TDMS Study 99033-01 Pathology Tables
NTP FEED, WATER, AND COMPOUND CONSUMPTION TABLE REPORT: EISRPT39
LAB: BIORELIANCE TRANSGENIC MODEL EVALUATION II (ASPARTAME) DATE: 03/05/03
EXPERIMENT: 99033 TEST: 01 TIME: 13:36:34
CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: 26-39 WEEKS ROUTE: DOSED FEED NTP: C99033
------------------------------------------------------------------------------------------------------------------------------------
FINAL #3 TG.AC MICE
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE 001 VEHICLE CONTROL
INCLUDE 002 3125 PPM
INCLUDE 003 6250 PPM
INCLUDE 004 12500 PPM
INCLUDE 005 25000 PPM
INCLUDE 006 50000 PPM
INCLUDE 008 VEHICLE CONTROL
INCLUDE 009 3125 PPM
INCLUDE 010 6250 PPM
INCLUDE 011 12500 PPM
INCLUDE 012 25000 PPM
INCLUDE 013 50000 PPM
NTP FEED, WATER, AND COMPOUND CONSUMPTION TABLE REPORT: EISRPT39
LAB: BIORELIANCE TRANSGENIC MODEL EVALUATION II (ASPARTAME) DATE: 03/05/03
EXPERIMENT: 99033 TEST: 01 TIME: 13:45:21
TEST TYPE: 26 ROUTE: DOSED FEED NTP: C99033
CONT: N01-ES-65406 CAS: 22839-47-0
FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE
26 DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)
==================================================================================================================================
VEHICLE CONTROL 3125 PPM 6250 PPM 12500 PPM
---------------- --------------------------------- --------------------------------- ---------------------------------
DOSE/ DOSE/ DOSE/
GRAMS BODY GRAMS BODY CONTROL GRAMS BODY CONTROL GRAMS BODY CONTROL
FEED/ WEIGHT FEED/ WEIGHT FEED (B) DOSE/ FEED/ WEIGHT FEED (B) DOSE/ FEED/ WEIGHT FEED (B) DOSE/
WEEK DAY(A) (GRAMS) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C)
==================================================================================================================================
2 4.5 21.5 4.2 21.3 0.93 615 4.2 20.1 0.93 1304 4.3 20.3 0.96 2631
3 4.1 21.9 4.0 22.0 0.98 572 4.4 21.8 1.07 1267 4.3 21.2 1.05 2510
4 4.5 22.6 4.5 23.2 1.00 601 4.4 22.7 0.98 1204 4.3 22.3 0.96 2432
5 4.5 23.8 4.3 23.7 0.96 570 4.5 23.6 1.00 1190 4.3 23.1 0.96 2312
6 4.2 24.6 4.1 23.2 0.98 552 4.4 24.6 1.05 1129 4.2 23.5 1.00 2244
7 4.5 25.2 4.2 24.8 0.93 531 4.4 25.7 0.98 1081 4.0 23.9 0.89 2075
8 4.5 26.0 4.2 25.0 0.93 523 4.3 25.8 0.96 1031 4.2 24.8 0.93 2125
9 4.4 26.3 4.3 25.9 0.98 516 4.4 26.8 1.00 1019 4.4 25.6 1.00 2125
10 4.3 27.4 4.3 26.4 1.00 513 4.3 26.7 1.00 1007 4.3 26.1 1.00 2059
11 4.3 28.2 4.4 26.7 1.02 513 4.5 27.5 1.05 1032 4.6 26.8 1.07 2125
12 4.4 28.5 4.1 26.2 0.93 487 4.5 28.0 1.02 1015 4.3 26.6 0.98 2001
13 4.3 28.8 4.4 27.4 1.02 496 4.5 28.3 1.05 1006 4.2 27.0 0.98 1923
14 4.2 29.0 4.2 27.1 1.00 479 4.2 27.8 1.00 949 4.2 27.2 1.00 1933
15 4.2 29.5 4.5 28.5 1.07 490 4.5 29.2 1.07 966 4.2 28.0 1.00 1872
16 4.2 29.5 4.1 27.8 0.98 460 4.3 28.8 1.02 928 4.3 27.9 1.02 1923
17 4.2 29.2 4.3 27.9 1.02 486 4.3 29.1 1.02 930 4.2 28.3 1.00 1876
18 4.1 29.5 4.4 28.6 1.07 478 4.3 29.2 1.05 928 4.3 28.3 1.05 1881
19 4.1 29.1 4.4 29.4 1.07 471 4.4 29.7 1.07 926 4.2 28.2 1.02 1845
20 4.4 29.7 4.1 29.0 0.93 446 4.1 29.9 0.93 864 4.2 28.6 0.95 1851
21 4.3 30.2 4.4 29.6 1.02 469 4.5 30.3 1.05 921 4.3 29.0 1.00 1874
22 4.2 30.4 4.2 29.1 1.00 447 4.0 29.7 0.95 847 4.3 29.0 1.02 1873
23 4.3 30.8 4.2 29.1 0.98 450 4.5 29.9 1.05 948 4.4 29.2 1.02 1892
24 4.2 30.7 4.2 28.8 1.00 451 4.2 30.1 1.00 877 4.3 29.9 1.02 1780
25 4.4 31.1 4.3 29.1 0.98 461 4.3 30.5 0.98 890 4.5 30.0 1.02 1856
26 4.0 30.8 4.3 29.4 1.08 460 4.4 30.7 1.10 902 4.2 30.0 1.05 1758
27 4.3 31.3 4.4 29.4 1.02 466 4.2 30.7 0.98 861 4.1 29.7 0.95 1738
28 4.1 31.5 4.3 29.3 1.05 458 4.2 30.5 1.02 869 4.2 29.7 1.02 1785
29 4.2 31.4 4.2 28.8 1.00 460 4.0 30.0 0.95 840 4.1 30.1 0.98 1719
30 4.4 31.8 4.6 30.2 1.05 472 4.5 30.0 1.02 931 4.4 30.7 1.00 1779
31 4.5 31.5 4.6 30.4 1.02 471 4.7 30.6 1.04 968 4.6 30.5 1.02 1869
32 4.3 31.1 4.6 30.6 1.07 470 4.8 30.9 1.12 961 4.4 30.1 1.02 1830
33 4.4 31.1 4.8 30.6 1.09 494 4.7 30.8 1.07 960 4.6 30.0 1.05 1918
34 4.5 31.3 4.7 30.5 1.04 482 4.6 31.2 1.02 925 4.8 30.3 1.07 1965
35 4.5 31.6 4.6 30.6 1.02 470 4.6 30.7 1.02 928 4.7 30.8 1.04 1914
36 4.6 32.0 4.6 30.6 1.00 467 4.8 31.7 1.04 952 4.8 31.3 1.04 1896
37 4.4 32.0 4.5 30.1 1.02 464 4.7 31.9 1.07 918 4.5 30.9 1.02 1832
38 4.3 31.7 4.7 30.9 1.09 475 4.4 31.6 1.02 878 4.3 31.2 1.00 1739
39 4.2 31.8 4.6 31.1 1.10 461 4.6 31.8 1.10 898 4.5 31.3 1.07 1796
40 4.4 32.8 4.3 31.3 0.98 428 4.7 32.1 1.07 907 4.5 31.2 1.02 1802
1 TO 13 WEEKS
----------------
MEAN 4.4 25.4 4.2 24.7 0.97 541 4.4 25.1 1.01 1107 4.3 24.3 0.98 2214
SD(D) 0.1 0.1 0.03 41 0.1 0.04 109 0.1 0.05 217
CV(E) 2.9 3.1 3.6 7.6 2.7 4.2 9.8 3.2 5.0 9.8
14 TO 52 WEEKS
----------------
MEAN 4.3 30.8 4.4 29.5 1.03 466 4.4 30.3 1.03 914 4.4 29.7 1.02 1844
SD(D) 0.1 0.2 0.04 14 0.2 0.05 37 0.2 0.03 65
CV(E) 3.5 4.5 4.2 3.1 5.0 4.5 4.1 4.2 2.8 3.5
==================================================================================================================================
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE
26 DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)
=============================================================================
25000 PPM 50000 PPM
--------------------------------- ---------------------------------
DOSE/ DOSE/
GRAMS BODY CONTROL GRAMS BODY CONTROL
FEED/ WEIGHT FEED (B) DOSE/ FEED/ WEIGHT FEED (B) DOSE/
WEEK DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C)
=============================================================================
2 4.3 21.7 0.96 5005 4.1 20.8 0.91 9871
3 4.4 22.1 1.07 4998 4.2 22.0 1.02 9590
4 4.5 23.3 1.00 4808 4.3 22.7 0.96 9448
5 4.4 23.9 0.98 4642 4.3 23.6 0.96 9028
6 4.5 25.0 1.07 4540 4.1 23.8 0.98 8695
7 4.4 25.4 0.98 4375 4.2 24.9 0.93 8394
8 4.5 25.9 1.00 4332 4.1 24.6 0.91 8247
9 4.3 26.1 0.98 4168 4.3 25.5 0.98 8340
10 4.3 26.4 1.00 4027 4.3 26.2 1.00 8210
11 4.5 27.5 1.05 4056 4.4 26.8 1.02 8178
12 4.2 26.7 0.95 3968 4.3 27.0 0.98 8059
13 4.7 27.9 1.09 4170 4.4 27.4 1.02 7993
14 4.5 28.1 1.07 3985 4.4 27.6 1.05 7958
15 4.4 28.5 1.05 3876 4.2 28.1 1.00 7465
16 4.4 28.4 1.05 3841 4.1 27.8 0.98 7396
17 4.5 29.0 1.07 3879 4.2 28.6 1.00 7348
18 4.4 28.8 1.07 3779 4.2 28.6 1.02 7423
19 4.5 29.3 1.10 3840 4.3 28.4 1.05 7611
20 4.2 29.9 0.95 3479 4.1 28.9 0.93 7128
21 4.2 29.6 0.98 3584 4.2 29.4 0.98 7092
22 4.4 29.4 1.05 3724 3.9 28.5 0.93 6829
23 4.5 29.7 1.05 3766 4.2 28.4 0.98 7373
24 4.4 30.0 1.05 3635 4.4 27.9 1.05 7866
25 4.5 29.6 1.02 3820 4.0 28.0 0.91 7176
26 4.5 30.3 1.13 3724 4.0 27.2 1.00 7385
27 4.5 30.5 1.05 3668 4.1 29.0 0.95 7075
28 4.6 30.7 1.12 3713 4.2 29.7 1.02 7085
29 4.5 30.9 1.07 3622 4.1 30.0 0.98 6796
30 4.6 31.1 1.05 3669 4.3 30.9 0.98 6998
31 4.8 31.0 1.07 3854 4.6 30.9 1.02 7479
32 4.7 31.3 1.09 3756 4.3 31.0 1.00 6938
33 4.5 31.1 1.02 3591 4.5 31.2 1.02 7174
34 4.8 30.8 1.07 3862 4.3 30.5 0.96 7085
35 4.4 30.3 0.98 3603 4.3 31.1 0.96 6951
36 4.4 29.8 0.96 3704 4.5 31.6 0.98 7044
37 4.2 29.7 0.95 3536 4.2 31.2 0.95 6662
38 4.7 30.3 1.09 3881 4.2 31.3 0.98 6790
39 4.8 31.7 1.14 3817 4.1 31.2 0.98 6564
40 4.6 31.2 1.05 3667 4.5 31.7 1.02 7023
1 TO 13 WEEKS
----------------
MEAN 4.4 25.2 1.01 4424 4.2 24.6 0.97 8671
SD(D) 0.1 0.05 371 0.1 0.04 652
CV(E) 2.7 4.8 8.4 2.5 4.2 7.5
14 TO 52 WEEKS
----------------
MEAN 4.5 30.0 1.05 3736 4.2 29.6 0.99 7175
SD(D) 0.2 0.05 124 0.2 0.04 336
CV(E) 3.7 4.8 3.3 3.9 3.8 4.7
=============================================================================
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE
26 DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)
==================================================================================================================================
VEHICLE CONTROL 3125 PPM 6250 PPM 12500 PPM
---------------- --------------------------------- --------------------------------- ---------------------------------
DOSE/ DOSE/ DOSE/
GRAMS BODY GRAMS BODY CONTROL GRAMS BODY CONTROL GRAMS BODY CONTROL
FEED/ WEIGHT FEED/ WEIGHT FEED (B) DOSE/ FEED/ WEIGHT FEED (B) DOSE/ FEED/ WEIGHT FEED (B) DOSE/
WEEK DAY(A) (GRAMS) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C)
==================================================================================================================================
2 4.2 18.1 4.2 18.0 1.00 724 4.1 17.7 0.98 1432 4.1 17.4 0.98 2918
3 4.0 18.5 4.1 18.9 1.03 682 3.8 18.3 0.95 1285 3.8 17.8 0.95 2649
4 4.5 19.5 4.2 19.7 0.93 669 4.1 19.5 0.91 1306 4.0 18.8 0.89 2643
5 4.1 19.5 4.0 20.1 0.98 618 3.8 19.7 0.93 1206 3.9 19.7 0.95 2488
6 4.2 19.7 4.1 20.3 0.98 634 4.1 20.4 0.98 1269 4.1 19.3 0.98 2658
7 4.1 20.1 4.0 21.4 0.98 581 3.9 21.3 0.95 1155 4.1 20.7 1.00 2458
8 4.1 20.5 3.8 20.9 0.93 566 3.7 20.6 0.90 1118 4.0 20.6 0.98 2404
9 4.2 21.1 4.0 21.9 0.95 570 3.9 21.5 0.93 1134 4.1 21.3 0.98 2397
10 4.0 21.6 4.1 22.2 1.03 574 4.0 21.5 1.00 1156 4.1 21.9 1.03 2327
11 3.8 21.7 4.0 22.4 1.05 559 4.2 22.5 1.11 1165 4.0 21.9 1.05 2308
12 4.1 22.4 4.1 22.6 1.00 561 4.1 21.9 1.00 1166 4.1 21.9 1.00 2326
13 4.1 22.5 4.1 22.6 1.00 568 3.9 22.0 0.95 1117 4.2 22.3 1.02 2372
14 4.0 22.4 4.1 22.9 1.03 564 4.3 23.0 1.08 1158 4.1 22.5 1.03 2257
15 3.7 22.3 3.6 22.5 0.97 494 3.9 23.3 1.05 1057 4.1 22.4 1.11 2283
16 3.8 22.6 4.2 23.3 1.11 567 4.0 23.4 1.05 1056 4.0 22.5 1.05 2224
17 4.0 22.6 3.9 23.1 0.98 528 3.8 23.2 0.95 1027 4.1 22.5 1.03 2263
18 4.0 22.6 4.1 23.3 1.03 544 4.2 23.4 1.05 1112 4.1 22.9 1.03 2228
19 3.8 23.0 4.0 23.3 1.05 537 4.2 23.8 1.11 1110 4.1 23.4 1.08 2188
20 4.0 23.1 3.9 23.1 0.98 523 3.9 23.7 0.98 1024 3.8 23.0 0.95 2090
21 4.1 23.9 4.1 24.2 1.00 535 4.3 24.7 1.05 1084 3.9 23.3 0.95 2065
22 4.1 23.7 4.1 24.3 1.00 527 4.3 24.6 1.05 1088 3.9 22.9 0.95 2147
23 4.6 24.4 4.0 24.6 0.87 513 4.2 24.6 0.91 1068 4.1 23.1 0.89 2222
24 4.3 24.4 4.0 24.1 0.93 515 4.1 24.8 0.95 1044 3.8 23.1 0.88 2033
25 4.0 24.4 4.2 25.2 1.05 525 4.2 25.0 1.05 1037 4.0 24.0 1.00 2071
26 4.3 24.9 4.0 25.6 0.93 492 4.2 25.0 0.98 1053 4.4 23.9 1.02 2281
27 4.2 25.1 4.1 25.6 0.98 498 3.9 24.9 0.93 969 4.0 23.5 0.95 2126
28 4.0 25.3 3.8 25.2 0.95 475 4.3 25.1 1.08 1061 4.2 25.0 1.05 2107
29 4.2 25.3 3.9 25.4 0.93 479 3.8 24.9 0.90 955 3.8 24.9 0.90 1928
30 4.6 26.0 3.8 25.0 0.83 481 4.3 25.6 0.93 1039 4.5 25.4 0.98 2209
31 4.5 25.8 4.2 25.1 0.93 526 4.5 26.3 1.00 1065 4.3 25.1 0.96 2139
32 4.4 25.1 4.4 25.1 1.00 544 4.3 26.1 0.98 1036 4.6 25.3 1.05 2246
33 4.3 25.6 4.4 25.1 1.02 554 4.6 26.4 1.07 1091 4.4 25.0 1.02 2219
34 4.3 25.6 4.6 25.1 1.07 573 4.8 26.6 1.12 1132 4.5 25.4 1.05 2202
35 4.1 25.4 4.5 26.0 1.10 540 4.3 26.9 1.05 1007 4.4 26.1 1.07 2115
36 4.6 26.1 4.2 25.7 0.91 512 4.4 27.8 0.96 998 4.3 26.3 0.93 2026
37 4.4 25.9 3.8 25.4 0.86 472 4.3 27.6 0.98 982 4.3 25.8 0.98 2064
38 4.5 26.2 4.3 26.2 0.96 507 4.1 27.0 0.91 945 4.2 26.0 0.93 2000
39 4.3 26.5 4.0 26.4 0.93 474 4.1 27.6 0.95 932 4.3 26.4 1.00 2025
40 4.3 26.7 4.1 25.4 0.95 500 4.3 26.9 1.00 1000 4.4 26.5 1.02 2055
1 TO 13 WEEKS
----------------
MEAN 4.1 20.4 4.1 20.9 0.99 609 4.0 20.6 0.96 1209 4.0 20.3 0.98 2496
SD(D) 0.2 0.1 0.04 56 0.2 0.05 95 0.1 0.04 185
CV(E) 4.0 2.9 3.8 9.3 3.9 5.6 7.9 2.8 4.3 7.4
14 TO 52 WEEKS
----------------
MEAN 4.2 24.6 4.1 24.7 0.98 518 4.2 25.3 1.00 1042 4.2 24.3 0.99 2141
SD(D) 0.2 0.2 0.07 30 0.2 0.06 56 0.2 0.06 98
CV(E) 5.8 5.6 7.0 5.7 5.6 6.3 5.4 5.3 6.0 4.6
==================================================================================================================================
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE
26 DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)
=============================================================================
25000 PPM 50000 PPM
--------------------------------- ---------------------------------
DOSE/ DOSE/
GRAMS BODY CONTROL GRAMS BODY CONTROL
FEED/ WEIGHT FEED (B) DOSE/ FEED/ WEIGHT FEED (B) DOSE/
WEEK DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C)
=============================================================================
2 4.2 18.1 1.00 5774 3.9 17.8 0.93 10879
3 3.8 17.6 0.95 5388 3.8 17.9 0.95 10617
4 4.1 19.6 0.91 5255 4.0 19.6 0.89 10200
5 3.9 20.1 0.95 4804 3.8 20.3 0.93 9293
6 3.6 20.2 0.86 4408 3.8 20.2 0.90 9351
7 4.1 20.8 1.00 4911 3.8 21.3 0.93 9017
8 4.1 21.1 1.00 4848 3.6 20.7 0.88 8771
9 4.0 21.6 0.95 4578 4.0 21.8 0.95 9301
10 3.9 21.9 0.98 4461 3.9 22.4 0.98 8760
11 3.8 22.5 1.00 4271 3.8 22.7 1.00 8466
12 3.8 21.7 0.93 4424 3.9 23.2 0.95 8460
13 4.4 23.2 1.07 4737 4.0 23.1 0.98 8756
14 4.4 22.9 1.10 4768 4.1 23.1 1.03 8832
15 4.2 23.6 1.14 4495 3.8 23.5 1.03 8133
16 3.9 23.4 1.03 4183 4.2 24.5 1.11 8461
17 4.1 23.8 1.03 4262 3.9 24.4 0.98 7892
18 4.1 23.7 1.03 4273 3.9 24.5 0.98 8036
19 4.1 23.6 1.08 4320 4.2 24.9 1.11 8436
20 4.1 23.7 1.03 4302 4.0 25.9 1.00 7669
21 4.0 24.1 0.98 4152 3.9 26.0 0.95 7512
22 4.2 24.2 1.02 4328 3.8 25.7 0.93 7319
23 4.1 23.9 0.89 4301 4.1 25.7 0.89 7991
24 4.1 24.3 0.95 4212 4.3 26.1 1.00 8163
25 4.1 24.4 1.03 4190 3.9 26.2 0.98 7483
26 4.4 24.7 1.02 4439 3.8 26.1 0.88 7339
27 4.1 24.9 0.98 4145 3.8 26.3 0.90 7318
28 4.2 25.1 1.05 4151 3.9 27.3 0.98 7214
29 4.1 25.0 0.98 4140 3.9 27.5 0.93 7156
30 4.1 24.8 0.89 4119 3.9 27.2 0.85 7180
31 4.1 24.4 0.91 4220 4.2 27.9 0.93 7521
32 4.2 24.3 0.95 4370 4.1 28.0 0.93 7251
33 4.2 24.6 0.98 4282 4.3 27.8 1.00 7671
34 4.2 24.7 0.98 4243 4.1 27.9 0.95 7433
35 4.4 25.3 1.07 4292 4.1 27.7 1.00 7364
36 3.8 25.0 0.83 3827 3.9 27.8 0.85 7086
37 3.8 24.7 0.86 3866 4.1 27.2 0.93 7545
38 3.9 24.6 0.87 3959 4.2 28.1 0.93 7425
39 4.0 24.8 0.93 4042 4.0 28.0 0.93 7132
40 4.4 26.5 1.02 4195 4.2 28.3 0.98 7456
1 TO 13 WEEKS
----------------
MEAN 4.0 20.7 0.97 4822 3.9 20.9 0.94 9323
SD(D) 0.2 0.05 453 0.1 0.04 819
CV(E) 5.5 5.7 9.4 3.2 3.9 8.8
14 TO 52 WEEKS
----------------
MEAN 4.1 24.4 0.99 4225 4.0 26.4 0.96 7630
SD(D) 0.2 0.08 187 0.1 0.06 460
CV(E) 3.8 7.7 4.4 3.7 6.6 6.0
=============================================================================
(A) GRAMS OF FEED CONSUMED PER ANIMAL PER DAY.
(B) GRAMS OF FEED PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS.
(C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT.
(D) STANDARD DEVIATION OF WEEKLY MEAN.
(E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100.
DIAGNOSTIC TRAILER REPORT
FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE
26 DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)
==================================================================================================================================
VEHICLE CONTROL 3125 PPM 6250 PPM 12500 PPM 25000 PPM
---------------------- ---------------------- ---------------------- ---------------------- ----------------------
DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM
WEEK FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS
===================================================================================================================================
B 19.1 15 19.2 15 19.1 15 17.8 15 19.1 15
1 19.1 15 19.2 15 19.1 15 17.8 15 19.1 15
2 4.5 2490 21.5 15 4.2 2498 21.3 15 4.2 2505 20.1 15 4.3 2505 20.3 15 4.3 2505 21.7 15
3 4.1 2498 21.9 15 4.0 2490 22.0 15 4.4 2505 21.8 15 4.3 2505 21.2 15 4.4 2505 22.1 15
4 4.5 2520 22.6 15 4.5 2520 23.2 15 4.4 2505 22.7 15 4.3 2505 22.3 15 4.5 2505 23.3 15
5 4.5 2520 23.8 15 4.3 2520 23.7 15 4.5 2505 23.6 15 4.3 2505 23.1 15 4.4 2505 23.9 15
6 4.2 2550 24.6 15 4.1 2550 23.2 15 4.4 2550 24.6 15 4.2 2550 23.5 15 4.5 2550 25.0 15
7 4.5 2475 25.2 15 4.2 2475 24.8 15 4.4 2475 25.7 15 4.0 2490 23.9 15 4.4 2490 25.4 15
8 4.5 2520 26.0 15 4.2 2520 25.0 15 4.3 2520 25.8 15 4.2 2520 24.8 15 4.5 2520 25.9 15
9 4.4 2535 26.3 15 4.3 2535 25.9 15 4.4 2535 26.8 15 4.4 2535 25.6 15 4.3 2524 26.1 15
10 4.3 2505 27.4 15 4.3 2520 26.4 15 4.3 2520 26.7 15 4.3 2520 26.1 15 4.3 2475 26.4 15
11 4.3 2520 28.2 15 4.4 2505 26.7 15 4.5 2490 27.5 15 4.6 2478 26.8 15 4.5 2520 27.5 15
12 4.4 2352 28.5 14 4.1 2352 26.2 15 4.5 2352 28.0 14 4.3 2535 26.6 15 4.2 2531 26.7 15
13 4.3 2338 28.8 14 4.4 2340 27.4 15 4.5 2347 28.3 14 4.2 2505 27.0 15 4.7 2509 27.9 15
14 4.2 2358 29.0 14 4.2 2565 27.1 15 4.2 2380 27.8 14 4.2 2550 27.2 15 4.5 2520 28.1 15
15 4.2 2352 29.5 14 4.5 2505 28.5 15 4.5 2352 29.2 14 4.2 2520 28.0 15 4.4 2352 28.5 14
16 4.2 2352 29.5 14 4.1 2520 27.8 15 4.3 2352 28.8 14 4.3 2526 27.9 15 4.4 2352 28.4 14
17 4.2 2397 29.2 14 4.3 2505 27.9 15 4.3 2338 29.1 14 4.2 2505 28.3 15 4.5 2380 29.0 14
18 4.1 2352 29.5 14 4.4 2505 28.6 15 4.3 2338 29.2 14 4.3 2505 28.3 15 4.4 2352 28.8 14
19 4.1 2310 29.1 14 4.4 2535 29.4 15 4.4 2370 29.7 14 4.2 2550 28.2 15 4.5 2366 29.3 14
20 4.4 2352 29.7 14 4.1 2520 29.0 15 4.1 2184 29.9 13 4.2 2505 28.6 15 4.2 2338 29.9 14
21 4.3 2352 30.2 14 4.4 2535 29.6 15 4.5 2040 30.3 12 4.3 2535 29.0 15 4.2 2158 29.6 13
22 4.2 2338 30.4 14 4.2 2520 29.1 15 4.0 2004 29.7 12 4.3 2520 29.0 15 4.4 2182 29.4 13
23 4.3 2352 30.8 14 4.2 2520 29.1 15 4.5 1848 29.9 11 4.4 2520 29.2 15 4.5 2184 29.7 13
24 4.2 2353 30.7 14 4.2 2531 28.8 15 4.2 1848 30.1 11 4.3 2526 29.9 15 4.4 2184 30.0 13
25 4.4 2351 31.1 14 4.3 2520 29.1 15 4.3 1848 30.5 11 4.5 2505 30.0 15 4.5 2184 29.6 13
26 4.0 2352 30.8 14 4.3 2520 29.4 15 4.4 1848 30.7 11 4.2 2520 30.0 15 4.5 2184 30.3 13
27 4.3 2184 31.3 13 4.4 2520 29.4 15 4.2 1859 30.7 11 4.1 2535 29.7 15 4.5 2184 30.5 13
28 4.1 2184 31.5 13 4.3 2535 29.3 15 4.2 1826 30.5 11 4.2 2503 29.7 15 4.6 2184 30.7 13
29 4.2 2016 31.4 12 4.2 2535 28.8 15 4.0 1690 30.0 10 4.1 2535 30.1 15 4.5 2184 30.9 13
30 4.4 2016 31.8 12 4.6 2310 30.2 14 4.5 1677 30.0 10 4.4 2338 30.7 14 4.6 2184 31.1 13
31 4.5 2028 31.5 12 4.6 2352 30.4 14 4.7 1512 30.6 9 4.6 2171 30.5 13 4.8 2176 31.0 13
32 4.3 2019 31.1 12 4.6 2367 30.6 14 4.8 1521 30.9 9 4.4 2197 30.1 13 4.7 2184 31.3 13
33 4.4 2004 31.1 12 4.8 2350 30.6 14 4.7 1512 30.8 9 4.6 2184 30.0 13 4.5 2184 31.1 13
34 4.5 2028 31.3 12 4.7 2366 30.5 14 4.6 1521 31.2 9 4.8 2197 30.3 13 4.8 2197 30.8 13
35 4.5 2007 31.6 12 4.6 2338 30.6 14 4.6 1503 30.7 9 4.7 2009 30.8 13 4.4 2216 30.3 13
36 4.6 2016 32.0 12 4.6 2380 30.6 14 4.8 1512 31.7 9 4.8 2184 31.3 13 4.4 1980 29.8 12
37 4.4 2016 32.0 12 4.5 2324 30.1 14 4.7 1503 31.9 9 4.5 2171 30.9 13 4.2 2028 29.7 12
38 4.3 2016 31.7 12 4.7 2379 30.9 14 4.4 1530 31.6 9 4.3 2223 31.2 13 4.7 1845 30.3 12
39 4.2 2016 31.8 12 4.6 2353 31.1 14 4.6 1494 31.8 9 4.5 2158 31.3 13 4.8 1840 31.7 11
40 4.4 1512 32.8 9 4.3 1980 31.3 12 4.7 1328 32.1 8 4.5 1992 31.2 12 4.6 1848 31.2 11
MEAN BODY WGT FOR WEEKS
1 TO 13 24.9 24.2 24.7 23.8 24.7
14 TO 52 30.8 29.5 30.3 29.7 30.0
==================================================================================================================================
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
DIAGNOSTIC TRAILER REPORT
FEED AND COMPOUND CONSUMPTION BY MALE MICE IN THE
26 DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)
==============================
50000 PPM
----------------------
DAILY FEED BODY NUM
WEEK FEED HOURS WGT WGTS
===============================
B 18.6 15
1 18.6 15
2 4.1 2511 20.8 15
3 4.2 2505 22.0 15
4 4.3 2505 22.7 15
5 4.3 2493 23.6 15
6 4.1 2550 23.8 15
7 4.2 2490 24.9 15
8 4.1 2520 24.6 15
9 4.3 2520 25.5 15
10 4.3 2475 26.2 15
11 4.4 2520 26.8 15
12 4.3 2535 27.0 15
13 4.4 2505 27.4 15
14 4.4 2535 27.6 15
15 4.2 2520 28.1 15
16 4.1 2520 27.8 15
17 4.2 2550 28.6 15
18 4.2 2520 28.6 15
19 4.3 2535 28.4 15
20 4.1 2505 28.9 15
21 4.2 2324 29.4 14
22 3.9 2352 28.5 14
23 4.2 2352 28.4 14
24 4.4 2356 27.9 14
25 4.0 2352 28.0 14
26 4.0 2352 27.2 14
27 4.1 2016 29.0 12
28 4.2 2016 29.7 12
29 4.1 2016 30.0 12
30 4.3 1848 30.9 11
31 4.6 1848 30.9 11
32 4.3 1859 31.0 11
33 4.5 1848 31.2 11
34 4.3 1859 30.5 11
35 4.3 1881 31.1 11
36 4.5 1815 31.6 11
37 4.2 1848 31.2 11
38 4.2 1853 31.3 11
39 4.1 1837 31.2 11
40 4.5 1670 31.7 10
MEAN BODY WGT FOR WEEKS
1 TO 13 24.1
14 TO 52 29.6
==============================
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
DIAGNOSTIC TRAILER REPORT
FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE
26 DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)
==================================================================================================================================
VEHICLE CONTROL 3125 PPM 6250 PPM 12500 PPM 25000 PPM
---------------------- ---------------------- ---------------------- ---------------------- ----------------------
DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM DAILY FEED BODY NUM
WEEK FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS FEED HOURS WGT WGTS
===================================================================================================================================
B 16.6 15 16.6 15 15.8 15 15.5 15 16.4 15
1 16.6 15 16.6 15 15.8 15 15.5 15 16.4 15
2 4.2 2490 18.1 15 4.2 2505 18.0 15 4.1 2505 17.7 15 4.1 2505 17.4 15 4.2 2507 18.1 15
3 4.0 2490 18.5 15 4.1 2490 18.9 15 3.8 2505 18.3 15 3.8 2505 17.8 15 3.8 2504 17.6 15
4 4.5 2520 19.5 15 4.2 2520 19.7 15 4.1 2505 19.5 15 4.0 2505 18.8 15 4.1 2505 19.6 15
5 4.1 2520 19.5 15 4.0 2520 20.1 15 3.8 2505 19.7 15 3.9 2505 19.7 15 3.9 2338 20.1 14
6 4.2 2550 19.7 15 4.1 2550 20.3 15 4.1 2550 20.4 15 4.1 2550 19.3 15 3.6 2210 20.2 14
7 4.1 2475 20.1 15 4.0 2475 21.4 15 3.9 2490 21.3 15 4.1 2490 20.7 15 4.1 2324 20.8 14
8 4.1 2520 20.5 15 3.8 2520 20.9 15 3.7 2520 20.6 15 4.0 2520 20.6 15 4.1 2352 21.1 14
9 4.2 2535 21.1 15 4.0 2535 21.9 15 3.9 2535 21.5 15 4.1 2535 21.3 15 4.0 2352 21.6 14
10 4.0 2505 21.6 15 4.1 2520 22.2 15 4.0 2352 21.5 14 4.1 2520 21.9 15 3.9 2310 21.9 14
11 3.8 2520 21.7 15 4.0 2491 22.4 15 4.2 2158 22.5 13 4.0 2475 21.9 15 3.8 2352 22.5 14
12 4.1 2520 22.4 15 4.1 2520 22.6 15 4.1 2187 21.9 13 4.1 2533 21.9 15 3.8 2366 21.7 14
13 4.1 2505 22.5 15 4.1 2349 22.6 14 3.9 2181 22.0 13 4.2 2507 22.3 15 4.4 2338 23.2 14
14 4.0 2535 22.4 15 4.1 2394 22.9 14 4.3 2210 23.0 13 4.1 2550 22.5 15 4.4 2356 22.9 14
15 3.7 2520 22.3 15 3.6 2338 22.5 14 3.9 2184 23.3 13 4.1 2352 22.4 14 4.2 2352 23.6 14
16 3.8 2520 22.6 15 4.2 2352 23.3 14 4.0 2184 23.4 13 4.0 2366 22.5 14 3.9 2352 23.4 14
17 4.0 2404 22.6 14 3.9 2338 23.1 14 3.8 2004 23.2 12 4.1 2338 22.5 14 4.1 2380 23.8 14
18 4.0 2352 22.6 14 4.1 2338 23.3 14 4.2 2004 23.4 12 4.1 2338 22.9 14 4.1 2352 23.7 14
19 3.8 2310 23.0 14 4.0 2366 23.3 14 4.2 2028 23.8 12 4.1 2380 23.4 14 4.1 2366 23.6 14
20 4.0 2352 23.1 14 3.9 2352 23.1 14 3.9 2016 23.7 12 3.8 2171 23.0 13 4.1 2338 23.7 14
21 4.1 2352 23.9 14 4.1 2366 24.2 14 4.3 2040 24.7 12 3.9 2197 23.3 13 4.0 2324 24.1 14
22 4.1 2338 23.7 14 4.1 2352 24.3 14 4.3 1837 24.6 11 3.9 2184 22.9 13 4.2 2352 24.2 14
23 4.6 2352 24.4 14 4.0 2352 24.6 14 4.2 1848 24.6 11 4.1 2184 23.1 13 4.1 2352 23.9 14
24 4.3 2352 24.4 14 4.0 2366 24.1 14 4.1 1848 24.8 11 3.8 2184 23.1 13 4.1 2352 24.3 14
25 4.0 2352 24.4 14 4.2 2352 25.2 14 4.2 1848 25.0 11 4.0 1837 24.0 11 4.1 2352 24.4 14
26 4.3 2352 24.9 14 4.0 2352 25.6 14 4.2 1848 25.0 11 4.4 1848 23.9 11 4.4 2352 24.7 14
27 4.2 2352 25.1 14 4.1 2357 25.6 14 3.9 1859 24.9 11 4.0 1859 23.5 11 4.1 2352 24.9 14
28 4.0 2352 25.3 14 3.8 2364 25.2 14 4.3 1826 25.1 11 4.2 1660 25.0 10 4.2 2352 25.1 14
29 4.2 2352 25.3 14 3.9 2197 25.4 13 3.8 1859 24.9 11 3.8 1690 24.9 10 4.1 2352 25.0 14
30 4.6 2184 26.0 13 3.8 1980 25.0 12 4.3 1680 25.6 10 4.5 1670 25.4 10 4.1 2352 24.8 14
31 4.5 2197 25.8 13 4.2 1848 25.1 11 4.5 1511 26.3 9 4.3 1670 25.1 10 4.1 2341 24.4 14
32 4.4 2197 25.1 13 4.4 1859 25.1 11 4.3 1521 26.1 9 4.6 1690 25.3 10 4.2 2350 24.3 14
33 4.3 2171 25.6 13 4.4 1848 25.1 11 4.6 1512 26.4 9 4.4 1680 25.0 10 4.2 2352 24.6 14
34 4.3 2197 25.6 13 4.6 1859 25.1 11 4.8 1521 26.6 9 4.5 1690 25.4 10 4.2 2366 24.7 14
35 4.1 2184 25.4 13 4.5 1837 26.0 11 4.3 1503 26.9 9 4.4 1680 26.1 10 4.4 2394 25.3 14
36 4.6 2016 26.1 12 4.2 1870 25.7 11 4.4 1512 27.8 9 4.3 1680 26.3 10 3.8 2310 25.0 14
37 4.4 2032 25.9 12 3.8 1670 25.4 11 4.3 1512 27.6 9 4.3 1680 25.8 10 3.8 2380 24.7 14
38 4.5 1992 26.2 12 4.3 1859 26.2 11 4.1 1521 27.0 9 4.2 1690 26.0 10 3.9 2338 24.6 14
39 4.3 2016 26.5 12 4.0 1848 26.4 11 4.1 1494 27.6 9 4.3 1660 26.4 10 4.0 2338 24.8 14
40 4.3 1864 26.7 11 4.1 1670 25.4 10 4.3 1512 26.9 9 4.4 1512 26.5 9 4.4 1870 26.5 11
MEAN BODY WGT FOR WEEKS
1 TO 13 20.1 20.6 20.2 19.9 20.4
14 TO 52 24.6 24.7 25.3 24.3 24.4
==================================================================================================================================
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
DIAGNOSTIC TRAILER REPORT
FEED AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE
26 DOSED FEED STUDY OF TRANSGENIC MODEL EVALUATION II (ASPARTAME)
==============================
50000 PPM
----------------------
DAILY FEED BODY NUM
WEEK FEED HOURS WGT WGTS
===============================
B 16.6 15
1 16.6 15
2 3.9 2520 17.8 15
3 3.8 2505 17.9 15
4 4.0 2505 19.6 15
5 3.8 2490 20.3 15
6 3.8 2550 20.2 15
7 3.8 2490 21.3 15
8 3.6 2520 20.7 15
9 4.0 2520 21.8 15
10 3.9 2475 22.4 15
11 3.8 2516 22.7 15
12 3.9 2535 23.2 15
13 4.0 2338 23.1 14
14 4.1 2028 23.1 12
15 3.8 2016 23.5 12
16 4.2 2016 24.5 12
17 3.9 2040 24.4 12
18 3.9 2016 24.5 12
19 4.2 2028 24.9 12
20 4.0 2004 25.9 12
21 3.9 1992 26.0 12
22 3.8 2016 25.7 12
23 4.1 1848 25.7 11
24 4.3 1849 26.1 11
25 3.9 1848 26.2 11
26 3.8 1848 26.1 11
27 3.8 1848 26.3 11
28 3.9 1677 27.3 10
29 3.9 1680 27.5 10
30 3.9 1680 27.2 10
31 4.2 1680 27.9 10
32 4.1 1521 28.0 9
33 4.3 1512 27.8 9
34 4.1 1521 27.9 9
35 4.1 1539 27.7 9
36 3.9 1485 27.8 9
37 4.1 1530 27.2 9
38 4.2 1503 28.1 9
39 4.0 1503 28.0 9
40 4.2 1352 28.3 8
MEAN BODY WGT FOR WEEKS
1 TO 13 20.6
14 TO 52 26.4
==============================
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.