TDMS Study 96007-01 Pathology Tables
NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:29:27
31 WEEK SSAC
Facility: Battelle Columbus Laboratory
Chemical CAS #: 57465-28-8
Lock Date: 01/09/01
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 09/24/98 - 09/25/98
Treatment Groups: Include 001 0 NG/KG
Include 002 10 NG/KG
Include 003 30 NG/KG
Include 004 100 NG/KG
Include 005 175 NG/KG
Include 006 300 NG/KG
Include 007 550 NG/KG
Include 008 1000 NG/KG
Page 1
NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:29:27
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 NG/KG | 0| 0| 0| 0| 0| 1| 2| 2| 2| 2| 3| 4| 5| 5| 6| 8| | L |
| 1| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 9| 5| 6| 1| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Inflammation | 1 1 1 2 1 1 1 | 7 1.1|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
Hypertrophy | 1 1 | 2 1.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 10 |
Hyperplasia | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 10 |
Atrophy | 4 4 4 3 4 4 4 4 | 8 3.9|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 2
NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:29:27
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 NG/KG | 0| 0| 0| 0| 0| 1| 2| 2| 2| 2| 3| 4| 5| 5| 6| 8| | L |
| 1| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 9| 5| 6| 1| 0| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
Inflammation, Suppurative | 1 | 1 1.0|
Metaplasia, Squamous | 2 1 2 1 2 | 5 1.6|
Endometrium, Hyperplasia, Cystic | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Pigmentation | 2 2 1 1 1 2 2 2 2 2 | 10 1.7|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
Atrophy | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Infiltration Cellular, Histiocyte | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 3
NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:29:27
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 NG/KG | 0| 0| 0| 0| 0| 1| 2| 2| 2| 2| 3| 4| 5| 5| 6| 8| | L |
| 1| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 9| 5| 6| 1| 0| | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 4
NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:29:27
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
| 2| 1| 1| 1| 1| 1| 2| 1| 1| 1| 1| 1| 2| 2| 2| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
10 NG/KG | 0| 0| 0| 0| 0| 1| 2| 2| 2| 2| 2| 3| 3| 4| 4| 4| | L |
| 3| 6| 7| 8| 9| 0| 1| 6| 7| 8| 9| 0| 1| 3| 4| 7| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Clear Cell Focus | X | 1 |
Degeneration, Cystic | 1 | 1 1.0|
Inflammation | 1 1 1 1 2 2 1 1 1 1 | 10 1.2|
Mixed Cell Focus | X X | 2 |
Hepatocyte, Hypertrophy | 1 1 1 | 3 1.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
Angiectasis | 2 | 1 2.0|
Hypertrophy | 1 1 1 | 3 1.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + | 3 |
Follicular Cell, Hypertrophy | 1 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 10 |
Atrophy | 4 4 4 4 4 4 4 4 | 8 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
Atrophy | 1 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 5
NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:29:27
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
| 2| 1| 1| 1| 1| 1| 2| 1| 1| 1| 1| 1| 2| 2| 2| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
10 NG/KG | 0| 0| 0| 0| 0| 1| 2| 2| 2| 2| 2| 3| 3| 4| 4| 4| | L |
| 3| 6| 7| 8| 9| 0| 1| 6| 7| 8| 9| 0| 1| 3| 4| 7| | |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Infiltration Cellular, Histiocyte | 1 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:29:27
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
| 2| 2| 1| 1| 1| 1| 1| 2| 2| 1| 1| 1| 1| 2| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
30 NG/KG | 0| 0| 1| 1| 1| 1| 2| 3| 5| 5| 5| 5| 6| 7| 9| | L |
| 2| 3| 6| 7| 8| 9| 0| 4| 2| 7| 8| 9| 0| 3| 6| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 9 |
Inflammation | 1 2 1 1 1 2 1 2 1 | 9 1.3|
Mixed Cell Focus | X X | 2 |
Hepatocyte, Hypertrophy | 2 1 1 1 | 4 1.3|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + | 9 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + | 9 |
Hyperplasia | 1 | 1 1.0|
Hypertrophy | 1 1 | 2 1.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + | 3 |
Follicular Cell, Hypertrophy | 2 1 1 | 3 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + | 9 |
Atrophy | 4 4 4 4 | 4 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + | 9 |
Atrophy | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:29:27
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
| 2| 2| 1| 1| 1| 1| 1| 2| 2| 1| 1| 1| 1| 2| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
30 NG/KG | 0| 0| 1| 1| 1| 1| 2| 3| 5| 5| 5| 5| 6| 7| 9| | L |
| 2| 3| 6| 7| 8| 9| 0| 4| 2| 7| 8| 9| 0| 3| 6| | |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + | 9 |
Infiltration Cellular, Histiocyte | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:29:27
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
| 2| 2| 1| 1| 1| 1| 1| 2| 2| 2| 1| 1| 1| 1| 1| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
100 | 0| 3| 4| 4| 4| 4| 4| 5| 5| 5| 6| 6| 6| 6| 7| 8| | L |
NG/KG | 3| 8| 1| 2| 3| 4| 5| 0| 5| 6| 6| 7| 8| 9| 0| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Basophilic Focus | X | 1 |
Inflammation | 1 2 2 1 1 1 1 1 1 2 | 10 1.3|
Mixed Cell Focus | X X X | 3 |
Necrosis | 1 | 1 1.0|
Pigmentation | 1 1 1 | 3 1.0|
Hepatocyte, Hypertrophy | 1 1 1 1 1 1 | 6 1.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
Hyperplasia | 1 | 1 1.0|
Hypertrophy | 1 1 2 | 3 1.3|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 5 |
Follicular Cell, Hypertrophy | 1 4 2 1 1 | 5 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 10 |
Atrophy | 4 4 4 4 4 4 4 4 4 4 | 10 4.0|
|__________________________________________________________________________|____________|
Uterus | + | 1 |
Endometrium, Hyperplasia, Cystic | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:29:27
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
| 2| 2| 1| 1| 1| 1| 1| 2| 2| 2| 1| 1| 1| 1| 1| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
100 | 0| 3| 4| 4| 4| 4| 4| 5| 5| 5| 6| 6| 6| 6| 7| 8| | L |
NG/KG | 3| 8| 1| 2| 3| 4| 5| 0| 5| 6| 6| 7| 8| 9| 0| 5| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
Atrophy | 1 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Infiltration Cellular, Histiocyte | 1 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:29:27
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
| 1| 1| 1| 1| 1| 2| 2| 1| 1| 1| 1| 1| 2| 2| 2| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
175 | 2| 2| 2| 2| 3| 3| 5| 6| 6| 6| 6| 6| 6| 7| 8| 9| | L |
NG/KG | 6| 7| 8| 9| 0| 8| 5| 1| 2| 3| 4| 5| 9| 0| 9| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Inflammation | 2 2 2 2 2 1 2 1 1 1 | 10 1.6|
Mixed Cell Focus | X | 1 |
Mixed Cell Focus, Multiple | X X | 2 |
Pigmentation | 1 1 1 1 1 | 5 1.0|
Hepatocyte, Hypertrophy | 1 1 2 1 2 1 | 6 1.3|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
Degeneration, Cystic | 1 | 1 1.0|
Hypertrophy | 2 1 | 2 1.5|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + | 6 |
Follicular Cell, Hypertrophy | 3 3 2 2 2 2 | 6 2.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 10 |
Atrophy | 4 4 4 4 4 4 4 4 4 | 9 4.0|
|__________________________________________________________________________|____________|
Uterus | + | 1 |
Inflammation, Suppurative | 1 | 1 1.0|
Metaplasia, Squamous | 1 | 1 1.0|
Endometrium, Hyperplasia, Cystic | 4 | 1 4.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:29:27
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
| 1| 1| 1| 1| 1| 2| 2| 1| 1| 1| 1| 1| 2| 2| 2| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
175 | 2| 2| 2| 2| 3| 3| 5| 6| 6| 6| 6| 6| 6| 7| 8| 9| | L |
NG/KG | 6| 7| 8| 9| 0| 8| 5| 1| 2| 3| 4| 5| 9| 0| 9| 5| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
Atrophy | 1 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Infiltration Cellular, Histiocyte | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:29:27
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
| 1| 1| 1| 1| 1| 2| 2| 1| 1| 1| 1| 1| 2| 2| 2| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
300 | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 3| 5| 7| 9| | L |
NG/KG | 1| 2| 3| 4| 5| 7| 8| 1| 2| 3| 4| 5| 5| 5| 2| 6| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Cholangiofibrosis | 2 | 1 2.0|
Clear Cell Focus | X | 1 |
Inflammation | 2 1 2 1 2 2 2 2 2 1 | 10 1.7|
Mixed Cell Focus | X | 1 |
Mixed Cell Focus, Multiple | X | 1 |
Pigmentation | 1 1 1 1 1 1 1 1 | 8 1.0|
Hepatocyte, Hypertrophy | 1 1 1 1 1 1 1 1 | 8 1.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
Basophilic Focus | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
Hypertrophy | 1 1 2 2 | 4 1.5|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 5 |
Follicular Cell, Hypertrophy | 1 1 1 2 1 | 5 1.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 10 |
Atrophy | 4 4 4 4 4 4 4 4 4 4 | 10 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:29:27
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
| 1| 1| 1| 1| 1| 2| 2| 1| 1| 1| 1| 1| 2| 2| 2| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
300 | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 3| 5| 7| 9| | L |
NG/KG | 1| 2| 3| 4| 5| 7| 8| 1| 2| 3| 4| 5| 5| 5| 2| 6| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Thymus | + + + + + + + + + + | 10 |
Atrophy | 1 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Infiltration Cellular, Histiocyte | 1 | 1 1.0|
Alveolar Epithelium, Metaplasia, | | |
Bronchiolar | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:29:27
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
| 2| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
550 | 1| 1| 2| 2| 2| 2| 3| 4| 4| 4| 4| 4| 6| 7| 8| 9| | L |
NG/KG | 0| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 2| 5| 2| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Cholangiofibrosis | 1 | 1 1.0|
Hepatocyte, Multinucleate | 1 1 | 2 1.0|
Inflammation | 2 2 2 1 2 2 2 1 2 2 | 10 1.8|
Mixed Cell Focus | X X | 2 |
Mixed Cell Focus, Multiple | X | 1 |
Necrosis | 1 | 1 1.0|
Pigmentation | 1 1 1 1 1 1 1 1 | 8 1.0|
Hepatocyte, Hypertrophy | 1 1 1 1 2 1 2 1 2 2 | 10 1.4|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + | 1 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 5 |
Follicular Cell, Hypertrophy | 2 1 1 1 1 | 5 1.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 10 |
Atrophy | 4 4 4 4 4 4 4 | 7 4.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:29:27
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
| 2| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
550 | 1| 1| 2| 2| 2| 2| 3| 4| 4| 4| 4| 4| 6| 7| 8| 9| | L |
NG/KG | 0| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 2| 5| 2| 0| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Spleen | + | 1 |
Hematopoietic Cell Proliferation | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
Atrophy | 1 2 1 1 1 1 1 2 | 8 1.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Infiltration Cellular, Histiocyte | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:29:27
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
| 1| 1| 1| 1| 1| 2| 2| 2| 1| 1| 1| 1| 1| 2| 2| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
1000 | 2| 2| 2| 2| 3| 3| 1| 1| 1| 1| 1| 1| 2| 2| 4| 4| | L |
NG/KG | 6| 7| 8| 9| 0| 9| 1| 5| 6| 7| 8| 9| 0| 2| 2| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Fatty Change, Diffuse | 1 | 1 1.0|
Hepatocyte, Multinucleate | 1 1 1 1 1 1 1 1 | 8 1.0|
Inflammation | 1 2 2 2 2 2 2 2 2 1 | 10 1.8|
Mixed Cell Focus | X X | 2 |
Mixed Cell Focus, Multiple | X X X X | 4 |
Necrosis | 1 2 | 2 1.5|
Pigmentation | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
Toxic Hepatopathy | 2 1 1 2 1 1 1 1 1 1 | 10 1.2|
Hepatocyte, Hypertrophy | 2 2 2 3 2 3 2 2 2 2 | 10 2.2|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
Inflammation, Chronic Active | 1 | 1 1.0|
Acinus, Atrophy | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
Hyperplasia | 2 | 1 2.0|
Hypertrophy | 1 1 2 1 | 4 1.3|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:29:27
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
| 1| 1| 1| 1| 1| 2| 2| 2| 1| 1| 1| 1| 1| 2| 2| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
1000 | 2| 2| 2| 2| 3| 3| 1| 1| 1| 1| 1| 1| 2| 2| 4| 4| | L |
NG/KG | 6| 7| 8| 9| 0| 9| 1| 5| 6| 7| 8| 9| 0| 2| 2| 8| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
Follicular Cell, Hypertrophy | 3 1 3 2 1 1 2 | 7 1.9|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 10 |
Atrophy | 3 4 3 4 | 4 3.5|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
Inflammation, Suppurative | 1 | 1 1.0|
Metaplasia, Squamous | 2 2 2 2 | 4 2.0|
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Pigmentation | 2 1 2 1 2 1 2 1 2 2 | 10 1.6|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
Atrophy | 2 2 2 2 3 3 3 3 1 1 | 10 2.2|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 96007-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:29:27
__________________________________________________________________________________________________________________________________
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | |
DAY ON TEST | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
| 1| 1| 1| 1| 1| 2| 2| 2| 1| 1| 1| 1| 1| 2| 2| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
1000 | 2| 2| 2| 2| 3| 3| 1| 1| 1| 1| 1| 1| 2| 2| 4| 4| | L |
NG/KG | 6| 7| 8| 9| 0| 9| 1| 5| 6| 7| 8| 9| 0| 2| 2| 8| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Infiltration Cellular, Histiocyte | 1 1 1 1 | 4 1.0|
Alveolar Epithelium, Metaplasia, | | |
Bronchiolar | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
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