TDMS Study 96007-05 Pathology Tables
NTP Experiment-Test: 96007-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) Date: 07/14/03
Route: GAVAGE Time: 14:48:11
31 WEEK SSAC RATS
Facility: Battelle Columbus Laboratory
Chemical CAS #: 57117-31-4
Lock Date: 07/25/02
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 11/03/99 - 11/04/99
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 96007-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) Date: 07/14/03
Route: GAVAGE Time: 14:48:11
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SPRAGUE-DAWLEY RATS FEMALE 0 NG/KG 6 NG/KG 20 NG/KG 44 NG/KG 92 NG/KG 200
NG/KG
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DISPOSITION SUMMARY
Animals Initially in Study 98 98 98 98 98 98
Scheduled Sacrifice 16 16 16 16 16 16
Early Deaths
Survivors
Animals Examined Microscopically 10 10 10 10 10 10
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ALIMENTARY SYSTEM
None
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
None
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
None
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HEMATOPOIETIC SYSTEM
None
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Page 2
NTP Experiment-Test: 96007-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) Date: 07/14/03
Route: GAVAGE Time: 14:48:11
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG/KG 6 NG/KG 20 NG/KG 44 NG/KG 92 NG/KG 200
NG/KG
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INTEGUMENTARY SYSTEM
Mammary Gland (10) (2) (1) (1) (10)
Carcinoma 1 (100%)
Fibroadenoma 1 (10%) 2 (100%)
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MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
None
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RESPIRATORY SYSTEM
None
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SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
None
Page 3
NTP Experiment-Test: 96007-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) Date: 07/14/03
Route: GAVAGE Time: 14:48:11
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG/KG 6 NG/KG 20 NG/KG 44 NG/KG 92 NG/KG 200
NG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 1 2 1
Total Primary Neoplasms 1 2 1
Total Animals with Benign Neoplasms 1 2
Total Benign Neoplasms 1 2
Total Animals with Malignant Neoplasms 1
Total Malignant Neoplasms 1
Total Animals with Metastatic Neoplasms
Total Metastatic Neoplasm
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
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a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 4
NTP Experiment-Test: 96007-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) Date: 07/14/03
Route: GAVAGE Time: 14:48:11
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 200 NG/
KG STOP
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DISPOSITION SUMMARY
Animals Initially in Study 50
Early Deaths
Survivors
Animals Examined Microscopically
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ALIMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 5
NTP Experiment-Test: 96007-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION(PECDF) Date: 07/14/03
Route: GAVAGE Time: 14:48:11
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 200 NG/
KG STOP
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
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