93026-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DECALIN Date: 04/11/02
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 25 PPM 100 PPM 400 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 7 7 7 5
Natural Death 3 2 7 11
Survivors
Terminal Sacrifice 39 41 35 33
Moribund Sacrifice 1
Natural Death 1 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (42) (40) (41) (40)
Degeneration, Hyaline 1 (2%) 3 (8%)
Hyperplasia 1 (3%) 1 (3%)
Intestine Large, Colon (49) (48) (49) (49)
Hemorrhage 1 (2%)
Infiltration Cellular, Mixed Cell 1 (2%)
Necrosis 1 (2%)
Serosa, Inflammation, Chronic 1 (2%)
Intestine Large, Cecum (48) (48) (49) (46)
Hemorrhage 1 (2%)
Infiltration Cellular, Mixed Cell 1 (2%)
Inflammation, Acute 1 (2%)
Necrosis 1 (2%)
Serosa, Inflammation, Granulomatous 1 (2%)
Intestine Small, Duodenum (47) (48) (47) (43)
Inflammation, Acute 1 (2%)
Necrosis 1 (2%)
Intestine Small, Jejunum (46) (48) (47) (43)
Infiltration Cellular, Mixed Cell 1 (2%) 1 (2%)
Necrosis 1 (2%)
Intestine Small, Ileum (46) (48) (47) (46)
Hyperplasia 1 (2%)
Infiltration Cellular, Mixed Cell 1 (2%) 1 (2%)
Liver (50) (50) (50) (50)
Angiectasis 1 (2%) 1 (2%)
Basophilic Focus 9 (18%) 6 (12%) 13 (26%) 13 (26%)
Clear Cell Focus 17 (34%) 21 (42%) 16 (32%) 21 (42%)
Eosinophilic Focus 10 (20%) 9 (18%) 7 (14%) 19 (38%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 93026-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DECALIN Date: 04/11/02
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 25 PPM 100 PPM 400 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Erythrophagocytosis 9 (18%)
Fatty Change 1 (2%) 3 (6%) 3 (6%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Infarct 1 (2%)
Inflammation, Granulomatous 5 (10%) 6 (12%) 9 (18%) 3 (6%)
Mixed Cell Focus 1 (2%)
Necrosis 1 (2%) 3 (6%) 19 (38%)
Syncytial Alteration 26 (52%) 28 (56%) 36 (72%) 44 (88%)
Tension Lipidosis 2 (4%) 5 (10%) 1 (2%)
Thrombosis 1 (2%)
Vacuolization Cytoplasmic 1 (2%)
Bile Duct, Degeneration, Hyaline 1 (2%)
Centrilobular, Hypertrophy 2 (4%) 4 (8%) 36 (72%)
Centrilobular, Necrosis 4 (8%) 2 (4%)
Mesentery (14) (11) (10) (15)
Inflammation, Granulomatous 3 (21%) 1 (9%) 2 (20%) 3 (20%)
Artery, Inflammation, Chronic Active 1 (9%)
Fat, Necrosis 12 (86%) 9 (82%) 9 (90%) 12 (80%)
Pancreas (49) (50) (50) (49)
Atrophy 1 (2%) 1 (2%)
Basophilic Focus 1 (2%) 1 (2%)
Cyst 1 (2%)
Lipomatosis 1 (2%) 1 (2%)
Stomach, Forestomach (49) (50) (49) (50)
Hyperplasia, Squamous 4 (8%) 4 (8%) 1 (2%) 9 (18%)
Inflammation, Acute 2 (4%) 1 (2%) 1 (2%) 4 (8%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Necrosis 1 (2%) 1 (2%) 4 (8%)
Stomach, Glandular (49) (49) (48) (48)
Hyperplasia 1 (2%)
Infiltration Cellular, Mixed Cell 1 (2%)
Mineralization 1 (2%) 1 (2%)
Necrosis 2 (4%)
Tooth (23) (26) (22) (21)
Inflammation, Chronic Active 1 (4%)
Malformation 21 (91%) 26 (100%) 22 (100%) 20 (95%)
Dentine, Incisor, Dysplasia 1 (4%) 1 (5%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1) (3) (1)
Inflammation, Chronic Active 1 (100%) 1 (33%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 93026-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DECALIN Date: 04/11/02
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 25 PPM 100 PPM 400 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - CONT
Heart (50) (50) (50) (50)
Angiectasis 1 (2%)
Cardiomyopathy 9 (18%) 8 (16%) 7 (14%) 7 (14%)
Mineralization 1 (2%) 1 (2%)
Artery, Inflammation, Chronic Active 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (50) (50) (50)
Hyperplasia 23 (47%) 16 (32%) 13 (26%) 14 (28%)
Hypertrophy 37 (76%) 42 (84%) 30 (60%) 26 (52%)
Subcapsular, Hyperplasia 1 (2%)
Adrenal Medulla (49) (50) (50) (50)
Hyperplasia 3 (6%) 3 (6%)
Islets, Pancreatic (49) (50) (50) (49)
Hypertrophy 2 (4%)
Pituitary Gland (48) (50) (50) (49)
Cyst 1 (2%) 1 (2%)
Pars Distalis, Hyperplasia 2 (4%) 1 (2%) 3 (6%) 3 (6%)
Pars Intermedia, Hyperplasia 1 (2%)
Pars Intermedia, Hypertrophy 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Granuloma Sperm 1 (2%) 2 (4%) 1 (2%) 3 (6%)
Inflammation, Chronic 1 (2%)
Preputial Gland (49) (49) (50) (50)
Ectasia 28 (57%) 24 (49%) 21 (42%) 22 (44%)
Hyperplasia, Squamous 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%) 2 (4%) 2 (4%)
Prostate (48) (50) (50) (50)
Hyperplasia 2 (4%)
Inflammation, Chronic Active 2 (4%)
Artery, Inflammation, Chronic Active 1 (2%)
Seminal Vesicle (49) (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 93026-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DECALIN Date: 04/11/02
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 25 PPM 100 PPM 400 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Inflammation, Chronic 1 (2%)
Testes (50) (50) (50) (50)
Mineralization 1 (2%) 1 (2%)
Interstitial Cell, Hyperplasia 2 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (50) (50) (48)
Angiectasis 1 (2%)
Thrombosis 1 (2%)
Lymph Node (1) (3) (1)
Iliac, Infiltration Cellular, Plasma Cell 1 (33%) 1 (100%)
Lymph Node, Mesenteric (49) (48) (50) (47)
Angiectasis 2 (4%)
Infiltration Cellular, Plasma Cell 2 (4%) 1 (2%) 2 (4%)
Infiltration Cellular, Mixed Cell 2 (4%) 1 (2%)
Lymph Node, Mediastinal (41) (36) (42) (35)
Inflammation, Granulomatous 1 (2%)
Spleen (49) (50) (50) (49)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%) 2 (4%) 2 (4%)
Hyperplasia, Lymphoid 1 (2%)
Thymus (44) (44) (42) (40)
Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (50) (50)
Cyst Epithelial Inclusion 1 (2%)
Hyperplasia, Basal Cell 1 (2%)
Infiltration Cellular, Mixed Cell 1 (2%)
Inflammation, Acute 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%) 2 (4%) 2 (4%) 4 (8%)
Lymphatic, Angiectasis 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 93026-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DECALIN Date: 04/11/02
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 25 PPM 100 PPM 400 PPM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Meninges, Infiltration Cellular, Mononuclear
Cell 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (50) (50) (50)
Degeneration, Hyaline 1 (2%)
Inflammation, Acute 1 (2%)
Lung (50) (50) (50) (50)
Inflammation, Granulomatous 3 (6%) 2 (4%) 1 (2%)
Thrombosis 1 (2%)
Alveolar Epithelium, Hyperplasia 5 (10%) 2 (4%) 2 (4%) 6 (12%)
Alveolus, Infiltration Cellular, Histiocyte 1 (2%) 2 (4%)
Nose (50) (50) (50) (48)
Inflammation, Suppurative 1 (2%) 2 (4%) 4 (8%) 2 (4%)
Polyp, Inflammatory 1 (2%)
Thrombosis 2 (4%)
Glands, Dilatation 2 (4%) 2 (4%) 1 (2%) 3 (6%)
Olfactory Epithelium, Atrophy 1 (2%) 1 (2%) 3 (6%)
Sinus, Foreign Body 1 (2%)
Trachea (49) (50) (49) (48)
Degeneration, Hyaline 1 (2%)
Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (3) (3) (2) (1)
Cataract 2 (67%)
Degeneration 1 (33%)
Cornea, Inflammation, Chronic Active 1 (33%)
Harderian Gland (9) (5) (5) (5)
Hyperplasia 1 (11%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (50) (50) (49)
Cyst 1 (2%)
Infarct 3 (6%) 2 (4%) 5 (10%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 93026-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DECALIN Date: 04/11/02
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 09:16:02
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 25 PPM 100 PPM 400 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Metaplasia, Osseous 3 (6%) 3 (6%) 5 (10%) 2 (4%)
Mineralization 1 (2%)
Nephropathy 47 (96%) 46 (92%) 47 (94%) 41 (84%)
Renal Tubule, Hyperplasia 1 (2%) 2 (4%)
Renal Tubule, Karyomegaly 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
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