TDMS Study 96007-04 Pathology Tables
NTP Experiment-Test: 96007-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/22/03
Route: GAVAGE TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Time: 10:47:09
53 WEEK SSAC/FINAL#1
Facility: Battelle Columbus Laboratory
Chemical CAS #: TEFDIOXINMIX
Lock Date: 09/12/01
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 06/16/99 - 06/19/99
Treatment Groups: Include 001 TERT.MIXCONTROL
Include 002 TERT.MIXTEQ=10
Include 003 TERT.MIXTEQ=22
Include 004 TERT.MIXTEQ=46
Include 005 TERT.MIXTEQ=100
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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NTP Experiment-Test: 96007-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/22/03
Route: GAVAGE TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Time: 10:47:09
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SPRAGUE-DAWLEY RATS FEMALE TERT.MIX TERT.MIX TERT.MIX TERT.MIX TERT.MIX
CONTROL TEQ=10 TEQ=22 TEQ=46 TEQ=100
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DISPOSITION SUMMARY
Animals Initially In Study 98 98 98 98 98
Scheduled Sacrifice 13 13 13 13 13
Early Deaths
Survivors
Animals Examined Microscopically 8 8 8 8 8
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ALIMENTARY SYSTEM
Liver (8) (8) (8) (8) (8)
Basophilic Focus 1 1
Cholangiofibrosis 2 [1.0] 1 [1.0]
Clear Cell Focus 1 1 1
Eosinophilic Focus 1 1
Eosinophilic Focus, Multiple 1
Fatty Change, Diffuse 2 [1.0]
Fatty Change, Focal 3 [1.0] 4 [1.3]
Inflammation 8 [1.0] 8 [1.0] 8 [1.1] 8 [1.4] 8 [1.9]
Mixed Cell Focus 2 2 4 1
Mixed Cell Focus, Multiple 1 2 3 5 7
Pigmentation 4 [1.0] 8 [1.3] 8 [1.0] 8 [2.0]
Regeneration 1
Toxic Hepatopathy 3 [1.3] 8 [1.6]
Bile Duct, Fibrosis 1 [1.0]
Bile Duct, Hyperplasia 6 [1.0]
Bile Duct, Inflammation, Chronic Active 1 [1.0] 1 [1.0]
Hepatocyte, Hypertrophy 5 [1.2] 7 [1.4] 8 [1.5] 8 [2.5]
Hepatocyte, Multinucleated 3 [1.0] 8 [1.8]
Pancreas (8) (8) (8) (8) (8)
Basophilic Focus 1
Inflammation, Chronic Active 1 [3.0] 1 [1.0]
Acinus, Atrophy 1 [2.0] 1 [2.0]
Acinus, Vacuolization Cytoplasmic 2 [1.0] 7 [1.6]
Stomach, Glandular (8) (1) (8)
Cyst, Squamous 1 [1.0]
Developmental Malformation 1 [2.0]
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CARDIOVASCULAR SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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NTP Experiment-Test: 96007-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/22/03
Route: GAVAGE TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Time: 10:47:09
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE TERT.MIX TERT.MIX TERT.MIX TERT.MIX TERT.MIX
CONTROL TEQ=10 TEQ=22 TEQ=46 TEQ=100
____________________________________________________________________________________________________________________________________
None
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ENDOCRINE SYSTEM
Adrenal Cortex (8) (8) (8) (8) (8)
Degeneration, Cystic 1 [2.0] 2 [1.5]
Hyperplasia 2 [2.0] 1 [1.0] 2 [2.0]
Hypertrophy 3 [1.7] 7 [1.0] 5 [1.0] 3 [1.0] 5 [1.6]
Vacuolization Cytoplasmic 1 [1.0]
Thyroid Gland (8) (8) (8) (8) (8)
C-Cell, Hyperplasia 1 [1.0]
Follicular Cell, Hypertrophy 2 [1.0] 2 [1.5] 3 [1.0] 3 [1.7] 4 [2.3]
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Ovary (8) (8) (8) (8) (8)
Atrophy 8 [3.9] 8 [4.0] 8 [4.0] 6 [4.0] 8 [3.8]
Cyst 1 [2.0]
Inflammation, Suppurative 1 [3.0]
Uterus (8) (8) (8) (8) (8)
Inflammation, Suppurative 1 [1.0]
Metaplasia, Squamous 8 [2.1] 8 [2.1] 8 [2.1] 6 [2.5] 7 [2.1]
Endometrium, Hyperplasia, Cystic 6 [1.7] 2 [4.0]
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HEMATOPOIETIC SYSTEM
Spleen (8) (8)
Pigmentation 8 [1.6] 8 [2.1]
Thymus (8) (8) (8) (8) (6)
Atrophy 3 [2.0] 7 [1.7] 8 [2.0] 8 [3.4] 6 [3.7]
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INTEGUMENTARY SYSTEM
Mammary Gland (8) (1) (1) (1) (8)
Cyst 3 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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NTP Experiment-Test: 96007-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 04/22/03
Route: GAVAGE TOXIC EQUIVALENCY FACTOR EVALUATION (DIOXIN MIXTURE) Time: 10:47:09
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE TERT.MIX TERT.MIX TERT.MIX TERT.MIX TERT.MIX
CONTROL TEQ=10 TEQ=22 TEQ=46 TEQ=100
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INTEGUMENTARY SYSTEM - CONT
Hyperplasia 1 [1.0] 1 [1.0]
Skin (1)
Ulcer 1 [2.0]
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MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
None
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RESPIRATORY SYSTEM
Lung (8) (8) (8) (8) (8)
Infiltration Cellular, Histiocyte 6 [1.2] 5 [1.0] 5 [1.0] 4 [1.0] 6 [1.0]
Inflammation 1 [1.0]
Inflammation, Chronic Active 1 [1.0]
Alveolar Epithelium, Metaplasia, Bronchiolar 1 [1.0] 2 [1.5] 4 [1.0] 6 [1.3]
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SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
Kidney (1) (1)
Inflammation, Chronic Active 1 [2.0] 1 [3.0]
Nephropathy 1 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
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