TDMS Study 96007-01 Pathology Tables
NTP Experiment-Test: 96007-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:35:06
53 WEEK SSAC
Facility: Battelle Columbus Laboratory
Chemical CAS #: 57465-28-8
Lock Date: 01/09/01
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 02/25/99 - 02/26/99
Treatment Groups: Include 001 0 NG/KG
Include 002 10 NG/KG
Include 003 30 NG/KG
Include 004 100 NG/KG
Include 005 175 NG/KG
Include 006 300 NG/KG
Include 007 550 NG/KG
Include 008 1000 NG/KG
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 96007-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:35:06
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG/KG 10 NG/KG 30 NG/KG 100 175 300
NG/KG NG/KG NG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 98 48 98 98 98 98
Scheduled Sacrifice 13 15 13 13 13 13
Early Deaths
Survivors
Animals Examined Microscopically 8 8 8 8 8 8
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (8) (8) (8) (8) (8) (8)
Basophilic Focus 2 (25%) 2 (25%) 1 (13%) 2 (25%)
Cholangiofibrosis 1 (13%)
Clear Cell Focus 1 (13%)
Clear Cell Focus, Multiple 1 (13%)
Eosinophilic Focus 1 (13%)
Eosinophilic Focus, Multiple 1 (13%)
Fatty Change, Diffuse 2 (25%)
Hepatocyte, Multinucleate 1 (13%)
Inflammation 8 (100%) 8 (100%) 8 (100%) 8 (100%) 8 (100%) 8 (100%)
Mixed Cell Focus 3 (38%) 3 (38%) 1 (13%) 3 (38%) 2 (25%)
Mixed Cell Focus, Multiple 1 (13%) 2 (25%) 2 (25%) 6 (75%) 3 (38%) 4 (50%)
Necrosis 1 (13%)
Pigmentation 3 (38%) 8 (100%) 7 (88%) 8 (100%)
Toxic Hepatopathy 1 (13%)
Bile Duct, Cyst 1 (13%)
Bile Duct, Hyperplasia 1 (13%)
Hepatocyte, Hypertrophy 3 (38%) 2 (25%) 5 (63%) 6 (75%) 7 (88%)
Pancreas (8) (8) (7) (8) (8) (8)
Inflammation, Chronic Active 1 (13%)
Acinus, Atrophy 1 (13%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (8) (8) (8) (8) (8) (8)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 96007-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:35:06
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG/KG 10 NG/KG 30 NG/KG 100 175 300
NG/KG NG/KG NG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Degeneration, Cystic 1 (13%)
Hyperplasia 1 (13%) 1 (13%) 3 (38%) 1 (13%) 1 (13%)
Hypertrophy 5 (63%) 6 (75%) 3 (38%) 3 (38%) 1 (13%) 4 (50%)
Vacuolization Cytoplasmic 1 (13%) 1 (13%)
Pituitary Gland (8)
Pars Distalis, Hyperplasia 2 (25%)
Thyroid Gland (8) (3) (1) (3) (3) (3)
C-Cell, Hyperplasia 2 (25%)
Follicular Cell, Hypertrophy 1 (13%) 3 (100%) 1 (100%) 3 (100%) 3 (100%) 3 (100%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (8) (8) (8) (8) (8) (8)
Atrophy 8 (100%) 7 (88%) 7 (88%) 8 (100%) 6 (75%) 8 (100%)
Cyst 1 (13%)
Uterus (8) (2) (2)
Inflammation, Suppurative 3 (38%) 2 (100%) 2 (100%)
Metaplasia, Squamous 8 (100%) 1 (50%) 2 (100%)
Endometrium, Hyperplasia, Cystic 2 (100%) 1 (50%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Spleen (8)
Pigmentation 8 (100%)
Thymus (8) (8) (8) (8) (7) (8)
Atrophy 7 (88%) 5 (63%) 6 (75%) 5 (63%) 5 (71%) 7 (88%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (8) (1) (2)
Galactocele 1 (13%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 96007-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:35:06
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG/KG 10 NG/KG 30 NG/KG 100 175 300
NG/KG NG/KG NG/KG
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (8) (8) (8) (8) (8) (8)
Infiltration Cellular, Histiocyte 3 (38%) 4 (50%) 6 (75%) 5 (63%) 4 (50%) 2 (25%)
Inflammation, Chronic Active 1 (13%) 1 (13%)
Alveolar Epithelium, Metaplasia, Bronchiolar 1 (13%) 1 (13%)
Interstitium, Inflammation 1 (13%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 96007-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:35:06
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 550 1000
NG/KG NG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 98 98
Scheduled Sacrifice 13 13
Early Deaths
Survivors
Animals Examined Microscopically 8 8
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (8) (8)
Basophilic Focus 1 (13%) 2 (25%)
Cholangiofibrosis 1 (13%)
Clear Cell Focus 1 (13%)
Eosinophilic Focus, Multiple 1 (13%) 3 (38%)
Fatty Change, Diffuse 1 (13%) 8 (100%)
Fatty Change, Focal 1 (13%)
Hepatocyte, Multinucleate 3 (38%) 8 (100%)
Inflammation 8 (100%) 8 (100%)
Mixed Cell Focus 1 (13%)
Mixed Cell Focus, Multiple 7 (88%) 8 (100%)
Necrosis 1 (13%)
Pigmentation 8 (100%) 8 (100%)
Toxic Hepatopathy 4 (50%) 8 (100%)
Vacuolization Cytoplasmic 1 (13%)
Bile Duct, Hyperplasia 4 (50%) 6 (75%)
Hepatocyte, Hypertrophy 8 (100%) 8 (100%)
Pancreas (8) (8)
Inflammation, Chronic Active 1 (13%)
Acinus, Atrophy 1 (13%)
Acinus, Vacuolization Cytoplasmic 1 (13%) 6 (75%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (8) (8)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 96007-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:35:06
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 550 1000
NG/KG NG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Atrophy 1 (13%)
Degeneration, Cystic 2 (25%)
Hyperplasia 2 (25%) 3 (38%)
Hypertrophy 5 (63%) 5 (63%)
Thyroid Gland (2) (8)
Follicular Cell, Hypertrophy 2 (100%) 5 (63%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (8) (8)
Atrophy 7 (88%) 7 (88%)
Cyst 1 (13%) 1 (13%)
Uterus (8)
Inflammation, Suppurative 1 (13%)
Metaplasia, Squamous 7 (88%)
Cervix, Cyst 1 (13%)
Endometrium, Hyperplasia, Cystic 1 (13%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Spleen (1) (8)
Infarct 1 (100%)
Pigmentation 1 (100%) 8 (100%)
Thymus (8) (7)
Atrophy 8 (100%) 7 (100%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (1) (8)
Hyperplasia 1 (13%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 96007-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:35:06
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 550 1000
NG/KG NG/KG
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (8) (8)
Infiltration Cellular, Histiocyte 3 (38%) 6 (75%)
Alveolar Epithelium, Metaplasia, Bronchiolar 2 (25%) 6 (75%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
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