TDMS Study 93026-07 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest DECALIN DATE: 08/24/01
EXPERIMENT: 93026 TEST: 07 TIME: 11:38:52
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-55392 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: C93026
PATHOLOGIST: RENNE, ROGER CAS: 91-17-8
------------------------------------------------------------------------------------------------------------------------------------
FINAL#1
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Northwest DECALIN DATE: 08/24/01
EXPERIMENT: 93026 TEST: 07 TIME: 11:38:52
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-55392 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: C93026
PATHOLOGIST: RENNE, ROGER CAS: 91-17-8
DECALIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 22 CENSORED DEATHS 0 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 387 421 561 561 572 577 581 589 614 628 |
| 638 638 658 666 680 680 688 694 694 700 |
| 706 728 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 25 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 27 CENSORED DEATHS 0 TERMINAL 23 |
| |
| UNCENSORED DEATHS |
| 315 509 525 532 538 561 567 581 581 589 |
| 592 638 638 644 652 670 673 681 688 694 |
| 701 708 708 721 722 722 725 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 50 PPM |
| --------------------- |
| |
| TOTAL 49 UNCENSORED DEATHS 26 CENSORED DEATHS 0 TERMINAL 23 |
| |
| UNCENSORED DEATHS |
| 574 596 602 605 610 617 617 638 652 658 |
| 665 666 671 680 680 680 688 694 694 699 |
| 708 715 715 716 718 722 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
DECALIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 100 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 30 CENSORED DEATHS 0 TERMINAL 20 |
| |
| UNCENSORED DEATHS |
| 379 419 506 529 561 567 600 613 615 617 |
| 617 634 634 638 649 652 669 673 679 687 |
| 687 687 688 688 705 708 715 716 722 722 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 400 PPM |
| --------------------- |
| |
| TOTAL 20 UNCENSORED DEATHS 6 CENSORED DEATHS 0 TERMINAL 14 |
| |
| UNCENSORED DEATHS |
| 433 694 706 708 708 716 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
DECALIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 733 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 100.0 96.0 96.0 96.0 84.0 74.0 56.0 |
| | |
| | |
|25 PPM | 100.0 100.0 100.0 98.0 98.0 98.0 90.0 78.0 70.0 46.0 |
| | |
| | |
|50 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 91.8 77.6 46.9 |
| | |
| | |
|100 PPM | 100.0 100.0 100.0 100.0 96.0 96.0 92.0 86.0 68.0 40.0 |
| | |
| | |
|400 PPM | 100.0 100.0 100.0 100.0 100.0 95.0 95.0 95.0 95.0 70.0 |
| | |
| | |
==================================================================================
DECALIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 733 DAYS
===============================================================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 25 PPM 50 PPM 100 PPM 400 PPM |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 56.0% 46.0% 46.9% 40.0% 70.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.169N P=0.453 P=0.686 P=0.192 P=0.266N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 621.0 625.0 664.6 632.5 660.8 |
|NATURAL DEATHS (C) | (18.6) (17.9) ( 8.7) (15.5) (45.7) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 683.7 674.7 696.7 672.7 711.4 |
|(STANDARD ERROR) | (11.3) (12.3) ( 6.7) (11.6) (14.9) |
| | |
===============================================================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
DECALIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 734 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = CONTROL |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 18 CENSORED DEATHS 0 TERMINAL 32 |
| |
| UNCENSORED DEATHS |
| 359 525 561 573 609 639 652 652 666 666 |
| 666 680 688 705 716 716 717 722 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 25 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 15 CENSORED DEATHS 0 TERMINAL 35 |
| |
| UNCENSORED DEATHS |
| 499 533 613 635 638 656 663 706 708 708 |
| 722 722 722 728 728 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 100 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 10 CENSORED DEATHS 1 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 349 617 665 665 666 679 680 688 694 722 |
| CENSORED DEATHS |
| 113 |
| |
==================================================================================
DECALIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 734 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 400 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 22 CENSORED DEATHS 0 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 478 492 538 538 561 566 580 589 590 590 |
| 602 618 634 644 644 694 699 700 702 706 |
| 708 708 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
DECALIN
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 734 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 734 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|CONTROL | 100.0 100.0 100.0 98.0 98.0 98.0 96.0 92.0 84.0 64.0 |
| | |
| | |
|25 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 96.0 96.0 86.0 70.0 |
| | |
| | |
|100 PPM | 100.0 100.0 100.0 98.0 98.0 98.0 98.0 98.0 91.8 79.6 |
| | |
| | |
|400 PPM | 100.0 100.0 100.0 100.0 100.0 98.0 92.0 78.0 70.0 56.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| CONTROL 25 PPM 100 PPM 400 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 64.0% 70.0% 79.6% 56.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.076 P=0.554N P=0.124N P=0.391 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 639.6 665.4 642.5 617.3 |
|NATURAL DEATHS (C) | (21.3) (18.6) (33.7) (15.4) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 700.0 713.4 703.3 682.7 |
|(STANDARD ERROR) | ( 9.9) ( 7.1) (14.6) (10.6) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
DECALIN
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
25 PPM = 2
50 PPM = 3
100 PPM = 4
400 PPM = 5
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 41 5 3
| 2 41 41 2 3 3
| 415 2 22 1 33 5
| 22 11 33
P 90 + 2 211 33 55
E | 4 4
R | 2 1 14 13 3 55
C | 2 2 141 3 3
E 80 + 1 1 3 3
N | 2 4 42 33
T | 41 1 1 55
| 242 1 1
S 70 + 42 2 5 5
U | 4 2211
R | 42211
V | 4 22
I 60 + 113
V | 1231
A | 221 1
L | 4 4 22
50 + 4433
| 443 3
| 42 2
|
40 + 4 4
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 35 obs hidden.
DECALIN
KAPLAN-MEIER SURVIVAL CURVES
CONTROL = 1
25 PPM = 2
100 PPM = 3
400 PPM = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 1 4 2
|
| 3 1 4 42 1 2 3
| 4 1 2 1 23 3
95 +
| 11 2 2
| 4 41 1 22
| 33
90 + 1 1 2 33
|
P | 4 4 1 1 2 33
E | 4 4 2 33 2
R 85 +
C | 1 1 3322
E |
N | 3 3
T 80 + 44 2 2 3
|
S | 4 4 1 1
U | 4 4 11
R 75 +
V | 44 1 1
I | 1 1
V |
A 70 + 4 4 2 2
L |
|
| 11
65 +
| 44 1 1
|
|
60 + 44
|
|
| 4 4
55 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 7 obs hidden.