https://ntp.niehs.nih.gov/go/5256

TDMS Study 96007-03 Pathology Tables

NTP Experiment-Test: 96007-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02
Route: GAVAGE                                                                                                     Time: 11:41:36
                                                          14 WEEK SSAC
       Facility:  Battelle Columbus Laboratory
       Chemical CAS #:  1746-01-6
       Lock Date:  06/28/01
       Cage Range:  All
       Reasons For Removal:    25017 Scheduled Sacrifice
       Removal Date Range:     09/02/98 - 09/03/98
       Treatment Groups:       Include 001    0 NG/KG
                               Include 002    3 NG/KG
                               Include 003    10 NG/KG
                               Include 004    22 NG/KG
                               Include 005    46 NG/KG
                               Include 006    100     NG/KG
a  Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 96007-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02  
Route: GAVAGE                                                                                                     Time: 11:41:36  
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         SPRAGUE-DAWLEY RATS FEMALE                0 NG/KG      3 NG/KG      10 NG/KG     22 NG/KG     46 NG/KG     100             
                                                                                                                    NG/KG           
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DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          98           98           98           98           98           98           
  Scheduled Sacrifice                                 16           16           16           16           16           16           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
  Animals Examined Microscopically                    10           10           10           10           10           10           
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 ALIMENTARY SYSTEM                                                                                                                  
   None                                                                                                                             
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 CARDIOVASCULAR SYSTEM                                                                                                              
   None                                                                                                                             
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 ENDOCRINE SYSTEM                                                                                                                   
   None                                                                                                                             
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 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
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 GENITAL SYSTEM                                                                                                                     
   Uterus                                             (10)         (1)                                                 (10)         
      Deciduoma Benign                                              1 (100%)                                                        
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 HEMATOPOIETIC SYSTEM                                                                                                               
   None                                                                                                                             
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                                                             Page   2                                                               
NTP Experiment-Test: 96007-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02  
Route: GAVAGE                                                                                                     Time: 11:41:36  
____________________________________________________________________________________________________________________________________
         SPRAGUE-DAWLEY RATS FEMALE                0 NG/KG      3 NG/KG      10 NG/KG     22 NG/KG     46 NG/KG     100             
                                                                                                                    NG/KG           
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   Mammary Gland                                      (10)                                                             (10)         
      Carcinoma                                        1 (10%)                                                                      
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 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
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 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
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 RESPIRATORY SYSTEM                                                                                                                 
   None                                                                                                                             
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 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
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 URINARY SYSTEM                                                                                                                     
   None                                                                                                                             
                                                             Page   3                                                               
NTP Experiment-Test: 96007-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 11/25/02  
Route: GAVAGE                                                                                                     Time: 11:41:36  
____________________________________________________________________________________________________________________________________
         SPRAGUE-DAWLEY RATS FEMALE                0 NG/KG      3 NG/KG      10 NG/KG     22 NG/KG     46 NG/KG     100             
                                                                                                                    NG/KG           
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY                                                                                                                       
   Total Animals with Primary Neoplasms (b)             1           1                                                               
     Total Primary Neoplasms                            1           1                                                               
   Total Animals with Benign Neoplasms                              1                                                               
     Total Benign Neoplasms                                         1                                                               
   Total Animals with Malignant Neoplasms               1                                                                           
     Total Malignant Neoplasms                          1                                                                           
   Total Animals with Metastatic Neoplasms                                                                                          
     Total Metastatic Neoplasm                                                                                                      
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
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