TDMS Study 99033-03 Pathology Tables
NTP EXP/TEST: 99033-03 TRANSGENIC MODEL EVALUATION II (ASPARTAME) PAGE: 1
TEST TYPE: SUBCHRON 26-WEEK INITIAL AND CURRENT BODY WEIGHT DATE: 03/05/03
ROUTE: DOSED FEED TIME: 13:38:57
EIS REPORT 03
FINAL #3 TG:P16 MICE
FACILITY: BIORELIANCE
NTP C#: 99033B
CONTRACT NUMBER: N01-ES-65406
CAS NUMBER: 22839-47-0
ANIMAL SUPPLIER: TACONIC FARMS
CAGE RANGE: ALL
DATE RANGE: ALL
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP EXP/TEST: 99033-03 TRANSGENIC MODEL EVALUATION II (ASPARTAME) PAGE: 2
TEST TYPE: SUBCHRON 26-WEEK INITIAL AND CURRENT BODY WEIGHT DATE: 03/05/03
ROUTE: DOSED FEED EISRPT03 TIME: 13:38:57
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SPECIES-STRAIN: TG:P16-INK4A-MICE SEX: FEMALE WEEK ON DOSE: 40 FIRST DOSE: 10/27/99
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-----INITIAL----- ------------CURRENT------------- -----CHANGE------
TREATMENT N MEAN(G) SD N MEAN(G) SD % REL CNTRL N MEAN(G) SD
VEHICLE CONTROL 15 17.9 1.6 13 27.4 3.3 13 9.5 2.5
3125 PPM 15 18.4 1.5 15 27.9 3.0 101.8 15 9.6 2.4
6250 PPM 15 18.3 1.5 13 28.8 3.5 105.1 13 10.7 3.3
12500 PPM 15 18.2 1.1 15 28.6 4.4 104.3 15 10.4 3.9
25000 PPM 15 17.9 1.5 15 26.9 2.9 98.1 15 9.1 2.2
50000 PPM 15 18.2 1.4 14 28.3 3.3 103.2 14 10.3 3.0
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SPECIES-STRAIN: TG:P16-INK4A-MICE SEX: MALE WEEK ON DOSE: 40 FIRST DOSE: 10/27/99
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-----INITIAL----- ------------CURRENT------------- -----CHANGE------
TREATMENT N MEAN(G) SD N MEAN(G) SD % REL CNTRL N MEAN(G) SD
VEHICLE CONTROL 15 22.2 1.7 14 35.7 3.9 14 13.2 3.0
3125 PPM 15 22.1 1.4 14 33.1 2.6 92.7 14 11.2 2.5
6250 PPM 15 22.2 1.3 15 33.7 3.5 94.3 15 11.5 2.8
12500 PPM 15 22.0 1.3 14 35.0 4.4 98.0 14 13.0 3.3
25000 PPM 15 21.8 1.6 14 35.6 3.4 99.7 14 13.6 2.5
50000 PPM 15 21.9 1.7 15 34.2 4.3 95.7 15 12.3 3.5
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