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TDMS Study 96007-03 Pathology Tables

NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03
Route: GAVAGE                                                                                                     Time: 08:37:20

                                                         FINAL # 3 RATS




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  1746-01-6

       Lock Date:  06/28/01

       Cage Range:  All

       Reasons For Removal:    25018 Dosing Accident                   25019 Moribund Sacrifice
                               25020 Natural Death                     25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All



































                                                              Page   1


NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 5| 4| 6| 7| 7| 7| 5| 7| 3| 6| 6| 3| 1| 7| 7| 4| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 6| 3| 3| 8| 7| 3| 3| 3| 2| 3| 5| 9| 4| 6| 8| 3| 2| 9| 3| 3| 3| 4|             
                                           | 3| 1| 1| 6| 3| 3| 7| 5| 2| 2| 3| 6| 1| 1| 4| 5| 1| 5| 2| 2| 2| 1| 1| 1| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 4| 5| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Inflammation             |                                                             2            |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                              X        X                  |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                                           X                 X  X         |             
      Basophilic Focus, Multiple           | X                                                                       X|             
      Cholangiofibrosis                    |                                              1                           |             
      Clear Cell Focus                     |    X                                                                     |             
      Clear Cell Focus, Multiple           |                                                                      X   |             
      Congestion                           |                                                                         1|             
      Eosinophilic Focus                   |    X        X                                X        X                  |             
      Eosinophilic Focus, Multiple         | X                       X                                                |             
      Fatty Change, Focal                  |                                           2                          1   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation                         | 1  1           2  1  1  1     1  1  1  1     1  1        1     1     1   |             
      Mixed Cell Focus                     |       X                 X                             X                  |             
      Mixed Cell Focus, Multiple           |    X        X              X  X           X  X           X  X  X  X  X   |             
      Necrosis                             |                                                                          |             
      Pigmentation                         |                1                                                         |             
      Bile Duct, Cyst                      |                                                                         4|             
      Bile Duct, Hyperplasia               | 2              1                    2                                2   |             
      Centrilobular, Degeneration          |                                                                         2|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 5| 4| 6| 7| 7| 7| 5| 7| 3| 6| 6| 3| 1| 7| 7| 4| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 6| 3| 3| 8| 7| 3| 3| 3| 2| 3| 5| 9| 4| 6| 8| 3| 2| 9| 3| 3| 3| 4|             
                                           | 3| 1| 1| 6| 3| 3| 7| 5| 2| 2| 3| 6| 1| 1| 4| 5| 1| 5| 2| 2| 2| 1| 1| 1| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 4| 5| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                                                         +|             
      Metaplasia, Osseous                  |                                                                         2|             
      Vein, Thrombosis                     |                                                                         3|             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
      Gingival, Hyperplasia, Squamous      |                                                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                                                          |             
      Acinus, Hyperplasia                  |                                                       2                  |             
      Acinus, Vacuolization Cytoplasmic    |                                                                         2|             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                               3                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                1                                                         |             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation                         |                                                                          |             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Mineralization                       |          1                                   1                           |             
                                           |__________________________________________________________________________|             
   Tooth                                   |          +           +  +  +        +        +     +           +  +     +|             
      Peridontal Tissue, Fibrosis          |                                                                          |             
      Peridontal Tissue, Inflammation      |          1           2  1  2        1        2     1           3  1     1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                       1        1         |             
      Mineralization                       |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 5| 4| 6| 7| 7| 7| 5| 7| 3| 6| 6| 3| 1| 7| 7| 4| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 6| 3| 3| 8| 7| 3| 3| 3| 2| 3| 5| 9| 4| 6| 8| 3| 2| 9| 3| 3| 3| 4|             
                                           | 3| 1| 1| 6| 3| 3| 7| 5| 2| 2| 3| 6| 1| 1| 4| 5| 1| 5| 2| 2| 2| 1| 1| 1| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 4| 5| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       1                 2  1  2              1                          1|             
      Atrophy                              |                                                                          |             
      Degeneration, Cystic                 |             3                       3                 3                 3|             
      Hyperplasia                          |          2        1  1     2  2                       2              2   |             
      Hypertrophy                          | 2  2  3  2  3        2  1  2  2  1  3     3  4        3  1     3  2  2  2|             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Vacuolization Cytoplasmic            |                            1  2                                1  1  1   |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    1        2     2                 1     2           1  1     2  2  1   |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2                       2  2  3     3     1  2        3  3        3      |             
      Atypia Cellular                      |                                                                2         |             
      Cyst                                 |                                                                          |             
      Cytoplasmic Alteration               |                                                                          |             
      Developmental Malformation           |                                                                          |             
      Pars Distalis, Hyperplasia           |       1  3  2  2  2  1  2        2        2                 2  3     3   |             
      Pars Intermedia, Hyperplasia         |                                  2                                   3   |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                         3                                                |             
      C-Cell, Hyperplasia                  | 1     1  2  1        3                                1           3  3   |             
      Follicular Cell, Hyperplasia         |                         2                                                |             
      Follicular Cell, Hypertrophy         |    3                                            2              2         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 5| 4| 6| 7| 7| 7| 5| 7| 3| 6| 6| 3| 1| 7| 7| 4| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 6| 3| 3| 8| 7| 3| 3| 3| 2| 3| 5| 9| 4| 6| 8| 3| 2| 9| 3| 3| 3| 4|             
                                           | 3| 1| 1| 6| 3| 3| 7| 5| 2| 2| 3| 6| 1| 1| 4| 5| 1| 5| 2| 2| 2| 1| 1| 1| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 4| 5| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Basal Cell              |                         2                                                |             
      Inflammation                         | 1  1  2     1     1  1  1  2  2  3        2  1     2  1  2  2  2  1  1  1|             
      Duct, Cyst                           | 2  2        3     2  2  3  2  4  2           2        2  1  1  4  3  2  2|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4  4  4  4  4  4  4  4  4  4  4  4     4  4  4  4  4  4        4  4  4|             
      Cyst                                 |    2     3  2  3        3  3  2     3                          3  3      |             
                                           |__________________________________________________________________________|             
   Oviduct                                 |                                     +                                    |             
      Inflammation                         |                                     3                                    |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                   2                                                      |             
      Inflammation, Suppurative            |                            2                       1           2         |             
      Metaplasia, Squamous                 | 2  2              3  1  2  3     1  4  2  1     2        1     3     2  1|             
      Endometrium, Hyperplasia, Cystic     |       3  1           2  1     3  2           2  2        2        1     2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       3  2  3  4  3  4  3  3     3     3  2  3  3  3     3  3  4        3|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
      Lumbar, Ectasia                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Plasma Cell             | 2  2  2        2                    2        2                    2      |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Histiocytic             |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 1  1  1  1  2  1     3  3  2  1  1  1     2  2     1  1  2  1  3  2  1  2|             
      Hyperplasia, Lymphoid                |                                              2                           |             
      Pigmentation                         | 2  2  1  1     1        1  1  1  1  3     2  1  2  1  2  2  1  1  2  2  1|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 5| 4| 6| 7| 7| 7| 5| 7| 3| 6| 6| 3| 1| 7| 7| 4| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 6| 3| 3| 8| 7| 3| 3| 3| 2| 3| 5| 9| 4| 6| 8| 3| 2| 9| 3| 3| 3| 4|             
                                           | 3| 1| 1| 6| 3| 3| 7| 5| 2| 2| 3| 6| 1| 1| 4| 5| 1| 5| 2| 2| 2| 1| 1| 1| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 4| 5| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Lymphoid Follicle, Atrophy           |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2  2        3  3  2  3  4     2  3        3  2        2  2  2  3  3  1  3|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          | 1              1  1     1  1     1        1  1        3     2  1  1  1   |             
      Inflammation, Granulomatous          |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebellum, Developmental            |                                                                          |             
          Malformation                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 2        2  2  1  2  2  1     2  1     1  2  3        1  2  1  2  2      |             
      Inflammation, Granulomatous          |                                              1           1               |             
      Inflammation, Suppurative            |                   3                                                      |             
      Metaplasia, Squamous                 |                                                                          |             
      Mineralization                       |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                      1                    1  1                    1      |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 5| 4| 6| 7| 7| 7| 5| 7| 3| 6| 6| 3| 1| 7| 7| 4| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 6| 3| 3| 8| 7| 3| 3| 3| 2| 3| 5| 9| 4| 6| 8| 3| 2| 9| 3| 3| 3| 4|             
                                           | 3| 1| 1| 6| 3| 3| 7| 5| 2| 2| 3| 6| 1| 1| 4| 5| 1| 5| 2| 2| 2| 1| 1| 1| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 4| 5| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                           2                              |             
      Nasolacrimal Duct, Inflammation      |                         2                                                |             
      Squamous Epithelium, Inflammation,   |                                                                          |             
           Suppurative                     |                                                 1                        |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Retina, Atrophy                      |    2                       2                                         2   |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                               2                                          |             
      Inflammation                         |                               2              1                           |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                          2               |             
      Casts Protein                        |          2                                                               |             
      Cyst                                 |                         2                                                |             
      Inflammation, Chronic Active         | 1                       2  1  1                 1                        |             
      Mineralization                       | 1  1  1  1           1  1  1  1  1  1     1     1  1  1  1     1     1   |             
      Nephropathy                          |    1           3  1     2  1     1  1     1  1     1  1  1     1  1  1   |             
      Pelvis, Dilatation                   |                3        3                                                |             
      Pelvis, Inflammation                 |                         3                                            3   |             
      Transitional Epithelium, Hyperplasia |                         3                                            2   |             
                                           |__________________________________________________________________________|             
   Ureter                                  |                         +                                                |             
      Inflammation                         |                         2                                                |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 5| 4| 6| 7| 7| 7| 5| 7| 3| 6| 6| 3| 1| 7| 7| 4| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 6| 3| 3| 8| 7| 3| 3| 3| 2| 3| 5| 9| 4| 6| 8| 3| 2| 9| 3| 3| 3| 4|             
                                           | 3| 1| 1| 6| 3| 3| 7| 5| 2| 2| 3| 6| 1| 1| 4| 5| 1| 5| 2| 2| 2| 1| 1| 1| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 1| 2| 3| 4| 5| 1| 4| 5| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
      Transitional Epithelium, Hyperplasia |                         3                                                |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                         2                                            3   |             
      Transitional Epithelium, Hyperplasia |                                                                      2   |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 6| 6| 3| 5| 4| 1| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 4| 6| 9| 3| 3| 3| 3| 3| 3| 1| 1| 0| 1| 4| 6| 6| 4| 7| 6| 4| 3| 3| 3| 3|             
                                           | 2| 7| 9| 7| 2| 3| 3| 3| 1| 1| 2| 7| 1| 0| 6| 8| 6| 8| 4| 9| 6| 2| 2| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG/KG                                | 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|             
                                           | 0| 1| 2| 3| 4| 7| 8| 9| 1| 2| 3| 4| 1| 3| 5| 1| 2| 3| 4| 6| 7| 8| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Inflammation             |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                     X                                    |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |    X     X                       X                                      X|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      1                                                   |             
      Basophilic Focus                     |    X           X              X  X        X                              |             
      Basophilic Focus, Multiple           |             X                                               X            |             
      Cholangiofibrosis                    |                                                                          |             
      Clear Cell Focus                     | X                                X                 X                     |             
      Clear Cell Focus, Multiple           |                                                                          |             
      Congestion                           |                   1                                                      |             
      Eosinophilic Focus                   |          X           X           X        X                              |             
      Eosinophilic Focus, Multiple         |    X                                                                     |             
      Fatty Change, Focal                  |                                                                          |             
      Hematopoietic Cell Proliferation     |                                           2                              |             
      Inflammation                         |    1           1  1  1     1  1     2     1  1  1  1        1  2  1  1  1|             
      Mixed Cell Focus                     |                                  X                                       |             
      Mixed Cell Focus, Multiple           | X        X  X  X  X  X     X              X        X           X  X  X  X|             
      Necrosis                             |                                     2                                    |             
      Pigmentation                         |          1                          1                          1         |             
      Bile Duct, Cyst                      |             3  3                                                         |             
      Bile Duct, Hyperplasia               |                                                                   1      |             
      Centrilobular, Degeneration          |                                     3                                    |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 6| 6| 3| 5| 4| 1| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 4| 6| 9| 3| 3| 3| 3| 3| 3| 1| 1| 0| 1| 4| 6| 6| 4| 7| 6| 4| 3| 3| 3| 3|             
                                           | 2| 7| 9| 7| 2| 3| 3| 3| 1| 1| 2| 7| 1| 0| 6| 8| 6| 8| 4| 9| 6| 2| 2| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG/KG                                | 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|             
                                           | 0| 1| 2| 3| 4| 7| 8| 9| 1| 2| 3| 4| 1| 3| 5| 1| 2| 3| 4| 6| 7| 8| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                                          +               |             
      Metaplasia, Osseous                  |                                                                          |             
      Vein, Thrombosis                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |                                                 +                       +|             
      Gingival, Hyperplasia, Squamous      |                                                                         4|             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                   1                                                      |             
      Acinus, Hyperplasia                  |                                                             3            |             
      Acinus, Vacuolization Cytoplasmic    |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Squamous                |             1     1                 2                                    |             
      Inflammation                         |                                                 3                        |             
      Ulcer                                |                                     2           3                        |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                     3                                    |             
      Mineralization                       |                                                          2               |             
                                           |__________________________________________________________________________|             
   Tooth                                   | +                       +           +                             +  +  +|             
      Peridontal Tissue, Fibrosis          |                         2                                                |             
      Peridontal Tissue, Inflammation      | 2                                   3                             2  2  2|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |                                                          3               |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    1        1     1  1        1           1              2     2         |             
      Mineralization                       |                                                          2               |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 6| 6| 3| 5| 4| 1| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 4| 6| 9| 3| 3| 3| 3| 3| 3| 1| 1| 0| 1| 4| 6| 6| 4| 7| 6| 4| 3| 3| 3| 3|             
                                           | 2| 7| 9| 7| 2| 3| 3| 3| 1| 1| 2| 7| 1| 0| 6| 8| 6| 8| 4| 9| 6| 2| 2| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG/KG                                | 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|             
                                           | 0| 1| 2| 3| 4| 7| 8| 9| 1| 2| 3| 4| 1| 3| 5| 1| 2| 3| 4| 6| 7| 8| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          2        1                       2  1                           |             
      Atrophy                              |                                                             2            |             
      Degeneration, Cystic                 |    2                             2  2     3  1              2            |             
      Hyperplasia                          |    2     2        3                                         1  3     3  2|             
      Hypertrophy                          | 2  2     2  2  2  2  1     1     2  2     3  3     1  2     2  1  3  3  2|             
      Inflammation, Chronic Active         |                                                                2         |             
      Inflammation, Suppurative            |          1                                                               |             
      Vacuolization Cytoplasmic            |                   2                       1     1                        |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3        2     1                 2  2     2  3                    2     2|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  M  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                          2               |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    3     3  1  2        2     3  3  1     2           2           2     3|             
      Atypia Cellular                      |                                                                          |             
      Cyst                                 |                                                          2               |             
      Cytoplasmic Alteration               |                1                                                         |             
      Developmental Malformation           |                                                          X               |             
      Pars Distalis, Hyperplasia           | 3           2     2  2                             1           3     2   |             
      Pars Intermedia, Hyperplasia         |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      C-Cell, Hyperplasia                  |                3  2  2           2  1     1  2              1  2  2      |             
      Follicular Cell, Hyperplasia         |             3                                                            |             
      Follicular Cell, Hypertrophy         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 6| 6| 3| 5| 4| 1| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 4| 6| 9| 3| 3| 3| 3| 3| 3| 1| 1| 0| 1| 4| 6| 6| 4| 7| 6| 4| 3| 3| 3| 3|             
                                           | 2| 7| 9| 7| 2| 3| 3| 3| 1| 1| 2| 7| 1| 0| 6| 8| 6| 8| 4| 9| 6| 2| 2| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG/KG                                | 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|             
                                           | 0| 1| 2| 3| 4| 7| 8| 9| 1| 2| 3| 4| 1| 3| 5| 1| 2| 3| 4| 6| 7| 8| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  M  +  +  +  +  +  +  +|             
      Hyperplasia, Basal Cell              |                                                                          |             
      Inflammation                         | 1  2  1  2  2  3  2  2           3        1  1  1     2  1  2  3     2  1|             
      Duct, Cyst                           | 2  3        1  3  2  1        1  3        2  1        3  3  3  3        3|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4  4  4  4  4  4  4  4  4  4  4  4     4  4  4  4  4  4  4  4  4  4  4|             
      Cyst                                 |          2  2                                      2                 2   |             
                                           |__________________________________________________________________________|             
   Oviduct                                 |                                  +                                       |             
      Inflammation                         |                                  3                                       |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |    2           1                    1                          4         |             
      Metaplasia, Squamous                 | 1  3  1  3  1  1  2        2     1                 3  2        4  2      |             
      Endometrium, Hyperplasia, Cystic     | 2     1     3  3  3  2  1  2     3  2     2  2     2  2           2  2   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    4  3  3  2                 3  2  3  4  3  3  4  3  3  2  2  3        3|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |             +                    +                                       |             
      Lumbar, Ectasia                      |                                  3                                       |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                 2                        |             
      Hyperplasia, Plasma Cell             | 2        2  2  2     2     2     2        2  3  2     2     2     2  2  2|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Histiocytic             |       2                                                                  |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2  1     3  1  1  1  1  1  1     1  3     3  2  1  1  2     1  1  1  1  1|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation                         | 1  1  2  1  1  2  2  2     2  2  1     1  1  2  1     1  2  2  2  2  1   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 6| 6| 3| 5| 4| 1| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 4| 6| 9| 3| 3| 3| 3| 3| 3| 1| 1| 0| 1| 4| 6| 6| 4| 7| 6| 4| 3| 3| 3| 3|             
                                           | 2| 7| 9| 7| 2| 3| 3| 3| 1| 1| 2| 7| 1| 0| 6| 8| 6| 8| 4| 9| 6| 2| 2| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG/KG                                | 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|             
                                           | 0| 1| 2| 3| 4| 7| 8| 9| 1| 2| 3| 4| 1| 3| 5| 1| 2| 3| 4| 6| 7| 8| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Lymphoid Follicle, Atrophy           |       3                 2                       2        2               |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2  2  4  2     3  2  2     2     2              4     2  3     3  3  3  3|             
      Hemorrhage                           |       3                                                                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    3                    2                 3     2                        |             
      Hyperplasia                          | 2  1        2        1        1     2     1  1              1        2  1|             
      Inflammation, Granulomatous          |                                                 2                        |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebellum, Developmental            |                                                                          |             
          Malformation                     | 3                                                                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 2  2  2  3  3  2     1  2  2  3  2  1     1  1     2  1     2  2  2  3  2|             
      Inflammation, Granulomatous          |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Metaplasia, Squamous                 |                                                                      1   |             
      Mineralization                       |                                                          2               |             
      Alveolar Epithelium, Hyperplasia     | 1  1     2  1                    1                                   1   |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     |                                                                   1      |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  13                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 6| 6| 3| 5| 4| 1| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 4| 6| 9| 3| 3| 3| 3| 3| 3| 1| 1| 0| 1| 4| 6| 6| 4| 7| 6| 4| 3| 3| 3| 3|             
                                           | 2| 7| 9| 7| 2| 3| 3| 3| 1| 1| 2| 7| 1| 0| 6| 8| 6| 8| 4| 9| 6| 2| 2| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG/KG                                | 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|             
                                           | 0| 1| 2| 3| 4| 7| 8| 9| 1| 2| 3| 4| 1| 3| 5| 1| 2| 3| 4| 6| 7| 8| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                       3                  |             
      Nasolacrimal Duct, Inflammation      |                                                 2                        |             
      Squamous Epithelium, Inflammation,   |                                                                          |             
           Suppurative                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |                                  +  +                                    |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                 4                        |             
      Hemorrhage                           |                                                 2                        |             
      Retina, Atrophy                      |                                                                3         |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                                                          |             
      Inflammation                         | 1                    1     2     1           1  2     1     1     1      |             
                                           |__________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                                          |             
      Casts Protein                        |          1                    1                                          |             
      Cyst                                 |                         3                                                |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       | 1  1  1  1  1  1  1        1     1  1     1  1     1  1  3  1  1  1  1  1|             
      Nephropathy                          | 2  1     1  1  1  2  1     1  1              1           3  1  1  1  1  1|             
      Pelvis, Dilatation                   |                                                                          |             
      Pelvis, Inflammation                 |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                          2               |             
                                           |__________________________________________________________________________|             
   Ureter                                  |                                                                          |             
      Inflammation                         |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  14                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 4| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 6| 6| 3| 5| 4| 1| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 4| 6| 9| 3| 3| 3| 3| 3| 3| 1| 1| 0| 1| 4| 6| 6| 4| 7| 6| 4| 3| 3| 3| 3|             
                                           | 2| 7| 9| 7| 2| 3| 3| 3| 1| 1| 2| 7| 1| 0| 6| 8| 6| 8| 4| 9| 6| 2| 2| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 NG/KG                                | 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9|             
                                           | 0| 1| 2| 3| 4| 7| 8| 9| 1| 2| 3| 4| 1| 3| 5| 1| 2| 3| 4| 6| 7| 8| 1| 2| 3|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |          1                       1                             1         |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  15                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 3| 3| 3|                                                                 |            |
                                           | 3| 3| 1|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 0| 0| 0|                                                                 |      A     |
    0 NG/KG                                | 9| 9| 9|                                                                 |      L     |
                                           | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  52        |
      Muscularis, Inflammation             |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  52        |
      Parasite Metazoan                    |                                                                          |      1     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  52        |
      Parasite Metazoan                    |                                                                          |      6     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  51        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  51        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  51        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Angiectasis                          | 2                                                                        |      2  1.5|
      Basophilic Focus                     |                                                                          |      8     |
      Basophilic Focus, Multiple           |                                                                          |      4     |
      Cholangiofibrosis                    |                                                                          |      1  1.0|
      Clear Cell Focus                     |                                                                          |      4     |
      Clear Cell Focus, Multiple           |                                                                          |      1     |
      Congestion                           |                                                                          |      2  1.0|
      Eosinophilic Focus                   |                                                                          |      8     |
      Eosinophilic Focus, Multiple         |                                                                          |      3     |
      Fatty Change, Focal                  |                                                                          |      2  1.5|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Inflammation                         |    1  1                                                                  |     33  1.1|
      Mixed Cell Focus                     |                                                                          |      4     |
      Mixed Cell Focus, Multiple           | X     X                                                                  |     26     |
      Necrosis                             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  16                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 3| 3| 3|                                                                 |            |
                                           | 3| 3| 1|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 0| 0| 0|                                                                 |      A     |
    0 NG/KG                                | 9| 9| 9|                                                                 |      L     |
                                           | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Pigmentation                         |                                                                          |      4  1.0|
      Bile Duct, Cyst                      |                                                                          |      3  3.3|
      Bile Duct, Hyperplasia               |                                                                          |      5  1.6|
      Centrilobular, Degeneration          |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Metaplasia, Osseous                  |                                                                          |      1  2.0|
      Vein, Thrombosis                     |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   2        |
      Gingival, Hyperplasia, Squamous      |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  51        |
      Acinus, Atrophy                      |                                                                          |      1  1.0|
      Acinus, Hyperplasia                  |                                                                          |      2  2.5|
      Acinus, Vacuolization Cytoplasmic    |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  51        |
      Mineralization                       |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  53        |
      Hyperkeratosis                       |                                                                          |      1  1.0|
      Hyperplasia, Squamous                |                                                                          |      3  1.3|
      Inflammation                         |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  53        |
      Erosion                              |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      3  1.3|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                                                                          |  16        |
      Peridontal Tissue, Fibrosis          |                                                                          |      1  2.0|
      Peridontal Tissue, Inflammation      |                                                                          |     15  1.7|
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  17                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 3| 3| 3|                                                                 |            |
                                           | 3| 3| 1|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 0| 0| 0|                                                                 |      A     |
    0 NG/KG                                | 9| 9| 9|                                                                 |      L     |
                                           | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +                                                                  |  53        |
      Aorta, Mineralization                |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  53        |
      Cardiomyopathy                       |                                                                          |     10  1.2|
      Mineralization                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
      Angiectasis                          | 2                                                                        |     11  1.5|
      Atrophy                              |       3                                                                  |      2  2.5|
      Degeneration, Cystic                 |       3                                                                  |     11  2.5|
      Hyperplasia                          | 2     2                                                                  |     16  2.0|
      Hypertrophy                          | 2  1  4                                                                  |     41  2.1|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Vacuolization Cytoplasmic            | 3  1  1                                                                  |     11  1.4|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  53        |
      Hyperplasia                          |                                                                          |     19  1.8|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  51        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +                                                                  |  46        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  53        |
      Angiectasis                          | 1  3  3                                                                  |     25  2.3|
      Atypia Cellular                      |                                                                          |      1  2.0|
      Cyst                                 |                                                                          |      1  2.0|
      Cytoplasmic Alteration               |                                                                          |      1  1.0|
      Developmental Malformation           |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  18                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 3| 3| 3|                                                                 |            |
                                           | 3| 3| 1|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 0| 0| 0|                                                                 |      A     |
    0 NG/KG                                | 9| 9| 9|                                                                 |      L     |
                                           | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Pars Distalis, Hyperplasia           |                                                                          |     19  2.1|
      Pars Intermedia, Hyperplasia         |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  52        |
      Cyst                                 |                                                                          |      1  3.0|
      C-Cell, Hyperplasia                  | 2                                                                        |     19  1.8|
      Follicular Cell, Hyperplasia         |                                                                          |      2  2.5|
      Follicular Cell, Hypertrophy         |                                                                          |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +                                                                  |  50        |
      Hyperplasia, Basal Cell              |                                                                          |      1  2.0|
      Inflammation                         | 1  1  1                                                                  |     41  1.6|
      Duct, Cyst                           | 1     2                                                                  |     34  2.2|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  51        |
      Atrophy                              | 4  4  4                                                                  |     49  4.0|
      Cyst                                 |                                                                          |     14  2.5|
                                           |__________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |   2        |
      Inflammation                         |                                                                          |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +                                                                  |  52        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      7  1.9|
      Metaplasia, Squamous                 |    3                                                                     |     29  2.0|
      Endometrium, Hyperplasia, Cystic     | 2  1  3                                                                  |     30  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  19                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 3| 3| 3|                                                                 |            |
                                           | 3| 3| 1|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 0| 0| 0|                                                                 |      A     |
    0 NG/KG                                | 9| 9| 9|                                                                 |      L     |
                                           | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
   Bone Marrow                             | +  +  +                                                                  |  53        |
      Hyperplasia                          |    2                                                                     |     36  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   2        |
      Lumbar, Ectasia                      |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  51        |
      Congestion                           |                                                                          |      1  2.0|
      Hyperplasia, Plasma Cell             | 2  3  3                                                                  |     25  2.1|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  52        |
      Hyperplasia, Histiocytic             |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  51        |
      Hematopoietic Cell Proliferation     | 1  1  1                                                                  |     46  1.5|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Pigmentation                         | 1  2  1                                                                  |     45  1.5|
      Lymphoid Follicle, Atrophy           |                                                                          |      4  2.3|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +                                                                  |  51        |
      Atrophy                              | 3  2                                                                     |     36  2.6|
      Hemorrhage                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  53        |
      Cyst                                 |                                                                          |      4  2.5|
      Hyperplasia                          |    3                                                                     |     25  1.4|
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +                                                                  |  53        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  20                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 3| 3| 3|                                                                 |            |
                                           | 3| 3| 1|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 0| 0| 0|                                                                 |      A     |
    0 NG/KG                                | 9| 9| 9|                                                                 |      L     |
                                           | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
      Cerebellum, Developmental            |                                                                          |            |
          Malformation                     |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  53        |
      Infiltration Cellular, Histiocyte    | 2  2  2                                                                  |     41  1.9|
      Inflammation, Granulomatous          |                                                                          |      2  1.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Metaplasia, Squamous                 |                                                                          |      1  1.0|
      Mineralization                       |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     | 1     1                                                                  |     12  1.1|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Bronchiolar                     |    1                                                                     |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |      2  2.5|
      Nasolacrimal Duct, Inflammation      |                                                                          |      2  2.0|
      Squamous Epithelium, Inflammation,   |                                                                          |            |
           Suppurative                     |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  52        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ear                                     |                                                                          |   2        |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  21                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7|                                                                 |            |
                             DAY ON TEST   | 3| 3| 3|                                                                 |            |
                                           | 3| 3| 1|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 0| 0| 0|                                                                 |      A     |
    0 NG/KG                                | 9| 9| 9|                                                                 |      L     |
                                           | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
      Degeneration                         |                                                                          |      1  4.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Retina, Atrophy                      | 1                                                                        |      5  2.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +                                                                  |  53        |
      Atrophy, Focal                       |                                                                          |      1  2.0|
      Inflammation                         |       1                                                                  |     12  1.3|
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  53        |
      Calculus Micro Observation Only      |                                                                          |      1  2.0|
      Casts Protein                        |                                                                          |      3  1.3|
      Cyst                                 |                                                                          |      2  2.5|
      Inflammation, Chronic Active         |                                                                          |      5  1.2|
      Mineralization                       | 1  1  1                                                                  |     40  1.1|
      Nephropathy                          | 1  1  1                                                                  |     34  1.2|
      Pelvis, Dilatation                   |                                                                          |      2  3.0|
      Pelvis, Inflammation                 |                                                                          |      2  3.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      3  2.3|
                                           |__________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
      Inflammation                         |                                                                          |      1  2.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  52        |
      Inflammation                         |    1                                                                     |      6  1.5|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  22                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 5| 4| 7| 5| 6| 6| 7| 4| 5| 2| 4| 5| 3| 6| 3| 7| 7| 7| 7| 7| 7| 2|             
                             DAY ON TEST   | 5| 4| 3| 5| 4| 3| 2| 4| 4| 3| 9| 5| 4| 4| 7| 9| 8| 4| 3| 3| 3| 3| 3| 2| 6|             
                                           | 6| 8| 1| 6| 9| 3| 6| 8| 7| 2| 0| 6| 1| 8| 8| 4| 1| 1| 1| 3| 3| 1| 2| 9| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    3 NG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Inflammation             |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                             X            |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          1                                                               |             
      Basophilic Focus                     |       X                                   X                       X      |             
      Basophilic Focus, Multiple           |                                                                          |             
      Cholangiofibrosis                    |    1                                                                     |             
      Clear Cell Focus                     |                                                          X               |             
      Eosinophilic Focus                   |          X  X                                         X  X               |             
      Eosinophilic Focus, Multiple         | X                 X        X                                      X      |             
      Fatty Change, Diffuse                |                                                    1                     |             
      Fatty Change, Focal                  |          2        2                                                      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                   X                                                      |             
      Inflammation                         | 1  1  2  1  1  1  1  1  1        1  1  1  2  1  1  2  1  1  1  1        1|             
      Mixed Cell Focus                     | X        X                                   X              X  X         |             
      Mixed Cell Focus, Multiple           |                X  X  X                          X                        |             
      Necrosis                             |                                                    2           1         |             
      Pigmentation                         |                         1                 1           1  1               |             
      Toxic Hepatopathy                    |                                           1              1               |             
      Bile Duct, Cyst                      |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  23                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 5| 4| 7| 5| 6| 6| 7| 4| 5| 2| 4| 5| 3| 6| 3| 7| 7| 7| 7| 7| 7| 2|             
                             DAY ON TEST   | 5| 4| 3| 5| 4| 3| 2| 4| 4| 3| 9| 5| 4| 4| 7| 9| 8| 4| 3| 3| 3| 3| 3| 2| 6|             
                                           | 6| 8| 1| 6| 9| 3| 6| 8| 7| 2| 0| 6| 1| 8| 8| 4| 1| 1| 1| 3| 3| 1| 2| 9| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    3 NG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Bile Duct, Fibrosis                  |                                                                          |             
      Bile Duct, Hyperplasia               |                                           1           1              1   |             
      Centrilobular, Degeneration          |                                        2                                 |             
      Hepatocyte, Hypertrophy              | 2     1        1  1  1           1        1           1  1     2         |             
      Oval Cell, Hyperplasia               |                                           1           1  1               |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |       +     +  +        +              +                 +               |             
      Gingival, Hyperplasia, Squamous      |       1     1  1                       2                 2               |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                                 1                        |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Squamous                |       1                                                              2   |             
      Inflammation                         |                                                                      2   |             
      Ulcer                                |                                                                      2   |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tooth                                   | +           +  +                                      +  +  +     +      |             
      Peridontal Tissue, Inflammation      | 1           1  1                                      1  1  1     1      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                       1  1     1     1   |             
      Artery, Mineralization               |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  24                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 5| 4| 7| 5| 6| 6| 7| 4| 5| 2| 4| 5| 3| 6| 3| 7| 7| 7| 7| 7| 7| 2|             
                             DAY ON TEST   | 5| 4| 3| 5| 4| 3| 2| 4| 4| 3| 9| 5| 4| 4| 7| 9| 8| 4| 3| 3| 3| 3| 3| 2| 6|             
                                           | 6| 8| 1| 6| 9| 3| 6| 8| 7| 2| 0| 6| 1| 8| 8| 4| 1| 1| 1| 3| 3| 1| 2| 9| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    3 NG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 1              2                                2        2  2     2      |             
      Degeneration, Cystic                 |       2        1     2        2  2                          1  2  3      |             
      Hyperplasia                          |    3  1  2                          1                    2  3            |             
      Hypertrophy                          | 3  3  3  1     3  1  2  1  2  3  3     2  2  1  2     1  2  3  3  3  2   |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |    1  1                                                                  |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                          2               |             
      Hyperplasia                          |                3  2     3  2                    1     2                  |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      1  3                             3  3  3  2         |             
      Cyst                                 |                   3                                                      |             
      Vacuolization Cytoplasmic            |                         2  1                                             |             
      Pars Distalis, Hyperplasia           | 2        2           2        1           1                       2  3   |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                             2            |             
      C-Cell, Hyperplasia                  |    3  2  3  3        3              2     1     2     3     2            |             
      Follicular Cell, Hyperplasia         |                                                    3                     |             
      Follicular Cell, Hypertrophy         |       1              1                                         3         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 2  2  1  2  1  1  1  2  2  1  1  2     2     1  3  2  2  2  1  1  2      |             
      Duct, Cyst                           | 1  2     2  2     3  1  2  3           1  2  1  2  2  3     1  3  2  2   |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  25                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 5| 4| 7| 5| 6| 6| 7| 4| 5| 2| 4| 5| 3| 6| 3| 7| 7| 7| 7| 7| 7| 2|             
                             DAY ON TEST   | 5| 4| 3| 5| 4| 3| 2| 4| 4| 3| 9| 5| 4| 4| 7| 9| 8| 4| 3| 3| 3| 3| 3| 2| 6|             
                                           | 6| 8| 1| 6| 9| 3| 6| 8| 7| 2| 0| 6| 1| 8| 8| 4| 1| 1| 1| 3| 3| 1| 2| 9| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    3 NG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4  4  4  4  4     4     4  4  4  4  4  4  4     4  4  4  4  4  4  4  4|             
      Cyst                                 |                         2  2  3                          2     2         |             
      Corpus Luteum, Cyst                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Oviduct                                 |                                                                      +   |             
      Inflammation                         |                                                                      3   |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                            3                                             |             
      Inflammation, Suppurative            |          1                                            1  2           3   |             
      Metaplasia, Squamous                 | 1  2  2  1  3  3     2     4        1  2     2        1  3        3      |             
      Cervix, Hyperplasia, Stromal         |                                                                4         |             
      Endometrium, Hyperplasia, Cystic     | 1  2  3  1  2  2     2  4        2        1  2        3     2  2  1      |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Hyperplasia, Stromal                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3  4     2  4     3  4     4     3  3  4  3  3  2  4  4  2     2     4  3|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                               +        +           +                    +|             
      Lumbar, Ectasia                      |                                                    2                     |             
      Lumbar, Hyperplasia, Plasma Cell     |                                        3                                 |             
      Mediastinal, Hemorrhage              |                                                                         3|             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Renal, Ectasia                       |                                                                         3|             
      Renal, Hyperplasia, Histiocytic      |                                                                         2|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                  2                                       |             
      Hyperplasia, Plasma Cell             | 2  2  2        2        3  2        2     2  2  2  2        2           2|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                      3   |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  26                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 5| 4| 7| 5| 6| 6| 7| 4| 5| 2| 4| 5| 3| 6| 3| 7| 7| 7| 7| 7| 7| 2|             
                             DAY ON TEST   | 5| 4| 3| 5| 4| 3| 2| 4| 4| 3| 9| 5| 4| 4| 7| 9| 8| 4| 3| 3| 3| 3| 3| 2| 6|             
                                           | 6| 8| 1| 6| 9| 3| 6| 8| 7| 2| 0| 6| 1| 8| 8| 4| 1| 1| 1| 3| 3| 1| 2| 9| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    3 NG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 1  2  2  1  2     1  2  1  1     2  1  2  3  2  1  3  1  1  1  1  1     3|             
      Pigmentation                         | 1  1  1  1  1  1  1  1  2  1     1  1  1  1  1  1     1  2  2  1  1  3  1|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2  2  4  2     3  3  2  2  4  3  2     4  2     4  3  3  4  2  3  2  4  2|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                  1        3           4                  |             
      Hyperplasia                          |    1  1        1           1                    3     2  2        1      |             
      Inflammation, Granulomatous          |    2                                                                     |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Maxilla, Inflammation, Focal,        |                                                                          |             
          Suppurative                      |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |                                                                          |             
      Mineralization                       |                                                          2               |             
      Glial Cell, Hyperplasia              |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                               2                                          |             
      Infiltration Cellular, Histiocyte    | 2  2  3  2  2  2  2  2  1  3  1  1  1  1     1  2  1  1  2  2  2  1  3   |             
      Inflammation, Granulomatous          |                                                                          |             
      Pigmentation                         |                                           1                              |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     |    1  1     1  1     2     2                    1        2     2     1   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  27                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 5| 4| 7| 5| 6| 6| 7| 4| 5| 2| 4| 5| 3| 6| 3| 7| 7| 7| 7| 7| 7| 2|             
                             DAY ON TEST   | 5| 4| 3| 5| 4| 3| 2| 4| 4| 3| 9| 5| 4| 4| 7| 9| 8| 4| 3| 3| 3| 3| 3| 2| 6|             
                                           | 6| 8| 1| 6| 9| 3| 6| 8| 7| 2| 0| 6| 1| 8| 8| 4| 1| 1| 1| 3| 3| 1| 2| 9| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    3 NG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Retina, Atrophy                      |                   2                                                      |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                         1                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                                          |             
      Casts Protein                        | 1                             2  1                 2                     |             
      Fibrosis                             |                                                                   2      |             
      Inflammation, Chronic Active         |                                           1                              |             
      Mineralization                       | 1     1  1  1  1  1  1     1  1  1  1  1  1  1  1  1           1     1  1|             
      Nephropathy                          |       1     1  1  1              1     1        1     1     1  1  1      |             
      Pelvis, Dilatation                   |                                                                      2   |             
      Pelvis, Inflammation                 |                                                    2                     |             
      Transitional Epithelium, Hyperplasia |                                                    2  3                  |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                    X                     |             
      Hemorrhage                           |                               3                                          |             
      Inflammation                         |          1                    2  1           1     1  2     1            |             
      Transitional Epithelium, Hyperplasia |                                                    3  1                  |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  28                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 2| 3| 7| 7| 7| 7| 5| 4| 7| 7| 5| 6| 2| 6| 7| 7| 6| 5| 4| 6|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 6| 6| 3| 3| 3| 3| 5| 8| 3| 1| 5| 1| 0| 2| 3| 3| 0| 7| 6| 0|             
                                           | 2| 3| 1| 3| 1| 4| 1| 3| 3| 1| 2| 7| 5| 1| 8| 7| 3| 0| 0| 1| 1| 7| 8| 2| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    3 NG/KG                                | 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|             
                                           | 9| 0| 1| 3| 4| 1| 2| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 8| 0| 6| 7| 9| 1| 2|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Inflammation             |             3                                                     2      |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |          X  X                                                            |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |          X           X        X                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                3                                                         |             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                                     X     X                             X|             
      Basophilic Focus, Multiple           |             X        X                                                   |             
      Cholangiofibrosis                    |                                                                          |             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   |                                              X                 X         |             
      Eosinophilic Focus, Multiple         |       X  X              X        X                                       |             
      Fatty Change, Diffuse                |                                                                      1   |             
      Fatty Change, Focal                  |          1  2                                                            |             
      Hematopoietic Cell Proliferation     |                                                          1               |             
      Hepatodiaphragmatic Nodule           |                                                                X         |             
      Inflammation                         | 1  1  1     2  2  1        1  1  1     1  1  1  1  1  1  1  1  1  2  2  1|             
      Mixed Cell Focus                     |       X                                                  X               |             
      Mixed Cell Focus, Multiple           |             X           X  X  X        X                    X            |             
      Necrosis                             |                   3                                                      |             
      Pigmentation                         |       2                                         1           1            |             
      Toxic Hepatopathy                    |                                                                          |             
      Bile Duct, Cyst                      |    3                                                                     |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  29                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 2| 3| 7| 7| 7| 7| 5| 4| 7| 7| 5| 6| 2| 6| 7| 7| 6| 5| 4| 6|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 6| 6| 3| 3| 3| 3| 5| 8| 3| 1| 5| 1| 0| 2| 3| 3| 0| 7| 6| 0|             
                                           | 2| 3| 1| 3| 1| 4| 1| 3| 3| 1| 2| 7| 5| 1| 8| 7| 3| 0| 0| 1| 1| 7| 8| 2| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    3 NG/KG                                | 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|             
                                           | 9| 0| 1| 3| 4| 1| 2| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 8| 0| 6| 7| 9| 1| 2|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Bile Duct, Fibrosis                  |                            2                    2                        |             
      Bile Duct, Hyperplasia               |                                        3                                 |             
      Centrilobular, Degeneration          |                2                                                         |             
      Hepatocyte, Hypertrophy              | 1        2  1     1     1           1                       1           1|             
      Oval Cell, Hyperplasia               |                                        1                                 |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                                    +  +                  |             
      Artery, Inflammation, Chronic Active |                                                    3                     |             
      Fat, Necrosis                        |                                                       3                  |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |                      +                       +              +            |             
      Gingival, Hyperplasia, Squamous      |                      2                       1                           |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                    3                     |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       | 1                                                                        |             
      Hyperplasia, Squamous                | 1                                      2                                 |             
      Inflammation                         |                                                                          |             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Tooth                                   |                      +     +     +              +     +  +  +  +  +      |             
      Peridontal Tissue, Inflammation      |                      1     1     1              1     1  1  2  1  3      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |                                                                      2   |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    1                 1     1                          1  1        1  1   |             
      Artery, Mineralization               |                                                                      2   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  30                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 2| 3| 7| 7| 7| 7| 5| 4| 7| 7| 5| 6| 2| 6| 7| 7| 6| 5| 4| 6|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 6| 6| 3| 3| 3| 3| 5| 8| 3| 1| 5| 1| 0| 2| 3| 3| 0| 7| 6| 0|             
                                           | 2| 3| 1| 3| 1| 4| 1| 3| 3| 1| 2| 7| 5| 1| 8| 7| 3| 0| 0| 1| 1| 7| 8| 2| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    3 NG/KG                                | 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|             
                                           | 9| 0| 1| 3| 4| 1| 2| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 8| 0| 6| 7| 9| 1| 2|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    1     2  2        2  1  2  2  2     3     2  2        2  2           2|             
      Degeneration, Cystic                 |             2        2                 3  3     2                 3      |             
      Hyperplasia                          |    3        3        2  3     2        2  2              2              2|             
      Hypertrophy                          | 1  2  1  1           1  2  2  2     1  3  1  2  2     1  2  3  2  2     2|             
      Necrosis                             |                                                                      3   |             
      Vacuolization Cytoplasmic            |                         1     1           1              2  2            |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia                          |                            1                    2        2               |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    3  3  3           3     2                 2  3     2  3              3|             
      Cyst                                 |                                                                          |             
      Vacuolization Cytoplasmic            |                               2                                          |             
      Pars Distalis, Hyperplasia           |                2        1     2     1  3  3  2        3        2  3      |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      C-Cell, Hyperplasia                  |    3     2                 2           3                 1  1  2         |             
      Follicular Cell, Hyperplasia         |                               1                                          |             
      Follicular Cell, Hypertrophy         |                                     1                                    |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1  3  1     1  2     3  2     2  2  2  1     2  1           2  3     2   |             
      Duct, Cyst                           | 3  2  2        1  2  2  3     2  1     1     3  2           3  3     3  2|             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  31                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 2| 3| 7| 7| 7| 7| 5| 4| 7| 7| 5| 6| 2| 6| 7| 7| 6| 5| 4| 6|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 6| 6| 3| 3| 3| 3| 5| 8| 3| 1| 5| 1| 0| 2| 3| 3| 0| 7| 6| 0|             
                                           | 2| 3| 1| 3| 1| 4| 1| 3| 3| 1| 2| 7| 5| 1| 8| 7| 3| 0| 0| 1| 1| 7| 8| 2| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    3 NG/KG                                | 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|             
                                           | 9| 0| 1| 3| 4| 1| 2| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 8| 0| 6| 7| 9| 1| 2|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4  4  4  4  4  4  4     4  4     4  4     4  4  4  4  4  4  4  4     4|             
      Cyst                                 |       2     2        1           3     2  2     1        1  2  2        2|             
      Corpus Luteum, Cyst                  |                                                                   3      |             
                                           |__________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
      Inflammation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                               3                                          |             
      Inflammation, Suppurative            |                                              1                           |             
      Metaplasia, Squamous                 | 2  2  1     2  2  2  1     1  4     1        2  2     2     1     2     2|             
      Cervix, Hyperplasia, Stromal         |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 1  2  2     3     2  3  1  1        2  3              1  1  3     1     2|             
                                           |__________________________________________________________________________|             
   Vagina                                  | +                                                                        |             
      Hyperplasia, Stromal                 | 3                                                                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3  3           4  3  2  3  3     3  3  3  4  3     4  3  4  2  2  4  4   |             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +                                                                 +      |             
      Lumbar, Ectasia                      |                                                                   2      |             
      Lumbar, Hyperplasia, Plasma Cell     |                                                                   3      |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   | 2                                                                        |             
      Renal, Ectasia                       |                                                                          |             
      Renal, Hyperplasia, Histiocytic      |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                   2                                2                     |             
      Hyperplasia, Plasma Cell             |    2  2  3  2        2              2  2     2  3        2  2  2  3     2|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  32                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 2| 3| 7| 7| 7| 7| 5| 4| 7| 7| 5| 6| 2| 6| 7| 7| 6| 5| 4| 6|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 6| 6| 3| 3| 3| 3| 5| 8| 3| 1| 5| 1| 0| 2| 3| 3| 0| 7| 6| 0|             
                                           | 2| 3| 1| 3| 1| 4| 1| 3| 3| 1| 2| 7| 5| 1| 8| 7| 3| 0| 0| 1| 1| 7| 8| 2| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    3 NG/KG                                | 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|             
                                           | 9| 0| 1| 3| 4| 1| 2| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 8| 0| 6| 7| 9| 1| 2|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2  1  1  1  1  2  2  2  2  1  1  2  1  1  3  1  1  3  2  3  1  2  1  2  1|             
      Pigmentation                         | 1  1  2  1  1  1  1  1  1  2  2  1  1  1  1  1  2     2     3  2  1  4  2|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Atrophy                              |    3  3  3     2  2     2        2     2  3  2        2  2  3  3  3      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |       1                 3     2  1  1  1  3     1        1        1  1   |             
      Inflammation, Granulomatous          |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Maxilla, Inflammation, Focal,        |                                                                          |             
          Suppurative                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |                                                 2                        |             
      Mineralization                       |                                                                          |             
      Glial Cell, Hyperplasia              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    | 2  1  1  2  3        2  1  2  3  1  2  2  2  2  2     2  2  2  2     3  1|             
      Inflammation, Granulomatous          |                                                                          |             
      Pigmentation                         |                                                                          |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     |             2        1     2  2     3  1     2  1           2            |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  33                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 2| 3| 7| 7| 7| 7| 5| 4| 7| 7| 5| 6| 2| 6| 7| 7| 6| 5| 4| 6|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 6| 6| 3| 3| 3| 3| 5| 8| 3| 1| 5| 1| 0| 2| 3| 3| 0| 7| 6| 0|             
                                           | 2| 3| 1| 3| 1| 4| 1| 3| 3| 1| 2| 7| 5| 1| 8| 7| 3| 0| 0| 1| 1| 7| 8| 2| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    3 NG/KG                                | 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8|             
                                           | 9| 0| 1| 3| 4| 1| 2| 4| 5| 1| 3| 4| 5| 1| 2| 3| 4| 5| 8| 0| 6| 7| 9| 1| 2|             
 __________________________________________|__________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Retina, Atrophy                      |       2  3                 2     2                                       |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |             1                                                     2      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                             X            |             
      Casts Protein                        |                                              1                           |             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       | 1  1     1  1     1  1  1  1  1     1  1     1  1        1     1     3  1|             
      Nephropathy                          |    2  1  1  1     1  1     1  1           1     1  1     1  1            |             
      Pelvis, Dilatation                   |                                                                          |             
      Pelvis, Inflammation                 |                                                                          |             
      Transitional Epithelium, Hyperplasia |                      1           2                          1        1   |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation                         |             1           1              2                                 |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  34                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 7|                                                              |            |
                             DAY ON TEST   | 0| 5| 3| 3|                                                              |            |
                                           | 4| 6| 3| 1|                                                              |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0|                                                              |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0|                                                              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1|                                                              |      A     |
    3 NG/KG                                | 8| 8| 9| 9|                                                              |      L     |
                                           | 3| 4| 7| 8|                                                              |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +                                                               |  54        |
      Muscularis, Inflammation             |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  M  +  +                                                               |  53        |
      Parasite Metazoan                    |                                                                          |      2     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +                                                               |  54        |
      Parasite Metazoan                    |                                                                          |      4     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  M  +  +                                                               |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +                                                               |  54        |
      Ulcer                                |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +                                                               |  54        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  M  +  +                                                               |  53        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +                                                               |  54        |
      Angiectasis                          |                                                                          |      1  1.0|
      Basophilic Focus                     |                                                                          |      6     |
      Basophilic Focus, Multiple           | X                                                                        |      3     |
      Cholangiofibrosis                    |                                                                          |      1  1.0|
      Clear Cell Focus                     |                                                                          |      1     |
      Eosinophilic Focus                   |                                                                          |      6     |
      Eosinophilic Focus, Multiple         |                                                                          |      8     |
      Fatty Change, Diffuse                |                                                                          |      2  1.0|
      Fatty Change, Focal                  | 1     1                                                                  |      6  1.5|
      Hematopoietic Cell Proliferation     |       1                                                                  |      2  1.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      2     |
      Inflammation                         | 1  1  1  1                                                               |     46  1.2|
      Mixed Cell Focus                     |       X                                                                  |      8     |
      Mixed Cell Focus, Multiple           |          X                                                               |     11     |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  35                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 7|                                                              |            |
                             DAY ON TEST   | 0| 5| 3| 3|                                                              |            |
                                           | 4| 6| 3| 1|                                                              |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0|                                                              |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0|                                                              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1|                                                              |      A     |
    3 NG/KG                                | 8| 8| 9| 9|                                                              |      L     |
                                           | 3| 4| 7| 8|                                                              |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Necrosis                             |    3                                                                     |      4  2.3|
      Pigmentation                         | 1  2                                                                     |      9  1.2|
      Toxic Hepatopathy                    |                                                                          |      2  1.0|
      Bile Duct, Cyst                      |                                                                          |      1  3.0|
      Bile Duct, Fibrosis                  |                                                                          |      2  2.0|
      Bile Duct, Hyperplasia               |                                                                          |      4  1.5|
      Centrilobular, Degeneration          |                                                                          |      2  2.0|
      Hepatocyte, Hypertrophy              |    1                                                                     |     19  1.2|
      Oval Cell, Hyperplasia               |                                                                          |      4  1.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Artery, Inflammation, Chronic Active |                                                                          |      1  3.0|
      Fat, Necrosis                        |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |                                                                          |   9        |
      Gingival, Hyperplasia, Squamous      |                                                                          |      7  1.4|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +                                                               |  54        |
      Acinus, Atrophy                      |          2                                                               |      2  1.5|
      Artery, Inflammation, Chronic Active |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +                                                               |  54        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +                                                               |  54        |
      Hyperkeratosis                       |                                                                          |      1  1.0|
      Hyperplasia, Squamous                |                                                                          |      4  1.5|
      Inflammation                         |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +                                                               |  54        |
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                                                                          |  16        |
      Peridontal Tissue, Inflammation      |                                                                          |     16  1.2|
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  36                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 7|                                                              |            |
                             DAY ON TEST   | 0| 5| 3| 3|                                                              |            |
                                           | 4| 6| 3| 1|                                                              |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0|                                                              |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0|                                                              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1|                                                              |      A     |
    3 NG/KG                                | 8| 8| 9| 9|                                                              |      L     |
                                           | 3| 4| 7| 8|                                                              |            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +                                                               |  54        |
      Aorta, Mineralization                |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +  +                                                               |  54        |
      Cardiomyopathy                       |       1                                                                  |     12  1.0|
      Artery, Mineralization               |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +                                                               |  54        |
      Angiectasis                          |          1                                                               |     21  1.9|
      Degeneration, Cystic                 |          1                                                               |     15  2.1|
      Hyperplasia                          |          2                                                               |     16  2.2|
      Hypertrophy                          | 1     4  2                                                               |     43  2.0|
      Necrosis                             |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic            |                                                                          |      7  1.3|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +                                                               |  54        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hyperplasia                          |          2                                                               |     10  2.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +                                                               |  54        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  M  +                                                               |  47        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +                                                               |  54        |
      Angiectasis                          | 3     1                                                                  |     18  2.6|
      Cyst                                 |                                                                          |      1  3.0|
      Vacuolization Cytoplasmic            |                                                                          |      3  1.7|
      Pars Distalis, Hyperplasia           |    2     2                                                               |     19  2.1|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +                                                               |  54        |
      Angiectasis                          |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  37                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 7|                                                              |            |
                             DAY ON TEST   | 0| 5| 3| 3|                                                              |            |
                                           | 4| 6| 3| 1|                                                              |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0|                                                              |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0|                                                              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1|                                                              |      A     |
    3 NG/KG                                | 8| 8| 9| 9|                                                              |      L     |
                                           | 3| 4| 7| 8|                                                              |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      C-Cell, Hyperplasia                  |                                                                          |     17  2.2|
      Follicular Cell, Hyperplasia         |                                                                          |      2  2.0|
      Follicular Cell, Hypertrophy         |                                                                          |      4  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  M  +  +                                                               |  52        |
      Inflammation                         | 2     2  1                                                               |     40  1.7|
      Duct, Cyst                           | 3     2  2                                                               |     37  2.1|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  M  +  +                                                               |  53        |
      Atrophy                              | 4     4  4                                                               |     46  4.0|
      Cyst                                 |                                                                          |     16  1.9|
      Corpus Luteum, Cyst                  |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |   1        |
      Inflammation                         |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  M  +  +                                                               |  53        |
      Inflammation, Chronic Active         |                                                                          |      2  3.0|
      Inflammation, Suppurative            |          3                                                               |      6  1.8|
      Metaplasia, Squamous                 |          2                                                               |     31  2.0|
      Cervix, Hyperplasia, Stromal         |                                                                          |      1  4.0|
      Endometrium, Hyperplasia, Cystic     | 2     2  2                                                               |     33  1.9|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
      Hyperplasia, Stromal                 |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +                                                               |  54        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  38                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 7|                                                              |            |
                             DAY ON TEST   | 0| 5| 3| 3|                                                              |            |
                                           | 4| 6| 3| 1|                                                              |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0|                                                              |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0|                                                              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1|                                                              |      A     |
    3 NG/KG                                | 8| 8| 9| 9|                                                              |      L     |
                                           | 3| 4| 7| 8|                                                              |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Hyperplasia                          |    4  3  3                                                               |     41  3.2|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   6        |
      Lumbar, Ectasia                      |                                                                          |      2  2.0|
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |      2  3.0|
      Mediastinal, Hemorrhage              |                                                                          |      1  3.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  2.0|
      Renal, Ectasia                       |                                                                          |      1  3.0|
      Renal, Hyperplasia, Histiocytic      |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +                                                               |  54        |
      Hyperplasia, Lymphoid                |                                                                          |      3  2.0|
      Hyperplasia, Plasma Cell             | 2  2  2  2                                                               |     31  2.1|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  M  +  +                                                               |  53        |
      Atrophy                              |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +                                                               |  54        |
      Hematopoietic Cell Proliferation     |    2  2  1                                                               |     50  1.6|
      Pigmentation                         | 2     2  1                                                               |     49  1.4|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +                                                               |  52        |
      Atrophy                              | 2  3  2  3                                                               |     41  2.7|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +                                                               |  54        |
      Cyst                                 |                                                                          |      3  2.7|
      Hyperplasia                          | 1     1                                                                  |     21  1.4|
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +                                                               |  54        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  39                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 7|                                                              |            |
                             DAY ON TEST   | 0| 5| 3| 3|                                                              |            |
                                           | 4| 6| 3| 1|                                                              |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0|                                                              |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0|                                                              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1|                                                              |      A     |
    3 NG/KG                                | 8| 8| 9| 9|                                                              |      L     |
                                           | 3| 4| 7| 8|                                                              |            |
 _____________________________________________________________________________________________________________________|____________|
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +  +                                                               |  54        |
      Maxilla, Inflammation, Focal,        |                                                                          |            |
          Suppurative                      |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +  +                                                               |  54        |
      Hydrocephalus                        |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  2.0|
      Glial Cell, Hyperplasia              |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +                                                               |  54        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    | 2  2                                                                     |     46  1.8|
      Inflammation, Granulomatous          |       2                                                                  |      1  2.0|
      Pigmentation                         |                                                                          |      1  1.0|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Bronchiolar                     |                                                                          |     19  1.6|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +  +                                                               |  54        |
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +                                                               |  54        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +  +                                                               |  54        |
      Retina, Atrophy                      |                                                                          |      5  2.2|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +                                                               |  54        |
      Inflammation                         |                                                                          |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  40                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 7|                                                              |            |
                             DAY ON TEST   | 0| 5| 3| 3|                                                              |            |
                                           | 4| 6| 3| 1|                                                              |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0|                                                              |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0|                                                              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1|                                                              |      A     |
    3 NG/KG                                | 8| 8| 9| 9|                                                              |      L     |
                                           | 3| 4| 7| 8|                                                              |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +                                                               |  54        |
      Calculus Micro Observation Only      |                                                                          |      1     |
      Casts Protein                        |                                                                          |      5  1.4|
      Fibrosis                             |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Mineralization                       | 1  1     1                                                               |     39  1.1|
      Nephropathy                          |       2  1                                                               |     26  1.1|
      Pelvis, Dilatation                   |                                                                          |      1  2.0|
      Pelvis, Inflammation                 |                                                                          |      1  2.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      6  1.7|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  M  +  +                                                               |  53        |
      Calculus Micro Observation Only      |                                                                          |      1     |
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation                         |                                                                          |     10  1.3|
      Transitional Epithelium, Hyperplasia |                                                                          |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  41                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 6| 0| 6| 7| 7| 7| 7| 6| 7| 1| 7| 7| 6| 4| 5| 6| 7| 7| 3| 7| 6| 5|             
                             DAY ON TEST   | 7| 3| 3| 4| 4| 5| 3| 3| 3| 3| 7| 2| 7| 3| 3| 1| 2| 5| 9| 3| 3| 4| 2| 1| 7|             
                                           | 8| 3| 1| 5| 7| 0| 3| 1| 3| 1| 6| 8| 7| 1| 2| 4| 9| 0| 7| 2| 1| 4| 0| 3| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10 NG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 4|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Perforation                          |             X                                                            |             
      Muscularis, Inflammation             |                                                                          |             
      Periesophageal Tissue, Inflammation  |             2                                                            |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                   1                                                      |             
      Basophilic Focus                     |                                        X        X        X  X            |             
      Basophilic Focus, Multiple           |    X                          X                       X           X      |             
      Cholangiofibrosis                    |                   2                                                      |             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   | X              X        X        X           X     X                     |             
      Eosinophilic Focus, Multiple         |    X  X  X        X           X                          X        X     X|             
      Fatty Change, Diffuse                | 1  1  1                                            1              1      |             
      Fatty Change, Focal                  |                         1        3                                       |             
      Hematopoietic Cell Proliferation     |                                  1                                       |             
      Inflammation                         | 1  1  1  1  1  1  1  1  1  1  1     1  1  1  1  1  1  1  1  1  1  1  1  1|             
      Mixed Cell Focus                     |                               X  X        X              X              X|             
      Mixed Cell Focus, Multiple           | X  X              X  X  X  X           X     X              X        X   |             
      Necrosis                             |             2                    1                 3                     |             
      Pigmentation                         |    1  1        2  2  1  1  1  1  1     1  1  1  2  2  3  2        1     1|             
      Toxic Hepatopathy                    | 1  1              1     1     1  2                                       |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  42                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 6| 0| 6| 7| 7| 7| 7| 6| 7| 1| 7| 7| 6| 4| 5| 6| 7| 7| 3| 7| 6| 5|             
                             DAY ON TEST   | 7| 3| 3| 4| 4| 5| 3| 3| 3| 3| 7| 2| 7| 3| 3| 1| 2| 5| 9| 3| 3| 4| 2| 1| 7|             
                                           | 8| 3| 1| 5| 7| 0| 3| 1| 3| 1| 6| 8| 7| 1| 2| 4| 9| 0| 7| 2| 1| 4| 0| 3| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10 NG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 4|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Bile Duct, Cyst                      |                                  2                                       |             
      Bile Duct, Hyperplasia               |                               1           1                       1      |             
      Hepatocyte, Hypertrophy              | 1     1  1              2  1  1  1     1  1                             1|             
      Hepatocyte, Multinucleated           |    1  1        2              1           2        1  1                 1|             
      Oval Cell, Hyperplasia               | 1                             1                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +              +              +           +  +     +  +              +|             
      Gingival, Hyperplasia, Squamous      | 1  2              2              1           2        1  2              1|             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Acinus, Atrophy                      |                                                                          |             
      Artery, Inflammation, Chronic Active |       2                                                                  |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst, Squamous                       |                                                                          |             
      Erosion                              |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Squamous                |       2                                                                  |             
      Inflammation                         |                                                                          |             
      Mineralization                       |                               2                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   |    +              +                          +  +  +        +           +|             
      Peridontal Tissue, Inflammation      |    1              1                          1  1  1        1           1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thrombosis                           |       4                                                                  |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |       1           1        1  1        1     1  1  1  1           1  1   |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  43                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 6| 0| 6| 7| 7| 7| 7| 6| 7| 1| 7| 7| 6| 4| 5| 6| 7| 7| 3| 7| 6| 5|             
                             DAY ON TEST   | 7| 3| 3| 4| 4| 5| 3| 3| 3| 3| 7| 2| 7| 3| 3| 1| 2| 5| 9| 3| 3| 4| 2| 1| 7|             
                                           | 8| 3| 1| 5| 7| 0| 3| 1| 3| 1| 6| 8| 7| 1| 2| 4| 9| 0| 7| 2| 1| 4| 0| 3| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10 NG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 4|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    2     2              1     1        2           2  2  2               |             
      Atrophy                              |       1                                                                  |             
      Degeneration, Cystic                 |       3  3        3  1        1  2        3              3  2            |             
      Hyperplasia                          | 2     2           3     3        2     3  3           2  2  2  2     2   |             
      Hypertrophy                          | 2  2  3  3     2  2  3  2  2  2  3     1  2  2     3  2  2  2     2  2  1|             
      Necrosis                             |                      1                                            2      |             
      Vacuolization Cytoplasmic            | 1        1                 1     3        2                 2            |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      2                                                   |             
      Hyperplasia                          |       1           2        1                 2        2     2            |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                4                                                         |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  M  +  +  M  +  +  +  +|             
      Fibrosis                             |                                                                          |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      1  2  3  3  2     3  3  2     1  2  3  1     1      |             
      Cytoplasmic Alteration               |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Pars Distalis, Hyperplasia           | 1  3  2                 2                    3                    3  1  2|             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                            1                                             |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      C-Cell, Hyperplasia                  |       3  1        2     2        2  3  2  2     2     3     2            |             
      Follicular Cell, Hypertrophy         |                            3                    2                       2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  44                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 6| 0| 6| 7| 7| 7| 7| 6| 7| 1| 7| 7| 6| 4| 5| 6| 7| 7| 3| 7| 6| 5|             
                             DAY ON TEST   | 7| 3| 3| 4| 4| 5| 3| 3| 3| 3| 7| 2| 7| 3| 3| 1| 2| 5| 9| 3| 3| 4| 2| 1| 7|             
                                           | 8| 3| 1| 5| 7| 0| 3| 1| 3| 1| 6| 8| 7| 1| 2| 4| 9| 0| 7| 2| 1| 4| 0| 3| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10 NG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 4|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Basal Cell              |                                                                          |             
      Inflammation                         | 1  2  2           2  1  1     1     1        1  3  2  1  3  1     1  2  1|             
      Duct, Cyst                           | 2  2  3  2     2  3  1  1     2     2        2  1  3     1        3  2   |             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4  4  4     4  3  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4  4|             
      Cyst                                 | 3                    2                       2  2     3                  |             
      Fibrosis                             |                                                                          |             
                                           |__________________________________________________________________________|             
   Oviduct                                 |                         +                                                |             
      Inflammation                         |                         2                                                |             
      Epithelium, Hyperplasia              |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                         2|             
      Inflammation, Suppurative            | 3                    4  2                    4  1  4  3                  |             
      Metaplasia, Squamous                 | 4  2  2  2        2  2  3     1     2     3  3     4  3        2  1     4|             
      Ulcer                                |                                                                          |             
      Cervix, Hyperplasia, Stromal         |                   4                                                      |             
      Endometrium, Adenomyosis             |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |    2  1  2        2  2     3  2        2                 3  3     2  1  4|             
      Serosa, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3        4  3     2  4     3  2  3  3        3  4  3  4     2  3  3  4  4|             
                                           |__________________________________________________________________________|             
   Lymph Node                              | +                                +                                       |             
      Lumbar, Ectasia                      | 3                                                                        |             
      Mediastinal, Hyperplasia, Histiocytic|                                  2                                       |             
      Mediastinal, Pigmentation            |                                  2                                       |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  45                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 6| 0| 6| 7| 7| 7| 7| 6| 7| 1| 7| 7| 6| 4| 5| 6| 7| 7| 3| 7| 6| 5|             
                             DAY ON TEST   | 7| 3| 3| 4| 4| 5| 3| 3| 3| 3| 7| 2| 7| 3| 3| 1| 2| 5| 9| 3| 3| 4| 2| 1| 7|             
                                           | 8| 3| 1| 5| 7| 0| 3| 1| 3| 1| 6| 8| 7| 1| 2| 4| 9| 0| 7| 2| 1| 4| 0| 3| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10 NG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 4|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Hyperplasia, Lymphoid                |             2                                                            |             
      Hyperplasia, Plasma Cell             |    3           2  2  2  2           2     3  3     2  2  2               |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 1  1  1  2  1     1  1  1  1  1  3     1  1  1  2        1  1     2  2  1|             
      Necrosis                             |                                                                          |             
      Pigmentation                         | 1  1  1  1  2  2  2  1  1  2  2  1  2  2  2  2  1  1  2  2  1  1  1  1  1|             
      Lymphoid Follicle, Atrophy           |             2                                                            |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4  3  3  2     2  3  2  3     2     3  3  3  3  4  4  3        4  3  3|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    1  1  1           1     2  1  3     2  2  1              1            |             
      Inflammation, Granulomatous          |                   2                                                      |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis                             |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  46                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 6| 0| 6| 7| 7| 7| 7| 6| 7| 1| 7| 7| 6| 4| 5| 6| 7| 7| 3| 7| 6| 5|             
                             DAY ON TEST   | 7| 3| 3| 4| 4| 5| 3| 3| 3| 3| 7| 2| 7| 3| 3| 1| 2| 5| 9| 3| 3| 4| 2| 1| 7|             
                                           | 8| 3| 1| 5| 7| 0| 3| 1| 3| 1| 6| 8| 7| 1| 2| 4| 9| 0| 7| 2| 1| 4| 0| 3| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10 NG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 4|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
      Hydrocephalus                        |                                                                          |             
      Mineralization                       |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
      Cerebellum, Necrosis                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                              +                           |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                              +                           |             
      Gliosis                              |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |             2                                                            |             
      Edema                                |                                                 2     2                  |             
      Infiltration Cellular, Histiocyte    |    1  2  2     2  2  1  1     2  3     1  3        1     2  2  1  1  1  2|             
      Inflammation, Granulomatous          |                                                       3                  |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     |       1  2     1  2     1        1     1  2              2  1        1  2|             
      Bronchiole, Dilatation               |                                                       2                  |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Turbinate, Septum, Inflammation      |                                                       2                  |             
      Turbinate, Respiratory Epithelium,   |                                                                          |             
           Hyperplasia                     |                                                       2                  |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |                                                       +                  |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cornea, Inflammation, Suppurative    |                                                                          |             
      Retina, Atrophy                      |                   2                    2                                 |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  47                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 6| 0| 6| 7| 7| 7| 7| 6| 7| 1| 7| 7| 6| 4| 5| 6| 7| 7| 3| 7| 6| 5|             
                             DAY ON TEST   | 7| 3| 3| 4| 4| 5| 3| 3| 3| 3| 7| 2| 7| 3| 3| 1| 2| 5| 9| 3| 3| 4| 2| 1| 7|             
                                           | 8| 3| 1| 5| 7| 0| 3| 1| 3| 1| 6| 8| 7| 1| 2| 4| 9| 0| 7| 2| 1| 4| 0| 3| 8|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10 NG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 4| 4| 4|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 1| 3| 4| 5| 1| 2| 4|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                                          |             
      Casts Protein                        |                                                                          |             
      Infarct                              |       3                                                                  |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |    1     1  1     1  1  1     1  1     1  1        1  1  1     1  1  1  1|             
      Nephropathy                          | 1  1  2           1     1  1           1  1  1        1  1  3     1      |             
      Papilla, Necrosis                    |                                                                          |             
      Pelvis, Dilatation                   |                                                 3                        |             
      Pelvis, Inflammation                 |                      2                                                   |             
      Transitional Epithelium, Hyperplasia |       2           2  2                                                   |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                      3                       1                           |             
      Transitional Epithelium, Hyperplasia |                      2                                                   |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  48                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 0| 7| 6| 7| 7| 6| 5| 7| 7| 6| 7| 7| 3| 5| 7| 2| 7| 7| 7|             
                             DAY ON TEST   | 3| 7| 3| 3| 3| 3| 5| 1| 2| 3| 3| 0| 7| 3| 3| 5| 3| 3| 4| 7| 3| 4| 2| 3| 1|             
                                           | 1| 8| 2| 1| 2| 2| 4| 8| 6| 2| 2| 4| 8| 1| 1| 9| 1| 2| 8| 8| 3| 0| 4| 3| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10 NG/KG                               | 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 5| 6| 7| 9| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 0| 2| 3| 4| 2| 4| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                   4      |             
      Perforation                          |                   X                                                      |             
      Muscularis, Inflammation             |                                        2                                 |             
      Periesophageal Tissue, Inflammation  |                   3                                                      |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                           X                              |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                   1                                                      |             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |       X     X        X                                            X      |             
      Basophilic Focus, Multiple           |                                                 X                        |             
      Cholangiofibrosis                    |                                                    1                     |             
      Clear Cell Focus                     |                                        X                                 |             
      Eosinophilic Focus                   |                                           X                              |             
      Eosinophilic Focus, Multiple         | X                                   X              X                 X  X|             
      Fatty Change, Diffuse                |                1        2              1        1                 1  1   |             
      Fatty Change, Focal                  | 1                                                                       1|             
      Hematopoietic Cell Proliferation     |    1                                                                     |             
      Inflammation                         | 1  1  2  1  1  1  1  2     1  1     1  1  1  1  2  1  1     1  1  1  1   |             
      Mixed Cell Focus                     |             X              X                                            X|             
      Mixed Cell Focus, Multiple           | X        X     X     X        X     X  X  X     X           X        X   |             
      Necrosis                             |       2                                                                  |             
      Pigmentation                         | 2  2  1        1     2  2  1           1  1  1  2           1     1  2   |             
      Toxic Hepatopathy                    | 1     2                                                                  |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  49                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 0| 7| 6| 7| 7| 6| 5| 7| 7| 6| 7| 7| 3| 5| 7| 2| 7| 7| 7|             
                             DAY ON TEST   | 3| 7| 3| 3| 3| 3| 5| 1| 2| 3| 3| 0| 7| 3| 3| 5| 3| 3| 4| 7| 3| 4| 2| 3| 1|             
                                           | 1| 8| 2| 1| 2| 2| 4| 8| 6| 2| 2| 4| 8| 1| 1| 9| 1| 2| 8| 8| 3| 0| 4| 3| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10 NG/KG                               | 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 5| 6| 7| 9| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 0| 2| 3| 4| 2| 4| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Bile Duct, Cyst                      |                                                                      2   |             
      Bile Duct, Hyperplasia               |       2                                            1              1  1   |             
      Hepatocyte, Hypertrophy              | 2  2        1     1                 1     1     2                       1|             
      Hepatocyte, Multinucleated           | 1                    1                       1  2           1        1   |             
      Oval Cell, Hyperplasia               |       2                                                                  |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +           +                             +  +              +         |             
      Gingival, Hyperplasia, Squamous      | 2              2                             1  3              1         |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 1        2                                                               |             
      Acinus, Atrophy                      | 1        2                             2                                 |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                   3        1                                             |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst, Squamous                       |          2                                                               |             
      Erosion                              |    2                                                                     |             
      Hyperkeratosis                       |                   1                                                      |             
      Hyperplasia, Squamous                |                   1           1                                         3|             
      Inflammation                         |    1                                                                    2|             
      Mineralization                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                                 X                        |             
                                           |__________________________________________________________________________|             
   Tooth                                   | +  +  +              +                                                   |             
      Peridontal Tissue, Inflammation      | 1  1  3              1                                                   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thrombosis                           |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1     1     1  1     1                    1  1                    1  1  1|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  50                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 0| 7| 6| 7| 7| 6| 5| 7| 7| 6| 7| 7| 3| 5| 7| 2| 7| 7| 7|             
                             DAY ON TEST   | 3| 7| 3| 3| 3| 3| 5| 1| 2| 3| 3| 0| 7| 3| 3| 5| 3| 3| 4| 7| 3| 4| 2| 3| 1|             
                                           | 1| 8| 2| 1| 2| 2| 4| 8| 6| 2| 2| 4| 8| 1| 1| 9| 1| 2| 8| 8| 3| 0| 4| 3| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10 NG/KG                               | 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 5| 6| 7| 9| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 0| 2| 3| 4| 2| 4| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2        2  1  1     2        1                    2        2        1  1|             
      Atrophy                              |                                                    2        1  2         |             
      Degeneration, Cystic                 | 1     1        2     3  2           2  2  1        2              2  3  3|             
      Hyperplasia                          | 2        2     3        2     3           3                              |             
      Hypertrophy                          | 2  1  2  1  1  2     3     2  1  2  3  4  2  2  2  3  1  1  1     2  3  4|             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            | 1              1              1                                         1|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                 2                        |             
      Hyperplasia                          | 1     2  3                       2        2  2  2           1     3  2   |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                  3                                       |             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    3  3        2     3     2              1  3              3     2  2  3|             
      Cytoplasmic Alteration               |                               1                                          |             
      Vacuolization Cytoplasmic            |             2                                                            |             
      Pars Distalis, Hyperplasia           | 3        2  3           3     1        2  3        2                     |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Inflammation, Chronic Active         |                   2                                                      |             
      Inflammation, Suppurative            |                                                                          |             
      C-Cell, Hyperplasia                  | 3     2     1  2           3                 1  2  2        2        3   |             
      Follicular Cell, Hypertrophy         | 1                                                                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  51                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 0| 7| 6| 7| 7| 6| 5| 7| 7| 6| 7| 7| 3| 5| 7| 2| 7| 7| 7|             
                             DAY ON TEST   | 3| 7| 3| 3| 3| 3| 5| 1| 2| 3| 3| 0| 7| 3| 3| 5| 3| 3| 4| 7| 3| 4| 2| 3| 1|             
                                           | 1| 8| 2| 1| 2| 2| 4| 8| 6| 2| 2| 4| 8| 1| 1| 9| 1| 2| 8| 8| 3| 0| 4| 3| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10 NG/KG                               | 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 5| 6| 7| 9| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 0| 2| 3| 4| 2| 4| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Basal Cell              |          2                                                               |             
      Inflammation                         |    1  2     3  3     1     1  2     3     1  3  2     2     1        1  1|             
      Duct, Cyst                           | 3  3  4     3  3  2  1  3  1  3  2  1  3  2  3  3  2  2  2  2        1  2|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4  4  4  4  4     4  4  4  4  4  4  4  4  4  4     4  4  4  4  4  4  4|             
      Cyst                                 | 3     2     3              2  3     2                       2            |             
      Fibrosis                             |       3                                                                  |             
                                           |__________________________________________________________________________|             
   Oviduct                                 |                            +                                             |             
      Inflammation                         |                                                                          |             
      Epithelium, Hyperplasia              |                            2                                             |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 3                                      3                                 |             
      Inflammation, Suppurative            |                1              2     1        2        2                  |             
      Metaplasia, Squamous                 |    1                       3  3     2  4  1  3  3     3  2        3      |             
      Ulcer                                |                                        2                                 |             
      Cervix, Hyperplasia, Stromal         |                                                                          |             
      Endometrium, Adenomyosis             |                                           3                              |             
      Endometrium, Hyperplasia, Cystic     |    1  1  3  3  3     1  2  1  3     1     2  2  2  1  2  2  4     2  3  1|             
      Serosa, Inflammation, Chronic Active |                                           3                              |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                                                   +      |             
      Cyst                                 |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    3  4           3                 4     3  4     3  3  2     3  3     3|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                         +                                                |             
      Lumbar, Ectasia                      |                                                                          |             
      Mediastinal, Hyperplasia, Histiocytic|                                                                          |             
      Mediastinal, Pigmentation            |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  52                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 0| 7| 6| 7| 7| 6| 5| 7| 7| 6| 7| 7| 3| 5| 7| 2| 7| 7| 7|             
                             DAY ON TEST   | 3| 7| 3| 3| 3| 3| 5| 1| 2| 3| 3| 0| 7| 3| 3| 5| 3| 3| 4| 7| 3| 4| 2| 3| 1|             
                                           | 1| 8| 2| 1| 2| 2| 4| 8| 6| 2| 2| 4| 8| 1| 1| 9| 1| 2| 8| 8| 3| 0| 4| 3| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10 NG/KG                               | 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 5| 6| 7| 9| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 0| 2| 3| 4| 2| 4| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Hyperplasia, Lymphoid                |                                                       2                  |             
      Hyperplasia, Plasma Cell             |       4                                2  2  3     3     2  2     2  3  2|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 1  2  1  1  2  1           1        2     2  1  1  1     1  1     2  1  1|             
      Necrosis                             |                         3                                                |             
      Pigmentation                         | 1  2  1  1  1  2  1  2     1  2     1  2  1  2  2  2  2  1  2     1  1  1|             
      Lymphoid Follicle, Atrophy           |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Atrophy                              | 4  4     4  4  3  4  3     3  3  4  2  3  3  3  4  2  2  2  2     4  3   |             
      Hemorrhage                           |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 1  2        2     1  1              1     2     1  2        2     1     1|             
      Inflammation, Granulomatous          |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Squamous                |                                           2                              |             
      Inflammation, Chronic Active         |                   3                       3                              |             
      Necrosis                             |                   3                                                      |             
      Ulcer                                |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                         3                                                |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  53                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 0| 7| 6| 7| 7| 6| 5| 7| 7| 6| 7| 7| 3| 5| 7| 2| 7| 7| 7|             
                             DAY ON TEST   | 3| 7| 3| 3| 3| 3| 5| 1| 2| 3| 3| 0| 7| 3| 3| 5| 3| 3| 4| 7| 3| 4| 2| 3| 1|             
                                           | 1| 8| 2| 1| 2| 2| 4| 8| 6| 2| 2| 4| 8| 1| 1| 9| 1| 2| 8| 8| 3| 0| 4| 3| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10 NG/KG                               | 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 5| 6| 7| 9| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 0| 2| 3| 4| 2| 4| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
      Hydrocephalus                        |                                                                          |             
      Mineralization                       |                                                             2            |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
      Cerebellum, Necrosis                 |                         3                                                |             
                                           |__________________________________________________________________________|             
   Peripheral Nerve                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Gliosis                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                   3                                                      |             
      Edema                                |                                                                          |             
      Infiltration Cellular, Histiocyte    | 1  1  1  2  2  2     1  2  2  2  1  2  2  2  3  2  2  2  2  3     2  2  3|             
      Inflammation, Granulomatous          |                                           2                              |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     | 1  1     2  2  2        1  1  2     1  1  2  2  2  1     1  3     1  2  2|             
      Bronchiole, Dilatation               |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Turbinate, Septum, Inflammation      |                                                                          |             
      Turbinate, Respiratory Epithelium,   |                                                                          |             
           Hyperplasia                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |                                           +                              |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cornea, Inflammation, Suppurative    |       1                                                                  |             
      Retina, Atrophy                      |       2     3                                               2            |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |       2                    1                                             |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  54                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 7| 7| 0| 7| 6| 7| 7| 6| 5| 7| 7| 6| 7| 7| 3| 5| 7| 2| 7| 7| 7|             
                             DAY ON TEST   | 3| 7| 3| 3| 3| 3| 5| 1| 2| 3| 3| 0| 7| 3| 3| 5| 3| 3| 4| 7| 3| 4| 2| 3| 1|             
                                           | 1| 8| 2| 1| 2| 2| 4| 8| 6| 2| 2| 4| 8| 1| 1| 9| 1| 2| 8| 8| 3| 0| 4| 3| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10 NG/KG                               | 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 5| 6| 7| 9| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6| 8| 0| 2| 3| 4| 2| 4| 6| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |    X                                                                     |             
      Casts Protein                        | 1                                                     1                  |             
      Infarct                              |                                                                          |             
      Inflammation, Suppurative            |                   3                          1                           |             
      Mineralization                       |       1  1     1     1     1  1  1  1        1     1                 1  1|             
      Nephropathy                          | 1  1  2  1  1  1     1        1        1  3  1  1  1     1  2     2  1   |             
      Papilla, Necrosis                    |                   3                                                      |             
      Pelvis, Dilatation                   |                                                                          |             
      Pelvis, Inflammation                 |                                                                          |             
      Transitional Epithelium, Hyperplasia |       2                                1  2     2                    1   |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |             1                       1                                    |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  55                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 6| 6|                                                                 |            |
                             DAY ON TEST   | 3| 3| 5|                                                                 |            |
                                           | 6| 5| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 2| 2| 2|                                                                 |      A     |
    10 NG/KG                               | 9| 9| 9|                                                                 |      L     |
                                           | 0| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  53        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Perforation                          |                                                                          |      2     |
      Muscularis, Inflammation             |                                                                          |      1  2.0|
      Periesophageal Tissue, Inflammation  | 3                                                                        |      3  2.7|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  53        |
      Parasite Metazoan                    |                                                                          |      1     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  53        |
      Epithelium, Hyperplasia              |                                                                          |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |      1  1.0|
      Basophilic Focus                     |                                                                          |      8     |
      Basophilic Focus, Multiple           |                                                                          |      5     |
      Cholangiofibrosis                    |                                                                          |      2  1.5|
      Clear Cell Focus                     |                                                                          |      1     |
      Eosinophilic Focus                   |                                                                          |      7     |
      Eosinophilic Focus, Multiple         |    X                                                                     |     14     |
      Fatty Change, Diffuse                | 1                                                                        |     12  1.1|
      Fatty Change, Focal                  |                                                                          |      4  1.5|
      Hematopoietic Cell Proliferation     |                                                                          |      2  1.0|
      Inflammation                         |    1  1                                                                  |     47  1.1|
      Mixed Cell Focus                     |                                                                          |      8     |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  56                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 6| 6|                                                                 |            |
                             DAY ON TEST   | 3| 3| 5|                                                                 |            |
                                           | 6| 5| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 2| 2| 2|                                                                 |      A     |
    10 NG/KG                               | 9| 9| 9|                                                                 |      L     |
                                           | 0| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Mixed Cell Focus, Multiple           |                                                                          |     21     |
      Necrosis                             |                                                                          |      4  2.0|
      Pigmentation                         |    2  2                                                                  |     34  1.4|
      Toxic Hepatopathy                    |                                                                          |      8  1.3|
      Bile Duct, Cyst                      |                                                                          |      2  2.0|
      Bile Duct, Hyperplasia               |                                                                          |      7  1.1|
      Hepatocyte, Hypertrophy              |    1                                                                     |     19  1.2|
      Hepatocyte, Multinucleated           |    1  1                                                                  |     16  1.2|
      Oval Cell, Hyperplasia               |                                                                          |      3  1.3|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |       +                                                                  |  16        |
      Gingival, Hyperplasia, Squamous      |       2                                                                  |     14  1.6|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  52        |
      Inflammation, Chronic Active         |                                                                          |      2  1.5|
      Acinus, Atrophy                      |       1                                                                  |      4  1.5|
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  52        |
      Inflammation                         |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  53        |
      Cyst, Squamous                       |                                                                          |      1  2.0|
      Erosion                              |                                                                          |      1  2.0|
      Hyperkeratosis                       |                                                                          |      1  1.0|
      Hyperplasia, Squamous                |                                                                          |      4  1.8|
      Inflammation                         |                                                                          |      2  1.5|
      Mineralization                       |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  53        |
      Diverticulum                         |                                                                          |      1     |
                                           |__________________________________________________________________________|____________|
   Tooth                                   |       +                                                                  |  12        |
      Peridontal Tissue, Inflammation      |       3                                                                  |     12  1.3|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  57                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 6| 6|                                                                 |            |
                             DAY ON TEST   | 3| 3| 5|                                                                 |            |
                                           | 6| 5| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 2| 2| 2|                                                                 |      A     |
    10 NG/KG                               | 9| 9| 9|                                                                 |      L     |
                                           | 0| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +                                                                  |  53        |
      Thrombosis                           |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  53        |
      Cardiomyopathy                       |       1                                                                  |     22  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |     18  1.6|
      Atrophy                              |                                                                          |      4  1.5|
      Degeneration, Cystic                 |                                                                          |     21  2.1|
      Hyperplasia                          |                                                                          |     18  2.4|
      Hypertrophy                          | 1  2  1                                                                  |     46  2.0|
      Necrosis                             |                                                                          |      2  1.5|
      Vacuolization Cytoplasmic            | 1  1                                                                     |     12  1.3|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |      2  2.0|
      Hyperplasia                          |    3  3                                                                  |     18  2.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  53        |
      Hyperplasia                          |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +                                                                  |  47        |
      Fibrosis                             |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  M                                                                  |  52        |
      Angiectasis                          |    3                                                                     |     25  2.3|
      Cytoplasmic Alteration               |                                                                          |      1  1.0|
      Vacuolization Cytoplasmic            |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia           |                                                                          |     16  2.3|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  58                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 6| 6|                                                                 |            |
                             DAY ON TEST   | 3| 3| 5|                                                                 |            |
                                           | 6| 5| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 2| 2| 2|                                                                 |      A     |
    10 NG/KG                               | 9| 9| 9|                                                                 |      L     |
                                           | 0| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Thyroid Gland                           | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Inflammation, Suppurative            | 2                                                                        |      1  2.0|
      C-Cell, Hyperplasia                  |       2                                                                  |     22  2.1|
      Follicular Cell, Hypertrophy         |                                                                          |      4  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +                                                                  |  53        |
      Hyperplasia, Basal Cell              |                                                                          |      1  2.0|
      Inflammation                         | 1  3  1                                                                  |     35  1.7|
      Duct, Cyst                           | 1  3  2                                                                  |     41  2.2|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  53        |
      Atrophy                              | 4  4  4                                                                  |     50  4.0|
      Cyst                                 |       2                                                                  |     13  2.4|
      Fibrosis                             |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |   2        |
      Inflammation                         |                                                                          |      1  2.0|
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +                                                                  |  53        |
      Inflammation, Chronic Active         |                                                                          |      3  2.7|
      Inflammation, Suppurative            |                                                                          |     12  2.4|
      Metaplasia, Squamous                 | 3                                                                        |     28  2.5|
      Ulcer                                |                                                                          |      1  2.0|
      Cervix, Hyperplasia, Stromal         |                                                                          |      1  4.0|
      Endometrium, Adenomyosis             |                                                                          |      1  3.0|
      Endometrium, Hyperplasia, Cystic     |    1  1                                                                  |     35  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  59                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 6| 6|                                                                 |            |
                             DAY ON TEST   | 3| 3| 5|                                                                 |            |
                                           | 6| 5| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 2| 2| 2|                                                                 |      A     |
    10 NG/KG                               | 9| 9| 9|                                                                 |      L     |
                                           | 0| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Serosa, Inflammation, Chronic Active |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
      Cyst                                 |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
      Hyperplasia                          | 2     4                                                                  |     32  3.2|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   3        |
      Lumbar, Ectasia                      |                                                                          |      1  3.0|
      Mediastinal, Hyperplasia, Histiocytic|                                                                          |      1  2.0|
      Mediastinal, Pigmentation            |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  52        |
      Hyperplasia, Lymphoid                | 2                                                                        |      3  2.0|
      Hyperplasia, Plasma Cell             |    2  3                                                                  |     23  2.4|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  53        |
      Hematopoietic Cell Proliferation     |       3                                                                  |     38  1.3|
      Necrosis                             |                                                                          |      1  3.0|
      Pigmentation                         | 1  3                                                                     |     49  1.5|
      Lymphoid Follicle, Atrophy           |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +                                                                  |  52        |
      Atrophy                              | 3  2  2                                                                  |     44  3.0|
      Hemorrhage                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  60                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 6| 6|                                                                 |            |
                             DAY ON TEST   | 3| 3| 5|                                                                 |            |
                                           | 6| 5| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 2| 2| 2|                                                                 |      A     |
    10 NG/KG                               | 9| 9| 9|                                                                 |      L     |
                                           | 0| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
      Hyperplasia                          |       2                                                                  |     24  1.5|
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +                                                                  |  53        |
      Hemorrhage                           | 3                                                                        |      1  3.0|
      Hyperplasia, Squamous                |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      2  3.0|
      Necrosis                             |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Hydrocephalus                        |    2                                                                     |      1  2.0|
      Mineralization                       |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic, Focal     |       1                                                                  |      1  1.0|
      Cerebellum, Necrosis                 |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Peripheral Nerve                        |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
      Gliosis                              |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  53        |
      Congestion                           |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  61                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 6| 6|                                                                 |            |
                             DAY ON TEST   | 3| 3| 5|                                                                 |            |
                                           | 6| 5| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 2| 2| 2|                                                                 |      A     |
    10 NG/KG                               | 9| 9| 9|                                                                 |      L     |
                                           | 0| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Edema                                |                                                                          |      2  2.0|
      Infiltration Cellular, Histiocyte    |    2  2                                                                  |     43  1.8|
      Inflammation, Granulomatous          |                                                                          |      2  2.5|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Bronchiolar                     |    2  1                                                                  |     33  1.5|
      Bronchiole, Dilatation               |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
      Turbinate, Septum, Inflammation      |                                                                          |      1  2.0|
      Turbinate, Respiratory Epithelium,   |                                                                          |            |
           Hyperplasia                     |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ear                                     |                                                                          |   2        |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +                                                                  |  53        |
      Cornea, Inflammation, Suppurative    |                                                                          |      1  1.0|
      Retina, Atrophy                      |                                                                          |      5  2.2|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  53        |
      Calculus Micro Observation Only      |                                                                          |      1     |
      Casts Protein                        |                                                                          |      2  1.0|
      Infarct                              |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      2  2.0|
      Mineralization                       |       1                                                                  |     30  1.0|
      Nephropathy                          |    1  1                                                                  |     32  1.3|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  62                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 6| 6|                                                                 |            |
                             DAY ON TEST   | 3| 3| 5|                                                                 |            |
                                           | 6| 5| 9|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 2| 2| 2|                                                                 |      A     |
    10 NG/KG                               | 9| 9| 9|                                                                 |      L     |
                                           | 0| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
      Papilla, Necrosis                    |                                                                          |      1  3.0|
      Pelvis, Dilatation                   |                                                                          |      1  3.0|
      Pelvis, Inflammation                 |                                                                          |      1  2.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      8  1.8|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |      4  1.5|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  63                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 4| 7| 4| 3| 5| 3| 7| 4| 6| 3| 4| 6| 6| 7| 6| 3| 6| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 1| 5| 3| 8| 3| 4| 8| 3| 1| 7| 7| 0| 2| 2| 3| 0| 8| 2| 3| 3| 3| 5| 3|             
                                           | 1| 1| 5| 3| 1| 5| 8| 5| 0| 2| 7| 5| 3| 6| 6| 6| 1| 7| 9| 6| 2| 2| 1| 7| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    22 NG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 9| 1| 2| 4| 6| 7| 8| 9| 0| 6| 9| 0| 1| 2| 3| 4| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Inflammation             |                                                                   2      |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |             X                                X  X                 X     X|             
      Basophilic Focus, Multiple           |                                                                          |             
      Cholangiofibrosis                    |                                                                          |             
      Clear Cell Focus                     |                                                                          |             
      Clear Cell Focus, Multiple           | X                                                                        |             
      Degeneration, Cystic                 |                                                                          |             
      Eosinophilic Focus                   |          X  X        X  X                          X        X            |             
      Eosinophilic Focus, Multiple         |       X        X                 X        X     X        X        X  X  X|             
      Fatty Change, Diffuse                | 2  1  2     1     2  1                    2        1           1         |             
      Fatty Change, Focal                  |                                                                   2      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Hyperplasia, Nodular                 |             X                                                            |             
      Inflammation                         | 2  2  1  2  2  1  2  1  1  1  1  1  1  1  1     1  3  1  2  1  3  2  1  1|             
      Mitotic Alteration                   |                                                                          |             
      Mixed Cell Focus, Multiple           | X  X        X  X           X     X              X  X     X  X     X      |             
      Necrosis                             |                      2        2     2     2                    2         |             
      Pigmentation                         | 2  2  1  1  2  1  1  2  1  2  1  2  1  1  2  1  2  2  2  2     2  2  1  2|             
      Toxic Hepatopathy                    | 1  1  1        1           1              2     1  1     1     2        1|             
      Bile Duct, Cyst                      |                                                                1     2   |             
      Bile Duct, Fibrosis                  |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  64                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 4| 7| 4| 3| 5| 3| 7| 4| 6| 3| 4| 6| 6| 7| 6| 3| 6| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 1| 5| 3| 8| 3| 4| 8| 3| 1| 7| 7| 0| 2| 2| 3| 0| 8| 2| 3| 3| 3| 5| 3|             
                                           | 1| 1| 5| 3| 1| 5| 8| 5| 0| 2| 7| 5| 3| 6| 6| 6| 1| 7| 9| 6| 2| 2| 1| 7| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    22 NG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 9| 1| 2| 4| 6| 7| 8| 9| 0| 6| 9| 0| 1| 2| 3| 4| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Bile Duct, Hyperplasia               |                1           1           2  1     1        1  1  1        1|             
      Centrilobular, Degeneration          |                                                                2         |             
      Hepatocyte, Hypertrophy              | 1  1  2     1  3  1     1  1  1  1  1  1  1  3  2  3  1  2  1  3     1  2|             
      Hepatocyte, Multinucleated           |    1  1     1  1           1     1  1     2        1     1        1     1|             
      Oval Cell, Hyperplasia               |             1           1  1              2              1  1  1        1|             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |       +              +           +     +     +           +     +         |             
      Gingival, Hyperplasia, Squamous      |       2              3                       1           1     1         |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                                    1                     |             
      Necrosis                             |                                                                          |             
      Acinus, Atrophy                      |                                                    2              1      |             
      Acinus, Hyperplasia                  |                            2                                             |             
      Acinus, Vacuolization Cytoplasmic    |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                                   2      |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +|             
      Atrophy                              |                                              3                 2         |             
      Inflammation                         |                                              2                 2         |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Hyperkeratosis                       |                3                                                         |             
      Hyperplasia, Squamous                |                2                                                         |             
      Ulcer                                |                1                                                         |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                  2                                       |             
                                           |__________________________________________________________________________|             
   Tooth                                   |                   +  +                                +           +      |             
      Peridontal Tissue, Inflammation      |                   2  3                                1           1      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  65                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 4| 7| 4| 3| 5| 3| 7| 4| 6| 3| 4| 6| 6| 7| 6| 3| 6| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 1| 5| 3| 8| 3| 4| 8| 3| 1| 7| 7| 0| 2| 2| 3| 0| 8| 2| 3| 3| 3| 5| 3|             
                                           | 1| 1| 5| 3| 1| 5| 8| 5| 0| 2| 7| 5| 3| 6| 6| 6| 1| 7| 9| 6| 2| 2| 1| 7| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    22 NG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 9| 1| 2| 4| 6| 7| 8| 9| 0| 6| 9| 0| 1| 2| 3| 4| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1        1           1  1     1           1     1     1  1  2     1  2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    2        2              2     2              2        1        2     2|             
      Atrophy                              |                                           3                 4            |             
      Degeneration, Cystic                 | 2     3                    2     2           1  1           4        2  2|             
      Hyperplasia                          |       3  1  1  2     2     3  2  2           2  3  3              2     2|             
      Hypertrophy                          | 2  2     1  2     1     1  2     4  1  1     2  3     1  2  2  2  2  3  4|             
      Necrosis                             |                                                          3               |             
      Thrombosis                           |                                                                2         |             
      Vacuolization Cytoplasmic            |    1        2     2              2        3  1  1              1         |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia                          |                                        2           2     1        2      |             
      Inflammation, Suppurative            |                                              2                           |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  M  +  +  +  +  M  +  M  M  +  +  M  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          2           2     2              2     2        3     2  2     2|             
      Cytoplasmic Alteration               |                2                                                         |             
      Vacuolization Cytoplasmic            |                                                                          |             
      Pars Distalis, Hyperplasia           |    1  2  3                                   2     3        2  3  2  3   |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |                                           2                              |             
      C-Cell, Hyperplasia                  |             2           2        1              2  3     2     2        3|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  66                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 4| 7| 4| 3| 5| 3| 7| 4| 6| 3| 4| 6| 6| 7| 6| 3| 6| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 1| 5| 3| 8| 3| 4| 8| 3| 1| 7| 7| 0| 2| 2| 3| 0| 8| 2| 3| 3| 3| 5| 3|             
                                           | 1| 1| 5| 3| 1| 5| 8| 5| 0| 2| 7| 5| 3| 6| 6| 6| 1| 7| 9| 6| 2| 2| 1| 7| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    22 NG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 9| 1| 2| 4| 6| 7| 8| 9| 0| 6| 9| 0| 1| 2| 3| 4| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Follicular Cell, Hypertrophy         | 1     2                    1                       1                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1  3  1     2  1     1        1  1  1  2     1  2     1     1     1  2  1|             
      Duct, Cyst                           | 1  3  1  1  2     1     2  1  1  3     2  3     1  2  2  1     2  2  2  3|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    4  4     4  3  4  4  4  4  4  4     4  4  4  4  4  4     4     4  4  4|             
      Congestion                           |                                                                          |             
      Cyst                                 |    2     3     2                       2  2     2  2     2     2     3  2|             
      Inflammation, Chronic Active         |                                                    3                     |             
      Inflammation, Suppurative            |                                                                   4      |             
      Periovarian Tissue, Inflammation,    |                                                                          |             
           Suppurative                     |                                                       2                  |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |             3        3                                                   |             
      Metaplasia, Squamous                 |          3     2        2  2  1  1     3        2  2        3     4  3   |             
      Necrosis                             |                                                                          |             
      Cervix, Hyperplasia, Stromal         |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |    3  1     2  1        1  2              3     2     4  1  3        3  3|             
      Epithelium, Hyperplasia              |             3                                                            |             
                                           |__________________________________________________________________________|             
   Vagina                                  |          +                                                               |             
      Inflammation                         |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       3  4  3  3  3  3        3  3  3  3  3  4     3  3  4  3        3   |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                              +                           |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  67                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 4| 7| 4| 3| 5| 3| 7| 4| 6| 3| 4| 6| 6| 7| 6| 3| 6| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 1| 5| 3| 8| 3| 4| 8| 3| 1| 7| 7| 0| 2| 2| 3| 0| 8| 2| 3| 3| 3| 5| 3|             
                                           | 1| 1| 5| 3| 1| 5| 8| 5| 0| 2| 7| 5| 3| 6| 6| 6| 1| 7| 9| 6| 2| 2| 1| 7| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    22 NG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 9| 1| 2| 4| 6| 7| 8| 9| 0| 6| 9| 0| 1| 2| 3| 4| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Deep Cervical, Hemorrhage            |                                              3                           |             
      Lumbar, Ectasia                      |                                                                          |             
      Lumbar, Hemorrhage                   |                                                                          |             
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |             
      Lumbar, Pigmentation                 |                                                                          |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +|             
      Hyperplasia, Plasma Cell             | 2        2                 2           2  2  3  2                 2      |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 1  1  1  3  1  3  2        1  1  2  1     1  2  1  1     3  1  3  1  2  1|             
      Pigmentation                         | 2  2  1  1  2  1  2  2  2  2  1  1  1  1  2  1  2  1  2  1     1  2  1  2|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Atrophy                              | 3  2  3     4  2  3  4     2  2  3     2  3  3  4  4  2  2  4  3  4  4   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                3                                                         |             
      Hyperplasia                          | 1           1                             2  1  1        1  2  1        1|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  68                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 4| 7| 4| 3| 5| 3| 7| 4| 6| 3| 4| 6| 6| 7| 6| 3| 6| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 1| 5| 3| 8| 3| 4| 8| 3| 1| 7| 7| 0| 2| 2| 3| 0| 8| 2| 3| 3| 3| 5| 3|             
                                           | 1| 1| 5| 3| 1| 5| 8| 5| 0| 2| 7| 5| 3| 6| 6| 6| 1| 7| 9| 6| 2| 2| 1| 7| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    22 NG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 9| 1| 2| 4| 6| 7| 8| 9| 0| 6| 9| 0| 1| 2| 3| 4| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Histiocyte    | 2  2  2  2  1        2  1  2     2        2  1  1  2     1  3  1  1  2  1|             
      Inflammation, Granulomatous          |                1                                   1                     |             
      Inflammation, Suppurative            |                                     1                                    |             
      Necrosis                             |                                                                          |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     | 2  2  1  1  1        1  1  2     1        2     1  2     1  2  1     1  1|             
      Serosa, Inflammation, Focal,         |                                                                          |             
          Suppurative                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                     2                                    |             
      Nasopharyngeal Duct, Inflammation    |                                                                          |             
      Nasopharyngeal Duct, Necrosis        |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |                                     3                                    |             
      Turbinate, Septum, Inflammation      |    2                                                                     |             
      Turbinate, Respiratory Epithelium,   |                                                                          |             
           Hyperplasia                     |                                                 3                        |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Retina, Atrophy                      |                                                    2           2         |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |       X                                                                  |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  69                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 4| 7| 4| 3| 5| 3| 7| 4| 6| 3| 4| 6| 6| 7| 6| 3| 6| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 3| 3| 1| 5| 3| 8| 3| 4| 8| 3| 1| 7| 7| 0| 2| 2| 3| 0| 8| 2| 3| 3| 3| 5| 3|             
                                           | 1| 1| 5| 3| 1| 5| 8| 5| 0| 2| 7| 5| 3| 6| 6| 6| 1| 7| 9| 6| 2| 2| 1| 7| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    22 NG/KG                               | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 6| 7| 9| 1| 2| 4| 6| 7| 8| 9| 0| 6| 9| 0| 1| 2| 3| 4| 5| 6|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
      Inflammation, Chronic Active         |       2                                                                  |             
      Inflammation, Suppurative            |                                                                3         |             
      Mineralization                       | 1     1  1     1  1     1  1  1           1           1     1  1  1  1  1|             
      Necrosis                             |                                                                3         |             
      Nephropathy                          | 2  1        1  1  2     1  1     1  2     1     2  1     1  1  2  2     2|             
      Pelvis, Inflammation                 |                                                                1         |             
      Transitional Epithelium, Hyperplasia |          1                 1                    1              2  2      |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  70                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 4| 0| 5| 7| 7| 6| 6| 7| 7| 1| 5| 4| 7| 5| 7| 6| 5| 6| 7| 7| 5| 5| 7| 7| 7|             
                             DAY ON TEST   | 1| 5| 9| 3| 3| 8| 9| 3| 0| 9| 7| 6| 0| 7| 3| 4| 7| 0| 3| 3| 6| 2| 3| 3| 3|             
                                           | 6| 3| 2| 1| 1| 0| 0| 2| 8| 7| 8| 2| 8| 8| 3| 5| 8| 1| 1| 2| 1| 2| 2| 1| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    22 NG/KG                               | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 9| 9| 9|             
                                           | 7| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 0| 1| 2| 3| 4| 2| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Muscularis, Inflammation             |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |       X                                                  X               |             
      Basophilic Focus, Multiple           |                   X                                                      |             
      Cholangiofibrosis                    |                                                          1               |             
      Clear Cell Focus                     |                                           X              X               |             
      Clear Cell Focus, Multiple           |                                                                         X|             
      Degeneration, Cystic                 |                                                          1              1|             
      Eosinophilic Focus                   |                      X                          X  X                     |             
      Eosinophilic Focus, Multiple         | X        X  X           X           X  X                          X      |             
      Fatty Change, Diffuse                |       1              1              2  1           1     1        1  1   |             
      Fatty Change, Focal                  |             1                                2                          2|             
      Hematopoietic Cell Proliferation     |       2                                            2                     |             
      Hepatodiaphragmatic Nodule           |                                                                      X   |             
      Hyperplasia, Nodular                 |          X                                               X               |             
      Inflammation                         | 1  1  2  1  1  1     1  1  1  1  1  2  1  2  2  1  2  1  1  1  2  1  1  2|             
      Mitotic Alteration                   |                                                 2                        |             
      Mixed Cell Focus, Multiple           |          X           X                 X  X  X        X  X        X  X  X|             
      Necrosis                             |                                  3                 3           2         |             
      Pigmentation                         |       3  2  1  2  3  2  1  1  2  2  3  2  2  1  1     1  2  2     2  2  2|             
      Toxic Hepatopathy                    |       2  2  1  1  3     1        1  2  1  1  1  1  1  1  1        1     1|             
      Bile Duct, Cyst                      |                                                                          |             
      Bile Duct, Fibrosis                  |                                        2                                 |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  71                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 4| 0| 5| 7| 7| 6| 6| 7| 7| 1| 5| 4| 7| 5| 7| 6| 5| 6| 7| 7| 5| 5| 7| 7| 7|             
                             DAY ON TEST   | 1| 5| 9| 3| 3| 8| 9| 3| 0| 9| 7| 6| 0| 7| 3| 4| 7| 0| 3| 3| 6| 2| 3| 3| 3|             
                                           | 6| 3| 2| 1| 1| 0| 0| 2| 8| 7| 8| 2| 8| 8| 3| 5| 8| 1| 1| 2| 1| 2| 2| 1| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    22 NG/KG                               | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 9| 9| 9|             
                                           | 7| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 0| 1| 2| 3| 4| 2| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Bile Duct, Hyperplasia               |          1  1     3     1           2  2  2  1        1  2        1      |             
      Centrilobular, Degeneration          |       3        1  3                                                      |             
      Hepatocyte, Hypertrophy              |       3  1  2  1  3  1  2  1     1  2  1     1  2        1        1  1  1|             
      Hepatocyte, Multinucleated           |       1  2  1  1  2  2           1     1     1                 1  1     1|             
      Oval Cell, Hyperplasia               |          1  1  1  3                 2  1  1           1  2        1      |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                   +                                                      |             
      Fat, Necrosis                        |                   3                                                      |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |       +        +        +                 +     +  +  +                  |             
      Gingival, Hyperplasia, Squamous      |       1        2        1                 2     3  2                     |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                   4                                                      |             
      Inflammation, Chronic Active         |                                        1                                 |             
      Necrosis                             |                   3                                                      |             
      Acinus, Atrophy                      |                                        2                             1   |             
      Acinus, Hyperplasia                  |                                                                          |             
      Acinus, Vacuolization Cytoplasmic    |             1                                                            |             
      Artery, Inflammation, Chronic Active |          3                                                               |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Inflammation                         |          3                                                               |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Squamous                |                         2                                                |             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   |    +  +     +           +           +     +     +                    +   |             
      Peridontal Tissue, Inflammation      |    2  1     1           1           1     1     2                    1   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  72                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 4| 0| 5| 7| 7| 6| 6| 7| 7| 1| 5| 4| 7| 5| 7| 6| 5| 6| 7| 7| 5| 5| 7| 7| 7|             
                             DAY ON TEST   | 1| 5| 9| 3| 3| 8| 9| 3| 0| 9| 7| 6| 0| 7| 3| 4| 7| 0| 3| 3| 6| 2| 3| 3| 3|             
                                           | 6| 3| 2| 1| 1| 0| 0| 2| 8| 7| 8| 2| 8| 8| 3| 5| 8| 1| 1| 2| 1| 2| 2| 1| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    22 NG/KG                               | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 9| 9| 9|             
                                           | 7| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 0| 1| 2| 3| 4| 2| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Cardiomyopathy                       |       1  1  1  1  1           1     1        1           1     1        1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          2  3        2              1     2  1           1              2|             
      Atrophy                              |             3                                                     2      |             
      Degeneration, Cystic                 |             3  3     3        3  2                    3  2        1      |             
      Hyperplasia                          |          3              2     2     3  2  3  2        3  3              2|             
      Hypertrophy                          |       2  2  4  4     4        3  2  2  1  2  2  2  1     4     2  2  2  2|             
      Necrosis                             |                                                                          |             
      Thrombosis                           |                                                                          |             
      Vacuolization Cytoplasmic            |       1  1  3        2              1  1  2        1     2        2      |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                   2      |             
      Hyperplasia                          |                                           1                             2|             
      Inflammation, Suppurative            |                                                                          |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       3  2  3  1     1              3                 2  1        2     3|             
      Cytoplasmic Alteration               |          1                                                        2  1   |             
      Vacuolization Cytoplasmic            |                                     2        1                           |             
      Pars Distalis, Hyperplasia           |                2  2  2                    3  2  1     1  3  2        3   |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Angiectasis                          |                                                                      2   |             
      Cyst                                 |                                                                          |             
      C-Cell, Hyperplasia                  |       3     2     2                 2           1     3              3  2|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  73                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 4| 0| 5| 7| 7| 6| 6| 7| 7| 1| 5| 4| 7| 5| 7| 6| 5| 6| 7| 7| 5| 5| 7| 7| 7|             
                             DAY ON TEST   | 1| 5| 9| 3| 3| 8| 9| 3| 0| 9| 7| 6| 0| 7| 3| 4| 7| 0| 3| 3| 6| 2| 3| 3| 3|             
                                           | 6| 3| 2| 1| 1| 0| 0| 2| 8| 7| 8| 2| 8| 8| 3| 5| 8| 1| 1| 2| 1| 2| 2| 1| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    22 NG/KG                               | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 9| 9| 9|             
                                           | 7| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 0| 1| 2| 3| 4| 2| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Follicular Cell, Hypertrophy         |                                        1     1           1               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Inflammation                         |    1  3     1     3     2     3  2  2  2  2  1     1  1           1     2|             
      Duct, Cyst                           |    3     2  1  4  3  3  3     1  2  2     3  2     2  2  3  1     2  1  2|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4     4  4  4  4     4  4  4  4  4  4     4     4  4  4  4  4  4  4  4  4|             
      Congestion                           |             2                                                            |             
      Cyst                                 |          2           2                                   3        2      |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Periovarian Tissue, Inflammation,    |                                                                          |             
           Suppurative                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            | 1           1     4                       3  1  2                        |             
      Metaplasia, Squamous                 | 3     2                    2  4           2  3     1     4           3  4|             
      Necrosis                             |                   4                                                      |             
      Cervix, Hyperplasia, Stromal         |                                           4                              |             
      Endometrium, Hyperplasia, Cystic     |          3  2  2     4     2     1        3           2     4     1  3   |             
      Epithelium, Hyperplasia              |                                                                          |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                   +                       +                              |             
      Inflammation                         |                   4                       4                              |             
      Necrosis                             |                   4                                                      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 4  3  3     3  3        3  3  3  3     4  2  2  4  3        3  4         |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                   +     +              +     +                           |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  74                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 4| 0| 5| 7| 7| 6| 6| 7| 7| 1| 5| 4| 7| 5| 7| 6| 5| 6| 7| 7| 5| 5| 7| 7| 7|             
                             DAY ON TEST   | 1| 5| 9| 3| 3| 8| 9| 3| 0| 9| 7| 6| 0| 7| 3| 4| 7| 0| 3| 3| 6| 2| 3| 3| 3|             
                                           | 6| 3| 2| 1| 1| 0| 0| 2| 8| 7| 8| 2| 8| 8| 3| 5| 8| 1| 1| 2| 1| 2| 2| 1| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    22 NG/KG                               | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 9| 9| 9|             
                                           | 7| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 0| 1| 2| 3| 4| 2| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
      Deep Cervical, Hemorrhage            |                                                                          |             
      Lumbar, Ectasia                      |                                        2     2                           |             
      Lumbar, Hemorrhage                   |                                              2                           |             
      Lumbar, Hyperplasia, Plasma Cell     |                                        3                                 |             
      Lumbar, Pigmentation                 |                                              3                           |             
      Mediastinal, Hemorrhage              |                         2                                                |             
      Mediastinal, Hyperplasia, Plasma Cell|                   3                                                      |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hyperplasia, Plasma Cell             |          2  2  3  3     2              2  2  2  4     3        2     2   |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                       2                  |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |       3  1  2  2  3  1  1     2  2     1  1  1  2  3  1  1     3  1     1|             
      Pigmentation                         | 2  2  1  1  1  1  1  2  2  2  1  1  3  1  2  1  1  1  2  1  1     2  2  2|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +|             
      Atrophy                              |       4  4  4     4  4  3     4  2  4     2  3  4     4  2     4  2  2  2|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |    1        3  1     1  2              1     1        1  2        1     2|             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Skeletal Muscle                         |                                  +                 +                     |             
      Hemorrhage                           |                                                    3                     |             
      Inflammation, Chronic Active         |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  75                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 4| 0| 5| 7| 7| 6| 6| 7| 7| 1| 5| 4| 7| 5| 7| 6| 5| 6| 7| 7| 5| 5| 7| 7| 7|             
                             DAY ON TEST   | 1| 5| 9| 3| 3| 8| 9| 3| 0| 9| 7| 6| 0| 7| 3| 4| 7| 0| 3| 3| 6| 2| 3| 3| 3|             
                                           | 6| 3| 2| 1| 1| 0| 0| 2| 8| 7| 8| 2| 8| 8| 3| 5| 8| 1| 1| 2| 1| 2| 2| 1| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    22 NG/KG                               | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 9| 9| 9|             
                                           | 7| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 0| 1| 2| 3| 4| 2| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Infiltration Cellular, Histiocyte    |       3  2  1  1  1  2  2     2  1  1  2  2  1  3  2  2  2     2  1  2  1|             
      Inflammation, Granulomatous          |                                                                          |             
      Inflammation, Suppurative            |                   2                                                      |             
      Necrosis                             |                   2                                                      |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     |       2  1           1  2     1        2  2  1  2  1  1  2        1  3  1|             
      Serosa, Inflammation, Focal,         |                                                                          |             
          Suppurative                      |                   2                                                      |             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                      1                                                   |             
      Nasopharyngeal Duct, Inflammation    |                   3                                                      |             
      Nasopharyngeal Duct, Necrosis        |                   3                                                      |             
      Respiratory Epithelium, Hyperplasia  |                                                                          |             
      Turbinate, Septum, Inflammation      |                                                                          |             
      Turbinate, Respiratory Epithelium,   |                                                                          |             
           Hyperplasia                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Retina, Atrophy                      |             3                                                            |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Inflammation                         |                   1                                      1               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                           X        X                     |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  76                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 4| 0| 5| 7| 7| 6| 6| 7| 7| 1| 5| 4| 7| 5| 7| 6| 5| 6| 7| 7| 5| 5| 7| 7| 7|             
                             DAY ON TEST   | 1| 5| 9| 3| 3| 8| 9| 3| 0| 9| 7| 6| 0| 7| 3| 4| 7| 0| 3| 3| 6| 2| 3| 3| 3|             
                                           | 6| 3| 2| 1| 1| 0| 0| 2| 8| 7| 8| 2| 8| 8| 3| 5| 8| 1| 1| 2| 1| 2| 2| 1| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    22 NG/KG                               | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 9| 9| 9|             
                                           | 7| 9| 0| 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6| 0| 1| 2| 3| 4| 2| 4| 5|             
 __________________________________________|__________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |             1  1  1     1     1  1  1  1  1        1  1     1  1  1  1   |             
      Necrosis                             |                                                                          |             
      Nephropathy                          |       1  3  1  1  2  2  2  1        2     1        1  1  1        1  1  2|             
      Pelvis, Inflammation                 |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                           1              1              1|             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  77                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 6|                                                                 |            |
                             DAY ON TEST   | 3| 3| 4|                                                                 |            |
                                           | 1| 3| 1|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    22 NG/KG                               | 9| 9| 9|                                                                 |      L     |
                                           | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  52        |
      Muscularis, Inflammation             |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Basophilic Focus                     |                                                                          |      7     |
      Basophilic Focus, Multiple           |                                                                          |      1     |
      Cholangiofibrosis                    |                                                                          |      1  1.0|
      Clear Cell Focus                     |                                                                          |      2     |
      Clear Cell Focus, Multiple           |                                                                          |      2     |
      Degeneration, Cystic                 |                                                                          |      2  1.0|
      Eosinophilic Focus                   | X                                                                        |     10     |
      Eosinophilic Focus, Multiple         |    X                                                                     |     17     |
      Fatty Change, Diffuse                |                                                                          |     17  1.3|
      Fatty Change, Focal                  |                                                                          |      4  1.8|
      Hematopoietic Cell Proliferation     | 1  1                                                                     |      4  1.5|
      Hepatodiaphragmatic Nodule           |                                                                          |      1     |
      Hyperplasia, Nodular                 |                                                                          |      3     |
      Inflammation                         | 1     3                                                                  |     50  1.4|
      Mitotic Alteration                   |                                                                          |      1  2.0|
      Mixed Cell Focus, Multiple           | X  X                                                                     |     23     |
      Necrosis                             |                                                                          |      8  2.3|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  78                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 6|                                                                 |            |
                             DAY ON TEST   | 3| 3| 4|                                                                 |            |
                                           | 1| 3| 1|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    22 NG/KG                               | 9| 9| 9|                                                                 |      L     |
                                           | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Pigmentation                         | 2  1  3                                                                  |     48  1.7|
      Toxic Hepatopathy                    |    1  1                                                                  |     30  1.2|
      Bile Duct, Cyst                      |                                                                          |      2  1.5|
      Bile Duct, Fibrosis                  |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               |    1  1                                                                  |     22  1.3|
      Centrilobular, Degeneration          |                                                                          |      4  2.3|
      Hepatocyte, Hypertrophy              | 1  2  1                                                                  |     42  1.5|
      Hepatocyte, Multinucleated           | 1  1                                                                     |     26  1.2|
      Oval Cell, Hyperplasia               |    1  1                                                                  |     20  1.3|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Fat, Necrosis                        |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |    +  +                                                                  |  16        |
      Gingival, Hyperplasia, Squamous      |    1  1                                                                  |     13  1.6|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  53        |
      Inflammation, Acute                  |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |                                                                          |      2  1.0|
      Necrosis                             |                                                                          |      1  3.0|
      Acinus, Atrophy                      |                                                                          |      4  1.5|
      Acinus, Hyperplasia                  |                                                                          |      1  2.0|
      Acinus, Vacuolization Cytoplasmic    |                                                                          |      1  1.0|
      Artery, Inflammation, Chronic Active |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  50        |
      Atrophy                              |                                                                          |      2  2.5|
      Inflammation                         |                                                                          |      3  2.3|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  53        |
      Edema                                |       2                                                                  |      1  2.0|
      Hyperkeratosis                       |                                                                          |      1  3.0|
      Hyperplasia, Squamous                |                                                                          |      2  2.0|
      Ulcer                                |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  79                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 6|                                                                 |            |
                             DAY ON TEST   | 3| 3| 4|                                                                 |            |
                                           | 1| 3| 1|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    22 NG/KG                               | 9| 9| 9|                                                                 |      L     |
                                           | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  53        |
      Mineralization                       |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |       +                                                                  |  13        |
      Peridontal Tissue, Inflammation      |       1                                                                  |     13  1.4|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  52        |
      Cardiomyopathy                       | 1                                                                        |     25  1.1|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
      Angiectasis                          |       2                                                                  |     17  1.8|
      Atrophy                              |       1                                                                  |      5  2.6|
      Degeneration, Cystic                 | 2                                                                        |     18  2.3|
      Hyperplasia                          | 3  2                                                                     |     25  2.3|
      Hypertrophy                          | 3  2  3                                                                  |     40  2.2|
      Necrosis                             |                                                                          |      1  3.0|
      Thrombosis                           |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            | 1  1  2                                                                  |     21  1.6|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hyperplasia                          | 1                                                                        |      7  1.6|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  53        |
      Hyperplasia                          |    4                                                                     |      1  4.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  80                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 6|                                                                 |            |
                             DAY ON TEST   | 3| 3| 4|                                                                 |            |
                                           | 1| 3| 1|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    22 NG/KG                               | 9| 9| 9|                                                                 |      L     |
                                           | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Parathyroid Gland                       | +  +  +                                                                  |  44        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  53        |
      Angiectasis                          |       2                                                                  |     20  2.1|
      Cytoplasmic Alteration               |                                                                          |      4  1.5|
      Vacuolization Cytoplasmic            |                                                                          |      2  1.5|
      Pars Distalis, Hyperplasia           | 2  1                                                                     |     21  2.1|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  51        |
      Angiectasis                          |                                                                          |      1  2.0|
      Cyst                                 |                                                                          |      1  2.0|
      C-Cell, Hyperplasia                  | 3  3  3                                                                  |     19  2.3|
      Follicular Cell, Hypertrophy         |                                                                          |      7  1.1|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +                                                                  |  52        |
      Inflammation                         | 1  2                                                                     |     34  1.6|
      Duct, Cyst                           | 2  1  1                                                                  |     42  2.0|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  53        |
      Atrophy                              | 4  4  4                                                                  |     44  4.0|
      Congestion                           |                                                                          |      1  2.0|
      Cyst                                 |                                                                          |     15  2.2|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Periovarian Tissue, Inflammation,    |                                                                          |            |
           Suppurative                     |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +                                                                  |  53        |
      Inflammation, Suppurative            |       1                                                                  |      9  2.1|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  81                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 6|                                                                 |            |
                             DAY ON TEST   | 3| 3| 4|                                                                 |            |
                                           | 1| 3| 1|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    22 NG/KG                               | 9| 9| 9|                                                                 |      L     |
                                           | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Metaplasia, Squamous                 |    2                                                                     |     23  2.5|
      Necrosis                             |                                                                          |      1  4.0|
      Cervix, Hyperplasia, Stromal         |                                                                          |      1  4.0|
      Endometrium, Hyperplasia, Cystic     | 3  2  3                                                                  |     27  2.4|
      Epithelium, Hyperplasia              |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   3        |
      Inflammation                         |                                                                          |      2  4.0|
      Necrosis                             |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
      Hyperplasia                          | 3  3                                                                     |     35  3.1|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   5        |
      Deep Cervical, Hemorrhage            |                                                                          |      1  3.0|
      Lumbar, Ectasia                      |                                                                          |      2  2.0|
      Lumbar, Hemorrhage                   |                                                                          |      1  2.0|
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |      1  3.0|
      Lumbar, Pigmentation                 |                                                                          |      1  3.0|
      Mediastinal, Hemorrhage              |                                                                          |      1  2.0|
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  50        |
      Hyperplasia, Plasma Cell             | 3  2                                                                     |     22  2.3|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  53        |
      Atrophy                              |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  53        |
      Hematopoietic Cell Proliferation     | 2  1                                                                     |     42  1.6|
      Pigmentation                         | 1  1  2                                                                  |     51  1.5|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  82                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 6|                                                                 |            |
                             DAY ON TEST   | 3| 3| 4|                                                                 |            |
                                           | 1| 3| 1|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    22 NG/KG                               | 9| 9| 9|                                                                 |      L     |
                                           | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
   Thymus                                  | +  +  +                                                                  |  49        |
      Atrophy                              | 2  4                                                                     |     41  3.1|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  53        |
      Cyst                                 |                                                                          |      1  3.0|
      Hyperplasia                          | 2  1                                                                     |     22  1.4|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  52        |
      Infiltration Cellular, Histiocyte    | 1  1  1                                                                  |     43  1.6|
      Inflammation, Granulomatous          |                                                                          |      2  1.0|
      Inflammation, Suppurative            |                                                                          |      2  1.5|
      Necrosis                             |                                                                          |      1  2.0|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Bronchiolar                     | 1  1  1                                                                  |     35  1.4|
      Serosa, Inflammation, Focal,         |                                                                          |            |
          Suppurative                      |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  83                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 6|                                                                 |            |
                             DAY ON TEST   | 3| 3| 4|                                                                 |            |
                                           | 1| 3| 1|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 3| 3| 3|                                                                 |      A     |
    22 NG/KG                               | 9| 9| 9|                                                                 |      L     |
                                           | 6| 7| 8|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
      Inflammation                         |    2                                                                     |      3  1.7|
      Nasopharyngeal Duct, Inflammation    |                                                                          |      1  3.0|
      Nasopharyngeal Duct, Necrosis        |                                                                          |      1  3.0|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      1  3.0|
      Turbinate, Septum, Inflammation      |                                                                          |      1  2.0|
      Turbinate, Respiratory Epithelium,   |                                                                          |            |
           Hyperplasia                     |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  52        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +                                                                  |  52        |
      Retina, Atrophy                      |                                                                          |      3  2.3|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +                                                                  |  52        |
      Inflammation                         |                                                                          |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  53        |
      Calculus Micro Observation Only      |                                                                          |      3     |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Mineralization                       | 1  1                                                                     |     32  1.0|
      Necrosis                             |                                                                          |      1  3.0|
      Nephropathy                          | 2  1  1                                                                  |     36  1.4|
      Pelvis, Inflammation                 |                                                                          |      1  1.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      8  1.3|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  52        |
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                             Page  84                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 6| 5| 6| 3| 7| 7| 4| 5| 5| 7| 1| 7| 6| 7| 1| 6| 3| 7| 7| 7|             
                             DAY ON TEST   | 3| 0| 3| 3| 7| 5| 1| 7| 4| 3| 3| 7| 8| 9| 0| 4| 3| 9| 3| 8| 5| 1| 3| 3| 3|             
                                           | 3| 8| 1| 1| 3| 9| 8| 2| 1| 1| 1| 4| 9| 0| 1| 1| 3| 4| 1| 5| 7| 7| 3| 2| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    46 NG/KG                               | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 4| 4| 4| 4| 4| 5|             
                                           | 1| 2| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 0| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Inflammation             |                         1                                            2   |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                                                                          |             
      Basophilic Focus, Multiple           |                      X                                                   |             
      Cholangiofibrosis                    |       2  2                          2  1  3           4                  |             
      Clear Cell Focus                     |                                                                          |             
      Clear Cell Focus, Multiple           |                                                                          |             
      Eosinophilic Focus                   |             X                                                            |             
      Eosinophilic Focus, Multiple         |          X              X        X     X  X     X  X                 X  X|             
      Fatty Change, Diffuse                | 1     1     1  1  1  2     3  1  1                    1  3        1     2|             
      Fatty Change, Focal                  |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                    2                     |             
      Hemorrhage                           |                                                                3         |             
      Hepatodiaphragmatic Nodule           |          X                                                              X|             
      Hyperplasia, Nodular                 |             X              X              X     X                        |             
      Inflammation                         | 1  1  1  1  1  1     1  2  2  1  1  1  1  1  2  1  1  2  2  1  1  1  1  1|             
      Mitotic Alteration                   |                         2                                                |             
      Mixed Cell Focus                     |                                                                          |             
      Mixed Cell Focus, Multiple           | X     X  X  X        X     X  X  X        X           X           X  X  X|             
      Necrosis                             |    2                    1                 1     2        2     3         |             
      Pigmentation                         | 2  3  2  2  2  2  2  2  2  2  2  1  2  3  2     2  2  2  2  2  1  1  2  2|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  85                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 6| 5| 6| 3| 7| 7| 4| 5| 5| 7| 1| 7| 6| 7| 1| 6| 3| 7| 7| 7|             
                             DAY ON TEST   | 3| 0| 3| 3| 7| 5| 1| 7| 4| 3| 3| 7| 8| 9| 0| 4| 3| 9| 3| 8| 5| 1| 3| 3| 3|             
                                           | 3| 8| 1| 1| 3| 9| 8| 2| 1| 1| 1| 4| 9| 0| 1| 1| 3| 4| 1| 5| 7| 7| 3| 2| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    46 NG/KG                               | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 4| 4| 4| 4| 4| 5|             
                                           | 1| 2| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 0| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Toxic Hepatopathy                    | 3  3  3  2  3     2  2     2  2  1  1  2  3     1  2  2  1  1     2  2  2|             
      Bile Duct, Fibrosis                  |                            1           2                                 |             
      Bile Duct, Hyperplasia               | 2  1  2  1  2     1  2     2  2     1  2  2        1  1     1  1  1  1  2|             
      Centrilobular, Degeneration          |                   2                                                      |             
      Hepatocyte, Hypertrophy              | 1  2  2     2     3     1  1  1  1     3  1  1  3  4  1  3     1         |             
      Hepatocyte, Multinucleated           | 2  2  1     1  1  2  1        2     1  3  1        2  1     2  1  1  1   |             
      Hepatocyte, Centrilobular, Atrophy   |                                                             2            |             
      Oval Cell, Hyperplasia               | 2  1  2  1  1     1        3  2        2  3     1  1  1     1     2  1  2|             
      Portal, Fibrosis                     |       2                                   1                 2            |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                            +        +                                    |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Fat, Necrosis                        |                            3                                             |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +           +           +     +                    +     +  +         |             
      Gingival, Hyperplasia, Squamous      | 3                          2     2                    2     2  1         |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Acinus, Atrophy                      |                   1                                                      |             
      Acinus, Hyperplasia                  |                                                       2           3      |             
      Acinus, Vacuolization Cytoplasmic    | 1     1     1  2           2  1                                   1  1   |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                   2      |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                2                                                         |             
      Hyperkeratosis                       |    2           2                                                         |             
      Hyperplasia, Squamous                |    3           3                                   3                     |             
      Inflammation                         |                                                                          |             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia                           |          2                                                               |             
      Mineralization                       |             2                       2        1                           |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  86                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 6| 5| 6| 3| 7| 7| 4| 5| 5| 7| 1| 7| 6| 7| 1| 6| 3| 7| 7| 7|             
                             DAY ON TEST   | 3| 0| 3| 3| 7| 5| 1| 7| 4| 3| 3| 7| 8| 9| 0| 4| 3| 9| 3| 8| 5| 1| 3| 3| 3|             
                                           | 3| 8| 1| 1| 3| 9| 8| 2| 1| 1| 1| 4| 9| 0| 1| 1| 3| 4| 1| 5| 7| 7| 3| 2| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    46 NG/KG                               | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 4| 4| 4| 4| 4| 5|             
                                           | 1| 2| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 0| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
   Tooth                                   |    +           +           +     +  +                 +        +         |             
      Peridontal Tissue, Inflammation      |    3           3           1     2  4                 1        1         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |                                     2                                    |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1  1  1  1        1  1     1     2           1  1  1     1     1  1  1|             
      Mineralization                       |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       2  2  2                 2           2           1           2  2  2|             
      Atrophy                              |                                        3        1                        |             
      Degeneration, Cystic                 | 2           2              2  2                    2              2      |             
      Hyperplasia                          | 3     3              2     3  3  2     2  3        2  2     2     2  1   |             
      Hypertrophy                          | 3  2  1  3  3  1           2  2  2     2  2  1  1  3  3     1     4  2  2|             
      Necrosis                             |                                                             3            |             
      Vacuolization Cytoplasmic            |    1  2                       2     2              1  1  2               |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          2                 2                                      2      |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  M  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       1  2  2        2     1           2           2  2     3            |             
      Cytoplasmic Alteration               |                                                                          |             
      Vacuolization Cytoplasmic            |                                     2                                    |             
      Pars Distalis, Hyperplasia           | 3  3  4           1        2  3           3     2                 3     3|             
      Pars Intermedia, Hyperplasia         |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  87                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 6| 5| 6| 3| 7| 7| 4| 5| 5| 7| 1| 7| 6| 7| 1| 6| 3| 7| 7| 7|             
                             DAY ON TEST   | 3| 0| 3| 3| 7| 5| 1| 7| 4| 3| 3| 7| 8| 9| 0| 4| 3| 9| 3| 8| 5| 1| 3| 3| 3|             
                                           | 3| 8| 1| 1| 3| 9| 8| 2| 1| 1| 1| 4| 9| 0| 1| 1| 3| 4| 1| 5| 7| 7| 3| 2| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    46 NG/KG                               | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 4| 4| 4| 4| 4| 5|             
                                           | 1| 2| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 0| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Angiectasis                          |                               2                                          |             
      C-Cell, Hyperplasia                  |    2                    1              2        1     3                  |             
      Follicular Cell, Hypertrophy         |       1                                         1  1                 1  2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Inflammation                         |          2  1  1     3        3        2  2           2  1           4   |             
      Duct, Cyst                           | 3  3  3  4  1  3  3  3     2  3     3  2  3  1     2  2  1        1  3  3|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4     4  4  4  4  4  4  4  4  4  4  4  4     4  4  4     4  4  4  4  4|             
      Cyst                                 |          2  2  2                          2     2                 2     3|             
      Fibrosis                             |          2                                                               |             
      Inflammation, Suppurative            |                                                                         2|             
                                           |__________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
      Necrosis                             |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomyosis                          |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                1  3                 3     3  1  2              2         |             
      Metaplasia, Squamous                 | 2        4        1  3  2     2  2        4     4  3  1     3  2     3   |             
      Cervix, Hyperplasia, Stromal         |                                                                          |             
      Cervix, Inflammation, Suppurative    |                                                             3            |             
      Endometrium, Hyperplasia, Cystic     | 2  1  2     2  2        2  3  2  2           1        3     4  1  3  1  2|             
                                           |__________________________________________________________________________|             
   Vagina                                  |                +                                                         |             
      Cyst                                 |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 3  3  3  3  3           3        3  3  3  3  4  3  4     4  4     2  2  2|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  88                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 6| 5| 6| 3| 7| 7| 4| 5| 5| 7| 1| 7| 6| 7| 1| 6| 3| 7| 7| 7|             
                             DAY ON TEST   | 3| 0| 3| 3| 7| 5| 1| 7| 4| 3| 3| 7| 8| 9| 0| 4| 3| 9| 3| 8| 5| 1| 3| 3| 3|             
                                           | 3| 8| 1| 1| 3| 9| 8| 2| 1| 1| 1| 4| 9| 0| 1| 1| 3| 4| 1| 5| 7| 7| 3| 2| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    46 NG/KG                               | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 4| 4| 4| 4| 4| 5|             
                                           | 1| 2| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 0| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                   +                 +  +  +                              |             
      Inguinal, Ectasia                    |                                           2                              |             
      Mediastinal, Congestion              |                                                                          |             
      Mediastinal, Ectasia                 |                                        2                                 |             
      Mediastinal, Hyperplasia, Histiocytic|                                                                          |             
      Mediastinal, Hyperplasia             |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                        2                                 |             
      Hyperplasia, Plasma Cell             | 2     3  2  2  2     3                 2                             2  2|             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                     3                                    |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Hyperplasia, Plasma Cell             |                   3                                                      |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2     2  2  1     2     2  1  1  1  2  1  1  2  2  3  2  1  1     1  1  1|             
      Pigmentation                         | 2  3  1  1  2  2  1  2  1  2  2  1  2  1  1  1  1  1  2     1  2  2  2  2|             
      Lymphoid Follicle, Atrophy           |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4     4  4  4  3  4  4  2  2  4  3  3  3        4  4  4  4  4     4  4  4|             
      Cyst                                 |             3                                                            |             
      Inflammation, Chronic Active         |             3                                                            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |       2           2           1     1     1  1           1  1     1  1   |             
      Inflammation, Chronic Active         |                                                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                            2                                             |             
      Ulcer                                |                            2                                             |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  89                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 6| 5| 6| 3| 7| 7| 4| 5| 5| 7| 1| 7| 6| 7| 1| 6| 3| 7| 7| 7|             
                             DAY ON TEST   | 3| 0| 3| 3| 7| 5| 1| 7| 4| 3| 3| 7| 8| 9| 0| 4| 3| 9| 3| 8| 5| 1| 3| 3| 3|             
                                           | 3| 8| 1| 1| 3| 9| 8| 2| 1| 1| 1| 4| 9| 0| 1| 1| 3| 4| 1| 5| 7| 7| 3| 2| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    46 NG/KG                               | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 4| 4| 4| 4| 4| 5|             
                                           | 1| 2| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 0| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                     3                                    |             
      Mineralization                       |    1                                                                     |             
      Artery, Thrombosis                   |                                     3                                    |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                     2                                    |             
      Infiltration Cellular, Histiocyte    | 2  1  2  2  2  2  1  2  1  2  2  2     2  2  1  2  2  2     2     2  3  2|             
      Metaplasia, Squamous                 |                                                                          |             
      Mineralization                       |                                     1                                    |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     | 1     2  2  2  1  1  2  1  3  2  2     3  2     1  2  1     1     2  2  2|             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst, Squamous                       |                                                                          |             
      Inflammation                         |                2  3     2        2        1                              |             
      Goblet Cell, Septum, Hyperplasia     |                                                                          |             
      Nasolacrimal Duct, Respiratory       |                                                                          |             
          Epithelium, Hyperplasia          |                                                             2            |             
      Olfactory Epithelium, Degeneration   |                2                                                         |             
      Olfactory Epithelium, Inflammation   |                                     3                                    |             
      Respiratory Epithelium, Cyst         |                                  2                                       |             
      Respiratory Epithelium, Hyperplasia  |                2  2                                                      |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lens, Degeneration                   |                                                                          |             
      Retina, Atrophy                      |       2  3                                                               |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  90                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 6| 5| 6| 3| 7| 7| 4| 5| 5| 7| 1| 7| 6| 7| 1| 6| 3| 7| 7| 7|             
                             DAY ON TEST   | 3| 0| 3| 3| 7| 5| 1| 7| 4| 3| 3| 7| 8| 9| 0| 4| 3| 9| 3| 8| 5| 1| 3| 3| 3|             
                                           | 3| 8| 1| 1| 3| 9| 8| 2| 1| 1| 1| 4| 9| 0| 1| 1| 3| 4| 1| 5| 7| 7| 3| 2| 2|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    46 NG/KG                               | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 3| 4| 4| 4| 4| 4| 5|             
                                           | 1| 2| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 6| 7| 8| 0| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                            1              1           1        1         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                     X                                    |             
      Casts Protein                        |                                                                          |             
      Cyst                                 |                                     2                                    |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                                             3            |             
      Mineralization                       | 1  1     2  1  1  1  1  1  1     1  3  1        1        1  3     1  1  1|             
      Necrosis                             |                                                                          |             
      Nephropathy                          | 1     2  1  1  1  2  1  1  3  1  1     1  1  1     1  1  1     1  1  1  1|             
      Pelvis, Dilatation                   |                                                             3            |             
      Pelvis, Inflammation                 |             2                                         2                  |             
      Transitional Epithelium, Hyperplasia |          2  3                 2                       2  1               |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |          2                                   1        2  2  3           1|             
      Transitional Epithelium, Hyperplasia |          2                                            2  2  2            |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  91                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 7| 7| 7| 4| 4| 6| 6| 7| 6| 7| 6| 7| 6| 7| 5| 4| 6| 3| 7| 7| 7|             
                             DAY ON TEST   | 9| 7| 3| 3| 3| 3| 3| 4| 8| 2| 7| 3| 4| 3| 8| 3| 7| 2| 5| 8| 7| 9| 3| 3| 0|             
                                           | 9| 8| 1| 1| 1| 2| 3| 4| 6| 1| 3| 3| 5| 1| 3| 2| 5| 0| 7| 6| 7| 6| 3| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    46 NG/KG                               | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 4| 5| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 7| 8| 9| 1| 2| 3| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Inflammation             |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                      X                                                   |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       1        2                                                         |             
      Basophilic Focus                     |             X     X                                                      |             
      Basophilic Focus, Multiple           |                                                    X                     |             
      Cholangiofibrosis                    |          4     1              2                    4              2      |             
      Clear Cell Focus                     |                                  X                                       |             
      Clear Cell Focus, Multiple           |                                                                          |             
      Eosinophilic Focus                   |                      X        X                    X                     |             
      Eosinophilic Focus, Multiple         |       X  X  X  X  X     X           X  X        X        X  X           X|             
      Fatty Change, Diffuse                |          1  1  1  1        2     1  1  1  1  1     1     1        1  1  1|             
      Fatty Change, Focal                  |                         1                                                |             
      Hematopoietic Cell Proliferation     |                                                             2            |             
      Hemorrhage                           |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Hyperplasia, Nodular                 |             X                                X                          X|             
      Inflammation                         | 1  1  1  1  1  1  1  1  1  1  1  1  1  2  1  2  2  1  1  1  2  1  1  1  1|             
      Mitotic Alteration                   |                                                                          |             
      Mixed Cell Focus                     |             X                                                  X         |             
      Mixed Cell Focus, Multiple           |       X  X     X  X  X  X        X  X  X                 X        X  X  X|             
      Necrosis                             |                               2                    3        2        1   |             
      Pigmentation                         | 2  2  2  2  2  2  2  2  1  2  3  2  2  2  3  2  2  3  3  2  2  1  2  2  1|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  92                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 7| 7| 7| 4| 4| 6| 6| 7| 6| 7| 6| 7| 6| 7| 5| 4| 6| 3| 7| 7| 7|             
                             DAY ON TEST   | 9| 7| 3| 3| 3| 3| 3| 4| 8| 2| 7| 3| 4| 3| 8| 3| 7| 2| 5| 8| 7| 9| 3| 3| 0|             
                                           | 9| 8| 1| 1| 1| 2| 3| 4| 6| 1| 3| 3| 5| 1| 3| 2| 5| 0| 7| 6| 7| 6| 3| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    46 NG/KG                               | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 4| 5| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 7| 8| 9| 1| 2| 3| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Toxic Hepatopathy                    |    2  2  2  2  2  1  2  1  1     2  1  1  1  3     3  2  1  2     1  1  1|             
      Bile Duct, Fibrosis                  |                                                          1               |             
      Bile Duct, Hyperplasia               |    2  1  1  1  2  1  1     2  1  1     2  1  2  1  2  1     1     1  1   |             
      Centrilobular, Degeneration          |                                                       2     2            |             
      Hepatocyte, Hypertrophy              |    3  2  2  3  2  2  3  3        2  1  1  2  2  3  2  3  1  3     1  2  2|             
      Hepatocyte, Multinucleated           | 1     1  1  1  1  1  2           1  1  1     2     2  2  1        1     1|             
      Hepatocyte, Centrilobular, Atrophy   |                                                                          |             
      Oval Cell, Hyperplasia               |    2  2  2  1  2  1  1  1  1  1  1     1  1  2  1  2  1     2     1  1   |             
      Portal, Fibrosis                     |                                              1     3                     |             
                                           |__________________________________________________________________________|             
   Mesentery                               |       +                                                           +      |             
      Artery, Inflammation, Chronic Active |       2                                                           3      |             
      Fat, Necrosis                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +                 +           +        +  +        +  +  +  +     +  +  +|             
      Gingival, Hyperplasia, Squamous      | 3                 2           2           3                 2     4  1  2|             
                                           |__________________________________________________________________________|             
   Pancreas                                | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |    1                                         2                 1         |             
      Acinus, Atrophy                      |    2                                         2                           |             
      Acinus, Hyperplasia                  |                                                                          |             
      Acinus, Vacuolization Cytoplasmic    |          1  1                    1     1                 1  1     1      |             
      Artery, Inflammation, Chronic Active |                                        3                          3      |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Squamous                |          1              2                                2               |             
      Inflammation                         |                                                          1  2            |             
      Ulcer                                |                                                             2            |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia                           |                                                                          |             
      Mineralization                       |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  93                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 7| 7| 7| 4| 4| 6| 6| 7| 6| 7| 6| 7| 6| 7| 5| 4| 6| 3| 7| 7| 7|             
                             DAY ON TEST   | 9| 7| 3| 3| 3| 3| 3| 4| 8| 2| 7| 3| 4| 3| 8| 3| 7| 2| 5| 8| 7| 9| 3| 3| 0|             
                                           | 9| 8| 1| 1| 1| 2| 3| 4| 6| 1| 3| 3| 5| 1| 3| 2| 5| 0| 7| 6| 7| 6| 3| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    46 NG/KG                               | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 4| 5| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 7| 8| 9| 1| 2| 3| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
   Tooth                                   |                +  +        +                 +              +        +  +|             
      Peridontal Tissue, Inflammation      |                1  1        2                 1              1        1  1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Aorta, Mineralization                |                                                                          |             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1  1  1  1  1  1        2           1     1     1        2     1      |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 1        1     1                 1                       1  2            |             
      Atrophy                              |                                                                   1  1  1|             
      Degeneration, Cystic                 |          1  3           2           3              3  2  1        3     2|             
      Hyperplasia                          |       3     3     2  1  2     3           2  3     2  2  3  2     3  2   |             
      Hypertrophy                          | 2  1  2  2  2  2  2  2  3  2     1  2  3  3  1     3  2  2  2  1  2  2  3|             
      Necrosis                             |    2                       3                                             |             
      Vacuolization Cytoplasmic            |       2     3  1  2                       2  1  1  2  1     2        2   |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2  3  2                                      2  3                     |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  M  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    1  2  2     2                       2     2  1  1        1           2|             
      Cytoplasmic Alteration               |                2           2           2                                 |             
      Vacuolization Cytoplasmic            |                                              3                           |             
      Pars Distalis, Hyperplasia           |    2  4     2  2  3     2  2     2  1     3     1           2     3  3  2|             
      Pars Intermedia, Hyperplasia         |                                                       2                  |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  94                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 7| 7| 7| 4| 4| 6| 6| 7| 6| 7| 6| 7| 6| 7| 5| 4| 6| 3| 7| 7| 7|             
                             DAY ON TEST   | 9| 7| 3| 3| 3| 3| 3| 4| 8| 2| 7| 3| 4| 3| 8| 3| 7| 2| 5| 8| 7| 9| 3| 3| 0|             
                                           | 9| 8| 1| 1| 1| 2| 3| 4| 6| 1| 3| 3| 5| 1| 3| 2| 5| 0| 7| 6| 7| 6| 3| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    46 NG/KG                               | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 4| 5| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 7| 8| 9| 1| 2| 3| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Angiectasis                          |          2                                2  2                           |             
      C-Cell, Hyperplasia                  |    2  1        1  1     2           2     3     2                       1|             
      Follicular Cell, Hypertrophy         |       1        1     2  1           1                                    |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 3     2  2  2  1  2        1        2        2  1           1  1  1  1  1|             
      Duct, Cyst                           |    1  1  3  2  2  2     2  1     1     3  2  2  2  3  3  2  3     2  2  2|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4  4  4  3  4  4  4  4  4  3  4  4  4  4  4  4  4  4  4  4  4  4  4  4|             
      Cyst                                 |                   2                    4  2     2     2  2               |             
      Fibrosis                             |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                           |__________________________________________________________________________|             
   Oviduct                                 |                            +                                             |             
      Necrosis                             |                            4                                             |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenomyosis                          |                   2                                                      |             
      Inflammation, Chronic Active         |       3  4        3                                                      |             
      Inflammation, Suppurative            |    3                       3        1                                3   |             
      Metaplasia, Squamous                 |    4  3     2  4  3  2  2  2     3  1  3        4        2     3     2  2|             
      Cervix, Hyperplasia, Stromal         |                   4                                                      |             
      Cervix, Inflammation, Suppurative    |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |          2  2     2  1     2        2        1     2  1     3  3     2  1|             
                                           |__________________________________________________________________________|             
   Vagina                                  |                   +                                   +                  |             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2  3  3     3     3  3  3  3  4     2           4  3  4  3  3        2  2|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  95                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 7| 7| 7| 4| 4| 6| 6| 7| 6| 7| 6| 7| 6| 7| 5| 4| 6| 3| 7| 7| 7|             
                             DAY ON TEST   | 9| 7| 3| 3| 3| 3| 3| 4| 8| 2| 7| 3| 4| 3| 8| 3| 7| 2| 5| 8| 7| 9| 3| 3| 0|             
                                           | 9| 8| 1| 1| 1| 2| 3| 4| 6| 1| 3| 3| 5| 1| 3| 2| 5| 0| 7| 6| 7| 6| 3| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    46 NG/KG                               | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 4| 5| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 7| 8| 9| 1| 2| 3| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |    +                       +                                             |             
      Inguinal, Ectasia                    |                                                                          |             
      Mediastinal, Congestion              |                            2                                             |             
      Mediastinal, Ectasia                 |                                                                          |             
      Mediastinal, Hyperplasia, Histiocytic|                            2                                             |             
      Mediastinal, Hyperplasia             |    4                                                                     |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hyperplasia, Plasma Cell             |          3     2                    2           2  2                     |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Histiocytic             |                                                             3            |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                           |__________________________________________________________________________|             
   Spleen                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    1  1  1  1  2  2  1  1  1  2     1  1     2  3  1  3  1  3     1  1  1|             
      Pigmentation                         |    2  2  1  1  2     1  1  2  1  2  1  2  3  2     2  1  1  1  2  2  2  2|             
      Lymphoid Follicle, Atrophy           |                                           2                              |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  M  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4  4     3  3  4     2  4     2  3  4  4  4  4     4  4  4  2  4  4  4|             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                    2                     |             
      Hyperplasia                          |                1           1     1     1     1     1              2      |             
      Inflammation, Chronic Active         |                               3                                          |             
                                           |__________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                          |             
      Ulcer                                |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  96                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 7| 7| 7| 4| 4| 6| 6| 7| 6| 7| 6| 7| 6| 7| 5| 4| 6| 3| 7| 7| 7|             
                             DAY ON TEST   | 9| 7| 3| 3| 3| 3| 3| 4| 8| 2| 7| 3| 4| 3| 8| 3| 7| 2| 5| 8| 7| 9| 3| 3| 0|             
                                           | 9| 8| 1| 1| 1| 2| 3| 4| 6| 1| 3| 3| 5| 1| 3| 2| 5| 0| 7| 6| 7| 6| 3| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    46 NG/KG                               | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 4| 5| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 7| 8| 9| 1| 2| 3| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |             1                                                            |             
      Artery, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Infiltration Cellular, Histiocyte    |    2  1  2  2  2  2  1  2  2  2  2  2  2  2  2  1  2  1  1  1  1  2  1  1|             
      Metaplasia, Squamous                 |          1        1              4                 2              3      |             
      Mineralization                       |                                                                          |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     |    2  1  3  2  1  2  1  1     2  3  2  2  2  2  1  2  1  1  1     3  1  1|             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst, Squamous                       |                                     3                                    |             
      Inflammation                         |                                                                          |             
      Goblet Cell, Septum, Hyperplasia     |                                                             2            |             
      Nasolacrimal Duct, Respiratory       |                                                                          |             
          Epithelium, Hyperplasia          |                                                                          |             
      Olfactory Epithelium, Degeneration   |                                                                          |             
      Olfactory Epithelium, Inflammation   |                                                                          |             
      Respiratory Epithelium, Cyst         |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |                                                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lens, Degeneration                   |                   4                                                      |             
      Retina, Atrophy                      |                   2                                         2            |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page  97                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 7| 7| 7| 7| 4| 4| 6| 6| 7| 6| 7| 6| 7| 6| 7| 5| 4| 6| 3| 7| 7| 7|             
                             DAY ON TEST   | 9| 7| 3| 3| 3| 3| 3| 4| 8| 2| 7| 3| 4| 3| 8| 3| 7| 2| 5| 8| 7| 9| 3| 3| 0|             
                                           | 9| 8| 1| 1| 1| 2| 3| 4| 6| 1| 3| 3| 5| 1| 3| 2| 5| 0| 7| 6| 7| 6| 3| 1| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    46 NG/KG                               | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 4| 5| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 7| 8| 9| 1| 2| 3| 7| 8| 9|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
      Retina, Degeneration                 |                   3                                                      |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                        1     2     1     1               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                              2                           |             
      Casts Protein                        |                         1                                                |             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic Active         |                                                 2                        |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |    1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1        1  1  1  1  1   |             
      Necrosis                             |                                                       2                  |             
      Nephropathy                          | 1     1  2  1  1  2     1        2     2     2     2        3     2  1  1|             
      Pelvis, Dilatation                   | 3                                                                        |             
      Pelvis, Inflammation                 |                      3                                            2      |             
      Transitional Epithelium, Hyperplasia |                      3     1                          3     1     3  1   |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                      2                                            3      |             
      Transitional Epithelium, Hyperplasia |                                                       2           3      |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  98                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6|                                                                 |            |
                             DAY ON TEST   | 3| 3| 4|                                                                 |            |
                                           | 3| 3| 2|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    46 NG/KG                               | 9| 9| 9|                                                                 |      L     |
                                           | 0| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  53        |
      Muscularis, Inflammation             |                                                                          |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  53        |
      Parasite Metazoan                    |    X                                                                     |      2     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Angiectasis                          |    2                                                                     |      3  1.7|
      Basophilic Focus                     |       X                                                                  |      3     |
      Basophilic Focus, Multiple           |                                                                          |      2     |
      Cholangiofibrosis                    |                                                                          |     11  2.5|
      Clear Cell Focus                     |                                                                          |      1     |
      Clear Cell Focus, Multiple           |    X                                                                     |      1     |
      Eosinophilic Focus                   |    X                                                                     |      5     |
      Eosinophilic Focus, Multiple         |       X                                                                  |     22     |
      Fatty Change, Diffuse                | 1     1                                                                  |     30  1.2|
      Fatty Change, Focal                  |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      2     |
      Hyperplasia, Nodular                 |                                                                          |      7     |
      Inflammation                         | 1  1  1                                                                  |     52  1.2|
      Mitotic Alteration                   |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page  99                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6|                                                                 |            |
                             DAY ON TEST   | 3| 3| 4|                                                                 |            |
                                           | 3| 3| 2|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    46 NG/KG                               | 9| 9| 9|                                                                 |      L     |
                                           | 0| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Mixed Cell Focus                     |                                                                          |      2     |
      Mixed Cell Focus, Multiple           | X  X                                                                     |     28     |
      Necrosis                             |                                                                          |     10  1.9|
      Pigmentation                         | 2  2  2                                                                  |     52  2.0|
      Toxic Hepatopathy                    | 1  1  1                                                                  |     45  1.8|
      Bile Duct, Fibrosis                  |                                                                          |      3  1.3|
      Bile Duct, Hyperplasia               | 2  2                                                                     |     40  1.4|
      Centrilobular, Degeneration          |                                                                          |      3  2.0|
      Hepatocyte, Hypertrophy              | 1  2  3                                                                  |     41  2.0|
      Hepatocyte, Multinucleated           | 1  1  2                                                                  |     36  1.4|
      Hepatocyte, Centrilobular, Atrophy   |                                                                          |      1  2.0|
      Oval Cell, Hyperplasia               |    2                                                                     |     38  1.5|
      Portal, Fibrosis                     |                                                                          |      5  1.8|
                                           |__________________________________________________________________________|____________|
   Mesentery                               | +     +                                                                  |   6        |
      Artery, Inflammation, Chronic Active | 2     2                                                                  |      4  2.3|
      Fat, Necrosis                        |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |    +  +                                                                  |  22        |
      Gingival, Hyperplasia, Squamous      |       2                                                                  |     15  2.2|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  52        |
      Inflammation, Chronic Active         |                                                                          |      3  1.3|
      Acinus, Atrophy                      |    1                                                                     |      4  1.5|
      Acinus, Hyperplasia                  |                                                                          |      2  2.5|
      Acinus, Vacuolization Cytoplasmic    |                                                                          |     15  1.1|
      Artery, Inflammation, Chronic Active |                                                                          |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  51        |
      Atrophy                              |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  53        |
      Erosion                              |                                                                          |      1  2.0|
      Hyperkeratosis                       |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 100                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6|                                                                 |            |
                             DAY ON TEST   | 3| 3| 4|                                                                 |            |
                                           | 3| 3| 2|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    46 NG/KG                               | 9| 9| 9|                                                                 |      L     |
                                           | 0| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Hyperplasia, Squamous                | 1                                                                        |      7  2.1|
      Inflammation                         |                                                                          |      2  1.5|
      Ulcer                                |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  53        |
      Metaplasia                           |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      3  1.7|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                                                                          |  14        |
      Peridontal Tissue, Inflammation      |                                                                          |     14  1.6|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +                                                                  |  53        |
      Aorta, Mineralization                |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  53        |
      Cardiomyopathy                       | 1  1  1                                                                  |     32  1.1|
      Mineralization                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
      Angiectasis                          | 2  1                                                                     |     17  1.6|
      Atrophy                              |                                                                          |      5  1.4|
      Degeneration, Cystic                 |    3  3                                                                  |     17  2.2|
      Hyperplasia                          | 2     3                                                                  |     29  2.3|
      Hypertrophy                          | 2  4  3                                                                  |     45  2.1|
      Necrosis                             |                                                                          |      3  2.7|
      Vacuolization Cytoplasmic            |                                                                          |     18  1.7|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  53        |
      Hyperplasia                          | 3  3                                                                     |     10  2.4|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 101                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6|                                                                 |            |
                             DAY ON TEST   | 3| 3| 4|                                                                 |            |
                                           | 3| 3| 2|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    46 NG/KG                               | 9| 9| 9|                                                                 |      L     |
                                           | 0| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Islets, Pancreatic                      | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +                                                                  |  45        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  53        |
      Angiectasis                          | 3  3                                                                     |     21  1.9|
      Cytoplasmic Alteration               |                                                                          |      3  2.0|
      Vacuolization Cytoplasmic            |                                                                          |      2  2.5|
      Pars Distalis, Hyperplasia           | 2                                                                        |     26  2.4|
      Pars Intermedia, Hyperplasia         |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |      4  2.0|
      C-Cell, Hyperplasia                  | 3  3                                                                     |     16  1.9|
      Follicular Cell, Hypertrophy         |                                                                          |     10  1.2|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +                                                                  |  51        |
      Inflammation                         | 1  1  1                                                                  |     28  1.7|
      Duct, Cyst                           |       2                                                                  |     41  2.2|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  53        |
      Atrophy                              | 4  4  4                                                                  |     50  4.0|
      Cyst                                 |       2                                                                  |     14  2.2|
      Fibrosis                             |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |   1        |
      Necrosis                             |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 102                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6|                                                                 |            |
                             DAY ON TEST   | 3| 3| 4|                                                                 |            |
                                           | 3| 3| 2|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    46 NG/KG                               | 9| 9| 9|                                                                 |      L     |
                                           | 0| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
   Uterus                                  | +  +  +                                                                  |  53        |
      Adenomyosis                          |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      3  3.3|
      Inflammation, Suppurative            |                                                                          |     11  2.3|
      Metaplasia, Squamous                 |    1  2                                                                  |     32  2.5|
      Cervix, Hyperplasia, Stromal         |                                                                          |      1  4.0|
      Cervix, Inflammation, Suppurative    |                                                                          |      1  3.0|
      Endometrium, Hyperplasia, Cystic     |    3  3                                                                  |     31  2.0|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   3        |
      Cyst                                 |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
      Hyperplasia                          | 2     2                                                                  |     37  2.9|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   6        |
      Inguinal, Ectasia                    |                                                                          |      1  2.0|
      Mediastinal, Congestion              |                                                                          |      1  2.0|
      Mediastinal, Ectasia                 |                                                                          |      1  2.0|
      Mediastinal, Hyperplasia, Histiocytic|                                                                          |      1  2.0|
      Mediastinal, Hyperplasia             |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  51        |
      Ectasia                              |                                                                          |      1  2.0|
      Hyperplasia, Plasma Cell             |    3                                                                     |     15  2.3|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                                                                  |  53        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Histiocytic             |                                                                          |      1  3.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  52        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 103                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6|                                                                 |            |
                             DAY ON TEST   | 3| 3| 4|                                                                 |            |
                                           | 3| 3| 2|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    46 NG/KG                               | 9| 9| 9|                                                                 |      L     |
                                           | 0| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Hematopoietic Cell Proliferation     |    1  1                                                                  |     44  1.5|
      Pigmentation                         | 2  2  2                                                                  |     49  1.6|
      Lymphoid Follicle, Atrophy           |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  M  +                                                                  |  46        |
      Atrophy                              | 2     4                                                                  |     44  3.6|
      Cyst                                 |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  53        |
      Cyst                                 |                                                                          |      1  2.0|
      Hyperplasia                          |       2                                                                  |     18  1.2|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +                                                                  |  53        |
      Hyperplasia, Squamous                |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      2  1.0|
      Artery, Thrombosis                   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 104                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6|                                                                 |            |
                             DAY ON TEST   | 3| 3| 4|                                                                 |            |
                                           | 3| 3| 2|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    46 NG/KG                               | 9| 9| 9|                                                                 |      L     |
                                           | 0| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
      Edema                                |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    | 2  2  2                                                                  |     49  1.8|
      Metaplasia, Squamous                 |                                                                          |      5  2.2|
      Mineralization                       |                                                                          |      1  1.0|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Bronchiolar                     | 3  1  2                                                                  |     45  1.7|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
      Cyst, Squamous                       |                                                                          |      1  3.0|
      Inflammation                         |                                                                          |      5  2.0|
      Goblet Cell, Septum, Hyperplasia     |                                                                          |      1  2.0|
      Nasolacrimal Duct, Respiratory       |                                                                          |            |
          Epithelium, Hyperplasia          |                                                                          |      1  2.0|
      Olfactory Epithelium, Degeneration   |                                                                          |      1  2.0|
      Olfactory Epithelium, Inflammation   |                                                                          |      1  3.0|
      Respiratory Epithelium, Cyst         |       2                                                                  |      2  2.0|
      Respiratory Epithelium, Hyperplasia  |                                                                          |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +                                                                  |  53        |
      Lens, Degeneration                   |                                                                          |      1  4.0|
      Retina, Atrophy                      |                                                                          |      4  2.3|
      Retina, Degeneration                 |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |      8  1.1|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  53        |
      Calculus Micro Observation Only      |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 105                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6|                                                                 |            |
                             DAY ON TEST   | 3| 3| 4|                                                                 |            |
                                           | 3| 3| 2|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 4| 4| 4|                                                                 |      A     |
    46 NG/KG                               | 9| 9| 9|                                                                 |      L     |
                                           | 0| 6| 7|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
      Casts Protein                        |                                                                          |      1  1.0|
      Cyst                                 |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Mineralization                       | 1  1  1                                                                  |     42  1.1|
      Necrosis                             |                                                                          |      1  2.0|
      Nephropathy                          | 1  2  2                                                                  |     39  1.4|
      Pelvis, Dilatation                   |                                                                          |      2  3.0|
      Pelvis, Inflammation                 |                                                                          |      4  2.3|
      Transitional Epithelium, Hyperplasia |                                                                          |     11  2.0|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |      8  2.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      6  2.2|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 106                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 5| 6| 6| 7| 6| 7| 7| 6| 7| 7| 7| 4| 7| 6| 3| 7| 7| 6| 6| 6| 7| 6|             
                             DAY ON TEST   | 3| 4| 5| 8| 6| 1| 3| 1| 3| 3| 3| 2| 1| 3| 7| 0| 1| 9| 3| 3| 0| 9| 1| 3| 6|             
                                           | 2| 1| 2| 1| 8| 0| 1| 0| 3| 1| 8| 1| 6| 3| 4| 1| 2| 6| 1| 1| 4| 3| 4| 2| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    100                                    | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 8| 8| 8| 8| 8| 8| 8|             
    NG/KG                                  | 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 1| 3| 4| 5| 6| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                   2                                                      |             
      Basophilic Focus                     |                                                                      X   |             
      Basophilic Focus, Multiple           |                X                 X  X           X                        |             
      Cholangiofibrosis                    |    2  3  3  1     2     2     2  2     2                 2  2  2  1  2  3|             
      Clear Cell Focus                     |                                                                          |             
      Clear Cell Focus, Multiple           |                                                       X                  |             
      Congestion                           |                      2                             2                     |             
      Cytoplasmic Alteration               |                                                       2                  |             
      Degeneration, Cystic                 |                2                                                         |             
      Eosinophilic Focus                   |                                                                         X|             
      Eosinophilic Focus, Multiple         | X  X  X  X  X  X  X  X  X     X     X           X  X  X  X  X     X  X   |             
      Fatty Change, Diffuse                |    2  2  1  2  2  2  2  2  1  2  1  3  2  2  2     2  2  2     2  2  2  2|             
      Fatty Change, Focal                  |                                                             1            |             
      Hematopoietic Cell Proliferation     |                2                                                         |             
      Hyperplasia, Nodular                 | X  X  X     X  X  X     X  X  X  X     X  X  X     X        X  X  X     X|             
      Inflammation                         | 1  1  2  1  1  1  1  1  1     2  3  1  1  1  1  1  2  1  1  1  1  2  1  1|             
      Mixed Cell Focus                     |                                                                         X|             
      Mixed Cell Focus, Multiple           | X                 X     X              X           X  X  X        X  X   |             
      Necrosis                             |    2  3                       2  3        2  2                 3        2|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 107                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 5| 6| 6| 7| 6| 7| 7| 6| 7| 7| 7| 4| 7| 6| 3| 7| 7| 6| 6| 6| 7| 6|             
                             DAY ON TEST   | 3| 4| 5| 8| 6| 1| 3| 1| 3| 3| 3| 2| 1| 3| 7| 0| 1| 9| 3| 3| 0| 9| 1| 3| 6|             
                                           | 2| 1| 2| 1| 8| 0| 1| 0| 3| 1| 8| 1| 6| 3| 4| 1| 2| 6| 1| 1| 4| 3| 4| 2| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    100                                    | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 8| 8| 8| 8| 8| 8| 8|             
    NG/KG                                  | 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 1| 3| 4| 5| 6| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Pigmentation                         | 2  3  2  3  2  2  2  3  2  2  3  2  2  2  2  2  2  2  2  2  2  2  2  2  2|             
      Thrombosis                           |                                                                          |             
      Toxic Hepatopathy                    | 3  4  4  4  3  3  4  4  4  3  4  4  4  3  3  3  3  3  3  4  3  4  3  4  4|             
      Artery, Inflammation, Chronic Active |          2                                                               |             
      Bile Duct, Cyst                      |       3           4     2     2        3        2              4     3   |             
      Bile Duct, Fibrosis                  |                               1                                          |             
      Bile Duct, Hyperplasia               | 2  2  2  3  2  3  2  2  2  2  2  2  2  3  2  2  2  1  1  2  2  3  2  2  2|             
      Centrilobular, Degeneration          |    2                 2                                                  3|             
      Hepatocyte, Hypertrophy              | 2  3  3  4  3  4  3  3  3  3  4  3  3  3  3  3     4  3  3  4  3  3  3  3|             
      Hepatocyte, Multinucleated           | 1     1  2  2  2     1  2  2  3  2  2  1  3  1  1  1  1  2  2  1  2  2  2|             
      Oval Cell, Hyperplasia               | 2  2  2  2  2  3  3  3  3  2  3  2  2  2  3  2  1  1  2  3  2  3  3  2  3|             
      Portal, Fibrosis                     |                   2  2  2     3     2     2  2        1  2     3        2|             
                                           |__________________________________________________________________________|             
   Mesentery                               | +        +     +        +                                                |             
      Artery, Inflammation, Chronic Active | 2        2     3        2                                                |             
      Fat, Necrosis                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +  +  +     +     +     +  +     +     +           +     +           +|             
      Gingival, Hyperplasia, Squamous      |    3  2  4     2           1                          4                 3|             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                3                                                         |             
      Inflammation, Chronic Active         |          3                                                           2   |             
      Necrosis                             |                2                                                         |             
      Acinus, Atrophy                      |    2     2     2  2                                      1               |             
      Acinus, Vacuolization Cytoplasmic    | 2  1        1     2  3  3  2  2        3     1  1     2  3  2  2  2  3   |             
      Artery, Inflammation, Chronic Active |          3     2  3                    3                                 |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Hyperkeratosis                       |                                                          2               |             
      Hyperplasia, Squamous                |       2     1                 2                          3     2     2   |             
      Inflammation                         |                                                          3               |             
      Necrosis                             |                                                                          |             
      Ulcer                                |       3                                                  3     1         |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 108                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 5| 6| 6| 7| 6| 7| 7| 6| 7| 7| 7| 4| 7| 6| 3| 7| 7| 6| 6| 6| 7| 6|             
                             DAY ON TEST   | 3| 4| 5| 8| 6| 1| 3| 1| 3| 3| 3| 2| 1| 3| 7| 0| 1| 9| 3| 3| 0| 9| 1| 3| 6|             
                                           | 2| 1| 2| 1| 8| 0| 1| 0| 3| 1| 8| 1| 6| 3| 4| 1| 2| 6| 1| 1| 4| 3| 4| 2| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    100                                    | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 8| 8| 8| 8| 8| 8| 8|             
    NG/KG                                  | 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 1| 3| 4| 5| 6| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                             3  2         |             
                                           |__________________________________________________________________________|             
   Tooth                                   | +  +  +              +  +  +     +              +                    +  +|             
      Peridontal Tissue, Inflammation      | 2  2  2              2  1  1     1              1                    1  3|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |          1  1  2  3  1  1  1        2        1  1  1     2  1  2     1  2|             
      Artery, Inflammation                 |                            1                                             |             
      Artery, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                2           1           2     2     1                 2   |             
      Atrophy                              |             3     3  1     3     2  4  2     4     1  2     2        4  2|             
      Degeneration, Cystic                 |    2           2                             2           2  2        3  2|             
      Hyperplasia                          | 3  3  3  4              3     2  2     2        2  2  4  2     2  2     2|             
      Hypertrophy                          |    3  2     2  4  2  3  2  4        4  3     4  2  1  2  2  2  2  1  4  4|             
      Mineralization                       |                                                                          |             
      Necrosis                             |    3                                                                     |             
      Vacuolization Cytoplasmic            | 1        2           3  1  3     2  3        3                    2      |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 1  1  2  2  2                 1                                2         |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Angiectasis                          | 2     1                                                  2               |             
      Cyst                                 |             2                                                            |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 109                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 5| 6| 6| 7| 6| 7| 7| 6| 7| 7| 7| 4| 7| 6| 3| 7| 7| 6| 6| 6| 7| 6|             
                             DAY ON TEST   | 3| 4| 5| 8| 6| 1| 3| 1| 3| 3| 3| 2| 1| 3| 7| 0| 1| 9| 3| 3| 0| 9| 1| 3| 6|             
                                           | 2| 1| 2| 1| 8| 0| 1| 0| 3| 1| 8| 1| 6| 3| 4| 1| 2| 6| 1| 1| 4| 3| 4| 2| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    100                                    | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 8| 8| 8| 8| 8| 8| 8|             
    NG/KG                                  | 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 1| 3| 4| 5| 6| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Pars Distalis, Hyperplasia           | 2  3     1     1  3  1  1  1  1                 2        2        2     1|             
      Pars Intermedia, Hyperplasia         |                                                                          |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |                                                                          |             
      C-Cell, Hyperplasia                  |    2     1  2                 1        3     2     2  2  2  1  2  3      |             
      Follicular Cell, Hypertrophy         | 1                 1        1           1        2  2        2        1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 2        1     1     2              2     2     1        1     1        1|             
      Duct, Cyst                           | 3  2     2  2  2  2  2  2  2  3  3  3  1  3  2        3  3  2  3  2  2  1|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4  4  4        4  4  4  4  4     4  3        4           4  4         |             
      Cyst                                 | 2                                      3  2  2              2            |             
      Inflammation, Chronic Active         |                                     3                                    |             
      Artery, Inflammation, Chronic Active |                                                                          |             
                                           |__________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
      Inflammation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                         3|             
      Hemorrhage                           |    3                                                                     |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                                             1            |             
      Metaplasia, Squamous                 | 1  1  2           1     1              2        1                        |             
      Endometrium, Hyperplasia, Cystic     | 2                    1           1     2  1     1     3                  |             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                                             +            |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 110                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 5| 6| 6| 7| 6| 7| 7| 6| 7| 7| 7| 4| 7| 6| 3| 7| 7| 6| 6| 6| 7| 6|             
                             DAY ON TEST   | 3| 4| 5| 8| 6| 1| 3| 1| 3| 3| 3| 2| 1| 3| 7| 0| 1| 9| 3| 3| 0| 9| 1| 3| 6|             
                                           | 2| 1| 2| 1| 8| 0| 1| 0| 3| 1| 8| 1| 6| 3| 4| 1| 2| 6| 1| 1| 4| 3| 4| 2| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    100                                    | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 8| 8| 8| 8| 8| 8| 8|             
    NG/KG                                  | 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 1| 3| 4| 5| 6| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                              4                           |             
      Hyperplasia                          | 2  2  3  3  4  2  2     2  2     3  3  3  3  3  3  3     3  4  3     3  3|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                           +              +     +         |             
      Mediastinal, Ectasia                 |                                                                2         |             
      Mediastinal, Hemorrhage              |                                           3              2               |             
      Mediastinal, Hyperplasia, Histiocytic|                                                                          |             
      Mediastinal, Pigmentation            |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                            3                                         3   |             
      Hyperplasia, Lymphoid                |          2                                                        2      |             
      Hyperplasia, Plasma Cell             |                      2  3                 2  2     3     2           3   |             
      Inflammation, Suppurative            |                            2                                             |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Ectasia                              |                                                                          |             
      Hyperplasia, Histiocytic             |             3                                                            |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 2  2  2  1  2  2  1     1  1  1        1  3  2  2  2  1  1  2  1     1  1|             
      Hyperplasia, Lymphoid                |                   2                                                      |             
      Pigmentation                         | 1  1  1  1  1  2  2  2  1  1  2     2  3  1  1     1  1  1     1  2  2   |             
      Lymphoid Follicle, Atrophy           |                                                                         2|             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  M  +  +  +  +  +  +  +  +  +  +  M  M  +  M  +  +  +  +  +  +  M  M|             
      Atrophy                              | 4  4     4  4  4  3  4  4  4  4  4  4        4     4  4  4  4  4  4      |             
      Cyst                                 |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    2                                                                     |             
      Hyperplasia                          |                   1        2     1     1     1        2  2        2  2  1|             
      Inflammation, Granulomatous          |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 111                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 5| 6| 6| 7| 6| 7| 7| 6| 7| 7| 7| 4| 7| 6| 3| 7| 7| 6| 6| 6| 7| 6|             
                             DAY ON TEST   | 3| 4| 5| 8| 6| 1| 3| 1| 3| 3| 3| 2| 1| 3| 7| 0| 1| 9| 3| 3| 0| 9| 1| 3| 6|             
                                           | 2| 1| 2| 1| 8| 0| 1| 0| 3| 1| 8| 1| 6| 3| 4| 1| 2| 6| 1| 1| 4| 3| 4| 2| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    100                                    | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 8| 8| 8| 8| 8| 8| 8|             
    NG/KG                                  | 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 1| 3| 4| 5| 6| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |             3                                                            |             
      Inflammation, Chronic Active         |                                     3                                    |             
      Epidermis, Inflammation              |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fracture                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                      2   |             
      Glial Cell, Hyperplasia              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                           3  2                           |             
      Infiltration Cellular, Histiocyte    | 2  2  2  2  2  2  2  2  2  2  2     3  2  3  2  2  2  2  2  2  2  2  2  2|             
      Inflammation, Chronic Active         |                                           3                              |             
      Metaplasia, Squamous                 |    1              2                                      3  3           2|             
      Mineralization                       |                                                                          |             
      Necrosis                             |                                           4                              |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     | 2  2  1  1  1  2  3  2  3  2  2     2  1     2  3  1  2  2  2  3  2  2  2|             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Nasopharyngeal Duct, Inflammation    |                                                                          |             
      Olfactory Epithelium, Inflammation   |                                                                          |             
      Septum, Hyperplasia, Squamous        |                                                                          |             
      Septum, Inflammation                 |                                                                          |             
      Turbinate, Hyperplasia, Squamous     |                                                                          |             
      Turbinate, Septum, Inflammation      |                               3                                          |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 112                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 5| 6| 6| 7| 6| 7| 7| 6| 7| 7| 7| 4| 7| 6| 3| 7| 7| 6| 6| 6| 7| 6|             
                             DAY ON TEST   | 3| 4| 5| 8| 6| 1| 3| 1| 3| 3| 3| 2| 1| 3| 7| 0| 1| 9| 3| 3| 0| 9| 1| 3| 6|             
                                           | 2| 1| 2| 1| 8| 0| 1| 0| 3| 1| 8| 1| 6| 3| 4| 1| 2| 6| 1| 1| 4| 3| 4| 2| 7|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    100                                    | 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 8| 8| 8| 8| 8| 8| 8|             
    NG/KG                                  | 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 4| 5| 1| 3| 4| 5| 6| 7| 9|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |                                                    +                     |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Anterior Chamber, Inflammation,      |                                                                          |             
          Suppurative                      |                                                                          |             
      Cornea, Inflammation, Suppurative    |                                                                          |             
      Retina, Atrophy                      |                         2                             2  2               |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Gross Observation           |                                  4                                       |             
      Casts Protein                        |                                                                          |             
      Cyst                                 |                                                                          |             
      Inflammation, Suppurative            |                                                             3            |             
      Mineralization                       | 1  1  1  1  1  1  1  1  1        3  1  1  1  1  1  1  1  1     1  1  1  1|             
      Nephropathy                          | 3  3  1  2  3  3  3  2  2  2  2  3  2  2  2  2  1  1  2  3  1  3  1  3  2|             
      Pelvis, Inflammation                 |                                              3                           |             
      Renal Tubule, Degeneration           |                            2                                             |             
      Transitional Epithelium, Hyperplasia |                                              4           2  2  2         |             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                              2                           |             
      Metaplasia, Squamous                 |                                              3                           |             
      Transitional Epithelium, Hyperplasia |                                              3                           |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 113                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 7| 6| 7| 6| 5| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6|             
                             DAY ON TEST   | 3| 1| 4| 6| 3| 4| 3| 7| 9| 3| 3| 2| 3| 9| 3| 5| 3| 3| 3| 3| 2| 3| 4| 3| 4|             
                                           | 2| 7| 2| 1| 2| 7| 3| 3| 8| 1| 8| 3| 1| 9| 1| 5| 1| 2| 1| 1| 2| 3| 6| 3| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    100                                    | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3|             
    NG/KG                                  | 6| 7| 8| 9| 1| 2| 3| 4| 6| 8| 9| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                 X                        |             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                    2                     |             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          2        2                                   3     1            |             
      Basophilic Focus                     | X                                                                        |             
      Basophilic Focus, Multiple           |                                                       X                  |             
      Cholangiofibrosis                    |    3        2  2  3           3  3        3  2     2  3     3  3     3  3|             
      Clear Cell Focus                     |                                           X                              |             
      Clear Cell Focus, Multiple           |                                                                          |             
      Congestion                           |                                                                          |             
      Cytoplasmic Alteration               |                                                                          |             
      Degeneration, Cystic                 |       2                                   3                    2         |             
      Eosinophilic Focus                   |                      X                                                   |             
      Eosinophilic Focus, Multiple         | X  X  X  X  X     X     X     X  X  X  X  X  X  X  X  X  X  X  X  X  X  X|             
      Fatty Change, Diffuse                | 3  1  2  2  1  2  2  2  2  1     2  2  1  2  3  2  2  2  2  2  2  2     1|             
      Fatty Change, Focal                  |                                                                      3   |             
      Hematopoietic Cell Proliferation     |                                        2                                 |             
      Hyperplasia, Nodular                 | X     X  X     X  X  X     X     X        X     X     X  X  X  X     X  X|             
      Inflammation                         | 1  1  1  1  1  1  1  1  1     2  2  1  1  3  2  1     2  1  1  2     1  2|             
      Mixed Cell Focus                     |       X                                      X           X               |             
      Mixed Cell Focus, Multiple           |                X                    X     X     X     X     X  X         |             
      Necrosis                             |       2           3  4        3  3     2     2        3                  |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 114                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 7| 6| 7| 6| 5| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6|             
                             DAY ON TEST   | 3| 1| 4| 6| 3| 4| 3| 7| 9| 3| 3| 2| 3| 9| 3| 5| 3| 3| 3| 3| 2| 3| 4| 3| 4|             
                                           | 2| 7| 2| 1| 2| 7| 3| 3| 8| 1| 8| 3| 1| 9| 1| 5| 1| 2| 1| 1| 2| 3| 6| 3| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    100                                    | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3|             
    NG/KG                                  | 6| 7| 8| 9| 1| 2| 3| 4| 6| 8| 9| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Pigmentation                         | 2  2  2  2  2  2  2  2  3  2  2  3  2  3  2  2  3  3  2  3  3  2  3  2  2|             
      Thrombosis                           |                            3                                             |             
      Toxic Hepatopathy                    | 3  3  4  3  3  3  4  3  3  3  4  4  3  3  3  4  4  4  4  4  3  4  4  4  3|             
      Artery, Inflammation, Chronic Active |                      2                                                   |             
      Bile Duct, Cyst                      |       3     2     3        4     3  3     2     2     3        3     3  2|             
      Bile Duct, Fibrosis                  |                         2                          2  2                  |             
      Bile Duct, Hyperplasia               | 2  2  3  2  2  2  3  2  2  1  3  2  2  2  2  2  2  2  2  2  2  3  3  2  2|             
      Centrilobular, Degeneration          |                                                 1                        |             
      Hepatocyte, Hypertrophy              | 3  4  4  4  3  3  3  3  3  2  4  3  3  3  3  3  3  3  3  3  4  1  4  4  3|             
      Hepatocyte, Multinucleated           | 2  2  2  2  2  1  2  2  2  2  3  1  1  2  2  1  2  2  2  2  2  2  2  2  2|             
      Oval Cell, Hyperplasia               | 3  2  3  2  2  2  3  2  2  1  3  2  2  1  3  3  3  2  2  3  2  3  2  3  2|             
      Portal, Fibrosis                     | 3     3           2  1           2     1  2  2           2     2  2  2  2|             
                                           |__________________________________________________________________________|             
   Mesentery                               |                      +        +     +        +                           |             
      Artery, Inflammation, Chronic Active |                      3        4     3                                    |             
      Fat, Necrosis                        |                                              3                           |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             |    +     +        +  +  +     +     +  +  +  +  +  +     +        +     +|             
      Gingival, Hyperplasia, Squamous      |    1              2  2  2     2     2     1     4                       1|             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         |                         1           2  2                                2|             
      Necrosis                             |                                                                          |             
      Acinus, Atrophy                      |                         3           3  2                                3|             
      Acinus, Vacuolization Cytoplasmic    | 2  3  1  2  2  2  2     1  2  1  2  2     3  1  1  1  1  3  2  2  2  1   |             
      Artery, Inflammation, Chronic Active |                               1     3                                1   |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                         3                                                |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |          1                                                               |             
      Hyperkeratosis                       |                                                                   2     2|             
      Hyperplasia, Squamous                |                         1     1                                1  2     2|             
      Inflammation                         |    1     1              2                                         2      |             
      Necrosis                             |    1                                                                     |             
      Ulcer                                |                         3                                                |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 115                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 7| 6| 7| 6| 5| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6|             
                             DAY ON TEST   | 3| 1| 4| 6| 3| 4| 3| 7| 9| 3| 3| 2| 3| 9| 3| 5| 3| 3| 3| 3| 2| 3| 4| 3| 4|             
                                           | 2| 7| 2| 1| 2| 7| 3| 3| 8| 1| 8| 3| 1| 9| 1| 5| 1| 2| 1| 1| 2| 3| 6| 3| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    100                                    | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3|             
    NG/KG                                  | 6| 7| 8| 9| 1| 2| 3| 4| 6| 8| 9| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                           |__________________________________________________________________________|             
   Tooth                                   |             +  +  +        +  +        +        +                       +|             
      Peridontal Tissue, Inflammation      |             1  1  2        2  3        1        2                       1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    1  2     1     1  2  1  1  1  1  1  1  1  1  1  1  1     1  1     1   |             
      Artery, Inflammation                 |                                                                          |             
      Artery, Thrombosis                   |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    2           1                       1     3     2                     |             
      Atrophy                              | 1  2              2           3           2  4  3        1  3        2  2|             
      Degeneration, Cystic                 |          2  2     2           2              3  3              3        2|             
      Hyperplasia                          |    2     3  2     2                 3  2  3     3  2  4  2     3     2  2|             
      Hypertrophy                          | 2  2     2  2  2  3  3  2  2  3  2  2  2  2  4  2  2  2  2  2  3  1  2  2|             
      Mineralization                       |                                                       2                  |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |          2     2  2                    2  2        2                     |             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       3           3                                                      |             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  M  M  M  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    2           3           2                    3           2            |             
      Cyst                                 |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 116                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 7| 6| 7| 6| 5| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6|             
                             DAY ON TEST   | 3| 1| 4| 6| 3| 4| 3| 7| 9| 3| 3| 2| 3| 9| 3| 5| 3| 3| 3| 3| 2| 3| 4| 3| 4|             
                                           | 2| 7| 2| 1| 2| 7| 3| 3| 8| 1| 8| 3| 1| 9| 1| 5| 1| 2| 1| 1| 2| 3| 6| 3| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    100                                    | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3|             
    NG/KG                                  | 6| 7| 8| 9| 1| 2| 3| 4| 6| 8| 9| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Inflammation, Chronic                | 2                                                                        |             
      Pars Distalis, Hyperplasia           |             2           2     2        2           2           2         |             
      Pars Intermedia, Hyperplasia         |                                     3                                    |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                           1                              |             
      Cyst                                 |                      2                                                   |             
      C-Cell, Hyperplasia                  | 2           1  1                    2        2        2  3  2  3     2   |             
      Follicular Cell, Hypertrophy         |          1  1           1  1  1              1  1        1               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |    1  1        1  1        2        1     1     1  1     1     1     1  2|             
      Duct, Cyst                           | 2  2  3  2  1  3  2  2  2  1  2  1  3  2  2  2  2  3  3  4     3     2  3|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          4     4  4     4  4  4  4  4  4     4  4  4     3  4     4     4|             
      Cyst                                 |          2  2     3     3              3        2     3              3   |             
      Inflammation, Chronic Active         |                                                                          |             
      Artery, Inflammation, Chronic Active |                      3                                                   |             
                                           |__________________________________________________________________________|             
   Oviduct                                 |                                                       +                  |             
      Inflammation                         |                                                       4                  |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         |                         4                                                |             
      Inflammation, Suppurative            |       2                       3  2              3                        |             
      Metaplasia, Squamous                 |          2           2  3     3     2              2  2     1     2     1|             
      Endometrium, Hyperplasia, Cystic     | 1  1           2  3        3     4        3     3  2     2  2           2|             
                                           |__________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 117                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 7| 6| 7| 6| 5| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6|             
                             DAY ON TEST   | 3| 1| 4| 6| 3| 4| 3| 7| 9| 3| 3| 2| 3| 9| 3| 5| 3| 3| 3| 3| 2| 3| 4| 3| 4|             
                                           | 2| 7| 2| 1| 2| 7| 3| 3| 8| 1| 8| 3| 1| 9| 1| 5| 1| 2| 1| 1| 2| 3| 6| 3| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    100                                    | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3|             
    NG/KG                                  | 6| 7| 8| 9| 1| 2| 3| 4| 6| 8| 9| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia                          | 3  2  3  3  3     2  2  3  3  4  3     3  2           2  3  3  2     3  3|             
                                           |__________________________________________________________________________|             
   Lymph Node                              |             +     +  +  +                                         +      |             
      Mediastinal, Ectasia                 |                                                                   2      |             
      Mediastinal, Hemorrhage              |                      2  2                                                |             
      Mediastinal, Hyperplasia, Histiocytic|                         2                                                |             
      Mediastinal, Pigmentation            |                                                                   2      |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |             2                                   2              3     3   |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             | 2              2                    2     3     2  2     2              2|             
      Inflammation, Suppurative            |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                              2                           |             
      Hyperplasia, Histiocytic             |                         2                                                |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 1     2  1  2  1  2     2  2  3     2  2  1  1  2     1  1  2  1     1  2|             
      Hyperplasia, Lymphoid                |       2     2                                                           2|             
      Pigmentation                         | 1  2     1  1  2  1  2  1  1     2  1  1  1  2  2  2  1  2  1  1  2  1  2|             
      Lymphoid Follicle, Atrophy           |                                                                          |             
                                           |__________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  M  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Atrophy                              | 4  3  4     4  3  4        4  3  4  4  4  4  4  4  4     4  4  4  4  4  4|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          | 2     3                                               1        1         |             
      Inflammation, Granulomatous          |                3                                                         |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 118                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 7| 6| 7| 6| 5| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6|             
                             DAY ON TEST   | 3| 1| 4| 6| 3| 4| 3| 7| 9| 3| 3| 2| 3| 9| 3| 5| 3| 3| 3| 3| 2| 3| 4| 3| 4|             
                                           | 2| 7| 2| 1| 2| 7| 3| 3| 8| 1| 8| 3| 1| 9| 1| 5| 1| 2| 1| 1| 2| 3| 6| 3| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    100                                    | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3|             
    NG/KG                                  | 6| 7| 8| 9| 1| 2| 3| 4| 6| 8| 9| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                X         |             
      Inflammation, Chronic Active         |                                                                          |             
      Epidermis, Inflammation              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |__________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fracture                             |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                2         |             
      Glial Cell, Hyperplasia              |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    | 2  2  2  2  2  2  2  2  2     2  2  2  2  2  2  3  2  1  2  2  2     2  2|             
      Inflammation, Chronic Active         |                                                                          |             
      Metaplasia, Squamous                 |          2                                                               |             
      Mineralization                       |                      2                                                   |             
      Necrosis                             |                                                                          |             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Bronchiolar                     |    3  2  2  2  2  3  1  1     3  3  1     2  1  2  3  1  2  2  3     2  2|             
                                           |__________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                            3  4           2              1               |             
      Nasopharyngeal Duct, Inflammation    |                               4                                          |             
      Olfactory Epithelium, Inflammation   |                                                    2                     |             
      Septum, Hyperplasia, Squamous        |                            2                                             |             
      Septum, Inflammation                 |                            3  4                                          |             
      Turbinate, Hyperplasia, Squamous     |                            2                                             |             
      Turbinate, Septum, Inflammation      |          2                                                               |             
                                           |__________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 119                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 5| 7| 6| 7| 6| 5| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 6|             
                             DAY ON TEST   | 3| 1| 4| 6| 3| 4| 3| 7| 9| 3| 3| 2| 3| 9| 3| 5| 3| 3| 3| 3| 2| 3| 4| 3| 4|             
                                           | 2| 7| 2| 1| 2| 7| 3| 3| 8| 1| 8| 3| 1| 9| 1| 5| 1| 2| 1| 1| 2| 3| 6| 3| 1|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    100                                    | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 3| 3|             
    NG/KG                                  | 6| 7| 8| 9| 1| 2| 3| 4| 6| 8| 9| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 5| 6| 7| 8|             
 __________________________________________|__________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Anterior Chamber, Inflammation,      |                                                                          |             
          Suppurative                      |                                                          4               |             
      Cornea, Inflammation, Suppurative    |                                                          4               |             
      Retina, Atrophy                      | 3                 3                             2                        |             
                                           |__________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         | 1  1                                      1                       1     2|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Gross Observation           |                                                                          |             
      Casts Protein                        |                                        1                                 |             
      Cyst                                 |                         2                                                |             
      Inflammation, Suppurative            |                      3                                                   |             
      Mineralization                       | 1     1  1     1     2  1     1     1     1  1     1  1  1  1  1  1     1|             
      Nephropathy                          | 2  2  2  1  3  2  3  2  2  1  3  2  3     3  2  3  2  2  2  2  2  2  3  2|             
      Pelvis, Inflammation                 |                                                 3                        |             
      Renal Tubule, Degeneration           |                                                                          |             
      Transitional Epithelium, Hyperplasia | 1                          1           1  1     4     1                 1|             
                                           |__________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                 2        1               |             
      Metaplasia, Squamous                 |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                 2                        |             
 __________________________________________|__________________________________________________________________________              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 120                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6|                                                                 |            |
                             DAY ON TEST   | 3| 8| 4|                                                                 |            |
                                           | 3| 0| 8|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 6| 6| 6|                                                                 |      A     |
    100                                    | 4| 4| 4|                                                                 |      L     |
    NG/KG                                  | 1| 2| 4|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Esophagus                               | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  M  +                                                                  |  51        |
      Parasite Metazoan                    |       X                                                                  |      2     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +                                                                  |  53        |
      Parasite Metazoan                    | X                                                                        |      1     |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  M  +                                                                  |  51        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +                                                                  |  53        |
      Cyst                                 |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  M  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  M  +                                                                  |  51        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |      5  2.0|
      Basophilic Focus                     |       X                                                                  |      3     |
      Basophilic Focus, Multiple           |                                                                          |      5     |
      Cholangiofibrosis                    | 3  3                                                                     |     31  2.4|
      Clear Cell Focus                     |                                                                          |      1     |
      Clear Cell Focus, Multiple           |                                                                          |      1     |
      Congestion                           |                                                                          |      2  2.0|
      Cytoplasmic Alteration               | 2                                                                        |      2  2.0|
      Degeneration, Cystic                 |                                                                          |      4  2.3|
      Eosinophilic Focus                   |                                                                          |      2     |
      Eosinophilic Focus, Multiple         | X     X                                                                  |     42     |
      Fatty Change, Diffuse                | 3  1  3                                                                  |     48  1.9|
      Fatty Change, Focal                  |                                                                          |      2  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.0|
      Hyperplasia, Nodular                 |    X  X                                                                  |     36     |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 121                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6|                                                                 |            |
                             DAY ON TEST   | 3| 8| 4|                                                                 |            |
                                           | 3| 0| 8|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 6| 6| 6|                                                                 |      A     |
    100                                    | 4| 4| 4|                                                                 |      L     |
    NG/KG                                  | 1| 2| 4|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
      Inflammation                         | 1  1  2                                                                  |     49  1.3|
      Mixed Cell Focus                     |                                                                          |      4     |
      Mixed Cell Focus, Multiple           | X                                                                        |     17     |
      Necrosis                             |       2                                                                  |     17  2.5|
      Pigmentation                         | 2  2  2                                                                  |     53  2.2|
      Thrombosis                           |                                                                          |      1  3.0|
      Toxic Hepatopathy                    | 4  3  4                                                                  |     53  3.5|
      Artery, Inflammation, Chronic Active |                                                                          |      2  2.0|
      Bile Duct, Cyst                      | 4                                                                        |     21  2.9|
      Bile Duct, Fibrosis                  |                                                                          |      4  1.8|
      Bile Duct, Hyperplasia               | 2  2  2                                                                  |     53  2.1|
      Centrilobular, Degeneration          |       2                                                                  |      5  2.0|
      Hepatocyte, Hypertrophy              | 3  4  4                                                                  |     52  3.2|
      Hepatocyte, Multinucleated           | 2  2  1                                                                  |     51  1.8|
      Oval Cell, Hyperplasia               | 2  2  3                                                                  |     53  2.3|
      Portal, Fibrosis                     | 1  2  2                                                                  |     27  2.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   8        |
      Artery, Inflammation, Chronic Active |                                                                          |      7  2.7|
      Fat, Necrosis                        |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Oral Mucosa                             |    +                                                                     |  29        |
      Gingival, Hyperplasia, Squamous      |                                                                          |     16  2.3|
                                           |__________________________________________________________________________|____________|
   Pancreas                                | +  +  +                                                                  |  51        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      6  2.0|
      Necrosis                             |                                                                          |      1  2.0|
      Acinus, Atrophy                      |                                                                          |      9  2.2|
      Acinus, Vacuolization Cytoplasmic    | 1  1  1                                                                  |     42  1.8|
      Artery, Inflammation, Chronic Active |                                                                          |      7  2.3|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +                                                                  |  52        |
      Inflammation                         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 122                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6|                                                                 |            |
                             DAY ON TEST   | 3| 8| 4|                                                                 |            |
                                           | 3| 0| 8|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 6| 6| 6|                                                                 |      A     |
    100                                    | 4| 4| 4|                                                                 |      L     |
    NG/KG                                  | 1| 2| 4|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +                                                                  |  53        |
      Edema                                |                                                                          |      1  1.0|
      Hyperkeratosis                       |                                                                          |      3  2.0|
      Hyperplasia, Squamous                |                                                                          |     11  1.7|
      Inflammation                         |                                                                          |      5  1.8|
      Necrosis                             |                                                                          |      1  1.0|
      Ulcer                                |                                                                          |      4  2.5|
                                           |__________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +                                                                  |  53        |
      Ulcer                                |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                                                                          |  18        |
      Peridontal Tissue, Inflammation      |                                                                          |     18  1.6|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +                                                                  |  53        |
                                           |__________________________________________________________________________|____________|
   Heart                                   | +  +  +                                                                  |  52        |
      Cardiomyopathy                       |       1                                                                  |     36  1.3|
      Artery, Inflammation                 |                                                                          |      1  1.0|
      Artery, Thrombosis                   |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +                                                                  |  53        |
      Angiectasis                          |                                                                          |     11  1.7|
      Atrophy                              | 2  2  3                                                                  |     27  2.4|
      Degeneration, Cystic                 |    2  3                                                                  |     17  2.3|
      Hyperplasia                          | 2                                                                        |     30  2.5|
      Hypertrophy                          | 2  2  1                                                                  |     47  2.4|
      Mineralization                       |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 123                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6|                                                                 |            |
                             DAY ON TEST   | 3| 8| 4|                                                                 |            |
                                           | 3| 0| 8|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 6| 6| 6|                                                                 |      A     |
    100                                    | 4| 4| 4|                                                                 |      L     |
    NG/KG                                  | 1| 2| 4|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Vacuolization Cytoplasmic            |                                                                          |     15  2.1|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +                                                                  |  53        |
      Hyperplasia                          |                                                                          |      9  1.9|
                                           |__________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +                                                                  |  52        |
                                           |__________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +                                                                  |  45        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +                                                                  |  52        |
      Angiectasis                          |    2                                                                     |      9  2.1|
      Cyst                                 |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia           |                                                                          |     19  1.7|
      Pars Intermedia, Hyperplasia         |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +                                                                  |  52        |
      Angiectasis                          |                                                                          |      1  1.0|
      Cyst                                 |                                                                          |      1  2.0|
      C-Cell, Hyperplasia                  | 1                                                                        |     23  1.9|
      Follicular Cell, Hypertrophy         |       1                                                                  |     17  1.2|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +                                                                  |  53        |
      Inflammation                         | 2  1  1                                                                  |     26  1.3|
      Duct, Cyst                           | 3  2  2                                                                  |     48  2.3|
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +                                                                  |  53        |
      Atrophy                              |       4                                                                  |     31  3.9|
      Cyst                                 |                                                                          |     13  2.5|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 124                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6|                                                                 |            |
                             DAY ON TEST   | 3| 8| 4|                                                                 |            |
                                           | 3| 0| 8|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 6| 6| 6|                                                                 |      A     |
    100                                    | 4| 4| 4|                                                                 |      L     |
    NG/KG                                  | 1| 2| 4|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 GENITAL SYSTEM - cont                     |                                                                          |            |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |   1        |
      Inflammation                         |                                                                          |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +                                                                  |  53        |
      Cyst                                 |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      5  2.2|
      Metaplasia, Squamous                 |                                                                          |     17  1.7|
      Endometrium, Hyperplasia, Cystic     |                                                                          |     19  2.1|
                                           |__________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +                                                                  |  53        |
      Atrophy                              |                                                                          |      1  4.0|
      Hyperplasia                          | 3  3  2                                                                  |     43  2.8|
                                           |__________________________________________________________________________|____________|
   Lymph Node                              |       +                                                                  |   9        |
      Mediastinal, Ectasia                 |       2                                                                  |      3  2.0|
      Mediastinal, Hemorrhage              |       2                                                                  |      5  2.2|
      Mediastinal, Hyperplasia, Histiocytic|                                                                          |      1  2.0|
      Mediastinal, Pigmentation            |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +                                                                  |  52        |
      Ectasia                              |                                                                          |      6  2.7|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
      Hyperplasia, Plasma Cell             | 2                                                                        |     16  2.3|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 125                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6|                                                                 |            |
                             DAY ON TEST   | 3| 8| 4|                                                                 |            |
                                           | 3| 0| 8|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 6| 6| 6|                                                                 |      A     |
    100                                    | 4| 4| 4|                                                                 |      L     |
    NG/KG                                  | 1| 2| 4|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
   Lymph Node, Mesenteric                  | +  M  +                                                                  |  51        |
      Ectasia                              |                                                                          |      1  2.0|
      Hyperplasia, Histiocytic             |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +                                                                  |  52        |
      Hematopoietic Cell Proliferation     | 1     1                                                                  |     43  1.5|
      Hyperplasia, Lymphoid                |                                                                          |      4  2.0|
      Pigmentation                         | 2  1  1                                                                  |     47  1.4|
      Lymphoid Follicle, Atrophy           |                                                                          |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  M                                                                  |  42        |
      Atrophy                              | 4  4                                                                     |     42  3.9|
      Cyst                                 |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +                                                                  |  53        |
      Cyst                                 |                                                                          |      1  2.0|
      Hyperplasia                          | 1     1                                                                  |     16  1.5|
      Inflammation, Granulomatous          |                                                                          |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +                                                                  |  53        |
      Cyst Epithelial Inclusion            |                                                                          |      2  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Epidermis, Inflammation              |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Bone                                    | +  +  +                                                                  |  53        |
      Fracture                             |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Brain                                   | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 126                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6|                                                                 |            |
                             DAY ON TEST   | 3| 8| 4|                                                                 |            |
                                           | 3| 0| 8|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 6| 6| 6|                                                                 |      A     |
    100                                    | 4| 4| 4|                                                                 |      L     |
    NG/KG                                  | 1| 2| 4|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 NERVOUS SYSTEM - cont                     |                                                                          |            |
      Mineralization                       |                                                                          |      2  2.0|
      Glial Cell, Hyperplasia              |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +                                                                  |  52        |
      Hemorrhage                           |                                                                          |      2  2.5|
      Infiltration Cellular, Histiocyte    | 2  2  1                                                                  |     50  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Metaplasia, Squamous                 |                                                                          |      6  2.2|
      Mineralization                       |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  4.0|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Bronchiolar                     | 1     1                                                                  |     46  2.0|
                                           |__________________________________________________________________________|____________|
   Nose                                    | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |      4  2.5|
      Nasopharyngeal Duct, Inflammation    |                                                                          |      1  4.0|
      Olfactory Epithelium, Inflammation   |                                                                          |      1  2.0|
      Septum, Hyperplasia, Squamous        |                                                                          |      1  2.0|
      Septum, Inflammation                 |                                                                          |      2  3.5|
      Turbinate, Hyperplasia, Squamous     |                                                                          |      1  2.0|
      Turbinate, Septum, Inflammation      |                                                                          |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Trachea                                 | +  +  +                                                                  |  53        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                           |__________________________________________________________________________|____________|
   Eye                                     | +  +  +                                                                  |  53        |
      Anterior Chamber, Inflammation,      |                                                                          |            |
          Suppurative                      |                                                                          |      1  4.0|
      Cornea, Inflammation, Suppurative    |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                             Page 127                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 6|                                                                 |            |
                             DAY ON TEST   | 3| 8| 4|                                                                 |            |
                                           | 3| 0| 8|                                                                 |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0|                                                                 |      O     |
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0|                                                                 |      T     |
                               ANIMAL ID   | 6| 6| 6|                                                                 |      A     |
    100                                    | 4| 4| 4|                                                                 |      L     |
    NG/KG                                  | 1| 2| 4|                                                                 |            |
 _____________________________________________________________________________________________________________________|____________|
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
      Retina, Atrophy                      |                                                                          |      6  2.3|
                                           |__________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +                                                                  |  53        |
      Inflammation                         |    2                                                                     |      6  1.3|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +                                                                  |  53        |
      Calculus Gross Observation           |                                                                          |      1  4.0|
      Casts Protein                        |                                                                          |      1  1.0|
      Cyst                                 |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      2  3.0|
      Mineralization                       | 1  1  1                                                                  |     42  1.1|
      Nephropathy                          | 2  3  2                                                                  |     52  2.2|
      Pelvis, Inflammation                 |                                                                          |      2  3.0|
      Renal Tubule, Degeneration           |                                                                          |      1  2.0|
      Transitional Epithelium, Hyperplasia |                                                                          |     11  1.8|
                                           |__________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +                                                                  |  53        |
      Inflammation                         |                                                                          |      3  1.7|
      Metaplasia, Squamous                 |                                                                          |      1  3.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
                                                                                                                                    
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page 128                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 6| 6| 4| 7| 7| 7| 6| 4| 7| 7| 6| 7| 4| 6| 7| 7| 2| 3| 7| 7| 6|             
                             DAY ON TEST   | 3| 0| 3| 7| 5| 7| 8| 2| 3| 3| 4| 1| 3| 3| 2| 2| 7| 4| 3| 3| 1| 9| 3| 3| 1|             
                                           | 3| 2| 1| 8| 3| 3| 4| 6| 1| 1| 3| 0| 1| 2| 9| 6| 4| 5| 2| 2| 5| 4| 3| 2| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    100 NG/                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    KG/STOP                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                         1|             
                                           |__________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                    X                     |             
                                           |__________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                         2                                                |             
                                           |__________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                         2                                                |             
      Atypia Cellular                      |                         1                                                |             
      Basophilic Focus                     |             X                       X        X     X                     |             
      Basophilic Focus, Multiple           | X  X                 X  X  X                                         X   |             
      Cholangiofibrosis                    |                                                                          |             
      Clear Cell Focus                     | X     X                    X                                             |             
      Clear Cell Focus, Multiple           |                                     X                                    |             
      Cytoplasmic Alteration               |                                     1                                    |             
      Eosinophilic Focus                   |                            X                 X  X                       X|             
      Eosinophilic Focus, Multiple         | X        X  X  X     X           X                 X  X  X  X     X      |             
      Fatty Change, Diffuse                |    1        1              1              2                              |             
      Fatty Change, Focal                  | 1     1              1              1              2     1               |             
      Hematopoietic Cell Proliferation     |                                                                      2   |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation                         | 1     1     2  1  3  1  1  1  1  1  1  1  2  1  1  1  1  1  1     1  2  1|             
      Mixed Cell Focus                     |                                                                          |             
      Mixed Cell Focus, Multiple           | X     X        X           X        X  X     X  X  X  X  X        X      |             
      Necrosis                             |                   3  1                       1              1        2   |             
      Pigmentation                         | 2  2  2  2  2  2  2  1  2  2  2  2  2  2  2  1  1  1  2  2  3     2  2  2|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 129                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 6| 6| 4| 7| 7| 7| 6| 4| 7| 7| 6| 7| 4| 6| 7| 7| 2| 3| 7| 7| 6|             
                             DAY ON TEST   | 3| 0| 3| 7| 5| 7| 8| 2| 3| 3| 4| 1| 3| 3| 2| 2| 7| 4| 3| 3| 1| 9| 3| 3| 1|             
                                           | 3| 2| 1| 8| 3| 3| 4| 6| 1| 1| 3| 0| 1| 2| 9| 6| 4| 5| 2| 2| 5| 4| 3| 2| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    100 NG/                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    KG/STOP                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
      Toxic Hepatopathy                    | 1  2  1     2  1     1  1  2        1  1  2              1  2        1   |             
      Vacuolization Cytoplasmic            |                                                       1                  |             
      Bile Duct, Cyst                      |    3                          2                       2  2           3   |             
      Bile Duct, Fibrosis                  |    1  1                             1  2                 1               |             
      Bile Duct, Hyperplasia               |    1                                         1              1        1   |             
      Hepatocyte, Hypertrophy              | 2  3  2  1  2  1     2  1  1        2  1        1           3  3         |             
      Hepatocyte, Multinucleated           | 1  1  1     2  1     1  1  1  1     1  2  2  1  1  1  1  1  3     2  1  1|             
      Oval Cell, Hyperplasia               |                                                                      1   |             
      Portal, Fibrosis                     |                                           2                              |             
      Serosa, Inflammation, Chronic Active |                         3                                                |             
                                           |__________________________________________________________________________|             
   Mesentery                               |                                                             +            |             
      Artery, Inflammation, Chronic Active |                                                             3            |             
                                           |__________________________________________________________________________|             
   Oral Mucosa                             | +  +                          +                                          |             
      Gingival, Hyperplasia, Squamous      | 2                             2                                          |             
                                           |__________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                                  1                                       |             
      Inflammation, Chronic Active         |                1                    1                                    |             
      Acinus, Atrophy                      |                1                    2                                    |             
      Artery, Inflammation, Chronic Active |                                                             3            |             
                                           |__________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    2                                                                     |             
      Fibrosis                             |                                                                          |             
      Inflammation                         |                                                                          |             
                                           |__________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Squamous                |                                                 2                        |             
      Inflammation                         |                                                 2                        |             
      Ulcer                                |                   2                             3                        |             
                                           |__________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 130                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 6| 6| 4| 7| 7| 7| 6| 4| 7| 7| 6| 7| 4| 6| 7| 7| 2| 3| 7| 7| 6|             
                             DAY ON TEST   | 3| 0| 3| 7| 5| 7| 8| 2| 3| 3| 4| 1| 3| 3| 2| 2| 7| 4| 3| 3| 1| 9| 3| 3| 1|             
                                           | 3| 2| 1| 8| 3| 3| 4| 6| 1| 1| 3| 0| 1| 2| 9| 6| 4| 5| 2| 2| 5| 4| 3| 2| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    100 NG/                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    KG/STOP                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
   Tongue                                  |    +                                                                     |             
      Inflammation, Chronic Active         |    3                                                                     |             
                                           |__________________________________________________________________________|             
   Tooth                                   | +  +              +     +     +                                          |             
      Peridontal Tissue, Inflammation      | 1  1              3     3     2                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |__________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |             1                 2     1     3  1        1  2           1  1|             
      Inflammation                         |                   2                                                      |             
      Atrium, Thrombosis                   |                   3                                                      |             
      Epicardium, Inflammation, Chronic    |                                                                          |             
          Active                           |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       2                    2        1  1     1           2               |             
      Atrophy                              |                         3                                                |             
      Degeneration, Cystic                 |    3     1           2  2  1  3        2     2  1                        |             
      Hyperplasia                          |          3  2  3     3                 2                             2   |             
      Hypertrophy                          | 2  3  1  1  2  2     2  3  3  3  2  2  2  2  3  2  2  2  3  1  1  3  2  1|             
      Necrosis                             |          3                    3                                          |             
      Vacuolization Cytoplasmic            |                1                                         1              1|             
                                           |__________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2  2     2        2                          2  2  2              2|             
                                           |__________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                           |__________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +|             
                                           |__________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 1  2                       1                 1                    2     3|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 131                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 6| 6| 4| 7| 7| 7| 6| 4| 7| 7| 6| 7| 4| 6| 7| 7| 2| 3| 7| 7| 6|             
                             DAY ON TEST   | 3| 0| 3| 7| 5| 7| 8| 2| 3| 3| 4| 1| 3| 3| 2| 2| 7| 4| 3| 3| 1| 9| 3| 3| 1|             
                                           | 3| 2| 1| 8| 3| 3| 4| 6| 1| 1| 3| 0| 1| 2| 9| 6| 4| 5| 2| 2| 5| 4| 3| 2| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    100 NG/                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    KG/STOP                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
      Cytoplasmic Alteration               |                      2                                                   |             
      Vacuolization Cytoplasmic            |                1        2                                                |             
      Pars Distalis, Hyperplasia           | 2        2     2     1  1              1           2  2           3  2   |             
                                           |__________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                              2                           |             
      C-Cell, Hyperplasia                  |       3  2                    2  1                    1                  |             
      Follicular Cell, Hypertrophy         | 1           3                                   1                    1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |__________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             2                                                            |             
      Hyperplasia, Basal Cell              |                                                          1               |             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation                         | 2  1  1     1     1  2     2        2        1  1  2  2  2  1  1  2      |             
      Duct, Cyst                           | 3  3  3     3  1  3     2                 3  1     1  2     1  2        2|             
                                           |__________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4  4  4  4  4  4  4  4  4  4  4     4  4  4  3  4  4  4  4     4  4  4  4|             
      Cyst                                 |       2     2        2        2        2     2        2           3      |             
      Inflammation, Granulomatous          |                                                                          |             
                                           |__________________________________________________________________________|             
   Oviduct                                 |                               +                                      +   |             
      Inflammation                         |                               3                                      3   |             
                                           |__________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                   2     3              3  4        2     1        3     2|             
      Metaplasia, Squamous                 | 2     1  1  2  2  3        2  4        3  2     2  2  2  2     1  3  3  2|             
      Cervix, Inflammation, Chronic Active |    3                                                                     |             
      Endometrium, Hyperplasia, Cystic     | 2  1  2  2  2        1  2  2        3  1     1  4  2  2  2        2     4|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |__________________________________________________________________________|             
 __________________________________________|__________________________________________________________________________|             
                                                                                                                                    
                                                                                                                                    
                                                             Page 132                                                               
                                                                                                                                   
NTP Experiment-Test: 96007-03                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: CHRONIC                             TOXIC EQUIVALENCY FACTOR EVALUATION (TCDD)                        Date: 09/30/03    
Route: GAVAGE                                                                                                     Time: 08:37:20    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 6| 6| 4| 7| 7| 7| 6| 4| 7| 7| 6| 7| 4| 6| 7| 7| 2| 3| 7| 7| 6|             
                             DAY ON TEST   | 3| 0| 3| 7| 5| 7| 8| 2| 3| 3| 4| 1| 3| 3| 2| 2| 7| 4| 3| 3| 1| 9| 3| 3| 1|             
                                           | 3| 2| 1| 8| 3| 3| 4| 6| 1| 1| 3| 0| 1| 2| 9| 6| 4| 5| 2| 2| 5| 4| 3| 2| 4|             
 __________________________________________|__________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   SPRAGUE-DAWLEY RATS FEMALE              | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    100 NG/                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    KG/STOP                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 __________________________________________|__________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia                          | 2  3  2  3  3  3  4  2  3     3  3        3  3  4  4     2  4  3     4  3|             
      Myelofibrosis                        |                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node                              |                                                 +                        |             
      Lumbar, Ectasia                      |                                                                          |             
      Lumbar, Hyperplasia, Plasma Cell     |                                                 2                        |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                          3               |             
      Hyperplasia, Lymphoid                |                                        2                                 |             
      Hyperplasia, Plasma Cell             | 3  3  2     2  2     2  3  3  2  1  2        2  2  2  3           3  3   |             
                                           |__________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Histiocytic             |             3                                                            |             
                                           |__________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 1     1  2  1  2     1  1  1     2  1  1  2  2  3  2  1  1  1  3  1  3  3|             
      Hyperplasia, Lymphoid                |             2                                                            |             
      Pigmentation                         | 2  3  2  1  1  1     1  1  2  2  1  2  2  2  1     1  2  2  1     2  1   |             
      Lymphoid Follicle, Atrophy           |                                                                          |             
      Red Pulp,