TDMS Study 96007-01 Pathology Tables
NTP Experiment-Test: 96007-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:22:24
31 WEEK SSAC
Facility: Battelle Columbus Laboratory
Chemical CAS #: 57465-28-8
Lock Date: 01/09/01
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 09/24/98 - 09/25/98
Treatment Groups: Include 001 0 NG/KG
Include 002 10 NG/KG
Include 003 30 NG/KG
Include 004 100 NG/KG
Include 005 175 NG/KG
Include 006 300 NG/KG
Include 007 550 NG/KG
Include 008 1000 NG/KG
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 96007-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:22:24
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG/KG 10 NG/KG 30 NG/KG 100 175 300
NG/KG NG/KG NG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 98 48 98 98 98 98
Scheduled Sacrifice 16 16 15 16 16 16
Early Deaths
Survivors
Animals Examined Microscopically 10 10 9 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (9) (10) (10) (10)
Basophilic Focus 1 (10%)
Cholangiofibrosis 1 (10%)
Clear Cell Focus 1 (10%) 1 (10%)
Degeneration, Cystic 1 (10%)
Inflammation 7 (70%) 10 (100%) 9 (100%) 10 (100%) 10 (100%) 10 (100%)
Mixed Cell Focus 2 (20%) 2 (22%) 3 (30%) 1 (10%) 1 (10%)
Mixed Cell Focus, Multiple 2 (20%) 1 (10%)
Necrosis 1 (10%)
Pigmentation 3 (30%) 5 (50%) 8 (80%)
Hepatocyte, Hypertrophy 3 (30%) 4 (44%) 6 (60%) 6 (60%) 8 (80%)
Pancreas (10) (10) (9) (10) (10) (10)
Basophilic Focus 1 (10%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (9) (10) (10) (10)
Angiectasis 1 (10%)
Degeneration, Cystic 1 (10%)
Hyperplasia 1 (11%) 1 (10%)
Hypertrophy 2 (20%) 3 (30%) 2 (22%) 3 (30%) 2 (20%) 4 (40%)
Adrenal Medulla (10)
Hyperplasia 1 (10%)
Thyroid Gland (10) (3) (3) (5) (6) (5)
Follicular Cell, Hypertrophy 3 (100%) 3 (100%) 5 (100%) 6 (100%) 5 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 96007-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:22:24
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG/KG 10 NG/KG 30 NG/KG 100 175 300
NG/KG NG/KG NG/KG
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (10) (10) (9) (10) (10) (10)
Atrophy 8 (80%) 8 (80%) 4 (44%) 10 (100%) 9 (90%) 10 (100%)
Uterus (10) (1) (1)
Inflammation, Suppurative 1 (10%) 1 (100%)
Metaplasia, Squamous 5 (50%) 1 (100%)
Endometrium, Hyperplasia, Cystic 1 (10%) 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Spleen (10)
Pigmentation 10 (100%)
Thymus (10) (10) (9) (10) (10) (10)
Atrophy 2 (20%) 3 (30%) 1 (11%) 3 (30%) 3 (30%) 3 (30%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (9) (10) (10) (10)
Infiltration Cellular, Histiocyte 2 (20%) 3 (30%) 2 (22%) 3 (30%) 1 (10%) 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 96007-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:22:24
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG/KG 10 NG/KG 30 NG/KG 100 175 300
NG/KG NG/KG NG/KG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Alveolar Epithelium, Metaplasia, Bronchiolar 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 96007-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:22:24
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 550 1000
NG/KG NG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 98 98
Scheduled Sacrifice 16 16
Early Deaths
Survivors
Animals Examined Microscopically 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10)
Cholangiofibrosis 1 (10%)
Fatty Change, Diffuse 1 (10%)
Hepatocyte, Multinucleate 2 (20%) 8 (80%)
Inflammation 10 (100%) 10 (100%)
Mixed Cell Focus 2 (20%) 2 (20%)
Mixed Cell Focus, Multiple 1 (10%) 4 (40%)
Necrosis 1 (10%) 2 (20%)
Pigmentation 8 (80%) 10 (100%)
Toxic Hepatopathy 10 (100%)
Hepatocyte, Hypertrophy 10 (100%) 10 (100%)
Pancreas (10) (10)
Inflammation, Chronic Active 1 (10%)
Acinus, Atrophy 1 (10%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10)
Hyperplasia 1 (10%)
Hypertrophy 4 (40%)
Thyroid Gland (5) (10)
Follicular Cell, Hypertrophy 5 (100%) 7 (70%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 96007-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:22:24
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 550 1000
NG/KG NG/KG
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (10) (10)
Atrophy 7 (70%) 4 (40%)
Uterus (10)
Inflammation, Suppurative 1 (10%)
Metaplasia, Squamous 4 (40%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Spleen (1) (10)
Hematopoietic Cell Proliferation 1 (100%)
Pigmentation 10 (100%)
Thymus (10) (10)
Atrophy 8 (80%) 10 (100%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10)
Infiltration Cellular, Histiocyte 1 (10%) 4 (40%)
Alveolar Epithelium, Metaplasia, Bronchiolar 2 (20%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 96007-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB-126) Date: 10/14/02
Route: GAVAGE Time: 15:22:24
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 550 1000
NG/KG NG/KG
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
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