TDMS Study 96001-05 Pathology Tables
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
FINAL/RATS
Facility: Battelle Northwest
Chemical CAS #: 64742-88-7
Lock Date: 09/24/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5|
DAY ON TEST | 2| 3| 5| 3| 3| 3| 3| 1| 3| 3| 3| 8| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 0| 3|
| 2| 2| 6| 4| 2| 1| 2| 2| 1| 1| 0| 2| 2| 2| 0| 1| 2| 2| 2| 2| 0| 1| 1| 6| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Periesophageal Tissue, Necrosis, | |
Fatty | 4 |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | 2 X |
Clear Cell Focus | 3 1 |
Clear Cell Focus, Multiple | |
Hemorrhage | |
Hepatodiaphragmatic Nodule | 4 4|
Thrombosis | |
Vacuolization Cytoplasmic | 4 3 |
Bile Duct, Cyst | |
Serosa, Fibrosis | |
|__________________________________________________________________________|
Mesentery | + + + + + + |
Necrosis | 3 3 2 3 3 2 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 2
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5|
DAY ON TEST | 2| 3| 5| 3| 3| 3| 3| 1| 3| 3| 3| 8| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 0| 3|
| 2| 2| 6| 4| 2| 1| 2| 2| 1| 1| 0| 2| 2| 2| 0| 1| 2| 2| 2| 2| 0| 1| 1| 6| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Hyperplasia, Squamous | 3 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 1 |
|__________________________________________________________________________|
Tongue | + |
Epithelium, Hyperkeratosis | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Necrosis | |
Vacuolization Cytoplasmic | 1 2 3 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Hyperplasia | 3 4 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3|
Pars Distalis, Cyst | X X X |
Pars Distalis, Hyperplasia | 4 3 3 2 3|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 3 1 1 1 |
__________________________________________|__________________________________________________________________________|
Page 3
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5|
DAY ON TEST | 2| 3| 5| 3| 3| 3| 3| 1| 3| 3| 3| 8| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 0| 3|
| 2| 2| 6| 4| 2| 1| 2| 2| 1| 1| 0| 2| 2| 2| 0| 1| 2| 2| 2| 2| 0| 1| 1| 6| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Peritoneum | + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Cyst | X |
Hyperplasia | 1 3 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Endometrium, Hyperplasia, Cystic | |
Endometrium, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + +|
|__________________________________________________________________________|
Lymph Node, Bronchial | M M M M M M M M M + M + M + M M M M M M + M M M +|
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M M M M M + M M M M M + M M M M M M +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + + + M + + + M|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | X|
Hematopoietic Cell Proliferation | 4 |
Hemorrhage | |
Necrosis | |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________|__________________________________________________________________________|
Page 4
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5|
DAY ON TEST | 2| 3| 5| 3| 3| 3| 3| 1| 3| 3| 3| 8| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 0| 3|
| 2| 2| 6| 4| 2| 1| 2| 2| 1| 1| 0| 2| 2| 2| 0| 1| 2| 2| 2| 2| 0| 1| 1| 6| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | |
Inflammation, Chronic | 3 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperkeratosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 2 3 3 3 |
Hemorrhage | 3 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 4 |
Inflammation, Chronic | 2 |
Epiglottis, Metaplasia, Squamous | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Alveolar Epithelium, Hyperplasia | 1 1|
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 2 1 1 1 1 2 1 1 1 1 |
Interstitium, Fibrosis | 3|
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X 1 |
Inflammation, Suppurative | 3 |
Goblet Cell, Hyperplasia | 2 |
__________________________________________|__________________________________________________________________________|
Page 5
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5|
DAY ON TEST | 2| 3| 5| 3| 3| 3| 3| 1| 3| 3| 3| 8| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 0| 3|
| 2| 2| 6| 4| 2| 1| 2| 2| 1| 1| 0| 2| 2| 2| 0| 1| 2| 2| 2| 2| 0| 1| 1| 6| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 2 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 2 1 2 1|
|__________________________________________________________________________|
Pleura | + + + + + + + + + + + + + + + + + + + + + + + + |
Fibrosis | 1 2 1 1 1 2 |
Inflammation, Chronic | 1 1 2 2 1 1 2 2 1 1 1 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cornea, Hyperplasia | |
Lens, Cataract | 4 2 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 1 2 1 1 2 3 2 1 1 3 2 2 1 1 2 3 1 1 3 1 1 1 3 |
Cortex, Infarct | 3 |
Cortex, Renal Tubule, Inflammation | 2 |
Papilla, Mineralization | 1 |
Pelvis, Transitional Epithelium, | |
Hyperplasia | 2 |
Pelvis, Transitional Epithelium, | |
Mineralization | 1 1 2 1 1 1 2 1 1 1 1 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | 3 |
Transitional Epithelium, Ulcer | 4 |
__________________________________________|__________________________________________________________________________
Page 6
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| |
DAY ON TEST | 3| 5| 3| 3| 3| 9| 9| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 4| 8| 3| 3| 3| |
| 0| 6| 1| 1| 0| 8| 5| 1| 0| 2| 2| 0| 1| 2| 9| 2| 1| 1| 1| 2| 0| 1| 1| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Periesophageal Tissue, Necrosis, | | |
Fatty | | 1 4.0|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + A + + + + + + + + + + + + + A + + + +| 48 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Angiectasis | 2 | 1 2.0|
Basophilic Focus | | 2 2.0|
Clear Cell Focus | 3 1 2 X X| 7 2.0|
Clear Cell Focus, Multiple | 3 2 | 2 2.5|
Hemorrhage | 4 | 1 4.0|
Hepatodiaphragmatic Nodule | 4 4 4 | 5 4.0|
Thrombosis | 4 | 1 4.0|
Vacuolization Cytoplasmic | | 2 3.5|
Bile Duct, Cyst | X | 1 |
Serosa, Fibrosis | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + +| 11 |
Necrosis | 3 3 4 3 3| 11 2.9|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Acinus, Atrophy | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| |
DAY ON TEST | 3| 5| 3| 3| 3| 9| 9| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 4| 8| 3| 3| 3| |
| 0| 6| 1| 1| 0| 8| 5| 1| 0| 2| 2| 0| 1| 2| 9| 2| 1| 1| 1| 2| 0| 1| 1| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Hyperplasia, Squamous | | 1 3.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Necrosis | | 1 1.0|
|__________________________________________________________________________|____________|
Tongue | | 1 |
Epithelium, Hyperkeratosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Cardiomyopathy | | 1 2.0|
Atrium, Thrombosis | 4 3 | 2 3.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 | 1 4.0|
Necrosis | 4 | 1 4.0|
Vacuolization Cytoplasmic | 2 1 3 3 3 | 9 2.1|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 3.0|
Hyperplasia | 4 3 | 4 3.5|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| |
DAY ON TEST | 3| 5| 3| 3| 3| 9| 9| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 4| 8| 3| 3| 3| |
| 0| 6| 1| 1| 0| 8| 5| 1| 0| 2| 2| 0| 1| 2| 9| 2| 1| 1| 1| 2| 0| 1| 1| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Pars Distalis, Angiectasis | 4 | 2 3.5|
Pars Distalis, Cyst | X X | 5 |
Pars Distalis, Hyperplasia | 3 4 2 2 | 9 2.9|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
C-Cell, Hyperplasia | 2 1 4 2 1 1| 11 1.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | + + + + + + + + + + + + + + + + + + + + +| 43 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | | 1 |
Hyperplasia | | 2 2.0|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X X X | 8 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Hemorrhage | | 1 4.0|
Endometrium, Hyperplasia, Cystic | 1 | 1 1.0|
Endometrium, Hyperplasia | | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node | + | 5 |
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M M M + + + M M M M M M + + M M M M + M M M M M| 12 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| |
DAY ON TEST | 3| 5| 3| 3| 3| 9| 9| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 4| 8| 3| 3| 3| |
| 0| 6| 1| 1| 0| 8| 5| 1| 0| 2| 2| 0| 1| 2| 9| 2| 1| 1| 1| 2| 0| 1| 1| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M| 3 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + M + + + + + + + + + + + + + + + M + + M + +| 45 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Accessory Spleen | | 1 |
Hematopoietic Cell Proliferation | 4 | 2 4.0|
Hemorrhage | 4 | 1 4.0|
Necrosis | 4 4 | 2 4.0|
|__________________________________________________________________________|____________|
Thymus | + + + M + + + + + + + + + + + + + + + + A + + + +| 47 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 1 | 1 1.0|
Inflammation, Chronic | | 1 3.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperkeratosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Compression | 4 3 1 3 3 | 9 2.8|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| |
DAY ON TEST | 3| 5| 3| 3| 3| 9| 9| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 4| 8| 3| 3| 3| |
| 0| 6| 1| 1| 0| 8| 5| 1| 0| 2| 2| 0| 1| 2| 9| 2| 1| 1| 1| 2| 0| 1| 1| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
Hemorrhage | 2 4 | 4 2.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Foreign Body | 4 | 2 4.0|
Inflammation, Chronic | 2 2 | 3 2.0|
Epiglottis, Metaplasia, Squamous | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Hemorrhage | | 1 1.0|
Alveolar Epithelium, Hyperplasia | 1 | 3 1.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 2 1 1 1 1 1 1 2 2 | 22 1.3|
Interstitium, Fibrosis | 1 | 2 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Foreign Body | | 2 1.0|
Inflammation, Suppurative | | 1 3.0|
Goblet Cell, Hyperplasia | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 3 | 2 2.5|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 2 2 2 1 1 1 2 1 | 12 1.5|
|__________________________________________________________________________|____________|
Pleura | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
Fibrosis | 2 2 1 2 1 1 2 2 1 2 1 2 | 18 1.5|
Inflammation, Chronic | 2 2 1 1 2 2 1 2 1 2 | 21 1.5|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
__________________________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| |
DAY ON TEST | 3| 5| 3| 3| 3| 9| 9| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 4| 8| 3| 3| 3| |
| 0| 6| 1| 1| 0| 8| 5| 1| 0| 2| 2| 0| 1| 2| 9| 2| 1| 1| 1| 2| 0| 1| 1| 1| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
Cornea, Hyperplasia | 2 | 1 2.0|
Lens, Cataract | 4 | 3 3.3|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
|__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Nephropathy, Chronic | 1 1 2 2 1 2 1 1 3 1 1 2 1 1 2 3 3 2 2| 42 1.7|
Cortex, Infarct | | 1 3.0|
Cortex, Renal Tubule, Inflammation | | 1 2.0|
Papilla, Mineralization | 2 1 | 3 1.3|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | 1 1 1| 4 1.3|
Pelvis, Transitional Epithelium, | | |
Mineralization | 2 1 2 1 1 1 1 2 1 1 1 1 1 1 | 25 1.2|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Transitional Epithelium, Hyperplasia | | 1 3.0|
Transitional Epithelium, Ulcer | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 7| 5| 7| 6| 7| 5| 7| 7| 7| 6| 5| 4| 7| 7| 7| 7| 7| 6| 7| 4| 7|
DAY ON TEST | 7| 3| 1| 9| 3| 7| 3| 5| 3| 0| 3| 3| 3| 9| 3| 8| 3| 3| 3| 3| 3| 5| 3| 8| 3|
| 5| 1| 9| 3| 0| 5| 0| 6| 1| 6| 2| 1| 1| 1| 7| 1| 1| 0| 1| 1| 0| 2| 1| 1| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
550 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Basophilic Focus | 2 X |
Clear Cell Focus | 4 3 X X 2 |
Hepatodiaphragmatic Nodule | 4 4 4|
Vacuolization Cytoplasmic | 4 3 |
|__________________________________________________________________________|
Mesentery | + + + + + + |
Necrosis | 2 3 3 3 3 3 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 4 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tongue | + + |
Epithelium, Hyperplasia | 3 4 |
__________________________________________|__________________________________________________________________________|
Page 13
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 7| 5| 7| 6| 7| 5| 7| 7| 7| 6| 5| 4| 7| 7| 7| 7| 7| 6| 7| 4| 7|
DAY ON TEST | 7| 3| 1| 9| 3| 7| 3| 5| 3| 0| 3| 3| 3| 9| 3| 8| 3| 3| 3| 3| 3| 5| 3| 8| 3|
| 5| 1| 9| 3| 0| 5| 0| 6| 1| 6| 2| 1| 1| 1| 7| 1| 1| 0| 1| 1| 0| 2| 1| 1| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
550 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrium, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 1 |
Vacuolization Cytoplasmic | 3 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 3 4 4 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Peritoneum | + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 4 |
Inflammation, Chronic | |
Metaplasia, Squamous | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 14
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 7| 5| 7| 6| 7| 5| 7| 7| 7| 6| 5| 4| 7| 7| 7| 7| 7| 6| 7| 4| 7|
DAY ON TEST | 7| 3| 1| 9| 3| 7| 3| 5| 3| 0| 3| 3| 3| 9| 3| 8| 3| 3| 3| 3| 3| 5| 3| 8| 3|
| 5| 1| 9| 3| 0| 5| 0| 6| 1| 6| 2| 1| 1| 1| 7| 1| 1| 0| 1| 1| 0| 2| 1| 1| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
550 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X|
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hemorrhage | |
Endometrium, Hyperplasia, Cystic | 2 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Reticulum Cell | 4 |
|__________________________________________________________________________|
Lymph Node | + + |
Pancreatic, Infiltration Cellular, | |
Histiocyte | |
|__________________________________________________________________________|
Lymph Node, Bronchial | M M M M M M M M M + M M M + M M M M M M M M M + M|
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + + + + + + M M + + M + M|
Angiectasis | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | |
Hemorrhage | |
Necrosis | |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + M + + + + +|
Cyst | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 15
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 7| 5| 7| 6| 7| 5| 7| 7| 7| 6| 5| 4| 7| 7| 7| 7| 7| 6| 7| 4| 7|
DAY ON TEST | 7| 3| 1| 9| 3| 7| 3| 5| 3| 0| 3| 3| 3| 9| 3| 8| 3| 3| 3| 3| 3| 5| 3| 8| 3|
| 5| 1| 9| 3| 0| 5| 0| 6| 1| 6| 2| 1| 1| 1| 7| 1| 1| 0| 1| 1| 0| 2| 1| 1| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
550 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 2 2 3 3 |
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Chronic | 2 |
Respiratory Epithelium, Hyperplasia | 1 |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Alveolar Epithelium, Hyperplasia | 1 |
Alveolar Epithelium, Metaplasia, | |
Squamous | 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 2 1 2 1 2 |
Interstitium, Fibrosis | 1 2 |
Vein, Fibrosis | 4 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Suppurative | 3 2 |
Goblet Cell, Hyperplasia | 3 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 2 1 1 1 1 2 1 1 1 |
Olfactory Epithelium, Hyperplasia | |
__________________________________________|__________________________________________________________________________|
Page 16
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
_____________________________________________________________________________________________________________________
| 6| 7| 7| 5| 7| 5| 7| 6| 7| 5| 7| 7| 7| 6| 5| 4| 7| 7| 7| 7| 7| 6| 7| 4| 7|
DAY ON TEST | 7| 3| 1| 9| 3| 7| 3| 5| 3| 0| 3| 3| 3| 9| 3| 8| 3| 3| 3| 3| 3| 5| 3| 8| 3|
| 5| 1| 9| 3| 0| 5| 0| 6| 1| 6| 2| 1| 1| 1| 7| 1| 1| 0| 1| 1| 0| 2| 1| 1| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
550 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Respiratory Epithelium, Metaplasia, | |
Squamous | 2 |
|__________________________________________________________________________|
Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 1 1 1 |
Inflammation, Chronic | 1 1 1 2 1 1 1 1 1 2 |
Mesothelium, Hyperplasia | 1 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Anterior Chamber, Inflammation, | |
Suppurative | |
Lens, Cataract | 4 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Fibrosis | |
Infarct | 2 |
Nephropathy, Chronic | 3 1 3 4 1 1 1 2 1 1 1 1 2 2 3 2 2 1 2 1|
Papilla, Mineralization | |
Pelvis, Transitional Epithelium, | |
Hyperplasia | 3 1 |
Pelvis, Transitional Epithelium, | |
Mineralization | 1 3 2 1 1 1 1 1 1 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Muscularis, Infiltration Cellular, | |
Histiocyte | |
__________________________________________|__________________________________________________________________________
Page 17
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| |
DAY ON TEST | 2| 3| 4| 3| 3| 3| 3| 3| 2| 3| 2| 3| 0| 3| 5| 0| 3| 3| 3| 0| 3| 3| 3| 7| 3| |
| 6| 2| 6| 1| 2| 1| 2| 2| 9| 2| 6| 0| 3| 1| 6| 3| 1| 2| 2| 6| 1| 1| 1| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
550 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 2 2.5|
Basophilic Focus | 1 | 3 1.5|
Clear Cell Focus | 1 2 | 7 2.4|
Hepatodiaphragmatic Nodule | 4 4 4 4 4 4 | 9 4.0|
Vacuolization Cytoplasmic | 3 3 3 | 5 3.2|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + | 15 |
Necrosis | 3 3 3 3 3 3 3 3 3 | 15 2.9|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | 4 | 2 4.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| |
DAY ON TEST | 2| 3| 4| 3| 3| 3| 3| 3| 2| 3| 2| 3| 0| 3| 5| 0| 3| 3| 3| 0| 3| 3| 3| 7| 3| |
| 6| 2| 6| 1| 2| 1| 2| 2| 9| 2| 6| 0| 3| 1| 6| 3| 1| 2| 2| 6| 1| 1| 1| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
550 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Tongue | + | 3 |
Epithelium, Hyperplasia | 4 | 3 3.7|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrium, Thrombosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | | 1 1.0|
Vacuolization Cytoplasmic | 2 1 | 4 1.8|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 2 3.5|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Cyst | X X X | 3 |
Pars Distalis, Hyperplasia | 2 3 2 3 3 2| 9 2.9|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 4 3 2 1| 6 2.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| |
DAY ON TEST | 2| 3| 4| 3| 3| 3| 3| 3| 2| 3| 2| 3| 0| 3| 5| 0| 3| 3| 3| 0| 3| 3| 3| 7| 3| |
| 6| 2| 6| 1| 2| 1| 2| 2| 9| 2| 6| 0| 3| 1| 6| 3| 1| 2| 2| 6| 1| 1| 1| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
550 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENERAL BODY SYSTEM - cont | | |
Peritoneum | + + + + + + + + + + + + + + + + + + + + + + + +| 43 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 3 3.0|
Inflammation, Chronic | 4 | 1 4.0|
Metaplasia, Squamous | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X X X| 9 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 | 1 4.0|
Hemorrhage | 4 | 1 4.0|
Endometrium, Hyperplasia, Cystic | 3 3 4 | 5 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Reticulum Cell | | 1 4.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + | 5 |
Pancreatic, Infiltration Cellular, | | |
Histiocyte | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M M M + M M M M M M M M M M M + M M M + M M + M| 7 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M| |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M + + + + M M + + M + + + M + + + + + M + + + +| 39 |
Angiectasis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| |
DAY ON TEST | 2| 3| 4| 3| 3| 3| 3| 3| 2| 3| 2| 3| 0| 3| 5| 0| 3| 3| 3| 0| 3| 3| 3| 7| 3| |
| 6| 2| 6| 1| 2| 1| 2| 2| 9| 2| 6| 0| 3| 1| 6| 3| 1| 2| 2| 6| 1| 1| 1| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
550 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | 4 | 1 4.0|
Hemorrhage | 4 | 1 4.0|
Necrosis | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + M + + + + + + + M + + + +| 47 |
Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 4 2 3 | 8 2.8|
Hemorrhage | 2 4 | 3 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 4 | 1 4.0|
Inflammation, Chronic | | 1 2.0|
Respiratory Epithelium, Hyperplasia | | 1 1.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| |
DAY ON TEST | 2| 3| 4| 3| 3| 3| 3| 3| 2| 3| 2| 3| 0| 3| 5| 0| 3| 3| 3| 0| 3| 3| 3| 7| 3| |
| 6| 2| 6| 1| 2| 1| 2| 2| 9| 2| 6| 0| 3| 1| 6| 3| 1| 2| 2| 6| 1| 1| 1| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
550 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 2 | 2 1.5|
Alveolar Epithelium, Hyperplasia | | 1 1.0|
Alveolar Epithelium, Metaplasia, | | |
Squamous | | 1 1.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 2 2 1 1 1 2| 14 1.4|
Interstitium, Fibrosis | | 2 1.5|
Vein, Fibrosis | | 1 4.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 3 3 | 2 3.0|
Inflammation, Suppurative | 1 1 2 | 5 1.8|
Goblet Cell, Hyperplasia | 2 2 | 3 2.3|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 2 1 1 1 1 1 1 1 | 18 1.2|
Olfactory Epithelium, Hyperplasia | 2 | 1 2.0|
Respiratory Epithelium, Metaplasia, | | |
Squamous | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 1 1 | 6 1.3|
Inflammation, Chronic | 2 1 2 2 2 1 1 1 1 2| 20 1.4|
Mesothelium, Hyperplasia | | 1 1.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 | 1 4.0|
Anterior Chamber, Inflammation, | | |
Suppurative | 1 | 1 1.0|
Lens, Cataract | 4 | 2 4.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| |
DAY ON TEST | 2| 3| 4| 3| 3| 3| 3| 3| 2| 3| 2| 3| 0| 3| 5| 0| 3| 3| 3| 0| 3| 3| 3| 7| 3| |
| 6| 2| 6| 1| 2| 1| 2| 2| 9| 2| 6| 0| 3| 1| 6| 3| 1| 2| 2| 6| 1| 1| 1| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| A |
550 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 2 |
Fibrosis | 4 | 1 4.0|
Infarct | | 1 2.0|
Nephropathy, Chronic | 1 2 1 2 2 2 2 3 1 4 1 3 2 2 1 2 1 1 1 2 2 1 3 1| 44 1.8|
Papilla, Mineralization | 2 | 1 2.0|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | 1 | 3 1.7|
Pelvis, Transitional Epithelium, | | |
Mineralization | 1 1 1 1 1 1 1 1 2 2 1 1 1 2| 23 1.3|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 1 3.0|
Muscularis, Infiltration Cellular, | | |
Histiocyte | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
_____________________________________________________________________________________________________________________
| 4| 7| 7| 5| 5| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7|
DAY ON TEST | 0| 0| 3| 8| 6| 3| 3| 3| 8| 3| 3| 8| 9| 1| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3|
| 1| 3| 0| 1| 5| 1| 0| 0| 2| 2| 1| 9| 8| 0| 2| 0| 0| 1| 1| 0| 2| 3| 5| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1100 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + A + + + + + + + + + + + + +|
Ulcer | 4 |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + A + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 |
Basophilic Focus | X |
Clear Cell Focus | 2 1 |
Clear Cell Focus, Multiple | |
Degeneration, Cystic | |
Hematopoietic Cell Proliferation | 4 |
Hepatodiaphragmatic Nodule | 4 4 4 4 |
Necrosis | 3 |
Vacuolization Cytoplasmic | 2 3 |
|__________________________________________________________________________|
Mesentery | + + + + + + + + + + |
Necrosis | 3 3 3 3 3 2 3 3 4 4 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 4 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 24
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
_____________________________________________________________________________________________________________________
| 4| 7| 7| 5| 5| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7|
DAY ON TEST | 0| 0| 3| 8| 6| 3| 3| 3| 8| 3| 3| 8| 9| 1| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3|
| 1| 3| 0| 1| 5| 1| 0| 0| 2| 2| 1| 9| 8| 0| 2| 0| 0| 1| 1| 0| 2| 3| 5| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1100 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Atrium, Thrombosis | 4 |
Ventricle, Hypertrophy | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vacuolization Cytoplasmic | 4 3 3 3 2 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 1 3 1 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | 4 2 3 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Peritoneum | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 1 |
Inflammation, Chronic | 2 |
__________________________________________|__________________________________________________________________________|
Page 25
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
_____________________________________________________________________________________________________________________
| 4| 7| 7| 5| 5| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7|
DAY ON TEST | 0| 0| 3| 8| 6| 3| 3| 3| 8| 3| 3| 8| 9| 1| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3|
| 1| 3| 0| 1| 5| 1| 0| 0| 2| 2| 1| 9| 8| 0| 2| 0| 0| 1| 1| 0| 2| 3| 5| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1100 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Endometrium, Hyperplasia, Cystic | 2 |
Endometrium, Hyperplasia | 3 |
|__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + |
|__________________________________________________________________________|
Lymph Node, Bronchial | M M M M M M M + M M M M M + M + M M M M M M M M M|
Pigmentation | |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M + M M M M M M M + M M M M M M M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + + + M + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | X |
Fibrosis | |
Hematopoietic Cell Proliferation | 4 |
Hemorrhage | 4 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + M + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 26
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
_____________________________________________________________________________________________________________________
| 4| 7| 7| 5| 5| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7|
DAY ON TEST | 0| 0| 3| 8| 6| 3| 3| 3| 8| 3| 3| 8| 9| 1| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3|
| 1| 3| 0| 1| 5| 1| 0| 0| 2| 2| 1| 9| 8| 0| 2| 0| 0| 1| 1| 0| 2| 3| 5| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1100 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
Galactocele | |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Hyperkeratosis | 4|
Inflammation, Granulomatous | |
Ulcer | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 3 |
Gliosis | 4 |
Hemorrhage | 3 4 4 2 |
Necrosis | 4 |
Cerebellum, Developmental | |
Malformation | |
Cerebellum, Gliosis | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1|
Alveolar Epithelium, Hyperplasia | 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 1 2 1 2 1 1 1 2 1 |
Interstitium, Fibrosis | 2 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 |
Goblet Cell, Hyperplasia | 3 |
__________________________________________|__________________________________________________________________________|
Page 27
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
_____________________________________________________________________________________________________________________
| 4| 7| 7| 5| 5| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 4| 6| 7| 7|
DAY ON TEST | 0| 0| 3| 8| 6| 3| 3| 3| 8| 3| 3| 8| 9| 1| 3| 3| 3| 3| 3| 3| 3| 3| 9| 3| 3|
| 1| 3| 0| 1| 5| 1| 0| 0| 2| 2| 1| 9| 8| 0| 2| 0| 0| 1| 1| 0| 2| 3| 5| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1100 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | 3 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 2 1 2 1 2 1 1 2 1 1 |
|__________________________________________________________________________|
Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 2 1 1 2 2 1 2 |
Inflammation, Chronic | 2 2 2 1 2 2 2 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lens, Cataract | 3 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 3 |
Nephropathy, Chronic | 2 3 1 2 3 2 3 2 3 3 1 1 2 1 2 1 1 1 2 1 1 2|
Cortex, Renal Tubule, Hyperplasia | |
Papilla, Mineralization | |
Pelvis, Transitional Epithelium, | |
Hyperplasia | 1 1 1 |
Pelvis, Transitional Epithelium, | |
Mineralization | 2 1 1 1 1 2 1 1 1 1 1 1 1 1|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | |
__________________________________________|__________________________________________________________________________
Page 28
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 1| 0| 3| 3| 2| 3| 8| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 6| 2| 1| 3| |
| 0| 1| 0| 0| 5| 0| 1| 6| 1| 3| 1| 1| 2| 0| 2| 0| 1| 1| 0| 1| 0| 3| 2| 8| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
1100 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + + + +| 47 |
Ulcer | | 1 4.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 2 1.5|
Basophilic Focus | | 1 |
Clear Cell Focus | 3 1 X 3| 6 2.0|
Clear Cell Focus, Multiple | 1 | 1 1.0|
Degeneration, Cystic | 2 | 1 2.0|
Hematopoietic Cell Proliferation | | 1 4.0|
Hepatodiaphragmatic Nodule | 4 | 5 4.0|
Necrosis | 3 | 2 3.0|
Vacuolization Cytoplasmic | 4 2 3 3 | 6 2.8|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + + +| 23 |
Necrosis | 3 4 3 3 3 3 3 3 4 3 3 4 3| 23 3.2|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | | 1 4.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 1| 0| 3| 3| 2| 3| 8| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 6| 2| 1| 3| |
| 0| 1| 0| 0| 5| 0| 1| 6| 1| 3| 1| 1| 2| 0| 2| 0| 1| 1| 0| 1| 0| 3| 2| 8| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
1100 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 | 1 2.0|
Atrium, Thrombosis | 3 | 2 3.5|
Ventricle, Hypertrophy | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Vacuolization Cytoplasmic | 2 1 2 1 2 2 2 4 3| 15 2.3|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 1 4 | 7 2.3|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 4 | 1 4.0|
Pars Distalis, Angiectasis | 2 | 2 2.5|
Pars Distalis, Cyst | X X | 3 |
Pars Distalis, Hyperplasia | 3 3 3 3 3 | 8 3.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 3 3 1 2 | 4 2.3|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 1| 0| 3| 3| 2| 3| 8| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 6| 2| 1| 3| |
| 0| 1| 0| 0| 5| 0| 1| 6| 1| 3| 1| 1| 2| 0| 2| 0| 1| 1| 0| 1| 0| 3| 2| 8| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
1100 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | + + + + + + + + + + + + + + + + + + + + + + + +| 45 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 3 2.0|
Inflammation, Chronic | | 1 2.0|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X X| 8 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 4.0|
Endometrium, Hyperplasia, Cystic | 3| 2 2.5|
Endometrium, Hyperplasia | | 1 3.0|
|__________________________________________________________________________|____________|
Vagina | + | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node | + + + | 5 |
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M + + M M M M M M M M M M M M M M + M M + M M +| 8 |
Pigmentation | 2 3| 2 2.5|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M| 2 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + M M + + M + + + + + M + + + + + + + M M M| 42 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 1| 0| 3| 3| 2| 3| 8| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 6| 2| 1| 3| |
| 0| 1| 0| 0| 5| 0| 1| 6| 1| 3| 1| 1| 2| 0| 2| 0| 1| 1| 0| 1| 0| 3| 2| 8| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
1100 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Spleen | X | 2 |
Fibrosis | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 4 | 2 4.0|
Hemorrhage | 4 | 2 4.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + M + + + + + + + + + M + + + + + + + M +| 46 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 2 2 | 2 2.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | 4 | 1 4.0|
Hyperkeratosis | | 1 4.0|
Inflammation, Granulomatous | 4 | 1 4.0|
Ulcer | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 3| 3 3.0|
Gliosis | | 1 4.0|
Hemorrhage | 1 4 | 6 3.0|
Necrosis | | 1 4.0|
Cerebellum, Developmental | | |
Malformation | 2 | 1 2.0|
Cerebellum, Gliosis | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 1| 0| 3| 3| 2| 3| 8| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 6| 2| 1| 3| |
| 0| 1| 0| 0| 5| 0| 1| 6| 1| 3| 1| 1| 2| 0| 2| 0| 1| 1| 0| 1| 0| 3| 2| 8| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
1100 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 2 4 | 2 3.0|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 1.0|
Alveolar Epithelium, Hyperplasia | | 1 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 | 13 1.3|
Interstitium, Fibrosis | 1 | 2 1.5|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + A + + + + + + + + + + + + + + +| 49 |
Inflammation, Suppurative | 2 2 | 3 2.0|
Goblet Cell, Hyperplasia | 2 2 | 3 2.3|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | | 1 3.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 1 1 1 1 | 15 1.3|
|__________________________________________________________________________|____________|
Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 1 | 9 1.6|
Inflammation, Chronic | 1 1 2 1 1| 13 1.6|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lens, Cataract | | 1 3.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 1| 0| 3| 3| 2| 3| 8| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 6| 2| 1| 3| |
| 0| 1| 0| 0| 5| 0| 1| 6| 1| 3| 1| 1| 2| 0| 2| 0| 1| 1| 0| 1| 0| 3| 2| 8| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| A |
1100 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | | 1 3.0|
Nephropathy, Chronic | 1 2 2 1 2 2 1 1 2 2 2 3 1 2 1 2 4 3 2 4 2 1 4 3| 46 2.0|
Cortex, Renal Tubule, Hyperplasia | 1 | 1 1.0|
Papilla, Mineralization | 1 | 1 1.0|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | 1 1 1 4 | 7 1.4|
Pelvis, Transitional Epithelium, | | |
Mineralization | 2 1 1 1 1 2 1 1 1 1 1 1 1| 27 1.1|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Transitional Epithelium, Hyperplasia | 1 1 | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 3| 8| 3| 1| 3| 3| 0| 4| 9| 3| 1| 0| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3|
| 2| 1| 0| 2| 2| 1| 2| 2| 2| 6| 9| 3| 1| 4| 6| 1| 1| 1| 1| 0| 5| 2| 0| 1| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
2200 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | 1 |
Clear Cell Focus | 1 1 |
Clear Cell Focus, Multiple | 3 |
Hepatodiaphragmatic Nodule | 4 |
Vacuolization Cytoplasmic | |
Hepatocyte, Regeneration | 4 4|
Serosa, Fibrosis | 3 |
|__________________________________________________________________________|
Mesentery | + + + + + +|
Necrosis | 3 4 3 3 3 3|
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Thrombosis | 4 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 35
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 3| 8| 3| 1| 3| 3| 0| 4| 9| 3| 1| 0| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3|
| 2| 1| 0| 2| 2| 1| 2| 2| 2| 6| 9| 3| 1| 4| 6| 1| 1| 1| 1| 0| 5| 2| 0| 1| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
2200 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Tongue | |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Atrium, Thrombosis | |
Myocardium, Degeneration | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 3 |
Vacuolization Cytoplasmic | 1 1 4 3 2 1 4 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 4 |
Hyperplasia | 3 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 3 |
Pars Distalis, Cyst | X |
Pars Distalis, Hemorrhage | 4 |
Pars Distalis, Hyperplasia | 4 4 3 3 3 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 4 3|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Peritoneum | + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 36
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 3| 8| 3| 1| 3| 3| 0| 4| 9| 3| 1| 0| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3|
| 2| 1| 0| 2| 2| 1| 2| 2| 2| 6| 9| 3| 1| 4| 6| 1| 1| 1| 1| 0| 5| 2| 0| 1| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
2200 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Inflammation, Chronic | 4 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Decidual Reaction | |
Degeneration | |
Hemorrhage | 4 |
Necrosis | |
Prolapse | |
Capillary, Myometrium, Hyperplasia | |
Endometrium, Hyperplasia | |
Endometrium, Inflammation, | |
Suppurative | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + |
|__________________________________________________________________________|
Lymph Node, Bronchial | M + + M + + + M M M M M M + M M M M M M + M M M M|
Infiltration Cellular, Histiocyte | 4 |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + M + + + + + + + + + + + + + + + + + +|
Necrosis | 4 |
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + M + + + + M + + + + + + + + + M + + +|
Hemorrhage | 3 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
__________________________________________|__________________________________________________________________________|
Page 37
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 3| 8| 3| 1| 3| 3| 0| 4| 9| 3| 1| 0| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3|
| 2| 1| 0| 2| 2| 1| 2| 2| 2| 6| 9| 3| 1| 4| 6| 1| 1| 1| 1| 0| 5| 2| 0| 1| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
2200 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Hemorrhage | 4 |
Necrosis | 4 |
Thrombosis | 4 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + M + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | |
Epithelium, Hyperplasia | 3 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | 4 |
Inflammation, Chronic | 1 |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 3 2 4 2|
Hemorrhage | |
|__________________________________________________________________________|
Spinal Cord | + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + I + + + + + +|
Foreign Body | |
Epiglottis, Metaplasia, Squamous | 2 |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Necrosis | 4 |
__________________________________________|__________________________________________________________________________|
Page 38
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 3| 8| 3| 1| 3| 3| 0| 4| 9| 3| 1| 0| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3|
| 2| 1| 0| 2| 2| 1| 2| 2| 2| 6| 9| 3| 1| 4| 6| 1| 1| 1| 1| 0| 5| 2| 0| 1| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
2200 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Alveolar Epithelium, Hyperplasia | 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 1 2 2 |
Alveolus, Proteinosis | |
Bronchiole, Hyperplasia, Focal | 2 |
Interstitium, Fibrosis | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Goblet Cell, Hyperplasia | 2 |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
Olfactory Epithelium, Degeneration, | |
Hyaline | 1 1 1 1 1 4 1 1 1 1 2 2 2 1|
|__________________________________________________________________________|
Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 1 2 2 |
Inflammation, Chronic | 1 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | |
|__________________________________________________________________________|
Eye | I + + + + + + + + + + + + + + + + + + + + + + + +|
Lens, Cataract | 3 4 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Nephropathy, Chronic | 1 1 1 1 1 1 1 3 2 1 1 3 1 1 4 2 1 2 1 2 1 3 2 3|
Cortex, Inflammation, Suppurative | 1 |
Cortex, Renal Tubule, Accumulation, | |
Hyaline Droplet | 3 |
Pelvis, Transitional Epithelium, | |
__________________________________________|__________________________________________________________________________|
Page 39
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 6| 7| 7| 5| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7|
DAY ON TEST | 8| 3| 3| 3| 8| 3| 1| 3| 3| 0| 4| 9| 3| 1| 0| 3| 3| 3| 3| 3| 2| 2| 3| 3| 3|
| 2| 1| 0| 2| 2| 1| 2| 2| 2| 6| 9| 3| 1| 4| 6| 1| 1| 1| 1| 0| 5| 2| 0| 1| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|
2200 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Hyperplasia | |
Pelvis, Transitional Epithelium, | |
Mineralization | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Muscularis, Hyperplasia | |
__________________________________________|__________________________________________________________________________
Page 40
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
__________________________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 7| 6| 6| 5| 7| 6| 6| 6| 7| 6| 7| 7| 6| 4| 7| 7| 7| 2| 5| 7| |
DAY ON TEST | 0| 8| 3| 3| 3| 3| 1| 9| 2| 3| 4| 7| 9| 3| 5| 3| 3| 2| 5| 2| 3| 1| 8| 3| 3| |
| 9| 9| 1| 1| 0| 2| 1| 4| 2| 2| 7| 4| 6| 2| 6| 0| 1| 1| 1| 2| 0| 8| 5| 7| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A |
2200 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A + + + + + +| 48 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 3 | 2 2.5|
Basophilic Focus | | 1 1.0|
Clear Cell Focus | | 2 1.0|
Clear Cell Focus, Multiple | | 1 3.0|
Hepatodiaphragmatic Nodule | 1 4 4 4 4| 6 3.5|
Vacuolization Cytoplasmic | 1 | 1 1.0|
Hepatocyte, Regeneration | 4 | 3 4.0|
Serosa, Fibrosis | | 1 3.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + + | 14 |
Necrosis | 2 2 3 3 3 3 3 | 13 2.9|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Thrombosis | | 1 4.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
__________________________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 7| 6| 6| 5| 7| 6| 6| 6| 7| 6| 7| 7| 6| 4| 7| 7| 7| 2| 5| 7| |
DAY ON TEST | 0| 8| 3| 3| 3| 3| 1| 9| 2| 3| 4| 7| 9| 3| 5| 3| 3| 2| 5| 2| 3| 1| 8| 3| 3| |
| 9| 9| 1| 1| 0| 2| 1| 4| 2| 2| 7| 4| 6| 2| 6| 0| 1| 1| 1| 2| 0| 8| 5| 7| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A |
2200 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Ulcer | 2 4 | 2 3.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Tongue | + | 1 |
Epithelium, Hyperplasia | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 1 | 2 1.5|
Atrium, Thrombosis | 3 | 1 3.0|
Myocardium, Degeneration | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | 4 | 2 3.5|
Vacuolization Cytoplasmic | 3 2 3 1 3 | 12 2.3|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | | 1 4.0|
Hyperplasia | 1 2 1 | 4 1.8|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 2 | 2 2.5|
Pars Distalis, Cyst | X X | 3 |
Pars Distalis, Hemorrhage | | 1 4.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
__________________________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 7| 6| 6| 5| 7| 6| 6| 6| 7| 6| 7| 7| 6| 4| 7| 7| 7| 2| 5| 7| |
DAY ON TEST | 0| 8| 3| 3| 3| 3| 1| 9| 2| 3| 4| 7| 9| 3| 5| 3| 3| 2| 5| 2| 3| 1| 8| 3| 3| |
| 9| 9| 1| 1| 0| 2| 1| 4| 2| 2| 7| 4| 6| 2| 6| 0| 1| 1| 1| 2| 0| 8| 5| 7| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A |
2200 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Pars Distalis, Hyperplasia | 3 3| 8 3.1|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 4 1 1 | 5 2.6|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | + + + + + + + + + + + + + + + + + + + +| 40 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 2.0|
Inflammation, Chronic | | 1 4.0|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 5 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Decidual Reaction | 4 | 1 4.0|
Degeneration | 4 | 1 4.0|
Hemorrhage | 4 4 | 3 4.0|
Necrosis | 4 4 | 2 4.0|
Prolapse | X | 1 |
Capillary, Myometrium, Hyperplasia | 4 | 1 4.0|
Endometrium, Hyperplasia | 3 | 1 3.0|
Endometrium, Inflammation, | | |
Suppurative | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node | + + | 4 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
__________________________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 7| 6| 6| 5| 7| 6| 6| 6| 7| 6| 7| 7| 6| 4| 7| 7| 7| 2| 5| 7| |
DAY ON TEST | 0| 8| 3| 3| 3| 3| 1| 9| 2| 3| 4| 7| 9| 3| 5| 3| 3| 2| 5| 2| 3| 1| 8| 3| 3| |
| 9| 9| 1| 1| 0| 2| 1| 4| 2| 2| 7| 4| 6| 2| 6| 0| 1| 1| 1| 2| 0| 8| 5| 7| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A |
2200 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M M M M M M M + M M + M M M M M M + M M M M + M| 11 |
Infiltration Cellular, Histiocyte | | 1 4.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M| |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Necrosis | | 1 4.0|
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + M + + + + + + + + + + + + + + + M| 45 |
Hemorrhage | | 1 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 1 3.0|
Hemorrhage | | 1 4.0|
Necrosis | 4 3 | 3 3.7|
Thrombosis | | 1 4.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + M| 48 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 4 1| 2 2.5|
Epithelium, Hyperplasia | | 1 3.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | | 1 4.0|
Inflammation, Chronic | | 1 1.0|
Ulcer | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
__________________________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 7| 6| 6| 5| 7| 6| 6| 6| 7| 6| 7| 7| 6| 4| 7| 7| 7| 2| 5| 7| |
DAY ON TEST | 0| 8| 3| 3| 3| 3| 1| 9| 2| 3| 4| 7| 9| 3| 5| 3| 3| 2| 5| 2| 3| 1| 8| 3| 3| |
| 9| 9| 1| 1| 0| 2| 1| 4| 2| 2| 7| 4| 6| 2| 6| 0| 1| 1| 1| 2| 0| 8| 5| 7| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A |
2200 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 3 3 | 6 2.8|
Hemorrhage | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Foreign Body | 4 | 1 4.0|
Epiglottis, Metaplasia, Squamous | | 1 2.0|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 | 1 2.0|
Necrosis | | 1 4.0|
Alveolar Epithelium, Hyperplasia | 1 1 | 3 1.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 1 2 1 1 2 2| 15 1.3|
Alveolus, Proteinosis | 1 | 1 1.0|
Bronchiole, Hyperplasia, Focal | | 1 2.0|
Interstitium, Fibrosis | 2 1 | 2 1.5|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Goblet Cell, Hyperplasia | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 3 | 1 3.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 1 2 2 1 3 2 1 2 1 1 2 1 2 | 28 1.5|
|__________________________________________________________________________|____________|
Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 1 1 1 1 2 1 1 1| 12 1.3|
Inflammation, Chronic | 2 2 1 2| 5 1.6|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 45
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
__________________________________________________________________________________________________________________________________
| 5| 5| 7| 7| 7| 7| 6| 6| 5| 7| 6| 6| 6| 7| 6| 7| 7| 6| 4| 7| 7| 7| 2| 5| 7| |
DAY ON TEST | 0| 8| 3| 3| 3| 3| 1| 9| 2| 3| 4| 7| 9| 3| 5| 3| 3| 2| 5| 2| 3| 1| 8| 3| 3| |
| 9| 9| 1| 1| 0| 2| 1| 4| 2| 2| 7| 4| 6| 2| 6| 0| 1| 1| 1| 2| 0| 8| 5| 7| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| A |
2200 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | + | 1 |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lens, Cataract | 4 4 | 4 3.8|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 |
Nephropathy, Chronic | 3 1 1 3 1 3 2 3 2 2 2 3 2 2 2 1 2 1 2 1| 44 1.8|
Cortex, Inflammation, Suppurative | | 1 1.0|
Cortex, Renal Tubule, Accumulation, | | |
Hyaline Droplet | | 1 3.0|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | 2 1 2 | 3 1.7|
Pelvis, Transitional Epithelium, | | |
Mineralization | 3 1 2 1 1 2 1 1 2 1 1 1 1| 27 1.2|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Muscularis, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 6| 7| 4| 6| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 2| 3| 2| 0| 2| 7| 2| 2| 2| 1| 9| 1| 1| 7| 9| 2| 2| 2| 3| 7| 2| 2|
| 0| 0| 0| 9| 0| 9| 5| 1| 0| 9| 9| 9| 7| 6| 1| 6| 6| 1| 9| 9| 9| 0| 4| 6| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 2 |
Clear Cell Focus | 2 1 1 1 |
Hemorrhage | |
Hepatodiaphragmatic Nodule | 4 4 4|
Inflammation, Granulomatous | 2 |
Necrosis | 3 |
Vacuolization Cytoplasmic | 4 3 |
Periportal, Pigmentation | X |
|__________________________________________________________________________|
Mesentery | + + + + + |
Necrosis | 3 2 2 3 2 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 4 2 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 3 |
Ulcer | 4 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 47
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 6| 7| 4| 6| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 2| 3| 2| 0| 2| 7| 2| 2| 2| 1| 9| 1| 1| 7| 9| 2| 2| 2| 3| 7| 2| 2|
| 0| 0| 0| 9| 0| 9| 5| 1| 0| 9| 9| 9| 7| 6| 1| 6| 6| 1| 9| 9| 9| 0| 4| 6| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Tongue | + |
Epithelium, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2 1 1 |
Atrium, Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 1 |
Vacuolization Cytoplasmic | 2 1 X 1 2 1 1 1 3 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 1 2 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia | 3 4|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 3 4 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Peritoneum | + + + + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 48
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 6| 7| 4| 6| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 2| 3| 2| 0| 2| 7| 2| 2| 2| 1| 9| 1| 1| 7| 9| 2| 2| 2| 3| 7| 2| 2|
| 0| 0| 0| 9| 0| 9| 5| 1| 0| 9| 9| 9| 7| 6| 1| 6| 6| 1| 9| 9| 9| 0| 4| 6| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
|__________________________________________________________________________|
Coagulating Gland | + + |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation, Suppurative | 2 3 2 2 4 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic Active | 3 2 |
Germinal Epithelium, Atrophy | 4 4 4 4 4 3 4 4 4 4 4 |
Interstitial Cell, Hyperplasia | 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + |
Pancreatic, Angiectasis | |
Pancreatic, Ectasia | 4 |
|__________________________________________________________________________|
Lymph Node, Bronchial | M + M M M M M M + + M M M + M M M M M + M M + + M|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Histiocyte | |
Pigmentation | 2 |
|__________________________________________________________________________|
Lymph Node, Mandibular | M + M M M M M M M M M M M M M M M M M M M M M M M|
Hematopoietic Cell Proliferation | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 49
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 6| 7| 4| 6| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 2| 3| 2| 0| 2| 7| 2| 2| 2| 1| 9| 1| 1| 7| 9| 2| 2| 2| 3| 7| 2| 2|
| 0| 0| 0| 9| 0| 9| 5| 1| 0| 9| 9| 9| 7| 6| 1| 6| 6| 1| 9| 9| 9| 0| 4| 6| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mediastinal | + M + M + + + + + + + + + M + + + + + + + + M M +|
Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | X |
Fibrosis | 3 |
Hematopoietic Cell Proliferation | |
Hemorrhage | 4 |
Necrosis | 3 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + M + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 4 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | 4 4 |
Hyperkeratosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 |
Rib, Cartilage, Degeneration | 3 |
|__________________________________________________________________________|
Skeletal Muscle | |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 3 3 3 3 3 |
Hemorrhage | 3 2 4 4 |
__________________________________________|__________________________________________________________________________|
Page 50
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 6| 7| 4| 6| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 2| 3| 2| 0| 2| 7| 2| 2| 2| 1| 9| 1| 1| 7| 9| 2| 2| 2| 3| 7| 2| 2|
| 0| 0| 0| 9| 0| 9| 5| 1| 0| 9| 9| 9| 7| 6| 1| 6| 6| 1| 9| 9| 9| 0| 4| 6| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 4 |
Alveolar Epithelium, Hyperplasia | 3 1 1 1 1 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 1 1 2 1 4 |
Interstitium, Fibrosis | 4 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Suppurative | 4 |
Glands, Hyperplasia | |
Goblet Cell, Hyperplasia | |
Nasolacrimal Duct, Inflammation, | |
Suppurative | |
Olfactory Epithelium, Degeneration, | |
Hyaline | 3 |
Respiratory Epithelium, Hyperplasia | 4 1 |
Turbinate, Necrosis | 3 |
|__________________________________________________________________________|
Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 |
Inflammation, Chronic | 1 2 2 1 1 1 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Lens, Cataract | 3 3 3 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 51
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 6| 7| 4| 6| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 2| 3| 2| 0| 2| 7| 2| 2| 2| 1| 9| 1| 1| 7| 9| 2| 2| 2| 3| 7| 2| 2|
| 0| 0| 0| 9| 0| 9| 5| 1| 0| 9| 9| 9| 7| 6| 1| 6| 6| 1| 9| 9| 9| 0| 4| 6| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 2 2 1 2 2 2 2 4 2 2 2 2 2 3 2 3 1 2 2 1 1 2 3 4 2|
Cortex, Infarct | 3 |
Cortex, Renal Tubule, Accumulation, | |
Hyaline Droplet | 3 |
Papilla, Mineralization | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 52
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 5| 6| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 3| 7| 2| 7| 1| 7| 5| 2| 7| 3| 1| 3| 2| 1| 3| 2| 3| 2| 8| 2| |
| 9| 9| 9| 9| 9| 0| 0| 9| 6| 1| 4| 6| 9| 0| 0| 2| 0| 9| 2| 0| 9| 0| 6| 4| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + A + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | | 1 2.0|
Clear Cell Focus | 3 1 | 6 1.5|
Hemorrhage | 3 | 1 3.0|
Hepatodiaphragmatic Nodule | 4 4 4 4| 7 4.0|
Inflammation, Granulomatous | | 1 2.0|
Necrosis | | 1 3.0|
Vacuolization Cytoplasmic | 3 | 3 3.3|
Periportal, Pigmentation | | 1 |
|__________________________________________________________________________|____________|
Mesentery | + + | 7 |
Necrosis | 3 3 | 7 2.6|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | | 2 3.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 5| 6| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 3| 7| 2| 7| 1| 7| 5| 2| 7| 3| 1| 3| 2| 1| 3| 2| 3| 2| 8| 2| |
| 9| 9| 9| 9| 9| 0| 0| 9| 6| 1| 4| 6| 9| 0| 0| 2| 0| 9| 2| 0| 9| 0| 6| 4| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Hyperplasia, Squamous | | 1 3.0|
Ulcer | 4 | 2 4.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Tongue | | 1 |
Epithelium, Hyperplasia | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 3 1 2 2 1 1 1| 13 1.5|
Atrium, Thrombosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | | 1 1.0|
Vacuolization Cytoplasmic | 1 1 2 1 4 1 | 15 1.6|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 3 1 3 2 3 4 4| 12 2.5|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 3.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Cyst | X | 1 |
Pars Distalis, Hyperplasia | 3 2 | 4 3.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 5| 6| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 3| 7| 2| 7| 1| 7| 5| 2| 7| 3| 1| 3| 2| 1| 3| 2| 3| 2| 8| 2| |
| 9| 9| 9| 9| 9| 0| 0| 9| 6| 1| 4| 6| 9| 0| 0| 2| 0| 9| 2| 0| 9| 0| 6| 4| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 1 3 1 2 2| 8 2.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | + + + + + + + + + | 14 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Coagulating Gland | | 2 |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 1 |
Hyperplasia | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
Inflammation, Suppurative | 1 2 3 2 3 | 10 2.4|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Inflammation, Chronic Active | | 2 2.5|
Germinal Epithelium, Atrophy | | 11 3.9|
Interstitial Cell, Hyperplasia | 3 3 3 | 5 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node | + + + + + | 7 |
Pancreatic, Angiectasis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 5| 6| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 3| 7| 2| 7| 1| 7| 5| 2| 7| 3| 1| 3| 2| 1| 3| 2| 3| 2| 8| 2| |
| 9| 9| 9| 9| 9| 0| 0| 9| 6| 1| 4| 6| 9| 0| 0| 2| 0| 9| 2| 0| 9| 0| 6| 4| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Pancreatic, Ectasia | | 1 4.0|
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M M + M + M M M M + M + + M + M M M M M M + M M| 15 |
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Hyperplasia, Lymphoid | 3 | 1 3.0|
Infiltration Cellular, Histiocyte | 2 | 1 2.0|
Pigmentation | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M + M M M M M M M M M| 2 |
Hematopoietic Cell Proliferation | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + M + + + + + M + + + + + + + M +| 42 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Spleen | | 1 |
Fibrosis | 4 | 2 3.5|
Hematopoietic Cell Proliferation | 4 | 1 4.0|
Hemorrhage | 2 | 2 3.0|
Necrosis | 4 4 | 3 3.7|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 4 4 | 3 4.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | 4 4 4 | 5 4.0|
Hyperkeratosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 5| 6| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 3| 7| 2| 7| 1| 7| 5| 2| 7| 3| 1| 3| 2| 1| 3| 2| 3| 2| 8| 2| |
| 9| 9| 9| 9| 9| 0| 0| 9| 6| 1| 4| 6| 9| 0| 0| 2| 0| 9| 2| 0| 9| 0| 6| 4| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | | 1 3.0|
Rib, Cartilage, Degeneration | | 1 3.0|
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
Hemorrhage | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 3 3 3 2 4 2 4 | 13 3.1|
Hemorrhage | | 4 3.3|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 2 1 | 5 2.0|
Alveolar Epithelium, Hyperplasia | 1 1 1 4| 10 1.5|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 2 1 1 1 1 | 13 1.4|
Interstitium, Fibrosis | | 1 4.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 3 3 | 2 3.0|
Inflammation, Suppurative | 3 2 2 | 4 2.8|
Glands, Hyperplasia | 3 | 1 3.0|
Goblet Cell, Hyperplasia | 3 | 1 3.0|
Nasolacrimal Duct, Inflammation, | | |
Suppurative | 2| 1 2.0|
Olfactory Epithelium, Degeneration, | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 7| 5| 6| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| |
DAY ON TEST | 2| 2| 2| 2| 2| 3| 7| 2| 7| 1| 7| 5| 2| 7| 3| 1| 3| 2| 1| 3| 2| 3| 2| 8| 2| |
| 9| 9| 9| 9| 9| 0| 0| 9| 6| 1| 4| 6| 9| 0| 0| 2| 0| 9| 2| 0| 9| 0| 6| 4| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Hyaline | 1 | 2 2.0|
Respiratory Epithelium, Hyperplasia | 1 3 | 4 2.3|
Turbinate, Necrosis | | 1 3.0|
|__________________________________________________________________________|____________|
Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 1 | 2 1.0|
Inflammation, Chronic | 2 2 1 1 1 | 11 1.4|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 | 1 4.0|
Lens, Cataract | 3 3 4 | 6 3.2|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 1 2 1 2 2 2 2 2 3 3 1 1 2 2 2 2 2 2 1 2 3 2 1 3 3| 50 2.0|
Cortex, Infarct | 4 | 2 3.5|
Cortex, Renal Tubule, Accumulation, | | |
Hyaline Droplet | 2 | 2 2.5|
Papilla, Mineralization | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 7| 4| 5| 5| 7| 6| 7| 7| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 2| 2| 7| 2| 2| 0| 6| 7| 3| 4| 3| 2| 5| 7| 0| 4| 2| 3| 5| 2| 3| 2| 8| 2|
| 0| 1| 9| 0| 9| 9| 3| 5| 9| 0| 2| 0| 9| 2| 0| 5| 2| 5| 6| 6| 9| 0| 9| 2| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
138 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 4 |
Epithelium, Cyst | |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | 2 |
Hepatodiaphragmatic Nodule | 4 |
Inflammation, Granulomatous | 2 |
Vacuolization Cytoplasmic | 4 |
|__________________________________________________________________________|
Mesentery | + + + + + + + + |
Necrosis | 3 3 3 2 2 4 3 2 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | 3 3 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 4 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 4 |
Mineralization | 4 |
Ulcer | |
__________________________________________|__________________________________________________________________________|
Page 59
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 7| 4| 5| 5| 7| 6| 7| 7| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 2| 2| 7| 2| 2| 0| 6| 7| 3| 4| 3| 2| 5| 7| 0| 4| 2| 3| 5| 2| 3| 2| 8| 2|
| 0| 1| 9| 0| 9| 9| 3| 5| 9| 0| 2| 0| 9| 2| 0| 5| 2| 5| 6| 6| 9| 0| 9| 2| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
138 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Tongue | + |
Epithelium, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 4 |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 4 1 |
Artery, Mineralization | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 2 |
Vacuolization Cytoplasmic | 3 4 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 2 1 3 4 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hemorrhage | 2 |
Pars Distalis, Hyperplasia | 2 3 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 3 2 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Peritoneum | + + + + + + + + + + + + + + + + + + + + |
__________________________________________|__________________________________________________________________________|
Page 60
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 7| 4| 5| 5| 7| 6| 7| 7| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 2| 2| 7| 2| 2| 0| 6| 7| 3| 4| 3| 2| 5| 7| 0| 4| 2| 3| 5| 2| 3| 2| 8| 2|
| 0| 1| 9| 0| 9| 9| 3| 5| 9| 0| 2| 0| 9| 2| 0| 5| 2| 5| 6| 6| 9| 0| 9| 2| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
138 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hyperplasia | 4 |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Inflammation, Suppurative | 1 3 2 3 3 1|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic Active | 3 |
Germinal Epithelium, Atrophy | 4 4 3 3 |
Interstitial Cell, Hyperplasia | 3 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + + + + +|
Deep Cervical, Ectasia | |
Pancreatic, Infiltration Cellular, | |
Histiocyte | |
Pancreatic, Pigmentation | |
|__________________________________________________________________________|
Lymph Node, Bronchial | + M + + M + M M M M + M + M + M M M M + M M M M M|
Infiltration Cellular, Histiocyte | 3 |
Pigmentation | 3 |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 4 |
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + M + M + + + + + + + + M M + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 61
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 7| 4| 5| 5| 7| 6| 7| 7| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 2| 2| 7| 2| 2| 0| 6| 7| 3| 4| 3| 2| 5| 7| 0| 4| 2| 3| 5| 2| 3| 2| 8| 2|
| 0| 1| 9| 0| 9| 9| 3| 5| 9| 0| 2| 0| 9| 2| 0| 5| 2| 5| 6| 6| 9| 0| 9| 2| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
138 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Hyperplasia, Lymphoid | 3 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 4 4 |
Hemorrhage | |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + M + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 3 |
Hyperplasia | |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 4 4 3 2 3 3 |
Hemorrhage | 2 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 4 |
Inflammation, Suppurative | 3 |
Epiglottis, Metaplasia, Squamous | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 62
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 7| 4| 5| 5| 7| 6| 7| 7| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 2| 2| 7| 2| 2| 0| 6| 7| 3| 4| 3| 2| 5| 7| 0| 4| 2| 3| 5| 2| 3| 2| 8| 2|
| 0| 1| 9| 0| 9| 9| 3| 5| 9| 0| 2| 0| 9| 2| 0| 5| 2| 5| 6| 6| 9| 0| 9| 2| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
138 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Hemorrhage | 2 2 1 |
Alveolar Epithelium, Hyperplasia | 4 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 2 2 3 3 2 2 |
Alveolus, Mineralization | 4 |
Alveolus, Proteinosis | 2 |
Interstitium, Fibrosis | 1 2 1|
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 3 3 |
Inflammation, Suppurative | 3 2 |
Goblet Cell, Hyperplasia | |
Olfactory Epithelium, Degeneration, | |
Hyaline | 2 1 1 |
Respiratory Epithelium, Hyperplasia | 3 |
|__________________________________________________________________________|
Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 1 1 2 1 3 1 2 2 |
Inflammation, Chronic | 3 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 3 |
Lens, Cataract | 2 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 3 3 2 2 3 2 2 3 3 2 1 2 2 4 1 3 2 1 3 1 1 3 3 3 |
Cortex, Infarct | 4|
Cortex, Renal Tubule, Accumulation, | |
Hyaline Droplet | 4 1 4 |
Cortex, Renal Tubule, Casts Granular | 3 |
__________________________________________|__________________________________________________________________________|
Page 63
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
_____________________________________________________________________________________________________________________
| 7| 6| 7| 6| 7| 7| 4| 5| 5| 7| 6| 7| 7| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 6| 4|
DAY ON TEST | 3| 2| 2| 7| 2| 2| 0| 6| 7| 3| 4| 3| 2| 5| 7| 0| 4| 2| 3| 5| 2| 3| 2| 8| 2|
| 0| 1| 9| 0| 9| 9| 3| 5| 9| 0| 2| 0| 9| 2| 0| 5| 2| 5| 6| 6| 9| 0| 9| 2| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
138 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Cortex, Renal Tubule, Hyperplasia | |
Medulla, Casts Granular | |
Papilla, Mineralization | 1 1 1 1 |
Papilla, Necrosis | 4 |
Pelvis, Dilatation | 4 |
Pelvis, Transitional Epithelium, | |
Hyperplasia | 2 |
Renal Tubule, Mineralization | 4 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Inflammation, Chronic | 4 |
Muscularis, Transitional Epithelium, | |
Mineralization | 4 |
__________________________________________|__________________________________________________________________________
Page 64
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 5| 7| 7| 6| 4| 6| 6| 6| 6| 7| 7| 6| 7| 7| 5| 5| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 5| 4| 5| 8| 2| 2| 7| 7| 4| 6| 4| 7| 2| 3| 4| 2| 2| 3| 9| 2| 2| 2| 3| 2| 2| |
| 6| 2| 8| 2| 9| 9| 0| 2| 2| 7| 2| 1| 9| 0| 0| 9| 9| 7| 0| 9| 1| 1| 0| 9| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
138 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + + + + + + +| 49 |
Necrosis | | 1 4.0|
Epithelium, Cyst | X | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + A + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + A + + A + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Clear Cell Focus | 2 1 1 | 4 1.5|
Hepatodiaphragmatic Nodule | 4 4 | 3 4.0|
Inflammation, Granulomatous | | 1 2.0|
Vacuolization Cytoplasmic | 1 2 | 3 2.3|
|__________________________________________________________________________|____________|
Mesentery | + + + | 11 |
Necrosis | 3 3 3 | 11 2.8|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | | 2 3.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | 4 4 | 3 4.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 5| 7| 7| 6| 4| 6| 6| 6| 6| 7| 7| 6| 7| 7| 5| 5| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 5| 4| 5| 8| 2| 2| 7| 7| 4| 6| 4| 7| 2| 3| 4| 2| 2| 3| 9| 2| 2| 2| 3| 2| 2| |
| 6| 2| 8| 2| 9| 9| 0| 2| 2| 7| 2| 1| 9| 0| 0| 9| 9| 7| 0| 9| 1| 1| 0| 9| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
138 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | | 1 4.0|
Mineralization | | 1 4.0|
Ulcer | 3| 1 3.0|
|__________________________________________________________________________|____________|
Tongue | | 1 |
Epithelium, Hyperplasia | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | | 1 4.0|
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 | 4 2.3|
Artery, Mineralization | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | | 1 2.0|
Vacuolization Cytoplasmic | 2 2 2 | 5 2.6|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 3 3 3 3 3 3 2 1 | 14 2.6|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Hemorrhage | | 1 2.0|
Pars Distalis, Hyperplasia | 4 2 4 | 5 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 5| 7| 7| 6| 4| 6| 6| 6| 6| 7| 7| 6| 7| 7| 5| 5| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 5| 4| 5| 8| 2| 2| 7| 7| 4| 6| 4| 7| 2| 3| 4| 2| 2| 3| 9| 2| 2| 2| 3| 2| 2| |
| 6| 2| 8| 2| 9| 9| 0| 2| 2| 7| 2| 1| 9| 0| 0| 9| 9| 7| 0| 9| 1| 1| 0| 9| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
138 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 4 | 4 2.8|
Follicular Cell, Hyperplasia | 3| 1 3.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | + + + + + + + + + + + + + + + + + + + + +| 41 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 |
Hyperplasia | | 1 4.0|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 3.0|
Inflammation, Suppurative | 1 1 2 3 | 10 2.0|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Inflammation, Chronic Active | 2 | 2 2.5|
Germinal Epithelium, Atrophy | 4 2 4 4 4| 9 3.6|
Interstitial Cell, Hyperplasia | 1 3 | 4 2.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + | 16 |
Deep Cervical, Ectasia | 4 | 1 4.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 5| 7| 7| 6| 4| 6| 6| 6| 6| 7| 7| 6| 7| 7| 5| 5| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 5| 4| 5| 8| 2| 2| 7| 7| 4| 6| 4| 7| 2| 3| 4| 2| 2| 3| 9| 2| 2| 2| 3| 2| 2| |
| 6| 2| 8| 2| 9| 9| 0| 2| 2| 7| 2| 1| 9| 0| 0| 9| 9| 7| 0| 9| 1| 1| 0| 9| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
138 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Pancreatic, Infiltration Cellular, | | |
Histiocyte | 4 | 1 4.0|
Pancreatic, Pigmentation | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | M M + + M M M M M M M M + M M M M M M M M M M M +| 12 |
Infiltration Cellular, Histiocyte | | 1 3.0|
Pigmentation | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M| |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | | 1 4.0|
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + M + + + + + + + M + + + + + + +| 44 |
Hyperplasia, Lymphoid | | 1 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3 | 3 3.7|
Hemorrhage | 4 4 | 2 4.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 4 | 2 3.5|
Hyperplasia | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | 4 | 2 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 5| 7| 7| 6| 4| 6| 6| 6| 6| 7| 7| 6| 7| 7| 5| 5| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 5| 4| 5| 8| 2| 2| 7| 7| 4| 6| 4| 7| 2| 3| 4| 2| 2| 3| 9| 2| 2| 2| 3| 2| 2| |
| 6| 2| 8| 2| 9| 9| 0| 2| 2| 7| 2| 1| 9| 0| 0| 9| 9| 7| 0| 9| 1| 1| 0| 9| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
138 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
Hyperostosis | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 4 4 2 4 3 3 3 3 | 15 3.3|
Hemorrhage | 4 3 | 4 3.3|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 4 | 2 4.0|
Inflammation, Suppurative | 3 | 2 3.0|
Epiglottis, Metaplasia, Squamous | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 2 | 5 2.0|
Alveolar Epithelium, Hyperplasia | 2 1 | 3 2.3|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 1 1 2 | 11 1.8|
Alveolus, Mineralization | | 1 4.0|
Alveolus, Proteinosis | | 1 2.0|
Interstitium, Fibrosis | 2 1 | 5 1.4|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 3 | 3 3.0|
Inflammation, Suppurative | 3 2 | 4 2.5|
Goblet Cell, Hyperplasia | 1 | 1 1.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 1 1 2 1 | 8 1.3|
Respiratory Epithelium, Hyperplasia | | 1 3.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 5| 7| 7| 6| 4| 6| 6| 6| 6| 7| 7| 6| 7| 7| 5| 5| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 5| 4| 5| 8| 2| 2| 7| 7| 4| 6| 4| 7| 2| 3| 4| 2| 2| 3| 9| 2| 2| 2| 3| 2| 2| |
| 6| 2| 8| 2| 9| 9| 0| 2| 2| 7| 2| 1| 9| 0| 0| 9| 9| 7| 0| 9| 1| 1| 0| 9| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
138 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 1 2 2 | 12 1.6|
Inflammation, Chronic | | 2 2.5|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 1 3.0|
Lens, Cataract | | 1 2.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 3 2 2 3 4 4 1 2 1 2 1 1 4 3 2 2 4 1 1 2 1 3 3 3 3| 49 2.3|
Cortex, Infarct | | 1 4.0|
Cortex, Renal Tubule, Accumulation, | | |
Hyaline Droplet | 2 4 | 5 3.0|
Cortex, Renal Tubule, Casts Granular | | 1 3.0|
Cortex, Renal Tubule, Hyperplasia | 3| 1 3.0|
Medulla, Casts Granular | 2 2 2| 3 2.0|
Papilla, Mineralization | 1 1 2 1 | 8 1.1|
Papilla, Necrosis | | 1 4.0|
Pelvis, Dilatation | | 1 4.0|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | 2 | 2 2.0|
Renal Tubule, Mineralization | | 1 4.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 4.0|
Inflammation, Chronic | | 1 4.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 5| 7| 7| 6| 4| 6| 6| 6| 6| 7| 7| 6| 7| 7| 5| 5| 7| 6| 6| 7| 7| 7| |
DAY ON TEST | 5| 4| 5| 8| 2| 2| 7| 7| 4| 6| 4| 7| 2| 3| 4| 2| 2| 3| 9| 2| 2| 2| 3| 2| 2| |
| 6| 2| 8| 2| 9| 9| 0| 2| 2| 7| 2| 1| 9| 0| 0| 9| 9| 7| 0| 9| 1| 1| 0| 9| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
138 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Muscularis, Transitional Epithelium, | | |
Mineralization | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 6| 7| 7| 5| 6| 6| 5|
DAY ON TEST | 3| 0| 0| 7| 2| 2| 1| 4| 2| 3| 2| 3| 4| 2| 9| 3| 4| 2| 3| 1| 3| 0| 9| 7| 8|
| 0| 2| 8| 5| 9| 9| 5| 2| 9| 0| 6| 0| 7| 9| 1| 0| 1| 0| 3| 7| 0| 9| 6| 3| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
550 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + + + + + + + + + + + + + + + + A +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + + + + + + A +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + + A + + + + + + + + + + A +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + + + + A + + + + + + + + + + A +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Clear Cell Focus | 4 X |
Hepatodiaphragmatic Nodule | 4 4 4 |
Vacuolization Cytoplasmic | 4 |
Bile Duct, Hyperplasia | 2 |
Periportal, Pigmentation | |
|__________________________________________________________________________|
Mesentery | + + + + + |
Necrosis | 3 3 3 3 3 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + A +|
Hyperplasia, Squamous | 3 |
Ulcer | 4 4 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + A +|
Erosion | 3 2 |
Hyperplasia | |
__________________________________________|__________________________________________________________________________|
Page 72
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 6| 7| 7| 5| 6| 6| 5|
DAY ON TEST | 3| 0| 0| 7| 2| 2| 1| 4| 2| 3| 2| 3| 4| 2| 9| 3| 4| 2| 3| 1| 3| 0| 9| 7| 8|
| 0| 2| 8| 5| 9| 9| 5| 2| 9| 0| 6| 0| 7| 9| 1| 0| 1| 0| 3| 7| 0| 9| 6| 3| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
550 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Ulcer | 3 |
|__________________________________________________________________________|
Tongue | + + |
Epithelium, Hyperkeratosis | 3 |
Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 3 1 |
Atrium, Thrombosis | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 |
Necrosis | 3 |
Vacuolization Cytoplasmic | 1 2 4 2 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 2 3 2 3 2 1 3 3 3 4 4 3 |
Thrombosis | 4 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hemorrhage | 4 |
Pars Distalis, Hyperplasia | 2 2 2 4 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 73
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 6| 7| 7| 5| 6| 6| 5|
DAY ON TEST | 3| 0| 0| 7| 2| 2| 1| 4| 2| 3| 2| 3| 4| 2| 9| 3| 4| 2| 3| 1| 3| 0| 9| 7| 8|
| 0| 2| 8| 5| 9| 9| 5| 2| 9| 0| 6| 0| 7| 9| 1| 0| 1| 0| 3| 7| 0| 9| 6| 3| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
550 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
|__________________________________________________________________________|
Peritoneum | + + + + + + + + + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation, Suppurative | 3 |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 3 2 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic Active | 3 |
Germinal Epithelium, Atrophy | 1 3 4 4 3 4 4 3 |
Interstitial Cell, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Myeloid Cell, Hyperplasia | |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + |
Pancreatic, Ectasia | 4 |
|__________________________________________________________________________|
Lymph Node, Bronchial | M M M M M M + M + M M M + M M M + M M + + M M M +|
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 3 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 74
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 6| 7| 7| 5| 6| 6| 5|
DAY ON TEST | 3| 0| 0| 7| 2| 2| 1| 4| 2| 3| 2| 3| 4| 2| 9| 3| 4| 2| 3| 1| 3| 0| 9| 7| 8|
| 0| 2| 8| 5| 9| 9| 5| 2| 9| 0| 6| 0| 7| 9| 1| 0| 1| 0| 3| 7| 0| 9| 6| 3| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
550 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Lymph Node, Mediastinal | M + + M + + + + + M + M + M + + + + + + M + + + +|
Angiectasis | |
Hyperplasia, Lymphoid | |
Infiltration Cellular | |
Pigmentation | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | X X X |
Fibrosis | 3 3 4 |
Hematopoietic Cell Proliferation | 4 |
Hemorrhage | 4 4 |
Necrosis | 4 4 4|
Thrombosis | 4 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + M + M + + + + + + + + + + + + +|
Thrombosis | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 4 4 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | 1 |
Hyperkeratosis | 3 |
Inflammation, Chronic | 3 |
Inflammation, Granulomatous | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
|__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 75
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 6| 7| 7| 5| 6| 6| 5|
DAY ON TEST | 3| 0| 0| 7| 2| 2| 1| 4| 2| 3| 2| 3| 4| 2| 9| 3| 4| 2| 3| 1| 3| 0| 9| 7| 8|
| 0| 2| 8| 5| 9| 9| 5| 2| 9| 0| 6| 0| 7| 9| 1| 0| 1| 0| 3| 7| 0| 9| 6| 3| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
550 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
Compression | 4 4 3 3 3 |
Hemorrhage | 3 3 4 4 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 4 |
Inflammation, Chronic | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 2 4 3 |
Alveolar Epithelium, Hyperplasia | 3 |
Alveolar Epithelium, Metaplasia, | |
Squamous | 3 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 2 1 2 |
Interstitium, Fibrosis | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Suppurative | 2|
Goblet Cell, Hyperplasia | 3 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 2 |
Respiratory Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Inflammation, Chronic | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + A +|
Lens, Cataract | 3 4 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 76
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 6| 7| 7| 5| 6| 6| 5|
DAY ON TEST | 3| 0| 0| 7| 2| 2| 1| 4| 2| 3| 2| 3| 4| 2| 9| 3| 4| 2| 3| 1| 3| 0| 9| 7| 8|
| 0| 2| 8| 5| 9| 9| 5| 2| 9| 0| 6| 0| 7| 9| 1| 0| 1| 0| 3| 7| 0| 9| 6| 3| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
550 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic | 2 3 2 2 3 4 2 2 4 4 4 2 2 2 2 2 2 3 4 2 3 1 2 2 3|
Cortex, Infarct | |
Cortex, Renal Tubule, Accumulation, | |
Hyaline Droplet | |
Cortex, Renal Tubule, Casts Granular | |
Cortex, Renal Tubule, Hyperplasia | 3 2 2 |
Medulla, Casts Granular | 1|
Papilla, Mineralization | 3 1 2 2 3 1 1 2 1 1 1 2 2 1 3 2|
Pelvis, Dilatation | |
Pelvis, Transitional Epithelium, | |
Hyperplasia | 4 2 2 1 1 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
__________________________________________|__________________________________________________________________________
Page 77
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
__________________________________________________________________________________________________________________________________
| 7| 7| 3| 7| 7| 7| 7| 5| 7| 7| 5| 5| 7| 7| 5| 7| 6| 6| 6| 5| 7| 7| 7| 7| 6| |
DAY ON TEST | 2| 2| 9| 2| 1| 3| 2| 5| 2| 2| 5| 4| 2| 3| 2| 2| 9| 2| 1| 9| 2| 0| 2| 1| 7| |
| 9| 9| 6| 9| 2| 0| 9| 8| 9| 9| 6| 6| 9| 0| 9| 9| 8| 1| 8| 3| 9| 5| 9| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
550 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + A +| 46 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + A +| 46 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Clear Cell Focus | 2 | 3 3.0|
Hepatodiaphragmatic Nodule | 4 4 | 5 4.0|
Vacuolization Cytoplasmic | | 1 4.0|
Bile Duct, Hyperplasia | 3 4 | 3 3.0|
Periportal, Pigmentation | 4 4 | 2 4.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + | 11 |
Necrosis | 3 3 3 3 3 3 | 11 3.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Squamous | | 1 3.0|
Ulcer | | 2 4.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
__________________________________________________________________________________________________________________________________
| 7| 7| 3| 7| 7| 7| 7| 5| 7| 7| 5| 5| 7| 7| 5| 7| 6| 6| 6| 5| 7| 7| 7| 7| 6| |
DAY ON TEST | 2| 2| 9| 2| 1| 3| 2| 5| 2| 2| 5| 4| 2| 3| 2| 2| 9| 2| 1| 9| 2| 0| 2| 1| 7| |
| 9| 9| 6| 9| 2| 0| 9| 8| 9| 9| 6| 6| 9| 0| 9| 9| 8| 1| 8| 3| 9| 5| 9| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
550 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Erosion | 3 | 3 2.7|
Hyperplasia | 2 | 1 2.0|
Ulcer | | 1 3.0|
|__________________________________________________________________________|____________|
Tongue | + | 3 |
Epithelium, Hyperkeratosis | | 1 3.0|
Epithelium, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 | 5 2.0|
Atrium, Thrombosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | | 1 3.0|
Necrosis | | 1 3.0|
Vacuolization Cytoplasmic | 2 1 1 2 4 2 3 2 2 | 14 2.1|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 2 1 1 2 2 4 3 2 | 23 2.6|
Thrombosis | | 1 4.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
__________________________________________________________________________________________________________________________________
| 7| 7| 3| 7| 7| 7| 7| 5| 7| 7| 5| 5| 7| 7| 5| 7| 6| 6| 6| 5| 7| 7| 7| 7| 6| |
DAY ON TEST | 2| 2| 9| 2| 1| 3| 2| 5| 2| 2| 5| 4| 2| 3| 2| 2| 9| 2| 1| 9| 2| 0| 2| 1| 7| |
| 9| 9| 6| 9| 2| 0| 9| 8| 9| 9| 6| 6| 9| 0| 9| 9| 8| 1| 8| 3| 9| 5| 9| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
550 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hemorrhage | | 1 4.0|
Pars Distalis, Hyperplasia | 3 3 | 6 2.7|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 4 3 | 6 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | + + + + + + + + + + + + + + + + + + +| 41 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 1 |
Inflammation, Suppurative | 3 2 4 | 4 3.0|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 1 3 1 2 1 3 2 2 1 2 2| 14 1.9|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Inflammation, Chronic Active | | 1 3.0|
Germinal Epithelium, Atrophy | 4 4 4 4 3 3 4| 15 3.5|
Interstitial Cell, Hyperplasia | 3 | 2 3.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
__________________________________________________________________________________________________________________________________
| 7| 7| 3| 7| 7| 7| 7| 5| 7| 7| 5| 5| 7| 7| 5| 7| 6| 6| 6| 5| 7| 7| 7| 7| 6| |
DAY ON TEST | 2| 2| 9| 2| 1| 3| 2| 5| 2| 2| 5| 4| 2| 3| 2| 2| 9| 2| 1| 9| 2| 0| 2| 1| 7| |
| 9| 9| 6| 9| 2| 0| 9| 8| 9| 9| 6| 6| 9| 0| 9| 9| 8| 1| 8| 3| 9| 5| 9| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
550 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Myeloid Cell, Hyperplasia | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + | 11 |
Pancreatic, Ectasia | | 1 4.0|
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + M M + M M M M M + M M M + M M + M M + + M + +| 16 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M| |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | 4 | 2 3.5|
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + + M + + + + + + + + + + + + +| 43 |
Angiectasis | 3 3 | 2 3.0|
Hyperplasia, Lymphoid | 3 | 1 3.0|
Infiltration Cellular | 3 | 1 3.0|
Pigmentation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Spleen | | 3 |
Fibrosis | 3 | 4 3.3|
Hematopoietic Cell Proliferation | 3 | 2 3.5|
Hemorrhage | 3 3 | 4 3.5|
Necrosis | | 3 4.0|
Thrombosis | | 1 4.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + M + + + + + + + + + + + + +| 47 |
Thrombosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 4 | 3 4.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 81
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
__________________________________________________________________________________________________________________________________
| 7| 7| 3| 7| 7| 7| 7| 5| 7| 7| 5| 5| 7| 7| 5| 7| 6| 6| 6| 5| 7| 7| 7| 7| 6| |
DAY ON TEST | 2| 2| 9| 2| 1| 3| 2| 5| 2| 2| 5| 4| 2| 3| 2| 2| 9| 2| 1| 9| 2| 0| 2| 1| 7| |
| 9| 9| 6| 9| 2| 0| 9| 8| 9| 9| 6| 6| 9| 0| 9| 9| 8| 1| 8| 3| 9| 5| 9| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
550 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | 4 | 2 2.5|
Hyperkeratosis | | 1 3.0|
Inflammation, Chronic | 3 | 2 3.0|
Inflammation, Granulomatous | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 3 3 3 3 4| 10 3.3|
Hemorrhage | 4 | 5 3.6|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 4 | 2 4.0|
Inflammation, Chronic | 3 3 | 2 3.0|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 4 | 6 3.2|
Alveolar Epithelium, Hyperplasia | 1 4 4 1 4 | 6 2.8|
Alveolar Epithelium, Metaplasia, | | |
Squamous | 1 | 2 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 3 2 | 7 1.7|
Interstitium, Fibrosis | 3 1 | 2 2.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 82
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
__________________________________________________________________________________________________________________________________
| 7| 7| 3| 7| 7| 7| 7| 5| 7| 7| 5| 5| 7| 7| 5| 7| 6| 6| 6| 5| 7| 7| 7| 7| 6| |
DAY ON TEST | 2| 2| 9| 2| 1| 3| 2| 5| 2| 2| 5| 4| 2| 3| 2| 2| 9| 2| 1| 9| 2| 0| 2| 1| 7| |
| 9| 9| 6| 9| 2| 0| 9| 8| 9| 9| 6| 6| 9| 0| 9| 9| 8| 1| 8| 3| 9| 5| 9| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
550 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 3 | 1 3.0|
Inflammation, Suppurative | 1 | 2 1.5|
Goblet Cell, Hyperplasia | | 1 3.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 | 2 1.5|
Respiratory Epithelium, Hyperplasia | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 1 2 2 1 2 | 5 1.6|
Inflammation, Chronic | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Lens, Cataract | 4 | 3 3.7|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic | 3 4 1 3 3 3 2 2 3 1 1 3 2 3 2 1 2 2 1 2 3 3 3 3 3| 50 2.5|
Cortex, Infarct | 3 | 1 3.0|
Cortex, Renal Tubule, Accumulation, | | |
Hyaline Droplet | 3 3 3 | 3 3.0|
Cortex, Renal Tubule, Casts Granular | 1 | 1 1.0|
Cortex, Renal Tubule, Hyperplasia | 4 1 1 2 3 | 8 2.3|
Medulla, Casts Granular | | 1 1.0|
Papilla, Mineralization | 1 4 3 1 2 3 3 1 1 1 1 3 2 2 | 30 1.9|
Pelvis, Dilatation | 4 | 1 4.0|
Pelvis, Transitional Epithelium, | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 83
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
__________________________________________________________________________________________________________________________________
| 7| 7| 3| 7| 7| 7| 7| 5| 7| 7| 5| 5| 7| 7| 5| 7| 6| 6| 6| 5| 7| 7| 7| 7| 6| |
DAY ON TEST | 2| 2| 9| 2| 1| 3| 2| 5| 2| 2| 5| 4| 2| 3| 2| 2| 9| 2| 1| 9| 2| 0| 2| 1| 7| |
| 9| 9| 6| 9| 2| 0| 9| 8| 9| 9| 6| 6| 9| 0| 9| 9| 8| 1| 8| 3| 9| 5| 9| 5| 5| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| A |
550 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Hyperplasia | 2 1 4 | 8 2.1|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 84
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 6| 7| 6| 7| 5| 5| 5| 7| 7| 5| 7| 7| 6| 7| 7| 5| 6| 7|
DAY ON TEST | 1| 2| 9| 1| 3| 2| 2| 0| 3| 8| 0| 4| 8| 2| 1| 2| 7| 3| 3| 4| 2| 2| 6| 5| 0|
| 2| 9| 8| 0| 2| 5| 9| 6| 0| 4| 5| 8| 1| 9| 2| 9| 8| 0| 0| 7| 9| 9| 5| 2| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
1100 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + + + + + + A +|
Atrophy | 3 |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + A +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + A +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + A +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | 1 |
Eosinophilic Focus | 3 |
Hepatodiaphragmatic Nodule | 4 3 |
Inflammation, Granulomatous | |
Necrosis | |
Thrombosis | 3 |
Vacuolization Cytoplasmic | 3|
Bile Duct, Hyperplasia | 3 |
Hepatocyte, Regeneration | |
|__________________________________________________________________________|
Mesentery | + + + + + + +|
Necrosis | 2 2 2 2 3 3 3|
|__________________________________________________________________________|
Oral Mucosa | + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 85
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 6| 7| 6| 7| 5| 5| 5| 7| 7| 5| 7| 7| 6| 7| 7| 5| 6| 7|
DAY ON TEST | 1| 2| 9| 1| 3| 2| 2| 0| 3| 8| 0| 4| 8| 2| 1| 2| 7| 3| 3| 4| 2| 2| 6| 5| 0|
| 2| 9| 8| 0| 2| 5| 9| 6| 0| 4| 5| 8| 1| 9| 2| 9| 8| 0| 0| 7| 9| 9| 5| 2| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
1100 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 4|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 4|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pulmonary Artery, Thrombosis | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 2 4 |
Atrium, Thrombosis | 3 3 |
Myocardium, Thrombosis | 4 |
Ventricle, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Vacuolization Cytoplasmic | 4 3 1 1 2 4 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 1 1 1 2 3 2 |
Mineralization | |
Necrosis | 4 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hemorrhage | 4 4 4 |
Pars Distalis, Hyperplasia | 3 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 86
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 6| 7| 6| 7| 5| 5| 5| 7| 7| 5| 7| 7| 6| 7| 7| 5| 6| 7|
DAY ON TEST | 1| 2| 9| 1| 3| 2| 2| 0| 3| 8| 0| 4| 8| 2| 1| 2| 7| 3| 3| 4| 2| 2| 6| 5| 0|
| 2| 9| 8| 0| 2| 5| 9| 6| 0| 4| 5| 8| 1| 9| 2| 9| 8| 0| 0| 7| 9| 9| 5| 2| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
1100 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
C-Cell, Hyperplasia | 1 2 3|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Peritoneum | + + + + + + + + + + + +|
Inflammation, Granulomatous | 3 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia | |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 2 |
Inflammation, Suppurative | 4 2 1 2 1 2 4 4 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 |
Hyperplasia | 4 |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation, Chronic Active | |
Germinal Epithelium, Atrophy | 4 3 4 4 4 4 4|
Interstitial Cell, Hyperplasia | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | 2 |
|__________________________________________________________________________|
Lymph Node | + + + + + + |
Hyperplasia, Lymphoid | |
Deep Cervical, Angiectasis | |
Pancreatic, Pigmentation | |
Thoracic, Ectasia | |
__________________________________________|__________________________________________________________________________|
Page 87
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 6| 7| 6| 7| 5| 5| 5| 7| 7| 5| 7| 7| 6| 7| 7| 5| 6| 7|
DAY ON TEST | 1| 2| 9| 1| 3| 2| 2| 0| 3| 8| 0| 4| 8| 2| 1| 2| 7| 3| 3| 4| 2| 2| 6| 5| 0|
| 2| 9| 8| 0| 2| 5| 9| 6| 0| 4| 5| 8| 1| 9| 2| 9| 8| 0| 0| 7| 9| 9| 5| 2| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
1100 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Lymph Node, Bronchial | + M M M M M + + M M M M M M + M M + M M M + M + M|
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + + + + + + + + + + M M + + + + + + + + + + M M|
Infiltration Cellular, Histiocyte | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | |
Fibrosis | 3 3 |
Hemorrhage | 4 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 1 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | 4 |
Hyperkeratosis | 4 |
Hyperplasia | 3 |
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 |
Turbinate, Cartilage, Hyperplasia | 4 |
|__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 88
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 6| 7| 6| 7| 5| 5| 5| 7| 7| 5| 7| 7| 6| 7| 7| 5| 6| 7|
DAY ON TEST | 1| 2| 9| 1| 3| 2| 2| 0| 3| 8| 0| 4| 8| 2| 1| 2| 7| 3| 3| 4| 2| 2| 6| 5| 0|
| 2| 9| 8| 0| 2| 5| 9| 6| 0| 4| 5| 8| 1| 9| 2| 9| 8| 0| 0| 7| 9| 9| 5| 2| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
1100 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 3 4 3 3 |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 4 |
Inflammation, Suppurative | 3 2 |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + A +|
Foreign Body | 1 |
Hemorrhage | 3 3 |
Inflammation, Suppurative | |
Alveolar Epithelium, Hyperplasia | 1 2 4 |
Alveolus, Foreign Body | |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 1 |
Interstitium, Fibrosis | 2 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2|
Inflammation, Suppurative | 2 1 3 2|
Goblet Cell, Hyperplasia | 2 2 |
Olfactory Epithelium, Degeneration, | |
Hyaline | 2|
Respiratory Epithelium, Hyperplasia | |
Turbinate, Hyperplasia, Atypical | 4 |
|__________________________________________________________________________|
Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Inflammation, Chronic | 2 4 1 1 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 89
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
_____________________________________________________________________________________________________________________
| 7| 7| 6| 6| 4| 7| 7| 6| 7| 6| 7| 5| 5| 5| 7| 7| 5| 7| 7| 6| 7| 7| 5| 6| 7|
DAY ON TEST | 1| 2| 9| 1| 3| 2| 2| 0| 3| 8| 0| 4| 8| 2| 1| 2| 7| 3| 3| 4| 2| 2| 6| 5| 0|
| 2| 9| 8| 0| 2| 5| 9| 6| 0| 4| 5| 8| 1| 9| 2| 9| 8| 0| 0| 7| 9| 9| 5| 2| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
1100 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lens, Cataract | 4 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hemorrhage | 4 |
Nephropathy, Chronic | 2 3 4 3 2 3 3 3 3 2 3 1 2 2 3 4 3 2 3 2 3 3 3 3 4|
Cortex, Infarct | 4 |
Cortex, Renal Tubule, Accumulation, | |
Hyaline Droplet | 2 |
Cortex, Renal Tubule, Casts Granular | 1 1 |
Cortex, Renal Tubule, Hyperplasia | 2 2 2 2 2 3 1 2|
Cortex, Renal Tubule, Mineralization | 2 |
Medulla, Casts Granular | |
Papilla, Mineralization | 2 3 3 1 2 1 1 4 3 1 4 2 1 3 1 3 1 1 3 3 2|
Pelvis, Dilatation | 2 |
Pelvis, Transitional Epithelium, | |
Hyperplasia | |
|__________________________________________________________________________|
Ureter | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 4 |
Transitional Epithelium, Hyperplasia | 3 |
__________________________________________|__________________________________________________________________________
Page 90
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 6| 6| 7| 5| 4| 7| 6| 7| 5| 7| 5| 6| 6| 6| 7| 6| 6| 7| 7| 6| |
DAY ON TEST | 2| 8| 7| 6| 2| 7| 8| 2| 9| 6| 2| 3| 2| 2| 2| 6| 8| 4| 9| 2| 9| 9| 3| 1| 4| |
| 9| 4| 3| 7| 9| 5| 4| 9| 3| 5| 9| 6| 9| 2| 9| 3| 3| 5| 1| 9| 1| 1| 0| 7| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
1100 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Atrophy | | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + + + + + A + + + + + A + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + + + + + A + + + + + A + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Clear Cell Focus | X 4| 3 2.5|
Eosinophilic Focus | | 1 3.0|
Hepatodiaphragmatic Nodule | 4 | 3 3.7|
Inflammation, Granulomatous | 2 | 1 2.0|
Necrosis | 4 | 1 4.0|
Thrombosis | | 1 3.0|
Vacuolization Cytoplasmic | 3 | 2 3.0|
Bile Duct, Hyperplasia | 3 | 2 3.0|
Hepatocyte, Regeneration | 4| 1 4.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + | 13 |
Necrosis | 3 3 3 2 3 | 12 2.6|
|__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 91
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 6| 6| 7| 5| 4| 7| 6| 7| 5| 7| 5| 6| 6| 6| 7| 6| 6| 7| 7| 6| |
DAY ON TEST | 2| 8| 7| 6| 2| 7| 8| 2| 9| 6| 2| 3| 2| 2| 2| 6| 8| 4| 9| 2| 9| 9| 3| 1| 4| |
| 9| 4| 3| 7| 9| 5| 4| 9| 3| 5| 9| 6| 9| 2| 9| 3| 3| 5| 1| 9| 1| 1| 0| 7| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
1100 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Acinus, Atrophy | 4 3 | 2 3.5|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | | 1 4.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | 3 | 2 3.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pulmonary Artery, Thrombosis | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 3 2 2 | 9 2.2|
Atrium, Thrombosis | 3 3 3 | 5 3.0|
Myocardium, Thrombosis | | 1 4.0|
Ventricle, Thrombosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Vacuolization Cytoplasmic | 2 2 1 2 | 10 2.2|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 2 4 3 3 2 3 | 15 2.2|
Mineralization | 4 | 1 4.0|
Necrosis | 4 | 2 4.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 1 3.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 92
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 6| 6| 7| 5| 4| 7| 6| 7| 5| 7| 5| 6| 6| 6| 7| 6| 6| 7| 7| 6| |
DAY ON TEST | 2| 8| 7| 6| 2| 7| 8| 2| 9| 6| 2| 3| 2| 2| 2| 6| 8| 4| 9| 2| 9| 9| 3| 1| 4| |
| 9| 4| 3| 7| 9| 5| 4| 9| 3| 5| 9| 6| 9| 2| 9| 3| 3| 5| 1| 9| 1| 1| 0| 7| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
1100 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hemorrhage | | 3 4.0|
Pars Distalis, Hyperplasia | 3 3 3 | 5 2.8|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 1 1 3 2 2 3 1 | 11 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | + + + + + + + + + + + + + + + + + + + +| 32 |
Inflammation, Granulomatous | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 1 |
Hyperplasia | 3 2| 2 2.5|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 3 3.0|
Inflammation, Suppurative | 4 3 2 2 | 12 2.6|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | | 1 4.0|
Hyperplasia | | 1 4.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Artery, Inflammation, Chronic Active | 3 2 | 2 2.5|
Germinal Epithelium, Atrophy | 3 4 4 4 | 11 3.8|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 93
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 6| 6| 7| 5| 4| 7| 6| 7| 5| 7| 5| 6| 6| 6| 7| 6| 6| 7| 7| 6| |
DAY ON TEST | 2| 8| 7| 6| 2| 7| 8| 2| 9| 6| 2| 3| 2| 2| 2| 6| 8| 4| 9| 2| 9| 9| 3| 1| 4| |
| 9| 4| 3| 7| 9| 5| 4| 9| 3| 5| 9| 6| 9| 2| 9| 3| 3| 5| 1| 9| 1| 1| 0| 7| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
1100 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Interstitial Cell, Hyperplasia | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Thrombosis | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + +| 17 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
Deep Cervical, Angiectasis | 3 | 1 3.0|
Pancreatic, Pigmentation | 4 | 1 4.0|
Thoracic, Ectasia | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M M + M M M M M M M M M M M M + M + M M M M + +| 13 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M| |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + + M + + M M + + + + + + + + + + + + + M + + M| 40 |
Infiltration Cellular, Histiocyte | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Spleen | X | 1 |
Fibrosis | 3 3 3 2 | 6 2.8|
Hemorrhage | | 1 4.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 4 | 2 2.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 94
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 6| 6| 7| 5| 4| 7| 6| 7| 5| 7| 5| 6| 6| 6| 7| 6| 6| 7| 7| 6| |
DAY ON TEST | 2| 8| 7| 6| 2| 7| 8| 2| 9| 6| 2| 3| 2| 2| 2| 6| 8| 4| 9| 2| 9| 9| 3| 1| 4| |
| 9| 4| 3| 7| 9| 5| 4| 9| 3| 5| 9| 6| 9| 2| 9| 3| 3| 5| 1| 9| 1| 1| 0| 7| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
1100 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | X 4 | 3 4.0|
Hyperkeratosis | 3 | 2 3.5|
Hyperplasia | | 1 3.0|
Ulcer | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | | 1 3.0|
Turbinate, Cartilage, Hyperplasia | | 1 4.0|
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | 4 3 2 4 | 9 3.3|
Hemorrhage | 3 3 3 | 3 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 4 3 | 3 3.7|
Inflammation, Suppurative | | 2 2.5|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Foreign Body | | 1 1.0|
Hemorrhage | 2 1 | 4 2.3|
Inflammation, Suppurative | 2 4 | 2 3.0|
Alveolar Epithelium, Hyperplasia | 3 1 4 3 | 7 2.6|
Alveolus, Foreign Body | 2 | 1 2.0|
Alveolus, Infiltration Cellular, | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 95
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 6| 6| 7| 5| 4| 7| 6| 7| 5| 7| 5| 6| 6| 6| 7| 6| 6| 7| 7| 6| |
DAY ON TEST | 2| 8| 7| 6| 2| 7| 8| 2| 9| 6| 2| 3| 2| 2| 2| 6| 8| 4| 9| 2| 9| 9| 3| 1| 4| |
| 9| 4| 3| 7| 9| 5| 4| 9| 3| 5| 9| 6| 9| 2| 9| 3| 3| 5| 1| 9| 1| 1| 0| 7| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
1100 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Histiocyte | 1 1 3 | 5 1.4|
Interstitium, Fibrosis | | 1 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 3 | 2 2.5|
Inflammation, Suppurative | 2 | 5 2.0|
Goblet Cell, Hyperplasia | 2 2 | 4 2.0|
Olfactory Epithelium, Degeneration, | | |
Hyaline | 1 2 | 3 1.7|
Respiratory Epithelium, Hyperplasia | 2 | 1 2.0|
Turbinate, Hyperplasia, Atypical | | 1 4.0|
|__________________________________________________________________________|____________|
Pleura | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 1 3.0|
Inflammation, Chronic | 2 | 5 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lens, Cataract | 4 | 2 4.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X| 2 |
Hemorrhage | | 1 4.0|
Nephropathy, Chronic | 3 3 3 2 4 2 3 4 4 2 4 2 2 1 4 2 2 2 3 3 4 3 4 2 2| 50 2.8|
Cortex, Infarct | 4 | 2 4.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 96
NTP Experiment-Test: 96001-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 01/08/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:14:11
__________________________________________________________________________________________________________________________________
| 7| 6| 6| 6| 7| 6| 6| 7| 5| 4| 7| 6| 7| 5| 7| 5| 6| 6| 6| 7| 6| 6| 7| 7| 6| |
DAY ON TEST | 2| 8| 7| 6| 2| 7| 8| 2| 9| 6| 2| 3| 2| 2| 2| 6| 8| 4| 9| 2| 9| 9| 3| 1| 4| |
| 9| 4| 3| 7| 9| 5| 4| 9| 3| 5| 9| 6| 9| 2| 9| 3| 3| 5| 1| 9| 1| 1| 0| 7| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| A |
1100 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
MG/M3 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Cortex, Renal Tubule, Accumulation, | | |
Hyaline Droplet | 4 | 2 3.0|
Cortex, Renal Tubule, Casts Granular | 1 | 3 1.0|
Cortex, Renal Tubule, Hyperplasia | 4 3 3 3 3 1 4 3 2 1 2 3 2 3 2 | 23 2.4|
Cortex, Renal Tubule, Mineralization | | 1 2.0|
Medulla, Casts Granular | 3 1 1 | 3 1.7|
Papilla, Mineralization | 1 1 1 3 3 2 2 2 1 3 1 3 3 3 4 2 4 3| 39 2.2|
Pelvis, Dilatation | | 1 2.0|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | 3 3 2 3 4 | 5 3.0|
|__________________________________________________________________________|____________|
Ureter | + | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 4.0|
Transitional Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
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