TDMS Study 96007-01 Pathology Tables
NTP Experiment-Test: 96007-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 10/14/02
Route: GAVAGE TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Time: 15:35:00
31 WEEK SSAC
Facility: Battelle Columbus Laboratory
Chemical CAS #: 57465-28-8
Lock Date: 01/09/01
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 09/24/98 - 09/25/98
Treatment Groups: Include 001 0 NG/KG
Include 002 10 NG/KG
Include 003 30 NG/KG
Include 004 100 NG/KG
Include 005 175 NG/KG
Include 006 300 NG/KG
Include 007 550 NG/KG
Include 008 1000 NG/KG
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 1
NTP Experiment-Test: 96007-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 10/14/02
Route: GAVAGE TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Time: 15:35:00
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG/KG 10 NG/KG 30 NG/KG 100 175 300
NG/KG NG/KG NG/KG
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DISPOSITION SUMMARY
Animals Initially In Study 98 48 98 98 98 98
Scheduled Sacrifice 16 16 15 16 16 16
Early Deaths
Survivors
Animals Examined Microscopically 10 10 9 10 10 10
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ALIMENTARY SYSTEM
Liver (10) (10) (9) (10) (10) (10)
Basophilic Focus 1
Cholangiofibrosis 1 [2.0]
Clear Cell Focus 1 1
Degeneration, Cystic 1 [1.0]
Inflammation 7 [1.1] 10 [1.2] 9 [1.3] 10 [1.3] 10 [1.6] 10 [1.7]
Mixed Cell Focus 2 2 3 1 1
Mixed Cell Focus, Multiple 2 1
Necrosis 1 [1.0]
Pigmentation 3 [1.0] 5 [1.0] 8 [1.0]
Hepatocyte, Hypertrophy 3 [1.0] 4 [1.3] 6 [1.0] 6 [1.3] 8 [1.0]
Pancreas (10) (10) (9) (10) (10) (10)
Basophilic Focus 1
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (9) (10) (10) (10)
Angiectasis 1 [2.0]
Degeneration, Cystic 1 [1.0]
Hyperplasia 1 [1.0] 1 [1.0]
Hypertrophy 2 [1.0] 3 [1.0] 2 [1.0] 3 [1.3] 2 [1.5] 4 [1.5]
Adrenal Medulla (10)
Hyperplasia 1 [1.0]
Thyroid Gland (10) (3) (3) (5) (6) (5)
Follicular Cell, Hypertrophy 3 [1.0] 3 [1.3] 5 [1.8] 6 [2.3] 5 [1.2]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 2
NTP Experiment-Test: 96007-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 10/14/02
Route: GAVAGE TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Time: 15:35:00
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG/KG 10 NG/KG 30 NG/KG 100 175 300
NG/KG NG/KG NG/KG
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (10) (10) (9) (10) (10) (10)
Atrophy 8 [3.9] 8 [4.0] 4 [4.0] 10 [4.0] 9 [4.0] 10 [4.0]
Uterus (10) (1) (1)
Inflammation, Suppurative 1 [1.0] 1 [1.0]
Metaplasia, Squamous 5 [1.6] 1 [1.0]
Endometrium, Hyperplasia, Cystic 1 [1.0] 1 [4.0] 1 [4.0]
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HEMATOPOIETIC SYSTEM
Spleen (10)
Pigmentation 10 [1.7]
Thymus (10) (10) (9) (10) (10) (10)
Atrophy 2 [1.0] 3 [1.0] 1 [1.0] 3 [1.0] 3 [1.0] 3 [1.0]
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INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (9) (10) (10) (10)
Infiltration Cellular, Histiocyte 2 [1.0] 3 [1.0] 2 [1.0] 3 [1.0] 1 [1.0] 1 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 3
NTP Experiment-Test: 96007-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 10/14/02
Route: GAVAGE TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Time: 15:35:00
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG/KG 10 NG/KG 30 NG/KG 100 175 300
NG/KG NG/KG NG/KG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Alveolar Epithelium, Metaplasia, Bronchiolar 1 [1.0]
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SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 4
NTP Experiment-Test: 96007-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 10/14/02
Route: GAVAGE TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Time: 15:35:00
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 550 1000
NG/KG NG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 98 98
Scheduled Sacrifice 16 16
Early Deaths
Survivors
Animals Examined Microscopically 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10)
Cholangiofibrosis 1 [1.0]
Fatty Change, Diffuse 1 [1.0]
Hepatocyte, Multinucleate 2 [1.0] 8 [1.0]
Inflammation 10 [1.8] 10 [1.8]
Mixed Cell Focus 2 2
Mixed Cell Focus, Multiple 1 4
Necrosis 1 [1.0] 2 [1.5]
Pigmentation 8 [1.0] 10 [1.0]
Toxic Hepatopathy 10 [1.2]
Hepatocyte, Hypertrophy 10 [1.4] 10 [2.2]
Pancreas (10) (10)
Inflammation, Chronic Active 1 [1.0]
Acinus, Atrophy 1 [1.0]
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CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10)
Hyperplasia 1 [2.0]
Hypertrophy 4 [1.3]
Thyroid Gland (5) (10)
Follicular Cell, Hypertrophy 5 [1.2] 7 [1.9]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 5
NTP Experiment-Test: 96007-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 10/14/02
Route: GAVAGE TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Time: 15:35:00
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 550 1000
NG/KG NG/KG
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (10) (10)
Atrophy 7 [4.0] 4 [3.5]
Uterus (10)
Inflammation, Suppurative 1 [1.0]
Metaplasia, Squamous 4 [2.0]
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HEMATOPOIETIC SYSTEM
Spleen (1) (10)
Hematopoietic Cell Proliferation 1 [3.0]
Pigmentation 10 [1.6]
Thymus (10) (10)
Atrophy 8 [1.3] 10 [2.2]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10)
Infiltration Cellular, Histiocyte 1 [1.0] 4 [1.0]
Alveolar Epithelium, Metaplasia, Bronchiolar 2 [1.0]
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 6
NTP Experiment-Test: 96007-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 10/14/02
Route: GAVAGE TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Time: 15:35:00
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 550 1000
NG/KG NG/KG
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 7
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