TDMS Study 99033-01 Pathology Tables
NTP EXP/TEST: 99033-01 TRANSGENIC MODEL EVALUATION II (ASPARTAME) PAGE: 1
TEST TYPE: 26-39 WEEKS INITIAL AND CURRENT BODY WEIGHT DATE: 03/05/03
ROUTE: DOSED FEED TIME: 13:36:54
EIS REPORT 03
FINAL #3 TG.AC MICE
FACILITY: BIORELIANCE
NTP C#: C99033
CONTRACT NUMBER: N01-ES-65406
CAS NUMBER: 22839-47-0
ANIMAL SUPPLIER: TACONIC FARMS
CAGE RANGE: ALL
DATE RANGE: ALL
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE 001 VEHICLE CONTROL
INCLUDE 002 3125 PPM
INCLUDE 003 6250 PPM
INCLUDE 004 12500 PPM
INCLUDE 005 25000 PPM
INCLUDE 006 50000 PPM
INCLUDE 008 VEHICLE CONTROL
INCLUDE 009 3125 PPM
INCLUDE 010 6250 PPM
INCLUDE 011 12500 PPM
INCLUDE 012 25000 PPM
INCLUDE 013 50000 PPM
NTP EXP/TEST: 99033-01 TRANSGENIC MODEL EVALUATION II (ASPARTAME) PAGE: 2
TEST TYPE: 26-39 WEEKS INITIAL AND CURRENT BODY WEIGHT DATE: 03/05/03
ROUTE: DOSED FEED EISRPT03 TIME: 13:36:54
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SPECIES-STRAIN: TG.AC HEMI-MICE SEX: FEMALE WEEK ON DOSE: 40 FIRST DOSE: 10/11/99
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-----INITIAL----- ------------CURRENT------------- -----CHANGE------
TREATMENT N MEAN(G) SD N MEAN(G) SD % REL CNTRL N MEAN(G) SD
VEHICLE CONTROL 15 16.6 1.1 11 26.7 2.1 11 9.9 1.4
3125 PPM 15 16.6 0.6 10 25.4 1.4 95.1 10 8.7 1.2
6250 PPM 15 15.8 1.3 9 26.9 2.4 100.7 9 10.7 2.2
12500 PPM 15 15.5 2.1 9 26.5 2.5 99.2 9 10.5 2.8
25000 PPM 15 16.4 1.4 11 26.5 3.3 99.2 11 9.5 3.3
50000 PPM 15 16.6 1.0 8 28.3 2.6 105.9 8 11.7 2.5
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SPECIES-STRAIN: TG.AC HEMI-MICE SEX: MALE WEEK ON DOSE: 40 FIRST DOSE: 10/11/99
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-----INITIAL----- ------------CURRENT------------- -----CHANGE------
TREATMENT N MEAN(G) SD N MEAN(G) SD % REL CNTRL N MEAN(G) SD
VEHICLE CONTROL 15 19.1 1.9 9 32.8 1.3 9 14.1 1.6
3125 PPM 15 19.2 2.1 12 31.3 2.5 95.4 12 11.5 1.9
6250 PPM 15 19.1 1.8 8 32.1 2.3 97.8 8 13.3 2.8
12500 PPM 15 17.8 2.2 12 31.2 2.3 95.1 12 13.3 3.0
25000 PPM 15 19.1 2.0 11 31.2 3.5 95.1 11 12.2 3.7
50000 PPM 15 18.6 1.7 10 31.7 1.9 96.6 10 12.6 1.6
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