TDMS Study 96001-05 Pathology Tables
NTP Experiment-Test: 96001-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:10:32
FINAL/RATS
Facility: Battelle Northwest
Chemical CAS #: 64742-88-7
Lock Date: 09/24/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 96001-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:10:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 550 1100 2200
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund Sacrifice 12 19 15 23
Natural Death 2 1 3 2
Survivors
Terminal Sacrifice 36 30 32 25
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Jejunum (49) (49) (47) (48)
Leiomyoma 1 (2%)
Liver (49) (50) (50) (50)
Salivary Glands (49) (50) (50) (50)
Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (49) (50) (50) (50)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Adenoma 1 (2%)
Carcinoma 1 (2%)
Adrenal Medulla (50) (50) (50) (50)
Pheochromocytoma Malignant 1 (2%)
Pheochromocytoma Complex 1 (2%)
Pheochromocytoma Benign 2 (4%) 4 (8%) 2 (4%) 2 (4%)
Islets, Pancreatic (49) (50) (50) (50)
Adenoma 1 (2%) 1 (2%)
Carcinoma 1 (2%)
Pituitary Gland (49) (50) (50) (50)
Pars Distalis, Adenoma 27 (55%) 34 (68%) 33 (66%) 28 (56%)
Pars Distalis, Carcinoma 1 (2%) 1 (2%)
Thyroid Gland (49) (50) (50) (50)
C-Cell, Adenoma 3 (6%) 5 (10%) 2 (4%) 4 (8%)
Page 2
NTP Experiment-Test: 96001-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:10:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 550 1100 2200
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
C-Cell, Carcinoma 1 (2%) 2 (4%) 1 (2%)
Follicular Cell, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (49) (50) (50) (50)
Adenoma 3 (6%) 5 (10%) 6 (12%)
Carcinoma 1 (2%) 2 (4%) 1 (2%) 1 (2%)
Ovary (50) (50) (50) (50)
Granulosa Cell Tumor Malignant 1 (2%)
Uterus (49) (50) (50) (50)
Leiomyosarcoma 1 (2%)
Polyp Stromal 10 (20%) 9 (18%) 10 (20%) 9 (18%)
Sarcoma Stromal 1 (2%) 1 (2%)
Cervix, Sarcoma Stromal 1 (2%)
Vagina (1)
Sarcoma 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Histiocytic Sarcoma 1 (2%)
Lymph Node (5) (5) (5) (4)
Lymph Node, Bronchial (12) (7) (8) (11)
Lymph Node, Mandibular (3) (2)
Lymph Node, Mesenteric (50) (50) (50) (49)
Lymph Node, Mediastinal (45) (39) (42) (45)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Spleen (49) (50) (50) (50)
Sarcoma, Metastatic, Skin 1 (2%)
Thymus (47) (47) (46) (48)
Thymoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 96001-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:10:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 550 1100 2200
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Carcinoma 3 (6%) 2 (4%) 9 (18%) 7 (14%)
Carcinoma, Multiple 1 (2%) 1 (2%) 1 (2%)
Fibroadenoma 14 (28%) 13 (26%) 10 (20%) 16 (32%)
Fibroadenoma, Multiple 5 (10%) 13 (26%) 12 (24%) 8 (16%)
Fibroma 1 (2%)
Skin (50) (50) (50) (50)
Basal Cell Adenoma 1 (2%)
Basal Cell Carcinoma 1 (2%)
Keratoacanthoma 1 (2%)
Sarcoma 1 (2%)
Subcutaneous Tissue, Fibroma 2 (4%)
Subcutaneous Tissue, Fibrosarcoma 2 (4%)
Subcutaneous Tissue, Sarcoma 1 (2%)
Subcutaneous Tissue, Schwannoma Benign 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (50) (50) (50)
Carcinoma, Metastatic, Pituitary Gland 1 (2%)
Glioma Malignant 1 (2%)
Cerebellum, Glioma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (49) (50) (50) (50)
Alveolar/Bronchiolar Adenoma 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Carcinoma, Metastatic, Mammary Gland 1 (2%) 2 (4%) 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Medulla 1 (2%)
Pleura (48) (50) (50) (50)
Mesothelium, Carcinoma, Metastatic, Lung 1 (2%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 96001-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:10:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 550 1100 2200
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (50) (50) (50)
Urinary Bladder (49) (50) (50) (50)
Leiomyosarcoma 1 (2%)
Transitional Epithelium, Papilloma 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Histiocytic Sarcoma 1 (2%)
Leukemia Mononuclear 26 (52%) 28 (56%) 26 (52%) 29 (58%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 96001-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:10:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 550 1100 2200
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 44 50 50 48
Total Primary Neoplasms 102 118 127 123
Total Animals with Benign Neoplasms 37 47 42 43
Total Benign Neoplasms 65 81 79 78
Total Animals with Malignant Neoplasms 30 30 36 37
Total Malignant Neoplasms 37 37 48 45
Total Animals with Metastatic Neoplasms 2 1 4 2
Total Metastatic Neoplasm 2 1 4 2
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 96001-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:10:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 138 550 1100
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 50 50 50 50
Early Deaths
Moribund Sacrifice 18 27 21 27
Natural Death 3 4 8 7
Survivors
Terminal Sacrifice 29 19 21 16
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (49) (49) (48) (48)
Intestine Small, Ileum (49) (48) (46) (46)
Liver (50) (50) (50) (50)
Cholangiocarcinoma 1 (2%)
Hepatocellular Adenoma 1 (2%) 1 (2%)
Mesentery (7) (11) (11) (13)
Oral Mucosa (1)
Squamous Cell Carcinoma 1 (100%)
Stomach, Glandular (50) (50) (49) (50)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Atrium, Carcinoma, Metastatic, Kidney 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Medulla (50) (50) (50) (50)
Pheochromocytoma Malignant 1 (2%) 2 (4%)
Pheochromocytoma Benign 5 (10%) 8 (16%) 12 (24%) 13 (26%)
Bilateral, Pheochromocytoma Benign 1 (2%) 1 (2%) 4 (8%)
Islets, Pancreatic (50) (50) (50) (50)
Adenoma 3 (6%) 2 (4%) 1 (2%) 3 (6%)
Carcinoma 1 (2%) 3 (6%)
Pituitary Gland (50) (50) (50) (50)
Pars Distalis, Adenoma 38 (76%) 36 (72%) 35 (70%) 31 (62%)
Pars Distalis, Carcinoma 1 (2%)
Page 7
NTP Experiment-Test: 96001-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:10:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 138 550 1100
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Thyroid Gland (50) (50) (50) (50)
Bilateral, C-Cell, Adenoma 1 (2%) 1 (2%)
C-Cell, Adenoma 7 (14%) 5 (10%) 5 (10%) 4 (8%)
C-Cell, Carcinoma 2 (4%) 3 (6%) 2 (4%)
Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Carcinoma 1 (2%) 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (14) (41) (41) (32)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Preputial Gland (50) (50) (50) (50)
Adenoma 1 (2%) 2 (4%) 1 (2%)
Carcinoma 1 (2%) 3 (6%)
Prostate (50) (50) (50) (50)
Carcinoma 1 (2%)
Testes (50) (50) (50) (50)
Bilateral, Interstitial Cell, Adenoma 26 (52%) 22 (44%) 28 (56%) 30 (60%)
Interstitial Cell, Adenoma 15 (30%) 17 (34%) 10 (20%) 12 (24%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Lymph Node (7) (16) (11) (17)
Lymph Node, Bronchial (15) (12) (16) (13)
Carcinoma, Metastatic, Kidney 1 (6%)
Lymph Node, Mesenteric (50) (50) (50) (50)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Lymph Node, Mediastinal (42) (44) (43) (40)
Carcinoma, Metastatic, Thyroid Gland 1 (3%)
Spleen (50) (50) (50) (50)
Thymus (49) (49) (47) (50)
Thymoma Malignant 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
Page 8
NTP Experiment-Test: 96001-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:10:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 138 550 1100
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Carcinoma 1 (2%) 2 (4%)
Fibroadenoma 3 (6%) 1 (2%) 2 (4%) 4 (8%)
Skin (50) (50) (50) (50)
Basal Cell Carcinoma 1 (2%) 1 (2%) 3 (6%)
Squamous Cell Papilloma 1 (2%) 2 (4%) 2 (4%)
Sebaceous Gland, Adenoma 3 (6%) 1 (2%) 1 (2%)
Subcutaneous Tissue, Fibroma 2 (4%) 4 (8%) 2 (4%) 2 (4%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%) 1 (2%)
Subcutaneous Tissue, Hemangioma 1 (2%)
Subcutaneous Tissue, Lipoma 2 (4%) 1 (2%)
Subcutaneous Tissue, Schwannoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Cranium, Osteosarcoma 1 (2%)
Femur, Osteosarcoma 1 (2%)
Skeletal Muscle (1) (1) (1) (1)
Carcinoma, Metastatic, Thyroid Gland 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Astrocytoma Malignant 1 (2%)
Carcinoma, Metastatic, Pituitary Gland 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (49)
Alveolar/Bronchiolar Adenoma 1 (2%) 2 (4%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (2%)
Carcinoma, Metastatic, Kidney 1 (2%)
Osteosarcoma, Metastatic, Bone 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Medulla 1 (2%)
Thymoma Malignant, Metastatic, Thymus 1 (2%)
Nose (50) (50) (50) (50)
Carcinoma, Metastatic, Oral Mucosa 1 (2%)
Page 9
NTP Experiment-Test: 96001-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:10:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 138 550 1100
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont
Respiratory Epithelium, Adenoma 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Lipoma 1 (2%)
Liposarcoma 1 (2%)
Cortex, Renal Tubule, Adenoma 1 (2%)
Pelvis, Transitional Epithelium, Carcinoma 1 (2%)
Renal Tubule, Carcinoma 1 (2%) 1 (2%)
Urinary Bladder (50) (50) (50) (50)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(50) *(50) *(50) *(50)
Leukemia Mononuclear 25 (50%) 29 (58%) 30 (60%) 30 (60%)
Lymphoma Malignant 1 (2%)
Mesothelioma Malignant 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 96001-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:10:32
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 138 550 1100
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 50 50 50 50
Total Primary Neoplasms 145 143 149 153
Total Animals with Benign Neoplasms 50 50 49 48
Total Benign Neoplasms 107 104 104 109
Total Animals with Malignant Neoplasms 33 33 35 35
Total Malignant Neoplasms 38 39 45 44
Total Animals with Metastatic Neoplasms 2 2 4
Total Metastatic Neoplasm 2 4 5
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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