https://ntp.niehs.nih.gov/go/5278

TDMS Study 96007-03 Pathology Tables

NTP Experiment-Test: 96007-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/25/02
Route: GAVAGE                                     TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                      Time: 12:05:37
                                                          31 WEEK SSAC
       Facility:  Battelle Columbus Laboratory
       Chemical CAS #:  1746-01-6
       Lock Date:  06/28/01
       Cage Range:  All
       Reasons For Removal:    25017 Scheduled Sacrifice
       Removal Date Range:     12/30/98 - 12/31/98
       Treatment Groups:       Include 001    0 NG/KG
                               Include 002    3 NG/KG
                               Include 003    10 NG/KG
                               Include 004    22 NG/KG
                               Include 005    46 NG/KG
                               Include 006    100     NG/KG
a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
                                                              Page   1
NTP Experiment-Test: 96007-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/25/02    
Route: GAVAGE                                     TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                      Time: 12:05:37    
____________________________________________________________________________________________________________________________________
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG/KG      3 NG/KG      10 NG/KG     22 NG/KG     46 NG/KG     100          
                                                                                                                       NG/KG        
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DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          98           98           98           98           98           98           
  Scheduled Sacrifice                                 16           16           16           16           16           16           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
  Animals Examined Microscopically                    10           10           10           10           10           10           
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 ALIMENTARY SYSTEM                                                                                                                  
   Liver                                              (10)         (10)         (10)         (10)         (10)         (10)         
      Angiectasis                                                   1 [2.0]                                1 [2.0]                  
      Fatty Change, Diffuse                                                                                             6 [1.0]     
      Hepatodiaphragmatic Nodule                                    1                                                               
      Inflammation                                     9 [1.0]      9 [1.3]     10 [1.3]     10 [1.5]     10 [1.5]     10 [1.8]     
      Mitotic Alteration                               1 [2.0]                                                                      
      Mixed Cell Focus                                 1            3            3            2            3            3           
      Mixed Cell Focus, Multiple                       2            4            1                         1            7           
      Necrosis                                                                                                          1 [1.0]     
      Pigmentation                                                  1 [1.0]      8 [1.0]      9 [1.0]     10 [1.0]     10 [2.1]     
      Toxic Hepatopathy                                                                                                10 [2.0]     
      Bile Duct, Hyperplasia                                                                                            1 [2.0]     
      Hepatocyte, Hypertrophy                                       2 [1.0]      3 [1.0]      6 [1.2]      9 [1.3]     10 [2.7]     
      Hepatocyte, Multinucleated                                                                           5 [1.0]      9 [2.0]     
      Oval Cell, Hyperplasia                                                                                            1 [1.0]     
   Pancreas                                           (10)         (10)         (10)         (10)         (10)         (10)         
      Acinus, Atrophy                                  2 [1.0]                   1 [1.0]                   1 [1.0]                  
      Acinus, Vacuolization Cytoplasmic                                                                                 5 [1.0]     
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 CARDIOVASCULAR SYSTEM                                                                                                              
   None                                                                                                                             
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 ENDOCRINE SYSTEM                                                                                                                   
   Adrenal Cortex                                     (10)         (10)         (10)         (10)         (10)         (10)         
      Degeneration, Cystic                                                                    1 [2.0]      1 [2.0]                  
      Hyperplasia                                                                             1 [2.0]                               
      Hypertrophy                                                   2 [1.5]      3 [1.3]      3 [1.3]      3 [1.3]      3 [1.0]     
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                             Page    2                                                              
NTP Experiment-Test: 96007-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/25/02    
Route: GAVAGE                                     TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                      Time: 12:05:37    
____________________________________________________________________________________________________________________________________
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG/KG      3 NG/KG      10 NG/KG     22 NG/KG     46 NG/KG     100          
                                                                                                                       NG/KG        
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT                                                                                                             
      Necrosis                                                                                1 [1.0]                               
   Thyroid Gland                                      (10)         (10)         (10)         (10)         (10)         (10)         
      Follicular Cell, Hypertrophy                                  3 [1.7]      3 [1.7]      3 [1.3]      4 [1.3]      6 [1.8]     
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 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
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 GENITAL SYSTEM                                                                                                                     
   Ovary                                              (10)                                                             (10)         
      Atrophy                                          9 [3.9]                                                          7 [4.0]     
   Uterus                                             (10)         (1)                                                 (10)         
      Inflammation, Suppurative                                     1 [2.0]                                                         
      Metaplasia, Squamous                             8 [1.5]                                                          4 [1.0]     
      Endometrium, Hyperplasia, Cystic                 1 [3.0]      1 [4.0]                                             2 [4.0]     
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 HEMATOPOIETIC SYSTEM                                                                                                               
   Spleen                                             (10)                                                             (10)         
      Pigmentation                                    10 [1.2]                                                         10 [1.2]     
   Thymus                                             (10)         (10)         (10)         (10)         (10)         (10)         
      Atrophy                                          2 [2.0]      1 [1.0]      5 [1.6]      6 [1.8]      7 [2.0]     10 [3.1]     
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 INTEGUMENTARY SYSTEM                                                                                                               
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
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 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                             Page    3                                                              
NTP Experiment-Test: 96007-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 11/25/02    
Route: GAVAGE                                     TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                      Time: 12:05:37    
____________________________________________________________________________________________________________________________________
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG/KG      3 NG/KG      10 NG/KG     22 NG/KG     46 NG/KG     100          
                                                                                                                       NG/KG        
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                               (10)         (10)         (10)         (10)         (10)         (10)         
      Infiltration Cellular, Histiocyte                2 [1.0]      3 [1.0]      1 [1.0]      1 [1.0]                   1 [1.0]     
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 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
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 URINARY SYSTEM                                                                                                                     
   None                                                                                                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
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