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TDMS Study 96007-01 Pathology Tables

NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03
Route: GAVAGE                                                                                                     Time: 11:43:51

                                                         FINAL #3/RATS




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  57465-28-8

       Lock Date:  01/09/01

       Cage Range:  All

       Reasons For Removal:    25022 Accidently Killed                 25018 Dosing Accident
                               25019 Moribund Sacrifice                25020 Natural Death
                               25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 001    0 NG/KG
                               Include 003    30 NG/KG
                               Include 004    100     NG/KG
                               Include 005    175     NG/KG
                               Include 006    300     NG/KG
                               Include 007    550     NG/KG
                               Include 008    1000    NG/KG
                               Include 009    1000 NG/KG/STOP



























                                                              Page   1


NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 5| 4| 7| 6| 5| 5| 7| 4| 5| 7| 6| 5| 7| 7| 6| 6| 6| 7| 1| 7| 5| 2| 2|             
                             DAY ON TEST   | 9| 0| 3| 9| 2| 0| 7| 5| 2| 9| 1| 2| 6| 8| 2| 2| 7| 6| 4| 2| 7| 2| 9| 2| 0|             
                                           | 1| 9| 1| 6| 7| 0| 4| 4| 9| 6| 9| 7| 0| 3| 7| 7| 1| 0| 4| 7| 6| 7| 2| 2| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG/KG                                | 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 6| 6|             
                                           | 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 5| 7| 8| 9| 0| 1| 2| 3| 7| 8| 9| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Inflammation             |                                           1                              |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                        2                                 |             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Serosa, Inflammation, Chronic Active | 3                                                                        |             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                           1           1                  |             
      Basophilic Focus                     |                                           X                              |             
      Basophilic Focus, Multiple           |                                                       X                  |             
      Clear Cell Focus                     |                                                          X               |             
      Clear Cell Focus, Multiple           |                                                                          |             
      Eosinophilic Focus                   |                               X                                          |             
      Eosinophilic Focus, Multiple         |             X           X                 X                              |             
      Fatty Change, Diffuse                |                                  1           1        1                  |             
      Fatty Change, Focal                  |                         2     1                                          |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation                         | 1        1  1     1  1  1  1  1  1        1  1  1  1  1  2  2  1         |             
      Mixed Cell Focus                     |    X                                                                     |             
      Mixed Cell Focus, Multiple           |             X           X                 X  X  X        X     X         |             
      Necrosis                             |                      2                                      3            |             
      Pigmentation                         |                            1                                             |             
      Bile Duct, Cyst                      |             1                                                            |             
      Bile Duct, Fibrosis                  | 1                                                                        |             
      Bile Duct, Hyperplasia               |       1                    1                                             |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 5| 4| 7| 6| 5| 5| 7| 4| 5| 7| 6| 5| 7| 7| 6| 6| 6| 7| 1| 7| 5| 2| 2|             
                             DAY ON TEST   | 9| 0| 3| 9| 2| 0| 7| 5| 2| 9| 1| 2| 6| 8| 2| 2| 7| 6| 4| 2| 7| 2| 9| 2| 0|             
                                           | 1| 9| 1| 6| 7| 0| 4| 4| 9| 6| 9| 7| 0| 3| 7| 7| 1| 0| 4| 7| 6| 7| 2| 2| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG/KG                                | 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 6| 6|             
                                           | 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 5| 7| 8| 9| 0| 1| 2| 3| 7| 8| 9| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Hepatocyte, Degeneration             |                            2                                             |             
                                           |__________________________________________________________________________|             
   Mesentery                               | +                                                                        |             
      Inflammation, Chronic Active         | 4                                                                        |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
      Gingival, Hyperplasia, Squamous      |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Inflammation, Chronic Active         | 3     1     1           1                                                |             
      Acinus, Atrophy                      |             2           2                 2                              |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                2         |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                       3                  |             
      Hyperplasia, Squamous                | 1                                2                                       |             
      Inflammation, Acute                  |                                                                          |             
      Mineralization                       |                                                                         2|             
      Ulcer                                |                   2              2                    2                  |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                2                                                         |             
      Mineralization                       |                2                                                         |             
                                           |__________________________________________________________________________|             
   Tooth                                   |                                  +        +                    +         |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic Active                  |                                  3                                       |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Suppurative                     |                                           1                    1         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |                2                       1                          1      |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 5| 4| 7| 6| 5| 5| 7| 4| 5| 7| 6| 5| 7| 7| 6| 6| 6| 7| 1| 7| 5| 2| 2|             
                             DAY ON TEST   | 9| 0| 3| 9| 2| 0| 7| 5| 2| 9| 1| 2| 6| 8| 2| 2| 7| 6| 4| 2| 7| 2| 9| 2| 0|             
                                           | 1| 9| 1| 6| 7| 0| 4| 4| 9| 6| 9| 7| 0| 3| 7| 7| 1| 0| 4| 7| 6| 7| 2| 2| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG/KG                                | 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 6| 6|             
                                           | 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 5| 7| 8| 9| 0| 1| 2| 3| 7| 8| 9| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
      Cardiomyopathy                       | 1                                      1                 1        1     1|             
      Degeneration                         |                                                                          |             
      Mineralization                       |                2                                                         |             
      Thrombosis                           |                                        2                                 |             
      Epicardium, Inflammation, Suppurative|                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                   1  1              1     2                              |             
      Atrophy                              |                                                                          |             
      Degeneration, Cystic                 |                            2  2        2  2                       3      |             
      Hyperplasia                          |    2        2        1     1  3     1  1  2     2  2     2     2  2      |             
      Hypertrophy                          | 2  2  2  3  1     2  1  2        2  2     2  3  3  1  2  2     1         |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                2                                                         |             
      Vacuolization Cytoplasmic            |       1  2  1                    1                                       |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          1                    2  1           2                    3      |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    3                 2  2        2        2  3  2     4        2         |             
      Pars Distalis, Hyperplasia           |       3                       2     2              2                     |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      C-Cell, Hyperplasia                  |    1                                         2  3                        |             
      Follicular Cell, Hypertrophy         |                                                                1     1  1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 5| 4| 7| 6| 5| 5| 7| 4| 5| 7| 6| 5| 7| 7| 6| 6| 6| 7| 1| 7| 5| 2| 2|             
                             DAY ON TEST   | 9| 0| 3| 9| 2| 0| 7| 5| 2| 9| 1| 2| 6| 8| 2| 2| 7| 6| 4| 2| 7| 2| 9| 2| 0|             
                                           | 1| 9| 1| 6| 7| 0| 4| 4| 9| 6| 9| 7| 0| 3| 7| 7| 1| 0| 4| 7| 6| 7| 2| 2| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG/KG                                | 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 6| 6|             
                                           | 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 5| 7| 8| 9| 0| 1| 2| 3| 7| 8| 9| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |       1  1        2     2                    2     2                 2   |             
      Duct, Cyst                           | 1        1     1  2     2     2        2     2  3  2  3     1     2  1   |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4  4  4  4  4  4  4  4     4  4  4  4  4  4  4  4  4  4     4  4  4   |             
      Cyst                                 |             2  2        2        2     2  2  2                           |             
                                           |__________________________________________________________________________|             
   Oviduct                                 |    +                                                                     |             
      Inflammation, Suppurative            |    2                                                                     |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Granulomatous          |                                           2                              |             
      Inflammation, Suppurative            | 2  1     3        1  3              2           1        2        3      |             
      Metaplasia, Squamous                 | 3     2        1  1  1  1     2           1        1  2  3        3      |             
      Endometrium, Hyperplasia, Cystic     |    2     2  2           1        1  3     2  3     1     1     2         |             
      Epithelium, Hyperplasia              |                                                                          |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 4  4  4  4  3  3  3  4  2  4  3  4  4  4  4  3  3  4  2  3  4  3  4  3  2|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                                             +            |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                    2                     |             
      Hyperplasia, Plasma Cell             | 2        2           2        3  2           3     2                 2   |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Histiocytic             |                   2                                                  1   |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 5| 4| 7| 6| 5| 5| 7| 4| 5| 7| 6| 5| 7| 7| 6| 6| 6| 7| 1| 7| 5| 2| 2|             
                             DAY ON TEST   | 9| 0| 3| 9| 2| 0| 7| 5| 2| 9| 1| 2| 6| 8| 2| 2| 7| 6| 4| 2| 7| 2| 9| 2| 0|             
                                           | 1| 9| 1| 6| 7| 0| 4| 4| 9| 6| 9| 7| 0| 3| 7| 7| 1| 0| 4| 7| 6| 7| 2| 2| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG/KG                                | 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 6| 6|             
                                           | 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 5| 7| 8| 9| 0| 1| 2| 3| 7| 8| 9| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Hematopoietic Cell Proliferation     |    2  3  3     2  1  2     3  2  2  1     2  1  1  2     2     1  1  1   |             
      Pigmentation                         | 2  1  1  1  2  1  1  1  2     1  1  1  1  1  2  2  1  2  1     1  1  1  2|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Atrophy                              | 4     3  2  3  4  2  3  2  2  3  3  3  3  2        2  2        2  3     2|             
      Hemorrhage                           |                                                                      3   |             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    2                          1                    1     2               |             
      Hyperplasia                          |    1  1     2  1     2  1  2     2  2        1  1        1        1  1  1|             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Granulomatous          |    2                                                                     |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst, Squamous                       |                                        2                                 |             
      Dermis, Inflammation, Focal          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 2                                                                        |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         | +                                                                        |             
      Inflammation, Chronic Active         | 3                                                                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |                                                                         1|             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                       +                 +|             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                       +                 +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 5| 4| 7| 6| 5| 5| 7| 4| 5| 7| 6| 5| 7| 7| 6| 6| 6| 7| 1| 7| 5| 2| 2|             
                             DAY ON TEST   | 9| 0| 3| 9| 2| 0| 7| 5| 2| 9| 1| 2| 6| 8| 2| 2| 7| 6| 4| 2| 7| 2| 9| 2| 0|             
                                           | 1| 9| 1| 6| 7| 0| 4| 4| 9| 6| 9| 7| 0| 3| 7| 7| 1| 0| 4| 7| 6| 7| 2| 2| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG/KG                                | 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 6| 6|             
                                           | 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 5| 7| 8| 9| 0| 1| 2| 3| 7| 8| 9| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                      3   |             
      Infiltration Cellular, Histiocyte    | 2  2  2  2  2  2  1  2        2  2  2  2  2     1  2     2     2  1  2  1|             
      Inflammation, Chronic Active         |    2        1                                                            |             
      Inflammation, Granulomatous          |                         2                                                |             
      Metaplasia, Squamous                 |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |    1           1                 1                       1     1         |             
      Serosa, Inflammation, Suppurative    |                                                                   2      |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasopharyngeal Duct, Inflammation,   |                                                                          |             
           Suppurative                     | 4                                                                        |             
      Olfactory Epithelium, Inflammation,  |                                                                          |             
           Suppurative                     | 3                                                                        |             
      Respiratory Epithelium, Hyperplasia  | 2                                                                        |             
      Respiratory Epithelium, Metaplasia   | 4                                                                        |             
      Turbinate, Inflammation, Suppurative |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Peritracheal Tissue, Inflammation    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Casts Protein                        |                                           1                              |             
      Inflammation, Chronic Active         |                   3                                            1         |             
      Mineralization                       |          1  1  2  1  1  1  1  1  1     1     1     1  1  1     1  1     1|             
      Nephropathy                          | 4  2  1     1  1              1  2     1  1  2  1     2  1  1        1  1|             
      Pelvis, Dilatation                   |                   2                    2                                 |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 5| 4| 7| 6| 5| 5| 7| 4| 5| 7| 6| 5| 7| 7| 6| 6| 6| 7| 1| 7| 5| 2| 2|             
                             DAY ON TEST   | 9| 0| 3| 9| 2| 0| 7| 5| 2| 9| 1| 2| 6| 8| 2| 2| 7| 6| 4| 2| 7| 2| 9| 2| 0|             
                                           | 1| 9| 1| 6| 7| 0| 4| 4| 9| 6| 9| 7| 0| 3| 7| 7| 1| 0| 4| 7| 6| 7| 2| 2| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG/KG                                | 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 6| 6|             
                                           | 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 5| 7| 8| 9| 0| 1| 2| 3| 7| 8| 9| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
      Pelvis, Inflammation, Suppurative    |                      1                                                   |             
      Transitional Epithelium, Hyperplasia |                   2  3           2                                       |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1  1              2                                                      |             
      Transitional Epithelium, Hyperplasia |                   2                                                      |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 7| 6| 7| 3| 3| 7| 2| 3| 6| 6| 7| 6| 7| 6| 3| 5| 6| 6| 4| 7| 7| 7|             
                             DAY ON TEST   | 4| 2| 5| 2| 5| 2| 4| 5| 2| 0| 0| 0| 0| 2| 6| 2| 1| 2| 4| 1| 8| 0| 2| 2| 0|             
                                           | 6| 9| 0| 7| 2| 7| 3| 4| 9| 1| 9| 3| 7| 9| 0| 9| 8| 1| 1| 1| 8| 5| 7| 7| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Muscularis, Inflammation             |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                         X                                            X   |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Serosa, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                      2   |             
      Basophilic Focus                     |                                              X                           |             
      Basophilic Focus, Multiple           |    X                                                  X     X           X|             
      Clear Cell Focus                     |                                                                          |             
      Clear Cell Focus, Multiple           |                                        X                                 |             
      Eosinophilic Focus                   | X        X  X                                                  X     X   |             
      Eosinophilic Focus, Multiple         |                                                 X           X            |             
      Fatty Change, Diffuse                |                   1                                                      |             
      Fatty Change, Focal                  |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                 X                        |             
      Inflammation                         |    1     1  1  1        1  1     1     1  1  1     1  1  1  1  1  1  1  1|             
      Mixed Cell Focus                     |             X                                            X           X   |             
      Mixed Cell Focus, Multiple           |    X  X        X        X              X        X     X     X     X      |             
      Necrosis                             |             2                                                  2         |             
      Pigmentation                         |                                                                          |             
      Bile Duct, Cyst                      |                         2                                            2   |             
      Bile Duct, Fibrosis                  |    1                    1              1                                 |             
      Bile Duct, Hyperplasia               |                         2                                                |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 7| 6| 7| 3| 3| 7| 2| 3| 6| 6| 7| 6| 7| 6| 3| 5| 6| 6| 4| 7| 7| 7|             
                             DAY ON TEST   | 4| 2| 5| 2| 5| 2| 4| 5| 2| 0| 0| 0| 0| 2| 6| 2| 1| 2| 4| 1| 8| 0| 2| 2| 0|             
                                           | 6| 9| 0| 7| 2| 7| 3| 4| 9| 1| 9| 3| 7| 9| 0| 9| 8| 1| 1| 1| 8| 5| 7| 7| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Hepatocyte, Degeneration             |                      3                                                  2|             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |          +                                                               |             
      Gingival, Hyperplasia, Squamous      |          2                                                               |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |    2                                                                     |             
      Acinus, Atrophy                      |    2                                                                    2|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Hyperplasia, Squamous                |                                                                         2|             
      Inflammation, Acute                  |                                                                         1|             
      Mineralization                       |                                                                          |             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Mineralization                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   |       +  +     +                       +              +  +     +  +     +|             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                                   2      |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Suppurative                     |       1  2     1                       1              2  1     1        2|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 7| 6| 7| 3| 3| 7| 2| 3| 6| 6| 7| 6| 7| 6| 3| 5| 6| 6| 4| 7| 7| 7|             
                             DAY ON TEST   | 4| 2| 5| 2| 5| 2| 4| 5| 2| 0| 0| 0| 0| 2| 6| 2| 1| 2| 4| 1| 8| 0| 2| 2| 0|             
                                           | 6| 9| 0| 7| 2| 7| 3| 4| 9| 1| 9| 3| 7| 9| 0| 9| 8| 1| 1| 1| 8| 5| 7| 7| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
      Cardiomyopathy                       |                                              1  1  1        1            |             
      Degeneration                         |                                                                          |             
      Mineralization                       |                                                                          |             
      Thrombosis                           |                                                                          |             
      Epicardium, Inflammation, Suppurative|                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                  2  2  2     1  1     1              2   |             
      Atrophy                              |                                                                   1      |             
      Degeneration, Cystic                 |          2  2  2                    2                             2     2|             
      Hyperplasia                          |       3  3        2           2  2  1           1                 2  2   |             
      Hypertrophy                          |    2  1  3  3  2        2           1  2     2  1        1  2  1  2  3  3|             
      Mineralization                       |                                                       2                  |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                      1   |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                         1        1                          1            |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                2                                                         |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +     +  +  +  +     +  +  M  +  +  +  +  +  +  M  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +|             
      Angiectasis                          | 1     1                          2                                1  2   |             
      Pars Distalis, Hyperplasia           | 4     1  3  2  1        3        2     2        2        2  1           1|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |          1  3           1        2     2     1        1  3               |             
      Follicular Cell, Hypertrophy         |                   2  1        3           1        1                 1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 7| 6| 7| 3| 3| 7| 2| 3| 6| 6| 7| 6| 7| 6| 3| 5| 6| 6| 4| 7| 7| 7|             
                             DAY ON TEST   | 4| 2| 5| 2| 5| 2| 4| 5| 2| 0| 0| 0| 0| 2| 6| 2| 1| 2| 4| 1| 8| 0| 2| 2| 0|             
                                           | 6| 9| 0| 7| 2| 7| 3| 4| 9| 1| 9| 3| 7| 9| 0| 9| 8| 1| 1| 1| 8| 5| 7| 7| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 3  2  1     1  2  1  1  1     1     1  2  2  1  1     1  2     1  1  1  1|             
      Duct, Cyst                           |          2        1     2           2  3  3  2  3        3  1  1  2  1  2|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4  4  4  4  4        4        4  4     4  4  4  4  4  4  4  4  4  4  3|             
      Cyst                                 |          3                          2        2                          1|             
                                           |__________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Granulomatous          |                                                                          |             
      Inflammation, Suppurative            |             1                       1                                2   |             
      Metaplasia, Squamous                 | 2  1  1  2  1           1        1  1           1  3     2     2     1   |             
      Endometrium, Hyperplasia, Cystic     | 2           1  2        2        2  2     1  1        1     1     2  1   |             
      Epithelium, Hyperplasia              |                                                          3               |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 4     3  3  3     4        4  4  4  4     4  2  4  4  4  4  4  4     2  3|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                                 +                        |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hyperplasia, Plasma Cell             | 2  2     3  2  3        2                             1     2     2  3   |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                      2   |             
      Hemorrhage                           |                                                 2                       2|             
      Hyperplasia, Histiocytic             |                                     2                                    |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 7| 6| 7| 3| 3| 7| 2| 3| 6| 6| 7| 6| 7| 6| 3| 5| 6| 6| 4| 7| 7| 7|             
                             DAY ON TEST   | 4| 2| 5| 2| 5| 2| 4| 5| 2| 0| 0| 0| 0| 2| 6| 2| 1| 2| 4| 1| 8| 0| 2| 2| 0|             
                                           | 6| 9| 0| 7| 2| 7| 3| 4| 9| 1| 9| 3| 7| 9| 0| 9| 8| 1| 1| 1| 8| 5| 7| 7| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Hematopoietic Cell Proliferation     | 2  1  1     1  1     1        2  2  1  1  1     2  3  3  3  2  3        2|             
      Pigmentation                         | 1  2  2  2  1  2  1  1  2     1  1  1  2  1  2  1     1  1  1  1  1  1  1|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Atrophy                              |       2  4  2        2           2     2  2  2  2  2  3     3  3     2  2|             
      Hemorrhage                           |                                                                          |             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    3     2                          2                          1         |             
      Hyperplasia                          | 1  1     3  1     1  1        1        3  1  1        2  1        1  3  2|             
      Inflammation, Chronic Active         |    3                                                                     |             
      Inflammation, Granulomatous          |          2                                                               |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst, Squamous                       |                                                                          |             
      Dermis, Inflammation, Focal          |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 7| 6| 7| 3| 3| 7| 2| 3| 6| 6| 7| 6| 7| 6| 3| 5| 6| 6| 4| 7| 7| 7|             
                             DAY ON TEST   | 4| 2| 5| 2| 5| 2| 4| 5| 2| 0| 0| 0| 0| 2| 6| 2| 1| 2| 4| 1| 8| 0| 2| 2| 0|             
                                           | 6| 9| 0| 7| 2| 7| 3| 4| 9| 1| 9| 3| 7| 9| 0| 9| 8| 1| 1| 1| 8| 5| 7| 7| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Infiltration Cellular, Histiocyte    | 3     2  2  2  2  2     1  1  1  1  2  2  1  2  1  1     2  2  1  2  1   |             
      Inflammation, Chronic Active         |       1        2              1                                          |             
      Inflammation, Granulomatous          |                                           2              1               |             
      Metaplasia, Squamous                 |                                                             2            |             
      Alveolar Epithelium, Hyperplasia     |       1        1                       1  2  1              1     1      |             
      Serosa, Inflammation, Suppurative    |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasopharyngeal Duct, Inflammation,   |                                                                          |             
           Suppurative                     |                                                                          |             
      Olfactory Epithelium, Inflammation,  |                                                                          |             
           Suppurative                     |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |                                        3                                 |             
      Respiratory Epithelium, Metaplasia   |                                                                          |             
      Turbinate, Inflammation, Suppurative |          2                       2                                       |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                               2                                          |             
      Peritracheal Tissue, Inflammation    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  M  +  +  +|             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                    1  1                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Casts Protein                        |    2                    1                                   1            |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |    1  1                 1     1     1  1     1  1           1  1  1  1   |             
      Nephropathy                          |       1  1     1           1  1  1  1  2  1  1  1     1           1  1  1|             
      Pelvis, Dilatation                   |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  14                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 7| 6| 7| 3| 3| 7| 2| 3| 6| 6| 7| 6| 7| 6| 3| 5| 6| 6| 4| 7| 7| 7|             
                             DAY ON TEST   | 4| 2| 5| 2| 5| 2| 4| 5| 2| 0| 0| 0| 0| 2| 6| 2| 1| 2| 4| 1| 8| 0| 2| 2| 0|             
                                           | 6| 9| 0| 7| 2| 7| 3| 4| 9| 1| 9| 3| 7| 9| 0| 9| 8| 1| 1| 1| 8| 5| 7| 7| 5|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
      Pelvis, Inflammation, Suppurative    |                                                       1                  |             
      Transitional Epithelium, Hyperplasia |                         1                                                |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                       2                  |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  15                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 1|                                                                 |            |
                             DAY ON TEST   | 4| 0| 2|                                                                 |            |
                                           | 7| 0| 6|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 0| 0| 0|                                                                 |      A     |
    0 NG/KG                                | 9| 9| 9|                                                                 |      L     |
                                           | 5| 6| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  52        |
      Muscularis, Inflammation             | 1                                                                        |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  52        |
      Parasite Metazoan                    |                                                                          |      2     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  52        |
      Erosion                              |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  52        |
      Serosa, Inflammation, Chronic Active |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |      3  1.3|
      Basophilic Focus                     |                                                                          |      2     |
      Basophilic Focus, Multiple           |                                                                          |      5     |
      Clear Cell Focus                     |                                                                          |      1     |
      Clear Cell Focus, Multiple           |                                                                          |      1     |
      Eosinophilic Focus                   |                                                                          |      6     |
      Eosinophilic Focus, Multiple         |                                                                          |      5     |
      Fatty Change, Diffuse                |       2                                                                  |      5  1.2|
      Fatty Change, Focal                  |                                                                          |      2  1.5|
      Hepatodiaphragmatic Nodule           |                                                                          |      1     |
      Inflammation                         |    1                                                                     |     36  1.1|
      Mixed Cell Focus                     |                                                                          |      4     |
      Mixed Cell Focus, Multiple           | X                                                                        |     17     |
      Necrosis                             |                                                                          |      4  2.3|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  16                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 1|                                                                 |            |
                             DAY ON TEST   | 4| 0| 2|                                                                 |            |
                                           | 7| 0| 6|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 0| 0| 0|                                                                 |      A     |
    0 NG/KG                                | 9| 9| 9|                                                                 |      L     |
                                           | 5| 6| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Pigmentation                         |                                                                          |      1  1.0|
      Bile Duct, Cyst                      |                                                                          |      3  1.7|
      Bile Duct, Fibrosis                  |                                                                          |      4  1.0|
      Bile Duct, Hyperplasia               |                                                                          |      3  1.3|
      Hepatocyte, Degeneration             |                                                                          |      3  2.3|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
      Gingival, Hyperplasia, Squamous      |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  51        |
      Inflammation, Chronic Active         |                                                                          |      5  1.6|
      Acinus, Atrophy                      |                                                                          |      5  2.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  51        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  52        |
      Edema                                |                                                                          |      1  3.0|
      Hyperplasia, Squamous                |                                                                          |      3  1.7|
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Mineralization                       |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  51        |
      Erosion                              |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                                                                          |  12        |
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                                                          |      2  2.5|
      Peridontal Tissue, Inflammation,     |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  17                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 1|                                                                 |            |
                             DAY ON TEST   | 4| 0| 2|                                                                 |            |
                                           | 7| 0| 6|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 0| 0| 0|                                                                 |      A     |
    0 NG/KG                                | 9| 9| 9|                                                                 |      L     |
                                           | 5| 6| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
           Suppurative                     |                                                                          |     10  1.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +                                                                  |  53        |
      Aorta, Mineralization                |                                                                          |      3  1.3|
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  52        |
      Cardiomyopathy                       |                                                                          |      9  1.0|
      Degeneration                         |       2                                                                  |      1  2.0|
      Mineralization                       |                                                                          |      1  2.0|
      Thrombosis                           |                                                                          |      1  2.0|
      Epicardium, Inflammation, Suppurative|       2                                                                  |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  52        |
      Angiectasis                          |                                                                          |     11  1.5|
      Atrophy                              |                                                                          |      1  1.0|
      Degeneration, Cystic                 |                                                                          |     11  2.1|
      Hyperplasia                          | 3                                                                        |     23  1.9|
      Hypertrophy                          | 2                                                                        |     34  1.9|
      Mineralization                       |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |                                                                          |      5  1.2|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  52        |
      Hyperplasia                          |                                                                          |      8  1.5|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  52        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +                                                                  |  47        |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  18                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 1|                                                                 |            |
                             DAY ON TEST   | 4| 0| 2|                                                                 |            |
                                           | 7| 0| 6|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 0| 0| 0|                                                                 |      A     |
    0 NG/KG                                | 9| 9| 9|                                                                 |      L     |
                                           | 5| 6| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Pituitary Gland                         | +  +  +                                                                  |  51        |
      Angiectasis                          |                                                                          |     14  2.1|
      Pars Distalis, Hyperplasia           | 1  1                                                                     |     18  1.9|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  52        |
      C-Cell, Hyperplasia                  | 3                                                                        |     12  1.9|
      Follicular Cell, Hypertrophy         |                                                                          |      9  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  M  +                                                                  |  50        |
      Inflammation                         | 3                                                                        |     28  1.5|
      Duct, Cyst                           |       2                                                                  |     29  1.9|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  52        |
      Atrophy                              | 4  4  4                                                                  |     45  4.0|
      Cyst                                 | 2                                                                        |     12  2.0|
                                           |__________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |   1        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +                                                                  |  52        |
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |     12  1.8|
      Metaplasia, Squamous                 | 1                                                                        |     26  1.6|
      Endometrium, Hyperplasia, Cystic     |                                                                          |     23  1.7|
      Epithelium, Hyperplasia              |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  19                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 1|                                                                 |            |
                             DAY ON TEST   | 4| 0| 2|                                                                 |            |
                                           | 7| 0| 6|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 0| 0| 0|                                                                 |      A     |
    0 NG/KG                                | 9| 9| 9|                                                                 |      L     |
                                           | 5| 6| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
      Hyperplasia                          | 3  3  3                                                                  |     47  3.4|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   2        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +                                                                  |  52        |
      Ectasia                              |                                                                          |      1  2.0|
      Hyperplasia, Plasma Cell             |                                                                          |     18  2.2|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  52        |
      Ectasia                              |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      2  2.0|
      Hyperplasia, Histiocytic             |                                                                          |      3  1.7|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  52        |
      Hematopoietic Cell Proliferation     | 1  1  1                                                                  |     39  1.7|
      Pigmentation                         | 1  1  1                                                                  |     49  1.3|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +                                                                  |  50        |
      Atrophy                              | 2  2  2                                                                  |     37  2.5|
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation                         |       3                                                                  |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  52        |
      Cyst                                 |                                                                          |      8  1.8|
      Hyperplasia                          | 1     1                                                                  |     32  1.4|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Inflammation, Granulomatous          |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +                                                                  |  52        |
      Cyst, Squamous                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  20                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 1|                                                                 |            |
                             DAY ON TEST   | 4| 0| 2|                                                                 |            |
                                           | 7| 0| 6|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 0| 0| 0|                                                                 |      A     |
    0 NG/KG                                | 9| 9| 9|                                                                 |      L     |
                                           | 5| 6| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
      Dermis, Inflammation, Focal          |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
      Hydrocephalus                        |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   2        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  53        |
      Congestion                           |                                                                          |      1  3.0|
      Infiltration Cellular, Histiocyte    |                                                                          |     41  1.7|
      Inflammation, Chronic Active         |                                                                          |      5  1.4|
      Inflammation, Granulomatous          |                                                                          |      3  1.7|
      Metaplasia, Squamous                 |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |     12  1.1|
      Serosa, Inflammation, Suppurative    |       3                                                                  |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
      Nasopharyngeal Duct, Inflammation,   |                                                                          |            |
           Suppurative                     |                                                                          |      1  4.0|
      Olfactory Epithelium, Inflammation,  |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  21                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 1|                                                                 |            |
                             DAY ON TEST   | 4| 0| 2|                                                                 |            |
                                           | 7| 0| 6|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 0| 0| 0|                                                                 |      A     |
    0 NG/KG                                | 9| 9| 9|                                                                 |      L     |
                                           | 5| 6| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
           Suppurative                     |                                                                          |      1  3.0|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      2  2.5|
      Respiratory Epithelium, Metaplasia   |                                                                          |      1  4.0|
      Turbinate, Inflammation, Suppurative |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |      1  2.0|
      Peritracheal Tissue, Inflammation    |       3                                                                  |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +                                                                  |  51        |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  53        |
      Casts Protein                        |                                                                          |      4  1.3|
      Inflammation, Chronic Active         |                                                                          |      2  2.0|
      Mineralization                       | 1  1  1                                                                  |     32  1.0|
      Nephropathy                          |       1                                                                  |     32  1.3|
      Pelvis, Dilatation                   |                                                                          |      2  2.0|
      Pelvis, Inflammation, Suppurative    |                                                                          |      2  1.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      4  2.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  51        |
      Inflammation                         |                                                                          |      4  1.5|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  22                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 7| 7| 0| 7| 3| 6| 7| 5| 4| 7| 5| 7| 6| 7| 7| 7| 6| 2| 5| 5|             
                             DAY ON TEST   | 7| 5| 2| 2| 2| 2| 2| 8| 2| 2| 5| 2| 7| 9| 2| 7| 2| 3| 2| 2| 2| 5| 5| 1| 2|             
                                           | 1| 2| 9| 8| 7| 9| 7| 2| 9| 8| 2| 7| 2| 8| 8| 4| 8| 0| 7| 8| 7| 2| 3| 6| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    30 NG/KG                               | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4|             
                                           | 1| 4| 5| 6| 7| 8| 0| 2| 1| 2| 3| 4| 5| 6| 8| 0| 1| 3| 5| 6| 7| 8| 9| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Inflammation             |                                              1                           |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                    X                     |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Parasite Metazoan                    |                                                             X            |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Inflammation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                         2|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    1        1  2        2                                2               |             
      Basophilic Focus                     |                         X                                      X         |             
      Basophilic Focus, Multiple           |             X                    X           X        X                  |             
      Cholangiofibrosis                    |                                                             2            |             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   |                X                                                        X|             
      Eosinophilic Focus, Multiple         |    X                                                  X                  |             
      Fatty Change, Diffuse                |             1                                1                           |             
      Fatty Change, Focal                  |                                  1                                       |             
      Hepatocyte, Multinucleate            |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation                         | 1  1  1  1  1  1  1           1  1     2  1  1  1  1  1  1  1  1  1  1  1|             
      Mixed Cell Focus                     | X                       X                          X           X         |             
      Mixed Cell Focus, Multiple           |       X  X  X  X                 X        X     X        X  X            |             
      Necrosis                             |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  23                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 7| 7| 0| 7| 3| 6| 7| 5| 4| 7| 5| 7| 6| 7| 7| 7| 6| 2| 5| 5|             
                             DAY ON TEST   | 7| 5| 2| 2| 2| 2| 2| 8| 2| 2| 5| 2| 7| 9| 2| 7| 2| 3| 2| 2| 2| 5| 5| 1| 2|             
                                           | 1| 2| 9| 8| 7| 9| 7| 2| 9| 8| 2| 7| 2| 8| 8| 4| 8| 0| 7| 8| 7| 2| 3| 6| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    30 NG/KG                               | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4|             
                                           | 1| 4| 5| 6| 7| 8| 0| 2| 1| 2| 3| 4| 5| 6| 8| 0| 1| 3| 5| 6| 7| 8| 9| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Pigmentation                         |          2  1                 1     1     1                              |             
      Toxic Hepatopathy                    |    1                                                  1                  |             
      Vacuolization Cytoplasmic            |                                  1                                       |             
      Bile Duct, Cyst                      |                                                       2                  |             
      Bile Duct, Fibrosis                  |          1                                                               |             
      Bile Duct, Hyperplasia               |                                                       3                 1|             
      Hepatocyte, Degeneration             |                                                                          |             
      Hepatocyte, Hypertrophy              |    1                    1     1  1           1     1  1        1     1  2|             
      Oval Cell, Hyperplasia               |                                                                          |             
      Serosa, Inflammation                 | 2                                                                        |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                  X                                       |             
      Inflammation, Chronic Active         |                1                                                         |             
      Acinus, Atrophy                      |                1                                2                        |             
      Acinus, Hyperplasia                  |                                                                          |             
      Artery, Inflammation, Chronic Active |                                           2                       2      |             
      Artery, Mineralization               |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Hyperkeratosis                       |       2                                                                  |             
      Hyperplasia, Squamous                |       2                                                                  |             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +|             
      Erosion                              |                                                                          |             
      Mineralization                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   |             +     +              +        +     +           +     +      |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Suppurative                     |             1     1              2        2     1           2     1      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  24                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 7| 7| 0| 7| 3| 6| 7| 5| 4| 7| 5| 7| 6| 7| 7| 7| 6| 2| 5| 5|             
                             DAY ON TEST   | 7| 5| 2| 2| 2| 2| 2| 8| 2| 2| 5| 2| 7| 9| 2| 7| 2| 3| 2| 2| 2| 5| 5| 1| 2|             
                                           | 1| 2| 9| 8| 7| 9| 7| 2| 9| 8| 2| 7| 2| 8| 8| 4| 8| 0| 7| 8| 7| 2| 3| 6| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    30 NG/KG                               | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4|             
                                           | 1| 4| 5| 6| 7| 8| 0| 2| 1| 2| 3| 4| 5| 6| 8| 0| 1| 3| 5| 6| 7| 8| 9| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1     1        1        1                 1  1        1                  |             
      Degeneration                         |                                                                          |             
      Inflammation                         |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       2     2     2     1                 1     1                    2   |             
      Atrophy                              |          4                                                               |             
      Degeneration, Cystic                 |    2  2                 4        3           2     1     2  2        1   |             
      Hyperplasia                          |    3  4  4     2  2     3        2                       2  3            |             
      Hypertrophy                          | 1  2  3  2     3  2           3        1  2  3  1  3  2  2  2  2     2   |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 1        3  1  2        1                 2        1        2            |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             2                                                            |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    1                                      3                    3         |             
      Cyst                                 |             3                 2                                          |             
      Cytoplasmic Alteration               |                   2                                                      |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Pars Distalis, Hyperplasia           | 1  2     2  1     2     2                    2     3  2     3            |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  25                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 7| 7| 0| 7| 3| 6| 7| 5| 4| 7| 5| 7| 6| 7| 7| 7| 6| 2| 5| 5|             
                             DAY ON TEST   | 7| 5| 2| 2| 2| 2| 2| 8| 2| 2| 5| 2| 7| 9| 2| 7| 2| 3| 2| 2| 2| 5| 5| 1| 2|             
                                           | 1| 2| 9| 8| 7| 9| 7| 2| 9| 8| 2| 7| 2| 8| 8| 4| 8| 0| 7| 8| 7| 2| 3| 6| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    30 NG/KG                               | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4|             
                                           | 1| 4| 5| 6| 7| 8| 0| 2| 1| 2| 3| 4| 5| 6| 8| 0| 1| 3| 5| 6| 7| 8| 9| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Angiectasis                          |                                                                          |             
      C-Cell, Hyperplasia                  | 1  1  3  3     2              2           1  1        2  2  2            |             
      Follicular Cell, Hypertrophy         |    1                             1     2  1  1                       1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |    1  2  1  1     2     1     2           1  2  1  1     1     2  1  2  1|             
      Duct, Cyst                           | 3     3           3     3        2  2  2  1  1  3  3  2           1  2  2|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  3  4  4  4  4  4     4  4  4     4  4  4  4  4  4  4  4  4  4  4  4  4|             
      Cyst                                 | 2              3  2              2                                       |             
      Inflammation, Suppurative            |                                                                          |             
                                           |__________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomyosis                          |                                                                          |             
      Cyst                                 |                                                                          |             
      Inflammation, Suppurative            | 3                 1        1                          3              1   |             
      Metaplasia, Squamous                 | 4  2        1  3  3     1              1  1     3        2  2     1  2   |             
      Ulcer                                | 2                                                                        |             
      Endometrium, Hyperplasia, Cystic     |       2  2  1  1  2     2     3  1     2  3  4  2  3  2  3  1            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 4  3  2  4              3  3  4        3  3  3     3  4        3  4  4  3|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |          +           +        +     +              +                    +|             
      Lumbar, Hyperplasia, Lymphoid        |                                                                         2|             
      Mediastinal, Ectasia                 |                               2                    1                     |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  26                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 7| 7| 0| 7| 3| 6| 7| 5| 4| 7| 5| 7| 6| 7| 7| 7| 6| 2| 5| 5|             
                             DAY ON TEST   | 7| 5| 2| 2| 2| 2| 2| 8| 2| 2| 5| 2| 7| 9| 2| 7| 2| 3| 2| 2| 2| 5| 5| 1| 2|             
                                           | 1| 2| 9| 8| 7| 9| 7| 2| 9| 8| 2| 7| 2| 8| 8| 4| 8| 0| 7| 8| 7| 2| 3| 6| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    30 NG/KG                               | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4|             
                                           | 1| 4| 5| 6| 7| 8| 0| 2| 1| 2| 3| 4| 5| 6| 8| 0| 1| 3| 5| 6| 7| 8| 9| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                2         |             
      Hyperplasia, Plasma Cell             |    2  2  3     2  2        2  2                    2                 2   |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                        2     2                           |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2     1  3  1  1  1     1  2  3  1     3  1  2     1  2  1  1  1  2  2  2|             
      Necrosis                             |                                                                          |             
      Pigmentation                         | 1  2  2  1  2  1  2     1  1     2  1  1  2  1  2  1  1  1  2  2  1  1  1|             
      Lymphoid Follicle, Atrophy           |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2  2     2     3        2        2     3  4  2     2  2     4  2     2  2|             
      Hemorrhage                           |                                                                   1      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                           2                             1|             
      Hyperplasia                          |    1  1  3  2  1     1        2  2     1           1  2     1  1     1  1|             
      Inflammation, Granulomatous          |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst, Squamous                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  27                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 7| 7| 0| 7| 3| 6| 7| 5| 4| 7| 5| 7| 6| 7| 7| 7| 6| 2| 5| 5|             
                             DAY ON TEST   | 7| 5| 2| 2| 2| 2| 2| 8| 2| 2| 5| 2| 7| 9| 2| 7| 2| 3| 2| 2| 2| 5| 5| 1| 2|             
                                           | 1| 2| 9| 8| 7| 9| 7| 2| 9| 8| 2| 7| 2| 8| 8| 4| 8| 0| 7| 8| 7| 2| 3| 6| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    30 NG/KG                               | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4|             
                                           | 1| 4| 5| 6| 7| 8| 0| 2| 1| 2| 3| 4| 5| 6| 8| 0| 1| 3| 5| 6| 7| 8| 9| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Infiltration Cellular, Histiocyte    | 2  2  2  2  1  1  2     2  1  2     2  2  2  1  1  2  2  2  1  2  2  2  2|             
      Inflammation, Chronic Active         | 1                                                                        |             
      Mineralization                       |                                                                          |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     | 1                                                                        |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     |       1  2     1  2     2     1           2  1     2  1     1  1     1   |             
      Serosa, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation      |                                                                         2|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                               1                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Casts Protein                        |                                                                      2   |             
      Inflammation, Chronic Active         |                                        2                                 |             
      Mineralization                       | 1  1  1  1  1  1  1        1  1  1  1  1  1     1  1     1  1           1|             
      Nephropathy                          |    1  2  2     2  2     1     1  1        2     1     1  1  1           2|             
      Pelvis, Dilatation                   |                                                       3                  |             
      Pelvis, Inflammation, Chronic Active |                                                                         2|             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                         2|             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  28                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 7| 7| 7| 7| 7| 0| 7| 3| 6| 7| 5| 4| 7| 5| 7| 6| 7| 7| 7| 6| 2| 5| 5|             
                             DAY ON TEST   | 7| 5| 2| 2| 2| 2| 2| 8| 2| 2| 5| 2| 7| 9| 2| 7| 2| 3| 2| 2| 2| 5| 5| 1| 2|             
                                           | 1| 2| 9| 8| 7| 9| 7| 2| 9| 8| 2| 7| 2| 8| 8| 4| 8| 0| 7| 8| 7| 2| 3| 6| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    30 NG/KG                               | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4|             
                                           | 1| 4| 5| 6| 7| 8| 0| 2| 1| 2| 3| 4| 5| 6| 8| 0| 1| 3| 5| 6| 7| 8| 9| 0| 1|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
      Inflammation                         |                                              1                          3|             
      Transitional Epithelium, Hyperplasia |                                                                         3|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  29                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 2| 7| 4| 7| 4| 3| 3| 3| 3| 2| 7| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 3| 0| 4| 5| 5| 5| 5| 0| 2| 8| 0| 4| 3| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 8| 0| 3| 7| 4| 0| 8| 0| 6| 6| 6| 2| 7| 1| 7| 6| 0| 9| 0| 8| 7| 9| 8| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    30 NG/KG                               | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 8| 8| 8| 9| 9| 9|             
                                           | 2| 3| 4| 5| 7| 9| 0| 1| 3| 4| 5| 6| 1| 2| 4| 5| 7| 8| 9| 6| 8| 9| 0| 1| 2|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Inflammation             |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |       2                                                                  |             
      Parasite Metazoan                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                2                                                         |             
      Inflammation                         |                1                                                         |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                             1        1   |             
      Basophilic Focus                     |                                                                          |             
      Basophilic Focus, Multiple           | X                                                        X               |             
      Cholangiofibrosis                    |                                                                          |             
      Clear Cell Focus                     |                   X                                                      |             
      Eosinophilic Focus                   |    X                                                                 X   |             
      Eosinophilic Focus, Multiple         |                                     X              X  X  X               |             
      Fatty Change, Diffuse                |          1        1                    1              1                  |             
      Fatty Change, Focal                  |                                     1              2     2               |             
      Hepatocyte, Multinucleate            |                                                          1               |             
      Hepatodiaphragmatic Nodule           | X                                                                        |             
      Inflammation                         | 1        1     1           1  1     1  1  1     2     1  1  1  2  1  1   |             
      Mixed Cell Focus                     |                                           X                    X         |             
      Mixed Cell Focus, Multiple           | X        X                                   X     X        X     X     X|             
      Necrosis                             |    3                          1                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  30                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 2| 7| 4| 7| 4| 3| 3| 3| 3| 2| 7| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 3| 0| 4| 5| 5| 5| 5| 0| 2| 8| 0| 4| 3| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 8| 0| 3| 7| 4| 0| 8| 0| 6| 6| 6| 2| 7| 1| 7| 6| 0| 9| 0| 8| 7| 9| 8| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    30 NG/KG                               | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 8| 8| 8| 9| 9| 9|             
                                           | 2| 3| 4| 5| 7| 9| 0| 1| 3| 4| 5| 6| 1| 2| 4| 5| 7| 8| 9| 6| 8| 9| 0| 1| 2|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Pigmentation                         |          1     3                    1                 1           1      |             
      Toxic Hepatopathy                    |                2                                      1  1               |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Bile Duct, Cyst                      |                                                       3        3     2  3|             
      Bile Duct, Fibrosis                  |                2                                                         |             
      Bile Duct, Hyperplasia               |             1                                         1  1               |             
      Hepatocyte, Degeneration             |                2                                                         |             
      Hepatocyte, Hypertrophy              |                2  1                 1  1     1  1  1  1  1  1  1         |             
      Oval Cell, Hyperplasia               |                                                       1                  |             
      Serosa, Inflammation                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |                                        +                                 |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Acinus, Atrophy                      |          1                                                               |             
      Acinus, Hyperplasia                  |    2                                                                     |             
      Artery, Inflammation, Chronic Active |                                                       2                  |             
      Artery, Mineralization               |       2                                                                  |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |             2                                                            |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                               1                                          |             
      Hyperkeratosis                       |                                        2                                 |             
      Hyperplasia, Squamous                |    2                                   2                                 |             
      Inflammation, Chronic Active         |    3                                                                     |             
      Ulcer                                |    2                                                                     |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |    2                                                                     |             
      Mineralization                       |       3                                                                  |             
                                           |__________________________________________________________________________|             
   Tooth                                   |                                     +  +        +           +        +   |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Suppurative                     |                                     1  1        2           1        1   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  31                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 2| 7| 4| 7| 4| 3| 3| 3| 3| 2| 7| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 3| 0| 4| 5| 5| 5| 5| 0| 2| 8| 0| 4| 3| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 8| 0| 3| 7| 4| 0| 8| 0| 6| 6| 6| 2| 7| 1| 7| 6| 0| 9| 0| 8| 7| 9| 8| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    30 NG/KG                               | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 8| 8| 8| 9| 9| 9|             
                                           | 2| 3| 4| 5| 7| 9| 0| 1| 3| 4| 5| 6| 1| 2| 4| 5| 7| 8| 9| 6| 8| 9| 0| 1| 2|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |       3                                                                  |             
                                           |__________________________________________________________________________|             
   Heart                                   |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    1     1     1                          1        1  2  1               |             
      Degeneration                         |       3                                                                  |             
      Inflammation                         |                                                    2                     |             
      Mineralization                       |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                    2                 2  1|             
      Atrophy                              |                2                                                         |             
      Degeneration, Cystic                 |          3                                         2  3     3           3|             
      Hyperplasia                          | 2  3     4  2     1                    2  2        2     1           2  2|             
      Hypertrophy                          | 2  2     2     1  1     1           2  3  1  1  3  3  3  2  3  2  2  2  3|             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |                                        2                             2   |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3        3                                2     2     3           2  2   |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2                                                              2   |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  M  +  +  M  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 3  2        3  2                    1           2                 2  2   |             
      Cyst                                 |                   2                                                      |             
      Cytoplasmic Alteration               |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                         2|             
      Pars Distalis, Hyperplasia           |          2                          3        3  3  4     2  3        3  3|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  32                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 2| 7| 4| 7| 4| 3| 3| 3| 3| 2| 7| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 3| 0| 4| 5| 5| 5| 5| 0| 2| 8| 0| 4| 3| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 8| 0| 3| 7| 4| 0| 8| 0| 6| 6| 6| 2| 7| 1| 7| 6| 0| 9| 0| 8| 7| 9| 8| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    30 NG/KG                               | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 8| 8| 8| 9| 9| 9|             
                                           | 2| 3| 4| 5| 7| 9| 0| 1| 3| 4| 5| 6| 1| 2| 4| 5| 7| 8| 9| 6| 8| 9| 0| 1| 2|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Angiectasis                          |                                                                         2|             
      C-Cell, Hyperplasia                  | 2        2              1              2                       3  1     1|             
      Follicular Cell, Hypertrophy         |                   1                 1     1     1     2                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                              2                           |             
      Inflammation                         | 1  1     1        2  1     2  1     2        1  2  1  1  2  1  1  2  2   |             
      Duct, Cyst                           |    2           2  2  1  2     2  1  2  2           1  1  2     1        1|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4  4  4     4  4  4  4  4  4     4  4  4  4  4     4     4  4  4  4  4|             
      Cyst                                 |    2     3              2                 2  1  1  2     3  3  2        3|             
      Inflammation, Suppurative            |                                              1                           |             
                                           |__________________________________________________________________________|             
   Oviduct                                 |                                              +                           |             
      Inflammation, Suppurative            |                                              1                           |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomyosis                          |                                                                      2   |             
      Cyst                                 |                                     3                                    |             
      Inflammation, Suppurative            |          4     2        1     1        1              3                  |             
      Metaplasia, Squamous                 | 2  2     3  1     2  1  2  1  2        1     2     2  3     1  3     3   |             
      Ulcer                                |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 2  2           2  2  1              4     1                 3  2  2  2  3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       4  3  2  4        3  2  3     4  4  4  2  4  2  4  4  2  3  2      |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
      Lumbar, Hyperplasia, Lymphoid        |                                                                          |             
      Mediastinal, Ectasia                 |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  33                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 2| 7| 4| 7| 4| 3| 3| 3| 3| 2| 7| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 3| 0| 4| 5| 5| 5| 5| 0| 2| 8| 0| 4| 3| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 8| 0| 3| 7| 4| 0| 8| 0| 6| 6| 6| 2| 7| 1| 7| 6| 0| 9| 0| 8| 7| 9| 8| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    30 NG/KG                               | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 8| 8| 8| 9| 9| 9|             
                                           | 2| 3| 4| 5| 7| 9| 0| 1| 3| 4| 5| 6| 1| 2| 4| 5| 7| 8| 9| 6| 8| 9| 0| 1| 2|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             | 2  2        2     2     2  2     2     2        2     2        2  2  2  2|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                         2|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 1  3  2  1     2              3     2  2  3  1  1  1  1  2  1  2  1     1|             
      Necrosis                             |                               2                                          |             
      Pigmentation                         | 2     1  2  3  1  1  2  2  1     1     1  1  1  1  1  2  1  1  1  2  1  1|             
      Lymphoid Follicle, Atrophy           |             3        2     3     3                                       |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    3  4  4  2  3              2  3  2  3  3  2  2           3  4  2     3|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                        2                                 |             
      Hyperplasia                          | 1  2     2     1                 2  1  1  1  2  1     3     1  1  2  1  1|             
      Inflammation, Granulomatous          |             3                                                        3   |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst, Squamous                       |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  34                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 2| 7| 4| 7| 4| 3| 3| 3| 3| 2| 7| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 3| 0| 4| 5| 5| 5| 5| 0| 2| 8| 0| 4| 3| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 8| 0| 3| 7| 4| 0| 8| 0| 6| 6| 6| 2| 7| 1| 7| 6| 0| 9| 0| 8| 7| 9| 8| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    30 NG/KG                               | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 8| 8| 8| 9| 9| 9|             
                                           | 2| 3| 4| 5| 7| 9| 0| 1| 3| 4| 5| 6| 1| 2| 4| 5| 7| 8| 9| 6| 8| 9| 0| 1| 2|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                         2                                                |             
      Infiltration Cellular, Histiocyte    | 2  1     2  3  2  1  1  1  2        2  2  2  1  1  2  2  2  2  2  2  1  1|             
      Inflammation, Chronic Active         |                2              1                                          |             
      Mineralization                       |       3                                                                  |             
      Thrombosis                           |    2           3                                                         |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     | 1  1     1     1                    2              1  2     1  1  1  1  1|             
      Serosa, Inflammation, Chronic Active | 2                                                                        |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation      |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Casts Protein                        |                1                                1                        |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       | 1  1     1  1  1        1  1  1     1        1     1  1  1  1  1  1  1   |             
      Nephropathy                          | 2        1           1     1           1     1     1  2     1        1  1|             
      Pelvis, Dilatation                   |                                                                          |             
      Pelvis, Inflammation, Chronic Active |                                                                   3      |             
      Renal Tubule, Accumulation, Hyaline  |                                                                          |             
          Droplet                          |                                           3                              |             
      Transitional Epithelium, Hyperplasia |                                                                   3      |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  35                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 2| 7| 4| 7| 4| 3| 3| 3| 3| 2| 7| 6| 6| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 2| 2| 2| 3| 0| 4| 5| 5| 5| 5| 0| 2| 8| 0| 4| 3| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 8| 0| 3| 7| 4| 0| 8| 0| 6| 6| 6| 2| 7| 1| 7| 6| 0| 9| 0| 8| 7| 9| 8| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    30 NG/KG                               | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 8| 8| 8| 9| 9| 9|             
                                           | 2| 3| 4| 5| 7| 9| 0| 1| 3| 4| 5| 6| 1| 2| 4| 5| 7| 8| 9| 6| 8| 9| 0| 1| 2|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
      Inflammation                         |                   1  1     1                                      2      |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  36                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7|                                                           |            |
                             DAY ON TEST   | 2| 8| 2| 2| 2|                                                           |            |
                                           | 2| 0| 9| 7| 8|                                                           |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2|                                                           |      A     |
    30 NG/KG                               | 9| 9| 9| 9| 9|                                                           |      L     |
                                           | 3| 4| 5| 7| 8|                                                           |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +                                                            |  55        |
      Muscularis, Inflammation             |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +                                                            |  55        |
      Parasite Metazoan                    |                                                                          |      1     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +                                                            |  55        |
      Mineralization                       |                                                                          |      1  2.0|
      Parasite Metazoan                    |       X                                                                  |      2     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +                                                            |  54        |
      Edema                                |                                                                          |      1  2.0|
      Inflammation                         |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +                                                            |  55        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +                                                            |  54        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +                                                            |  54        |
      Mineralization                       |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |  55        |
      Angiectasis                          |       1                                                                  |      8  1.4|
      Basophilic Focus                     | X        X                                                               |      4     |
      Basophilic Focus, Multiple           |                                                                          |      6     |
      Cholangiofibrosis                    |                                                                          |      1  2.0|
      Clear Cell Focus                     |                                                                          |      1     |
      Eosinophilic Focus                   |                                                                          |      4     |
      Eosinophilic Focus, Multiple         |                                                                          |      6     |
      Fatty Change, Diffuse                |    1                                                                     |      7  1.0|
      Fatty Change, Focal                  | 1        1                                                               |      6  1.3|
      Hepatocyte, Multinucleate            |          1                                                               |      2  1.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  37                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7|                                                           |            |
                             DAY ON TEST   | 2| 8| 2| 2| 2|                                                           |            |
                                           | 2| 0| 9| 7| 8|                                                           |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2|                                                           |      A     |
    30 NG/KG                               | 9| 9| 9| 9| 9|                                                           |      L     |
                                           | 3| 4| 5| 7| 8|                                                           |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Inflammation                         | 1  1  1  1                                                               |     40  1.1|
      Mixed Cell Focus                     |                                                                          |      6     |
      Mixed Cell Focus, Multiple           |          X  X                                                            |     18     |
      Necrosis                             |                                                                          |      2  2.0|
      Pigmentation                         |          1                                                               |     11  1.3|
      Toxic Hepatopathy                    |          1                                                               |      6  1.2|
      Vacuolization Cytoplasmic            |                                                                          |      1  1.0|
      Bile Duct, Cyst                      |          1                                                               |      6  2.3|
      Bile Duct, Fibrosis                  |       1  2                                                               |      4  1.5|
      Bile Duct, Hyperplasia               |       2  2                                                               |      7  1.6|
      Hepatocyte, Degeneration             |                                                                          |      1  2.0|
      Hepatocyte, Hypertrophy              |       1     1                                                            |     23  1.1|
      Oval Cell, Hyperplasia               |                                                                          |      1  1.0|
      Serosa, Inflammation                 |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +                                                            |  55        |
      Basophilic Focus                     |                                                                          |      1     |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Acinus, Atrophy                      |                                                                          |      3  1.3|
      Acinus, Hyperplasia                  |                                                                          |      1  2.0|
      Artery, Inflammation, Chronic Active |             2                                                            |      4  2.0|
      Artery, Mineralization               |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +                                                            |  54        |
      Cyst                                 |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +                                                            |  55        |
      Erosion                              |                                                                          |      1  1.0|
      Hyperkeratosis                       |             1                                                            |      3  1.7|
      Hyperplasia, Squamous                |             2                                                            |      4  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  38                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7|                                                           |            |
                             DAY ON TEST   | 2| 8| 2| 2| 2|                                                           |            |
                                           | 2| 0| 9| 7| 8|                                                           |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2|                                                           |      A     |
    30 NG/KG                               | 9| 9| 9| 9| 9|                                                           |      L     |
                                           | 3| 4| 5| 7| 8|                                                           |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +                                                            |  53        |
      Erosion                              |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                                                                          |  12        |
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |     12  1.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +                                                            |  55        |
      Aorta, Mineralization                |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +                                                            |  54        |
      Cardiomyopathy                       |       1     1                                                            |     16  1.1|
      Degeneration                         |                                                                          |      1  3.0|
      Inflammation                         |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +                                                            |  55        |
      Angiectasis                          |       2  1  1                                                            |     13  1.5|
      Atrophy                              |          1                                                               |      3  2.3|
      Degeneration, Cystic                 |                                                                          |     14  2.4|
      Hyperplasia                          |             2                                                            |     21  2.4|
      Hypertrophy                          | 2  2  2  2  1                                                            |     41  2.0|
      Necrosis                             |             2                                                            |      1  2.0|
      Vacuolization Cytoplasmic            | 1                                                                        |      3  1.7|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +                                                            |  55        |
      Hyperplasia                          |    2  2     2                                                            |     18  2.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  39                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7|                                                           |            |
                             DAY ON TEST   | 2| 8| 2| 2| 2|                                                           |            |
                                           | 2| 0| 9| 7| 8|                                                           |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2|                                                           |      A     |
    30 NG/KG                               | 9| 9| 9| 9| 9|                                                           |      L     |
                                           | 3| 4| 5| 7| 8|                                                           |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Islets, Pancreatic                      | +  +  +  +  +                                                            |  54        |
      Hyperplasia                          |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +                                                            |  50        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +                                                            |  54        |
      Angiectasis                          | 1  2  3     2                                                            |     15  2.1|
      Cyst                                 |                                                                          |      3  2.3|
      Cytoplasmic Alteration               |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia           | 3                                                                        |     20  2.5|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +                                                            |  55        |
      Angiectasis                          |                                                                          |      1  2.0|
      C-Cell, Hyperplasia                  | 1     1     2                                                            |     21  1.7|
      Follicular Cell, Hypertrophy         |          1  1                                                            |     13  1.2|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +                                                            |  55        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation                         |    1     2  2                                                            |     36  1.4|
      Duct, Cyst                           | 2        3  3                                                            |     32  2.0|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +                                                            |  54        |
      Atrophy                              | 4  4  4  4  4                                                            |     49  4.0|
      Cyst                                 |    2  2                                                                  |     17  2.2|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  40                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7|                                                           |            |
                             DAY ON TEST   | 2| 8| 2| 2| 2|                                                           |            |
                                           | 2| 0| 9| 7| 8|                                                           |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2|                                                           |      A     |
    30 NG/KG                               | 9| 9| 9| 9| 9|                                                           |      L     |
                                           | 3| 4| 5| 7| 8|                                                           |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Inflammation, Suppurative            |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +                                                            |  55        |
      Adenomyosis                          |                                                                          |      1  2.0|
      Cyst                                 |                                                                          |      1  3.0|
      Inflammation, Suppurative            |          1                                                               |     12  1.8|
      Metaplasia, Squamous                 | 2  1  2     2                                                            |     33  1.9|
      Ulcer                                |                                                                          |      1  2.0|
      Endometrium, Hyperplasia, Cystic     | 2  1  2  3  1                                                            |     33  2.1|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +                                                            |  55        |
      Hyperplasia                          | 4     3  2                                                               |     37  3.2|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   6        |
      Lumbar, Hyperplasia, Lymphoid        |                                                                          |      1  2.0|
      Mediastinal, Ectasia                 |                                                                          |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +                                                            |  53        |
      Ectasia                              | 3                                                                        |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Hyperplasia, Plasma Cell             |    2                                                                     |     24  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +                                                            |  54        |
      Hemorrhage                           |                                                                          |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +                                                            |  55        |
      Hematopoietic Cell Proliferation     | 3     1  1  1                                                            |     43  1.6|
      Necrosis                             |                                                                          |      1  2.0|
      Pigmentation                         | 1  1  2  1  1                                                            |     50  1.4|
      Lymphoid Follicle, Atrophy           |    2                                                                     |      5  2.6|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +                                                            |  52        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  41                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7|                                                           |            |
                             DAY ON TEST   | 2| 8| 2| 2| 2|                                                           |            |
                                           | 2| 0| 9| 7| 8|                                                           |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2|                                                           |      A     |
    30 NG/KG                               | 9| 9| 9| 9| 9|                                                           |      L     |
                                           | 3| 4| 5| 7| 8|                                                           |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Atrophy                              | 2     2     3                                                            |     34  2.6|
      Hemorrhage                           |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +                                                            |  55        |
      Cyst                                 |                                                                          |      3  1.7|
      Hyperplasia                          | 1  1                                                                     |     33  1.4|
      Inflammation, Granulomatous          |                                                                          |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +                                                            |  55        |
      Cyst, Squamous                       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +                                                            |  55        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +                                                            |  55        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +                                                            |  55        |
      Congestion                           |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    | 2  2  2     2                                                            |     49  1.7|
      Inflammation, Chronic Active         |                                                                          |      3  1.3|
      Mineralization                       |                                                                          |      1  3.0|
      Thrombosis                           |                                                                          |      2  2.5|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  1.0|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Bronchiolar                     | 2  1  1     1                                                            |     29  1.3|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  42                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 7| 7|                                                           |            |
                             DAY ON TEST   | 2| 8| 2| 2| 2|                                                           |            |
                                           | 2| 0| 9| 7| 8|                                                           |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2|                                                           |      A     |
    30 NG/KG                               | 9| 9| 9| 9| 9|                                                           |      L     |
                                           | 3| 4| 5| 7| 8|                                                           |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Serosa, Inflammation, Chronic Active |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +                                                            |  54        |
      Nasolacrimal Duct, Inflammation      |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +                                                            |  55        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +                                                            |  55        |
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +                                                            |  53        |
      Inflammation                         | 1     1                                                                  |      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |  55        |
      Casts Protein                        |                                                                          |      3  1.3|
      Inflammation, Chronic Active         |          2                                                               |      2  2.0|
      Mineralization                       | 1  1  1     1                                                            |     39  1.0|
      Nephropathy                          | 1     2  1  2                                                            |     29  1.3|
      Pelvis, Dilatation                   |                                                                          |      1  3.0|
      Pelvis, Inflammation, Chronic Active |                                                                          |      2  2.5|
      Renal Tubule, Accumulation, Hyaline  |                                                                          |            |
          Droplet                          |                                                                          |      1  3.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +                                                            |  54        |
      Inflammation                         |                                                                          |      6  1.5|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  43                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 6| 5| 7| 7| 6| 3| 7| 7| 3| 5| 5| 7|             
                             DAY ON TEST   | 2| 5| 2| 2| 2| 5| 2| 5| 0| 2| 2| 2| 2| 7| 8| 2| 2| 5| 7| 2| 2| 0| 5| 3| 0|             
                                           | 7| 1| 9| 9| 9| 3| 7| 1| 2| 7| 9| 8| 9| 8| 6| 8| 8| 3| 6| 7| 8| 0| 4| 1| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100                                    | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|             
    NG/KG                                  | 1| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 1| 2| 4| 1| 2| 3| 4| 5| 6| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Squamous         |                                                                         1|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Adenomatous             |                         3                                                |             
      Inflammation                         |                         2                                                |             
      Parasite Metazoan                    |                            X                                             |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Parasite Metazoan                    |                                              X                           |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 1                                                                        |             
      Basophilic Focus                     |                   X        X                                X            |             
      Basophilic Focus, Multiple           |          X           X                                                   |             
      Cholangiofibrosis                    |                                                                          |             
      Cytoplasmic Alteration               |                                                                          |             
      Eosinophilic Focus                   |    X                             X     X  X                             X|             
      Eosinophilic Focus, Multiple         |                   X        X                 X                       X   |             
      Fatty Change, Diffuse                |          1              3        1              2  2  1                  |             
      Fatty Change, Focal                  |          1        2        2           1           1                    2|             
      Hepatocyte, Multinucleate            |          1     1           1     1           1                          2|             
      Inflammation                         | 3  2  1  1  2  2  1  1  1     1  1  1  2  1  1  1  1     1  1  1  1  1  1|             
      Mixed Cell Focus                     | X           X                          X                    X            |             
      Mixed Cell Focus, Multiple           |       X  X     X  X  X     X  X  X  X        X           X        X      |             
      Necrosis                             |    1                    2                                      2         |             
      Pigmentation                         | 2  2  1  1  2  1  1  1        2  1  1  3  2  1  1  1  1  1           1  2|             
      Toxic Hepatopathy                    | 2  1  1     1  1  1        1     1  1  1     1     1     1              1|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  44                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 6| 5| 7| 7| 6| 3| 7| 7| 3| 5| 5| 7|             
                             DAY ON TEST   | 2| 5| 2| 2| 2| 5| 2| 5| 0| 2| 2| 2| 2| 7| 8| 2| 2| 5| 7| 2| 2| 0| 5| 3| 0|             
                                           | 7| 1| 9| 9| 9| 3| 7| 1| 2| 7| 9| 8| 9| 8| 6| 8| 8| 3| 6| 7| 8| 0| 4| 1| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100                                    | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|             
    NG/KG                                  | 1| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 1| 2| 4| 1| 2| 3| 4| 5| 6| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Bile Duct, Fibrosis                  |                                              1                          2|             
      Bile Duct, Hyperplasia               | 1                          2     2           2                           |             
      Hepatocyte, Degeneration             |                                                                          |             
      Hepatocyte, Hypertrophy              | 2  1  1     1  1  1        2     1  1  1     1     1     1  1     1  2  1|             
      Oval Cell, Hyperplasia               | 2                          1                 1  1        1               |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                           +              +               |             
      Artery, Inflammation, Chronic Active |                                                          3               |             
      Fat, Necrosis                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |    +                                                                    +|             
      Gingival, Hyperplasia, Squamous      |                                                                         1|             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                3         |             
      Acinus, Atrophy                      |                                                                3         |             
      Acinus, Hyperplasia                  |                                                                          |             
      Acinus, Vacuolization Cytoplasmic    |                                                 1                        |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Squamous                |          1              3                                                |             
      Inflammation, Chronic Active         |                         2                                                |             
      Mineralization                       |                                                       3                  |             
      Necrosis, Focal                      |                         2                                                |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Focal                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   | +                                   +        +     +  +  +     +        +|             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Suppurative                     | 2                                   1        2     1  2  1     2        1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  45                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 6| 5| 7| 7| 6| 3| 7| 7| 3| 5| 5| 7|             
                             DAY ON TEST   | 2| 5| 2| 2| 2| 5| 2| 5| 0| 2| 2| 2| 2| 7| 8| 2| 2| 5| 7| 2| 2| 0| 5| 3| 0|             
                                           | 7| 1| 9| 9| 9| 3| 7| 1| 2| 7| 9| 8| 9| 8| 6| 8| 8| 3| 6| 7| 8| 0| 4| 1| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100                                    | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|             
    NG/KG                                  | 1| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 1| 2| 4| 1| 2| 3| 4| 5| 6| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |                                                       3                  |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1        1              1        1        1  1     3  1  1           1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       2  2                 2  2     2  1     2  2           2     1      |             
      Atrophy                              |                            2                                   1     1   |             
      Degeneration, Cystic                 |    3     3  1     1        2        2              2                    3|             
      Hyperplasia                          |    2  2  1  3     3  2        1     2           3  1                 1   |             
      Hypertrophy                          | 2     2  3  2  1  2  1     2  1  3  2  1  1  3  2  3     2  2     2  1  2|             
      Inflammation, Suppurative            |                                                                          |             
      Vacuolization Cytoplasmic            |       1        2                                3                        |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                  2                                      2|             
      Hyperplasia                          |          2        3           2           1           1  2               |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +|             
      Hyperplasia                          |                                                       2                  |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 3     2     3     1  1        2  2  3           3     3           3  1   |             
      Cyst                                 |                                                          2               |             
      Cytoplasmic Alteration               |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Pars Distalis, Hyperplasia           |       2        2  3  2  2     3           2        1     2  3            |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                              2  2                       2|             
      C-Cell, Hyperplasia                  | 1  2           2  2                 3              2     1        2      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  46                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 6| 5| 7| 7| 6| 3| 7| 7| 3| 5| 5| 7|             
                             DAY ON TEST   | 2| 5| 2| 2| 2| 5| 2| 5| 0| 2| 2| 2| 2| 7| 8| 2| 2| 5| 7| 2| 2| 0| 5| 3| 0|             
                                           | 7| 1| 9| 9| 9| 3| 7| 1| 2| 7| 9| 8| 9| 8| 6| 8| 8| 3| 6| 7| 8| 0| 4| 1| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100                                    | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|             
    NG/KG                                  | 1| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 1| 2| 4| 1| 2| 3| 4| 5| 6| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Follicle, Cyst                       |                      2                                                   |             
      Follicular Cell, Hyperplasia         |                                                                   1      |             
      Follicular Cell, Hypertrophy         |                1              1  1                 2              3      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Hyperplasia, Squamous                |                      1                                                   |             
      Inflammation                         | 3  1  2     1  2  2  1  2  2  2     2  1     1  2  1  1  2  3  1  2     1|             
      Duct, Cyst                           | 2  2  3     2  2  2  1  2  3     2     2        3  1     2  2     1     2|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4  4     4  4  4  4  4     4  4  4  4  4  4  4  4     4  4  4  4  4   |             
      Cyst                                 |          3                 2  2  2  2           2        1  3            |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                           2                              |             
      Inflammation, Suppurative            |             2           1                 3                              |             
      Metaplasia, Squamous                 |    1        3     2  2        2  3  3     4        2        2        2   |             
      Vacuolization Cytoplasmic            |                                     2                                    |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |    2  2     1  1  2  2  1     2        2     2     2     2  2        2   |             
      Epithelium, Necrosis                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                         3                                                |             
      Hyperplasia                          | 3  4  2     3  4              2     3  1  4  4  3  4  3        4  2  3  2|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                         +                 +                    +  +      |             
      Deep Cervical, Ectasia               |                                                                   2      |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  47                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 6| 5| 7| 7| 6| 3| 7| 7| 3| 5| 5| 7|             
                             DAY ON TEST   | 2| 5| 2| 2| 2| 5| 2| 5| 0| 2| 2| 2| 2| 7| 8| 2| 2| 5| 7| 2| 2| 0| 5| 3| 0|             
                                           | 7| 1| 9| 9| 9| 3| 7| 1| 2| 7| 9| 8| 9| 8| 6| 8| 8| 3| 6| 7| 8| 0| 4| 1| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100                                    | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|             
    NG/KG                                  | 1| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 1| 2| 4| 1| 2| 3| 4| 5| 6| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Inguinal, Hyperplasia, Plasma Cell   |                                                                2         |             
      Inguinal, Pigmentation               |                                                                2         |             
      Mediastinal, Ectasia                 |                         2                                                |             
      Mediastinal, Hemorrhage              |                         2                                                |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +|             
      Ectasia                              |                                                          2               |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             | 2  2  2  2  2     2  2  2     3  2  2  2     2  3                    2  2|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                         3                                                |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 1  1  1  1     1  1  1  1  2  1  2  1     1  3  1  1     1  1  2  1  1  2|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation                         | 1  1  2  2     1  2  2  2  1  2  2  2  2  2  1  3  2  2  2  1  1  2  1  2|             
      Lymphoid Follicle, Atrophy           |                                                       2                  |             
      Red Pulp, Atrophy                    |                                        2                                 |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  M  +  +  +  M  +  +  M  +  +  +  +  M  M  +  +  +  +  +|             
      Atrophy                              | 4  3  2  2     3     3  4  4     2  3     4  4  2  2        2  2  3  2  2|             
      Fibrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          | 1  1     2     1  1  1  1  2     1     2  2  1  2  2     2        2     2|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  48                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 6| 5| 7| 7| 6| 3| 7| 7| 3| 5| 5| 7|             
                             DAY ON TEST   | 2| 5| 2| 2| 2| 5| 2| 5| 0| 2| 2| 2| 2| 7| 8| 2| 2| 5| 7| 2| 2| 0| 5| 3| 0|             
                                           | 7| 1| 9| 9| 9| 3| 7| 1| 2| 7| 9| 8| 9| 8| 6| 8| 8| 3| 6| 7| 8| 0| 4| 1| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100                                    | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|             
    NG/KG                                  | 1| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 1| 2| 4| 1| 2| 3| 4| 5| 6| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
   Skeletal Muscle                         |                                           +                              |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |                                        2                                2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 2  2  1  1  2  2  2  1     1  2  2  2  2  2  1  2  1     2  2     1  2   |             
      Inflammation, Granulomatous          |                                  1                                      2|             
      Metaplasia, Squamous                 |                                                                          |             
      Mineralization                       |                                                       3                  |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     | 2  2  1  1  2  2  2           2  1     2  1  1  2        2  2     1      |             
      Serosa, Fibrosis                     |                      1                          2                        |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasopharyngeal Duct, Inflammation,   |                                                                          |             
           Suppurative                     |                                                                         3|             
      Olfactory Epithelium, Inflammation,  |                                                                          |             
           Suppurative                     |                                                                         3|             
      Respiratory Epithelium, Hyperplasia  |                                                                         2|             
      Respiratory Epithelium, Inflammation,|                                                                          |             
           Suppurative                     |                                                                         3|             
      Turbinate, Inflammation, Suppurative |                                                             2            |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Anterior Chamber, Ciliary Body,      |                                                                          |             
          Cornea, Inflammation, Suppurative| 2                                                                        |             
      Retina, Atrophy                      |             2                                                            |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  49                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 6| 5| 7| 7| 6| 3| 7| 7| 3| 5| 5| 7|             
                             DAY ON TEST   | 2| 5| 2| 2| 2| 5| 2| 5| 0| 2| 2| 2| 2| 7| 8| 2| 2| 5| 7| 2| 2| 0| 5| 3| 0|             
                                           | 7| 1| 9| 9| 9| 3| 7| 1| 2| 7| 9| 8| 9| 8| 6| 8| 8| 3| 6| 7| 8| 0| 4| 1| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100                                    | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|             
    NG/KG                                  | 1| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 8| 9| 1| 2| 4| 1| 2| 3| 4| 5| 6| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 2        1                                                              1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                       X                  |             
      Casts Protein                        |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |    1                                               1                     |             
      Mineralization                       | 1  1  1  1  1  1  1  1  1  1  1     1  1  1  1        3  1     1  1  1  1|             
      Necrosis                             |    2                                                                     |             
      Nephropathy                          | 1  1  2  1  1     2  1     1  2  2  2  2     1  3     4  2  1     1     3|             
      Pelvis, Inflammation, Chronic Active |                                           2  3                           |             
      Transitional Epithelium, Hyperplasia | 1                    1                    2  3                          2|             
                                           |__________________________________________________________________________|             
   Ureter                                  |                                                       +                  |             
      Mineralization                       |                                                       3                  |             
      Transitional Epithelium, Hyperplasia |                                                       2                  |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 2                             1           2  2        2                  |             
      Transitional Epithelium, Hyperplasia |                                                       2                  |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  50                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 6| 6| 7| 5| 1| 7| 7| 3| 6| 7| 7| 6| 7| 7| 4| 5| 7| 6| 5| 5|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 8| 5| 2| 3| 8| 2| 2| 2| 5| 2| 2| 2| 2| 0| 9| 0| 2| 5| 5| 4|             
                                           | 9| 9| 8| 9| 7| 8| 2| 8| 3| 8| 7| 7| 8| 1| 7| 9| 1| 7| 9| 8| 9| 7| 9| 5| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100                                    | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|             
    NG/KG                                  | 0| 6| 7| 8| 9| 1| 2| 3| 4| 7| 1| 2| 3| 4| 5| 1| 2| 3| 4| 6| 7| 8| 0| 3| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Squamous         |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Adenomatous             |                                                                          |             
      Inflammation                         |                                                                          |             
      Parasite Metazoan                    |                                                       X                  |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |    2                                                                     |             
      Parasite Metazoan                    |    X                                         X                           |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |             1                                      1              1      |             
      Basophilic Focus                     |                                  X           X                 X         |             
      Basophilic Focus, Multiple           |          X                                                        X      |             
      Cholangiofibrosis                    |                                                                2         |             
      Cytoplasmic Alteration               |       2                                                                  |             
      Eosinophilic Focus                   |             X     X                                                      |             
      Eosinophilic Focus, Multiple         |                                                       X     X            |             
      Fatty Change, Diffuse                |       1           1           1                 1     1     1            |             
      Fatty Change, Focal                  |    1     2                                                               |             
      Hepatocyte, Multinucleate            |             1                 1  1                          1            |             
      Inflammation                         | 2  1  1  1  1  1  1  1  2  1  2  1     1  1  1  1  1  1  1  1  1  1  1  1|             
      Mixed Cell Focus                     |                                  X                    X           X      |             
      Mixed Cell Focus, Multiple           | X  X     X  X     X           X        X  X        X           X     X  X|             
      Necrosis                             |                                                             2           1|             
      Pigmentation                         | 1  1  1  1  1  1  1  1  1     2  1  1     1  1     2  1     1     1  1   |             
      Toxic Hepatopathy                    |             1        1        1     1     1           1                  |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  51                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 6| 6| 7| 5| 1| 7| 7| 3| 6| 7| 7| 6| 7| 7| 4| 5| 7| 6| 5| 5|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 8| 5| 2| 3| 8| 2| 2| 2| 5| 2| 2| 2| 2| 0| 9| 0| 2| 5| 5| 4|             
                                           | 9| 9| 8| 9| 7| 8| 2| 8| 3| 8| 7| 7| 8| 1| 7| 9| 1| 7| 9| 8| 9| 7| 9| 5| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100                                    | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|             
    NG/KG                                  | 0| 6| 7| 8| 9| 1| 2| 3| 4| 7| 1| 2| 3| 4| 5| 1| 2| 3| 4| 6| 7| 8| 0| 3| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Bile Duct, Fibrosis                  |                                                       1                  |             
      Bile Duct, Hyperplasia               | 1                                                              1  2      |             
      Hepatocyte, Degeneration             |                         2                                                |             
      Hepatocyte, Hypertrophy              |             1  1  1  1     2  1  1  2     1     1     1        1        1|             
      Oval Cell, Hyperplasia               |                      1                                                   |             
                                           |__________________________________________________________________________|             
   Mesentery                               |          +                                   +                           |             
      Artery, Inflammation, Chronic Active |                                              3                           |             
      Fat, Necrosis                        |          3                                                               |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |                +                                                         |             
      Gingival, Hyperplasia, Squamous      |                1                                                         |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                        1                                 |             
      Acinus, Atrophy                      |                                                                          |             
      Acinus, Hyperplasia                  | 3                                                                        |             
      Acinus, Vacuolization Cytoplasmic    |                                                                          |             
      Artery, Inflammation, Chronic Active |                                              3                           |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                2                                                         |             
      Hyperkeratosis                       |                2                                                         |             
      Hyperplasia, Squamous                | 2              3        1           1                                    |             
      Inflammation, Chronic Active         |                2                                                         |             
      Mineralization                       |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Focal                    |       2                                                                  |             
                                           |__________________________________________________________________________|             
   Tooth                                   |                +     +                                                   |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Suppurative                     |                1     1                                                   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  52                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 6| 6| 7| 5| 1| 7| 7| 3| 6| 7| 7| 6| 7| 7| 4| 5| 7| 6| 5| 5|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 8| 5| 2| 3| 8| 2| 2| 2| 5| 2| 2| 2| 2| 0| 9| 0| 2| 5| 5| 4|             
                                           | 9| 9| 8| 9| 7| 8| 2| 8| 3| 8| 7| 7| 8| 1| 7| 9| 1| 7| 9| 8| 9| 7| 9| 5| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100                                    | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|             
    NG/KG                                  | 0| 6| 7| 8| 9| 1| 2| 3| 4| 7| 1| 2| 3| 4| 5| 1| 2| 3| 4| 6| 7| 8| 0| 3| 5|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    1                 1        1              1                 1         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 1  2     2  2  2     1        1  1     1        1        1     2  1  1  1|             
      Atrophy                              |                                                    1                     |             
      Degeneration, Cystic                 |          2                                                     1         |             
      Hyperplasia                          | 2  3     3  3  2  2  2        2        2  2  3  2     3        3  1  2   |             
      Hypertrophy                          | 1  3     3  1  1  2           2  3        2  2  2  2  1  3        1  1  1|             
      Inflammation, Suppurative            |    1                                                                     |             
      Vacuolization Cytoplasmic            |       2                                2                                 |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia                          |             1        2                 2     2                    1      |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                      1   |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  M  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    3              1  3              1  2  2  1        2        3     3   |             
      Cyst                                 |                                                                          |             
      Cytoplasmic Alteration               |             2                                                            |             
      Vacuolization Cytoplasmic            |                                                 1                        |             
      Pars Distalis, Hyperplasia           | 2        2  3           2     2  1     3  3  3     1     2               |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                               2                                          |             
      C-Cell, Hyperplasia                  | 1     1              1                 1     1  1  1                     |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  53                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 6| 6| 7| 5| 1| 7| 7| 3| 6| 7| 7| 6| 7| 7| 4| 5| 7| 6| 5| 5|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 8| 5| 2| 3| 8| 2| 2| 2| 5| 2| 2| 2| 2| 0| 9| 0| 2| 5| 5| 4|             
                                           | 9| 9| 8| 9| 7| 8| 2| 8| 3| 8| 7| 7| 8| 1| 7| 9| 1| 7| 9| 8| 9| 7| 9| 5| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100                                    | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|             
    NG/KG                                  | 0| 6| 7| 8| 9| 1| 2| 3| 4| 7| 1| 2| 3| 4| 5| 1| 2| 3| 4| 6| 7| 8| 0| 3| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
      Follicular Cell, Hypertrophy         | 1        1                                   1  1        2        2  3   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation                         | 1  3  3  2  2     2  1     2     2  2  1        1  3  1  1  3  2     1   |             
      Duct, Cyst                           | 3  3     1  2  2     2     1        2  2           1  2  2  3  1  1  2   |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  3  4  4  4  4  4  4  4  4  4  3     4  4  4  4     4  4     4  4  4  4|             
      Cyst                                 |    3        3        2           3        2  2  3                       2|             
      Artery, Inflammation, Chronic Active |                                              3                           |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Inflammation, Suppurative            | 1                 1        1  1              2  1                 3  2   |             
      Metaplasia, Squamous                 | 1  1              2        2  3        1     3  1     2  1        3  3  2|             
      Vacuolization Cytoplasmic            |                                                 2                        |             
      Artery, Inflammation, Chronic Active |                                              3                           |             
      Endometrium, Hyperplasia, Cystic     | 2  1     3  3     3        1  1  2     1  3     1     1                  |             
      Epithelium, Necrosis                 |                                                 2                        |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hyperplasia                          |             2  4  3     4  4           3  3  4  3     3  4  4  4  4  3  4|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |          +                                   +                           |             
      Deep Cervical, Ectasia               |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  54                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 6| 6| 7| 5| 1| 7| 7| 3| 6| 7| 7| 6| 7| 7| 4| 5| 7| 6| 5| 5|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 8| 5| 2| 3| 8| 2| 2| 2| 5| 2| 2| 2| 2| 0| 9| 0| 2| 5| 5| 4|             
                                           | 9| 9| 8| 9| 7| 8| 2| 8| 3| 8| 7| 7| 8| 1| 7| 9| 1| 7| 9| 8| 9| 7| 9| 5| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100                                    | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|             
    NG/KG                                  | 0| 6| 7| 8| 9| 1| 2| 3| 4| 7| 1| 2| 3| 4| 5| 1| 2| 3| 4| 6| 7| 8| 0| 3| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Inguinal, Hyperplasia, Plasma Cell   |                                                                          |             
      Inguinal, Pigmentation               |                                                                          |             
      Mediastinal, Ectasia                 |          2                                   2                           |             
      Mediastinal, Hemorrhage              |          2                                                               |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                      2                             2           2         |             
      Hyperplasia, Lymphoid                |                         2                                                |             
      Hyperplasia, Plasma Cell             | 2  2        2        2        2  2     2  3  3  2  3           2  2     3|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 1  2     1  1  3  1     3  2  1  1     1  1  3  2  1  1  2  2  2  1  1  2|             
      Hyperplasia, Lymphoid                |                                                 2                        |             
      Pigmentation                         | 2  2  1  1  1  1  1  2  1  1  1  2  2  2  1  1  1  2  2     2  1  2  2  1|             
      Lymphoid Follicle, Atrophy           |                                     2                                    |             
      Red Pulp, Atrophy                    |       2                             2                                    |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3  2  3  4        3     3     4  3  2  2  3  4  2  2  2  3  2  3  2  2  2|             
      Fibrosis                             |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       4                                                                  |             
      Hyperplasia                          |    1           1     1              1  1     1  1  1     1     2  1  1  2|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                                        2                                 |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  55                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 6| 6| 7| 5| 1| 7| 7| 3| 6| 7| 7| 6| 7| 7| 4| 5| 7| 6| 5| 5|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 8| 5| 2| 3| 8| 2| 2| 2| 5| 2| 2| 2| 2| 0| 9| 0| 2| 5| 5| 4|             
                                           | 9| 9| 8| 9| 7| 8| 2| 8| 3| 8| 7| 7| 8| 1| 7| 9| 1| 7| 9| 8| 9| 7| 9| 5| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100                                    | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|             
    NG/KG                                  | 0| 6| 7| 8| 9| 1| 2| 3| 4| 7| 1| 2| 3| 4| 5| 1| 2| 3| 4| 6| 7| 8| 0| 3| 5|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 2  2  1  1  2  2  1  1        2  1  1  2  2  3  2  2  2  2  1  2     3  2|             
      Inflammation, Granulomatous          |                                                                          |             
      Metaplasia, Squamous                 |                                                                2         |             
      Mineralization                       |                                                                          |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     | 2  2        2  1  1           2  1     1  1  2  2  1  2        2     2  1|             
      Serosa, Fibrosis                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasopharyngeal Duct, Inflammation,   |                                                                          |             
           Suppurative                     |                                                                          |             
      Olfactory Epithelium, Inflammation,  |                                                                          |             
           Suppurative                     |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |                                                                          |             
      Respiratory Epithelium, Inflammation,|                                                                          |             
           Suppurative                     |                                                                          |             
      Turbinate, Inflammation, Suppurative |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                        3                                 |             
      Anterior Chamber, Ciliary Body,      |                                                                          |             
          Cornea, Inflammation, Suppurative|                                                                          |             
      Retina, Atrophy                      |          2                                                               |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  56                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 6| 6| 7| 5| 1| 7| 7| 3| 6| 7| 7| 6| 7| 7| 4| 5| 7| 6| 5| 5|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 8| 5| 2| 3| 8| 2| 2| 2| 5| 2| 2| 2| 2| 0| 9| 0| 2| 5| 5| 4|             
                                           | 9| 9| 8| 9| 7| 8| 2| 8| 3| 8| 7| 7| 8| 1| 7| 9| 1| 7| 9| 8| 9| 7| 9| 5| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    100                                    | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|             
    NG/KG                                  | 0| 6| 7| 8| 9| 1| 2| 3| 4| 7| 1| 2| 3| 4| 5| 1| 2| 3| 4| 6| 7| 8| 0| 3| 5|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |    1                          1  1                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                                          |             
      Casts Protein                        |                            1                                             |             
      Inflammation, Chronic Active         |                                              3                           |             
      Inflammation, Suppurative            |                                                                   1      |             
      Mineralization                       | 1  1  1  1  1     1     1  1  1  1     1  1  1  1  1  1  1  1  1     1  1|             
      Necrosis                             |                                                                          |             
      Nephropathy                          | 1  2  1  2  1  1     1        2  1     1  1  3     1     1     1     1  1|             
      Pelvis, Inflammation, Chronic Active |                                                                          |             
      Transitional Epithelium, Hyperplasia |                      2                       2           2               |             
                                           |__________________________________________________________________________|             
   Ureter                                  |                                                                          |             
      Mineralization                       |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1  1                       1        1                    1               |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  57                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 2| 7|                                                                 |            |
                             DAY ON TEST   | 2| 3| 2|                                                                 |            |
                                           | 7| 6| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    100                                    | 9| 9| 9|                                                                 |      L     |
    NG/KG                                  | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  53        |
      Hyperplasia, Focal, Squamous         |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  53        |
      Hyperplasia, Adenomatous             |                                                                          |      1  3.0|
      Inflammation                         |                                                                          |      1  2.0|
      Parasite Metazoan                    |                                                                          |      2     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  53        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Parasite Metazoan                    |                                                                          |      3     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |      4  1.0|
      Basophilic Focus                     |                                                                          |      6     |
      Basophilic Focus, Multiple           |                                                                          |      4     |
      Cholangiofibrosis                    |                                                                          |      1  2.0|
      Cytoplasmic Alteration               |                                                                          |      1  2.0|
      Eosinophilic Focus                   |                                                                          |      7     |
      Eosinophilic Focus, Multiple         |                                                                          |      6     |
      Fatty Change, Diffuse                | 1     2                                                                  |     14  1.4|
      Fatty Change, Focal                  |                                                                          |      8  1.5|
      Hepatocyte, Multinucleate            |                                                                          |     10  1.1|
      Inflammation                         | 1     2                                                                  |     49  1.2|
      Mixed Cell Focus                     |                                                                          |      7     |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  58                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 2| 7|                                                                 |            |
                             DAY ON TEST   | 2| 3| 2|                                                                 |            |
                                           | 7| 6| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    100                                    | 9| 9| 9|                                                                 |      L     |
    NG/KG                                  | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Mixed Cell Focus, Multiple           |       X                                                                  |     25     |
      Necrosis                             |                                                                          |      5  1.6|
      Pigmentation                         | 1     1                                                                  |     41  1.2|
      Toxic Hepatopathy                    | 1     1                                                                  |     22  1.0|
      Bile Duct, Fibrosis                  |                                                                          |      3  1.3|
      Bile Duct, Hyperplasia               |                                                                          |      7  1.6|
      Hepatocyte, Degeneration             |                                                                          |      1  2.0|
      Hepatocyte, Hypertrophy              | 1     1                                                                  |     32  1.2|
      Oval Cell, Hyperplasia               |                                                                          |      6  1.2|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
      Artery, Inflammation, Chronic Active |                                                                          |      2  3.0|
      Fat, Necrosis                        |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   3        |
      Gingival, Hyperplasia, Squamous      |                                                                          |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  53        |
      Inflammation, Chronic Active         |       2                                                                  |      3  2.0|
      Acinus, Atrophy                      |       2                                                                  |      2  2.5|
      Acinus, Hyperplasia                  |                                                                          |      1  3.0|
      Acinus, Vacuolization Cytoplasmic    |                                                                          |      1  1.0|
      Artery, Inflammation, Chronic Active |       3                                                                  |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  53        |
      Edema                                |                                                                          |      1  2.0|
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Hyperplasia, Squamous                |                                                                          |      6  1.8|
      Inflammation, Chronic Active         |                                                                          |      2  2.0|
      Mineralization                       |                                                                          |      1  3.0|
      Necrosis, Focal                      |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  59                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 2| 7|                                                                 |            |
                             DAY ON TEST   | 2| 3| 2|                                                                 |            |
                                           | 7| 6| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    100                                    | 9| 9| 9|                                                                 |      L     |
    NG/KG                                  | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
   Stomach, Glandular                      | +  +  +                                                                  |  53        |
      Metaplasia, Focal                    |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                                                                          |  10        |
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |     10  1.4|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +                                                                  |  53        |
      Aorta, Mineralization                |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  53        |
      Cardiomyopathy                       |       1                                                                  |     17  1.1|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |     25  1.5|
      Atrophy                              | 1                                                                        |      5  1.2|
      Degeneration, Cystic                 |                                                                          |     10  2.0|
      Hyperplasia                          |                                                                          |     27  2.1|
      Hypertrophy                          | 2     1                                                                  |     40  1.9|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Vacuolization Cytoplasmic            |                                                                          |      5  2.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |      2  2.0|
      Hyperplasia                          |                                                                          |     11  1.7|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  53        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +                                                                  |  48        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  60                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 2| 7|                                                                 |            |
                             DAY ON TEST   | 2| 3| 2|                                                                 |            |
                                           | 7| 6| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    100                                    | 9| 9| 9|                                                                 |      L     |
    NG/KG                                  | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Hyperplasia                          |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |     22  2.2|
      Cyst                                 |                                                                          |      1  2.0|
      Cytoplasmic Alteration               |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |                                                                          |      1  1.0|
      Pars Distalis, Hyperplasia           | 3     2                                                                  |     23  2.2|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  A  +                                                                  |  52        |
      Angiectasis                          |                                                                          |      4  2.0|
      C-Cell, Hyperplasia                  | 1     2                                                                  |     17  1.5|
      Follicle, Cyst                       |                                                                          |      1  2.0|
      Follicular Cell, Hyperplasia         |                                                                          |      1  1.0|
      Follicular Cell, Hypertrophy         |       1                                                                  |     13  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +                                                                  |  52        |
      Hyperplasia, Squamous                |                                                                          |      1  1.0|
      Inflammation                         |                                                                          |     39  1.7|
      Duct, Cyst                           |       3                                                                  |     34  2.0|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  53        |
      Atrophy                              | 4  4  4                                                                  |     46  4.0|
      Cyst                                 |       3                                                                  |     17  2.4|
      Artery, Inflammation, Chronic Active |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +                                                                  |  53        |
      Erosion                              |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |     11  1.6|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  61                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 2| 7|                                                                 |            |
                             DAY ON TEST   | 2| 3| 2|                                                                 |            |
                                           | 7| 6| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    100                                    | 9| 9| 9|                                                                 |      L     |
    NG/KG                                  | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Metaplasia, Squamous                 |       2                                                                  |     25  2.1|
      Vacuolization Cytoplasmic            |                                                                          |      2  2.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  3.0|
      Endometrium, Hyperplasia, Cystic     | 2     2                                                                  |     28  1.8|
      Epithelium, Necrosis                 |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
      Fibrosis                             |                                                                          |      1  3.0|
      Hyperplasia                          | 3  4                                                                     |     35  3.3|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   6        |
      Deep Cervical, Ectasia               |                                                                          |      1  2.0|
      Inguinal, Hyperplasia, Plasma Cell   |                                                                          |      1  2.0|
      Inguinal, Pigmentation               |                                                                          |      1  2.0|
      Mediastinal, Ectasia                 |                                                                          |      3  2.0|
      Mediastinal, Hemorrhage              |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  51        |
      Ectasia                              |                                                                          |      4  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Hyperplasia, Plasma Cell             | 2                                                                        |     31  2.2|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  52        |
      Atrophy                              |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  52        |
      Hematopoietic Cell Proliferation     | 2     1                                                                  |     46  1.4|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Pigmentation                         | 1  1  1                                                                  |     51  1.5|
      Lymphoid Follicle, Atrophy           |       2                                                                  |      3  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  62                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 2| 7|                                                                 |            |
                             DAY ON TEST   | 2| 3| 2|                                                                 |            |
                                           | 7| 6| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    100                                    | 9| 9| 9|                                                                 |      L     |
    NG/KG                                  | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Red Pulp, Atrophy                    |       2                                                                  |      4  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | M  +  +                                                                  |  46        |
      Atrophy                              |       4                                                                  |     41  2.8|
      Fibrosis                             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  53        |
      Cyst                                 |                                                                          |      1  4.0|
      Hyperplasia                          |                                                                          |     30  1.4|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +                                                                  |  53        |
      Ulcer                                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
      Osteopetrosis                        |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
      Hydrocephalus                        |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  53        |
      Infiltration Cellular, Histiocyte    | 2     2                                                                  |     45  1.7|
      Inflammation, Granulomatous          |                                                                          |      2  1.5|
      Metaplasia, Squamous                 |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  63                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 2| 7|                                                                 |            |
                             DAY ON TEST   | 2| 3| 2|                                                                 |            |
                                           | 7| 6| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    100                                    | 9| 9| 9|                                                                 |      L     |
    NG/KG                                  | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Bronchiolar                     | 2     2                                                                  |     34  1.6|
      Serosa, Fibrosis                     |                                                                          |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  52        |
      Nasopharyngeal Duct, Inflammation,   |                                                                          |            |
           Suppurative                     |                                                                          |      1  3.0|
      Olfactory Epithelium, Inflammation,  |                                                                          |            |
           Suppurative                     |                                                                          |      1  3.0|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      1  2.0|
      Respiratory Epithelium, Inflammation,|                                                                          |            |
           Suppurative                     |                                                                          |      1  3.0|
      Turbinate, Inflammation, Suppurative |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +                                                                  |  53        |
      Atrophy                              |                                                                          |      1  3.0|
      Anterior Chamber, Ciliary Body,      |                                                                          |            |
          Cornea, Inflammation, Suppurative|                                                                          |      1  2.0|
      Retina, Atrophy                      |       3                                                                  |      3  2.3|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |      6  1.2|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  53        |
      Calculus Micro Observation Only      |                                                                          |      1     |
      Casts Protein                        |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      3  1.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  64                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 2| 7|                                                                 |            |
                             DAY ON TEST   | 2| 3| 2|                                                                 |            |
                                           | 7| 6| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    100                                    | 9| 9| 9|                                                                 |      L     |
    NG/KG                                  | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
      Mineralization                       | 1     1                                                                  |     44  1.0|
      Necrosis                             |                                                                          |      1  2.0|
      Nephropathy                          | 1     2                                                                  |     38  1.5|
      Pelvis, Inflammation, Chronic Active |                                                                          |      2  2.5|
      Transitional Epithelium, Hyperplasia |                                                                          |      8  1.9|
                                           |__________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
      Mineralization                       |                                                                          |      1  3.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |     10  1.4|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  65                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 5| 4| 7| 6| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 5| 4| 6| 7| 5| 7| 6| 6|             
                             DAY ON TEST   | 2| 2| 9| 5| 0| 2| 6| 6| 2| 2| 2| 9| 2| 2| 5| 2| 0| 7| 4| 0| 2| 7| 2| 5| 5|             
                                           | 7| 7| 2| 9| 5| 7| 0| 0| 9| 7| 8| 5| 8| 7| 8| 9| 0| 4| 8| 4| 7| 6| 8| 8| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    175                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 4|             
    NG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 3| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Inflammation             |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                          X               |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |       2                                                                  |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                                                                          |             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                            X                 X                          X|             
      Basophilic Focus, Multiple           |                                                          X               |             
      Cholangiofibrosis                    | 2                                                                        |             
      Cytoplasmic Alteration               |             2                                                            |             
      Eosinophilic Focus                   |                   X                                                      |             
      Eosinophilic Focus, Multiple         |       X  X     X                 X              X  X     X  X        X  X|             
      Fatty Change, Diffuse                |          1           1  1  1  1        1     1  1        1     1  2  1   |             
      Fatty Change, Focal                  |                   1                 2                                    |             
      Hepatocyte, Multinucleate            |                                  1           1  1        1  1            |             
      Hepatodiaphragmatic Nodule           |                   X                                                      |             
      Hyperplasia, Nodular                 |                X                                                         |             
      Inflammation                         | 1  2  2  1  1  1  1  1  2  1  1  1  1  1     1  1  1  1  1  1  1  1  1  1|             
      Mixed Cell Focus                     |                                                    X                     |             
      Mixed Cell Focus, Multiple           | X  X              X  X  X  X  X     X  X     X  X     X           X  X   |             
      Necrosis                             |       3  1                                      1        2     2         |             
      Pigmentation                         | 2  1  2     1  1  1  1  2  2  2  2  2  2  2  2  1        1  2  1     1  1|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  66                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 5| 4| 7| 6| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 5| 4| 6| 7| 5| 7| 6| 6|             
                             DAY ON TEST   | 2| 2| 9| 5| 0| 2| 6| 6| 2| 2| 2| 9| 2| 2| 5| 2| 0| 7| 4| 0| 2| 7| 2| 5| 5|             
                                           | 7| 7| 2| 9| 5| 7| 0| 0| 9| 7| 8| 5| 8| 7| 8| 9| 0| 4| 8| 4| 7| 6| 8| 8| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    175                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 4|             
    NG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 3| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Toxic Hepatopathy                    | 1  1     1     1  1     1  1  1        1     1  1        1  1  1     1   |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Bile Duct, Cyst                      |                            2                                             |             
      Bile Duct, Fibrosis                  |                                                 1                        |             
      Bile Duct, Hyperplasia               | 2           2           2        1        1     1     1  1               |             
      Hepatocyte, Hypertrophy              |    1     2  1  3  1        1  1     1  1     2  1  2  1  1  1  1  1  2  1|             
      Oval Cell, Hyperplasia               | 1              1        1                                   1            |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                         +                                   +            |             
      Artery, Inflammation, Chronic Active |                         4                                   3            |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |    +                                      +                              |             
      Gingival, Hyperplasia, Squamous      |                                           2                              |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X                                                                        |             
      Inflammation, Chronic Active         |             1           1              1                                 |             
      Acinus, Atrophy                      |             1  1        1              2     1              2            |             
      Acinus, Hyperplasia                  |                                                                          |             
      Acinus, Vacuolization Cytoplasmic    |                                  2              1        1               |             
      Artery, Inflammation, Chronic Active |                         3                    1        3                  |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             1                                                            |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                           1                              |             
      Hyperplasia, Squamous                |          2                                2                              |             
      Inflammation, Chronic Active         |                                           2                              |             
      Mineralization                       |                                                                          |             
      Ulcer                                |                                                                         2|             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |          2                                                               |             
      Mineralization                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   |    +  +                                +  +              +  +            |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  67                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 5| 4| 7| 6| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 5| 4| 6| 7| 5| 7| 6| 6|             
                             DAY ON TEST   | 2| 2| 9| 5| 0| 2| 6| 6| 2| 2| 2| 9| 2| 2| 5| 2| 0| 7| 4| 0| 2| 7| 2| 5| 5|             
                                           | 7| 7| 2| 9| 5| 7| 0| 0| 9| 7| 8| 5| 8| 7| 8| 9| 0| 4| 8| 4| 7| 6| 8| 8| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    175                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 4|             
    NG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 3| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
           Suppurative                     |    1  2                                2  2              1  1            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    1           2                                      1  1  2  1  1     1|             
      Artery, Inflammation, Chronic Active |             2                                                            |             
      Epicardium, Inflammation, Suppurative|                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    2              2        2        2  2  2  2              1           2|             
      Atrophy                              |       1                                                                  |             
      Degeneration, Cystic                 | 3                    4  3     3     4  4                                 |             
      Hyperplasia                          | 1     2              1           1  3  4     2  2  1              2  1  1|             
      Hypertrophy                          | 2  2        2  3  2  2  3  3  3  2  4  2  1  3     1     2  2  1  1  1  1|             
      Necrosis                             |                                                          3               |             
      Vacuolization Cytoplasmic            |                                        2                                2|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                   2      |             
      Hyperplasia                          |                2           2                                   3  2  1   |             
      Necrosis                             |                                                          3               |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                          1               |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M|             
      Hyperplasia                          |          1                                                               |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 1              3        1  3  3                             3            |             
      Cyst                                 |                                                 1                        |             
      Cytoplasmic Alteration               |                               2                                          |             
      Pars Distalis, Hyperplasia           |    3              3     2           2  2  2     2     1        1         |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  68                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 5| 4| 7| 6| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 5| 4| 6| 7| 5| 7| 6| 6|             
                             DAY ON TEST   | 2| 2| 9| 5| 0| 2| 6| 6| 2| 2| 2| 9| 2| 2| 5| 2| 0| 7| 4| 0| 2| 7| 2| 5| 5|             
                                           | 7| 7| 2| 9| 5| 7| 0| 0| 9| 7| 8| 5| 8| 7| 8| 9| 0| 4| 8| 4| 7| 6| 8| 8| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    175                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 4|             
    NG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 3| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      C-Cell, Hyperplasia                  |                   1     2     2                          1  2     2  2  1|             
      Follicular Cell, Hyperplasia         |                               1                                          |             
      Follicular Cell, Hypertrophy         | 2  1        1     1     1  2  1  1  1  1                    1        1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |          1        2  1  2  2           2  2  2     1  1     2     3  3   |             
      Duct, Cyst                           | 2  2  1  1     2  2  2  3  2  3        2  2  2  1  1  2  2  2  2     1  2|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4  4           4  4  4  4  4  4  4  4     4  4  4  4  3  4  4     4  4|             
      Cyst                                 |    2  2        3        2                                      3  2      |             
      Inflammation, Chronic Active         |                2                                                         |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomyosis                          |       4                                                                  |             
      Hemorrhage                           |                                                                2         |             
      Inflammation, Chronic Active         | 3  3                                                                     |             
      Inflammation, Suppurative            | 3  2  2              2     3     2                    1     2  2        1|             
      Metaplasia, Squamous                 |    3  3        1  1     4  4  2  4  1  1     1        1  2  4  3         |             
      Thrombosis                           |                                                                2         |             
      Endometrium, Hyperplasia, Cystic     | 3                    4        2     3  3     3     3  2  1           2  3|             
      Epithelium, Hyperplasia              |    3                                                                     |             
      Epithelium, Necrosis                 |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2  3  4  4  4  4  2  4  3  3  2  4  2  3  4  2  3  4  4  3  4  3     3  4|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  69                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 5| 4| 7| 6| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 5| 4| 6| 7| 5| 7| 6| 6|             
                             DAY ON TEST   | 2| 2| 9| 5| 0| 2| 6| 6| 2| 2| 2| 9| 2| 2| 5| 2| 0| 7| 4| 0| 2| 7| 2| 5| 5|             
                                           | 7| 7| 2| 9| 5| 7| 0| 0| 9| 7| 8| 5| 8| 7| 8| 9| 0| 4| 8| 4| 7| 6| 8| 8| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    175                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 4|             
    NG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 3| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
   Lymph Node                              |          +  +                          +                             +   |             
      Ectasia                              |             2                                                            |             
      Lumbar, Hyperplasia, Plasma Cell     |                                                                      2   |             
      Mediastinal, Hemorrhage              |          2                                                               |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                         3                    2                    2      |             
      Hyperplasia, Lymphoid                |             2                                                            |             
      Hyperplasia, Plasma Cell             | 2              2           2        3  2  2  2              2           2|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 1  1  2  2  3  3  1  2  1  2  1  2  1  1     1  1  2  2  1  1  1  1  1  1|             
      Pigmentation                         | 2  2     1  1  1  2  1  1  1  1  1  2  2     2  1  1  1  1  1  1  1  2  1|             
      Lymphoid Follicle, Atrophy           |                                                    1                     |             
      Red Pulp, Atrophy                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Atrophy                              | 3  3  4  2  2  3  3  2  3     4  3  4  4  2  4  2  2  2  4  3     3  2  2|             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                     4                          3         |             
      Hyperplasia                          | 1  1        1  1     1     1  1        1        1  1        2        1  2|             
      Inflammation, Chronic Active         |                                     3                                    |             
      Inflammation, Granulomatous          |                                                                2         |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Suppurative                     |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  70                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 5| 4| 7| 6| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 5| 4| 6| 7| 5| 7| 6| 6|             
                             DAY ON TEST   | 2| 2| 9| 5| 0| 2| 6| 6| 2| 2| 2| 9| 2| 2| 5| 2| 0| 7| 4| 0| 2| 7| 2| 5| 5|             
                                           | 7| 7| 2| 9| 5| 7| 0| 0| 9| 7| 8| 5| 8| 7| 8| 9| 0| 4| 8| 4| 7| 6| 8| 8| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    175                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 4|             
    NG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 3| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 2  2  1  2  1  1  2  1  2  2  1  1  2  2  1  2  2  1     1     1  2  2  2|             
      Inflammation, Chronic Active         |       2                                                                  |             
      Metaplasia, Squamous                 |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                     3                                    |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     | 2  2  1     1  1  3  1  2  1  2  1  3  2  1  2  2  1     1     1  2  3  2|             
      Serosa, Inflammation, Suppurative    |                                                                          |             
      Vein, Thrombosis                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation      |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |                2                                                         |             
      Turbinate, Inflammation, Suppurative |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                       3                  |             
      Retina, Atrophy                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1  1                                         2                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                                          |             
      Casts Protein                        |                1     1     1              2                    1         |             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic Active         |                                           3                              |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  71                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 5| 4| 7| 6| 6| 7| 7| 7| 5| 7| 7| 6| 7| 6| 5| 4| 6| 7| 5| 7| 6| 6|             
                             DAY ON TEST   | 2| 2| 9| 5| 0| 2| 6| 6| 2| 2| 2| 9| 2| 2| 5| 2| 0| 7| 4| 0| 2| 7| 2| 5| 5|             
                                           | 7| 7| 2| 9| 5| 7| 0| 0| 9| 7| 8| 5| 8| 7| 8| 9| 0| 4| 8| 4| 7| 6| 8| 8| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    175                                    | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 4|             
    NG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 3| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
      Mineralization                       | 1  1  1     1  1     1     1  1  1  1  1  1  1  1  1     1  1  1  1  1   |             
      Nephropathy                          | 1  1        1  1        2     2     1  2  1  2  1  1  1  1  3     1      |             
      Pelvis, Inflammation, Chronic Active |                                                                      2  3|             
      Renal Tubule, Dilatation             |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                      3  3|             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation                         |                                                       1              3  3|             
      Transitional Epithelium, Hyperplasia |                                                                      3  2|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  72                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 7| 5| 4| 6| 6| 7| 5| 7| 7| 6| 7| 7| 5| 1| 7| 5| 6| 7| 4| 4| 7| 7|             
                             DAY ON TEST   | 2| 8| 5| 2| 4| 9| 0| 5| 2| 0| 2| 2| 6| 2| 2| 3| 2| 2| 7| 1| 2| 5| 8| 2| 2|             
                                           | 8| 1| 8| 0| 6| 6| 7| 9| 8| 0| 8| 7| 0| 7| 8| 0| 4| 9| 3| 1| 7| 4| 7| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    175                                    | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|             
    NG/KG                                  | 1| 2| 4| 7| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Inflammation             |                                           1                              |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                          3               |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                   2                                                      |             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2                                                                        |             
      Basophilic Focus                     | X                             X                       X                  |             
      Basophilic Focus, Multiple           |                         X                 X                 X  X        X|             
      Cholangiofibrosis                    |                                                                          |             
      Cytoplasmic Alteration               |                                                                          |             
      Eosinophilic Focus                   |                X                                                        X|             
      Eosinophilic Focus, Multiple         | X     X              X              X  X  X                              |             
      Fatty Change, Diffuse                |    1     1        1  1  1  1              1        1        2        1   |             
      Fatty Change, Focal                  | 1                                2        1                              |             
      Hepatocyte, Multinucleate            |    1                 1     1  1  1        1        1        1        1   |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Hyperplasia, Nodular                 |                                                                          |             
      Inflammation                         | 1  2  1  3  1  2  1  1  1  1  1  2  1  1  2  1     1  1  1  2  1  1  1  1|             
      Mixed Cell Focus                     |                                                                          |             
      Mixed Cell Focus, Multiple           | X  X        X  X     X  X     X  X  X  X           X        X        X  X|             
      Necrosis                             |    3     2                                                        3      |             
      Pigmentation                         | 1     2  3           2  1     2  2  1  2  2  1     2  1     2  1     2  2|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  73                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 7| 5| 4| 6| 6| 7| 5| 7| 7| 6| 7| 7| 5| 1| 7| 5| 6| 7| 4| 4| 7| 7|             
                             DAY ON TEST   | 2| 8| 5| 2| 4| 9| 0| 5| 2| 0| 2| 2| 6| 2| 2| 3| 2| 2| 7| 1| 2| 5| 8| 2| 2|             
                                           | 8| 1| 8| 0| 6| 6| 7| 9| 8| 0| 8| 7| 0| 7| 8| 0| 4| 9| 3| 1| 7| 4| 7| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    175                                    | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|             
    NG/KG                                  | 1| 2| 4| 7| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Toxic Hepatopathy                    |       1              1  1     1        1  1        1        2  1     1  1|             
      Artery, Inflammation, Chronic Active |                                                          2               |             
      Bile Duct, Cyst                      |                      2                                                   |             
      Bile Duct, Fibrosis                  |                      1                                                   |             
      Bile Duct, Hyperplasia               |                      1                 2              2              1  1|             
      Hepatocyte, Hypertrophy              |       1     2  2  1     1           2  1  1        1  1  1  1  1     1  1|             
      Oval Cell, Hyperplasia               |                                        2                             1  1|             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +                             +                                          |             
      Gingival, Hyperplasia, Squamous      | 2                                                                        |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Inflammation, Chronic Active         |                               2                                          |             
      Acinus, Atrophy                      |                               3                                          |             
      Acinus, Hyperplasia                  |       2                                                                  |             
      Acinus, Vacuolization Cytoplasmic    |                                                          2               |             
      Artery, Inflammation, Chronic Active |                                                          3               |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                                      2   |             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Mineralization                       |                      1                                                   |             
                                           |__________________________________________________________________________|             
   Tooth                                   | +                                                     +                  |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  74                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 7| 5| 4| 6| 6| 7| 5| 7| 7| 6| 7| 7| 5| 1| 7| 5| 6| 7| 4| 4| 7| 7|             
                             DAY ON TEST   | 2| 8| 5| 2| 4| 9| 0| 5| 2| 0| 2| 2| 6| 2| 2| 3| 2| 2| 7| 1| 2| 5| 8| 2| 2|             
                                           | 8| 1| 8| 0| 6| 6| 7| 9| 8| 0| 8| 7| 0| 7| 8| 0| 4| 9| 3| 1| 7| 4| 7| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    175                                    | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|             
    NG/KG                                  | 1| 2| 4| 7| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
           Suppurative                     | 1                                                     2                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1        1              1     1           1  1           1              2|             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Epicardium, Inflammation, Suppurative|                                                 4                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      1  2        2  2     2        1        2        1  2|             
      Atrophy                              |       1              1                                                   |             
      Degeneration, Cystic                 | 3     2        2              2     2  3                 2               |             
      Hyperplasia                          | 2     2  2  2                    2  2     3  2        1     1        2  4|             
      Hypertrophy                          | 2     3  2  2  3  1  2  2     3  3  3  3  2        1     2  2        2  1|             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia                          |                2              2        2                 2  2           2|             
      Necrosis                             |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M|             
      Hyperplasia                          |                                                          2               |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          3                       2        3                       2  1  3|             
      Cyst                                 |                                                                          |             
      Cytoplasmic Alteration               |                                                                          |             
      Pars Distalis, Hyperplasia           |       3           1           3  3     2     2              2            |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  75                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 7| 5| 4| 6| 6| 7| 5| 7| 7| 6| 7| 7| 5| 1| 7| 5| 6| 7| 4| 4| 7| 7|             
                             DAY ON TEST   | 2| 8| 5| 2| 4| 9| 0| 5| 2| 0| 2| 2| 6| 2| 2| 3| 2| 2| 7| 1| 2| 5| 8| 2| 2|             
                                           | 8| 1| 8| 0| 6| 6| 7| 9| 8| 0| 8| 7| 0| 7| 8| 0| 4| 9| 3| 1| 7| 4| 7| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    175                                    | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|             
    NG/KG                                  | 1| 2| 4| 7| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Cyst                                 |                                                          2               |             
      C-Cell, Hyperplasia                  | 1  2        2  2        3              1  2                 2        2  2|             
      Follicular Cell, Hyperplasia         |                                                                          |             
      Follicular Cell, Hypertrophy         |                   1                 1     1  1                 1         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1     1  1           1  2     2  1  2  1  2        2  1  2     2         |             
      Duct, Cyst                           | 2  2  2  2  1        2        3     1              1  2  3  3  1        3|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4     4  4  4  4  4  4  4  4     4  4  4  4     4  4  4  4  4  4  4  4  4|             
      Cyst                                 | 2        2     2     2        2        2  3        3                 2   |             
      Inflammation, Chronic Active         |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                          2               |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Adenomyosis                          |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                         2  1  3        2  2                 2            |             
      Metaplasia, Squamous                 |       2     2  1  2  3  3  2     4                 2  2        2         |             
      Thrombosis                           |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 3     2  1        1     2     2     3  4  3                 4  1  4      |             
      Epithelium, Hyperplasia              |                                                                          |             
      Epithelium, Necrosis                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    3  3     4  4  2           4  2  3  4     4  3     2  4  3  4  4     2|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  76                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 7| 5| 4| 6| 6| 7| 5| 7| 7| 6| 7| 7| 5| 1| 7| 5| 6| 7| 4| 4| 7| 7|             
                             DAY ON TEST   | 2| 8| 5| 2| 4| 9| 0| 5| 2| 0| 2| 2| 6| 2| 2| 3| 2| 2| 7| 1| 2| 5| 8| 2| 2|             
                                           | 8| 1| 8| 0| 6| 6| 7| 9| 8| 0| 8| 7| 0| 7| 8| 0| 4| 9| 3| 1| 7| 4| 7| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    175                                    | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|             
    NG/KG                                  | 1| 2| 4| 7| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
   Lymph Node                              |       +        +                                                         |             
      Ectasia                              |                                                                          |             
      Lumbar, Hyperplasia, Plasma Cell     |                3                                                         |             
      Mediastinal, Hemorrhage              |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Ectasia                              | 3                                                                        |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                3  2     2     2  4  2  3  2        2        2        2  3|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |             2                                                            |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 1  1  1     2  3  2     1     1  1  1  3     2     1     2  1  3     1  1|             
      Pigmentation                         | 1  1  2  2  1  1  1  3  1  2  1  2  2  1  2  1  1  2  2  1  1  1  2  2  2|             
      Lymphoid Follicle, Atrophy           |                            2                                             |             
      Red Pulp, Atrophy                    |                            2                                             |             
                                           |__________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       3  4  3     2  2  2  3  2  2  3  2  4        2  3  3  4  3  2  2  3|             
      Inflammation                         |                                                 3                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                           3        3                     |             
      Hyperplasia                          | 1  2  1        2  2  1  1  1  1  1  1  1           1  1              1  1|             
      Inflammation, Chronic Active         |                   3                                                      |             
      Inflammation, Granulomatous          |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Suppurative                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  77                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 7| 5| 4| 6| 6| 7| 5| 7| 7| 6| 7| 7| 5| 1| 7| 5| 6| 7| 4| 4| 7| 7|             
                             DAY ON TEST   | 2| 8| 5| 2| 4| 9| 0| 5| 2| 0| 2| 2| 6| 2| 2| 3| 2| 2| 7| 1| 2| 5| 8| 2| 2|             
                                           | 8| 1| 8| 0| 6| 6| 7| 9| 8| 0| 8| 7| 0| 7| 8| 0| 4| 9| 3| 1| 7| 4| 7| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    175                                    | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|             
    NG/KG                                  | 1| 2| 4| 7| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 2  1  1  1  1  1  2  2  3  1  2  3  2  2  1  1     3  2  1  3        2  2|             
      Inflammation, Chronic Active         |                                                                          |             
      Metaplasia, Squamous                 | 2                       1                                                |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     | 2     1  1  1  1     2  3     2  3  2  2  2        3  1  1  2        3  1|             
      Serosa, Inflammation, Suppurative    |                                                 3                        |             
      Vein, Thrombosis                     |                            3                                             |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation      |       2                                                                  |             
      Respiratory Epithelium, Hyperplasia  |                                                                          |             
      Turbinate, Inflammation, Suppurative |                         1                                                |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Retina, Atrophy                      |                                           3                              |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1        1                       1                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |          X                                                               |             
      Casts Protein                        |             1                                                            |             
      Cyst                                 |                      1           2                                       |             
      Inflammation, Chronic Active         |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  78                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 6| 7| 5| 4| 6| 6| 7| 5| 7| 7| 6| 7| 7| 5| 1| 7| 5| 6| 7| 4| 4| 7| 7|             
                             DAY ON TEST   | 2| 8| 5| 2| 4| 9| 0| 5| 2| 0| 2| 2| 6| 2| 2| 3| 2| 2| 7| 1| 2| 5| 8| 2| 2|             
                                           | 8| 1| 8| 0| 6| 6| 7| 9| 8| 0| 8| 7| 0| 7| 8| 0| 4| 9| 3| 1| 7| 4| 7| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    175                                    | 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9|             
    NG/KG                                  | 1| 2| 4| 7| 8| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
      Mineralization                       | 1  1  1  1  1  1  1  1  1  1  1  1     1  1  1     1        1  1  1  1  1|             
      Nephropathy                          | 1  1     2     1  1  2  1  1  1  1     1  1        1     3  1        2  1|             
      Pelvis, Inflammation, Chronic Active |                                                                          |             
      Renal Tubule, Dilatation             | 2                                                                        |             
      Transitional Epithelium, Hyperplasia |                            2                                2            |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                          3               |             
      Hemorrhage                           |                                                          2               |             
      Inflammation                         |                      1                                   3  2            |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  79                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 4|                                                                 |            |
                             DAY ON TEST   | 8| 2| 3|                                                                 |            |
                                           | 5| 7| 6|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    175                                    | 9| 9| 9|                                                                 |      L     |
    NG/KG                                  | 3| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  53        |
      Muscularis, Inflammation             |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  53        |
      Parasite Metazoan                    |                                                                          |      1     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  52        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  51        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  51        |
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |      1  2.0|
      Basophilic Focus                     |    X                                                                     |      7     |
      Basophilic Focus, Multiple           |                                                                          |      6     |
      Cholangiofibrosis                    |                                                                          |      1  2.0|
      Cytoplasmic Alteration               |                                                                          |      1  2.0|
      Eosinophilic Focus                   | X                                                                        |      4     |
      Eosinophilic Focus, Multiple         |    X                                                                     |     17     |
      Fatty Change, Diffuse                |                                                                          |     22  1.1|
      Fatty Change, Focal                  |    2                                                                     |      6  1.5|
      Hepatocyte, Multinucleate            |                                                                          |     14  1.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      1     |
      Hyperplasia, Nodular                 |                                                                          |      1     |
      Inflammation                         | 1  1                                                                     |     50  1.2|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  80                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 4|                                                                 |            |
                             DAY ON TEST   | 8| 2| 3|                                                                 |            |
                                           | 5| 7| 6|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    175                                    | 9| 9| 9|                                                                 |      L     |
    NG/KG                                  | 3| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Mixed Cell Focus                     | X  X                                                                     |      3     |
      Mixed Cell Focus, Multiple           |       X                                                                  |     29     |
      Necrosis                             |                                                                          |      8  2.1|
      Pigmentation                         |    1                                                                     |     39  1.6|
      Toxic Hepatopathy                    |    1                                                                     |     27  1.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
      Bile Duct, Cyst                      |                                                                          |      2  2.0|
      Bile Duct, Fibrosis                  |                                                                          |      2  1.0|
      Bile Duct, Hyperplasia               |                                                                          |     13  1.4|
      Hepatocyte, Hypertrophy              | 1  2                                                                     |     36  1.3|
      Oval Cell, Hyperplasia               |                                                                          |      7  1.1|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Artery, Inflammation, Chronic Active |                                                                          |      2  3.5|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   4        |
      Gingival, Hyperplasia, Squamous      |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  53        |
      Basophilic Focus                     |                                                                          |      1     |
      Inflammation, Chronic Active         |                                                                          |      4  1.3|
      Acinus, Atrophy                      |                                                                          |      7  1.6|
      Acinus, Hyperplasia                  |                                                                          |      1  2.0|
      Acinus, Vacuolization Cytoplasmic    |                                                                          |      4  1.5|
      Artery, Inflammation, Chronic Active |                                                                          |      4  2.5|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  51        |
      Atrophy                              |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  53        |
      Hyperkeratosis                       |                                                                          |      1  1.0|
      Hyperplasia, Squamous                |                                                                          |      2  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  81                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 4|                                                                 |            |
                             DAY ON TEST   | 8| 2| 3|                                                                 |            |
                                           | 5| 7| 6|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    175                                    | 9| 9| 9|                                                                 |      L     |
    NG/KG                                  | 3| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Ulcer                                |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  53        |
      Erosion                              |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |       +                                                                  |   9        |
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Suppurative                     |       1                                                                  |      9  1.4|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  53        |
      Cardiomyopathy                       |                                                                          |     16  1.2|
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
      Epicardium, Inflammation, Suppurative|                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
      Angiectasis                          |    1                                                                     |     19  1.7|
      Atrophy                              |                                                                          |      3  1.0|
      Degeneration, Cystic                 |    2                                                                     |     14  2.8|
      Hyperplasia                          |    3                                                                     |     25  2.0|
      Hypertrophy                          |    2  2                                                                  |     41  2.1|
      Necrosis                             |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic            |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |     11  2.0|
      Necrosis                             |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  82                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 4|                                                                 |            |
                             DAY ON TEST   | 8| 2| 3|                                                                 |            |
                                           | 5| 7| 6|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    175                                    | 9| 9| 9|                                                                 |      L     |
    NG/KG                                  | 3| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  53        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +                                                                  |  46        |
      Hyperplasia                          |                                                                          |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |     12  2.3|
      Cyst                                 |                                                                          |      1  1.0|
      Cytoplasmic Alteration               |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia           |       1                                                                  |     17  2.1|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  51        |
      Cyst                                 |                                                                          |      1  2.0|
      C-Cell, Hyperplasia                  |       2                                                                  |     19  1.8|
      Follicular Cell, Hyperplasia         |                                                                          |      1  1.0|
      Follicular Cell, Hypertrophy         |                                                                          |     17  1.1|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +                                                                  |  50        |
      Inflammation                         |       1                                                                  |     28  1.6|
      Duct, Cyst                           |    2  2                                                                  |     37  1.9|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  52        |
      Atrophy                              | 4  4  4                                                                  |     45  4.0|
      Cyst                                 |                                                                          |     15  2.3|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  83                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 4|                                                                 |            |
                             DAY ON TEST   | 8| 2| 3|                                                                 |            |
                                           | 5| 7| 6|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    175                                    | 9| 9| 9|                                                                 |      L     |
    NG/KG                                  | 3| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
   Uterus                                  | +  +  +                                                                  |  52        |
      Adenomyosis                          |                                                                          |      1  4.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      2  3.0|
      Inflammation, Suppurative            |                                                                          |     16  2.0|
      Metaplasia, Squamous                 | 2     2                                                                  |     28  2.3|
      Thrombosis                           |                                                                          |      1  2.0|
      Endometrium, Hyperplasia, Cystic     | 2                                                                        |     24  2.5|
      Epithelium, Hyperplasia              |                                                                          |      1  3.0|
      Epithelium, Necrosis                 |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
      Hyperplasia                          | 4  3  3                                                                  |     44  3.3|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   6        |
      Ectasia                              |                                                                          |      1  2.0|
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |      2  2.5|
      Mediastinal, Hemorrhage              |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  51        |
      Ectasia                              |                                                                          |      4  2.5|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Hyperplasia, Plasma Cell             |                                                                          |     21  2.3|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  52        |
      Hemorrhage                           |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  53        |
      Hematopoietic Cell Proliferation     | 2  1  1                                                                  |     45  1.5|
      Pigmentation                         | 1  1  1                                                                  |     51  1.4|
      Lymphoid Follicle, Atrophy           |                                                                          |      2  1.5|
      Red Pulp, Atrophy                    |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  84                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 4|                                                                 |            |
                             DAY ON TEST   | 8| 2| 3|                                                                 |            |
                                           | 5| 7| 6|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    175                                    | 9| 9| 9|                                                                 |      L     |
    NG/KG                                  | 3| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  M  +                                                                  |  48        |
      Atrophy                              | 3     2                                                                  |     45  2.8|
      Inflammation                         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  53        |
      Cyst                                 |                                                                          |      4  3.3|
      Hyperplasia                          |                                                                          |     29  1.2|
      Inflammation, Chronic Active         |                                                                          |      2  3.0|
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +                                                                  |  53        |
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Suppurative                     |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  53        |
      Infiltration Cellular, Histiocyte    | 1  2  1                                                                  |     48  1.6|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Metaplasia, Squamous                 |                                                                          |      2  1.5|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  3.0|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Bronchiolar                     |    2                                                                     |     41  1.8|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  85                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 4|                                                                 |            |
                             DAY ON TEST   | 8| 2| 3|                                                                 |            |
                                           | 5| 7| 6|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    175                                    | 9| 9| 9|                                                                 |      L     |
    NG/KG                                  | 3| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Serosa, Inflammation, Suppurative    |                                                                          |      1  3.0|
      Vein, Thrombosis                     |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
      Nasolacrimal Duct, Inflammation      |                                                                          |      1  2.0|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      1  2.0|
      Turbinate, Inflammation, Suppurative |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +                                                                  |  53        |
      Atrophy                              |                                                                          |      1  3.0|
      Retina, Atrophy                      |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |      6  1.2|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  53        |
      Calculus Micro Observation Only      |                                                                          |      1     |
      Casts Protein                        |                                                                          |      6  1.2|
      Cyst                                 |                                                                          |      2  1.5|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Mineralization                       | 1  1  1                                                                  |     44  1.0|
      Nephropathy                          | 1  2                                                                     |     35  1.3|
      Pelvis, Inflammation, Chronic Active |                                                                          |      2  2.5|
      Renal Tubule, Dilatation             |                                                                          |      1  2.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      4  2.5|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  52        |
      Edema                                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  86                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 4|                                                                 |            |
                             DAY ON TEST   | 8| 2| 3|                                                                 |            |
                                           | 5| 7| 6|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    175                                    | 9| 9| 9|                                                                 |      L     |
    NG/KG                                  | 3| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation                         |                                                                          |      6  2.2|
      Transitional Epithelium, Hyperplasia |                                                                          |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  87                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 6| 5| 6| 6| 7| 3| 7| 7| 6| 7| 6| 7| 7| 6| 7| 4| 6| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 1| 3| 8| 4| 0| 0| 2| 0| 2| 0| 0| 2| 8| 2| 2| 5| 2| 5| 6| 0| 2| 2| 2| 2|             
                                           | 2| 9| 0| 8| 1| 7| 7| 7| 1| 7| 9| 7| 7| 0| 7| 9| 8| 7| 4| 5| 3| 9| 7| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    300                                    | 0| 0| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
    NG/KG                                  | 6| 9| 6| 7| 9| 1| 2| 3| 4| 5| 6| 7| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Degeneration             |                                                                2         |             
      Muscularis, Inflammation             |                                                                          |             
      Periesophageal Tissue, Inflammation, |                                                                          |             
           Suppurative                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          2                                                               |             
      Basophilic Focus                     |                      X                          X                        |             
      Basophilic Focus, Multiple           |    X                          X                                          |             
      Cholangiofibrosis                    |                   1                    2                                 |             
      Cytoplasmic Alteration               |                                                                          |             
      Degeneration, Cystic                 |                      1                                                   |             
      Eosinophilic Focus                   |                                                                   X      |             
      Eosinophilic Focus, Multiple         | X  X  X  X     X     X                       X  X  X     X               |             
      Fatty Change, Diffuse                | 2  1     1  1  1     1        1     1  1  1        1  1  2  1  1     1   |             
      Fatty Change, Focal                  |                                                    2              1      |             
      Hepatocyte, Multinucleate            |    2           2     1              2  1     1     1     1        1  1  1|             
      Hyperplasia, Nodular                 |                               X        X                                X|             
      Inflammation                         | 1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|             
      Mixed Cell Focus, Multiple           | X  X     X  X  X  X  X     X     X  X     X  X     X  X        X  X  X   |             
      Necrosis                             |                      1        2                             2            |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  88                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 6| 5| 6| 6| 7| 3| 7| 7| 6| 7| 6| 7| 7| 6| 7| 4| 6| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 1| 3| 8| 4| 0| 0| 2| 0| 2| 0| 0| 2| 8| 2| 2| 5| 2| 5| 6| 0| 2| 2| 2| 2|             
                                           | 2| 9| 0| 8| 1| 7| 7| 7| 1| 7| 9| 7| 7| 0| 7| 9| 8| 7| 4| 5| 3| 9| 7| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    300                                    | 0| 0| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
    NG/KG                                  | 6| 9| 6| 7| 9| 1| 2| 3| 4| 5| 6| 7| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Pigmentation                         | 1  3  1  1  2  2  2  2  1     3  1  2  2  2  2  3  2     3  1  2  2  2  2|             
      Toxic Hepatopathy                    | 1  2  1  1  1  2  1  2        2  1  2  1  2  1  1  2     1     1  1  1  1|             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Bile Duct, Cyst                      |                                                                      2   |             
      Bile Duct, Fibrosis                  |                                                 1                        |             
      Bile Duct, Hyperplasia               |    1                          1           1        1     1              1|             
      Hepatocyte, Degeneration             |                               1                                          |             
      Hepatocyte, Hypertrophy              |    2  1  2  1  3  1  2        2  1  1  1  1  1     1  1  1     1  1  1  1|             
      Oval Cell, Hyperplasia               |    2  1              1        1                                      1  2|             
      Portal, Fibrosis                     |                                        2                                 |             
                                           |__________________________________________________________________________|             
   Mesentery                               | +                                            +                 +         |             
      Artery, Inflammation, Chronic Active | 3                                            3                 3         |             
      Fat, Necrosis                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |                                                                +         |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                          3               |             
      Acinus, Atrophy                      |                                                                          |             
      Acinus, Hyperplasia                  |                                                                          |             
      Acinus, Vacuolization Cytoplasmic    |                      1     1     1           1     1                    1|             
      Artery, Inflammation, Chronic Active | 2                             3              2                 1        4|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Cyst                                 |                                                 2                        |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                                 2                        |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Squamous                |                         1                                                |             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  89                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 6| 5| 6| 6| 7| 3| 7| 7| 6| 7| 6| 7| 7| 6| 7| 4| 6| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 1| 3| 8| 4| 0| 0| 2| 0| 2| 0| 0| 2| 8| 2| 2| 5| 2| 5| 6| 0| 2| 2| 2| 2|             
                                           | 2| 9| 0| 8| 1| 7| 7| 7| 1| 7| 9| 7| 7| 0| 7| 9| 8| 7| 4| 5| 3| 9| 7| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    300                                    | 0| 0| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
    NG/KG                                  | 6| 9| 6| 7| 9| 1| 2| 3| 4| 5| 6| 7| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   |    +     +                                                        +      |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Suppurative                     |    2     2                                                        1      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1     1        1     1                    1  1     1        2  1     1  1|             
      Epicardium, Inflammation, Chronic    |                                                                          |             
          Active                           |                                                                          |             
      Myocardium, Inflammation             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    2                 1  1           2     2                    2     1  2|             
      Atrophy                              |                   3                 1                                   1|             
      Degeneration, Cystic                 |    3  1  2     2  3              1              2                        |             
      Hyperplasia                          |    2           2     2           3        3  2  2  2     2     3  3  2   |             
      Hypertrophy                          | 2  2  3  2     2  2  2     1  2  2  2     2  2  3  2  2        3  1  1  1|             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |    2  2                          2                                   2   |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                   3      |             
      Hyperplasia                          |                            2  2           2     2                 2      |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  M  +  +  +  +  +  +  +  M|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    3           3     2        1  2  3     3  2                           |             
      Cytoplasmic Alteration               |                            2                                            2|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  90                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 6| 5| 6| 6| 7| 3| 7| 7| 6| 7| 6| 7| 7| 6| 7| 4| 6| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 1| 3| 8| 4| 0| 0| 2| 0| 2| 0| 0| 2| 8| 2| 2| 5| 2| 5| 6| 0| 2| 2| 2| 2|             
                                           | 2| 9| 0| 8| 1| 7| 7| 7| 1| 7| 9| 7| 7| 0| 7| 9| 8| 7| 4| 5| 3| 9| 7| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    300                                    | 0| 0| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
    NG/KG                                  | 6| 9| 6| 7| 9| 1| 2| 3| 4| 5| 6| 7| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Necrosis                             |                                                                          |             
      Pigmentation                         |                                                                          |             
      Pars Distalis, Hyperplasia           | 1     1     1     3                          2  1  3     1           2  3|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                2     1        2  1        2  2     3           2     3   |             
      Follicular Cell, Hypertrophy         |    2  2        1  1              1  1     1        2     1     1  1  1  1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |       1     1     2  3  1  2  1  1  1     1  1  2  2  1  1     2  1  2  1|             
      Duct, Cyst                           | 2  3     2  1  1  2  2  2  2  2  1     2  2  2  2  3  2  1     3         |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Atrophy                              |    4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4     4  4  4  4  4|             
      Cyst                                 |             2              2                    3     1              2  3|             
      Inflammation, Chronic Active         |                               3                                          |             
      Necrosis                             |                               4                                          |             
                                           |__________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                    3                     |             
      Inflammation, Chronic Active         |                                                          4               |             
      Inflammation, Suppurative            |                               1  1                          2     2      |             
      Metaplasia, Squamous                 |    3  2  1  2     1     1        1  1           3     1        2     2   |             
      Cervix, Cyst                         |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |          2           3     2  1  1     1  3  1     2  2     4  3  4  1  2|             
                                           |__________________________________________________________________________|             
   Vagina                                  |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  91                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 6| 5| 6| 6| 7| 3| 7| 7| 6| 7| 6| 7| 7| 6| 7| 4| 6| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 1| 3| 8| 4| 0| 0| 2| 0| 2| 0| 0| 2| 8| 2| 2| 5| 2| 5| 6| 0| 2| 2| 2| 2|             
                                           | 2| 9| 0| 8| 1| 7| 7| 7| 1| 7| 9| 7| 7| 0| 7| 9| 8| 7| 4| 5| 3| 9| 7| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    300                                    | 0| 0| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
    NG/KG                                  | 6| 9| 6| 7| 9| 1| 2| 3| 4| 5| 6| 7| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3     4  3  3  3  3  3  4  2  4  3     3  2  2  3  4  4  4  4  3  3  2  3|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                      +                                   +               |             
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                      3                                                   |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
      Mediastinal, Inflammation,           |                                                                          |             
          Suppurative                      |                                                          2               |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                            2                                             |             
      Hemorrhage                           |          2                                                               |             
      Hyperplasia, Lymphoid                |                      2                                                   |             
      Hyperplasia, Plasma Cell             |    2  2  2  2  3              2  1  2        2  2  2     2     2  2  2  2|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                               2                                          |             
      Hyperplasia, Plasma Cell             |                                              2                           |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2     3  1  2        1  3  1  2  2  1     1  2  3  3  2  2     1     1  1|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation                         | 2  2  1  2  1  2  1  1  1  2  1  1  2  2  2  1  1  1  1  1  2  1  1  2  2|             
      Lymphoid Follicle, Atrophy           |                                        2                    2            |             
      Red Pulp, Atrophy                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  M  M  +  +  +  M  +  M  +  +  +  +|             
      Atrophy                              | 4  2  3  3  3  2     4     3  4  3  3        2  3  4     3     4  4  4  4|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                            4                 2                       2   |             
      Fibrosis, Focal                      |                      2                                                   |             
      Hyperplasia                          | 1  1  1        1     1     2  2  1  2  1                          1     1|             
      Inflammation, Chronic Active         |                                                                      2   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  92                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 6| 5| 6| 6| 7| 3| 7| 7| 6| 7| 6| 7| 7| 6| 7| 4| 6| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 1| 3| 8| 4| 0| 0| 2| 0| 2| 0| 0| 2| 8| 2| 2| 5| 2| 5| 6| 0| 2| 2| 2| 2|             
                                           | 2| 9| 0| 8| 1| 7| 7| 7| 1| 7| 9| 7| 7| 0| 7| 9| 8| 7| 4| 5| 3| 9| 7| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    300                                    | 0| 0| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
    NG/KG                                  | 6| 9| 6| 7| 9| 1| 2| 3| 4| 5| 6| 7| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Infiltration Cellular, Histiocyte    | 2  2  1  2  1  1  1  2     2  2  1  2  1     2  2  2  1  2     2  1  2  2|             
      Inflammation, Chronic Active         |                                                                          |             
      Metaplasia, Squamous                 |                                                                         2|             
      Alveolar Epithelium, Hyperplasia     |                1                                                         |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     | 1  1  1  3  1     2  2     3  2  2  1        2  3  2  1        2  1  2  2|             
      Serosa, Inflammation, Suppurative    |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation      |             2                                                            |             
      Nasolacrimal Duct, Respiratory       |                                                                          |             
          Epithelium, Hyperplasia          |                                                 2                        |             
      Respiratory Epithelium, Hyperplasia  |                   2                                2                     |             
      Respiratory Epithelium, Inflammation,|                                                                          |             
           Suppurative                     |                                                    2                     |             
      Respiratory Epithelium, Metaplasia   |                                                          2               |             
      Turbinate, Inflammation, Suppurative |                   2                                      3               |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  93                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 6| 5| 6| 6| 7| 3| 7| 7| 6| 7| 6| 7| 7| 6| 7| 4| 6| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 1| 3| 8| 4| 0| 0| 2| 0| 2| 0| 0| 2| 8| 2| 2| 5| 2| 5| 6| 0| 2| 2| 2| 2|             
                                           | 2| 9| 0| 8| 1| 7| 7| 7| 1| 7| 9| 7| 7| 0| 7| 9| 8| 7| 4| 5| 3| 9| 7| 9| 9|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    300                                    | 0| 0| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
    NG/KG                                  | 6| 9| 6| 7| 9| 1| 2| 3| 4| 5| 6| 7| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
   Ear                                     |                         +                                                |             
      Inflammation                         |                         1                                                |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cataract                             |                                                                          |             
      Edema                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |    1                             1                                       |             
                                           |__________________________________________________________________________|             
   Lacrimal Gland                          |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |    1  1  1  1  1  1  1     1     1  1  1  1     1  1  1  1  1     1  1  1|             
      Necrosis                             |                                                                          |             
      Nephropathy                          | 3  1  1  1  1  1  1  2        2  1     1  1  3  1  2  1        2  1  2  2|             
      Papilla, Angiectasis                 |                                                                          |             
      Pelvis, Inflammation, Suppurative    |                         2                                                |             
      Transitional Epithelium, Hyperplasia |                   2     2     2                    1                     |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Inflammation                         |             1     2     3                             1                 1|             
      Transitional Epithelium, Hyperplasia |                         3                                                |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  94                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 3| 6| 1| 5| 6| 7| 5| 7| 7| 6| 5| 7| 6| 6| 5| 6| 2| 0| 3| 7| 6|             
                             DAY ON TEST   | 2| 5| 2| 5| 3| 5| 6| 3| 5| 2| 4| 2| 2| 4| 3| 1| 1| 1| 9| 8| 4| 4| 2| 2| 4|             
                                           | 7| 4| 7| 9| 1| 8| 3| 1| 9| 9| 6| 7| 9| 5| 1| 5| 8| 8| 9| 8| 7| 0| 8| 2| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    300                                    | 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|             
    NG/KG                                  | 5| 1| 3| 4| 9| 1| 2| 3| 5| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Degeneration             |                                                                          |             
      Muscularis, Inflammation             |                         1                                                |             
      Periesophageal Tissue, Inflammation, |                                                                          |             
           Suppurative                     |                   3                                                      |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                           X                              |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                      2                                                   |             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                         2                                                |             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                                                                          |             
      Basophilic Focus, Multiple           |                                                                          |             
      Cholangiofibrosis                    |                                                    2                     |             
      Cytoplasmic Alteration               |                                                          2               |             
      Degeneration, Cystic                 |                                                                          |             
      Eosinophilic Focus                   |                                                       X                  |             
      Eosinophilic Focus, Multiple         |                         X  X              X                          X   |             
      Fatty Change, Diffuse                |    1  1  1     1  2        1        1  1     1        1  2           1   |             
      Fatty Change, Focal                  |                                        2                                 |             
      Hepatocyte, Multinucleate            | 1        1  2                       1  1     1        2  1               |             
      Hyperplasia, Nodular                 |                                                                          |             
      Inflammation                         | 1  1  1  1  2  1        1  1  1  1  1  1  2  1  2  3  2  2  1  1  2  1  1|             
      Mixed Cell Focus, Multiple           | X  X  X  X     X           X  X  X  X                    X               |             
      Necrosis                             | 2                                2     1        2  2  3  1              3|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  95                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 3| 6| 1| 5| 6| 7| 5| 7| 7| 6| 5| 7| 6| 6| 5| 6| 2| 0| 3| 7| 6|             
                             DAY ON TEST   | 2| 5| 2| 5| 3| 5| 6| 3| 5| 2| 4| 2| 2| 4| 3| 1| 1| 1| 9| 8| 4| 4| 2| 2| 4|             
                                           | 7| 4| 7| 9| 1| 8| 3| 1| 9| 9| 6| 7| 9| 5| 1| 5| 8| 8| 9| 8| 7| 0| 8| 2| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    300                                    | 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|             
    NG/KG                                  | 5| 1| 3| 4| 9| 1| 2| 3| 5| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Pigmentation                         | 2  2  2  1  2  1     2  1  2  2  2  2  2  2  2  2  3  2  3  1        1  2|             
      Toxic Hepatopathy                    | 1  1  1  1     1           1     1  1  2     1  1  2  2  1           1   |             
      Artery, Inflammation, Chronic Active |                                                    2                     |             
      Bile Duct, Cyst                      |                            2                       4                     |             
      Bile Duct, Fibrosis                  |                                                                          |             
      Bile Duct, Hyperplasia               | 1  1           1           1                       3     2        1      |             
      Hepatocyte, Degeneration             |                                                                          |             
      Hepatocyte, Hypertrophy              | 1  3  1  2     2     1  1  2  2  1  1  2  1     1  2  1  1        2  1   |             
      Oval Cell, Hyperplasia               |       1                    1                 1                           |             
      Portal, Fibrosis                     |                                                    2                     |             
                                           |__________________________________________________________________________|             
   Mesentery                               | +                                                  +     +               |             
      Artery, Inflammation, Chronic Active | 3                                                  4                     |             
      Fat, Necrosis                        |                                                          3               |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |                                                 +                        |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                    2     1               |             
      Acinus, Atrophy                      |                                                    3     2               |             
      Acinus, Hyperplasia                  |          2                                                               |             
      Acinus, Vacuolization Cytoplasmic    |       1                                                  1               |             
      Artery, Inflammation, Chronic Active | 2                                                  3                     |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                          2               |             
      Cyst                                 |                                                                          |             
      Inflammation, Acute                  |                                                                1         |             
      Inflammation, Chronic Active         |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                      2                                                   |             
      Hyperkeratosis                       | 2                                               2        1               |             
      Hyperplasia, Squamous                | 2                    2                          2        2               |             
      Inflammation, Chronic Active         | 2                                                                        |             
      Ulcer                                | 3                                               2        2               |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  96                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 3| 6| 1| 5| 6| 7| 5| 7| 7| 6| 5| 7| 6| 6| 5| 6| 2| 0| 3| 7| 6|             
                             DAY ON TEST   | 2| 5| 2| 5| 3| 5| 6| 3| 5| 2| 4| 2| 2| 4| 3| 1| 1| 1| 9| 8| 4| 4| 2| 2| 4|             
                                           | 7| 4| 7| 9| 1| 8| 3| 1| 9| 9| 6| 7| 9| 5| 1| 5| 8| 8| 9| 8| 7| 0| 8| 2| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    300                                    | 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|             
    NG/KG                                  | 5| 1| 3| 4| 9| 1| 2| 3| 5| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   |       +                 +  +              +     +  +                     |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Suppurative                     |       1                 1  1              1     2  2                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    1  1     1              1     1  1        1  1  2                 1  1|             
      Epicardium, Inflammation, Chronic    |                                                                          |             
          Active                           |                   3                                                      |             
      Myocardium, Inflammation             |                                                             3            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 1     1                    1     1  1     2     1        1           2   |             
      Atrophy                              |          2                                         1                     |             
      Degeneration, Cystic                 |    2     3           1                       3        3              3   |             
      Hyperplasia                          | 3  2     4  1              2           2  3     2        3           2   |             
      Hypertrophy                          |    2  1  1     1     2  2  2  1  2  1  2  1  3  2  1  3              4  2|             
      Necrosis                             |                                                                         2|             
      Vacuolization Cytoplasmic            |    2              2     2                                               1|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                     2                                    |             
      Hyperplasia                          |                1                    2        2     2                 1   |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            3                                             |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 3     2                 3           2        2           1              3|             
      Cytoplasmic Alteration               |                                        2                                 |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  97                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 3| 6| 1| 5| 6| 7| 5| 7| 7| 6| 5| 7| 6| 6| 5| 6| 2| 0| 3| 7| 6|             
                             DAY ON TEST   | 2| 5| 2| 5| 3| 5| 6| 3| 5| 2| 4| 2| 2| 4| 3| 1| 1| 1| 9| 8| 4| 4| 2| 2| 4|             
                                           | 7| 4| 7| 9| 1| 8| 3| 1| 9| 9| 6| 7| 9| 5| 1| 5| 8| 8| 9| 8| 7| 0| 8| 2| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    300                                    | 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|             
    NG/KG                                  | 5| 1| 3| 4| 9| 1| 2| 3| 5| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Necrosis                             |                                                                         2|             
      Pigmentation                         |                                                    2                     |             
      Pars Distalis, Hyperplasia           | 2  2     1                       1  2  2        1  2                 3  3|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    2           1     1  3                 2  3     1     1               |             
      Follicular Cell, Hypertrophy         | 2  2  1  1  3           1  1  3  1  2                       2     1  2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |    1  2  2  1        1                       1  2  1                    1|             
      Duct, Cyst                           | 1  2  3  2     1     1     2     2     2  2  3  2  2  3  1  2     1  2   |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4     4  4  4  4  4  4  4     4  4  4  4  4  4  4  4     4  4     4  4  4|             
      Cyst                                 | 3        2  2              1        2     2  3     2  2                 2|             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis                             |                                                                          |             
                                           |__________________________________________________________________________|             
   Oviduct                                 |                                                                      +   |             
      Inflammation, Chronic Active         |                                                                      3   |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                        3                                 |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |       2     3                    1           2  1                        |             
      Metaplasia, Squamous                 | 1  1  4              1  2     2  1  2     2  3        3  1  2     1  3  2|             
      Cervix, Cyst                         |             2                                                            |             
      Endometrium, Hyperplasia, Cystic     | 2        1     2        2     3  3  1  1                 1              2|             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  98                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 3| 6| 1| 5| 6| 7| 5| 7| 7| 6| 5| 7| 6| 6| 5| 6| 2| 0| 3| 7| 6|             
                             DAY ON TEST   | 2| 5| 2| 5| 3| 5| 6| 3| 5| 2| 4| 2| 2| 4| 3| 1| 1| 1| 9| 8| 4| 4| 2| 2| 4|             
                                           | 7| 4| 7| 9| 1| 8| 3| 1| 9| 9| 6| 7| 9| 5| 1| 5| 8| 8| 9| 8| 7| 0| 8| 2| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    300                                    | 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|             
    NG/KG                                  | 5| 1| 3| 4| 9| 1| 2| 3| 5| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2  4     3  4  3  3     4  4  2        3     3  4  4  4     4  4  4  3  3|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |             +                                      +                     |             
      Lumbar, Hyperplasia, Plasma Cell     |             3                                                            |             
      Mediastinal, Hemorrhage              |                                                    2                     |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                    2                     |             
      Mediastinal, Inflammation,           |                                                                          |             
          Suppurative                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                  2  2                                2   |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                             2            |             
      Hyperplasia, Plasma Cell             | 3     2        2  1        3        2  2  2     2  2              1      |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 1  2  1  1  2  2        1  1     1  1        2     2  3  1  1  3  2  2  3|             
      Hyperplasia, Lymphoid                |          2                                                               |             
      Pigmentation                         | 2  1  2     2  1  1  1  2  1  1  2  2  2  2  2  2  1  1  2  1  1  1  2  1|             
      Lymphoid Follicle, Atrophy           |                   2                    2        2                        |             
      Red Pulp, Atrophy                    |                                                 2                        |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  M  +  +  M  +  +  +  +  +  M  M  +  +  +  M  +  +|             
      Atrophy                              | 3  3  4  4     3           3  2     4  4  2  4  4        4           3  4|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                  3        2                              |             
      Fibrosis, Focal                      |                                                                          |             
      Hyperplasia                          |                1        1           1     2        1     1              1|             
      Inflammation, Chronic Active         |                                  2                                       |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  99                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 3| 6| 1| 5| 6| 7| 5| 7| 7| 6| 5| 7| 6| 6| 5| 6| 2| 0| 3| 7| 6|             
                             DAY ON TEST   | 2| 5| 2| 5| 3| 5| 6| 3| 5| 2| 4| 2| 2| 4| 3| 1| 1| 1| 9| 8| 4| 4| 2| 2| 4|             
                                           | 7| 4| 7| 9| 1| 8| 3| 1| 9| 9| 6| 7| 9| 5| 1| 5| 8| 8| 9| 8| 7| 0| 8| 2| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    300                                    | 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|             
    NG/KG                                  | 5| 1| 3| 4| 9| 1| 2| 3| 5| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                                           2                    2         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                   2                                                      |             
      Infiltration Cellular, Histiocyte    | 2  1  2  2     1     1  1  2  1  2  1  2  2  1  1  1  2  2           2  2|             
      Inflammation, Chronic Active         |                                                                2         |             
      Metaplasia, Squamous                 | 2                                                     3                  |             
      Alveolar Epithelium, Hyperplasia     |                         1                                                |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     | 3  1  2  2     2           1  1  3  1  2  1  1  1  2  3  2              2|             
      Serosa, Inflammation, Suppurative    |                   3                                                      |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation      |                                                                          |             
      Nasolacrimal Duct, Respiratory       |                                                                          |             
          Epithelium, Hyperplasia          |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |                                                                          |             
      Respiratory Epithelium, Inflammation,|                                                                          |             
           Suppurative                     |                                                                          |             
      Respiratory Epithelium, Metaplasia   |                                                                          |             
      Turbinate, Inflammation, Suppurative |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 100                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 3| 6| 1| 5| 6| 7| 5| 7| 7| 6| 5| 7| 6| 6| 5| 6| 2| 0| 3| 7| 6|             
                             DAY ON TEST   | 2| 5| 2| 5| 3| 5| 6| 3| 5| 2| 4| 2| 2| 4| 3| 1| 1| 1| 9| 8| 4| 4| 2| 2| 4|             
                                           | 7| 4| 7| 9| 1| 8| 3| 1| 9| 9| 6| 7| 9| 5| 1| 5| 8| 8| 9| 8| 7| 0| 8| 2| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    300                                    | 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8|             
    NG/KG                                  | 5| 1| 3| 4| 9| 1| 2| 3| 5| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
   Ear                                     |                                                                          |             
      Inflammation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cataract                             |                                                                          |             
      Edema                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                      1   |             
                                           |__________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                         1                                                |             
      Mineralization                       | 1  1  1  1     1  1  2  1  1  1  1  1     1     1  1  1     1  1  1  1  1|             
      Necrosis                             |                                                       3                  |             
      Nephropathy                          | 2     2     1  1     1     1     2  1  2  2  2     3  1  2           1  1|             
      Papilla, Angiectasis                 |                                                                          |             
      Pelvis, Inflammation, Suppurative    |    2                                            2                        |             
      Transitional Epithelium, Hyperplasia |    2  1                                         2                        |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |    2                       1                                             |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 101                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7|                                                                 |            |
                             DAY ON TEST   | 2| 5| 2|                                                                 |            |
                                           | 2| 4| 7|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 5| 5| 5|                                                                 |      A     |
    300                                    | 9| 9| 9|                                                                 |      L     |
    NG/KG                                  | 0| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  53        |
      Muscularis, Degeneration             |                                                                          |      1  2.0|
      Muscularis, Inflammation             |                                                                          |      1  1.0|
      Periesophageal Tissue, Inflammation, |                                                                          |            |
           Suppurative                     |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  53        |
      Parasite Metazoan                    |                                                                          |      1     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  53        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  53        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |      1  2.0|
      Basophilic Focus                     |                                                                          |      2     |
      Basophilic Focus, Multiple           |                                                                          |      2     |
      Cholangiofibrosis                    |                                                                          |      3  1.7|
      Cytoplasmic Alteration               |                                                                          |      1  2.0|
      Degeneration, Cystic                 |                                                                          |      1  1.0|
      Eosinophilic Focus                   |                                                                          |      2     |
      Eosinophilic Focus, Multiple         | X                                                                        |     15     |
      Fatty Change, Diffuse                |    1  1                                                                  |     30  1.1|
      Fatty Change, Focal                  |                                                                          |      3  1.7|
      Hepatocyte, Multinucleate            |                                                                          |     19  1.3|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 102                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7|                                                                 |            |
                             DAY ON TEST   | 2| 5| 2|                                                                 |            |
                                           | 2| 4| 7|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 5| 5| 5|                                                                 |      A     |
    300                                    | 9| 9| 9|                                                                 |      L     |
    NG/KG                                  | 0| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Hyperplasia, Nodular                 |                                                                          |      3     |
      Inflammation                         | 1  1  1                                                                  |     51  1.2|
      Mixed Cell Focus, Multiple           | X  X  X                                                                  |     30     |
      Necrosis                             |                                                                          |     11  1.9|
      Pigmentation                         | 2  1  2                                                                  |     48  1.9|
      Toxic Hepatopathy                    | 1  1  1                                                                  |     39  1.3|
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
      Bile Duct, Cyst                      |                                                                          |      3  2.7|
      Bile Duct, Fibrosis                  |                                                                          |      1  1.0|
      Bile Duct, Hyperplasia               |    1                                                                     |     14  1.2|
      Hepatocyte, Degeneration             |                                                                          |      1  1.0|
      Hepatocyte, Hypertrophy              | 1  1  1                                                                  |     42  1.4|
      Oval Cell, Hyperplasia               |       1                                                                  |     10  1.2|
      Portal, Fibrosis                     |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |       +                                                                  |   7        |
      Artery, Inflammation, Chronic Active |       3                                                                  |      6  3.2|
      Fat, Necrosis                        |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   2        |
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  53        |
      Inflammation, Chronic Active         | 1                                                                        |      4  1.8|
      Acinus, Atrophy                      |                                                                          |      2  2.5|
      Acinus, Hyperplasia                  |                                                                          |      1  2.0|
      Acinus, Vacuolization Cytoplasmic    | 1                                                                        |      9  1.0|
      Artery, Inflammation, Chronic Active |       3                                                                  |      8  2.5|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  52        |
      Atrophy                              |                                                                          |      1  2.0|
      Cyst                                 |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 103                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7|                                                                 |            |
                             DAY ON TEST   | 2| 5| 2|                                                                 |            |
                                           | 2| 4| 7|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 5| 5| 5|                                                                 |      A     |
    300                                    | 9| 9| 9|                                                                 |      L     |
    NG/KG                                  | 0| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
   Stomach, Forestomach                    | +  +  +                                                                  |  53        |
      Edema                                |                                                                          |      1  2.0|
      Hyperkeratosis                       |                                                                          |      3  1.7|
      Hyperplasia, Squamous                |                                                                          |      5  1.8|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      3  2.3|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Tooth                                   |       +                                                                  |  10        |
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Suppurative                     |       1                                                                  |     10  1.4|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  53        |
      Cardiomyopathy                       | 1     1                                                                  |     24  1.1|
      Epicardium, Inflammation, Chronic    |                                                                          |            |
          Active                           |                                                                          |      1  3.0|
      Myocardium, Inflammation             |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
      Angiectasis                          | 1  2  2                                                                  |     20  1.5|
      Atrophy                              |                                                                          |      5  1.6|
      Degeneration, Cystic                 | 1                                                                        |     14  2.1|
      Hyperplasia                          | 3  3  2                                                                  |     25  2.4|
      Hypertrophy                          | 2  1                                                                     |     40  1.9|
      Necrosis                             |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |       2                                                                  |      9  1.9|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 104                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7|                                                                 |            |
                             DAY ON TEST   | 2| 5| 2|                                                                 |            |
                                           | 2| 4| 7|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 5| 5| 5|                                                                 |      A     |
    300                                    | 9| 9| 9|                                                                 |      L     |
    NG/KG                                  | 0| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Adrenal Medulla                         | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |      2  2.5|
      Hyperplasia                          | 2     1                                                                  |     12  1.8|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +                                                                  |  49        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  53        |
      Angiectasis                          |       2                                                                  |     16  2.3|
      Cytoplasmic Alteration               |                                                                          |      3  2.0|
      Necrosis                             |                                                                          |      1  2.0|
      Pigmentation                         |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia           | 2                                                                        |     21  1.9|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  52        |
      C-Cell, Hyperplasia                  | 2                                                                        |     18  1.9|
      Follicular Cell, Hypertrophy         | 1  2                                                                     |     28  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +                                                                  |  53        |
      Inflammation                         |    1  2                                                                  |     30  1.4|
      Duct, Cyst                           | 3     3                                                                  |     39  2.0|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  52        |
      Atrophy                              | 4  4  4                                                                  |     47  4.0|
      Cyst                                 |                                                                          |     16  2.1|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 105                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7|                                                                 |            |
                             DAY ON TEST   | 2| 5| 2|                                                                 |            |
                                           | 2| 4| 7|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 5| 5| 5|                                                                 |      A     |
    300                                    | 9| 9| 9|                                                                 |      L     |
    NG/KG                                  | 0| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |   1        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +                                                                  |  53        |
      Hemorrhage                           |                                                                          |      2  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Inflammation, Suppurative            | 1                                                                        |     10  1.6|
      Metaplasia, Squamous                 |       1                                                                  |     29  1.8|
      Cervix, Cyst                         |                                                                          |      1  2.0|
      Endometrium, Hyperplasia, Cystic     | 2                                                                        |     26  2.0|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
      Hyperplasia                          | 4  3  2                                                                  |     45  3.2|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   4        |
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |      1  3.0|
      Mediastinal, Hemorrhage              |                                                                          |      1  2.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  3.0|
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |      1  2.0|
      Mediastinal, Inflammation,           |                                                                          |            |
          Suppurative                      |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  52        |
      Ectasia                              |                                                                          |      4  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
      Hyperplasia, Plasma Cell             | 2     2                                                                  |     29  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 106                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7|                                                                 |            |
                             DAY ON TEST   | 2| 5| 2|                                                                 |            |
                                           | 2| 4| 7|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 5| 5| 5|                                                                 |      A     |
    300                                    | 9| 9| 9|                                                                 |      L     |
    NG/KG                                  | 0| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  53        |
      Hematopoietic Cell Proliferation     | 3  1  1                                                                  |     41  1.7|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Pigmentation                         | 1  1  2                                                                  |     52  1.5|
      Lymphoid Follicle, Atrophy           |                                                                          |      5  2.0|
      Red Pulp, Atrophy                    |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | M  +  +                                                                  |  41        |
      Atrophy                              |    3  2                                                                  |     36  3.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  53        |
      Cyst                                 |                                                                          |      5  2.6|
      Fibrosis, Focal                      |                                                                          |      1  2.0|
      Hyperplasia                          | 1     1                                                                  |     21  1.2|
      Inflammation, Chronic Active         |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
      Osteopetrosis                        |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 107                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7|                                                                 |            |
                             DAY ON TEST   | 2| 5| 2|                                                                 |            |
                                           | 2| 4| 7|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 5| 5| 5|                                                                 |      A     |
    300                                    | 9| 9| 9|                                                                 |      L     |
    NG/KG                                  | 0| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
   Lung                                    | +  +  +                                                                  |  53        |
      Congestion                           |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    | 2  1  1                                                                  |     45  1.6|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Metaplasia, Squamous                 |                                                                          |      3  2.3|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  1.0|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Bronchiolar                     | 2  1  1                                                                  |     39  1.7|
      Serosa, Inflammation, Suppurative    |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  52        |
      Nasolacrimal Duct, Inflammation      |                                                                          |      1  2.0|
      Nasolacrimal Duct, Respiratory       |                                                                          |            |
          Epithelium, Hyperplasia          |                                                                          |      1  2.0|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      2  2.0|
      Respiratory Epithelium, Inflammation,|                                                                          |            |
           Suppurative                     |                                                                          |      1  2.0|
      Respiratory Epithelium, Metaplasia   |                                                                          |      1  2.0|
      Turbinate, Inflammation, Suppurative |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
      Inflammation                         |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +                                                                  |  53        |
      Cataract                             | 3                                                                        |      1  3.0|
      Edema                                | 3                                                                        |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |      3  1.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 108                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7|                                                                 |            |
                             DAY ON TEST   | 2| 5| 2|                                                                 |            |
                                           | 2| 4| 7|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 5| 5| 5|                                                                 |      A     |
    300                                    | 9| 9| 9|                                                                 |      L     |
    NG/KG                                  | 0| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
   Lacrimal Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  53        |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Mineralization                       | 1  1  1                                                                  |     44  1.0|
      Necrosis                             |                                                                          |      1  3.0|
      Nephropathy                          | 1     2                                                                  |     38  1.5|
      Papilla, Angiectasis                 | 2                                                                        |      1  2.0|
      Pelvis, Inflammation, Suppurative    |                                                                          |      3  2.0|
      Transitional Epithelium, Hyperplasia | 1                                                                        |      8  1.6|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  52        |
      Inflammation                         |                                                                          |      7  1.6|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 109                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 5| 7| 3| 7| 6| 1| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7|             
                             DAY ON TEST   | 2| 2| 1| 7| 3| 2| 2| 2| 1| 8| 2| 2| 2| 2| 6| 2| 1| 2| 5| 2| 2| 5| 3| 2| 2|             
                                           | 8| 7| 8| 3| 5| 7| 0| 8| 8| 5| 8| 8| 7| 7| 7| 2| 4| 8| 1| 8| 8| 1| 7| 2| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    550                                    | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
    NG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 9| 1| 9| 1| 2| 4| 5| 1| 2| 4| 5| 7| 8| 9| 0| 6| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Muscularis, Inflammation             |                      1                                   2               |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                             1            |             
      Basophilic Focus                     |                                                                          |             
      Basophilic Focus, Multiple           |                                                                          |             
      Cholangiofibrosis                    | 1                             3        1                 3  3  1     1   |             
      Cytoplasmic Alteration               |                                                                          |             
      Degeneration, Cystic                 |                                                                          |             
      Eosinophilic Focus                   |                X                                                         |             
      Eosinophilic Focus, Multiple         |             X           X           X     X  X        X        X  X      |             
      Fatty Change, Diffuse                | 1  2  1  1  2  2     2  1     2  2  2     1  1     1  2  1  1  1  1     1|             
      Fatty Change, Focal                  |                                                                          |             
      Hematopoietic Cell Proliferation     |    2                                                                     |             
      Hepatocyte, Multinucleate            | 2  2  1  1  1  1     2  1     1  2  2  2  3  1        1  1  1  2  1  3  2|             
      Hyperplasia, Nodular                 | X  X  X     X        X           X  X  X           X     X  X  X  X     X|             
      Inflammation                         | 2  2  1  1  2  2  1  1  1  1  1  1  2  1  2  2     1  1  2  2  1  2  2  1|             
      Mixed Cell Focus                     |                                                                          |             
      Mixed Cell Focus, Multiple           | X  X           X     X        X  X  X        X        X  X  X  X  X  X   |             
      Necrosis                             |    2     1  3  2           2        3  2  2        1                     |             
      Pigmentation                         | 3  2  2  3  3  2  1  3  2  1  3  2  3  2  3  2     2  2  3  2  3  1  3  4|             
      Toxic Hepatopathy                    | 3  3  2  2  4  3  1  3  2  1  3  4  3  3  2  2     2  1  2  2  2  2  3  3|             
      Artery, Inflammation, Chronic Active |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 110                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 5| 7| 3| 7| 6| 1| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7|             
                             DAY ON TEST   | 2| 2| 1| 7| 3| 2| 2| 2| 1| 8| 2| 2| 2| 2| 6| 2| 1| 2| 5| 2| 2| 5| 3| 2| 2|             
                                           | 8| 7| 8| 3| 5| 7| 0| 8| 8| 5| 8| 8| 7| 7| 7| 2| 4| 8| 1| 8| 8| 1| 7| 2| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    550                                    | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
    NG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 9| 1| 9| 1| 2| 4| 5| 1| 2| 4| 5| 7| 8| 9| 0| 6| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Bile Duct, Cyst                      |                               2  2  1  1                 2               |             
      Bile Duct, Fibrosis                  |    1        1                                                            |             
      Bile Duct, Hyperplasia               | 2  2  2  2  2  2     2  1     2  3  2  2     2     1  1  2  1  2  2  2  3|             
      Hepatocyte, Degeneration             |                                                                          |             
      Hepatocyte, Hypertrophy              | 3  2     3  3  2  2  2  2  2  2  2  2  3  3  3     2  1  2  2  2  2  1  3|             
      Oval Cell, Hyperplasia               | 2  2     2  2  2     2        2  2  1  3     1           2  1  2  2  2  2|             
      Portal, Fibrosis                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               | +        +     +           +              +                       +     +|             
      Artery, Inflammation, Chronic Active | 3        3     2                          3                             3|             
      Fat, Necrosis                        |                                                                   3      |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |    +                             +                    +  +              +|             
      Gingival, Hyperplasia, Squamous      |    3                             1                    1  1               |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic Active         |          2                             3                          2      |             
      Acinus, Atrophy                      |          3                             3  2                       2     2|             
      Acinus, Vacuolization Cytoplasmic    | 1  2           1              1  2  1              1        1     1  1  1|             
      Artery, Inflammation, Chronic Active | 1  2                                   3  2              3           4  4|             
      Artery, Mineralization               |          2                                                               |             
      Duct, Hyperplasia                    |                                                                          |             
      Duct, Inflammation, Chronic Active   |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Squamous                |                   2                    1                                2|             
      Mineralization                       |          2                                                               |             
      Ulcer                                |                   2                                                      |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tooth                                   |    +     +                       +  +        +        +  +               |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic Active                  |    4                                                                     |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 111                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 5| 7| 3| 7| 6| 1| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7|             
                             DAY ON TEST   | 2| 2| 1| 7| 3| 2| 2| 2| 1| 8| 2| 2| 2| 2| 6| 2| 1| 2| 5| 2| 2| 5| 3| 2| 2|             
                                           | 8| 7| 8| 3| 5| 7| 0| 8| 8| 5| 8| 8| 7| 7| 7| 2| 4| 8| 1| 8| 8| 1| 7| 2| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    550                                    | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
    NG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 9| 1| 9| 1| 2| 4| 5| 1| 2| 4| 5| 7| 8| 9| 0| 6| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Suppurative                     |          2                       2  2        2        1  1               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |          1                                                               |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1     1        1                 1     1  1        1           1     1   |             
      Degeneration                         |          3                                                               |             
      Mineralization                       |          2                                                               |             
      Thrombosis                           |                                                                          |             
      Myocardium, Inflammation             |    1                                                                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                2     3                                   1               |             
      Atrophy                              | 1  2                          1  1     3  1  1                    1  1  2|             
      Degeneration, Cystic                 |             2                    3                          2            |             
      Hyperplasia                          | 3        2     2     3        2  3  3  3  2  3     2     3  3  3        2|             
      Hypertrophy                          | 2  1     2     3     2  2  2  2  2  2     2  1     2  4  3  3  2  2  2  2|             
      Mineralization                       |                                                                          |             
      Necrosis                             |                                                                          |             
      Thrombosis                           |                                                                          |             
      Vacuolization Cytoplasmic            |       1                             1                                    |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                        2                                 |             
      Hyperplasia                          | 2        2                    1                                      1   |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 1                                                                        |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  M  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          1                                                               |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 112                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 5| 7| 3| 7| 6| 1| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7|             
                             DAY ON TEST   | 2| 2| 1| 7| 3| 2| 2| 2| 1| 8| 2| 2| 2| 2| 6| 2| 1| 2| 5| 2| 2| 5| 3| 2| 2|             
                                           | 8| 7| 8| 3| 5| 7| 0| 8| 8| 5| 8| 8| 7| 7| 7| 2| 4| 8| 1| 8| 8| 1| 7| 2| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    550                                    | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
    NG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 9| 1| 9| 1| 2| 4| 5| 1| 2| 4| 5| 7| 8| 9| 0| 6| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       3              2        3  2  1  2           3     1     2     2  3|             
      Cyst                                 |                                                          2               |             
      Cytoplasmic Alteration               |                                                                          |             
      Inflammation, Focal, Granulomatous   |                                                                          |             
      Pars Distalis, Hyperplasia           |    1           3     2        3     3  3     2        2  2  3  2  2      |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      C-Cell, Hyperplasia                  | 1              3     2        2                       1  2  2  2         |             
      Follicular Cell, Hypertrophy         | 1  1     2     1  1     1     2     2              1  1  1               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Inflammation                         |          1  2     1     1     1        1           1              2  2   |             
      Duct, Cyst                           |          1  3     2     2     2  3  1  4  2  2     1  3  3  3  2  3  2  2|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4  4  4  4  4  4  4  4        4  4  4  4  4     4  4  4  4     4  4   |             
      Cyst                                 |          2              2     2     3                          2  2     2|             
      Inflammation, Suppurative            |                                     2                                    |             
                                           |__________________________________________________________________________|             
   Oviduct                                 |                                     +                          +         |             
      Cyst                                 |                                                                4         |             
      Inflammation, Suppurative            |                                     2                                    |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Adenomyosis                          | 3                       2                                                |             
      Hemorrhage                           |             3                                                            |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |    1  3     2                       2                                    |             
      Metaplasia, Squamous                 | 2     3  3           2  1     3           3  1           2     4  2      |             
      Thrombosis                           |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 113                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 5| 7| 3| 7| 6| 1| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7|             
                             DAY ON TEST   | 2| 2| 1| 7| 3| 2| 2| 2| 1| 8| 2| 2| 2| 2| 6| 2| 1| 2| 5| 2| 2| 5| 3| 2| 2|             
                                           | 8| 7| 8| 3| 5| 7| 0| 8| 8| 5| 8| 8| 7| 7| 7| 2| 4| 8| 1| 8| 8| 1| 7| 2| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    550                                    | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
    NG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 9| 1| 9| 1| 2| 4| 5| 1| 2| 4| 5| 7| 8| 9| 0| 6| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Artery, Inflammation, Chronic Active | 3                                                                        |             
      Cervix, Hyperplasia, Stromal         |    3                                                                     |             
      Endometrium, Hyperplasia, Cystic     | 2  3           3     3  3           3  2           1     2  2     3     1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia                          | 3  4  4  4  3  3  3  2  4  4     3  2     3  3  3  3  2     3  4  3     3|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |          +              +              +                       +         |             
      Lumbar, Ectasia                      |                                                                2         |             
      Lumbar, Hyperplasia                  |                         2                                                |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
      Pancreatic, Hyperplasia, Plasma Cell |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                              3           2               |             
      Hyperplasia, Plasma Cell             |                   2  2  2                                               2|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                2         |             
      Hyperplasia, Histiocytic             |                                                                         2|             
      Pigmentation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 1  2  1  2     1  2  1  1     1  2     1  1  1           1  1  2  2      |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation                         | 2  1  2  2  2  2  1  2  1  1  2  1  2  2  2  2     2  1  1  1  1  1  2  1|             
      Lymphoid Follicle, Atrophy           |       2                                                                  |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4  3  4     4     4  3  3  4  4  3  2  4  4     3  3  4  3  4  3  4  2|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                    2                     |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 114                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 5| 7| 3| 7| 6| 1| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7|             
                             DAY ON TEST   | 2| 2| 1| 7| 3| 2| 2| 2| 1| 8| 2| 2| 2| 2| 6| 2| 1| 2| 5| 2| 2| 5| 3| 2| 2|             
                                           | 8| 7| 8| 3| 5| 7| 0| 8| 8| 5| 8| 8| 7| 7| 7| 2| 4| 8| 1| 8| 8| 1| 7| 2| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    550                                    | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
    NG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 9| 1| 9| 1| 2| 4| 5| 1| 2| 4| 5| 7| 8| 9| 0| 6| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
      Hyperplasia                          | 2        1           1  1  2     1  2        1     1     1     1     1  1|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cartilage, Hypertrophy, Focal        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 2  2  1  1     2  1  2  1     2  2  2  2  2  2     1  2  2  2  1  2  2  1|             
      Inflammation, Suppurative            |                                                                          |             
      Metaplasia, Squamous                 |          1                                            2     2        2   |             
      Mineralization                       |          2                                                               |             
      Thrombosis                           |          2                                                               |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     | 3  2  1  2     2  1  3  2     3  2  3  2  3  3     1  2  2  2  2  3  3  2|             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Glands,           |                                                                          |             
          Hyperplasia                      |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |                                                                         3|             
      Respiratory Epithelium, Inflammation,|                                                                          |             
           Suppurative                     |                                                                          |             
      Turbinate, Cyst                      |                                  1                                       |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 115                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 5| 7| 3| 7| 6| 1| 7| 7| 7| 7| 6| 7| 6| 6| 6| 7| 7| 6| 6| 7| 7|             
                             DAY ON TEST   | 2| 2| 1| 7| 3| 2| 2| 2| 1| 8| 2| 2| 2| 2| 6| 2| 1| 2| 5| 2| 2| 5| 3| 2| 2|             
                                           | 8| 7| 8| 3| 5| 7| 0| 8| 8| 5| 8| 8| 7| 7| 7| 2| 4| 8| 1| 8| 8| 1| 7| 2| 0|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    550                                    | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|             
    NG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 9| 1| 9| 1| 2| 4| 5| 1| 2| 4| 5| 7| 8| 9| 0| 6| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
   Eye                                     | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cataract                             |                                                                3         |             
      Anterior Chamber, Inflammation,      |                                                                          |             
          Suppurative                      |                                                                         3|             
      Cornea, Inflammation, Suppurative    |                                                                         3|             
      Retina, Atrophy                      |                                              3                           |             
      Retina, Degeneration                 |                                                                2         |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                    1                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |       X                                                                  |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |       3                                                                  |             
      Mineralization                       | 1  1     3  1  1  1  1  1     1  2  1  1  1  1     1  1     1  1  1  2   |             
      Necrosis                             |       3                                                                  |             
      Nephropathy                          | 3  2     3     3     2  2     2  3  2  2  3  1     2     2  2  1  2  2  3|             
      Pelvis, Dilatation                   |       2                                                                  |             
      Transitional Epithelium, Hyperplasia |       2                          2                    2        2     3   |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Inflammation                         |       1  1                       1                                       |             
      Transitional Epithelium, Hyperplasia |       3                                                                  |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 116                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 6| 5| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 3| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 2| 7| 7| 2| 5| 2| 2| 7| 9| 2| 2| 1| 1| 2| 2| 2| 0| 0| 1| 4| 2| 1| 2| 2|             
                                           | 8| 7| 8| 4| 8| 4| 8| 9| 8| 9| 8| 7| 8| 4| 7| 8| 7| 0| 2| 4| 0| 7| 2| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    550                                    | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|             
    NG/KG                                  | 0| 1| 2| 3| 5| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 1| 3| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                         3                                                |             
      Muscularis, Inflammation             |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                              2                           |             
      Basophilic Focus                     |                      X        X                          X               |             
      Basophilic Focus, Multiple           |    X                                                                     |             
      Cholangiofibrosis                    |    2                             1           1  2              2  2      |             
      Cytoplasmic Alteration               |                   2                                                      |             
      Degeneration, Cystic                 |                                              2                           |             
      Eosinophilic Focus                   |                      X                 X                                 |             
      Eosinophilic Focus, Multiple         | X        X  X  X        X        X  X                 X  X  X        X  X|             
      Fatty Change, Diffuse                | 1  2  2  2  1  1  1  1  1  2  2  2  1  2     2  2     1  1  1  1  2  1  2|             
      Fatty Change, Focal                  |                                                             1            |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatocyte, Multinucleate            |    2  2     1  1  2  1  1  1  1  1  2  2     1  1  1  2  2  2  2  1  1  2|             
      Hyperplasia, Nodular                 |    X        X        X     X  X  X           X  X  X           X        X|             
      Inflammation                         | 1  1  1  1  1  2  1  1  1  2  1  1  2  2     2  1  2  1  1  1  1  2  2  1|             
      Mixed Cell Focus                     |                                                          X           X   |             
      Mixed Cell Focus, Multiple           |          X  X     X        X  X  X           X  X              X  X     X|             
      Necrosis                             |       2                    3           2     1                       2   |             
      Pigmentation                         | 2  2  3  2  2  2  2  2  3  2  2  2  2  3     2  2  3  2  2  1  3  2  2  2|             
      Toxic Hepatopathy                    | 1  3  3  1  2  2  2  2  2  3  3  3  2  3     3  3  2  2  2  1  3  2  3  2|             
      Artery, Inflammation, Chronic Active |                                                                      2   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 117                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 6| 5| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 3| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 2| 7| 7| 2| 5| 2| 2| 7| 9| 2| 2| 1| 1| 2| 2| 2| 0| 0| 1| 4| 2| 1| 2| 2|             
                                           | 8| 7| 8| 4| 8| 4| 8| 9| 8| 9| 8| 7| 8| 4| 7| 8| 7| 0| 2| 4| 0| 7| 2| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    550                                    | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|             
    NG/KG                                  | 0| 1| 2| 3| 5| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 1| 3| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Bile Duct, Cyst                      |                               4              2                           |             
      Bile Duct, Fibrosis                  |                                                       1           1      |             
      Bile Duct, Hyperplasia               |    2  3  1  1  1  1  2  1  2  2  2  2  2     2  1  2  1  1     1  2  4  1|             
      Hepatocyte, Degeneration             |                         1                                                |             
      Hepatocyte, Hypertrophy              | 2  2  4  1  2  1  2  2  3  2  2  2  2  3     4  1  2  2  3  2  3  3  3  3|             
      Oval Cell, Hyperplasia               |    2  2     1     2  2  1  1  2  2  1  3     2  2  2     1     2  1  1  1|             
      Portal, Fibrosis                     |                            1                                             |             
                                           |__________________________________________________________________________|             
   Mesentery                               |       +                                            +  +  +     +         |             
      Artery, Inflammation, Chronic Active |                                                    2  2  3     3         |             
      Fat, Necrosis                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +                                                                        |             
      Gingival, Hyperplasia, Squamous      |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic Active         |       3                                                  2               |             
      Acinus, Atrophy                      |       3                 2                                3        1  1   |             
      Acinus, Vacuolization Cytoplasmic    |    1              1           1  1  1           1     1        1        1|             
      Artery, Inflammation, Chronic Active |       2           2                          3        2  2     3     3   |             
      Artery, Mineralization               |                                                                          |             
      Duct, Hyperplasia                    |       4                                                                  |             
      Duct, Inflammation, Chronic Active   |       3                                                                  |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |       2                                                                  |             
      Hyperplasia, Squamous                |       2                                                  2               |             
      Mineralization                       |                                                                          |             
      Ulcer                                |       2                                                                  |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 118                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 6| 5| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 3| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 2| 7| 7| 2| 5| 2| 2| 7| 9| 2| 2| 1| 1| 2| 2| 2| 0| 0| 1| 4| 2| 1| 2| 2|             
                                           | 8| 7| 8| 4| 8| 4| 8| 9| 8| 9| 8| 7| 8| 4| 7| 8| 7| 0| 2| 4| 0| 7| 2| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    550                                    | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|             
    NG/KG                                  | 0| 1| 2| 3| 5| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 1| 3| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |       1                                                                  |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    1  1  1     1  1     1     1  1  1  1     2  1  1  1  1     1  2  1   |             
      Degeneration                         |                                                                          |             
      Mineralization                       |                                                                          |             
      Thrombosis                           |                                                 2                        |             
      Myocardium, Inflammation             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    1     1                                                  1  1        1|             
      Atrophy                              |          3     2           1  1  3           3        3  3           1   |             
      Degeneration, Cystic                 |       2  2     3        2     1  3           1  2     3  3        2      |             
      Hyperplasia                          |    3  1  2        2     2  2  3  4              3     4  3     4  3     3|             
      Hypertrophy                          |    2  2     1  1  2  2     2  3  2  1  2     4  1  3           2  1  1  1|             
      Mineralization                       |                                                                          |             
      Necrosis                             |                                        2                                 |             
      Thrombosis                           |                                                             2            |             
      Vacuolization Cytoplasmic            |                1                       1                                 |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |             3                                                            |             
      Hyperplasia                          |                                                 2  4                     |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 119                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 6| 5| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 3| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 2| 7| 7| 2| 5| 2| 2| 7| 9| 2| 2| 1| 1| 2| 2| 2| 0| 0| 1| 4| 2| 1| 2| 2|             
                                           | 8| 7| 8| 4| 8| 4| 8| 9| 8| 9| 8| 7| 8| 4| 7| 8| 7| 0| 2| 4| 0| 7| 2| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    550                                    | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|             
    NG/KG                                  | 0| 1| 2| 3| 5| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 1| 3| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    2                                2        3                 2     3  3|             
      Cyst                                 |                                                                          |             
      Cytoplasmic Alteration               |                                                                          |             
      Inflammation, Focal, Granulomatous   |                                              2                           |             
      Pars Distalis, Hyperplasia           |    3  1     2        2  3     2  2     3        2        2     2     2  2|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                          2               |             
      C-Cell, Hyperplasia                  |       2     2  2  2           1              3                           |             
      Follicular Cell, Hypertrophy         | 1  2        3  1  1        1  1  1           2  2  1           2  1     1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1  1  1           2  1  1     1     1  2     2     1  1     1  1  2  2   |             
      Duct, Cyst                           | 2  3  3  2  1     3     3  2  1  3  1  3     3  3  3  2  2  1  2  3  2  2|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4     4  4  4     4  4|             
      Cyst                                 | 2                             2  2  1  2     3           2     2        2|             
      Inflammation, Suppurative            |             3                                                            |             
                                           |__________________________________________________________________________|             
   Oviduct                                 |             +                                                            |             
      Cyst                                 |                                                                          |             
      Inflammation, Suppurative            |             3                                                            |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomyosis                          |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         |                                        2                                 |             
      Inflammation, Suppurative            |                      3                                                   |             
      Metaplasia, Squamous                 | 1  3     2  1     2  3     2  2     1  3     3           3  1           1|             
      Thrombosis                           |                                        3                                 |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 120                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 6| 5| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 3| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 2| 7| 7| 2| 5| 2| 2| 7| 9| 2| 2| 1| 1| 2| 2| 2| 0| 0| 1| 4| 2| 1| 2| 2|             
                                           | 8| 7| 8| 4| 8| 4| 8| 9| 8| 9| 8| 7| 8| 4| 7| 8| 7| 0| 2| 4| 0| 7| 2| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    550                                    | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|             
    NG/KG                                  | 0| 1| 2| 3| 5| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 1| 3| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Cervix, Hyperplasia, Stromal         |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |    2  1     3  2  1  2     1  2  3     4  4  2  4  1           2     1  3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                 2                        |             
      Hyperplasia                          |    3  3  3  3  4     2  4  2  3  2  3  4  4     3  4  4  4  4  3  3  2  2|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                                    +     +               |             
      Lumbar, Ectasia                      |                                                    2                     |             
      Lumbar, Hyperplasia                  |                                                                          |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                    3                     |             
      Pancreatic, Hyperplasia, Plasma Cell |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                               3                                          |             
      Hyperplasia, Plasma Cell             |                            2        2  3     2                 2        3|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Pigmentation                         |                                     1                                    |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    1     1  1  1  1  1  2  1  2  1  1  3     1  2  3  2  3  1  1  1  2  1|             
      Hyperplasia, Lymphoid                |                                  3                                       |             
      Pigmentation                         | 2  1  2  2  2  1  2  1  1  1  2  2  2  1  1  2  2  1  1  1  1  2  2  1  1|             
      Lymphoid Follicle, Atrophy           |       2                                                     3            |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Atrophy                              | 3  3  4  3  4  3  4  3  3  3  4  4  3  3     3     4  3  4     4  3  4  4|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 121                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 6| 5| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 3| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 2| 7| 7| 2| 5| 2| 2| 7| 9| 2| 2| 1| 1| 2| 2| 2| 0| 0| 1| 4| 2| 1| 2| 2|             
                                           | 8| 7| 8| 4| 8| 4| 8| 9| 8| 9| 8| 7| 8| 4| 7| 8| 7| 0| 2| 4| 0| 7| 2| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    550                                    | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|             
    NG/KG                                  | 0| 1| 2| 3| 5| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 1| 3| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
      Hyperplasia                          |    1  1     1              1        1           1              1  1     1|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cartilage, Hypertrophy, Focal        |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                   3      |             
      Hydrocephalus                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 1  2  1  3  2  1  2  2  2  2  2  2  2  2     2  2  2  2  1  1  2  2  2  1|             
      Inflammation, Suppurative            |          2                                                               |             
      Metaplasia, Squamous                 |          2              2  1                          1                 2|             
      Mineralization                       |                                                                          |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     |    3     2  3  1  2  1  3  3  2  2  2  2     2  3  3  1  1  1  2  2  3  1|             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Glands,           |                                                                          |             
          Hyperplasia                      |                               4                                          |             
      Respiratory Epithelium, Hyperplasia  |                                                                2         |             
      Respiratory Epithelium, Inflammation,|                                                                          |             
           Suppurative                     |                                                                3         |             
      Turbinate, Cyst                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 122                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 6| 5| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 3| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 2| 7| 7| 2| 5| 2| 2| 7| 9| 2| 2| 1| 1| 2| 2| 2| 0| 0| 1| 4| 2| 1| 2| 2|             
                                           | 8| 7| 8| 4| 8| 4| 8| 9| 8| 9| 8| 7| 8| 4| 7| 8| 7| 0| 2| 4| 0| 7| 2| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    550                                    | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|             
    NG/KG                                  | 0| 1| 2| 3| 5| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 1| 3| 4| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cataract                             |                                                                          |             
      Anterior Chamber, Inflammation,      |                                                                          |             
          Suppurative                      |                                                                          |             
      Cornea, Inflammation, Suppurative    |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |          1                       1                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                                          |             
      Inflammation, Chronic Active         |                               2                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |       1           1  1     1  1  1  1  1     1  1        1  1  1  2  1  1|             
      Necrosis                             |                                                                          |             
      Nephropathy                          |    3  3  1  1  1  1     3  2  1  2     2     2  2  3  3  3     2  3  2  1|             
      Pelvis, Dilatation                   |                                                                          |             
      Transitional Epithelium, Hyperplasia |                               1              2                           |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                          1               |             
      Transitional Epithelium, Hyperplasia |                                              2                           |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 123                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5|                                                                 |            |
                             DAY ON TEST   | 2| 2| 8|                                                                 |            |
                                           | 7| 9| 8|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 6| 6| 6|                                                                 |      A     |
    550                                    | 8| 9| 9|                                                                 |      L     |
    NG/KG                                  | 9| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  52        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Muscularis, Inflammation             |                                                                          |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  51        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  51        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  51        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  51        |
      Angiectasis                          |                                                                          |      2  1.5|
      Basophilic Focus                     |                                                                          |      3     |
      Basophilic Focus, Multiple           | X                                                                        |      2     |
      Cholangiofibrosis                    |                                                                          |     13  1.8|
      Cytoplasmic Alteration               |                                                                          |      1  2.0|
      Degeneration, Cystic                 |                                                                          |      1  2.0|
      Eosinophilic Focus                   |                                                                          |      3     |
      Eosinophilic Focus, Multiple         |       X                                                                  |     21     |
      Fatty Change, Diffuse                |    1  1                                                                  |     45  1.4|
      Fatty Change, Focal                  | 1                                                                        |      2  1.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hepatocyte, Multinucleate            | 1  1  1                                                                  |     46  1.5|
      Hyperplasia, Nodular                 | X                                                                        |     26     |
      Inflammation                         | 1  1  1                                                                  |     51  1.4|
      Mixed Cell Focus                     |       X                                                                  |      3     |
      Mixed Cell Focus, Multiple           |    X                                                                     |     26     |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 124                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5|                                                                 |            |
                             DAY ON TEST   | 2| 2| 8|                                                                 |            |
                                           | 7| 9| 8|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 6| 6| 6|                                                                 |      A     |
    550                                    | 8| 9| 9|                                                                 |      L     |
    NG/KG                                  | 9| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Necrosis                             |       2                                                                  |     15  2.0|
      Pigmentation                         | 2  2  2                                                                  |     51  2.3|
      Toxic Hepatopathy                    | 3  2  3                                                                  |     51  2.4|
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
      Bile Duct, Cyst                      | 2                                                                        |      8  2.0|
      Bile Duct, Fibrosis                  |                                                                          |      4  1.0|
      Bile Duct, Hyperplasia               | 2     4                                                                  |     45  1.8|
      Hepatocyte, Degeneration             |                                                                          |      1  1.0|
      Hepatocyte, Hypertrophy              | 3  2  3                                                                  |     50  2.3|
      Oval Cell, Hyperplasia               | 3  1                                                                     |     38  1.8|
      Portal, Fibrosis                     |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |       +                                                                  |  13        |
      Artery, Inflammation, Chronic Active |       2                                                                  |     10  2.6|
      Fat, Necrosis                        |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   6        |
      Gingival, Hyperplasia, Squamous      |                                                                          |      4  1.5|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  52        |
      Cyst                                 | 2                                                                        |      1  2.0|
      Inflammation, Chronic Active         |       2                                                                  |      6  2.3|
      Acinus, Atrophy                      |       2                                                                  |     11  2.2|
      Acinus, Vacuolization Cytoplasmic    |                                                                          |     20  1.1|
      Artery, Inflammation, Chronic Active |       2                                                                  |     15  2.5|
      Artery, Mineralization               |                                                                          |      1  2.0|
      Duct, Hyperplasia                    |                                                                          |      1  4.0|
      Duct, Inflammation, Chronic Active   | 3                                                                        |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  51        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  51        |
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Hyperplasia, Squamous                | 1                                                                        |      6  1.7|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 125                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5|                                                                 |            |
                             DAY ON TEST   | 2| 2| 8|                                                                 |            |
                                           | 7| 9| 8|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 6| 6| 6|                                                                 |      A     |
    550                                    | 8| 9| 9|                                                                 |      L     |
    NG/KG                                  | 9| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Mineralization                       |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  51        |
                                           |__________________________________________________________________________|____________|
   Tooth                                   | +  +                                                                     |   9        |
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                                                          |      1  4.0|
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Suppurative                     | 2  2                                                                     |      8  1.8|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +                                                                  |  53        |
      Aorta, Mineralization                |                                                                          |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  51        |
      Cardiomyopathy                       |       1                                                                  |     28  1.1|
      Degeneration                         |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      1  2.0|
      Thrombosis                           |                                                                          |      1  2.0|
      Myocardium, Inflammation             |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  52        |
      Angiectasis                          |                                                                          |      8  1.4|
      Atrophy                              |                                                                          |     19  1.8|
      Degeneration, Cystic                 | 3  2                                                                     |     16  2.3|
      Hyperplasia                          | 3  3                                                                     |     31  2.7|
      Hypertrophy                          | 2  3  2                                                                  |     41  2.0|
      Mineralization                       |       1                                                                  |      1  1.0|
      Necrosis                             |                                                                          |      1  2.0|
      Thrombosis                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 126                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5|                                                                 |            |
                             DAY ON TEST   | 2| 2| 8|                                                                 |            |
                                           | 7| 9| 8|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 6| 6| 6|                                                                 |      A     |
    550                                    | 8| 9| 9|                                                                 |      L     |
    NG/KG                                  | 9| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Vacuolization Cytoplasmic            |                                                                          |      4  1.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  52        |
      Angiectasis                          |                                                                          |      2  2.5|
      Hyperplasia                          |                                                                          |      6  2.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  52        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +                                                                  |  47        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  53        |
      Angiectasis                          |    2  2                                                                  |     19  2.3|
      Cyst                                 |       3                                                                  |      2  2.5|
      Cytoplasmic Alteration               |    2                                                                     |      1  2.0|
      Inflammation, Focal, Granulomatous   |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia           | 2                                                                        |     26  2.2|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  50        |
      Cyst                                 |                                                                          |      1  2.0|
      C-Cell, Hyperplasia                  | 1  2                                                                     |     16  1.9|
      Follicular Cell, Hypertrophy         |       1                                                                  |     26  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +                                                                  |  52        |
      Inflammation                         | 1  1                                                                     |     27  1.3|
      Duct, Cyst                           | 2  1                                                                     |     42  2.2|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 127                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5|                                                                 |            |
                             DAY ON TEST   | 2| 2| 8|                                                                 |            |
                                           | 7| 9| 8|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 6| 6| 6|                                                                 |      A     |
    550                                    | 8| 9| 9|                                                                 |      L     |
    NG/KG                                  | 9| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
   Ovary                                   | +  +  +                                                                  |  52        |
      Atrophy                              | 4  4  4                                                                  |     46  4.0|
      Cyst                                 | 2  3                                                                     |     18  2.1|
      Inflammation, Suppurative            |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |   3        |
      Cyst                                 |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +                                                                  |  52        |
      Adenomyosis                          |                                                                          |      2  2.5|
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Inflammation, Suppurative            | 2                                                                        |      6  2.2|
      Metaplasia, Squamous                 |    3  2                                                                  |     27  2.2|
      Thrombosis                           |                                                                          |      1  3.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  3.0|
      Cervix, Hyperplasia, Stromal         |                                                                          |      1  3.0|
      Endometrium, Hyperplasia, Cystic     | 2  2  1                                                                  |     32  2.2|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hyperplasia                          | 4  3  4                                                                  |     46  3.2|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              | +                                                                        |   7        |
      Lumbar, Ectasia                      |                                                                          |      2  2.0|
      Lumbar, Hyperplasia                  |                                                                          |      1  2.0|
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |      1  3.0|
      Pancreatic, Hyperplasia, Plasma Cell | 2                                                                        |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  51        |
      Ectasia                              | 2                                                                        |      4  2.5|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 128                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5|                                                                 |            |
                             DAY ON TEST   | 2| 2| 8|                                                                 |            |
                                           | 7| 9| 8|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 6| 6| 6|                                                                 |      A     |
    550                                    | 8| 9| 9|                                                                 |      L     |
    NG/KG                                  | 9| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Hyperplasia, Plasma Cell             |    2                                                                     |     11  2.2|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  51        |
      Ectasia                              |                                                                          |      1  2.0|
      Hyperplasia, Histiocytic             |                                                                          |      1  2.0|
      Pigmentation                         |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  52        |
      Hematopoietic Cell Proliferation     | 2  1  1                                                                  |     42  1.4|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Pigmentation                         | 1  2  2                                                                  |     52  1.5|
      Lymphoid Follicle, Atrophy           |                                                                          |      3  2.3|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +                                                                  |  49        |
      Atrophy                              | 4  4  3                                                                  |     47  3.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  52        |
      Cyst                                 |                                                                          |      1  2.0|
      Hyperplasia                          |       1                                                                  |     23  1.1|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
      Cartilage, Hypertrophy, Focal        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Hydrocephalus                        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 129                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5|                                                                 |            |
                             DAY ON TEST   | 2| 2| 8|                                                                 |            |
                                           | 7| 9| 8|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 6| 6| 6|                                                                 |      A     |
    550                                    | 8| 9| 9|                                                                 |      L     |
    NG/KG                                  | 9| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  51        |
      Infiltration Cellular, Histiocyte    | 1  2  2                                                                  |     49  1.7|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Metaplasia, Squamous                 |                                                                          |      9  1.7|
      Mineralization                       |                                                                          |      1  2.0|
      Thrombosis                           |                                                                          |      1  2.0|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Bronchiolar                     | 1  2  3                                                                  |     47  2.1|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
      Nasolacrimal Duct, Glands,           |                                                                          |            |
          Hyperplasia                      |                                                                          |      1  4.0|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      2  2.5|
      Respiratory Epithelium, Inflammation,|                                                                          |            |
           Suppurative                     |                                                                          |      1  3.0|
      Turbinate, Cyst                      |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  52        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +                                                                  |  52        |
      Cataract                             |                                                                          |      1  3.0|
      Anterior Chamber, Inflammation,      |                                                                          |            |
          Suppurative                      |                                                                          |      1  3.0|
      Cornea, Inflammation, Suppurative    |                                                                          |      1  3.0|
      Retina, Atrophy                      |                                                                          |      1  3.0|
      Retina, Degeneration                 |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +                                                                  |  52        |
      Inflammation                         |                                                                          |      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 130                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5|                                                                 |            |
                             DAY ON TEST   | 2| 2| 8|                                                                 |            |
                                           | 7| 9| 8|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 6| 6| 6|                                                                 |      A     |
    550                                    | 8| 9| 9|                                                                 |      L     |
    NG/KG                                  | 9| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  52        |
      Calculus Micro Observation Only      |                                                                          |      1     |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Mineralization                       | 1  1  1                                                                  |     39  1.1|
      Necrosis                             |                                                                          |      1  3.0|
      Nephropathy                          | 3  2  2                                                                  |     42  2.1|
      Pelvis, Dilatation                   |                                                                          |      1  2.0|
      Transitional Epithelium, Hyperplasia | 4                                                                        |      8  2.3|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  52        |
      Inflammation                         |                                                                          |      4  1.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 131                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 5| 1| 6| 7| 3| 7| 6| 6| 7| 6| 0| 6| 6| 7| 7| 6| 6| 5| 6| 5| 5|             
                             DAY ON TEST   | 2| 8| 6| 6| 3| 8| 0| 0| 0| 2| 5| 2| 2| 0| 7| 6| 3| 0| 2| 2| 0| 6| 1| 8| 8|             
                                           | 7| 1| 3| 3| 0| 8| 7| 4| 9| 7| 0| 1| 7| 7| 2| 0| 0| 0| 7| 1| 7| 2| 1| 8| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1000                                   | 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    NG/KG                                  | 1| 2| 3| 4| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                          2               |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                            X                                             |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Ulcer                                |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      2              2                                    |             
      Basophilic Focus                     | X                                                                        |             
      Basophilic Focus, Multiple           |                                                                          |             
      Cholangiofibrosis                    |                   2  2     2  3     3        3              3  1  2      |             
      Cytoplasmic Alteration               |                                           3                              |             
      Degeneration, Cystic                 | 2                    2                                                   |             
      Eosinophilic Focus                   |                                  X                          X     X      |             
      Eosinophilic Focus, Multiple         |          X              X                                            X   |             
      Fatty Change, Diffuse                | 2  2  2  1  3        2  1  2  1  2  2  2     2  2  2  2  2  1  2  2  2  2|             
      Hepatocyte, Multinucleate            | 2  2  2  2     1  2  2  2  2  2  2  2  1     2  1  2  2  3  2  3  1  1  2|             
      Hepatodiaphragmatic Nodule           |                                                             X            |             
      Hyperplasia, Nodular                 | X  X  X  X        X  X     X  X  X  X  X     X  X  X  X  X  X  X        X|             
      Inflammation                         | 1  1  1  3  1  1  2  2  1  2  1  1  2  1  1  1  1  2  1     1  1  1     1|             
      Mixed Cell Focus                     |                                                             X            |             
      Mixed Cell Focus, Multiple           | X                          X                       X  X                  |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 132                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                           TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126)                       Date: 10/01/03    
Route: GAVAGE                                                                                                     Time: 11:43:51    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 5| 1| 6| 7| 3| 7| 6| 6| 7| 6| 0| 6| 6| 7| 7| 6| 6| 5| 6| 5| 5|             
                             DAY ON TEST   | 2| 8| 6| 6| 3| 8| 0| 0| 0| 2| 5| 2| 2| 0| 7| 6| 3| 0| 2| 2| 0| 6| 1| 8| 8|             
                                           | 7| 1| 3| 3| 0| 8| 7| 4| 9| 7| 0| 1| 7| 7| 2| 0| 0| 0| 7| 1| 7| 2| 1| 8| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1000                                   | 3| 3| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    NG/KG                                  | 1| 2| 3| 4| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Necrosis                             |             3     4                    3              2     2  2         |             
      Pigmentation                         | 3  3  3  3  3     3  2  2  2  3  1  2        2  3  2  2  3  3  3  2  2  2|             
      Toxic Hepatopathy                    | 4  4  4  4  1     4  4  1  4  3  4  4  4     4  4  3  4  4  3  4  2  3  2|             
      Bile Duct, Cyst                      |          2        1        2                          2                  |             
      Bile Duct, Fibrosis                  |          2                       1                                   1   |             
      Bile Duct, Hyperplasia               | 2  2  2  3        3  2     2  2  4  3  3     3  2  2  2  3  3  3  2  3  2|             
      Bile Duct, Inflammation              |                                                                          |             
      Hepatocyte, Degeneration             |                               2                                          |             
      Hepatocyte, Hypertrophy              | 4  4  3  4  3     4  4  1  4  4  3  4  3     3  4  4  3  4  3  4  3  4  4|             
      Oval Cell, Hyperplasia               | 2  3  1  2        2  2     3  2  2  4        1  1  2  3  2     2     2  2|             
      Portal, Fibrosis                     |          2        2  1              3  3                    2            |             
      Serosa, Inflammation                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               | +        +        +  +     +                    +        +  +  +         |             
      Inflammation, Chronic Active         |                            3                                3  2         |             
      Artery, Inflammation, Chronic Active | 3        3           1                                   3  3            |             
      Fat, Necrosis                        |                   2                                                      |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |       +                       +                                          |             
      Gingival, Cyst, Squamous             |                                                                          |             
      Gingival, Hyperplasia, Squamous      |