TDMS Study 96001-06 Pathology Tables
NTP Experiment-Test: 96001-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 09/25/02
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:00:56
FINAL #1 MICE
Facility: Battelle Northwest
Chemical CAS #: 64742-88-7
Lock Date: 09/25/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 96001-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 09/25/02
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:00:56
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 550 1100 2200
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 6 11 11 10
Natural Death 8 5 12 6
Survivors
Terminal Sacrifice 36 34 27 34
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Small, Duodenum (43) (45) (44) (47)
Infiltration Cellular, Plasma Cell 1 (2%)
Intestine Small, Jejunum (43) (47) (43) (47)
Necrosis 1 (2%)
Intestine Small, Ileum (43) (47) (44) (46)
Inflammation 1 (2%)
Liver (50) (50) (50) (50)
Angiectasis 1 (2%) 1 (2%)
Basophilic Focus 4 (8%) 5 (10%) 8 (16%) 4 (8%)
Clear Cell Focus 4 (8%) 2 (4%) 2 (4%)
Eosinophilic Focus 4 (8%) 9 (18%) 6 (12%) 11 (22%)
Fatty Change 2 (4%) 2 (4%)
Hematopoietic Cell Proliferation 1 (2%)
Infarct 1 (2%)
Inflammation, Granulomatous 1 (2%)
Inflammation, Suppurative 1 (2%)
Mixed Cell Focus 1 (2%) 1 (2%)
Necrosis 3 (6%) 3 (6%) 1 (2%)
Parasite Metazoan 1 (2%)
Tension Lipidosis 2 (4%) 1 (2%) 2 (4%)
Centrilobular, Necrosis 1 (2%) 2 (4%)
Mesentery (4) (15) (21) (11)
Artery, Mineralization 1 (7%)
Fat, Hemorrhage 1 (7%) 1 (5%) 1 (9%)
Fat, Necrosis 3 (75%) 10 (67%) 15 (71%) 9 (82%)
Pancreas (49) (50) (48) (49)
Atrophy 2 (4%)
Atypia Cellular 1 (2%)
Inflammation, Suppurative 1 (2%)
Lipomatosis 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 96001-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 09/25/02
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:00:56
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 550 1100 2200
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Acinus, Hypertrophy 1 (2%)
Duct, Cyst 2 (4%) 1 (2%)
Salivary Glands (50) (49) (49) (50)
Atrophy 1 (2%) 1 (2%)
Stomach, Forestomach (49) (50) (49) (50)
Hyperplasia, Squamous 2 (4%) 2 (4%) 1 (2%) 1 (2%)
Inflammation, Chronic Active 2 (4%) 1 (2%)
Ulcer 1 (2%) 1 (2%)
Stomach, Glandular (47) (49) (47) (47)
Amyloid Deposition 1 (2%)
Mineralization 1 (2%) 1 (2%) 1 (2%)
Necrosis 1 (2%) 1 (2%) 3 (6%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1) (2)
Aorta, Mineralization 1 (100%) 2 (100%)
Heart (50) (50) (50) (50)
Cardiomyopathy 6 (12%) 6 (12%) 6 (12%) 9 (18%)
Mineralization 3 (6%) 4 (8%) 4 (8%)
Thrombosis 2 (4%)
Artery, Inflammation 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (49) (50)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia 4 (8%) 3 (6%) 3 (6%) 6 (12%)
Hypertrophy 2 (4%) 3 (6%) 2 (4%) 3 (6%)
Necrosis 1 (2%)
Vacuolization Cytoplasmic 1 (2%)
Adrenal Medulla (49) (50) (48) (49)
Hyperplasia 2 (4%) 3 (6%) 4 (8%) 2 (4%)
Islets, Pancreatic (49) (50) (48) (48)
Hyperplasia 1 (2%) 1 (2%)
Pituitary Gland (47) (49) (49) (48)
Angiectasis 1 (2%)
Pars Distalis, Hyperplasia 10 (21%) 12 (24%) 16 (33%) 16 (33%)
Pars Intermedia, Hypertrophy 1 (2%)
Thyroid Gland (50) (49) (47) (48)
Inflammation, Chronic 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 96001-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 09/25/02
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:00:56
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 550 1100 2200
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Follicular Cell, Hyperplasia 2 (4%) 1 (2%) 3 (6%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (1)
Inflammation, Acute 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (40) (42) (47) (41)
Fibrosis 1 (2%)
Ovary (49) (50) (48) (49)
Angiectasis 2 (4%)
Cyst 12 (24%) 12 (24%) 9 (19%) 6 (12%)
Uterus (49) (50) (49) (49)
Angiectasis 1 (2%)
Inflammation, Suppurative 1 (2%)
Endometrium, Hyperplasia, Cystic 5 (10%) 3 (6%) 9 (18%) 8 (16%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (49) (48) (50)
Atrophy 1 (2%) 1 (2%)
Cytoplasmic Alteration, Focal 1 (2%)
Hyperplasia 1 (2%)
Lymph Node (5) (7) (9) (10)
Angiectasis 1 (10%)
Iliac, Angiectasis 2 (20%)
Renal, Angiectasis 1 (20%) 2 (29%) 1 (11%) 1 (10%)
Renal, Ectasia 1 (11%)
Lymph Node, Mandibular (42) (32) (40) (40)
Infiltration Cellular, Plasma Cell 1 (3%)
Lymph Node, Mesenteric (47) (49) (47) (50)
Angiectasis 1 (2%) 1 (2%)
Lymph Node, Mediastinal (40) (42) (43) (43)
Infiltration Cellular, Polymorphonuclear 1 (2%)
Spleen (49) (50) (48) (47)
Angiectasis 1 (2%) 1 (2%)
Congestion 1 (2%)
Hematopoietic Cell Proliferation 2 (4%) 8 (16%) 5 (10%) 3 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 96001-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 09/25/02
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:00:56
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 550 1100 2200
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hyperplasia, Lymphoid 1 (2%) 1 (2%) 1 (2%)
Necrosis 1 (2%)
Thymus (43) (45) (47) (46)
Atrophy 2 (4%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (50) (50)
Infiltration Cellular, Mixed Cell 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%) 1 (2%)
Subcutaneous Tissue, Cyst Epithelial
Inclusion 1 (2%)
Subcutaneous Tissue, Edema 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fracture 1 (2%) 1 (2%)
Skeletal Muscle (1) (1) (1) (2)
Hemorrhage 1 (100%)
Inflammation, Suppurative 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Compression 1 (2%)
Necrosis 1 (2%) 1 (2%)
Artery, Inflammation 1 (2%)
Meninges, Infiltration Cellular, Mononuclear
Cell 6 (12%) 2 (4%) 2 (4%) 3 (6%)
Peripheral Nerve (1) (1)
Inflammation, Suppurative 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (50) (50) (50)
Artery, Inflammation 1 (2%)
Lung (50) (50) (50) (50)
Hemorrhage 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 96001-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 09/25/02
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:00:56
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 550 1100 2200
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Alveolar Epithelium, Hyperplasia 1 (2%) 3 (6%) 1 (2%) 3 (6%)
Alveolus, Infiltration Cellular, Histiocyte 1 (2%) 1 (2%)
Nose (49) (50) (50) (49)
Inflammation, Suppurative 1 (2%) 1 (2%) 1 (2%)
Respiratory Epithelium, Degeneration 1 (2%)
Trachea (49) (50) (49) (47)
Artery, Inflammation 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (46) (49) (45) (46)
Cataract 1 (2%) 2 (4%) 2 (4%)
Inflammation, Chronic 1 (2%)
Cornea, Inflammation, Chronic Active 1 (2%) 1 (2%) 2 (4%)
Harderian Gland (49) (49) (49) (49)
Hyperplasia 4 (8%) 3 (6%) 4 (8%) 7 (14%)
Infiltration Cellular 1 (2%)
Inflammation, Granulomatous 1 (2%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (49) (49)
Amyloid Deposition 1 (2%)
Cyst 1 (2%)
Infarct 1 (2%)
Inflammation, Suppurative 1 (2%)
Metaplasia, Osseous 2 (4%) 1 (2%) 2 (4%)
Mineralization 1 (2%) 1 (2%) 2 (4%)
Nephropathy 39 (78%) 32 (64%) 33 (67%) 40 (82%)
Capsule, Fibrosis 1 (2%)
Papilla, Necrosis 1 (2%)
Pelvis, Dilatation 1 (2%)
Renal Tubule, Karyomegaly 1 (2%)
Renal Tubule, Necrosis 1 (2%)
Urinary Bladder (48) (50) (49) (48)
Inflammation, Suppurative 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 96001-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 09/25/02
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:00:56
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 550 1100 2200
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 7 9 16 13
Natural Death 9 9 6 5
Accidently Killed 1
Survivors
Terminal Sacrifice 34 32 27 32
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (39) (36) (41) (43)
Degeneration, Hyaline 1 (3%)
Hyperplasia 1 (3%)
Infiltration Cellular, Mixed Cell 1 (3%)
Inflammation, Chronic Active 1 (3%)
Intestine Large, Cecum (45) (41) (46) (47)
Hemorrhage 1 (2%) 1 (2%)
Intestine Small, Duodenum (46) (41) (46) (47)
Inflammation, Chronic Active 1 (2%)
Intestine Small, Jejunum (46) (41) (46) (47)
Serosa, Inflammation, Granulomatous 1 (2%)
Intestine Small, Ileum (45) (41) (46) (47)
Infiltration Cellular, Plasma Cell 1 (2%)
Inflammation 1 (2%)
Liver (50) (50) (50) (50)
Amyloid Deposition 1 (2%)
Basophilic Focus 9 (18%) 13 (26%) 17 (34%) 11 (22%)
Clear Cell Focus 13 (26%) 11 (22%) 15 (30%) 10 (20%)
Eosinophilic Focus 5 (10%) 7 (14%) 14 (28%) 9 (18%)
Fatty Change 1 (2%) 1 (2%)
Infarct 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%)
Mitotic Alteration 1 (2%)
Mixed Cell Focus 2 (4%) 1 (2%) 1 (2%)
Necrosis 4 (8%) 4 (8%) 2 (4%) 4 (8%)
Tension Lipidosis 2 (4%) 3 (6%) 1 (2%) 2 (4%)
Bile Duct, Cyst 1 (2%)
Centrilobular, Necrosis 1 (2%) 1 (2%)
Mesentery (6) (6) (7) (5)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 96001-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 09/25/02
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:00:56
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 550 1100 2200
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Artery, Inflammation 1 (17%) 1 (14%)
Fat, Hemorrhage 1 (17%)
Fat, Necrosis 4 (67%) 5 (83%) 5 (71%) 5 (100%)
Pancreas (49) (49) (49) (50)
Atrophy 1 (2%) 1 (2%)
Salivary Glands (50) (50) (49) (50)
Atrophy 1 (2%)
Stomach, Forestomach (49) (48) (49) (49)
Hyperplasia, Squamous 5 (10%) 3 (6%) 4 (8%)
Inflammation, Chronic Active 5 (10%) 1 (2%) 2 (4%)
Ulcer 2 (4%) 1 (2%) 2 (4%)
Stomach, Glandular (48) (44) (49) (48)
Degeneration, Hyaline 1 (2%)
Hyperplasia 1 (2%)
Mineralization 2 (4%) 1 (2%)
Necrosis 2 (4%) 1 (2%) 1 (2%)
Vacuolization Cytoplasmic 1 (2%)
Tongue (1)
Mineralization 1 (100%)
Tooth (19) (16) (21) (17)
Malformation 1 (6%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1) (1)
Aorta, Mineralization 1 (100%)
Heart (50) (50) (50) (50)
Amyloid Deposition 1 (2%)
Angiectasis 1 (2%)
Cardiomyopathy 15 (30%) 12 (24%) 21 (42%) 19 (38%)
Infiltration Cellular, Polymorphonuclear 1 (2%)
Mineralization 1 (2%) 2 (4%) 2 (4%) 1 (2%)
Thrombosis 1 (2%) 1 (2%) 1 (2%)
Artery, Inflammation 1 (2%)
Capillary, Endothelium, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (50) (49) (50)
Atrophy 1 (2%)
Hyperplasia 13 (27%) 10 (20%) 7 (14%) 15 (30%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 96001-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 09/25/02
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:00:56
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 550 1100 2200
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hypertrophy 30 (61%) 29 (58%) 20 (41%) 20 (40%)
Adrenal Medulla (48) (49) (49) (50)
Hyperplasia 3 (6%) 4 (8%) 3 (6%) 1 (2%)
Islets, Pancreatic (48) (49) (49) (50)
Hyperplasia 1 (2%) 1 (2%)
Pituitary Gland (49) (49) (48) (46)
Pars Distalis, Hyperplasia 2 (4%) 2 (4%) 2 (4%)
Pars Intermedia, Hyperplasia 1 (2%)
Thyroid Gland (49) (48) (47) (50)
Follicular Cell, Hyperplasia 3 (6%) 2 (4%) 3 (6%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (1) (1) (1)
Inflammation, Suppurative 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (2)
Hyperplasia 1 (50%)
Epididymis (50) (50) (50) (50)
Granuloma Sperm 3 (6%) 3 (6%) 2 (4%)
Infiltration Cellular, Mononuclear Cell 1 (2%)
Penis (3) (1)
Inflammation, Acute 2 (67%) 1 (100%)
Preputial Gland (49) (49) (50) (48)
Ectasia 1 (2%)
Inflammation, Chronic Active 2 (4%) 3 (6%) 2 (4%) 1 (2%)
Prostate (46) (50) (50) (50)
Inflammation, Suppurative 1 (2%) 1 (2%) 1 (2%)
Artery, Inflammation 1 (2%)
Seminal Vesicle (48) (46) (50) (48)
Amyloid Deposition 1 (2%)
Infiltration Cellular, Mononuclear Cell 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 1 (2%)
Testes (50) (50) (50) (50)
Atrophy 2 (4%) 1 (2%) 1 (2%) 2 (4%)
Mineralization 1 (2%)
Germinal Epithelium, Degeneration 1 (2%)
Interstitial Cell, Hyperplasia 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 96001-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 09/25/02
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:00:56
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 550 1100 2200
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (1) (1) (3)
Deep Cervical, Hyperplasia, Lymphoid 1 (33%)
Lumbar, Infiltration Cellular, Plasma Cell 2 (67%)
Lymph Node, Mesenteric (48) (46) (48) (48)
Angiectasis 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Infiltration Cellular, Plasma Cell 1 (2%)
Lymph Node, Mediastinal (39) (40) (36) (43)
Infiltration Cellular, Plasma Cell 1 (2%)
Spleen (49) (49) (49) (50)
Amyloid Deposition 1 (2%)
Angiectasis 1 (2%)
Hematopoietic Cell Proliferation 3 (6%) 3 (6%) 2 (4%)
Thymus (41) (39) (40) (42)
Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (50) (50)
Cyst Epithelial Inclusion 1 (2%)
Infiltration Cellular, Mixed Cell 1 (2%)
Inflammation, Chronic Active 6 (12%) 7 (14%) 11 (22%) 18 (36%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Intervertebral Disc, Necrosis 1 (2%)
Skeletal Muscle (1)
Inflammation, Suppurative 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Inflammation, Granulomatous 1 (2%)
Meninges, Infiltration Cellular, Mononuclear
Cell 1 (2%)
Spinal Cord (1)
Degeneration 1 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 96001-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 09/25/02
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:00:56
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 550 1100 2200
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (49) (50) (50)
Fibrosis 1 (2%)
Hemorrhage 1 (2%) 1 (2%) 2 (4%)
Inflammation, Chronic Active 1 (2%)
Thrombosis 1 (2%) 1 (2%)
Alveolar Epithelium, Hyperplasia 4 (8%) 2 (4%)
Alveolus, Infiltration Cellular, Histiocyte 2 (4%) 1 (2%) 3 (6%) 1 (2%)
Bronchiole, Hyperplasia 2 (4%)
Mediastinum, Thrombosis 1 (2%)
Nose (50) (48) (50) (50)
Inflammation, Suppurative 3 (6%) 2 (4%) 1 (2%) 2 (4%)
Polyp, Inflammatory 1 (2%) 1 (2%)
Olfactory Epithelium, Atrophy 3 (6%) 1 (2%) 2 (4%)
Olfactory Epithelium, Inflammation,
Granulomatous 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (46) (46) (47) (46)
Cornea, Inflammation, Chronic Active 3 (7%) 1 (2%) 1 (2%)
Harderian Gland (50) (50) (50) (49)
Hyperplasia 3 (6%) 4 (8%) 1 (2%) 1 (2%)
Zymbal's Gland (1) (1)
Cyst 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (49) (50)
Amyloid Deposition 1 (2%)
Cyst 3 (6%) 1 (2%) 3 (6%) 1 (2%)
Inflammation, Granulomatous 1 (2%)
Inflammation, Suppurative 1 (2%) 2 (4%) 2 (4%)
Metaplasia, Osseous 3 (6%) 4 (8%) 2 (4%)
Nephropathy 44 (88%) 43 (86%) 42 (86%) 44 (88%)
Capsule, Fibrosis 1 (2%) 1 (2%)
Papilla, Necrosis 1 (2%) 1 (2%)
Pelvis, Dilatation 1 (2%) 2 (4%)
Renal Tubule, Hyperplasia 2 (4%) 1 (2%)
Renal Tubule, Necrosis 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 96001-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC STODDARD SOLVENT (TYPE IIC) Date: 09/25/02
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:00:56
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 550 1100 2200
MG/M3 MG/M3 MG/M3
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Transitional Epithelium, Hyperplasia 1 (2%) 2 (4%)
Urinary Bladder (49) (46) (49) (50)
Infiltration Cellular, Mixed Cell 1 (2%) 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%) 2 (4%)
Transitional Epithelium, Hyperplasia 1 (2%) 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------