https://ntp.niehs.nih.gov/go/4833

TDMS Study 96001-06 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                STODDARD SOLVENT (TYPE IIC)                             DATE: 09/25/02       
EXPERIMENT: 96001 TEST: 06                                                                                     TIME: 11:17:13       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-75410                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C96001       
PATHOLOGIST: GRUMBEIN, SONDR                                                                                   CAS: 64742-88-7      
------------------------------------------------------------------------------------------------------------------------------------
                                                           FINAL #1 MICE                                                            
               REASONS FOR REMOVAL:    ALL                                                                                          
               REMOVAL DATE RANGE:     ALL                                                                                          
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                STODDARD SOLVENT (TYPE IIC)                             DATE: 09/25/02       
EXPERIMENT: 96001 TEST: 06                                                                                     TIME: 11:17:13       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-75410                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C96001       
PATHOLOGIST: GRUMBEIN, SONDR                                                                                   CAS: 64742-88-7      
Mice(B6C3F1)                                                                                                                        
-----------------------------                                                                                                       
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE                                                                   
BASED ON NUMBER OF TISSUES EXAMINED.  IN OTHER TISSUES/ORGANS RATES                                                                 
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.                                                                                      
                                                 ---------------                                                                    
                                                 Adrenal Cortex                                                                     
                                                 Adrenal Medulla                                                                    
                                                 Bone Marrow                                                                        
                                                 Clitoral/Preputial Gland                                                           
                                                 Islets, Pancreatic                                                                 
                                                 Liver                                                                              
                                                 Lung                                                                               
                                                 Nose                                                                               
                                                 Ovary                                                                              
                                                 Pancreas                                                                           
                                                 Pituitary Gland                                                                    
                                                 Spleen                                                                             
                                                 Testes                                                                             
                                                 Thyroid Gland                                                                      
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                STODDARD SOLVENT (TYPE IIC)                             DATE: 09/25/02       
EXPERIMENT: 96001 TEST: 06                                                                                     TIME: 11:17:13       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: NO1-ES-75410                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: C96001       
PATHOLOGIST: GRUMBEIN, SONDR                                                                                   CAS: 64742-88-7      
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS                                                                               
IN THE ANALYSIS OF            STODDARD SOLVENT (TYPE IIC)                                                                           
===============================================================                                                                     
Male Mice                                                                                                                           
------------                                                                                                                        
Organ                                 Morphology                                                                                    
-----                                 ----------                                                                                    
Intestine Small: Ileum                 Carcinoma                                                                                    
Lung                                   Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                               
===============================================================                                                                     
Female Mice                                                                                                                         
------------                                                                                                                        
Organ                                  Morphology                                                                                   
-----                                  ----------                                                                                   
Liver                                  Hepatocellular Adenoma                                                                       
Lung                                   Alveolar/Bronchiolar Carcinoma                                                               
All Organs                             Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated Cell Type      
===============================================================                                                                     
       Date:  09/25/02                           EXPERIMENT: 96001 TEST: 06                                            Page 1       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)        -             STODDARD SOLVENT (TYPE IIC)        
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Cortex                                                                                                                   | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     4/49 (8%)    3/50 (6%)    1/49 (2%)    1/50 (2%)   |1/50 (2%)    1/50 (2%)    0/49 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     4/43.20      3/43.68      1/40.73      1/42.54     |1/45.92      1/43.40      0/42.07      0/44.68      | 
|POLY-3 PERCENT (g) |     9.3%         6.9%         2.5%         2.4%        |2.2%         2.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     4/34 (12%)   2/32 (6%)    1/27 (4%)    1/32 (3%)   |0/36 (0%)    1/34 (3%)    0/27 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     729 (T)      618          729 (T)      729 (T)     |530          730 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.110N     P=0.527N     P=0.253N     P=0.197N    |P=0.248N     P=0.752      P=0.500N     P=0.508N     | 
|POLY 3             |     P=0.096N     P=0.494N     P=0.196N     P=0.183N    |P=0.242N     P=0.748      P=0.517N     P=0.505N     | 
|POLY 1.5           |     P=0.094N     P=0.493N     P=0.192N     P=0.179N    |P=0.240N     P=0.753      P=0.513N     P=0.504N     | 
|POLY 6             |     P=0.098N     P=0.493N     P=0.200N     P=0.187N    |P=0.243N     P=0.742      P=0.525N     P=0.506N     | 
|LOGISTIC REGRESSION|     P=0.100N     P=0.501N     P=0.253N     P=0.197N    |P=0.220N     P=0.732N     P=0.411N     P=0.391N     | 
|COCH-ARM / FISHERS |     P=0.090N     P=0.489N     P=0.181N     P=0.175N    |P=0.236N     P=0.753N     P=0.505N     P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Adrenal Medulla                                                                                                                  | 
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/48 (0%)    0/49 (0%)    0/49 (0%)    0/50 (0%)   |2/49 (4%)    0/50 (0%)    0/48 (0%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |     0/42.82      0/42.68      0/40.73      0/42.54     |2/45.07      0/43.40      0/41.34      1/43.90      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |4.4%         0.0%         0.0%         2.3%         | 
|TERMINAL (d)       |     0/34 (0%)    0/32 (0%)    0/27 (0%)    0/32 (0%)   |1/36 (3%)    0/34 (0%)    0/27 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |594          ---          ---          709          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.469N     P=0.251N     P=0.276N     P=0.509N     | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.458N     P=0.246N     P=0.257N     P=0.509N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.460N     P=0.240N     P=0.252N     P=0.507N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.456N     P=0.253N     P=0.266N     P=0.510N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.460N     P=0.213N     P=0.222N     P=0.488N     | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.463N     P=0.242N     P=0.253N     P=0.500N     | 
|=================================================================================================================================| 
       Date:  09/25/02                           EXPERIMENT: 96001 TEST: 06                                            Page 2       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -             STODDARD SOLVENT (TYPE IIC)         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   6/50 (12%)   5/50 (10%)   4/50 (8%)   |4/50 (8%)    2/50 (4%)    6/50 (12%)   3/50 (6%)    | 
|POLY-3 RATE (b)    |     7/44.05      6/43.68      5/41.65      4/42.54     |4/45.81      2/43.40      6/43.16      3/44.68      | 
|POLY-3 PERCENT (g) |     15.9%        13.7%        12.0%        9.4%        |8.7%         4.6%         13.9%        6.7%         | 
|TERMINAL (d)       |     5/34 (15%)   5/32 (16%)   4/27 (15%)   4/32 (13%)  |2/36 (6%)    2/34 (6%)    4/27 (15%)   3/34 (9%)    | 
|FIRST INCIDENCE    |     651          618          644          729 (T)     |618          730 (T)      673          730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.240N     P=0.534N     P=0.509N     P=0.297N    |P=0.563      P=0.371N     P=0.250      P=0.520N     | 
|POLY 3             |     P=0.219N     P=0.507N     P=0.419N     P=0.280N    |P=0.558N     P=0.362N     P=0.332      P=0.514N     | 
|POLY 1.5           |     P=0.212N     P=0.505N     P=0.409N     P=0.272N    |P=0.560N     P=0.352N     P=0.345      P=0.511N     | 
|POLY 6             |     P=0.229N     P=0.509N     P=0.429N     P=0.291N    |P=0.554N     P=0.376N     P=0.309      P=0.515N     | 
|LOGISTIC REGRESSION|     P=0.220N     P=0.506N     P=0.422N     P=0.281N    |P=0.555N     P=0.350N     P=0.340      P=0.506N     | 
|COCH-ARM / FISHERS |     P=0.200N     P=0.500N     P=0.380N     P=0.262N    |P=0.554N     P=0.339N     P=0.370      P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    4/50 (8%)    3/50 (6%)    3/50 (6%)   |1/50 (2%)    1/50 (2%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.60      4/43.52      3/41.96      3/42.91     |1/45.50      1/43.40      1/43.05      0/44.68      | 
|POLY-3 PERCENT (g) |     0.0%         9.2%         7.2%         7.0%        |2.2%         2.3%         2.3%         0.0%         | 
|TERMINAL (d)       |     0/34 (0%)    2/32 (6%)    2/27 (7%)    2/32 (6%)   |0/36 (0%)    1/34 (3%)    0/27 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     ---          675          527          626         |681          730 (T)      664          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.207      P=0.061      P=0.093      P=0.113     |P=0.319N     P=0.737      P=0.726      P=0.500N     | 
|POLY 3             |     P=0.211      P=0.060      P=0.112      P=0.115     |P=0.315N     P=0.750      P=0.748      P=0.504N     | 
|POLY 1.5           |     P=0.214      P=0.060      P=0.113      P=0.117     |P=0.315N     P=0.754      P=0.752      P=0.503N     | 
|POLY 6             |     P=0.208      P=0.060      P=0.110      P=0.114     |P=0.315N     P=0.745      P=0.740      P=0.503N     | 
|LOGISTIC REGRESSION|     P=0.217      P=0.061      P=0.125      P=0.118     |P=0.312N     P=0.757      P=0.756N     P=0.495N     | 
|COCH-ARM / FISHERS |     P=0.221      P=0.059      P=0.121      P=0.121     |P=0.311N     P=0.753N     P=0.753N     P=0.500N     | 
|=================================================================================================================================| 
       Date:  09/25/02                           EXPERIMENT: 96001 TEST: 06                                            Page 3       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -             STODDARD SOLVENT (TYPE IIC)         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Harderian Gland                                                                                                                  | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   10/50 (20%)  8/50 (16%)   7/50 (14%)  |5/50 (10%)   3/50 (6%)    7/50 (14%)   3/50 (6%)    | 
|POLY-3 RATE (b)    |     7/44.05      10/43.91     8/42.27      7/42.91     |5/46.00      3/43.40      7/43.40      3/44.68      | 
|POLY-3 PERCENT (g) |     15.9%        22.8%        18.9%        16.3%       |10.9%        6.9%         16.1%        6.7%         | 
|TERMINAL (d)       |     5/34 (15%)   7/32 (22%)   6/27 (22%)   6/32 (19%)  |2/36 (6%)    3/34 (9%)    4/27 (15%)   3/34 (9%)    | 
|FIRST INCIDENCE    |     651          618          527          626         |618          730 (T)      664          730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.507N     P=0.270      P=0.356      P=0.566     |P=0.428N     P=0.402N     P=0.255      P=0.377N     | 
|POLY 3             |     P=0.477N     P=0.292      P=0.465      P=0.594     |P=0.408N     P=0.389N     P=0.338      P=0.373N     | 
|POLY 1.5           |     P=0.466N     P=0.293      P=0.472      P=0.601     |P=0.409N     P=0.375N     P=0.353      P=0.368N     | 
|POLY 6             |     P=0.491N     P=0.292      P=0.458      P=0.584     |P=0.405N     P=0.407N     P=0.314      P=0.376N     | 
|LOGISTIC REGRESSION|     P=0.477N     P=0.290      P=0.461      P=0.589     |P=0.405N     P=0.372N     P=0.359      P=0.361N     | 
|COCH-ARM / FISHERS |     P=0.448N     P=0.298      P=0.500      P=0.613N    |P=0.401N     P=0.357N     P=0.380      P=0.357N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small: Ileum                                                                                                           | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.60      0/43.29      0/41.34      2/43.37     |0/45.31      0/43.40      1/43.36      0/44.68      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         4.6%        |0.0%         0.0%         2.3%         0.0%         | 
|TERMINAL (d)       |     0/34 (0%)    0/32 (0%)    0/27 (0%)    0/32 (0%)   |0/36 (0%)    0/34 (0%)    0/27 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          593         |---          ---          557          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.045 *    (e)          (e)          P=0.229     |P=0.689      (e)          P=0.500      (e)          | 
|POLY 3             |     P=0.045 *    (e)          (e)          P=0.236     |P=0.695      (e)          P=0.491      (e)          | 
|POLY 1.5           |     P=0.045 *    (e)          (e)          P=0.236     |P=0.693      (e)          P=0.494      (e)          | 
|POLY 6             |     P=0.045 *    (e)          (e)          P=0.236     |P=0.701      (e)          P=0.485      (e)          | 
|LOGISTIC REGRESSION|     P=0.044 *    (e)          (e)          P=0.264     |P=0.728      (e)          P=0.575      (e)          | 
|COCH-ARM / FISHERS |     P=0.046 *    (e)          (e)          P=0.247     |P=0.694      (e)          P=0.500      (e)          | 
|=================================================================================================================================| 
       Date:  09/25/02                           EXPERIMENT: 96001 TEST: 06                                            Page 4       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -             STODDARD SOLVENT (TYPE IIC)         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small: Jejunum                                                                                                         | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    3/50 (6%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.60      3/43.29      0/41.34      0/42.54     |0/45.31      1/43.40      0/42.80      0/44.68      | 
|POLY-3 PERCENT (g) |     0.0%         6.9%         0.0%         0.0%        |0.0%         2.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/34 (0%)    3/32 (9%)    0/27 (0%)    0/32 (0%)   |0/36 (0%)    1/34 (3%)    0/27 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |---          730 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.331N     P=0.110      (e)          (e)         |P=0.576N     P=0.489      (e)          (e)          | 
|POLY 3             |     P=0.319N     P=0.117      (e)          (e)         |P=0.576N     P=0.491      (e)          (e)          | 
|POLY 1.5           |     P=0.316N     P=0.118      (e)          (e)         |P=0.573N     P=0.495      (e)          (e)          | 
|POLY 6             |     P=0.323N     P=0.117      (e)          (e)         |P=0.580N     P=0.487      (e)          (e)          | 
|LOGISTIC REGRESSION|     (e)          P=0.110      (e)          (e)         |(e)          P=0.489      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.311N     P=0.121      (e)          (e)         |P=0.567N     P=0.500      (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small: Site Unspecified                                                                                                | 
|     Carcinoma                                                                                                                   | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    3/50 (6%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    1/50 (2%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/43.60      3/43.29      0/41.34      2/43.37     |0/45.31      1/43.40      1/43.36      1/44.68      | 
|POLY-3 PERCENT (g) |     0.0%         6.9%         0.0%         4.6%        |0.0%         2.3%         2.3%         2.2%         | 
|TERMINAL (d)       |     0/34 (0%)    3/32 (9%)    0/27 (0%)    0/32 (0%)   |0/36 (0%)    1/34 (3%)    0/27 (0%)    1/34 (3%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          593         |---          730 (T)      557          730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.336      P=0.110      (e)          P=0.229     |P=0.371      P=0.489      P=0.500      P=0.489      | 
|POLY 3             |     P=0.345      P=0.117      (e)          P=0.236     |P=0.381      P=0.491      P=0.491      P=0.497      | 
|POLY 1.5           |     P=0.346      P=0.118      (e)          P=0.236     |P=0.381      P=0.495      P=0.494      P=0.497      | 
|POLY 6             |     P=0.345      P=0.117      (e)          P=0.236     |P=0.384      P=0.487      P=0.485      P=0.498      | 
|LOGISTIC REGRESSION|     P=0.351      P=0.110      (e)          P=0.264     |P=0.388      P=0.489      P=0.575      P=0.489      | 
|COCH-ARM / FISHERS |     P=0.351      P=0.121      (e)          P=0.247     |P=0.384      P=0.500      P=0.500      P=0.500      | 
|=================================================================================================================================| 
       Date:  09/25/02                           EXPERIMENT: 96001 TEST: 06                                            Page 5       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -             STODDARD SOLVENT (TYPE IIC)         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Intestine Small: Site Unspecified                                                                                                | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    4/50 (8%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    1/50 (2%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/43.60      4/43.29      0/41.34      2/43.37     |0/45.31      1/43.40      1/43.36      1/44.68      | 
|POLY-3 PERCENT (g) |     0.0%         9.2%         0.0%         4.6%        |0.0%         2.3%         2.3%         2.2%         | 
|TERMINAL (d)       |     0/34 (0%)    4/32 (13%)   0/27 (0%)    0/32 (0%)   |0/36 (0%)    1/34 (3%)    0/27 (0%)    1/34 (3%)    | 
|FIRST INCIDENCE    |     ---          729 (T)      ---          593         |---          730 (T)      557          730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.424      P=0.055      (e)          P=0.229     |P=0.371      P=0.489      P=0.500      P=0.489      | 
|POLY 3             |     P=0.437      P=0.059      (e)          P=0.236     |P=0.381      P=0.491      P=0.491      P=0.497      | 
|POLY 1.5           |     P=0.438      P=0.059      (e)          P=0.236     |P=0.381      P=0.495      P=0.494      P=0.497      | 
|POLY 6             |     P=0.437      P=0.058      (e)          P=0.236     |P=0.384      P=0.487      P=0.485      P=0.498      | 
|LOGISTIC REGRESSION|     P=0.441      P=0.055      (e)          P=0.264     |P=0.388      P=0.489      P=0.575      P=0.489      | 
|COCH-ARM / FISHERS |     P=0.444      P=0.059      (e)          P=0.247     |P=0.384      P=0.500      P=0.500      P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    3/50 (6%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/43.60      1/43.47      3/41.88      0/42.54     |0/45.31      1/43.40      0/42.80      1/44.70      | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         7.2%         0.0%        |0.0%         2.3%         0.0%         2.2%         | 
|TERMINAL (d)       |     0/34 (0%)    0/32 (0%)    0/27 (0%)    0/32 (0%)   |0/36 (0%)    1/34 (3%)    0/27 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     ---          683          628          ---         |---          730 (T)      ---          725          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.617      P=0.495      P=0.109      (e)         |P=0.395      P=0.489      (e)          P=0.489      | 
|POLY 3             |     P=0.621      P=0.499      P=0.111      (e)         |P=0.400      P=0.491      (e)          P=0.497      | 
|POLY 1.5           |     P=0.627      P=0.499      P=0.113      (e)         |P=0.401      P=0.495      (e)          P=0.497      | 
|POLY 6             |     P=0.614      P=0.500      P=0.111      (e)         |P=0.401      P=0.487      (e)          P=0.498      | 
|LOGISTIC REGRESSION|     P=0.634N     P=0.501      P=0.118      (e)         |P=0.408      P=0.489      (e)          P=0.499      | 
|COCH-ARM / FISHERS |     P=0.634      P=0.500      P=0.121      (e)         |P=0.405      P=0.500      (e)          P=0.500      | 
|=================================================================================================================================| 
       Date:  09/25/02                           EXPERIMENT: 96001 TEST: 06                                            Page 6       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -             STODDARD SOLVENT (TYPE IIC)         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Adenoma                                                                                                      | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     23/50 (46%)  28/50 (56%)  21/50 (42%)  29/50 (58%) |9/50 (18%)   12/50 (24%)  15/50 (30%)  18/50 (36%)  | 
|POLY-3 RATE (b)    |     23/44.70     28/46.14     21/43.49     29/46.13    |9/46.16      12/43.90     15/44.44     18/46.35     | 
|POLY-3 PERCENT (g) |     51.5%        60.7%        48.3%        62.9%       |19.5%        27.3%        33.8%        38.8%        | 
|TERMINAL (d)       |     21/34 (62%)  20/32 (63%)  14/27 (52%)  21/32 (66%) |5/36 (14%)   11/34 (32%)  7/27 (26%)   13/34 (38%)  | 
|FIRST INCIDENCE    |     458          398          509          506         |590          578          600          465          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.147      P=0.151      P=0.395      P=0.103     |P=0.025 *    P=0.260      P=0.053      P=0.037 *    | 
|POLY 3             |     P=0.225      P=0.244      P=0.466N     P=0.180     |P=0.023 *    P=0.264      P=0.095      P=0.032 *    | 
|POLY 1.5           |     P=0.214      P=0.225      P=0.467N     P=0.166     |P=0.022 *    P=0.284      P=0.102      P=0.032 *    | 
|POLY 6             |     P=0.246      P=0.280      P=0.448N     P=0.206     |P=0.024 *    P=0.238      P=0.083      P=0.033 *    | 
|LOGISTIC REGRESSION|     P=0.180      P=0.197      P=0.513N     P=0.131     |P=0.022 *    P=0.272      P=0.104      P=0.035 *    | 
|COCH-ARM / FISHERS |     P=0.215      P=0.212      P=0.420N     P=0.158     |P=0.023 *    P=0.312      P=0.121      P=0.035 *    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     16/50 (32%)  15/50 (30%)  17/50 (34%)  10/50 (20%) |6/50 (12%)   7/50 (14%)   5/50 (10%)   6/50 (12%)   | 
|POLY-3 RATE (b)    |     16/48.66     15/48.38     17/46.19     10/44.77    |6/45.65      7/44.40      5/43.64      6/44.86      | 
|POLY-3 PERCENT (g) |     32.9%        31.0%        36.8%        22.3%       |13.1%        15.8%        11.5%        13.4%        | 
|TERMINAL (d)       |     6/34 (18%)   4/32 (13%)   3/27 (11%)   4/32 (13%)  |4/36 (11%)   4/34 (12%)   2/27 (7%)    4/34 (12%)   | 
|FIRST INCIDENCE    |     458          398          478          563         |668          620          639          705          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.185N     P=0.520N     P=0.377      P=0.186N    |P=0.523N     P=0.452      P=0.606      P=0.596      | 
|POLY 3             |     P=0.181N     P=0.508N     P=0.427      P=0.182N    |P=0.512N     P=0.479      P=0.532N     P=0.609      | 
|POLY 1.5           |     P=0.154N     P=0.504N     P=0.443      P=0.160N    |P=0.511N     P=0.486      P=0.522N     P=0.610      | 
|POLY 6             |     P=0.211N     P=0.513N     P=0.416      P=0.207N    |P=0.511N     P=0.470      P=0.550N     P=0.611      | 
|LOGISTIC REGRESSION|     P=0.071N     P=0.504N     P=0.541N     P=0.083N    |P=0.505N     P=0.487      P=0.520N     P=0.614      | 
|COCH-ARM / FISHERS |     P=0.113N     P=0.500N     P=0.500      P=0.127N    |P=0.500N     P=0.500      P=0.500N     P=0.620N     | 
|=================================================================================================================================| 
       Date:  09/25/02                           EXPERIMENT: 96001 TEST: 06                                            Page 7       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -             STODDARD SOLVENT (TYPE IIC)         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma or Hepatoblastoma                                                                                  | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     16/50 (32%)  15/50 (30%)  17/50 (34%)  11/50 (22%) |6/50 (12%)   7/50 (14%)   5/50 (10%)   6/50 (12%)   | 
|POLY-3 RATE (b)    |     16/48.66     15/48.38     17/46.19     11/44.77    |6/45.65      7/44.40      5/43.64      6/44.86      | 
|POLY-3 PERCENT (g) |     32.9%        31.0%        36.8%        24.6%       |13.1%        15.8%        11.5%        13.4%        | 
|TERMINAL (d)       |     6/34 (18%)   4/32 (13%)   3/27 (11%)   5/32 (16%)  |4/36 (11%)   4/34 (12%)   2/27 (7%)    4/34 (12%)   | 
|FIRST INCIDENCE    |     458          398          478          563         |668          620          639          705          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.246N     P=0.520N     P=0.377      P=0.249N    |P=0.523N     P=0.452      P=0.606      P=0.596      | 
|POLY 3             |     P=0.253N     P=0.508N     P=0.427      P=0.256N    |P=0.512N     P=0.479      P=0.532N     P=0.609      | 
|POLY 1.5           |     P=0.219N     P=0.504N     P=0.443      P=0.227N    |P=0.511N     P=0.486      P=0.522N     P=0.610      | 
|POLY 6             |     P=0.290N     P=0.513N     P=0.416      P=0.287N    |P=0.511N     P=0.470      P=0.550N     P=0.611      | 
|LOGISTIC REGRESSION|     P=0.114N     P=0.504N     P=0.541N     P=0.132N    |P=0.505N     P=0.487      P=0.520N     P=0.614      | 
|COCH-ARM / FISHERS |     P=0.166N     P=0.500N     P=0.500      P=0.184N    |P=0.500N     P=0.500      P=0.500N     P=0.620N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     34/50 (68%)  37/50 (74%)  30/50 (60%)  32/50 (64%) |13/50 (26%)  17/50 (34%)  18/50 (36%)  21/50 (42%)  | 
|POLY-3 RATE (b)    |     34/49.01     37/49.49     30/46.27     32/46.59    |13/46.39     17/44.91     18/44.71     21/46.44     | 
|POLY-3 PERCENT (g) |     69.4%        74.8%        64.8%        68.7%       |28.0%        37.9%        40.3%        45.2%        | 
|TERMINAL (d)       |     23/34 (68%)  21/32 (66%)  15/27 (56%)  22/32 (69%) |8/36 (22%)   13/34 (38%)  9/27 (33%)   15/34 (44%)  | 
|FIRST INCIDENCE    |     458          398          478          506         |590          578          600          465          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.424N     P=0.306      P=0.489      P=0.545N    |P=0.065      P=0.209      P=0.076      P=0.069      | 
|POLY 3             |     P=0.402N     P=0.355      P=0.399N     P=0.560N    |P=0.059      P=0.217      P=0.154      P=0.063      | 
|POLY 1.5           |     P=0.342N     P=0.343      P=0.366N     P=0.505N    |P=0.058      P=0.232      P=0.165      P=0.064      | 
|POLY 6             |     P=0.470N     P=0.374      P=0.426N     P=0.566     |P=0.060      P=0.200      P=0.136      P=0.064      | 
|LOGISTIC REGRESSION|     P=0.245N     P=0.333      P=0.265N     P=0.412N    |P=0.059      P=0.227      P=0.161      P=0.065      | 
|COCH-ARM / FISHERS |     P=0.247N     P=0.330      P=0.266N     P=0.417N    |P=0.063      P=0.257      P=0.194      P=0.069      | 
|=================================================================================================================================| 
       Date:  09/25/02                           EXPERIMENT: 96001 TEST: 06                                            Page 8       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -             STODDARD SOLVENT (TYPE IIC)         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocellular Carcinoma, Hepatocellular Adenoma,                                                                           | 
|     or Hepatoblastoma                                                                                                           | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     34/50 (68%)  37/50 (74%)  30/50 (60%)  32/50 (64%) |13/50 (26%)  17/50 (34%)  18/50 (36%)  21/50 (42%)  | 
|POLY-3 RATE (b)    |     34/49.01     37/49.49     30/46.27     32/46.59    |13/46.39     17/44.91     18/44.71     21/46.44     | 
|POLY-3 PERCENT (g) |     69.4%        74.8%        64.8%        68.7%       |28.0%        37.9%        40.3%        45.2%        | 
|TERMINAL (d)       |     23/34 (68%)  21/32 (66%)  15/27 (56%)  22/32 (69%) |8/36 (22%)   13/34 (38%)  9/27 (33%)   15/34 (44%)  | 
|FIRST INCIDENCE    |     458          398          478          506         |590          578          600          465          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.424N     P=0.306      P=0.489      P=0.545N    |P=0.065      P=0.209      P=0.076      P=0.069      | 
|POLY 3             |     P=0.402N     P=0.355      P=0.399N     P=0.560N    |P=0.059      P=0.217      P=0.154      P=0.063      | 
|POLY 1.5           |     P=0.342N     P=0.343      P=0.366N     P=0.505N    |P=0.058      P=0.232      P=0.165      P=0.064      | 
|POLY 6             |     P=0.470N     P=0.374      P=0.426N     P=0.566     |P=0.060      P=0.200      P=0.136      P=0.064      | 
|LOGISTIC REGRESSION|     P=0.245N     P=0.333      P=0.265N     P=0.412N    |P=0.059      P=0.227      P=0.161      P=0.065      | 
|COCH-ARM / FISHERS |     P=0.247N     P=0.330      P=0.266N     P=0.417N    |P=0.063      P=0.257      P=0.194      P=0.069      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Liver                                                                                                                            | 
|     Hepatocholangiocarcinoma                                                                                                    | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/43.60      0/43.29      0/41.34      0/42.54     |0/45.31      2/43.89      0/42.80      1/44.82      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |0.0%         4.6%         0.0%         2.2%         | 
|TERMINAL (d)       |     0/34 (0%)    0/32 (0%)    0/27 (0%)    0/32 (0%)   |0/36 (0%)    0/34 (0%)    0/27 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          653          ---          694          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.547      P=0.224      (e)          P=0.510      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.532      P=0.230      (e)          P=0.498      | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.533      P=0.233      (e)          P=0.498      | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.533      P=0.227      (e)          P=0.499      | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.543      P=0.251      (e)          P=0.501      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.539      P=0.247      (e)          P=0.500      | 
|=================================================================================================================================| 
       Date:  09/25/02                           EXPERIMENT: 96001 TEST: 06                                            Page 9       
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -             STODDARD SOLVENT (TYPE IIC)         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Adenoma                                                                                                | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     6/50 (12%)   2/49 (4%)    3/50 (6%)    1/50 (2%)   |2/50 (4%)    2/50 (4%)    3/50 (6%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     6/43.60      2/42.55      3/41.44      1/42.54     |2/45.31      2/43.90      3/42.80      1/44.68      | 
|POLY-3 PERCENT (g) |     13.8%        4.7%         7.2%         2.4%        |4.4%         4.6%         7.0%         2.2%         | 
|TERMINAL (d)       |     6/34 (18%)   2/32 (6%)    2/27 (7%)    1/32 (3%)   |2/36 (6%)    1/34 (3%)    3/27 (11%)   1/34 (3%)    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      702          729 (T)     |730 (T)      578          730 (T)      730 (T)      | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.066N     P=0.151N     P=0.353N     P=0.066N    |P=0.434N     P=0.676      P=0.369      P=0.520N     | 
|POLY 3             |     P=0.055N     P=0.140N     P=0.266N     P=0.059N    |P=0.408N     P=0.683      P=0.474      P=0.505N     | 
|POLY 1.5           |     P=0.054N     P=0.141N     P=0.262N     P=0.058N    |P=0.409N     P=0.687      P=0.483      P=0.505N     | 
|POLY 6             |     P=0.056N     P=0.138N     P=0.270N     P=0.060N    |P=0.404N     P=0.678      P=0.457      P=0.503N     | 
|LOGISTIC REGRESSION|     P=0.060N     P=0.151N     P=0.297N     P=0.066N    |P=0.406N     P=0.694N     P=0.369      P=0.520N     | 
|COCH-ARM / FISHERS |     P=0.053N     P=0.141N     P=0.243N     P=0.056N    |P=0.404N     P=0.691N     P=0.500      P=0.500N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma                                                                                              | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     7/50 (14%)   2/49 (4%)    4/50 (8%)    5/50 (10%)  |0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     7/44.15      2/42.76      4/41.52      5/43.21     |0/45.31      0/43.40      0/42.80      2/45.42      | 
|POLY-3 PERCENT (g) |     15.9%        4.7%         9.6%         11.6%       |0.0%         0.0%         0.0%         4.4%         | 
|TERMINAL (d)       |     5/34 (15%)   1/32 (3%)    2/27 (7%)    3/32 (9%)   |0/36 (0%)    0/34 (0%)    0/27 (0%)    1/34 (3%)    | 
|FIRST INCIDENCE    |     628          675          702          506         |---          ---          ---          465          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.505N     P=0.097N     P=0.369N     P=0.420N    |P=0.047 *    (e)          (e)          P=0.231      | 
|POLY 3             |     P=0.475N     P=0.085N     P=0.296N     P=0.394N    |P=0.046 *    (e)          (e)          P=0.238      | 
|POLY 1.5           |     P=0.470N     P=0.086N     P=0.287N     P=0.388N    |P=0.046 *    (e)          (e)          P=0.237      | 
|POLY 6             |     P=0.483N     P=0.085N     P=0.306N     P=0.403N    |P=0.047 *    (e)          (e)          P=0.240      | 
|LOGISTIC REGRESSION|     P=0.479N     P=0.086N     P=0.295N     P=0.390N    |P=0.046 *    (e)          (e)          P=0.284      | 
|COCH-ARM / FISHERS |     P=0.462N     P=0.085N     P=0.262N     P=0.380N    |P=0.046 *    (e)          (e)          P=0.247      | 
|=================================================================================================================================| 
       Date:  09/25/02                           EXPERIMENT: 96001 TEST: 06                                            Page 10      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -             STODDARD SOLVENT (TYPE IIC)         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Lung                                                                                                                             | 
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     13/50 (26%)  4/49 (8%)    6/50 (12%)   6/50 (12%)  |2/50 (4%)    2/50 (4%)    3/50 (6%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     13/44.15     4/42.76      6/41.52      6/43.21     |2/45.31      2/43.90      3/42.80      3/45.42      | 
|POLY-3 PERCENT (g) |     29.5%        9.4%         14.5%        13.9%       |4.4%         4.6%         7.0%         6.6%         | 
|TERMINAL (d)       |     11/34 (32%)  3/32 (9%)    4/27 (15%)   4/32 (13%)  |2/36 (6%)    1/34 (3%)    3/27 (11%)   2/34 (6%)    | 
|FIRST INCIDENCE    |     628          675          702          506         |730 (T)      578          730 (T)      465          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.124N     P=0.023N*    P=0.145N     P=0.084N    |P=0.346      P=0.676      P=0.369      P=0.477      | 
|POLY 3             |     P=0.091N     P=0.016N*    P=0.076N     P=0.063N    |P=0.377      P=0.683      P=0.474      P=0.501      | 
|POLY 1.5           |     P=0.090N     P=0.016N*    P=0.073N     P=0.062N    |P=0.372      P=0.687      P=0.483      P=0.499      | 
|POLY 6             |     P=0.094N     P=0.015N*    P=0.081N     P=0.066N    |P=0.384      P=0.678      P=0.457      P=0.506      | 
|LOGISTIC REGRESSION|     P=0.103N     P=0.017N*    P=0.081N     P=0.070N    |P=0.372      P=0.694N     P=0.369      P=0.515      | 
|COCH-ARM / FISHERS |     P=0.091N     P=0.017N*    P=0.062N     P=0.062N    |P=0.371      P=0.691N     P=0.500      P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Ovary                                                                                                                            | 
|     Cystadenoma                                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |1/49 (2%)    2/50 (4%)    1/48 (2%)    1/49 (2%)    | 
|POLY-3 RATE (b)    |                                                        |1/44.31      2/43.60      1/41.15      1/44.45      | 
|POLY-3 PERCENT (g) |                                                        |2.3%         4.6%         2.4%         2.3%         | 
|TERMINAL (d)       |                                                        |1/35 (3%)    1/34 (3%)    1/27 (4%)    0/34 (0%)    | 
|FIRST INCIDENCE    |                                                        |730 (T)      677          730 (T)      503          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.538N     P=0.479      P=0.703      P=0.755      | 
|POLY 3             |                                                        |P=0.534N     P=0.494      P=0.744      P=0.760N     | 
|POLY 1.5           |                                                        |P=0.535N     P=0.499      P=0.748      P=0.760      | 
|POLY 6             |                                                        |P=0.530N     P=0.489      P=0.737      P=0.757N     | 
|LOGISTIC REGRESSION|                                                        |P=0.529N     P=0.492      P=0.703      P=0.728N     | 
|COCH-ARM / FISHERS |                                                        |P=0.534N     P=0.508      P=0.747      P=0.753N     | 
|=================================================================================================================================| 
       Date:  09/25/02                           EXPERIMENT: 96001 TEST: 06                                            Page 11      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -             STODDARD SOLVENT (TYPE IIC)         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/49 (0%)    0/48 (0%)    0/46 (0%)   |10/47 (21%)  8/49 (16%)   10/49 (20%)  10/48 (21%)  | 
|POLY-3 RATE (b)    |     0/43.28      0/42.55      0/40.08      0/39.42     |10/43.41     8/42.40      10/43.26     10/43.57     | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |23.0%        18.9%        23.1%        23.0%        | 
|TERMINAL (d)       |     0/34 (0%)    0/32 (0%)    0/27 (0%)    0/29 (0%)   |10/35 (29%)  8/33 (24%)   7/27 (26%)   8/34 (24%)   | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |730 (T)      730 (T)      590          554          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.442      P=0.449N     P=0.372      P=0.573      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.490      P=0.417N     P=0.597      P=0.597N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.482      P=0.395N     P=0.591N     P=0.596N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.511      P=0.445N     P=0.578      P=0.587N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.472      P=0.449N     P=0.563      P=0.591      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.488      P=0.360N     P=0.558N     P=0.578N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/49 (0%)    0/49 (0%)    0/48 (0%)    0/46 (0%)   |10/47 (21%)  9/49 (18%)   10/49 (20%)  10/48 (21%)  | 
|POLY-3 RATE (b)    |     0/43.28      0/42.55      0/40.08      0/39.42     |10/43.41     9/42.53      10/43.26     10/43.57     | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         0.0%         0.0%        |23.0%        21.2%        23.1%        23.0%        | 
|TERMINAL (d)       |     0/34 (0%)    0/32 (0%)    0/27 (0%)    0/29 (0%)   |10/35 (29%)  8/33 (24%)   7/27 (26%)   8/34 (24%)   | 
|FIRST INCIDENCE    |     ---          ---          ---          ---         |730 (T)      695          590          554          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.481      P=0.561N     P=0.372      P=0.573      | 
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.525      P=0.520N     P=0.597      P=0.597N     | 
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.517      P=0.497N     P=0.591N     P=0.596N     | 
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.544      P=0.546N     P=0.578      P=0.587N     | 
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.509      P=0.597N     P=0.563      P=0.591      | 
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.524      P=0.459N     P=0.558N     P=0.578N     | 
|=================================================================================================================================| 
       Date:  09/25/02                           EXPERIMENT: 96001 TEST: 06                                            Page 12      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -             STODDARD SOLVENT (TYPE IIC)         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma,                                                                        | 
|     or Fibrous Histiocytoma                                                                                                     | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |1/50 (2%)    0/50 (0%)    5/50 (10%)   2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/44.23      0/43.29      0/41.34      1/42.54     |1/45.39      0/43.40      5/44.25      2/44.70      | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         0.0%         2.4%        |2.2%         0.0%         11.3%        4.5%         | 
|TERMINAL (d)       |     0/34 (0%)    0/32 (0%)    0/27 (0%)    1/32 (3%)   |0/36 (0%)    0/34 (0%)    1/27 (4%)    1/34 (3%)    | 
|FIRST INCIDENCE    |     525          ---          ---          729 (T)     |708          ---          506          725          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.584      P=0.504N     P=0.517N     P=0.751     |P=0.230      P=0.522N     P=0.077      P=0.487      | 
|POLY 3             |     P=0.590      P=0.504N     P=0.513N     P=0.752     |P=0.231      P=0.509N     P=0.095      P=0.495      | 
|POLY 1.5           |     P=0.592      P=0.503N     P=0.510N     P=0.755     |P=0.228      P=0.505N     P=0.097      P=0.495      | 
|POLY 6             |     P=0.588      P=0.506N     P=0.517N     P=0.748     |P=0.237      P=0.514N     P=0.090      P=0.496      | 
|LOGISTIC REGRESSION|     P=0.609      P=0.409N     P=0.396N     P=0.743N    |P=0.237      P=0.507N     P=0.121      P=0.497      | 
|COCH-ARM / FISHERS |     P=0.595      P=0.500N     P=0.500N     P=0.753N    |P=0.232      P=0.500N     P=0.102      P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |1/50 (2%)    0/50 (0%)    5/50 (10%)   2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/44.23      0/43.29      0/41.34      1/42.54     |1/45.39      0/43.40      5/44.25      2/44.70      | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         0.0%         2.4%        |2.2%         0.0%         11.3%        4.5%         | 
|TERMINAL (d)       |     0/34 (0%)    0/32 (0%)    0/27 (0%)    1/32 (3%)   |0/36 (0%)    0/34 (0%)    1/27 (4%)    1/34 (3%)    | 
|FIRST INCIDENCE    |     525          ---          ---          729 (T)     |708          ---          506          725          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.584      P=0.504N     P=0.517N     P=0.751     |P=0.230      P=0.522N     P=0.077      P=0.487      | 
|POLY 3             |     P=0.590      P=0.504N     P=0.513N     P=0.752     |P=0.231      P=0.509N     P=0.095      P=0.495      | 
|POLY 1.5           |     P=0.592      P=0.503N     P=0.510N     P=0.755     |P=0.228      P=0.505N     P=0.097      P=0.495      | 
|POLY 6             |     P=0.588      P=0.506N     P=0.517N     P=0.748     |P=0.237      P=0.514N     P=0.090      P=0.496      | 
|LOGISTIC REGRESSION|     P=0.609      P=0.409N     P=0.396N     P=0.743N    |P=0.237      P=0.507N     P=0.121      P=0.497      | 
|COCH-ARM / FISHERS |     P=0.595      P=0.500N     P=0.500N     P=0.753N    |P=0.232      P=0.500N     P=0.102      P=0.500      | 
|=================================================================================================================================| 
       Date:  09/25/02                           EXPERIMENT: 96001 TEST: 06                                            Page 13      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -             STODDARD SOLVENT (TYPE IIC)         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    1/50 (2%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    | 
|POLY-3 RATE (b)    |     0/43.60      0/43.29      2/41.42      1/42.55     |0/45.31      1/43.56      0/42.80      0/44.68      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.8%         2.4%        |0.0%         2.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/34 (0%)    0/32 (0%)    1/27 (4%)    0/32 (0%)   |0/36 (0%)    0/34 (0%)    0/27 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          709          728         |---          688          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.243      (e)          P=0.199      P=0.494     |P=0.554N     P=0.479      (e)          (e)          | 
|POLY 3             |     P=0.238      (e)          P=0.226      P=0.495     |P=0.576N     P=0.492      (e)          (e)          | 
|POLY 1.5           |     P=0.241      (e)          P=0.228      P=0.497     |P=0.573N     P=0.495      (e)          (e)          | 
|POLY 6             |     P=0.234      (e)          P=0.223      P=0.493     |P=0.579N     P=0.489      (e)          (e)          | 
|LOGISTIC REGRESSION|     P=0.236      (e)          P=0.220      P=0.492     |P=0.567N     P=0.503      (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.246      (e)          P=0.247      P=0.500     |P=0.567N     P=0.500      (e)          (e)          | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Skin                                                                                                                             | 
|     Sarcoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    5/50 (10%)   2/50 (4%)    | 
|POLY-3 RATE (b)    |     1/44.23      0/43.29      0/41.34      0/42.54     |1/45.39      0/43.40      5/44.25      2/44.70      | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         0.0%         0.0%        |2.2%         0.0%         11.3%        4.5%         | 
|TERMINAL (d)       |     0/34 (0%)    0/32 (0%)    0/27 (0%)    0/32 (0%)   |0/36 (0%)    0/34 (0%)    1/27 (4%)    1/34 (3%)    | 
|FIRST INCIDENCE    |     525          ---          ---          ---         |708          ---          506          725          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.311N     P=0.504N     P=0.517N     P=0.504N    |P=0.230      P=0.522N     P=0.077      P=0.487      | 
|POLY 3             |     P=0.304N     P=0.504N     P=0.513N     P=0.508N    |P=0.231      P=0.509N     P=0.095      P=0.495      | 
|POLY 1.5           |     P=0.305N     P=0.503N     P=0.510N     P=0.505N    |P=0.228      P=0.505N     P=0.097      P=0.495      | 
|POLY 6             |     P=0.303N     P=0.506N     P=0.517N     P=0.511N    |P=0.237      P=0.514N     P=0.090      P=0.496      | 
|LOGISTIC REGRESSION|     P=0.266N     P=0.409N     P=0.396N     P=0.412N    |P=0.237      P=0.507N     P=0.121      P=0.497      | 
|COCH-ARM / FISHERS |     P=0.306N     P=0.500N     P=0.500N     P=0.500N    |P=0.232      P=0.500N     P=0.102      P=0.500      | 
|=================================================================================================================================| 
       Date:  09/25/02                           EXPERIMENT: 96001 TEST: 06                                            Page 14      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -             STODDARD SOLVENT (TYPE IIC)         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Squamous Cell Carcinoma or Papilloma Squamous                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/43.60      0/43.29      2/41.46      2/42.83     |0/45.31      0/43.40      1/42.80      1/44.76      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.8%         4.7%        |0.0%         0.0%         2.3%         2.2%         | 
|TERMINAL (d)       |     0/34 (0%)    0/32 (0%)    1/27 (4%)    1/32 (3%)   |0/36 (0%)    0/34 (0%)    1/27 (4%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          698          653         |---          ---          730 (T)      709          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.085      (e)          P=0.215      P=0.233     |P=0.238      (e)          P=0.443      P=0.500      | 
|POLY 3             |     P=0.083      (e)          P=0.226      P=0.233     |P=0.238      (e)          P=0.489      P=0.498      | 
|POLY 1.5           |     P=0.084      (e)          P=0.228      P=0.234     |P=0.236      (e)          P=0.493      P=0.497      | 
|POLY 6             |     P=0.082      (e)          P=0.224      P=0.232     |P=0.242      (e)          P=0.481      P=0.499      | 
|LOGISTIC REGRESSION|     P=0.083      (e)          P=0.223      P=0.236     |P=0.240      (e)          P=0.443      P=0.498      | 
|COCH-ARM / FISHERS |     P=0.086      (e)          P=0.247      P=0.247     |P=0.236      (e)          P=0.500      P=0.500      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Stomach, Forestomach                                                                                                             | 
|     Squamous Cell Papilloma                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |     0/43.60      0/43.29      2/41.46      1/42.54     |0/45.31      0/43.40      1/42.80      1/44.76      | 
|POLY-3 PERCENT (g) |     0.0%         0.0%         4.8%         2.4%        |0.0%         0.0%         2.3%         2.2%         | 
|TERMINAL (d)       |     0/34 (0%)    0/32 (0%)    1/27 (4%)    1/32 (3%)   |0/36 (0%)    0/34 (0%)    1/27 (4%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     ---          ---          698          729 (T)     |---          ---          730 (T)      709          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.240      (e)          P=0.215      P=0.488     |P=0.238      (e)          P=0.443      P=0.500      | 
|POLY 3             |     P=0.238      (e)          P=0.226      P=0.495     |P=0.238      (e)          P=0.489      P=0.498      | 
|POLY 1.5           |     P=0.241      (e)          P=0.228      P=0.497     |P=0.236      (e)          P=0.493      P=0.497      | 
|POLY 6             |     P=0.234      (e)          P=0.224      P=0.493     |P=0.242      (e)          P=0.481      P=0.499      | 
|LOGISTIC REGRESSION|     P=0.237      (e)          P=0.223      P=0.488     |P=0.240      (e)          P=0.443      P=0.498      | 
|COCH-ARM / FISHERS |     P=0.246      (e)          P=0.247      P=0.500     |P=0.236      (e)          P=0.500      P=0.500      | 
|=================================================================================================================================| 
       Date:  09/25/02                           EXPERIMENT: 96001 TEST: 06                                            Page 15      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -             STODDARD SOLVENT (TYPE IIC)         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Testes                                                                                                                           | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    0/50 (0%)    2/50 (4%)   |                                                    | 
|POLY-3 RATE (b)    |     1/43.60      2/43.29      0/41.34      2/42.62     |                                                    | 
|POLY-3 PERCENT (g) |     2.3%         4.6%         0.0%         4.7%        |                                                    | 
|TERMINAL (d)       |     1/34 (3%)    2/32 (6%)    0/27 (0%)    1/32 (3%)   |                                                    | 
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          710         |                                                    | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.450      P=0.479      P=0.546N     P=0.483     |                                                    | 
|POLY 3             |     P=0.460      P=0.497      P=0.511N     P=0.492     |                                                    | 
|POLY 1.5           |     P=0.463      P=0.498      P=0.508N     P=0.495     |                                                    | 
|POLY 6             |     P=0.456      P=0.497      P=0.513N     P=0.489     |                                                    | 
|LOGISTIC REGRESSION|     P=0.454      P=0.479      (e)          P=0.485     |                                                    | 
|COCH-ARM / FISHERS |     P=0.469      P=0.500      P=0.500N     P=0.500     |                                                    | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Adenoma                                                                                                                     | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    0/48 (0%)    0/47 (0%)    0/50 (0%)   |2/50 (4%)    0/49 (0%)    0/47 (0%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |     1/43.38      0/41.78      0/38.85      0/42.54     |2/45.31      0/42.95      0/40.23      0/43.38      | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         0.0%         0.0%        |4.4%         0.0%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/34 (0%)    0/31 (0%)    0/26 (0%)    0/32 (0%)   |2/36 (6%)    0/34 (0%)    0/27 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     681          ---          ---          ---         |730 (T)      ---          ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.315N     P=0.511N     P=0.511N     P=0.516N    |P=0.129N     P=0.251N     P=0.303N     P=0.251N     | 
|POLY 3             |     P=0.303N     P=0.507N     P=0.522N     P=0.504N    |P=0.118N     P=0.249N     P=0.264N     P=0.247N     | 
|POLY 1.5           |     P=0.304N     P=0.506N     P=0.518N     P=0.501N    |P=0.118N     P=0.246N     P=0.260N     P=0.248N     | 
|POLY 6             |     P=0.302N     P=0.509N     P=0.526N     P=0.508N    |P=0.117N     P=0.253N     P=0.272N     P=0.244N     | 
|LOGISTIC REGRESSION|     P=0.304N     P=0.502N     P=0.509N     P=0.493N    |P=0.129N     (e)          (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.304N     P=0.505N     P=0.510N     P=0.495N    |P=0.120N     P=0.253N     P=0.263N     P=0.258N     | 
|=================================================================================================================================| 
       Date:  09/25/02                           EXPERIMENT: 96001 TEST: 06                                            Page 16      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -             STODDARD SOLVENT (TYPE IIC)         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Thyroid Gland: Follicular Cell                                                                                                   | 
|     Carcinoma or Adenoma                                                                                                        | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |                                                        |                                                    | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/49 (2%)    0/48 (0%)    0/47 (0%)    0/50 (0%)   |2/50 (4%)    1/49 (2%)    0/47 (0%)    0/48 (0%)    | 
|POLY-3 RATE (b)    |     1/43.38      0/41.78      0/38.85      0/42.54     |2/45.31      1/42.95      0/40.23      0/43.38      | 
|POLY-3 PERCENT (g) |     2.3%         0.0%         0.0%         0.0%        |4.4%         2.3%         0.0%         0.0%         | 
|TERMINAL (d)       |     0/34 (0%)    0/31 (0%)    0/26 (0%)    0/32 (0%)   |2/36 (6%)    1/34 (3%)    0/27 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     681          ---          ---          ---         |730 (T)      730 (T)      ---          ---          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.315N     P=0.511N     P=0.511N     P=0.516N    |P=0.116N     P=0.520N     P=0.303N     P=0.251N     | 
|POLY 3             |     P=0.303N     P=0.507N     P=0.522N     P=0.504N    |P=0.107N     P=0.519N     P=0.264N     P=0.247N     | 
|POLY 1.5           |     P=0.304N     P=0.506N     P=0.518N     P=0.501N    |P=0.107N     P=0.514N     P=0.260N     P=0.248N     | 
|POLY 6             |     P=0.302N     P=0.509N     P=0.526N     P=0.508N    |P=0.106N     P=0.524N     P=0.272N     P=0.244N     | 
|LOGISTIC REGRESSION|     P=0.304N     P=0.502N     P=0.509N     P=0.493N    |P=0.116N     P=0.520N     (e)          (e)          | 
|COCH-ARM / FISHERS |     P=0.304N     P=0.505N     P=0.510N     P=0.495N    |P=0.106N     P=0.508N     P=0.263N     P=0.258N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Polyp Stromal                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |2/50 (4%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |                                                        |2/45.31      0/43.40      0/42.80      1/45.01      | 
|POLY-3 PERCENT (g) |                                                        |4.4%         0.0%         0.0%         2.2%         | 
|TERMINAL (d)       |                                                        |2/36 (6%)    0/34 (0%)    0/27 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |                                                        |730 (T)      ---          ---          639          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.473N     P=0.251N     P=0.303N     P=0.513N     | 
|POLY 3             |                                                        |P=0.457N     P=0.247N     P=0.250N     P=0.502N     | 
|POLY 1.5           |                                                        |P=0.459N     P=0.243N     P=0.246N     P=0.503N     | 
|POLY 6             |                                                        |P=0.456N     P=0.252N     P=0.258N     P=0.499N     | 
|LOGISTIC REGRESSION|                                                        |P=0.462N     (e)          (e)          P=0.501N     | 
|COCH-ARM / FISHERS |                                                        |P=0.461N     P=0.247N     P=0.247N     P=0.500N     | 
|=================================================================================================================================| 
       Date:  09/25/02                           EXPERIMENT: 96001 TEST: 06                                            Page 17      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -             STODDARD SOLVENT (TYPE IIC)         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|Uterus                                                                                                                           | 
|     Sarcoma Stromal or Polyp Stromal                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |                                                        |3/50 (6%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    | 
|POLY-3 RATE (b)    |                                                        |3/45.31      1/43.88      0/42.80      1/45.01      | 
|POLY-3 PERCENT (g) |                                                        |6.6%         2.3%         0.0%         2.2%         | 
|TERMINAL (d)       |                                                        |3/36 (8%)    0/34 (0%)    0/27 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |                                                        |730 (T)      586          ---          639          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |                                                        |P=0.217N     P=0.326N     P=0.176N     P=0.322N     | 
|POLY 3             |                                                        |P=0.200N     P=0.317N     P=0.129N     P=0.308N     | 
|POLY 1.5           |                                                        |P=0.200N     P=0.313N     P=0.126N     P=0.309N     | 
|POLY 6             |                                                        |P=0.199N     P=0.322N     P=0.136N     P=0.304N     | 
|LOGISTIC REGRESSION|                                                        |P=0.198N     P=0.304N     (e)          P=0.308N     | 
|COCH-ARM / FISHERS |                                                        |P=0.200N     P=0.309N     P=0.121N     P=0.309N     | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangiosarcoma                                                                                                             | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    5/50 (10%)   2/50 (4%)   |1/50 (2%)    4/50 (8%)    0/50 (0%)    3/50 (6%)    | 
|POLY-3 RATE (b)    |     1/44.00      1/43.47      5/41.96      2/42.73     |1/45.77      4/44.06      0/42.80      3/44.70      | 
|POLY-3 PERCENT (g) |     2.3%         2.3%         11.9%        4.7%        |2.2%         9.1%         0.0%         6.7%         | 
|TERMINAL (d)       |     0/34 (0%)    0/32 (0%)    1/27 (4%)    0/32 (0%)   |0/36 (0%)    2/34 (6%)    0/27 (0%)    2/34 (6%)    | 
|FIRST INCIDENCE    |     617          683          628          681         |594          578          ---          725          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.286      P=0.757      P=0.085      P=0.479     |P=0.390      P=0.168      P=0.509N     P=0.291      | 
|POLY 3             |     P=0.285      P=0.758      P=0.090      P=0.490     |P=0.388      P=0.167      P=0.513N     P=0.297      | 
|POLY 1.5           |     P=0.292      P=0.759      P=0.093      P=0.494     |P=0.392      P=0.172      P=0.509N     P=0.299      | 
|POLY 6             |     P=0.277      P=0.758      P=0.088      P=0.485     |P=0.384      P=0.162      P=0.522N     P=0.296      | 
|LOGISTIC REGRESSION|     P=0.299      P=0.755N     P=0.100      P=0.505     |P=0.404      P=0.199      P=0.448N     P=0.306      | 
|COCH-ARM / FISHERS |     P=0.302      P=0.753N     P=0.102      P=0.500     |P=0.404      P=0.181      P=0.500N     P=0.309      | 
|=================================================================================================================================| 
       Date:  09/25/02                           EXPERIMENT: 96001 TEST: 06                                            Page 18      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -             STODDARD SOLVENT (TYPE IIC)         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Hemangiosarcoma or Hemangioma                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    5/50 (10%)   2/50 (4%)   |2/50 (4%)    5/50 (10%)   1/50 (2%)    4/50 (8%)    | 
|POLY-3 RATE (b)    |     2/44.00      1/43.47      5/41.96      2/42.73     |2/46.16      5/44.06      1/42.80      4/45.44      | 
|POLY-3 PERCENT (g) |     4.6%         2.3%         11.9%        4.7%        |4.3%         11.4%        2.3%         8.8%         | 
|TERMINAL (d)       |     1/34 (3%)    0/32 (0%)    1/27 (4%)    0/32 (0%)   |0/36 (0%)    3/34 (9%)    1/27 (4%)    2/34 (6%)    | 
|FIRST INCIDENCE    |     617          683          628          681         |594          578          730 (T)      465          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.432      P=0.510N     P=0.175      P=0.670     |P=0.403      P=0.202      P=0.543N     P=0.325      | 
|POLY 3             |     P=0.439      P=0.504N     P=0.196      P=0.684     |P=0.408      P=0.197      P=0.526N     P=0.330      | 
|POLY 1.5           |     P=0.446      P=0.503N     P=0.201      P=0.687     |P=0.411      P=0.205      P=0.517N     P=0.331      | 
|POLY 6             |     P=0.431      P=0.505N     P=0.194      P=0.679     |P=0.404      P=0.188      P=0.543N     P=0.329      | 
|LOGISTIC REGRESSION|     P=0.451      P=0.497N     P=0.206      P=0.694     |P=0.430      P=0.241      P=0.462N     P=0.383      | 
|COCH-ARM / FISHERS |     P=0.456      P=0.500N     P=0.218      P=0.691N    |P=0.420      P=0.218      P=0.500N     P=0.339      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Histiocytic Sarcoma                                                                                                         | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    3/50 (6%)    0/50 (0%)   |2/50 (4%)    2/50 (4%)    1/50 (2%)    2/50 (4%)    | 
|POLY-3 RATE (b)    |     0/43.60      1/43.68      3/41.68      0/42.54     |2/46.11      2/44.61      1/43.15      2/45.64      | 
|POLY-3 PERCENT (g) |     0.0%         2.3%         7.2%         0.0%        |4.3%         4.5%         2.3%         4.4%         | 
|TERMINAL (d)       |     0/34 (0%)    0/32 (0%)    1/27 (4%)    0/32 (0%)   |1/36 (3%)    0/34 (0%)    0/27 (0%)    0/34 (0%)    | 
|FIRST INCIDENCE    |     ---          618          667          ---         |424          455          634          408          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.617      P=0.505      P=0.108      (e)         |P=0.577N     P=0.683      P=0.538N     P=0.685      | 
|POLY 3             |     P=0.621      P=0.500      P=0.110      (e)         |P=0.581N     P=0.682      P=0.523N     P=0.690      | 
|POLY 1.5           |     P=0.627      P=0.500      P=0.112      (e)         |P=0.581N     P=0.686      P=0.516N     P=0.690      | 
|POLY 6             |     P=0.614      P=0.502      P=0.109      (e)         |P=0.580N     P=0.677      P=0.535N     P=0.693      | 
|LOGISTIC REGRESSION|     P=0.633N     P=0.521      P=0.113      (e)         |P=0.507N     P=0.581N     P=0.413N     P=0.580N     | 
|COCH-ARM / FISHERS |     P=0.634      P=0.500      P=0.121      (e)         |P=0.577N     P=0.691N     P=0.500N     P=0.691N     | 
|=================================================================================================================================| 
       Date:  09/25/02                           EXPERIMENT: 96001 TEST: 06                                            Page 19      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -             STODDARD SOLVENT (TYPE IIC)         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,                                                                        | 
|     NOS, or Undifferentiated Cell Type                                                                                          | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    0/50 (0%)    2/50 (4%)   |5/50 (10%)   9/50 (18%)   11/50 (22%)  8/50 (16%)   | 
|POLY-3 RATE (b)    |     3/43.74      1/43.29      0/41.34      2/42.54     |5/46.01      9/43.64      11/43.84     8/45.01      | 
|POLY-3 PERCENT (g) |     6.9%         2.3%         0.0%         4.7%        |10.9%        20.6%        25.1%        17.8%        | 
|TERMINAL (d)       |     2/34 (6%)    1/32 (3%)    0/27 (0%)    2/32 (6%)   |3/36 (8%)    8/34 (24%)   5/27 (19%)   5/34 (15%)   | 
|FIRST INCIDENCE    |     694          729 (T)      ---          729 (T)     |492          666          652          672          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.469N     P=0.325N     P=0.153N     P=0.527N    |P=0.270      P=0.165      P=0.040 *    P=0.255      | 
|POLY 3             |     P=0.451N     P=0.309N     P=0.129N     P=0.513N    |P=0.276      P=0.163      P=0.066      P=0.261      | 
|POLY 1.5           |     P=0.449N     P=0.308N     P=0.126N     P=0.508N    |P=0.276      P=0.174      P=0.072      P=0.263      | 
|POLY 6             |     P=0.453N     P=0.310N     P=0.131N     P=0.519N    |P=0.284      P=0.150      P=0.059      P=0.264      | 
|LOGISTIC REGRESSION|     P=0.462N     P=0.308N     P=0.132N     P=0.519N    |P=0.288      P=0.174      P=0.079      P=0.270      | 
|COCH-ARM / FISHERS |     P=0.444N     P=0.309N     P=0.121N     P=0.500N    |P=0.292      P=0.194      P=0.086      P=0.277      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Benign Tumors                                                                                                               | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     32/50 (64%)  31/50 (62%)  30/50 (60%)  33/50 (66%) |27/50 (54%)  24/50 (48%)  30/50 (60%)  27/50 (54%)  | 
|POLY-3 RATE (b)    |     32/45.34     31/46.14     30/44.74     33/46.43    |27/47.63     24/44.10     30/45.54     27/47.42     | 
|POLY-3 PERCENT (g) |     70.6%        67.2%        67.1%        71.1%       |56.7%        54.4%        65.9%        56.9%        | 
|TERMINAL (d)       |     27/34 (79%)  23/32 (72%)  19/27 (70%)  23/32 (72%) |20/36 (56%)  22/34 (65%)  18/27 (67%)  18/34 (53%)  | 
|FIRST INCIDENCE    |     458          398          484          506         |530          578          590          465          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.309      P=0.536      P=0.304      P=0.369     |P=0.341      P=0.465N     P=0.074      P=0.492      | 
|POLY 3             |     P=0.484      P=0.448N     P=0.445N     P=0.574     |P=0.462      P=0.497N     P=0.239      P=0.572      | 
|POLY 1.5           |     P=0.457      P=0.475N     P=0.462N     P=0.535     |P=0.436      P=0.430N     P=0.268      P=0.567      | 
|POLY 6             |     P=0.528      P=0.409N     P=0.404N     P=0.571N    |P=0.504      P=0.586      P=0.200      P=0.583N     | 
|LOGISTIC REGRESSION|     P=0.380      P=0.517N     P=0.549N     P=0.441     |P=0.402      P=0.428N     P=0.267      P=0.568      | 
|COCH-ARM / FISHERS |     P=0.441      P=0.500N     P=0.418N     P=0.500     |P=0.424      P=0.345N     P=0.343      P=0.579N     | 
|=================================================================================================================================| 
       Date:  09/25/02                           EXPERIMENT: 96001 TEST: 06                                            Page 20      
                     Statistical Analysis of Primary Tumors in Mice(B6C3F1)       -             STODDARD SOLVENT (TYPE IIC)         
                                         Terminal Sacrifice at 105 weeks                                                            
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant Tumors                                                                                                            | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     23/50 (46%)  23/50 (46%)  25/50 (50%)  23/50 (46%) |19/50 (38%)  26/50 (52%)  23/50 (46%)  23/50 (46%)  | 
|POLY-3 RATE (b)    |     23/48.98     23/48.61     25/46.63     23/46.55    |19/48.29     26/47.35     23/47.02     23/48.31     | 
|POLY-3 PERCENT (g) |     47.0%        47.3%        53.6%        49.4%       |39.3%        54.9%        48.9%        47.6%        | 
|TERMINAL (d)       |     11/34 (32%)  10/32 (31%)  9/27 (33%)   12/32 (38%) |10/36 (28%)  15/34 (44%)  8/27 (30%)   12/34 (35%)  | 
|FIRST INCIDENCE    |     458          398          478          506         |424          455          506          282          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.433      P=0.522      P=0.259      P=0.494     |P=0.343      P=0.109      P=0.125      P=0.269      | 
|POLY 3             |     P=0.406      P=0.566      P=0.328      P=0.486     |P=0.362      P=0.091      P=0.231      P=0.269      | 
|POLY 1.5           |     P=0.444      P=0.572      P=0.347      P=0.519     |P=0.359      P=0.097      P=0.237      P=0.270      | 
|POLY 6             |     P=0.376      P=0.557      P=0.315      P=0.458     |P=0.367      P=0.090      P=0.223      P=0.273      | 
|LOGISTIC REGRESSION|     P=0.514N     P=0.580N     P=0.498      P=0.537N    |P=0.374      P=0.137      P=0.313      P=0.296      | 
|COCH-ARM / FISHERS |     P=0.519      P=0.579N     P=0.421      P=0.579N    |P=0.359      P=0.114      P=0.272      P=0.272      | 
|=================================================================================================================================| 
|                   |                                                        |                                                    | 
|                   |                              Males                     |                       Females                      | 
|Dose               |     CONTROL      550          1100         2200        |CONTROL      550          1100         2200         | 
|                   |                  MG/M3        MG/M3        MG/M3       |             MG/M3        MG/M3        MG/M3        | 
|=================================================================================================================================| 
|                                                                                                                                 | 
|All Organs                                                                                                                       | 
|     Malignant and Benign Tumors                                                                                                 | 
|                                                                                                                                 | 
|                                                                                                                                 | 
|---------------------------------------------------------------------------------------------------------------------------------| 
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            | 
|-----------        |                                                        |                                                    | 
|OVERALL (a)        |     42/50 (84%)  43/50 (86%)  41/50 (82%)  41/50 (82%) |39/50 (78%)  41/50 (82%)  41/50 (82%)  39/50 (78%)  | 
|POLY-3 RATE (b)    |     42/49.49     43/49.70     41/47.07     41/48.00    |39/49.56     41/47.55     41/48.29     39/49.66     | 
|POLY-3 PERCENT (g) |     84.9%        86.5%        87.1%        85.4%       |78.7%        86.2%        84.9%        78.5%        | 
|TERMINAL (d)       |     28/34 (82%)  26/32 (81%)  23/27 (85%)  26/32 (81%) |27/36 (75%)  29/34 (85%)  21/27 (78%)  24/34 (71%)  | 
|FIRST INCIDENCE    |     458          398          478          506         |424          455          506          282          | 
|-------------------|                                                        |                                                    | 
|STATISTICAL TESTS  |                                                        |                                                    | 
|-------------------|                                                        |                                                    | 
|LIFE TABLE         |     P=0.467      P=0.398      P=0.227      P=0.491     |P=0.450      P=0.280      P=0.073      P=0.466      | 
|POLY 3             |     P=0.539      P=0.520      P=0.490      P=0.584     |P=0.444N     P=0.235      P=0.295      P=0.590N     | 
|POLY 1.5           |     P=0.513N     P=0.512      P=0.539      P=0.597N    |P=0.467N     P=0.287      P=0.305      P=0.593N     | 
|POLY 6             |     P=0.498      P=0.531      P=0.455      P=0.556     |P=0.420N     P=0.199      P=0.291      P=0.583N     | 
|LOGISTIC REGRESSION|     P=0.407N     P=0.506      P=0.585N     P=0.509N    |P=0.510N     P=0.369      P=0.370      P=0.587N     | 
|COCH-ARM / FISHERS |     P=0.386N     P=0.500      P=0.500N     P=0.500N    |P=0.500N     P=0.402      P=0.402      P=0.595N     | 
|=================================================================================================================================| 
(a)  Number of tumor-bearing animals /  number of animals examined at site.                                                         
(b)  Number of tumor-bearing animals / Poly-3 number                                                                                
(d)  Observed incidence at terminal kill.                                                                                           
(f)  Beneath the control incidence are the P-values associated with the trend                                                       
test.  Beneath the dosed group incidence are the P-values corresponding to                                                          
pairwise comparisons between the controls and that dosed group.  The life                                                           
table analysis regards tumors in animals dying prior to  terminal kill as                                                           
 being (directly or indirectly) the cause of death.                                                                                 
Logistic regression is an alternative                                                                                               
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage                                                       
and Fishers exact tests compare directly the overall incidence rates                                                                
For all tests a negative trend is indicated by N                                                                                    
(e)  Value of Statistic cannot be computed.                                                                                         
(g)  Poly-3 adjusted lifetime tumor incidence.                                                                                      
(I)  Interim sacrifice                                                                                                              
(T)  Terminal sacrifice                                                                                                             
#   Tumor rates based on number of animals necropsied.                                                                              
*   To the right of any statistical result, indicates significance at (P<=0.05).                                                    
**  To the right of any statistical result, indicates significance at (P<=0.01).