TDMS Study 96007-01 Pathology Tables
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
FINAL #3/RATS
Facility: Battelle Columbus Laboratory
Chemical CAS #: 57465-28-8
Lock Date: 01/09/01
Cage Range: All
Reasons For Removal: 25022 Accidently Killed 25018 Dosing Accident
25019 Moribund Sacrifice 25020 Natural Death
25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include 001 0 NG/KG
Include 003 30 NG/KG
Include 004 100 NG/KG
Include 005 175 NG/KG
Include 006 300 NG/KG
Include 007 550 NG/KG
Include 008 1000 NG/KG
Include 009 1000 NG/KG/STOP
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 3| 7| 5| 4| 7| 6| 5| 5| 7| 4| 5| 7| 6| 5| 7| 7| 6| 6| 6| 7| 1| 7| 5| 2| 2|
DAY ON TEST | 9| 0| 3| 9| 2| 0| 7| 5| 2| 9| 1| 2| 6| 8| 2| 2| 7| 6| 4| 2| 7| 2| 9| 2| 0|
| 1| 9| 1| 6| 7| 0| 4| 4| 9| 6| 9| 7| 0| 3| 7| 7| 1| 0| 4| 7| 6| 7| 2| 2| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 NG/KG | 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 6| 6|
| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 5| 7| 8| 9| 0| 1| 2| 3| 7| 8| 9| 2| 3|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + M + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | |
|__________________________________________________________________________|
Mesentery | + |
|__________________________________________________________________________|
Oral Mucosa | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + A + + + +|
Acinus, Adenoma | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tooth | + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 2
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 3| 7| 5| 4| 7| 6| 5| 5| 7| 4| 5| 7| 6| 5| 7| 7| 6| 6| 6| 7| 1| 7| 5| 2| 2|
DAY ON TEST | 9| 0| 3| 9| 2| 0| 7| 5| 2| 9| 1| 2| 6| 8| 2| 2| 7| 6| 4| 2| 7| 2| 9| 2| 0|
| 1| 9| 1| 6| 7| 0| 4| 4| 9| 6| 9| 7| 0| 3| 7| 7| 1| 0| 4| 7| 6| 7| 2| 2| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 NG/KG | 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 6| 6|
| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 5| 7| 8| 9| 0| 1| 2| 3| 7| 8| 9| 2| 3|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X X X X X X |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + M + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X |
Pars Distalis, Adenoma, Multiple | X |
Pars Intermedia, Adenoma | X |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + A + + + +|
Bilateral, C-Cell, Adenoma | X X |
C-Cell, Adenoma | X X X X X X X X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + M + + + M + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Oviduct | + |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Stromal | X X |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 3
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 3| 7| 5| 4| 7| 6| 5| 5| 7| 4| 5| 7| 6| 5| 7| 7| 6| 6| 6| 7| 1| 7| 5| 2| 2|
DAY ON TEST | 9| 0| 3| 9| 2| 0| 7| 5| 2| 9| 1| 2| 6| 8| 2| 2| 7| 6| 4| 2| 7| 2| 9| 2| 0|
| 1| 9| 1| 6| 7| 0| 4| 4| 9| 6| 9| 7| 0| 3| 7| 7| 1| 0| 4| 7| 6| 7| 2| 2| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 NG/KG | 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 6| 6|
| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 5| 7| 8| 9| 0| 1| 2| 3| 7| 8| 9| 2| 3|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Vagina | + |
Sarcoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + |
Renal, Nephroblastoma, Metastatic, | |
Kidney | X |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteosarcoma, Metastatic, Bone | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + + + + + + M + + + +|
Carcinoma, Metastatic, Mammary Gland | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | X X |
Carcinoma, Multiple | X |
Fibroadenoma | X X X X X X X X X |
Fibroadenoma, Multiple | X X X X X X X X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroma | |
Keratoacanthoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 4
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 3| 7| 5| 4| 7| 6| 5| 5| 7| 4| 5| 7| 6| 5| 7| 7| 6| 6| 6| 7| 1| 7| 5| 2| 2|
DAY ON TEST | 9| 0| 3| 9| 2| 0| 7| 5| 2| 9| 1| 2| 6| 8| 2| 2| 7| 6| 4| 2| 7| 2| 9| 2| 0|
| 1| 9| 1| 6| 7| 0| 4| 4| 9| 6| 9| 7| 0| 3| 7| 7| 1| 0| 4| 7| 6| 7| 2| 2| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 NG/KG | 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 6| 6|
| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 5| 7| 8| 9| 0| 1| 2| 3| 7| 8| 9| 2| 3|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteosarcoma | |
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma Malignant | X X |
Oligodendroglioma Malignant | X|
|__________________________________________________________________________|
Peripheral Nerve | + +|
|__________________________________________________________________________|
Spinal Cord | + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Carcinoma, Metastatic, Mammary Gland | |
Osteosarcoma, Metastatic, Bone | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteosarcoma, Metastatic, Bone | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 5
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 3| 7| 5| 4| 7| 6| 5| 5| 7| 4| 5| 7| 6| 5| 7| 7| 6| 6| 6| 7| 1| 7| 5| 2| 2|
DAY ON TEST | 9| 0| 3| 9| 2| 0| 7| 5| 2| 9| 1| 2| 6| 8| 2| 2| 7| 6| 4| 2| 7| 2| 9| 2| 0|
| 1| 9| 1| 6| 7| 0| 4| 4| 9| 6| 9| 7| 0| 3| 7| 7| 1| 0| 4| 7| 6| 7| 2| 2| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 NG/KG | 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 6| 6|
| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 5| 7| 8| 9| 0| 1| 2| 3| 7| 8| 9| 2| 3|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
Nephroblastoma | X |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 6
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 6| 7| 3| 3| 7| 2| 3| 6| 6| 7| 6| 7| 6| 3| 5| 6| 6| 4| 7| 7| 7|
DAY ON TEST | 4| 2| 5| 2| 5| 2| 4| 5| 2| 0| 0| 0| 0| 2| 6| 2| 1| 2| 4| 1| 8| 0| 2| 2| 0|
| 6| 9| 0| 7| 2| 7| 3| 4| 9| 1| 9| 3| 7| 9| 0| 9| 8| 1| 1| 1| 8| 5| 7| 7| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 NG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + M + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + M + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + M + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + M + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + M + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X |
|__________________________________________________________________________|
Mesentery | |
|__________________________________________________________________________|
Oral Mucosa | + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + M + + + + + + + + + + + + + + +|
Acinus, Adenoma | X |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + M + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + M + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tooth | + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 7
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 6| 7| 3| 3| 7| 2| 3| 6| 6| 7| 6| 7| 6| 3| 5| 6| 6| 4| 7| 7| 7|
DAY ON TEST | 4| 2| 5| 2| 5| 2| 4| 5| 2| 0| 0| 0| 0| 2| 6| 2| 1| 2| 4| 1| 8| 0| 2| 2| 0|
| 6| 9| 0| 7| 2| 7| 3| 4| 9| 1| 9| 3| 7| 9| 0| 9| 8| 1| 1| 1| 8| 5| 7| 7| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 NG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + M + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + M + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | X X |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + M + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + M + + + + + + M + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X |
Pars Distalis, Adenoma, Multiple | |
Pars Intermedia, Adenoma | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | X |
C-Cell, Adenoma | X X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + M + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Oviduct | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + M + + + + + + + + + + + + + + +|
Polyp Stromal | X X |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 8
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 6| 7| 3| 3| 7| 2| 3| 6| 6| 7| 6| 7| 6| 3| 5| 6| 6| 4| 7| 7| 7|
DAY ON TEST | 4| 2| 5| 2| 5| 2| 4| 5| 2| 0| 0| 0| 0| 2| 6| 2| 1| 2| 4| 1| 8| 0| 2| 2| 0|
| 6| 9| 0| 7| 2| 7| 3| 4| 9| 1| 9| 3| 7| 9| 0| 9| 8| 1| 1| 1| 8| 5| 7| 7| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 NG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Vagina | |
Sarcoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + |
Renal, Nephroblastoma, Metastatic, | |
Kidney | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteosarcoma, Metastatic, Bone | X|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + M + + + + + + + + + + + + + + +|
Hemangiosarcoma | X |
|__________________________________________________________________________|
Spleen | + + + + + + + + + M + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + M + + + + +|
Carcinoma, Metastatic, Mammary Gland | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Adenoma | X X |
Carcinoma | X X |
Carcinoma, Multiple | |
Fibroadenoma | X X X X X X X X X|
Fibroadenoma, Multiple | X X X X X X X X X X X X |
|__________________________________________________________________________|
Skin | + + + + + + + + + M + + + + + + + + + + + + + + +|
Fibroma | X |
Keratoacanthoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 9
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 6| 7| 3| 3| 7| 2| 3| 6| 6| 7| 6| 7| 6| 3| 5| 6| 6| 4| 7| 7| 7|
DAY ON TEST | 4| 2| 5| 2| 5| 2| 4| 5| 2| 0| 0| 0| 0| 2| 6| 2| 1| 2| 4| 1| 8| 0| 2| 2| 0|
| 6| 9| 0| 7| 2| 7| 3| 4| 9| 1| 9| 3| 7| 9| 0| 9| 8| 1| 1| 1| 8| 5| 7| 7| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 NG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteosarcoma | X|
|__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma Malignant | |
Oligodendroglioma Malignant | |
|__________________________________________________________________________|
Peripheral Nerve | |
|__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Carcinoma, Metastatic, Mammary Gland | |
Osteosarcoma, Metastatic, Bone | X|
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteosarcoma, Metastatic, Bone | X|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + M + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 10
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 5| 7| 6| 7| 6| 7| 3| 3| 7| 2| 3| 6| 6| 7| 6| 7| 6| 3| 5| 6| 6| 4| 7| 7| 7|
DAY ON TEST | 4| 2| 5| 2| 5| 2| 4| 5| 2| 0| 0| 0| 0| 2| 6| 2| 1| 2| 4| 1| 8| 0| 2| 2| 0|
| 6| 9| 0| 7| 2| 7| 3| 4| 9| 1| 9| 3| 7| 9| 0| 9| 8| 1| 1| 1| 8| 5| 7| 7| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 NG/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|
| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangiosarcoma | |
Nephroblastoma | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + M + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 11
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
__________________________________________________________________________________________________________________________________
| 5| 4| 1| | |
DAY ON TEST | 4| 0| 2| | |
| 7| 0| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| | A |
0 NG/KG | 9| 9| 9| | L |
| 5| 6| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + | 52 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 52 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 52 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 52 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 52 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 52 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 52 |
|__________________________________________________________________________|____________|
Liver | + + + | 53 |
Hepatocellular Adenoma | | 1 |
|__________________________________________________________________________|____________|
Mesentery | | 1 |
|__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + | 51 |
Acinus, Adenoma | | 1 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + | 51 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 52 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 51 |
|__________________________________________________________________________|____________|
Tooth | | 12 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 12
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
__________________________________________________________________________________________________________________________________
| 5| 4| 1| | |
DAY ON TEST | 4| 0| 2| | |
| 7| 0| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| | A |
0 NG/KG | 9| 9| 9| | L |
| 5| 6| 8| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + | 53 |
|__________________________________________________________________________|____________|
Heart | + + + | 52 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 52 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 52 |
Pheochromocytoma Benign | | 8 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 52 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + | 47 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + | 51 |
Pars Distalis, Adenoma | | 14 |
Pars Distalis, Adenoma, Multiple | | 1 |
Pars Intermedia, Adenoma | | 1 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + | 52 |
Bilateral, C-Cell, Adenoma | | 3 |
C-Cell, Adenoma | | 12 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + M + | 50 |
|__________________________________________________________________________|____________|
Ovary | + + + | 52 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 13
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
__________________________________________________________________________________________________________________________________
| 5| 4| 1| | |
DAY ON TEST | 4| 0| 2| | |
| 7| 0| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| | A |
0 NG/KG | 9| 9| 9| | L |
| 5| 6| 8| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Oviduct | | 1 |
|__________________________________________________________________________|____________|
Uterus | + + + | 52 |
Polyp Stromal | | 4 |
|__________________________________________________________________________|____________|
Vagina | | 1 |
Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + | 53 |
|__________________________________________________________________________|____________|
Lymph Node | | 2 |
Renal, Nephroblastoma, Metastatic, | | |
Kidney | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + | 52 |
Osteosarcoma, Metastatic, Bone | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 52 |
Hemangiosarcoma | | 1 |
|__________________________________________________________________________|____________|
Spleen | + + + | 52 |
|__________________________________________________________________________|____________|
Thymus | + + + | 50 |
Carcinoma, Metastatic, Mammary Gland | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + | 52 |
Adenoma | | 2 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 14
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
__________________________________________________________________________________________________________________________________
| 5| 4| 1| | |
DAY ON TEST | 4| 0| 2| | |
| 7| 0| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| | A |
0 NG/KG | 9| 9| 9| | L |
| 5| 6| 8| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
| | |
Carcinoma | X | 5 |
Carcinoma, Multiple | | 1 |
Fibroadenoma | | 18 |
Fibroadenoma, Multiple | X | 21 |
|__________________________________________________________________________|____________|
Skin | + + + | 52 |
Fibroma | | 1 |
Keratoacanthoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + | 53 |
Osteosarcoma | | 1 |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + | 53 |
Astrocytoma Malignant | | 2 |
Oligodendroglioma Malignant | | 1 |
|__________________________________________________________________________|____________|
Peripheral Nerve | | 2 |
|__________________________________________________________________________|____________|
Spinal Cord | | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + | 53 |
Alveolar/Bronchiolar Adenoma | | 1 |
Carcinoma, Metastatic, Mammary Gland | X | 1 |
Osteosarcoma, Metastatic, Bone | | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 15
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
__________________________________________________________________________________________________________________________________
| 5| 4| 1| | |
DAY ON TEST | 4| 0| 2| | |
| 7| 0| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| | A |
0 NG/KG | 9| 9| 9| | L |
| 5| 6| 8| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Nose | + + + | 53 |
Osteosarcoma, Metastatic, Bone | | 1 |
|__________________________________________________________________________|____________|
Trachea | + + + | 53 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + | 51 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + | 53 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + | 53 |
Hemangiosarcoma | | 1 |
Nephroblastoma | | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + | 51 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + | 53 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 16
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 0| 7| 3| 6| 7| 5| 4| 7| 5| 7| 6| 7| 7| 7| 6| 2| 5| 5|
DAY ON TEST | 7| 5| 2| 2| 2| 2| 2| 8| 2| 2| 5| 2| 7| 9| 2| 7| 2| 3| 2| 2| 2| 5| 5| 1| 2|
| 1| 2| 9| 8| 7| 9| 7| 2| 9| 8| 2| 7| 2| 8| 8| 4| 8| 0| 7| 8| 7| 2| 3| 6| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
30 NG/KG | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4|
| 1| 4| 5| 6| 7| 8| 0| 2| 1| 2| 3| 4| 5| 6| 8| 0| 1| 3| 5| 6| 7| 8| 9| 0| 1|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Carcinoma, Metastatic, Uterus| |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Carcinoma, Metastatic, Uterus| |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Carcinoma, Metastatic, Uterus| |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X |
Leukemia Granulocytic | |
Lymphoma Malignant | X X |
|__________________________________________________________________________|
Oral Mucosa | |
Gingival, Squamous Cell Carcinoma | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + M + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Carcinoma, Metastatic, Uterus| |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Carcinoma, Metastatic, Uterus| |
__________________________________________|__________________________________________________________________________|
Page 17
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 0| 7| 3| 6| 7| 5| 4| 7| 5| 7| 6| 7| 7| 7| 6| 2| 5| 5|
DAY ON TEST | 7| 5| 2| 2| 2| 2| 2| 8| 2| 2| 5| 2| 7| 9| 2| 7| 2| 3| 2| 2| 2| 5| 5| 1| 2|
| 1| 2| 9| 8| 7| 9| 7| 2| 9| 8| 2| 7| 2| 8| 8| 4| 8| 0| 7| 8| 7| 2| 3| 6| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
30 NG/KG | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4|
| 1| 4| 5| 6| 7| 8| 0| 2| 1| 2| 3| 4| 5| 6| 8| 0| 1| 3| 5| 6| 7| 8| 9| 0| 1|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
|__________________________________________________________________________|
Tooth | + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X |
Schwannoma Malignant | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | |
Leukemia Granulocytic | |
Lymphoma Malignant | X |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
Pheochromocytoma Benign | X |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + M + + + + + + + + + + + +|
Adenoma | X X |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + + + + + + + + +|
Adenoma | X |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | |
Sarcoma, Metastatic, Brain | |
Pars Distalis, Adenoma | X X X X X X X|
Pars Intermedia, Adenoma | X X |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 18
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 0| 7| 3| 6| 7| 5| 4| 7| 5| 7| 6| 7| 7| 7| 6| 2| 5| 5|
DAY ON TEST | 7| 5| 2| 2| 2| 2| 2| 8| 2| 2| 5| 2| 7| 9| 2| 7| 2| 3| 2| 2| 2| 5| 5| 1| 2|
| 1| 2| 9| 8| 7| 9| 7| 2| 9| 8| 2| 7| 2| 8| 8| 4| 8| 0| 7| 8| 7| 2| 3| 6| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
30 NG/KG | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4|
| 1| 4| 5| 6| 7| 8| 0| 2| 1| 2| 3| 4| 5| 6| 8| 0| 1| 3| 5| 6| 7| 8| 9| 0| 1|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | X |
C-Cell, Adenoma | X X X X X X|
C-Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Oviduct | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
Polyp Stromal | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | |
Lymphoma Malignant | X X |
|__________________________________________________________________________|
Lymph Node | + + + + + +|
Lumbar, Lymphoma Malignant | X |
Mediastinal, Lymphoma Malignant | X X |
Pancreatic, Lymphoma Malignant | X |
Renal, Lymphoma Malignant | X |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 19
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 0| 7| 3| 6| 7| 5| 4| 7| 5| 7| 6| 7| 7| 7| 6| 2| 5| 5|
DAY ON TEST | 7| 5| 2| 2| 2| 2| 2| 8| 2| 2| 5| 2| 7| 9| 2| 7| 2| 3| 2| 2| 2| 5| 5| 1| 2|
| 1| 2| 9| 8| 7| 9| 7| 2| 9| 8| 2| 7| 2| 8| 8| 4| 8| 0| 7| 8| 7| 2| 3| 6| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
30 NG/KG | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4|
| 1| 4| 5| 6| 7| 8| 0| 2| 1| 2| 3| 4| 5| 6| 8| 0| 1| 3| 5| 6| 7| 8| 9| 0| 1|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | |
Lymphoma Malignant | X X |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | |
Lymphoma Malignant | X X |
Capsule, Carcinoma, Metastatic, | |
Uterus | |
|__________________________________________________________________________|
Thymus | + + M + + + M + + + + + + + + + M + + + + + + + +|
Lymphoma Malignant | X X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X X |
Carcinoma, Multiple | |
Fibroadenoma | X X X X X X X X|
Fibroadenoma, Multiple | X X X X X X X |
Lymphoma Malignant | X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + |
Rhabdomyosarcoma | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | |
__________________________________________|__________________________________________________________________________|
Page 20
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 6| 6| 7| 7| 7| 7| 7| 0| 7| 3| 6| 7| 5| 4| 7| 5| 7| 6| 7| 7| 7| 6| 2| 5| 5|
DAY ON TEST | 7| 5| 2| 2| 2| 2| 2| 8| 2| 2| 5| 2| 7| 9| 2| 7| 2| 3| 2| 2| 2| 5| 5| 1| 2|
| 1| 2| 9| 8| 7| 9| 7| 2| 9| 8| 2| 7| 2| 8| 8| 4| 8| 0| 7| 8| 7| 2| 3| 6| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
30 NG/KG | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4|
| 1| 4| 5| 6| 7| 8| 0| 2| 1| 2| 3| 4| 5| 6| 8| 0| 1| 3| 5| 6| 7| 8| 9| 0| 1|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Meninges, Sarcoma | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma | X |
Leukemia Granulocytic | |
Lymphoma Malignant | X X |
Squamous Cell Carcinoma, Metastatic, | |
Oral Mucosa | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X |
Nephroblastoma | X |
Stromal Nephroma | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Carcinoma, Metastatic, Uterus| |
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | |
Lymphoma Malignant | X X |
__________________________________________|__________________________________________________________________________|
Page 21
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 7| 7| 2| 7| 4| 7| 4| 3| 3| 3| 3| 2| 7| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 3| 0| 4| 5| 5| 5| 5| 0| 2| 8| 0| 4| 3| 2| 2| 2| 2| 2| 2| 2| 2|
| 8| 0| 3| 7| 4| 0| 8| 0| 6| 6| 6| 2| 7| 1| 7| 6| 0| 9| 0| 8| 7| 9| 8| 7| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
30 NG/KG | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 8| 8| 8| 9| 9| 9|
| 2| 3| 4| 5| 7| 9| 0| 1| 3| 4| 5| 6| 1| 2| 4| 5| 7| 8| 9| 6| 8| 9| 0| 1| 2|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Carcinoma, Metastatic, Uterus| X |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + M + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + M + + + + + + + + + + + + + + + + + + + +|
Serosa, Carcinoma, Metastatic, Uterus| X |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + M + + + + + + + + + + + + + + + + + + + +|
Serosa, Carcinoma, Metastatic, Uterus| X |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Adenoma | X |
Leukemia Granulocytic | X |
Lymphoma Malignant | |
|__________________________________________________________________________|
Oral Mucosa | + |
Gingival, Squamous Cell Carcinoma | X |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Carcinoma, Metastatic, Uterus| X |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Serosa, Carcinoma, Metastatic, Uterus| X |
__________________________________________|__________________________________________________________________________|
Page 22
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 7| 7| 2| 7| 4| 7| 4| 3| 3| 3| 3| 2| 7| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 3| 0| 4| 5| 5| 5| 5| 0| 2| 8| 0| 4| 3| 2| 2| 2| 2| 2| 2| 2| 2|
| 8| 0| 3| 7| 4| 0| 8| 0| 6| 6| 6| 2| 7| 1| 7| 6| 0| 9| 0| 8| 7| 9| 8| 7| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
30 NG/KG | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 8| 8| 8| 9| 9| 9|
| 2| 3| 4| 5| 7| 9| 0| 1| 3| 4| 5| 6| 1| 2| 4| 5| 7| 8| 9| 6| 8| 9| 0| 1| 2|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
|__________________________________________________________________________|
Tooth | + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
Schwannoma Malignant | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X |
Leukemia Granulocytic | X |
Lymphoma Malignant | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
Pheochromocytoma Benign | X X |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + + + M + + M + + M + + +|
Adenoma | |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | X |
Sarcoma, Metastatic, Brain | X |
Pars Distalis, Adenoma | X X X X X X X X |
Pars Intermedia, Adenoma | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 23
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 7| 7| 2| 7| 4| 7| 4| 3| 3| 3| 3| 2| 7| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 3| 0| 4| 5| 5| 5| 5| 0| 2| 8| 0| 4| 3| 2| 2| 2| 2| 2| 2| 2| 2|
| 8| 0| 3| 7| 4| 0| 8| 0| 6| 6| 6| 2| 7| 1| 7| 6| 0| 9| 0| 8| 7| 9| 8| 7| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
30 NG/KG | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 8| 8| 8| 9| 9| 9|
| 2| 3| 4| 5| 7| 9| 0| 1| 3| 4| 5| 6| 1| 2| 4| 5| 7| 8| 9| 6| 8| 9| 0| 1| 2|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | X X|
C-Cell, Adenoma | X X X X |
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + M + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Oviduct | + |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X X |
Polyp Stromal | X X X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | X |
Lymphoma Malignant | |
|__________________________________________________________________________|
Lymph Node | |
Lumbar, Lymphoma Malignant | |
Mediastinal, Lymphoma Malignant | |
Pancreatic, Lymphoma Malignant | |
Renal, Lymphoma Malignant | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 24
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 7| 7| 2| 7| 4| 7| 4| 3| 3| 3| 3| 2| 7| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 3| 0| 4| 5| 5| 5| 5| 0| 2| 8| 0| 4| 3| 2| 2| 2| 2| 2| 2| 2| 2|
| 8| 0| 3| 7| 4| 0| 8| 0| 6| 6| 6| 2| 7| 1| 7| 6| 0| 9| 0| 8| 7| 9| 8| 7| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
30 NG/KG | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 8| 8| 8| 9| 9| 9|
| 2| 3| 4| 5| 7| 9| 0| 1| 3| 4| 5| 6| 1| 2| 4| 5| 7| 8| 9| 6| 8| 9| 0| 1| 2|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | X |
Lymphoma Malignant | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | X |
Lymphoma Malignant | |
Capsule, Carcinoma, Metastatic, | |
Uterus | X |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X X X |
Carcinoma, Multiple | |
Fibroadenoma | X X X X X X X X X |
Fibroadenoma, Multiple | X X X X X|
Lymphoma Malignant | |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibroma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | |
Rhabdomyosarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | X |
__________________________________________|__________________________________________________________________________|
Page 25
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 7| 7| 2| 7| 4| 7| 4| 3| 3| 3| 3| 2| 7| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 2| 2| 2| 3| 0| 4| 5| 5| 5| 5| 0| 2| 8| 0| 4| 3| 2| 2| 2| 2| 2| 2| 2| 2|
| 8| 0| 3| 7| 4| 0| 8| 0| 6| 6| 6| 2| 7| 1| 7| 6| 0| 9| 0| 8| 7| 9| 8| 7| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
30 NG/KG | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 8| 8| 8| 9| 9| 9|
| 2| 3| 4| 5| 7| 9| 0| 1| 3| 4| 5| 6| 1| 2| 4| 5| 7| 8| 9| 6| 8| 9| 0| 1| 2|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
Meninges, Sarcoma | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Carcinoma | |
Leukemia Granulocytic | X |
Lymphoma Malignant | |
Squamous Cell Carcinoma, Metastatic, | |
Oral Mucosa | X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + M M + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
Nephroblastoma | X |
Stromal Nephroma | X |
|__________________________________________________________________________|
Urinary Bladder | + + + + M + + + + + + + + + + + + + + + + + + + +|
Serosa, Carcinoma, Metastatic, Uterus| X |
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Granulocytic | X |
Lymphoma Malignant | |
__________________________________________|__________________________________________________________________________|
Page 26
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| | |
DAY ON TEST | 2| 8| 2| 2| 2| | |
| 2| 0| 9| 7| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| | A |
30 NG/KG | 9| 9| 9| 9| 9| | L |
| 3| 4| 5| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + | 55 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 55 |
Serosa, Carcinoma, Metastatic, Uterus| | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + | 55 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 54 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 55 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 54 |
Serosa, Carcinoma, Metastatic, Uterus| | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 54 |
Serosa, Carcinoma, Metastatic, Uterus| | 1 |
|__________________________________________________________________________|____________|
Liver | + + + + + | 55 |
Hepatocellular Adenoma | | 2 |
Leukemia Granulocytic | | 1 |
Lymphoma Malignant | | 2 |
|__________________________________________________________________________|____________|
Oral Mucosa | | 1 |
Gingival, Squamous Cell Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + | 55 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 54 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 55 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 27
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| | |
DAY ON TEST | 2| 8| 2| 2| 2| | |
| 2| 0| 9| 7| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| | A |
30 NG/KG | 9| 9| 9| 9| 9| | L |
| 3| 4| 5| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Serosa, Carcinoma, Metastatic, Uterus| | 1 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 53 |
Serosa, Carcinoma, Metastatic, Uterus| | 1 |
|__________________________________________________________________________|____________|
Tooth | | 12 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + | 55 |
Lymphoma Malignant | | 2 |
|__________________________________________________________________________|____________|
Heart | + + + + + | 54 |
Lymphoma Malignant | | 2 |
Schwannoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + | 55 |
Adenoma | | 1 |
Carcinoma | | 1 |
Leukemia Granulocytic | | 1 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + | 55 |
Lymphoma Malignant | | 1 |
Pheochromocytoma Benign | | 3 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 54 |
Adenoma | | 2 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + | 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 28
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| | |
DAY ON TEST | 2| 8| 2| 2| 2| | |
| 2| 0| 9| 7| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| | A |
30 NG/KG | 9| 9| 9| 9| 9| | L |
| 3| 4| 5| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
| | |
Adenoma | | 1 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + | 54 |
Leukemia Granulocytic | | 1 |
Sarcoma, Metastatic, Brain | | 1 |
Pars Distalis, Adenoma | X X X | 18 |
Pars Intermedia, Adenoma | | 2 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 55 |
Bilateral, C-Cell, Adenoma | X | 4 |
C-Cell, Adenoma | X | 11 |
C-Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + | 55 |
|__________________________________________________________________________|____________|
Ovary | + + + + + | 54 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Oviduct | | 1 |
|__________________________________________________________________________|____________|
Uterus | + + + + + | 55 |
Carcinoma | | 3 |
Polyp Stromal | | 5 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 55 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 29
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| | |
DAY ON TEST | 2| 8| 2| 2| 2| | |
| 2| 0| 9| 7| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| | A |
30 NG/KG | 9| 9| 9| 9| 9| | L |
| 3| 4| 5| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Leukemia Granulocytic | | 1 |
Lymphoma Malignant | | 2 |
|__________________________________________________________________________|____________|
Lymph Node | | 6 |
Lumbar, Lymphoma Malignant | | 1 |
Mediastinal, Lymphoma Malignant | | 2 |
Pancreatic, Lymphoma Malignant | | 1 |
Renal, Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + | 53 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 54 |
Leukemia Granulocytic | | 1 |
Lymphoma Malignant | | 2 |
|__________________________________________________________________________|____________|
Spleen | + + + + + | 55 |
Leukemia Granulocytic | | 1 |
Lymphoma Malignant | | 2 |
Capsule, Carcinoma, Metastatic, | | |
Uterus | | 1 |
|__________________________________________________________________________|____________|
Thymus | + + + + + | 52 |
Lymphoma Malignant | | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + | 55 |
Carcinoma | X | 6 |
Carcinoma, Multiple | X | 1 |
Fibroadenoma | | 17 |
Fibroadenoma, Multiple | X X | 14 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 30
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| | |
DAY ON TEST | 2| 8| 2| 2| 2| | |
| 2| 0| 9| 7| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| | A |
30 NG/KG | 9| 9| 9| 9| 9| | L |
| 3| 4| 5| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
| | |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Skin | + + + + + | 55 |
Fibroma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + | 55 |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Rhabdomyosarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + | 55 |
Leukemia Granulocytic | | 1 |
Meninges, Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + | 55 |
Alveolar/Bronchiolar Carcinoma | | 1 |
Leukemia Granulocytic | | 1 |
Lymphoma Malignant | | 2 |
Squamous Cell Carcinoma, Metastatic, | | |
Oral Mucosa | | 1 |
|__________________________________________________________________________|____________|
Nose | + + + + + | 54 |
|__________________________________________________________________________|____________|
Trachea | + + + + + | 55 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 31
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| | |
DAY ON TEST | 2| 8| 2| 2| 2| | |
| 2| 0| 9| 7| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| | A |
30 NG/KG | 9| 9| 9| 9| 9| | L |
| 3| 4| 5| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Eye | + + + + + | 55 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + | 53 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + | 55 |
Lymphoma Malignant | | 2 |
Nephroblastoma | | 2 |
Stromal Nephroma | | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 54 |
Serosa, Carcinoma, Metastatic, Uterus| | 1 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + | 55 |
Leukemia Granulocytic | | 1 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 32
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 6| 5| 7| 7| 6| 3| 7| 7| 3| 5| 5| 7|
DAY ON TEST | 2| 5| 2| 2| 2| 5| 2| 5| 0| 2| 2| 2| 2| 7| 8| 2| 2| 5| 7| 2| 2| 0| 5| 3| 0|
| 7| 1| 9| 9| 9| 3| 7| 1| 2| 7| 9| 8| 9| 8| 6| 8| 8| 3| 6| 7| 8| 0| 4| 1| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100 | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|
NG/KG | 1| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 1| 2| 4| 1| 2| 3| 4| 5| 6| 7| 9|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leiomyosarcoma | X |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Islets, | |
Pancreatic | X |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Islets, | |
Pancreatic | X |
Cholangiocarcinoma | |
Hepatocellular Adenoma | X |
Schwannoma Malignant, Metastatic, | |
Heart | X |
|__________________________________________________________________________|
Mesentery | + + |
Carcinoma, Metastatic, Islets, | |
Pancreatic | X |
|__________________________________________________________________________|
Oral Mucosa | + +|
Gingival, Squamous Cell Carcinoma | X |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 33
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 6| 5| 7| 7| 6| 3| 7| 7| 3| 5| 5| 7|
DAY ON TEST | 2| 5| 2| 2| 2| 5| 2| 5| 0| 2| 2| 2| 2| 7| 8| 2| 2| 5| 7| 2| 2| 0| 5| 3| 0|
| 7| 1| 9| 9| 9| 3| 7| 1| 2| 7| 9| 8| 9| 8| 6| 8| 8| 3| 6| 7| 8| 0| 4| 1| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100 | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|
NG/KG | 1| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 1| 2| 4| 1| 2| 3| 4| 5| 6| 7| 9|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Schwannoma Malignant, Metastatic, | |
Heart | X |
|__________________________________________________________________________|
Tooth | + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Schwannoma Malignant | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Schwannoma Malignant, Metastatic, | |
Heart | X |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Malignant | X|
Pheochromocytoma Benign | X X X X |
Schwannoma Malignant, Metastatic, | |
Heart | X |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M + + + + M + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X |
Pars Intermedia, Adenoma | |
__________________________________________|__________________________________________________________________________|
Page 34
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 6| 5| 7| 7| 6| 3| 7| 7| 3| 5| 5| 7|
DAY ON TEST | 2| 5| 2| 2| 2| 5| 2| 5| 0| 2| 2| 2| 2| 7| 8| 2| 2| 5| 7| 2| 2| 0| 5| 3| 0|
| 7| 1| 9| 9| 9| 3| 7| 1| 2| 7| 9| 8| 9| 8| 6| 8| 8| 3| 6| 7| 8| 0| 4| 1| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100 | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|
NG/KG | 1| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 1| 2| 4| 1| 2| 3| 4| 5| 6| 7| 9|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | X |
C-Cell, Adenoma | X X X X X X |
C-Cell, Carcinoma | X X|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + M +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa-Theca Tumor Malignant | X |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
Polyp Stromal | X X X |
Squamous Cell Papilloma | X |
|__________________________________________________________________________|
Vagina | |
Squamous Cell Carcinoma | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + + |
Mediastinal, Carcinoma, Metastatic, | |
Islets, Pancreatic | X |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 35
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 6| 5| 7| 7| 6| 3| 7| 7| 3| 5| 5| 7|
DAY ON TEST | 2| 5| 2| 2| 2| 5| 2| 5| 0| 2| 2| 2| 2| 7| 8| 2| 2| 5| 7| 2| 2| 0| 5| 3| 0|
| 7| 1| 9| 9| 9| 3| 7| 1| 2| 7| 9| 8| 9| 8| 6| 8| 8| 3| 6| 7| 8| 0| 4| 1| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100 | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|
NG/KG | 1| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 1| 2| 4| 1| 2| 3| 4| 5| 6| 7| 9|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Schwannoma Malignant, Metastatic, | |
Heart | X |
|__________________________________________________________________________|
Thymus | + + + + M + M + + + M + + M + + + + M M + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Carcinoma | X X X X X X |
Fibroadenoma | X X X X X X X |
Fibroadenoma, Multiple | X X X X X X X X X|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | X |
Subcutaneous Tissue, Fibroma, | |
Multiple | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + |
Carcinoma, Metastatic, Islets, | |
Pancreatic | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Medulloblastoma Mal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Islets, | |
__________________________________________|__________________________________________________________________________|
Page 36
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 6| 5| 7| 7| 6| 3| 7| 7| 3| 5| 5| 7|
DAY ON TEST | 2| 5| 2| 2| 2| 5| 2| 5| 0| 2| 2| 2| 2| 7| 8| 2| 2| 5| 7| 2| 2| 0| 5| 3| 0|
| 7| 1| 9| 9| 9| 3| 7| 1| 2| 7| 9| 8| 9| 8| 6| 8| 8| 3| 6| 7| 8| 0| 4| 1| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100 | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|
NG/KG | 1| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 1| 2| 4| 1| 2| 3| 4| 5| 6| 7| 9|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Pancreatic | X |
Carcinoma, Metastatic, Mammary Gland | |
Schwannoma Malignant, Metastatic, | |
Heart | X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephroblastoma | |
Schwannoma Malignant, Metastatic, | |
Heart | X |
|__________________________________________________________________________|
Ureter | + |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 37
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 6| 6| 7| 5| 1| 7| 7| 3| 6| 7| 7| 6| 7| 7| 4| 5| 7| 6| 5| 5|
DAY ON TEST | 2| 2| 2| 2| 2| 8| 5| 2| 3| 8| 2| 2| 2| 5| 2| 2| 2| 2| 0| 9| 0| 2| 5| 5| 4|
| 9| 9| 8| 9| 7| 8| 2| 8| 3| 8| 7| 7| 8| 1| 7| 9| 1| 7| 9| 8| 9| 7| 9| 5| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|
NG/KG | 0| 6| 7| 8| 9| 1| 2| 3| 4| 7| 1| 2| 3| 4| 5| 1| 2| 3| 4| 6| 7| 8| 0| 3| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leiomyosarcoma | |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Islets, | |
Pancreatic | |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Islets, | |
Pancreatic | |
Cholangiocarcinoma | |
Hepatocellular Adenoma | |
Schwannoma Malignant, Metastatic, | |
Heart | |
|__________________________________________________________________________|
Mesentery | + + |
Carcinoma, Metastatic, Islets, | |
Pancreatic | |
|__________________________________________________________________________|
Oral Mucosa | + |
Gingival, Squamous Cell Carcinoma | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 38
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 6| 6| 7| 5| 1| 7| 7| 3| 6| 7| 7| 6| 7| 7| 4| 5| 7| 6| 5| 5|
DAY ON TEST | 2| 2| 2| 2| 2| 8| 5| 2| 3| 8| 2| 2| 2| 5| 2| 2| 2| 2| 0| 9| 0| 2| 5| 5| 4|
| 9| 9| 8| 9| 7| 8| 2| 8| 3| 8| 7| 7| 8| 1| 7| 9| 1| 7| 9| 8| 9| 7| 9| 5| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|
NG/KG | 0| 6| 7| 8| 9| 1| 2| 3| 4| 7| 1| 2| 3| 4| 5| 1| 2| 3| 4| 6| 7| 8| 0| 3| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Schwannoma Malignant, Metastatic, | |
Heart | |
|__________________________________________________________________________|
Tooth | + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Schwannoma Malignant | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Schwannoma Malignant, Metastatic, | |
Heart | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | |
Schwannoma Malignant, Metastatic, | |
Heart | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
|__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + + + M +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X |
Pars Intermedia, Adenoma | X |
__________________________________________|__________________________________________________________________________|
Page 39
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 6| 6| 7| 5| 1| 7| 7| 3| 6| 7| 7| 6| 7| 7| 4| 5| 7| 6| 5| 5|
DAY ON TEST | 2| 2| 2| 2| 2| 8| 5| 2| 3| 8| 2| 2| 2| 5| 2| 2| 2| 2| 0| 9| 0| 2| 5| 5| 4|
| 9| 9| 8| 9| 7| 8| 2| 8| 3| 8| 7| 7| 8| 1| 7| 9| 1| 7| 9| 8| 9| 7| 9| 5| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|
NG/KG | 0| 6| 7| 8| 9| 1| 2| 3| 4| 7| 1| 2| 3| 4| 5| 1| 2| 3| 4| 6| 7| 8| 0| 3| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | X X |
C-Cell, Adenoma | X X X X X X|
C-Cell, Carcinoma | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa-Theca Tumor Malignant | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
Polyp Stromal | X X X |
Squamous Cell Papilloma | |
|__________________________________________________________________________|
Vagina | + |
Squamous Cell Carcinoma | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + |
Mediastinal, Carcinoma, Metastatic, | |
Islets, Pancreatic | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 40
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 6| 6| 7| 5| 1| 7| 7| 3| 6| 7| 7| 6| 7| 7| 4| 5| 7| 6| 5| 5|
DAY ON TEST | 2| 2| 2| 2| 2| 8| 5| 2| 3| 8| 2| 2| 2| 5| 2| 2| 2| 2| 0| 9| 0| 2| 5| 5| 4|
| 9| 9| 8| 9| 7| 8| 2| 8| 3| 8| 7| 7| 8| 1| 7| 9| 1| 7| 9| 8| 9| 7| 9| 5| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|
NG/KG | 0| 6| 7| 8| 9| 1| 2| 3| 4| 7| 1| 2| 3| 4| 5| 1| 2| 3| 4| 6| 7| 8| 0| 3| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Schwannoma Malignant, Metastatic, | |
Heart | |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Carcinoma | X X |
Fibroadenoma | X X X X X X X X X X X X|
Fibroadenoma, Multiple | X X X X X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | |
Subcutaneous Tissue, Fibroma, | |
Multiple | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | |
Carcinoma, Metastatic, Islets, | |
Pancreatic | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Medulloblastoma Mal | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Islets, | |
__________________________________________|__________________________________________________________________________|
Page 41
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 6| 6| 7| 5| 1| 7| 7| 3| 6| 7| 7| 6| 7| 7| 4| 5| 7| 6| 5| 5|
DAY ON TEST | 2| 2| 2| 2| 2| 8| 5| 2| 3| 8| 2| 2| 2| 5| 2| 2| 2| 2| 0| 9| 0| 2| 5| 5| 4|
| 9| 9| 8| 9| 7| 8| 2| 8| 3| 8| 7| 7| 8| 1| 7| 9| 1| 7| 9| 8| 9| 7| 9| 5| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
100 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|
NG/KG | 0| 6| 7| 8| 9| 1| 2| 3| 4| 7| 1| 2| 3| 4| 5| 1| 2| 3| 4| 6| 7| 8| 0| 3| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Pancreatic | |
Carcinoma, Metastatic, Mammary Gland | X |
Schwannoma Malignant, Metastatic, | |
Heart | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephroblastoma | |
Schwannoma Malignant, Metastatic, | |
Heart | |
|__________________________________________________________________________|
Ureter | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 42
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
__________________________________________________________________________________________________________________________________
| 7| 2| 7| | |
DAY ON TEST | 2| 3| 2| | |
| 7| 6| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
100 | 9| 9| 9| | L |
NG/KG | 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 52 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 53 |
Leiomyosarcoma | X | 2 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 52 |
Carcinoma, Metastatic, Islets, | | |
Pancreatic | | 1 |
|__________________________________________________________________________|____________|
Liver | + + + | 53 |
Carcinoma, Metastatic, Islets, | | |
Pancreatic | | 1 |
Cholangiocarcinoma | X | 1 |
Hepatocellular Adenoma | | 1 |
Schwannoma Malignant, Metastatic, | | |
Heart | | 1 |
|__________________________________________________________________________|____________|
Mesentery | | 4 |
Carcinoma, Metastatic, Islets, | | |
Pancreatic | | 1 |
|__________________________________________________________________________|____________|
Oral Mucosa | | 3 |
Gingival, Squamous Cell Carcinoma | | 1 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 43
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
__________________________________________________________________________________________________________________________________
| 7| 2| 7| | |
DAY ON TEST | 2| 3| 2| | |
| 7| 6| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
100 | 9| 9| 9| | L |
NG/KG | 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Pancreas | + + + | 53 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + | 53 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 53 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 53 |
Schwannoma Malignant, Metastatic, | | |
Heart | | 1 |
|__________________________________________________________________________|____________|
Tooth | | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + | 53 |
|__________________________________________________________________________|____________|
Heart | + + + | 53 |
Schwannoma Malignant | | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 53 |
Adenoma | | 1 |
Schwannoma Malignant, Metastatic, | | |
Heart | | 1 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 53 |
Pheochromocytoma Malignant | | 1 |
Pheochromocytoma Benign | | 4 |
Schwannoma Malignant, Metastatic, | | |
Heart | | 1 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 44
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
__________________________________________________________________________________________________________________________________
| 7| 2| 7| | |
DAY ON TEST | 2| 3| 2| | |
| 7| 6| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
100 | 9| 9| 9| | L |
NG/KG | 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
| | |
Islets, Pancreatic | + + + | 53 |
Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + | 48 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + | 53 |
Pars Distalis, Adenoma | | 20 |
Pars Intermedia, Adenoma | | 1 |
|__________________________________________________________________________|____________|
Thyroid Gland | + A + | 52 |
Bilateral, C-Cell, Adenoma | | 3 |
C-Cell, Adenoma | | 12 |
C-Cell, Carcinoma | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + | 52 |
|__________________________________________________________________________|____________|
Ovary | + + + | 53 |
Granulosa-Theca Tumor Malignant | | 1 |
|__________________________________________________________________________|____________|
Uterus | + + + | 53 |
Carcinoma | | 1 |
Polyp Stromal | X | 7 |
Squamous Cell Papilloma | | 1 |
|__________________________________________________________________________|____________|
Vagina | | 1 |
Squamous Cell Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 45
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
__________________________________________________________________________________________________________________________________
| 7| 2| 7| | |
DAY ON TEST | 2| 3| 2| | |
| 7| 6| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
100 | 9| 9| 9| | L |
NG/KG | 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + | 53 |
|__________________________________________________________________________|____________|
Lymph Node | | 6 |
Mediastinal, Carcinoma, Metastatic, | | |
Islets, Pancreatic | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 51 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 52 |
|__________________________________________________________________________|____________|
Spleen | + + + | 52 |
Schwannoma Malignant, Metastatic, | | |
Heart | | 1 |
|__________________________________________________________________________|____________|
Thymus | M + + | 46 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + | 53 |
Adenoma | | 2 |
Carcinoma | X | 9 |
Fibroadenoma | X X | 21 |
Fibroadenoma, Multiple | | 14 |
|__________________________________________________________________________|____________|
Skin | + + + | 53 |
Keratoacanthoma | | 1 |
Subcutaneous Tissue, Fibroma, | | |
Multiple | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + | 53 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 46
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
__________________________________________________________________________________________________________________________________
| 7| 2| 7| | |
DAY ON TEST | 2| 3| 2| | |
| 7| 6| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
100 | 9| 9| 9| | L |
NG/KG | 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Carcinoma, Metastatic, Islets, | | |
Pancreatic | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + | 53 |
Medulloblastoma Mal | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + | 53 |
Carcinoma, Metastatic, Islets, | | |
Pancreatic | | 1 |
Carcinoma, Metastatic, Mammary Gland | | 1 |
Schwannoma Malignant, Metastatic, | | |
Heart | | 1 |
|__________________________________________________________________________|____________|
Nose | + + + | 52 |
|__________________________________________________________________________|____________|
Trachea | + + + | 53 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + | 53 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + | 53 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + | 53 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 47
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
__________________________________________________________________________________________________________________________________
| 7| 2| 7| | |
DAY ON TEST | 2| 3| 2| | |
| 7| 6| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| | A |
100 | 9| 9| 9| | L |
NG/KG | 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
| | |
Nephroblastoma | X | 1 |
Schwannoma Malignant, Metastatic, | | |
Heart | | 1 |
|__________________________________________________________________________|____________|
Ureter | | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + | 53 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + | 53 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 48
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 7| 7| 5| 5| 4| 7| 6| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 5| 4| 6| 7| 5| 7| 6| 6|
DAY ON TEST | 2| 2| 9| 5| 0| 2| 6| 6| 2| 2| 2| 9| 2| 2| 5| 2| 0| 7| 4| 0| 2| 7| 2| 5| 5|
| 7| 7| 2| 9| 5| 7| 0| 0| 9| 7| 8| 5| 8| 7| 8| 9| 0| 4| 8| 4| 7| 6| 8| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
175 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 4|
NG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 3| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + M + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + M + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | |
Lymphoma Malignant | X |
|__________________________________________________________________________|
Mesentery | + + |
|__________________________________________________________________________|
Oral Mucosa | + + |
Gingival, Squamous Cell Carcinoma | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Carcinoma | X |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tooth | + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 49
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 7| 7| 5| 5| 4| 7| 6| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 5| 4| 6| 7| 5| 7| 6| 6|
DAY ON TEST | 2| 2| 9| 5| 0| 2| 6| 6| 2| 2| 2| 9| 2| 2| 5| 2| 0| 7| 4| 0| 2| 7| 2| 5| 5|
| 7| 7| 2| 9| 5| 7| 0| 0| 9| 7| 8| 5| 8| 7| 8| 9| 0| 4| 8| 4| 7| 6| 8| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
175 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 4|
NG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 3| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X X |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
|__________________________________________________________________________|
Parathyroid Gland | + + + + M + + + + + + + + + + + + + + M + + + + M|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X|
Pars Distalis, Carcinoma | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | |
C-Cell, Adenoma | X X X X X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa Cell Tumor Benign | X |
__________________________________________|__________________________________________________________________________|
Page 50
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 7| 7| 5| 5| 4| 7| 6| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 5| 4| 6| 7| 5| 7| 6| 6|
DAY ON TEST | 2| 2| 9| 5| 0| 2| 6| 6| 2| 2| 2| 9| 2| 2| 5| 2| 0| 7| 4| 0| 2| 7| 2| 5| 5|
| 7| 7| 2| 9| 5| 7| 0| 0| 9| 7| 8| 5| 8| 7| 8| 9| 0| 4| 8| 4| 7| 6| 8| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
175 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 4|
NG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 3| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
Hemangiosarcoma | X |
Lymphoma Malignant | X |
Polyp Stromal | X X X |
Sarcoma Stromal | X |
Sarcoma Stromal, Multiple | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + + |
Lymphoma Malignant | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + M + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Thymus | + + + + + + + + + M + + + + + + + + + + + M + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X X |
Carcinoma, Multiple | X |
Fibroadenoma | X X X X X X X X |
Fibroadenoma, Multiple | X X X X X X X X X X X|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________|__________________________________________________________________________|
Page 51
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 7| 7| 5| 5| 4| 7| 6| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 5| 4| 6| 7| 5| 7| 6| 6|
DAY ON TEST | 2| 2| 9| 5| 0| 2| 6| 6| 2| 2| 2| 9| 2| 2| 5| 2| 0| 7| 4| 0| 2| 7| 2| 5| 5|
| 7| 7| 2| 9| 5| 7| 0| 0| 9| 7| 8| 5| 8| 7| 8| 9| 0| 4| 8| 4| 7| 6| 8| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
175 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 4|
NG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 3| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pituitary | |
Gland | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | |
Carcinoma, Metastatic, Mammary Gland | X |
Lymphoma Malignant | X |
Pheochromocytoma Malignant, | |
Metastatic, Adrenal Medulla | |
Mediastinum, Carcinoma, Metastatic, | |
Mammary Gland | X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephroblastoma | X |
Stromal Nephroma | X |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 52
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
__________________________________________|__________________________________________________________________________
| 7| 7| 5| 5| 4| 7| 6| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 5| 4| 6| 7| 5| 7| 6| 6|
DAY ON TEST | 2| 2| 9| 5| 0| 2| 6| 6| 2| 2| 2| 9| 2| 2| 5| 2| 0| 7| 4| 0| 2| 7| 2| 5| 5|
| 7| 7| 2| 9| 5| 7| 0| 0| 9| 7| 8| 5| 8| 7| 8| 9| 0| 4| 8| 4| 7| 6| 8| 8| 8|
_____________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
175 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 4|
NG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 3| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0|
_____________________________________________________________________________________________________________________
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________|__________________________________________________________________________|
Page 53
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 7| 4| 6| 7| 5| 4| 6| 6| 7| 5| 7| 7| 6| 7| 7| 5| 1| 7| 5| 6| 7| 4| 4| 7| 7|
DAY ON TEST | 2| 8| 5| 2| 4| 9| 0| 5| 2| 0| 2| 2| 6| 2| 2| 3| 2| 2| 7| 1| 2| 5| 8| 2| 2|
| 8| 1| 8| 0| 6| 6| 7| 9| 8| 0| 8| 7| 0| 7| 8| 0| 4| 9| 3| 1| 7| 4| 7| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
175 | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|
NG/KG | 1| 2| 4| 7| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + M + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + M + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + M + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X |
Lymphoma Malignant | |
|__________________________________________________________________________|
Mesentery | |
|__________________________________________________________________________|
Oral Mucosa | + + |
Gingival, Squamous Cell Carcinoma | X |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Carcinoma | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + M + + + + + + + + M + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tooth | + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 54
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 7| 4| 6| 7| 5| 4| 6| 6| 7| 5| 7| 7| 6| 7| 7| 5| 1| 7| 5| 6| 7| 4| 4| 7| 7|
DAY ON TEST | 2| 8| 5| 2| 4| 9| 0| 5| 2| 0| 2| 2| 6| 2| 2| 3| 2| 2| 7| 1| 2| 5| 8| 2| 2|
| 8| 1| 8| 0| 6| 6| 7| 9| 8| 0| 8| 7| 0| 7| 8| 0| 4| 9| 3| 1| 7| 4| 7| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
175 | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|
NG/KG | 1| 2| 4| 7| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
|__________________________________________________________________________|
Parathyroid Gland | + M + + + + + + + M + + + + + + + + M + + + + + M|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X|
Pars Distalis, Carcinoma | X |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + M + + + + + + + + M + + + + + +|
Bilateral, C-Cell, Adenoma | X X |
C-Cell, Adenoma | X X X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + M M + + + + + + + + M + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + M + + + + + + + + +|
Granulosa Cell Tumor Benign | |
__________________________________________|__________________________________________________________________________|
Page 55
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 7| 4| 6| 7| 5| 4| 6| 6| 7| 5| 7| 7| 6| 7| 7| 5| 1| 7| 5| 6| 7| 4| 4| 7| 7|
DAY ON TEST | 2| 8| 5| 2| 4| 9| 0| 5| 2| 0| 2| 2| 6| 2| 2| 3| 2| 2| 7| 1| 2| 5| 8| 2| 2|
| 8| 1| 8| 0| 6| 6| 7| 9| 8| 0| 8| 7| 0| 7| 8| 0| 4| 9| 3| 1| 7| 4| 7| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
175 | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|
NG/KG | 1| 2| 4| 7| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + M + + + + + + + + +|
Carcinoma | X |
Hemangiosarcoma | |
Lymphoma Malignant | |
Polyp Stromal | |
Sarcoma Stromal | |
Sarcoma Stromal, Multiple | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + |
Lymphoma Malignant | X |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + M + + + + + + + + M + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Thymus | M + + + + + + + + + + + + + + M + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
Carcinoma, Multiple | |
Fibroadenoma | X X X X X X X X X X X |
Fibroadenoma, Multiple | X X X X X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________|__________________________________________________________________________|
Page 56
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 7| 4| 6| 7| 5| 4| 6| 6| 7| 5| 7| 7| 6| 7| 7| 5| 1| 7| 5| 6| 7| 4| 4| 7| 7|
DAY ON TEST | 2| 8| 5| 2| 4| 9| 0| 5| 2| 0| 2| 2| 6| 2| 2| 3| 2| 2| 7| 1| 2| 5| 8| 2| 2|
| 8| 1| 8| 0| 6| 6| 7| 9| 8| 0| 8| 7| 0| 7| 8| 0| 4| 9| 3| 1| 7| 4| 7| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
175 | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|
NG/KG | 1| 2| 4| 7| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pituitary | |
Gland | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
Carcinoma, Metastatic, Mammary Gland | |
Lymphoma Malignant | |
Pheochromocytoma Malignant, | |
Metastatic, Adrenal Medulla | X |
Mediastinum, Carcinoma, Metastatic, | |
Mammary Gland | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephroblastoma | |
Stromal Nephroma | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + M + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 57
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
__________________________________________|__________________________________________________________________________
| 7| 4| 6| 7| 5| 4| 6| 6| 7| 5| 7| 7| 6| 7| 7| 5| 1| 7| 5| 6| 7| 4| 4| 7| 7|
DAY ON TEST | 2| 8| 5| 2| 4| 9| 0| 5| 2| 0| 2| 2| 6| 2| 2| 3| 2| 2| 7| 1| 2| 5| 8| 2| 2|
| 8| 1| 8| 0| 6| 6| 7| 9| 8| 0| 8| 7| 0| 7| 8| 0| 4| 9| 3| 1| 7| 4| 7| 9| 9|
_____________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
175 | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|
NG/KG | 1| 2| 4| 7| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2|
_____________________________________________________________________________________________________________________
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________|__________________________________________________________________________|
Page 58
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
__________________________________________________________________________________________________________________________________
| 3| 7| 4| | |
DAY ON TEST | 8| 2| 3| | |
| 5| 7| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
175 | 9| 9| 9| | L |
NG/KG | 3| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 52 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 51 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 51 |
|__________________________________________________________________________|____________|
Liver | + + + | 53 |
Hepatocellular Carcinoma | | 1 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Mesentery | | 2 |
|__________________________________________________________________________|____________|
Oral Mucosa | | 4 |
Gingival, Squamous Cell Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + | 53 |
Acinus, Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + | 51 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 53 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 53 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 59
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
__________________________________________________________________________________________________________________________________
| 3| 7| 4| | |
DAY ON TEST | 8| 2| 3| | |
| 5| 7| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
175 | 9| 9| 9| | L |
NG/KG | 3| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Tooth | + | 9 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + | 53 |
|__________________________________________________________________________|____________|
Heart | + + + | 53 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 53 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 53 |
Pheochromocytoma Malignant | | 1 |
Pheochromocytoma Benign | | 2 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 53 |
Adenoma | | 1 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + | 46 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + | 53 |
Pars Distalis, Adenoma | | 16 |
Pars Distalis, Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + | 51 |
Bilateral, C-Cell, Adenoma | | 2 |
C-Cell, Adenoma | X | 11 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 60
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
__________________________________________________________________________________________________________________________________
| 3| 7| 4| | |
DAY ON TEST | 8| 2| 3| | |
| 5| 7| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
175 | 9| 9| 9| | L |
NG/KG | 3| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + | 50 |
|__________________________________________________________________________|____________|
Ovary | + + + | 52 |
Granulosa Cell Tumor Benign | | 1 |
|__________________________________________________________________________|____________|
Uterus | + + + | 52 |
Carcinoma | | 1 |
Hemangiosarcoma | | 1 |
Lymphoma Malignant | | 1 |
Polyp Stromal | | 3 |
Sarcoma Stromal | | 1 |
Sarcoma Stromal, Multiple | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + | 53 |
|__________________________________________________________________________|____________|
Lymph Node | | 6 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 51 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 52 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Spleen | + + + | 53 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Thymus | + M + | 48 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 61
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
__________________________________________________________________________________________________________________________________
| 3| 7| 4| | |
DAY ON TEST | 8| 2| 3| | |
| 5| 7| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
175 | 9| 9| 9| | L |
NG/KG | 3| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
| | |
Mammary Gland | + + + | 53 |
Carcinoma | X | 4 |
Carcinoma, Multiple | | 1 |
Fibroadenoma | X X | 21 |
Fibroadenoma, Multiple | X | 17 |
|__________________________________________________________________________|____________|
Skin | + + + | 53 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + | 53 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + | 53 |
Carcinoma, Metastatic, Pituitary | | |
Gland | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + | 53 |
Alveolar/Bronchiolar Adenoma | | 1 |
Carcinoma, Metastatic, Mammary Gland | | 1 |
Lymphoma Malignant | | 1 |
Pheochromocytoma Malignant, | | |
Metastatic, Adrenal Medulla | | 1 |
Mediastinum, Carcinoma, Metastatic, | | |
Mammary Gland | | 1 |
|__________________________________________________________________________|____________|
Nose | + + + | 53 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 62
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
__________________________________________________________________________________________________________________________________
| 3| 7| 4| | |
DAY ON TEST | 8| 2| 3| | |
| 5| 7| 6| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| | A |
175 | 9| 9| 9| | L |
NG/KG | 3| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
| | |
Trachea | + + + | 53 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + | 53 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + | 53 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + | 53 |
Nephroblastoma | | 1 |
Stromal Nephroma | | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + | 52 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + | 53 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 63
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 6| 7| 6| 6| 5| 6| 6| 7| 3| 7| 7| 6| 7| 6| 7| 7| 6| 7| 4| 6| 4| 7| 7| 7| 7|
DAY ON TEST | 6| 1| 3| 8| 4| 0| 0| 2| 0| 2| 0| 0| 2| 8| 2| 2| 5| 2| 5| 6| 0| 2| 2| 2| 2|
| 2| 9| 0| 8| 1| 7| 7| 7| 1| 7| 9| 7| 7| 0| 7| 9| 8| 7| 4| 5| 3| 9| 7| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
300 | 0| 0| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
NG/KG | 6| 9| 6| 7| 9| 1| 2| 3| 4| 5| 6| 7| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cholangiocarcinoma | X X X X|
Hepatocellular Adenoma | X |
Lymphoma Malignant | |
|__________________________________________________________________________|
Mesentery | + + + |
|__________________________________________________________________________|
Oral Mucosa | + |
Gingival, Squamous Cell Carcinoma | X |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
Acinus, Adenoma | X |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + M + + + + + + + + + + +|
Carcinoma | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________|__________________________________________________________________________|
Page 64
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 6| 7| 6| 6| 5| 6| 6| 7| 3| 7| 7| 6| 7| 6| 7| 7| 6| 7| 4| 6| 4| 7| 7| 7| 7|
DAY ON TEST | 6| 1| 3| 8| 4| 0| 0| 2| 0| 2| 0| 0| 2| 8| 2| 2| 5| 2| 5| 6| 0| 2| 2| 2| 2|
| 2| 9| 0| 8| 1| 7| 7| 7| 1| 7| 9| 7| 7| 0| 7| 9| 8| 7| 4| 5| 3| 9| 7| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
300 | 0| 0| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
NG/KG | 6| 9| 6| 7| 9| 1| 2| 3| 4| 5| 6| 7| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
|__________________________________________________________________________|
Tooth | + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
Schwannoma Benign | X |
Schwannoma Malignant | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
Lymphoma Malignant | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Complex | X |
Pheochromocytoma Benign | X |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + M + + M + + + + + + + M|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | X X X |
C-Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 6| 7| 6| 6| 5| 6| 6| 7| 3| 7| 7| 6| 7| 6| 7| 7| 6| 7| 4| 6| 4| 7| 7| 7| 7|
DAY ON TEST | 6| 1| 3| 8| 4| 0| 0| 2| 0| 2| 0| 0| 2| 8| 2| 2| 5| 2| 5| 6| 0| 2| 2| 2| 2|
| 2| 9| 0| 8| 1| 7| 7| 7| 1| 7| 9| 7| 7| 0| 7| 9| 8| 7| 4| 5| 3| 9| 7| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
300 | 0| 0| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
NG/KG | 6| 9| 6| 7| 9| 1| 2| 3| 4| 5| 6| 7| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + M + + + + +|
Lymphoma Malignant | |
Sarcoma Stromal, Metastatic, Uterus | X |
|__________________________________________________________________________|
Oviduct | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Stromal | X X X X X X X|
Sarcoma Stromal | X |
Cervix, Sarcoma Stromal | |
Cervix, Schwannoma Malignant | X |
|__________________________________________________________________________|
Vagina | + |
Sarcoma Stromal, Metastatic, Uterus | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Lymph Node | + + |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + M M + + + M + M + + + +|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 6| 7| 6| 6| 5| 6| 6| 7| 3| 7| 7| 6| 7| 6| 7| 7| 6| 7| 4| 6| 4| 7| 7| 7| 7|
DAY ON TEST | 6| 1| 3| 8| 4| 0| 0| 2| 0| 2| 0| 0| 2| 8| 2| 2| 5| 2| 5| 6| 0| 2| 2| 2| 2|
| 2| 9| 0| 8| 1| 7| 7| 7| 1| 7| 9| 7| 7| 0| 7| 9| 8| 7| 4| 5| 3| 9| 7| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
300 | 0| 0| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
NG/KG | 6| 9| 6| 7| 9| 1| 2| 3| 4| 5| 6| 7| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Fibroadenoma | X X X X X X X X X X X X |
Fibroadenoma, Multiple | X X X X X X|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma Malignant | X |
Medulloblastoma Mal | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cystic Keratinizing Epithelioma | |
Lymphoma Malignant | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peritracheal Tissue, Schwannoma | |
Malignant, Metastatic, Heart | X |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | + |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 67
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 6| 7| 6| 6| 5| 6| 6| 7| 3| 7| 7| 6| 7| 6| 7| 7| 6| 7| 4| 6| 4| 7| 7| 7| 7|
DAY ON TEST | 6| 1| 3| 8| 4| 0| 0| 2| 0| 2| 0| 0| 2| 8| 2| 2| 5| 2| 5| 6| 0| 2| 2| 2| 2|
| 2| 9| 0| 8| 1| 7| 7| 7| 1| 7| 9| 7| 7| 0| 7| 9| 8| 7| 4| 5| 3| 9| 7| 9| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
300 | 0| 0| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
NG/KG | 6| 9| 6| 7| 9| 1| 2| 3| 4| 5| 6| 7| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lacrimal Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
Stromal Nephroma | X |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________|__________________________________________________________________________|
Page 68
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 3| 6| 1| 5| 6| 7| 5| 7| 7| 6| 5| 7| 6| 6| 5| 6| 2| 0| 3| 7| 6|
DAY ON TEST | 2| 5| 2| 5| 3| 5| 6| 3| 5| 2| 4| 2| 2| 4| 3| 1| 1| 1| 9| 8| 4| 4| 2| 2| 4|
| 7| 4| 7| 9| 1| 8| 3| 1| 9| 9| 6| 7| 9| 5| 1| 5| 8| 8| 9| 8| 7| 0| 8| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
300 | 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|
NG/KG | 5| 1| 3| 4| 9| 1| 2| 3| 5| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cholangiocarcinoma | X |
Hepatocellular Adenoma | X |
Lymphoma Malignant | X |
|__________________________________________________________________________|
Mesentery | + + + |
|__________________________________________________________________________|
Oral Mucosa | + |
Gingival, Squamous Cell Carcinoma | X |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
Acinus, Adenoma | X |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________|__________________________________________________________________________|
Page 69
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 3| 6| 1| 5| 6| 7| 5| 7| 7| 6| 5| 7| 6| 6| 5| 6| 2| 0| 3| 7| 6|
DAY ON TEST | 2| 5| 2| 5| 3| 5| 6| 3| 5| 2| 4| 2| 2| 4| 3| 1| 1| 1| 9| 8| 4| 4| 2| 2| 4|
| 7| 4| 7| 9| 1| 8| 3| 1| 9| 9| 6| 7| 9| 5| 1| 5| 8| 8| 9| 8| 7| 0| 8| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
300 | 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|
NG/KG | 5| 1| 3| 4| 9| 1| 2| 3| 5| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
|__________________________________________________________________________|
Tooth | + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
Schwannoma Benign | |
Schwannoma Malignant | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
Lymphoma Malignant | X |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Complex | |
Pheochromocytoma Benign | X |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X X X |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | |
C-Cell, Adenoma | X X X X X|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
Page 70
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 3| 6| 1| 5| 6| 7| 5| 7| 7| 6| 5| 7| 6| 6| 5| 6| 2| 0| 3| 7| 6|
DAY ON TEST | 2| 5| 2| 5| 3| 5| 6| 3| 5| 2| 4| 2| 2| 4| 3| 1| 1| 1| 9| 8| 4| 4| 2| 2| 4|
| 7| 4| 7| 9| 1| 8| 3| 1| 9| 9| 6| 7| 9| 5| 1| 5| 8| 8| 9| 8| 7| 0| 8| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
300 | 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|
NG/KG | 5| 1| 3| 4| 9| 1| 2| 3| 5| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
Sarcoma Stromal, Metastatic, Uterus | |
|__________________________________________________________________________|
Oviduct | + |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Polyp Stromal | X |
Sarcoma Stromal | |
Cervix, Sarcoma Stromal | X |
Cervix, Schwannoma Malignant | |
|__________________________________________________________________________|
Vagina | |
Sarcoma Stromal, Metastatic, Uterus | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Lymph Node | + + |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Thymus | + + + + + + M + M + + M + + + + + M M + + + M + +|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
Page 71
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 3| 6| 1| 5| 6| 7| 5| 7| 7| 6| 5| 7| 6| 6| 5| 6| 2| 0| 3| 7| 6|
DAY ON TEST | 2| 5| 2| 5| 3| 5| 6| 3| 5| 2| 4| 2| 2| 4| 3| 1| 1| 1| 9| 8| 4| 4| 2| 2| 4|
| 7| 4| 7| 9| 1| 8| 3| 1| 9| 9| 6| 7| 9| 5| 1| 5| 8| 8| 9| 8| 7| 0| 8| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
300 | 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|
NG/KG | 5| 1| 3| 4| 9| 1| 2| 3| 5| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
Fibroadenoma | X X X X X X X X X X X X|
Fibroadenoma, Multiple | X X X X X X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma Malignant | |
Medulloblastoma Mal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cystic Keratinizing Epithelioma | X |
Lymphoma Malignant | X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peritracheal Tissue, Schwannoma | |
Malignant, Metastatic, Heart | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 72
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 7| 5| 7| 6| 3| 6| 1| 5| 6| 7| 5| 7| 7| 6| 5| 7| 6| 6| 5| 6| 2| 0| 3| 7| 6|
DAY ON TEST | 2| 5| 2| 5| 3| 5| 6| 3| 5| 2| 4| 2| 2| 4| 3| 1| 1| 1| 9| 8| 4| 4| 2| 2| 4|
| 7| 4| 7| 9| 1| 8| 3| 1| 9| 9| 6| 7| 9| 5| 1| 5| 8| 8| 9| 8| 7| 0| 8| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
300 | 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|
NG/KG | 5| 1| 3| 4| 9| 1| 2| 3| 5| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
Stromal Nephroma | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________|__________________________________________________________________________|
Page 73
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
__________________________________________________________________________________________________________________________________
| 7| 5| 7| | |
DAY ON TEST | 2| 5| 2| | |
| 2| 4| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| | A |
300 | 9| 9| 9| | L |
NG/KG | 0| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 53 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 53 |
|__________________________________________________________________________|____________|
Liver | + + + | 53 |
Cholangiocarcinoma | | 5 |
Hepatocellular Adenoma | | 2 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Mesentery | + | 7 |
|__________________________________________________________________________|____________|
Oral Mucosa | | 2 |
Gingival, Squamous Cell Carcinoma | | 2 |
|__________________________________________________________________________|____________|
Pancreas | + + + | 53 |
Lymphoma Malignant | | 1 |
Acinus, Adenoma | | 2 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + | 52 |
Carcinoma | | 1 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 74
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
__________________________________________________________________________________________________________________________________
| 7| 5| 7| | |
DAY ON TEST | 2| 5| 2| | |
| 2| 4| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| | A |
300 | 9| 9| 9| | L |
NG/KG | 0| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Stomach, Forestomach | + + + | 53 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 53 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Tooth | + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + | 53 |
|__________________________________________________________________________|____________|
Heart | + + + | 53 |
Lymphoma Malignant | | 1 |
Schwannoma Benign | | 1 |
Schwannoma Malignant | | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 53 |
Carcinoma | | 1 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 53 |
Pheochromocytoma Complex | | 1 |
Pheochromocytoma Benign | | 2 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 53 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + | 49 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + | 53 |
Pars Distalis, Adenoma | X X | 22 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 75
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
__________________________________________________________________________________________________________________________________
| 7| 5| 7| | |
DAY ON TEST | 2| 5| 2| | |
| 2| 4| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| | A |
300 | 9| 9| 9| | L |
NG/KG | 0| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + | 52 |
Bilateral, C-Cell, Adenoma | | 3 |
C-Cell, Adenoma | X X | 9 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + | 53 |
|__________________________________________________________________________|____________|
Ovary | + + + | 52 |
Lymphoma Malignant | | 1 |
Sarcoma Stromal, Metastatic, Uterus | | 1 |
|__________________________________________________________________________|____________|
Oviduct | | 1 |
|__________________________________________________________________________|____________|
Uterus | + + + | 53 |
Polyp Stromal | | 8 |
Sarcoma Stromal | | 1 |
Cervix, Sarcoma Stromal | | 1 |
Cervix, Schwannoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Vagina | | 1 |
Sarcoma Stromal, Metastatic, Uterus | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + | 53 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 76
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
__________________________________________________________________________________________________________________________________
| 7| 5| 7| | |
DAY ON TEST | 2| 5| 2| | |
| 2| 4| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| | A |
300 | 9| 9| 9| | L |
NG/KG | 0| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymph Node | | 4 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 52 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 53 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Spleen | + + + | 53 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Thymus | M + + | 41 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + | 53 |
Adenoma | | 1 |
Fibroadenoma | X X | 26 |
Fibroadenoma, Multiple | X | 13 |
|__________________________________________________________________________|____________|
Skin | + + + | 53 |
Fibrous Histiocytoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + | 53 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + | 53 |
Astrocytoma Malignant | | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 77
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
__________________________________________________________________________________________________________________________________
| 7| 5| 7| | |
DAY ON TEST | 2| 5| 2| | |
| 2| 4| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| | A |
300 | 9| 9| 9| | L |
NG/KG | 0| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
| | |
Medulloblastoma Mal | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + | 53 |
Cystic Keratinizing Epithelioma | | 1 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Nose | + + + | 52 |
|__________________________________________________________________________|____________|
Trachea | + + + | 53 |
Peritracheal Tissue, Schwannoma | | |
Malignant, Metastatic, Heart | | 1 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | | 1 |
|__________________________________________________________________________|____________|
Eye | + + + | 53 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + | 53 |
|__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + | 53 |
Lymphoma Malignant | | 1 |
Stromal Nephroma | | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + | 52 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + | 53 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 78
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
__________________________________________________________________________________________________________________________________
| 7| 5| 7| | |
DAY ON TEST | 2| 5| 2| | |
| 2| 4| 7| | |
_____________________________________________________________________________________________________________________ T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| | A |
300 | 9| 9| 9| | L |
NG/KG | 0| 7| 8| | |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Lymphoma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 79
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 5| 7| 3| 7| 6| 1| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7|
DAY ON TEST | 2| 2| 1| 7| 3| 2| 2| 2| 1| 8| 2| 2| 2| 2| 6| 2| 1| 2| 5| 2| 2| 5| 3| 2| 2|
| 8| 7| 8| 3| 5| 7| 0| 8| 8| 5| 8| 8| 7| 7| 7| 2| 4| 8| 1| 8| 8| 1| 7| 2| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
550 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
NG/KG | 1| 2| 3| 4| 5| 6| 7| 9| 1| 9| 1| 2| 4| 5| 1| 2| 4| 5| 7| 8| 9| 0| 6| 7| 9|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + M + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + M + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + M + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + M + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + M + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + M + + + + + + + +|
Cholangiocarcinoma | X X |
Cholangiocarcinoma, Multiple | X X X|
Cholangioma | |
Hepatocellular Adenoma | X X |
|__________________________________________________________________________|
Mesentery | + + + + + + +|
Sarcoma, Metastatic, Kidney | X |
Sarcoma Stromal, Metastatic, Uterus | |
|__________________________________________________________________________|
Oral Mucosa | + + + + +|
Gingival, Squamous Cell Carcinoma | X|
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + M + + + + + + + +|
Sarcoma Stromal, Metastatic, Uterus | |
|__________________________________________________________________________|
Salivary Glands | + + M + M + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + M + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + M + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 80
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 5| 7| 3| 7| 6| 1| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7|
DAY ON TEST | 2| 2| 1| 7| 3| 2| 2| 2| 1| 8| 2| 2| 2| 2| 6| 2| 1| 2| 5| 2| 2| 5| 3| 2| 2|
| 8| 7| 8| 3| 5| 7| 0| 8| 8| 5| 8| 8| 7| 7| 7| 2| 4| 8| 1| 8| 8| 1| 7| 2| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
550 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
NG/KG | 1| 2| 3| 4| 5| 6| 7| 9| 1| 9| 1| 2| 4| 5| 1| 2| 4| 5| 7| 8| 9| 0| 6| 7| 9|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Tooth | + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + M + + + + + + + + + + + M + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + M + + + + + + + +|
Adenoma | X |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + M + + + + + + + +|
Pheochromocytoma Malignant | |
Pheochromocytoma Benign | X X |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + M + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + M + M + + + + + + M + M + + + + + + + + + + +|
Adenoma | X |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X|
Pars Distalis, Adenoma, Multiple | X |
Pars Distalis, Carcinoma | |
|__________________________________________________________________________|
Thyroid Gland | + + M + M + + + + + + + + + + + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | X |
C-Cell, Adenoma | X X X X |
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | + |
Carcinoma | X |
__________________________________________|__________________________________________________________________________|
Page 81
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 5| 7| 3| 7| 6| 1| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7|
DAY ON TEST | 2| 2| 1| 7| 3| 2| 2| 2| 1| 8| 2| 2| 2| 2| 6| 2| 1| 2| 5| 2| 2| 5| 3| 2| 2|
| 8| 7| 8| 3| 5| 7| 0| 8| 8| 5| 8| 8| 7| 7| 7| 2| 4| 8| 1| 8| 8| 1| 7| 2| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
550 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
NG/KG | 1| 2| 3| 4| 5| 6| 7| 9| 1| 9| 1| 2| 4| 5| 1| 2| 4| 5| 7| 8| 9| 0| 6| 7| 9|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + M + + + + + + + +|
Cystadenoma | X|
|__________________________________________________________________________|
Oviduct | + + |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + M + + + + + + + +|
Adenoma | |
Carcinoma | X |
Polyp Stromal | X |
Sarcoma Stromal | |
Schwannoma Malignant | |
Squamous Cell Papilloma | |
Cervix, Schwannoma Malignant | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + + + |
Lumbar, Sarcoma Stromal, Metastatic, | |
Uterus | |
Mediastinal, Carcinoma, Metastatic, | |
Thyroid Gland | X |
Pancreatic, Lymphoma Malignant | X |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + M + M + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + M + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + M + + + + + + + +|
Sarcoma Stromal, Metastatic, Uterus | |
|__________________________________________________________________________|
Thymus | + + + + M + M + + + + + + + + + M + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 5| 7| 3| 7| 6| 1| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7|
DAY ON TEST | 2| 2| 1| 7| 3| 2| 2| 2| 1| 8| 2| 2| 2| 2| 6| 2| 1| 2| 5| 2| 2| 5| 3| 2| 2|
| 8| 7| 8| 3| 5| 7| 0| 8| 8| 5| 8| 8| 7| 7| 7| 2| 4| 8| 1| 8| 8| 1| 7| 2| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
550 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
NG/KG | 1| 2| 3| 4| 5| 6| 7| 9| 1| 9| 1| 2| 4| 5| 1| 2| 4| 5| 7| 8| 9| 0| 6| 7| 9|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
Carcinoma | X |
Fibroadenoma | X X X X X X X X X X |
Fibroadenoma, Multiple | X X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma | X |
Squamous Cell Carcinoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pituitary | |
Gland | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + M + + + + + + + + + + + M + + + + + + + +|
Adenocarcinoma, Mucinous | X |
Cystic Keratinizing Epithelioma | X X |
Cystic Keratinizing Epithelioma, | |
Multiple | X X |
Sarcoma, Metastatic, Kidney | X |
Sarcoma Stromal, Metastatic, Uterus | |
Squamous Cell Carcinoma | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + M + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 83
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 7| 7| 6| 5| 5| 7| 3| 7| 6| 1| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7|
DAY ON TEST | 2| 2| 1| 7| 3| 2| 2| 2| 1| 8| 2| 2| 2| 2| 6| 2| 1| 2| 5| 2| 2| 5| 3| 2| 2|
| 8| 7| 8| 3| 5| 7| 0| 8| 8| 5| 8| 8| 7| 7| 7| 2| 4| 8| 1| 8| 8| 1| 7| 2| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
550 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|
NG/KG | 1| 2| 3| 4| 5| 6| 7| 9| 1| 9| 1| 2| 4| 5| 1| 2| 4| 5| 7| 8| 9| 0| 6| 7| 9|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Eye | + + M + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + M + + + + + + + +|
Stromal Nephroma | X |
Transitional Epithelium, Carcinoma | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________|__________________________________________________________________________|
Page 84
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 4| 7| 6| 5| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 3| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 9| 2| 7| 7| 2| 5| 2| 2| 7| 9| 2| 2| 1| 1| 2| 2| 2| 0| 0| 1| 4| 2| 1| 2| 2|
| 8| 7| 8| 4| 8| 4| 8| 9| 8| 9| 8| 7| 8| 4| 7| 8| 7| 0| 2| 4| 0| 7| 2| 7| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
550 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|
NG/KG | 0| 1| 2| 3| 5| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 1| 3| 4| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + M + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + M + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + M + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + M + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + M + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + M + + + + + + + + + +|
Cholangiocarcinoma | |
Cholangiocarcinoma, Multiple | X |
Cholangioma | X |
Hepatocellular Adenoma | X |
|__________________________________________________________________________|
Mesentery | + + + + + |
Sarcoma, Metastatic, Kidney | |
Sarcoma Stromal, Metastatic, Uterus | X |
|__________________________________________________________________________|
Oral Mucosa | + |
Gingival, Squamous Cell Carcinoma | X |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma Stromal, Metastatic, Uterus | X |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + M + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + M + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 85
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 4| 7| 6| 5| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 3| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 9| 2| 7| 7| 2| 5| 2| 2| 7| 9| 2| 2| 1| 1| 2| 2| 2| 0| 0| 1| 4| 2| 1| 2| 2|
| 8| 7| 8| 4| 8| 4| 8| 9| 8| 9| 8| 7| 8| 4| 7| 8| 7| 0| 2| 4| 0| 7| 2| 7| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
550 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|
NG/KG | 0| 1| 2| 3| 5| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 1| 3| 4| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Malignant | X |
Pheochromocytoma Benign | X X |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + M|
Adenoma | |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X|
Pars Distalis, Adenoma, Multiple | |
Pars Distalis, Carcinoma | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + A + + + + + + + + + +|
Bilateral, C-Cell, Adenoma | X |
C-Cell, Adenoma | X X X X X|
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | |
Carcinoma | |
__________________________________________|__________________________________________________________________________|
Page 86
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 4| 7| 6| 5| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 3| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 9| 2| 7| 7| 2| 5| 2| 2| 7| 9| 2| 2| 1| 1| 2| 2| 2| 0| 0| 1| 4| 2| 1| 2| 2|
| 8| 7| 8| 4| 8| 4| 8| 9| 8| 9| 8| 7| 8| 4| 7| 8| 7| 0| 2| 4| 0| 7| 2| 7| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
550 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|
NG/KG | 0| 1| 2| 3| 5| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 1| 3| 4| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cystadenoma | |
|__________________________________________________________________________|
Oviduct | + |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | |
Polyp Stromal | X X X |
Sarcoma Stromal | X |
Schwannoma Malignant | X |
Squamous Cell Papilloma | X |
Cervix, Schwannoma Malignant | X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + + |
Lumbar, Sarcoma Stromal, Metastatic, | |
Uterus | X |
Mediastinal, Carcinoma, Metastatic, | |
Thyroid Gland | |
Pancreatic, Lymphoma Malignant | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Sarcoma Stromal, Metastatic, Uterus | X |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + M + + + +|
_____________________________________________________________________________________________________________________|
Page 87
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 4| 7| 6| 5| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 3| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 9| 2| 7| 7| 2| 5| 2| 2| 7| 9| 2| 2| 1| 1| 2| 2| 2| 0| 0| 1| 4| 2| 1| 2| 2|
| 8| 7| 8| 4| 8| 4| 8| 9| 8| 9| 8| 7| 8| 4| 7| 8| 7| 0| 2| 4| 0| 7| 2| 7| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
550 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|
NG/KG | 0| 1| 2| 3| 5| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 1| 3| 4| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
Fibroadenoma | X X X X X X X X X X X X X |
Fibroadenoma, Multiple | X X X|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Histiocytoma | |
Squamous Cell Carcinoma | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Pituitary | |
Gland | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenocarcinoma, Mucinous | |
Cystic Keratinizing Epithelioma | X |
Cystic Keratinizing Epithelioma, | |
Multiple | X X X X X |
Sarcoma, Metastatic, Kidney | |
Sarcoma Stromal, Metastatic, Uterus | X |
Squamous Cell Carcinoma | X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 88
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 4| 7| 6| 5| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 3| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7|
DAY ON TEST | 9| 2| 7| 7| 2| 5| 2| 2| 7| 9| 2| 2| 1| 1| 2| 2| 2| 0| 0| 1| 4| 2| 1| 2| 2|
| 8| 7| 8| 4| 8| 4| 8| 9| 8| 9| 8| 7| 8| 4| 7| 8| 7| 0| 2| 4| 0| 7| 2| 7| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|
550 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|
NG/KG | 0| 1| 2| 3| 5| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 1| 3| 4| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Stromal Nephroma | |
Transitional Epithelium, Carcinoma | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________|__________________________________________________________________________|
Page 89
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
__________________________________________________________________________________________________________________________________
| 7| 7| 5| | |
DAY ON TEST | 2| 2| 8| | |
| 7| 9| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| | A |
550 | 8| 9| 9| | L |
NG/KG | 9| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + | 52 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 51 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 52 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 52 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 51 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 51 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 52 |
|__________________________________________________________________________|____________|
Liver | + + + | 51 |
Cholangiocarcinoma | | 2 |
Cholangiocarcinoma, Multiple | | 4 |
Cholangioma | | 1 |
Hepatocellular Adenoma | X | 4 |
|__________________________________________________________________________|____________|
Mesentery | + | 13 |
Sarcoma, Metastatic, Kidney | | 1 |
Sarcoma Stromal, Metastatic, Uterus | | 1 |
|__________________________________________________________________________|____________|
Oral Mucosa | | 6 |
Gingival, Squamous Cell Carcinoma | | 2 |
|__________________________________________________________________________|____________|
Pancreas | + + + | 52 |
Sarcoma Stromal, Metastatic, Uterus | | 1 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + | 51 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 90
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
__________________________________________________________________________________________________________________________________
| 7| 7| 5| | |
DAY ON TEST | 2| 2| 8| | |
| 7| 9| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| | A |
550 | 8| 9| 9| | L |
NG/KG | 9| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Stomach, Forestomach | + + + | 51 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 51 |
|__________________________________________________________________________|____________|
Tooth | + + | 9 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + | 53 |
|__________________________________________________________________________|____________|
Heart | + + + | 51 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 52 |
Adenoma | | 1 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + | 52 |
Pheochromocytoma Malignant | | 1 |
Pheochromocytoma Benign | | 4 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 52 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + | 47 |
Adenoma | | 1 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + | 53 |
Pars Distalis, Adenoma | X | 13 |
Pars Distalis, Adenoma, Multiple | | 1 |
Pars Distalis, Carcinoma | X | 1 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + | 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 91
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
__________________________________________________________________________________________________________________________________
| 7| 7| 5| | |
DAY ON TEST | 2| 2| 8| | |
| 7| 9| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| | A |
550 | 8| 9| 9| | L |
NG/KG | 9| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
| | |
Bilateral, C-Cell, Adenoma | | 2 |
C-Cell, Adenoma | X | 10 |
C-Cell, Carcinoma | | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + | 52 |
|__________________________________________________________________________|____________|
Ovary | + + + | 52 |
Cystadenoma | | 1 |
|__________________________________________________________________________|____________|
Oviduct | | 3 |
|__________________________________________________________________________|____________|
Uterus | + + + | 52 |
Adenoma | | 1 |
Carcinoma | | 1 |
Polyp Stromal | X | 5 |
Sarcoma Stromal | X | 2 |
Schwannoma Malignant | | 1 |
Squamous Cell Papilloma | | 1 |
Cervix, Schwannoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + | 53 |
|__________________________________________________________________________|____________|
Lymph Node | + | 7 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 92
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
__________________________________________________________________________________________________________________________________
| 7| 7| 5| | |
DAY ON TEST | 2| 2| 8| | |
| 7| 9| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| | A |
550 | 8| 9| 9| | L |
NG/KG | 9| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lumbar, Sarcoma Stromal, Metastatic, | | |
Uterus | | 1 |
Mediastinal, Carcinoma, Metastatic, | | |
Thyroid Gland | | 1 |
Pancreatic, Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 51 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 51 |
|__________________________________________________________________________|____________|
Spleen | + + + | 52 |
Sarcoma Stromal, Metastatic, Uterus | | 1 |
|__________________________________________________________________________|____________|
Thymus | + + + | 49 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + | 52 |
Carcinoma | | 1 |
Fibroadenoma | X | 24 |
Fibroadenoma, Multiple | | 5 |
|__________________________________________________________________________|____________|
Skin | + + + | 53 |
Fibrous Histiocytoma | | 1 |
Squamous Cell Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + | 53 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 93
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
__________________________________________________________________________________________________________________________________
| 7| 7| 5| | |
DAY ON TEST | 2| 2| 8| | |
| 7| 9| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| | A |
550 | 8| 9| 9| | L |
NG/KG | 9| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
| | |
Brain | + + + | 53 |
Carcinoma, Metastatic, Pituitary | | |
Gland | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + | 51 |
Adenocarcinoma, Mucinous | | 1 |
Cystic Keratinizing Epithelioma | | 3 |
Cystic Keratinizing Epithelioma, | | |
Multiple | X | 8 |
Sarcoma, Metastatic, Kidney | | 1 |
Sarcoma Stromal, Metastatic, Uterus | | 1 |
Squamous Cell Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Nose | + + + | 53 |
|__________________________________________________________________________|____________|
Trachea | + + + | 52 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + | 52 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + | 52 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + | 52 |
Stromal Nephroma | | 1 |
Transitional Epithelium, Carcinoma | X | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + | 52 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + | 53 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 94
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
__________________________________________________________________________________________________________________________________
| 7| 7| 5| | |
DAY ON TEST | 2| 2| 8| | |
| 7| 9| 8| | |
_____________________________________________________________________________________________________________________ T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| | A |
550 | 8| 9| 9| | L |
NG/KG | 9| 6| 7| | |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS - cont | | |
| | |
Lymphoma Malignant | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 95
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 5| 1| 6| 7| 3| 7| 6| 6| 7| 6| 0| 6| 6| 7| 7| 6| 6| 5| 6| 5| 5|
DAY ON TEST | 2| 8| 6| 6| 3| 8| 0| 0| 0| 2| 5| 2| 2| 0| 7| 6| 3| 0| 2| 2| 0| 6| 1| 8| 8|
| 7| 1| 3| 3| 0| 8| 7| 4| 9| 7| 0| 1| 7| 7| 2| 0| 0| 0| 7| 1| 7| 2| 1| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1000 | 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7|
NG/KG | 1| 2| 3| 4| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cholangiocarcinoma | X X X |
Cholangiocarcinoma, Multiple | X X X X X X X |
Cholangioma | |
Hepatocellular Adenoma | X X X X |
Hepatocellular Adenoma, Multiple | X |
Hepatocholangioma | X X |
Hepatocholangioma, Multiple | X |
Leukemia Mononuclear | |
Lymphoma Malignant | X |
|__________________________________________________________________________|
Mesentery | + + + + + + + + + |
Lymphoma Malignant | X |
|__________________________________________________________________________|
Oral Mucosa | + + |
Gingival, Squamous Cell Carcinoma | X X |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + A + + + + + + + + + + +|
Lymphoma Malignant | X |
__________________________________________|__________________________________________________________________________|
Page 96
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 5| 1| 6| 7| 3| 7| 6| 6| 7| 6| 0| 6| 6| 7| 7| 6| 6| 5| 6| 5| 5|
DAY ON TEST | 2| 8| 6| 6| 3| 8| 0| 0| 0| 2| 5| 2| 2| 0| 7| 6| 3| 0| 2| 2| 0| 6| 1| 8| 8|
| 7| 1| 3| 3| 0| 8| 7| 4| 9| 7| 0| 1| 7| 7| 2| 0| 0| 0| 7| 1| 7| 2| 1| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1000 | 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7|
NG/KG | 1| 2| 3| 4| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Acinus, Carcinoma | X |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + M + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Tooth | + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Lymphoma Malignant | X |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + M + + + + + + + + + + +|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X |
Lymphoma Malignant | X |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + M + + M + + + + + + + +|
Adenoma | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M M M + + + M + + + M + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 97
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 5| 1| 6| 7| 3| 7| 6| 6| 7| 6| 0| 6| 6| 7| 7| 6| 6| 5| 6| 5| 5|
DAY ON TEST | 2| 8| 6| 6| 3| 8| 0| 0| 0| 2| 5| 2| 2| 0| 7| 6| 3| 0| 2| 2| 0| 6| 1| 8| 8|
| 7| 1| 3| 3| 0| 8| 7| 4| 9| 7| 0| 1| 7| 7| 2| 0| 0| 0| 7| 1| 7| 2| 1| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1000 | 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7|
NG/KG | 1| 2| 3| 4| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Squamous Cell Carcinoma, Metastatic, | |
Oral Mucosa | X |
Pars Distalis, Adenoma | X X X X |
|__________________________________________________________________________|
Thyroid Gland | + + + + A + + + + + + + + M + + + + + + A + + + +|
Adenoma | X |
C-Cell, Adenoma | X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + M + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Oviduct | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma, Multiple | |
Lymphoma Malignant | X |
Polyp Stromal | X X X |
|__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Lymph Node | + + + + |
Mediastinal, Lymphoma Malignant | X |
Pancreatic, Lymphoma Malignant | X |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 98
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 5| 1| 6| 7| 3| 7| 6| 6| 7| 6| 0| 6| 6| 7| 7| 6| 6| 5| 6| 5| 5|
DAY ON TEST | 2| 8| 6| 6| 3| 8| 0| 0| 0| 2| 5| 2| 2| 0| 7| 6| 3| 0| 2| 2| 0| 6| 1| 8| 8|
| 7| 1| 3| 3| 0| 8| 7| 4| 9| 7| 0| 1| 7| 7| 2| 0| 0| 0| 7| 1| 7| 2| 1| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1000 | 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7|
NG/KG | 1| 2| 3| 4| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymph Node, Mandibular | + + + + + + + + + + + + + M + + + + + + + + + + +|
Lymphoma Malignant | X |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X X |
|__________________________________________________________________________|
Spleen | + M + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Lymphoma Malignant | X |
|__________________________________________________________________________|
Thymus | + + + + M + + M + + + + + M + + + M + + + + + M +|
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
Fibroadenoma | X X X |
Lymphoma Malignant | X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | X |
Lymphoma Malignant | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 99
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 7| 6| 6| 6| 5| 1| 6| 7| 3| 7| 6| 6| 7| 6| 0| 6| 6| 7| 7| 6| 6| 5| 6| 5| 5|
DAY ON TEST | 2| 8| 6| 6| 3| 8| 0| 0| 0| 2| 5| 2| 2| 0| 7| 6| 3| 0| 2| 2| 0| 6| 1| 8| 8|
| 7| 1| 3| 3| 0| 8| 7| 4| 9| 7| 0| 1| 7| 7| 2| 0| 0| 0| 7| 1| 7| 2| 1| 8| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1000 | 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7|
NG/KG | 1| 2| 3| 4| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Lung | + + + + + + + + + + + + + M + + + + + + + + + + +|
Carcinoma, Metastatic, Adrenal Cortex| X |
Cystic Keratinizing Epithelioma | X X X |
Cystic Keratinizing Epithelioma, | |
Multiple | X X X X X X X X X X X X X X X|
Lymphoma Malignant | X |
Squamous Cell Carcinoma | X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma, Metastatic, | |
Oral Mucosa | X |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + M + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | + |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + M + + + + + + + + + + +|
Optic Nerve, Squamous Cell Carcinoma,| |
Metastatic, Oral Mucosa | X |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
Squamous Cell Carcinoma, Metastatic, | |
Oral Mucosa | X |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
Nephroblastoma | X |
Stromal Nephroma | |
|__________________________________________________________________________|
Ureter | + + + |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 100
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
__________________________________________|__________________________________________________________________________
| 7| 6| 6| 6| 5| 1| 6| 7| 3| 7| 6| 6| 7| 6| 0| 6| 6| 7| 7| 6| 6| 5| 6| 5| 5|
DAY ON TEST | 2| 8| 6| 6| 3| 8| 0| 0| 0| 2| 5| 2| 2| 0| 7| 6| 3| 0| 2| 2| 0| 6| 1| 8| 8|
| 7| 1| 3| 3| 0| 8| 7| 4| 9| 7| 0| 1| 7| 7| 2| 0| 0| 0| 7| 1| 7| 2| 1| 8| 8|
_____________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1000 | 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7|
NG/KG | 1| 2| 3| 4| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0|
_____________________________________________________________________________________________________________________
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | |
Lymphoma Malignant | X X |
__________________________________________|__________________________________________________________________________|
Page 101
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 7| 5| 7| 5| 6| 6| 2| 6| 5| 7| 7| 6| 6| 6| 2| 6| 5| 6| 6| 3| 5| 6| 4| 7| 6|
DAY ON TEST | 2| 4| 0| 2| 2| 9| 4| 8| 5| 2| 2| 0| 9| 0| 5| 0| 3| 1| 5| 9| 2| 4| 8| 2| 1|
| 7| 7| 0| 3| 1| 4| 3| 8| 5| 7| 7| 7| 4| 3| 8| 3| 1| 4| 0| 4| 5| 2| 4| 0| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1000 | 7| 7| 7| 7| 7| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4|
NG/KG | 1| 2| 3| 4| 5| 1| 2| 4| 5| 6| 7| 8| 9| 1| 4| 5| 6| 9| 0| 6| 7| 8| 0| 1| 3|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + M + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cholangiocarcinoma | X X X X |
Cholangiocarcinoma, Multiple | X X X X X X|
Cholangioma | X |
Hepatocellular Adenoma | X X |
Hepatocellular Adenoma, Multiple | |
Hepatocholangioma | |
Hepatocholangioma, Multiple | |
Leukemia Mononuclear | X |
Lymphoma Malignant | |
|__________________________________________________________________________|
Mesentery | + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Oral Mucosa | + + + + + + + + +|
Gingival, Squamous Cell Carcinoma | X X X X X|
|__________________________________________________________________________|
Pancreas | + + + A + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________|__________________________________________________________________________|
Page 102
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 7| 5| 7| 5| 6| 6| 2| 6| 5| 7| 7| 6| 6| 6| 2| 6| 5| 6| 6| 3| 5| 6| 4| 7| 6|
DAY ON TEST | 2| 4| 0| 2| 2| 9| 4| 8| 5| 2| 2| 0| 9| 0| 5| 0| 3| 1| 5| 9| 2| 4| 8| 2| 1|
| 7| 7| 0| 3| 1| 4| 3| 8| 5| 7| 7| 7| 4| 3| 8| 3| 1| 4| 0| 4| 5| 2| 4| 0| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1000 | 7| 7| 7| 7| 7| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4|
NG/KG | 1| 2| 3| 4| 5| 1| 2| 4| 5| 6| 7| 8| 9| 1| 4| 5| 6| 9| 0| 6| 7| 8| 0| 1| 3|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Acinus, Carcinoma | |
|__________________________________________________________________________|
Salivary Glands | + + + M + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Tooth | + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Aorta, Lymphoma Malignant | |
|__________________________________________________________________________|
Heart | + + + M + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
Carcinoma | X |
Lymphoma Malignant | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
|__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + + M + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 103
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 7| 5| 7| 5| 6| 6| 2| 6| 5| 7| 7| 6| 6| 6| 2| 6| 5| 6| 6| 3| 5| 6| 4| 7| 6|
DAY ON TEST | 2| 4| 0| 2| 2| 9| 4| 8| 5| 2| 2| 0| 9| 0| 5| 0| 3| 1| 5| 9| 2| 4| 8| 2| 1|
| 7| 7| 0| 3| 1| 4| 3| 8| 5| 7| 7| 7| 4| 3| 8| 3| 1| 4| 0| 4| 5| 2| 4| 0| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1000 | 7| 7| 7| 7| 7| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4|
NG/KG | 1| 2| 3| 4| 5| 1| 2| 4| 5| 6| 7| 8| 9| 1| 4| 5| 6| 9| 0| 6| 7| 8| 0| 1| 3|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Squamous Cell Carcinoma, Metastatic, | |
Oral Mucosa | |
Pars Distalis, Adenoma | X X |
|__________________________________________________________________________|
Thyroid Gland | + + + M + + A + + + + + + + + + + + + + + + + + +|
Adenoma | |
C-Cell, Adenoma | X X X X X X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Oviduct | + |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma, Multiple | X |
Lymphoma Malignant | |
Polyp Stromal | X |
|__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Lymph Node | + + + + + + + +|
Mediastinal, Lymphoma Malignant | |
Pancreatic, Lymphoma Malignant | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 104
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 7| 5| 7| 5| 6| 6| 2| 6| 5| 7| 7| 6| 6| 6| 2| 6| 5| 6| 6| 3| 5| 6| 4| 7| 6|
DAY ON TEST | 2| 4| 0| 2| 2| 9| 4| 8| 5| 2| 2| 0| 9| 0| 5| 0| 3| 1| 5| 9| 2| 4| 8| 2| 1|
| 7| 7| 0| 3| 1| 4| 3| 8| 5| 7| 7| 7| 4| 3| 8| 3| 1| 4| 0| 4| 5| 2| 4| 0| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1000 | 7| 7| 7| 7| 7| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4|
NG/KG | 1| 2| 3| 4| 5| 1| 2| 4| 5| 6| 7| 8| 9| 1| 4| 5| 6| 9| 0| 6| 7| 8| 0| 1| 3|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lymph Node, Mandibular | + + + M + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Lymphoma Malignant | |
|__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + + + M + + + + + + + +|
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | |
Fibroadenoma | X X X X X X X X|
Lymphoma Malignant | |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | |
Lymphoma Malignant | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 105
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 7| 5| 7| 5| 6| 6| 2| 6| 5| 7| 7| 6| 6| 6| 2| 6| 5| 6| 6| 3| 5| 6| 4| 7| 6|
DAY ON TEST | 2| 4| 0| 2| 2| 9| 4| 8| 5| 2| 2| 0| 9| 0| 5| 0| 3| 1| 5| 9| 2| 4| 8| 2| 1|
| 7| 7| 0| 3| 1| 4| 3| 8| 5| 7| 7| 7| 4| 3| 8| 3| 1| 4| 0| 4| 5| 2| 4| 0| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1000 | 7| 7| 7| 7| 7| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4|
NG/KG | 1| 2| 3| 4| 5| 1| 2| 4| 5| 6| 7| 8| 9| 1| 4| 5| 6| 9| 0| 6| 7| 8| 0| 1| 3|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Lung | + + + M + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Adrenal Cortex| |
Cystic Keratinizing Epithelioma | X X |
Cystic Keratinizing Epithelioma, | |
Multiple | X X X X X X X X X X X X X X|
Lymphoma Malignant | |
Squamous Cell Carcinoma | X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma, Metastatic, | |
Oral Mucosa | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | + |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Optic Nerve, Squamous Cell Carcinoma,| |
Metastatic, Oral Mucosa | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma, Metastatic, | |
Oral Mucosa | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
Nephroblastoma | X |
Stromal Nephroma | X |
|__________________________________________________________________________|
Ureter | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 106
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
__________________________________________|__________________________________________________________________________
| 7| 5| 7| 5| 6| 6| 2| 6| 5| 7| 7| 6| 6| 6| 2| 6| 5| 6| 6| 3| 5| 6| 4| 7| 6|
DAY ON TEST | 2| 4| 0| 2| 2| 9| 4| 8| 5| 2| 2| 0| 9| 0| 5| 0| 3| 1| 5| 9| 2| 4| 8| 2| 1|
| 7| 7| 0| 3| 1| 4| 3| 8| 5| 7| 7| 7| 4| 3| 8| 3| 1| 4| 0| 4| 5| 2| 4| 0| 8|
_____________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|
1000 | 7| 7| 7| 7| 7| 0| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4|
NG/KG | 1| 2| 3| 4| 5| 1| 2| 4| 5| 6| 7| 8| 9| 1| 4| 5| 6| 9| 0| 6| 7| 8| 0| 1| 3|
_____________________________________________________________________________________________________________________
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Leukemia Mononuclear | X |
Lymphoma Malignant | |
__________________________________________|__________________________________________________________________________|
Page 107
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
__________________________________________________________________________________________________________________________________
| 6| 2| 5| | |
DAY ON TEST | 0| 4| 7| | |
| 3| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| | A |
1000 | 4| 4| 4| | L |
NG/KG | 4| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + | 52 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + | 53 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + | 53 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + | 53 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + | 53 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + | 53 |
|__________________________________________________________________________|____________|
Liver | + + + | 53 |
Cholangiocarcinoma | | 7 |
Cholangiocarcinoma, Multiple | X X | 15 |
Cholangioma | | 1 |
Hepatocellular Adenoma | | 6 |
Hepatocellular Adenoma, Multiple | | 1 |
Hepatocholangioma | | 2 |
Hepatocholangioma, Multiple | | 1 |
Leukemia Mononuclear | | 1 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Mesentery | | 11 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Oral Mucosa | | 11 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 108
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
__________________________________________________________________________________________________________________________________
| 6| 2| 5| | |
DAY ON TEST | 0| 4| 7| | |
| 3| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| | A |
1000 | 4| 4| 4| | L |
NG/KG | 4| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Gingival, Squamous Cell Carcinoma | | 7 |
|__________________________________________________________________________|____________|
Pancreas | + + + | 51 |
Lymphoma Malignant | | 1 |
Acinus, Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + | 51 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 53 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + | 53 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Tooth | + | 19 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + | 53 |
Aorta, Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Heart | + + + | 51 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 53 |
Adenoma | | 2 |
Carcinoma | | 2 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 109
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
__________________________________________________________________________________________________________________________________
| 6| 2| 5| | |
DAY ON TEST | 0| 4| 7| | |
| 3| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| | A |
1000 | 4| 4| 4| | L |
NG/KG | 4| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
| | |
Adrenal Medulla | + + + | 53 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + | 51 |
Adenoma | | 1 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + | 46 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + | 53 |
Squamous Cell Carcinoma, Metastatic, | | |
Oral Mucosa | | 1 |
Pars Distalis, Adenoma | | 6 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + | 48 |
Adenoma | | 1 |
C-Cell, Adenoma | X | 9 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + | 51 |
|__________________________________________________________________________|____________|
Ovary | + + + | 53 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Oviduct | | 1 |
|__________________________________________________________________________|____________|
Uterus | + + + | 53 |
Adenoma, Multiple | | 1 |
Lymphoma Malignant | | 1 |
Polyp Stromal | | 4 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 110
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
__________________________________________________________________________________________________________________________________
| 6| 2| 5| | |
DAY ON TEST | 0| 4| 7| | |
| 3| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| | A |
1000 | 4| 4| 4| | L |
NG/KG | 4| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + | 53 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Lymph Node | | 12 |
Mediastinal, Lymphoma Malignant | | 1 |
Pancreatic, Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + | 51 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + | 53 |
Lymphoma Malignant | | 2 |
|__________________________________________________________________________|____________|
Spleen | + + + | 52 |
Leukemia Mononuclear | | 1 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Thymus | M M + | 44 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + | 53 |
Carcinoma | | 1 |
Fibroadenoma | | 11 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 111
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
__________________________________________________________________________________________________________________________________
| 6| 2| 5| | |
DAY ON TEST | 0| 4| 7| | |
| 3| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| | A |
1000 | 4| 4| 4| | L |
NG/KG | 4| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
| | |
Skin | + + + | 53 |
Keratoacanthoma | | 1 |
Lymphoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + | 53 |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + | 53 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + | 51 |
Carcinoma, Metastatic, Adrenal Cortex| | 1 |
Cystic Keratinizing Epithelioma | | 5 |
Cystic Keratinizing Epithelioma, | | |
Multiple | X | 30 |
Lymphoma Malignant | | 1 |
Squamous Cell Carcinoma | | 2 |
|__________________________________________________________________________|____________|
Nose | + + + | 53 |
Squamous Cell Carcinoma, Metastatic, | | |
Oral Mucosa | | 1 |
|__________________________________________________________________________|____________|
Trachea | + + + | 52 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 112
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
__________________________________________________________________________________________________________________________________
| 6| 2| 5| | |
DAY ON TEST | 0| 4| 7| | |
| 3| 4| 4| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| | O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| | A |
1000 | 4| 4| 4| | L |
NG/KG | 4| 6| 7| | |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
| | |
Ear | | 2 |
|__________________________________________________________________________|____________|
Eye | + + + | 52 |
Optic Nerve, Squamous Cell Carcinoma,| | |
Metastatic, Oral Mucosa | | 1 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + | 52 |
Squamous Cell Carcinoma, Metastatic, | | |
Oral Mucosa | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + | 53 |
Lymphoma Malignant | | 1 |
Nephroblastoma | | 2 |
Stromal Nephroma | | 1 |
|__________________________________________________________________________|____________|
Ureter | | 3 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + | 53 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + | 53 |
Leukemia Mononuclear | | 1 |
Lymphoma Malignant | | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 113
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 7| 2| 5| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 6| 4|
DAY ON TEST | 2| 8| 0| 2| 2| 2| 2| 7| 2| 5| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 5| 9| 2| 3| 1|
| 7| 4| 2| 7| 7| 8| 7| 1| 7| 4| 7| 8| 8| 8| 8| 9| 7| 8| 9| 9| 9| 2| 8| 7| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1000 NG/ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
KG/STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cholangiocarcinoma | X |
|__________________________________________________________________________|
Oral Mucosa | + + + + |
Gingival, Squamous Cell Carcinoma | X |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + A|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + M|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tooth | + + + + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 114
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 7| 2| 5| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 6| 4|
DAY ON TEST | 2| 8| 0| 2| 2| 2| 2| 7| 2| 5| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 5| 9| 2| 3| 1|
| 7| 4| 2| 7| 7| 8| 7| 1| 7| 4| 7| 8| 8| 8| 8| 9| 7| 8| 9| 9| 9| 2| 8| 7| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1000 NG/ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
KG/STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X |
Carcinoma | X |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pheochromocytoma Benign | |
Bilateral, Pheochromocytoma Benign | X |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | |
|__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + M + + + + M + + M + + + + + + M|
Adenoma | |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
Pars Distalis, Adenoma | X X X X X X X X X |
|__________________________________________________________________________|
Thyroid Gland | + A + + + + + + + + + + + + + + + + + + + + + + M|
Bilateral, C-Cell, Adenoma | X X X X |
C-Cell, Adenoma | X X X X X X X |
C-Cell, Carcinoma | X |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granulosa-Theca Tumor Benign | X |
|__________________________________________________________________________|
Oviduct | + |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
__________________________________________|__________________________________________________________________________|
Page 115
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 7| 2| 5| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 6| 4|
DAY ON TEST | 2| 8| 0| 2| 2| 2| 2| 7| 2| 5| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 5| 9| 2| 3| 1|
| 7| 4| 2| 7| 7| 8| 7| 1| 7| 4| 7| 8| 8| 8| 8| 9| 7| 8| 9| 9| 9| 2| 8| 7| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1000 NG/ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
KG/STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Polyp Stromal | X X |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | |
Lymphoma Malignant | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + + + M M + + + + + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma | X |
Fibroadenoma | X X X X X X X X X |
Fibroadenoma, Multiple | X X X X X X X X |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Keratoacanthoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Osteosarcoma | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Astrocytoma Malignant | X |
__________________________________________|__________________________________________________________________________|
Page 116
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
_____________________________________________________________________________________________________________________
| 7| 2| 5| 7| 7| 7| 7| 6| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 5| 7| 6| 4|
DAY ON TEST | 2| 8| 0| 2| 2| 2| 2| 7| 2| 5| 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| 5| 9| 2| 3| 1|
| 7| 4| 2| 7| 7| 8| 7| 1| 7| 4| 7| 8| 8| 8| 8| 9| 7| 8| 9| 9| 9| 2| 8| 7| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
1000 NG/ | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
KG/STOP | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Carcinoma, Metastatic, Mammary Gland | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | + |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lacrimal Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | |
__________________________________________|__________________________________________________________________________|
Page 117
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
__________________________________________________________________________________________________________________________________
| 7| 4| 3| 3| 7| 7| 6| 7| 5| 6| 7| 6| 7| 5| 7| 7| 3| 6| 5| 5| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 5| 2| 3| 2| 2| 1| 2| 5| 2| 2| 6| 2| 7| 2| 2| 2| 1| 3| 9| 2| 2| 1| 2| 2| |
| 7| 4| 0| 7| 8| 9| 8| 7| 4| 5| 8| 0| 9| 4| 8| 7| 8| 8| 7| 3| 9| 7| 1| 8| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| A |
1000 NG/ | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
KG/STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cholangiocarcinoma | X | 2 |
|__________________________________________________________________________|____________|
Oral Mucosa | + + | 6 |
Gingival, Squamous Cell Carcinoma | X | 2 |
|__________________________________________________________________________|____________|
Pancreas | + + A + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Tooth | + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 118
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
__________________________________________________________________________________________________________________________________
| 7| 4| 3| 3| 7| 7| 6| 7| 5| 6| 7| 6| 7| 5| 7| 7| 3| 6| 5| 5| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 5| 2| 3| 2| 2| 1| 2| 5| 2| 2| 6| 2| 7| 2| 2| 2| 1| 3| 9| 2| 2| 1| 2| 2| |
| 7| 4| 0| 7| 8| 9| 8| 7| 4| 5| 8| 0| 9| 4| 8| 7| 8| 8| 7| 3| 9| 7| 1| 8| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| A |
1000 NG/ | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
KG/STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | | 2 |
Carcinoma | | 1 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pheochromocytoma Benign | X X | 2 |
Bilateral, Pheochromocytoma Benign | | 1 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | X| 1 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + + + + + + + + + + + + + + + + +| 44 |
Adenoma | X | 1 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| 48 |
Pars Distalis, Adenoma | X X X X X X X X | 17 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + A + + + + + + + + + + + + + + + + + + + + + +| 47 |
Bilateral, C-Cell, Adenoma | X | 5 |
C-Cell, Adenoma | X X X X | 11 |
C-Cell, Carcinoma | | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 119
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
__________________________________________________________________________________________________________________________________
| 7| 4| 3| 3| 7| 7| 6| 7| 5| 6| 7| 6| 7| 5| 7| 7| 3| 6| 5| 5| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 5| 2| 3| 2| 2| 1| 2| 5| 2| 2| 6| 2| 7| 2| 2| 2| 1| 3| 9| 2| 2| 1| 2| 2| |
| 7| 4| 0| 7| 8| 9| 8| 7| 4| 5| 8| 0| 9| 4| 8| 7| 8| 8| 7| 3| 9| 7| 1| 8| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| A |
1000 NG/ | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
KG/STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Clitoral Gland | + M + M + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granulosa-Theca Tumor Benign | | 1 |
|__________________________________________________________________________|____________|
Oviduct | + | 2 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Adenoma | | 1 |
Polyp Stromal | X X X| 5 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node | + + | 2 |
Lymphoma Malignant | X | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Thymus | + M + M + + + + + + + + + + + + + + M + + + + + +| 43 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma | X X X | 4 |
Fibroadenoma | X X X X X X | 15 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 120
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
__________________________________________________________________________________________________________________________________
| 7| 4| 3| 3| 7| 7| 6| 7| 5| 6| 7| 6| 7| 5| 7| 7| 3| 6| 5| 5| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 5| 2| 3| 2| 2| 1| 2| 5| 2| 2| 6| 2| 7| 2| 2| 2| 1| 3| 9| 2| 2| 1| 2| 2| |
| 7| 4| 0| 7| 8| 9| 8| 7| 4| 5| 8| 0| 9| 4| 8| 7| 8| 8| 7| 3| 9| 7| 1| 8| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| A |
1000 NG/ | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
KG/STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
| | |
Fibroadenoma, Multiple | X X X X X | 13 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Keratoacanthoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Osteosarcoma | X | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Astrocytoma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Carcinoma, Metastatic, Mammary Gland | X | 1 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | | 1 |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 121
NTP Experiment-Test: 96007-01 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/01/03
Route: GAVAGE Time: 11:42:15
__________________________________________________________________________________________________________________________________
| 7| 4| 3| 3| 7| 7| 6| 7| 5| 6| 7| 6| 7| 5| 7| 7| 3| 6| 5| 5| 7| 7| 6| 7| 7| |
DAY ON TEST | 2| 5| 2| 3| 2| 2| 1| 2| 5| 2| 2| 6| 2| 7| 2| 2| 2| 1| 3| 9| 2| 2| 1| 2| 2| |
| 7| 4| 0| 7| 8| 9| 8| 7| 4| 5| 8| 0| 9| 4| 8| 7| 8| 8| 7| 3| 9| 7| 1| 8| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SPRAGUE-DAWLEY RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| A |
1000 NG/ | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
KG/STOP | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
| | |
Lacrimal Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lymphoma Malignant | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 122
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