TDMS Study 93026-07 Pathology Tables
NTP Experiment-Test: 93026-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DECALIN Date: 09/26/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:32:26
FINAL/RATS
Facility: Battelle Northwest
Chemical CAS #: 91-17-8
Lock Date: 05/31/00
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 93026-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DECALIN Date: 09/26/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:32:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 25 PPM 100 PPM 400 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 16 10 10 17
Natural Death 2 5 5
Accidently Killed 1
Survivors
Moribund Sacrifice 1
Terminal Sacrifice 32 35 38 28
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Jejunum (48) (46) (49) (45)
Muscularis, Inflammation, Chronic 1 (2%)
Liver (50) (48) (49) (50)
Angiectasis 1 (2%) 2 (4%) 1 (2%)
Basophilic Focus 2 (4%) 1 (2%)
Clear Cell Focus 7 (14%) 5 (10%) 4 (8%) 2 (4%)
Congestion 1 (2%) 1 (2%)
Hepatodiaphragmatic Nodule 9 (18%) 6 (13%) 6 (12%) 7 (14%)
Inflammation, Granulomatous 1 (2%)
Necrosis 2 (4%) 2 (4%)
Vacuolization Cytoplasmic 3 (6%) 2 (4%)
Bile Duct, Hyperplasia 1 (2%)
Hepatocyte, Regeneration 1 (2%)
Periportal, Pigmentation 1 (2%)
Serosa, Hemorrhage 1 (2%)
Mesentery (26) (20) (20) (17)
Necrosis 26 (100%) 20 (100%) 20 (100%) 16 (94%)
Oral Mucosa (1) (2)
Inflammation, Chronic 1 (100%)
Pharyngeal, Hyperplasia, Squamous 2 (100%)
Pancreas (50) (47) (49) (49)
Acinus, Atrophy 1 (2%) 1 (2%)
Stomach, Forestomach (50) (47) (49) (49)
Erosion 1 (2%)
Hyperplasia, Squamous 1 (2%) 1 (2%) 1 (2%)
Mineralization 1 (2%)
Ulcer 2 (4%) 2 (4%) 1 (2%)
Stomach, Glandular (50) (47) (49) (49)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 93026-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DECALIN Date: 09/26/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:32:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 25 PPM 100 PPM 400 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Mineralization 1 (2%)
Tongue (2) (1)
Epithelium, Hyperplasia 1 (100%)
Tooth (1)
Pulp, Inflammation, Suppurative 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (49) (50)
Cardiomyopathy 1 (2%) 1 (2%)
Artery, Mineralization 1 (2%)
Atrium, Thrombosis 2 (4%) 2 (4%) 1 (2%)
Ventricle, Angiectasis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (48) (49) (49)
Hyperplasia 3 (6%) 2 (4%) 2 (4%)
Hypertrophy 1 (2%)
Necrosis 1 (2%)
Vacuolization Cytoplasmic 7 (14%) 7 (15%) 11 (22%) 8 (16%)
Adrenal Medulla (50) (48) (49) (49)
Hyperplasia 3 (6%) 2 (4%)
Islets, Pancreatic (50) (47) (49) (49)
Hyperplasia 1 (2%)
Parathyroid Gland (49) (48) (48) (47)
Hyperplasia 1 (2%)
Pituitary Gland (50) (49) (49) (50)
Angiectasis 1 (2%)
Cyst 1 (2%) 4 (8%) 3 (6%)
Hemorrhage 1 (2%) 1 (2%)
Pars Distalis, Angiectasis 2 (4%)
Pars Distalis, Hyperplasia 7 (14%) 9 (18%) 8 (16%) 5 (10%)
Thyroid Gland (50) (49) (49) (50)
C-Cell, Hyperplasia 15 (30%) 7 (14%) 6 (12%) 6 (12%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 93026-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DECALIN Date: 09/26/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:32:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 25 PPM 100 PPM 400 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (48) (49) (49) (50)
Cyst 2 (4%) 3 (6%) 2 (4%) 1 (2%)
Hyperplasia 3 (6%) 3 (6%) 1 (2%) 3 (6%)
Inflammation, Chronic 1 (2%) 1 (2%)
Ovary (50) (50) (49) (50)
Cyst 3 (6%) 4 (8%) 6 (12%) 3 (6%)
Uterus (50) (49) (49) (50)
Atrophy 1 (2%)
Hemorrhage 1 (2%)
Endometrium, Hyperplasia 3 (6%) 1 (2%)
Endometrium, Inflammation, Suppurative 1 (2%)
Endometrium, Metaplasia, Squamous 1 (2%)
Vagina (1) (2)
Epithelium, Hyperplasia 1 (50%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (6) (4) (2)
Hyperplasia, Lymphoid 1 (17%)
Deep Cervical, Ectasia 1 (17%) 1 (50%)
Deep Cervical, Hyperplasia, Lymphoid 1 (25%)
Deep Cervical, Infiltration Cellular,
Histiocyte 1 (17%)
Deep Cervical, Pigmentation 1 (17%)
Pancreatic, Pigmentation 1 (25%)
Thoracic, Hyperplasia, Plasma Cell 1 (50%)
Lymph Node, Bronchial (2) (10) (7) (5)
Ectasia 1 (50%) 1 (10%)
Infiltration Cellular, Histiocyte 1 (14%)
Inflammation, Suppurative 1 (50%)
Pigmentation 2 (20%) 1 (20%)
Lymph Node, Mediastinal (45) (46) (49) (44)
Angiectasis 1 (2%) 2 (4%) 1 (2%)
Hyperplasia, Plasma Cell 1 (2%)
Inflammation, Suppurative 1 (2%)
Pigmentation 1 (2%)
Spleen (50) (49) (49) (50)
Accessory Spleen 1 (2%) 1 (2%) 1 (2%)
Fibrosis 1 (2%) 3 (6%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 93026-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DECALIN Date: 09/26/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:32:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 25 PPM 100 PPM 400 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hemorrhage 3 (6%)
Necrosis 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (49) (50)
Galactocele 3 (6%) 1 (2%) 5 (10%) 1 (2%)
Skin (50) (50) (49) (50)
Cyst Epithelial Inclusion 1 (2%)
Erosion 1 (2%)
Ulcer 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fracture 1 (2%)
Cranium, Hemorrhage 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (49) (49) (50)
Compression 6 (12%) 5 (10%) 6 (12%) 3 (6%)
Hemorrhage 1 (2%) 1 (2%) 3 (6%) 6 (12%)
Thrombosis 1 (2%)
Cerebrum, Gliosis 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (49) (49) (48)
Foreign Body 1 (2%) 3 (6%)
Inflammation, Chronic 2 (4%) 4 (8%) 2 (4%) 2 (4%)
Inflammation, Suppurative 2 (4%) 4 (8%)
Epiglottis, Metaplasia, Squamous 1 (2%) 1 (2%)
Respiratory Epithelium, Hyperplasia 1 (2%)
Respiratory Epithelium, Metaplasia, Squamous 1 (2%)
Respiratory Epithelium, Epiglottis,
Degeneration 1 (2%) 1 (2%)
Squamous Epithelium, Hyperplasia 1 (2%)
Lung (50) (50) (49) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 93026-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DECALIN Date: 09/26/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:32:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 25 PPM 100 PPM 400 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Congestion 1 (2%)
Foreign Body 1 (2%)
Alveolar Epithelium, Hyperplasia 9 (18%) 14 (28%) 8 (16%) 14 (28%)
Alveolar Epithelium, Metaplasia, Squamous 1 (2%) 2 (4%)
Alveolus, Infiltration Cellular, Histiocyte 21 (42%) 26 (52%) 29 (59%) 29 (58%)
Alveolus, Pigmentation 1 (2%)
Alveolus, Proteinosis 11 (22%) 16 (32%) 15 (31%) 23 (46%)
Bronchiole, Mineralization 1 (2%)
Interstitium, Fibrosis 16 (32%) 24 (48%) 23 (47%) 28 (56%)
Interstitium, Inflammation, Chronic 1 (2%) 6 (12%) 6 (12%) 4 (8%)
Mediastinum, Hyperplasia, Histiocytic 1 (2%)
Mediastinum, Pigmentation 1 (2%)
Perivascular, Pigmentation 1 (2%)
Nose (50) (48) (49) (49)
Foreign Body 1 (2%) 4 (8%) 3 (6%) 1 (2%)
Inflammation, Suppurative 3 (6%) 5 (10%) 7 (14%) 3 (6%)
Goblet Cell, Hyperplasia 1 (2%) 1 (2%) 5 (10%) 2 (4%)
Nasolacrimal Duct, Inflammation, Suppurative 3 (6%) 1 (2%) 1 (2%) 3 (6%)
Olfactory Epithelium, Degeneration, Hyaline 1 (2%)
Respiratory Epithelium, Hyperplasia 1 (2%) 1 (2%) 2 (4%)
Respiratory Epithelium, Metaplasia, Squamous 1 (2%) 2 (4%) 2 (4%) 1 (2%)
Pleura (20) (25) (25) (28)
Inflammation, Chronic 15 (75%) 17 (68%) 23 (92%) 27 (96%)
Mesothelium, Hyperplasia 2 (10%) 7 (28%) 8 (32%) 2 (7%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (2) (5) (4)
Atrophy 2 (100%)
Anterior Chamber, Hemorrhage 1 (25%)
Choroid, Sclera, Mineralization 1 (20%)
Cornea, Hyperplasia 1 (25%)
Cornea, Inflammation, Suppurative 1 (50%)
Lens, Cataract 1 (100%) 3 (60%) 2 (50%)
Harderian Gland (1)
Inflammation, Suppurative 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (46) (49) (50)
Cyst 1 (2%) 2 (4%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 93026-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DECALIN Date: 09/26/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:32:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 25 PPM 100 PPM 400 PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Cytoplasmic Alteration 1 (2%) 1 (2%)
Nephropathy, Chronic 44 (88%) 45 (98%) 48 (98%) 48 (96%)
Cortex, Renal Tubule, Hyperplasia 1 (2%) 4 (9%) 4 (8%) 2 (4%)
Papilla, Mineralization 3 (6%) 2 (4%) 4 (8%) 4 (8%)
Pelvis, Dilatation 1 (2%) 1 (2%) 1 (2%)
Pelvis, Mineralization 11 (22%) 16 (35%) 19 (39%) 18 (36%)
Pelvis, Transitional Epithelium, Hyperplasia 2 (4%) 2 (4%) 2 (4%)
Renal Tubule, Mineralization 1 (2%)
Renal Tubule, Pigmentation 1 (2%)
Ureter (1)
Mineralization 1 (100%)
Necrosis 1 (100%)
Urinary Bladder (50) (47) (49) (50)
Degeneration 1 (2%)
Necrosis 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 93026-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DECALIN Date: 09/26/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:32:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 25 PPM 50 PPM 100 PPM 400 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50 20
Early Deaths
Moribund Sacrifice 17 21 23 23 6
Natural Death 5 6 3 7
Survivors
Terminal Sacrifice 28 23 23 20 14
Other 1
Animals Examined Microscopically 50 50 49 50 20
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (48) (47) (48) (49) (20)
Ulcer 1 (2%)
Liver (50) (50) (49) (50) (20)
Angiectasis 1 (2%) 1 (5%)
Clear Cell Focus 2 (4%) 1 (2%) 3 (6%) 3 (6%)
Congestion 1 (2%)
Cyst 1 (2%) 1 (2%)
Degeneration, Cystic 1 (2%)
Hepatodiaphragmatic Nodule 7 (14%) 5 (10%) 7 (14%) 4 (8%) 4 (20%)
Infiltration Cellular, Lymphohistiocytic 2 (10%)
Mixed Cell Focus 3 (6%) 1 (2%)
Necrosis 1 (2%) 1 (2%) 2 (4%)
Thrombosis 1 (2%) 1 (2%)
Vacuolization Cytoplasmic 2 (4%) 1 (2%) 1 (2%)
Bile Duct, Hyperplasia 2 (4%) 1 (2%) 3 (15%)
Hepatocyte, Regeneration 2 (4%) 1 (2%) 4 (8%) 2 (4%) 1 (5%)
Mesentery (16) (19) (20) (13) (10)
Necrosis 7 (44%) 9 (47%) 12 (60%) 4 (31%) 2 (20%)
Artery, Inflammation 1 (10%)
Fat, Hemorrhage 2 (10%) 2 (20%)
Fat, Necrosis 9 (56%) 6 (32%) 6 (30%) 6 (46%) 5 (50%)
Oral Mucosa (2) (2) (1)
Inflammation, Chronic 1 (100%)
Pharyngeal, Hyperplasia, Squamous 1 (50%)
Pancreas (50) (50) (49) (50) (20)
Acinus, Atrophy 1 (2%) 2 (4%) 3 (6%) 2 (4%) 2 (10%)
Acinus, Hyperplasia 1 (2%)
Salivary Glands (50) (50) (49) (50) (20)
Inflammation, Suppurative 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 93026-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DECALIN Date: 09/26/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:32:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 25 PPM 50 PPM 100 PPM 400 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Stomach, Forestomach (50) (50) (49) (50) (20)
Erosion 1 (2%)
Hyperplasia, Squamous 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (5%)
Ulcer 5 (10%) 4 (8%) 3 (6%) 1 (5%)
Stomach, Glandular (50) (50) (49) (50) (20)
Erosion 1 (2%) 1 (2%)
Necrosis 1 (2%)
Ulcer 1 (2%) 2 (4%)
Tongue (1) (2) (1)
Inflammation 1 (50%)
Tooth (1) (1) (1)
Inflammation 1 (100%)
Peridontal Tissue, Inflammation 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (44) (50) (49) (45) (11)
Thrombosis 1 (9%)
Pulmonary Artery, Inflammation 1 (9%)
Heart (50) (50) (49) (50) (20)
Cardiomyopathy 5 (10%) 5 (10%) 4 (8%) 9 (18%) 3 (15%)
Atrium, Thrombosis 2 (4%) 2 (4%) 5 (10%) 2 (4%) 1 (5%)
Valve, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (49) (50) (20)
Hyperplasia 1 (2%) 1 (2%) 3 (6%)
Necrosis 1 (2%) 2 (4%)
Vacuolization Cytoplasmic 2 (4%) 6 (12%) 5 (10%) 2 (4%) 1 (5%)
Adrenal Medulla (49) (49) (49) (49) (20)
Hyperplasia 10 (20%) 13 (27%) 26 (53%) 17 (35%) 4 (20%)
Necrosis 1 (2%) 1 (2%)
Islets, Pancreatic (50) (50) (49) (50) (20)
Hyperplasia 1 (2%) 1 (2%)
Parathyroid Gland (49) (48) (49) (49) (20)
Hyperplasia 1 (2%)
Pituitary Gland (50) (50) (49) (49) (20)
Cyst 1 (2%) 1 (2%) 1 (2%) 1 (5%)
Hemorrhage 1 (2%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 93026-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DECALIN Date: 09/26/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:32:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 25 PPM 50 PPM 100 PPM 400 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Distalis, Hyperplasia 7 (14%) 4 (8%) 5 (10%) 6 (12%) 1 (5%)
Pars Intermedia, Hyperplasia 1 (2%)
Thyroid Gland (50) (50) (49) (49) (20)
C-Cell, Hyperplasia 6 (12%) 6 (12%) 6 (12%) 7 (35%)
Follicular Cell, Hyperplasia 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (49) (50) (20)
Spermatocele 1 (2%)
Preputial Gland (50) (49) (49) (50) (20)
Hyperplasia 1 (2%) 1 (2%) 2 (4%) 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%) 1 (2%)
Prostate, NOS (50) (50) (49) (50) (20)
Hyperplasia 1 (2%) 3 (6%)
Hypertrophy 1 (2%)
Inflammation 2 (10%)
Inflammation, Suppurative 18 (36%) 21 (42%) 14 (29%) 24 (48%) 9 (45%)
Epithelium, Dorsal, Hyperplasia 1 (5%)
Epithelium, Ventral, Hyperplasia 1 (2%) 1 (2%)
Seminal Vesicle (50) (50) (49) (50) (20)
Dilatation 1 (2%)
Testes (50) (50) (49) (50) (20)
Artery, Inflammation 1 (2%)
Germinal Epithelium, Atrophy 6 (12%) 4 (8%) 8 (16%) 7 (14%) 4 (20%)
Interstitial Cell, Hyperplasia 9 (18%) 17 (34%) 7 (14%) 16 (32%) 1 (5%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (49) (50) (20)
Hyperplasia, Reticulum Cell 1 (2%)
Myelofibrosis 1 (2%) 1 (5%)
Lymph Node (8) (10) (14) (11) (1)
Ectasia 1 (7%)
Deep Cervical, Infiltration Cellular,
Histiocyte 1 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 93026-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DECALIN Date: 09/26/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:32:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 25 PPM 50 PPM 100 PPM 400 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Deep Cervical, Inflammation, Suppurative 1 (9%)
Pancreatic, Ectasia 1 (13%) 1 (9%)
Pancreatic, Pigmentation 1 (7%)
Lymph Node, Bronchial (7) (8) (18) (17) (7)
Ectasia 1 (6%) 1 (14%)
Inflammation, Chronic 1 (14%)
Pigmentation 1 (6%)
Lymph Node, Mesenteric (50) (50) (49) (49) (20)
Ectasia 1 (2%) 1 (2%)
Hyperplasia, Lymphohistiocytic 1 (2%)
Lymph Node, Mediastinal (48) (45) (44) (48) (16)
Angiectasis 3 (7%) 1 (2%) 2 (4%) 1 (6%)
Inflammation 1 (2%)
Inflammation, Chronic 1 (2%)
Pigmentation 1 (2%)
Spleen (50) (50) (49) (50) (20)
Accessory Spleen 1 (2%) 2 (4%) 2 (10%)
Congestion 4 (8%)
Fibrosis 3 (6%) 3 (6%) 4 (8%) 5 (10%) 2 (10%)
Hematopoietic Cell Proliferation 1 (2%) 3 (6%)
Hemorrhage 5 (10%) 2 (4%) 2 (4%) 1 (5%)
Hyperplasia, Lymphoid 1 (5%)
Hyperplasia, Lymphohistiocytic 1 (2%) 1 (5%)
Necrosis 1 (2%) 1 (2%) 2 (4%) 2 (4%) 1 (5%)
Thymus (50) (48) (47) (50) (20)
Cyst 1 (2%) 1 (2%)
Metaplasia, Squamous 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (49) (50) (20)
Galactocele 2 (4%) 1 (5%)
Epithelium, Hyperplasia 1 (2%)
Skin (50) (50) (49) (50) (20)
Cyst 3 (6%) 1 (2%)
Cyst Epithelial Inclusion 2 (4%) 2 (4%) 5 (10%)
Hyperkeratosis 2 (4%) 1 (2%) 1 (2%) 1 (5%)
Hyperplasia 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 1 (5%)
Ulcer 1 (2%) 2 (4%)
Subcutaneous Tissue, Fibrosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 93026-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DECALIN Date: 09/26/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:32:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 25 PPM 50 PPM 100 PPM 400 PPM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Subcutaneous Tissue, Hemorrhage 1 (2%)
Subcutaneous Tissue, Inflammation,
Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (49) (50) (20)
Femur, Degeneration 1 (2%)
Joint, Femur, Tibia, Fracture 1 (2%)
Vertebra, Fracture 1 (2%)
Skeletal Muscle (1) (5)
Inflammation, Chronic 1 (20%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (49) (50) (20)
Compression 2 (4%) 2 (4%) 5 (10%) 5 (10%) 1 (5%)
Hemorrhage 2 (4%) 1 (2%) 2 (4%) 3 (6%)
Inflammation, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (50) (49) (49) (20)
Foreign Body 2 (4%) 1 (2%) 3 (6%) 2 (4%)
Inflammation, Chronic 2 (4%) 3 (6%) 2 (4%) 1 (5%)
Inflammation, Suppurative 1 (2%) 1 (2%) 1 (2%) 1 (2%) 1 (5%)
Metaplasia, Squamous 1 (2%)
Epiglottis, Hyperplasia 1 (2%) 1 (5%)
Epiglottis, Metaplasia, Squamous 1 (5%)
Glands, Degeneration 1 (2%)
Squamous Epithelium, Hyperplasia 1 (2%)
Lung (50) (50) (49) (50) (20)
Hemorrhage 1 (2%) 4 (8%) 3 (6%)
Inflammation, Suppurative 1 (2%) 1 (2%) 2 (4%)
Mineralization 1 (2%)
Alveolar Epithelium, Hyperplasia 10 (20%) 8 (16%) 6 (12%) 9 (18%) 4 (20%)
Alveolar Epithelium, Metaplasia, Squamous 1 (2%) 1 (2%) 1 (2%) 1 (5%)
Alveolus, Infiltration Cellular, Histiocyte 14 (28%) 15 (30%) 6 (12%) 11 (22%) 10 (50%)
Alveolus, Pigmentation 1 (2%)
Alveolus, Proteinosis 6 (12%) 7 (14%) 2 (4%) 4 (8%) 2 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 93026-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DECALIN Date: 09/26/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:32:26
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 25 PPM 50 PPM 100 PPM 400 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Bronchiole, Hyperplasia 1 (2%)
Bronchiole, Metaplasia, Squamous 1 (2%)
Goblet Cell, Hyperplasia 1 (2%)
Interstitium, Fibrosis 9 (18%) 10 (20%) 7 (14%) 6 (12%) 4 (20%)
Interstitium, Inflammation, Chronic 5 (10%) 2 (4%) 2 (4%) 1 (2%) 1 (5%)
Nose (49) (49) (49) (50) (20)
Foreign Body 1 (2%) 4 (8%) 2 (4%) 1 (5%)
Inflammation, Suppurative 2 (4%) 4 (8%) 8 (16%) 4 (8%)
Goblet Cell, Hyperplasia 1 (2%) 2 (4%) 2 (4%) 1 (5%)
Nasolacrimal Duct, Inflammation, Suppurative 1 (2%)
Respiratory Epithelium, Hyperplasia 1 (2%) 1 (2%)
Respiratory Epithelium, Metaplasia, Squamous 1 (2%)
Respiratory Epithelium, Necrosis 1 (2%)
Pleura (9) (8) (8) (5) (6)
Inflammation, Chronic 9 (100%) 7 (88%) 6 (75%) 4 (80%) 5 (83%)
Mesothelium, Hyperplasia 1 (13%) 3 (38%) 1 (17%)
Trachea (50) (50) (49) (49) (20)
Inflammation, Suppurative 1 (2%)
Metaplasia, Squamous 1 (2%)
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SPECIAL SENSES SYSTEM
Eye (2) (2) (2) (1)
Atrophy 1 (50%)
Inflammation, Suppurative 1 (50%)
Anterior Chamber, Hemorrhage 1 (50%)
Lens, Cataract 1 (50%) 1 (50%) 2 (100%) 1 (100%)
Harderian Gland (1) (2)
Inflammation, Chronic 1 (100%)
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URINARY SYSTEM
Kidney (50) (50) (49) (50) (20)
Cyst 2 (4%) 1 (2%)
Glomerulosclerosis 1 (2%)
Hydronephrosis 1 (2%)
Infarct 1 (2%) 1 (2%) 1 (2%) 1 (5%)
Inflammation, Suppurative 1 (2%)
Nephropathy, Chronic 48 (96%) 48 (96%) 49 (100%) 50 (100%) 20 (100%)
Cortex, Renal Tubule, Accumulation, Hyaline
Droplet 2 (4%) 9 (18%) 7 (14%) 11 (22%) 2 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 93026-07 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DECALIN Date: 09/26/01
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 14:32:26
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FISCHER 344 RATS MALE CONTROL 25 PPM 50 PPM 100 PPM 400 PPM
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URINARY SYSTEM - CONT
Cortex, Renal Tubule, Atypia Cellular 1 (2%)
Cortex, Renal Tubule, Hyperplasia 11 (22%) 11 (22%) 15 (30%) 5 (25%)
Cortex, Renal Tubule, Mineralization 1 (2%)
Medulla, Casts Granular 1 (5%)
Papilla, Mineralization 1 (2%) 34 (68%) 41 (84%) 43 (86%) 17 (85%)
Pelvis, Inflammation, Suppurative 1 (2%)
Pelvis, Transitional Epithelium, Hyperplasia 1 (2%) 8 (16%) 8 (16%) 10 (20%) 5 (25%)
Urinary Bladder (50) (49) (49) (49) (20)
Calculus Micro Observation Only 1 (2%)
Inflammation, Suppurative 1 (2%)
Muscularis, Hyperplasia 1 (5%)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
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