TDMS Study 99033-03 Pathology Tables
NTP Experiment-Test: 99033-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SPECIAL STUDY TRANSGENIC MODEL EVALUATION II(ASPARTAME) Date: 06/05/02
Route: DOSED FEED Time: 11:51:20
FINAL/MICE
Facility: BIORELIANCE
Chemical CAS #: 22839-47-0
Lock Date: 07/20/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 99033-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SPECIAL STUDY TRANSGENIC MODEL EVALUATION II(ASPARTAME) Date: 06/05/02
Route: DOSED FEED Time: 11:51:20
____________________________________________________________________________________________________________________________________
MICE:P16(INK4A)/(+/-) (C57BL/6) FEMALE VEHICLE 3125 PPM 6250 PPM 12500 25000 50000
CONTROL PPM PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 15 15 15 15 15 15
Early Deaths
Natural Death 2 2
Moribund Sacrifice 1
Survivors
Terminal Sacrifice 13 15 13 15 15 14
Animals Examined Microscopically 15 15 15 15 15 15
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ALIMENTARY SYSTEM
Gallbladder (12) (1) (14)
Histiocytic Sarcoma 1 (100%)
Intestine Large, Cecum (14) (1) (15)
Leiomyoma 1 (100%)
Liver (15) (15) (15) (15) (15) (15)
Histiocytic Sarcoma 2 (13%) 1 (7%) 1 (7%) 2 (13%)
Leukemia Erythrocytic 1 (7%)
Pancreas (14) (1) (15)
Histiocytic Sarcoma 1 (100%) 1 (7%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (15) (15) (15) (15) (15) (15)
Hemangiosarcoma 1 (7%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Pituitary Gland (10) (13) (13) (12) (11) (12)
Adenoma 1 (8%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
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NTP Experiment-Test: 99033-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SPECIAL STUDY TRANSGENIC MODEL EVALUATION II(ASPARTAME) Date: 06/05/02
Route: DOSED FEED Time: 11:51:20
____________________________________________________________________________________________________________________________________
MICE:P16(INK4A)/(+/-) (C57BL/6) FEMALE VEHICLE 3125 PPM 6250 PPM 12500 25000 50000
CONTROL PPM PPM PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (14) (15) (15) (15) (15) (15)
Histiocytic Sarcoma 2 (14%) 1 (7%) 2 (13%)
Uterus (14) (15) (15) (15) (15) (15)
Histiocytic Sarcoma 1 (7%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (14) (15)
Histiocytic Sarcoma 4 (29%) 3 (20%)
Lymph Node, Mandibular (14) (15) (13) (15) (15) (15)
Histiocytic Sarcoma 1 (7%)
Lymph Node, Mesenteric (14) (15) (14) (15) (15) (14)
Histiocytic Sarcoma 1 (7%)
Lymph Node, Mediastinal (14) (15) (12) (13) (12) (12)
Histiocytic Sarcoma 1 (7%)
Spleen (14) (15) (14) (15) (15) (15)
Hemangiosarcoma 1 (7%)
Histiocytic Sarcoma 1 (7%) 2 (13%)
Leukemia Erythrocytic 1 (7%)
Thymus (14) (15) (14) (14) (15) (15)
Histiocytic Sarcoma 1 (7%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (13) (15) (15) (15) (15) (15)
Hemangiosarcoma 1 (7%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (14) (14) (14) (15) (15) (15)
Meninges, Histiocytic Sarcoma 1 (7%)
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 99033-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SPECIAL STUDY TRANSGENIC MODEL EVALUATION II(ASPARTAME) Date: 06/05/02
Route: DOSED FEED Time: 11:51:20
____________________________________________________________________________________________________________________________________
MICE:P16(INK4A)/(+/-) (C57BL/6) FEMALE VEHICLE 3125 PPM 6250 PPM 12500 25000 50000
CONTROL PPM PPM PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (14) (14) (14) (15) (15) (15)
Alveolar/Bronchiolar Adenoma 1 (7%)
Alveolar/Bronchiolar Carcinoma 1 (7%)
Histiocytic Sarcoma 1 (7%) 1 (7%) 2 (13%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (14) (15)
Adenoma 1 (7%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(15) *(15) *(15) *(15) *(15) *(15)
Histiocytic Sarcoma 5 (33%) 1 (7%) 1 (7%) 3 (20%)
Leukemia Erythrocytic 1 (7%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 4
NTP Experiment-Test: 99033-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SPECIAL STUDY TRANSGENIC MODEL EVALUATION II(ASPARTAME) Date: 06/05/02
Route: DOSED FEED Time: 11:51:20
____________________________________________________________________________________________________________________________________
MICE:P16(INK4A)/(+/-) (C57BL/6) FEMALE VEHICLE 3125 PPM 6250 PPM 12500 25000 50000
CONTROL PPM PPM PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 6 2 4 1 6
Total Primary Neoplasms 6 2 4 1 6
Total Animals with Benign Neoplasms 1 1 1 1
Total Benign Neoplasms 1 1 1 1
Total Animals with Malignant Neoplasms 5 1 3 1 5
Total Malignant Neoplasms 5 1 3 1 5
Total Animals with Metastatic Neoplasms
Total Metastatic Neoplasm
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 5
NTP Experiment-Test: 99033-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SPECIAL STUDY TRANSGENIC MODEL EVALUATION II(ASPARTAME) Date: 06/05/02
Route: DOSED FEED Time: 11:51:20
____________________________________________________________________________________________________________________________________
MICE:P16(INK4A)/(+/-) (C57BL/6) MALE VEHICLE 3125 PPM 6250 PPM 12500 25000 50000
CONTROL PPM PPM PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 15 15 15 15 15 15
Early Deaths
Natural Death 1 1 1 1
Survivors
Terminal Sacrifice 14 14 15 14 14 15
Animals Examined Microscopically 15 15 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (15) (15) (15) (14) (15) (15)
Histiocytic Sarcoma 1 (7%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (15) (15) (15) (15) (15) (15)
Histiocytic Sarcoma 1 (7%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
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NTP Experiment-Test: 99033-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SPECIAL STUDY TRANSGENIC MODEL EVALUATION II(ASPARTAME) Date: 06/05/02
Route: DOSED FEED Time: 11:51:20
____________________________________________________________________________________________________________________________________
MICE:P16(INK4A)/(+/-) (C57BL/6) MALE VEHICLE 3125 PPM 6250 PPM 12500 25000 50000
CONTROL PPM PPM PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (14) (15)
Histiocytic Sarcoma 2 (14%)
Lymph Node, Mandibular (15) (15) (15) (14) (14) (15)
Histiocytic Sarcoma 1 (7%)
Lymph Node, Mesenteric (15) (15) (15) (14) (14) (15)
Histiocytic Sarcoma 1 (7%)
Spleen (15) (15) (15) (14) (15) (15)
Hemangiosarcoma 1 (7%)
Histiocytic Sarcoma 1 (7%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15) (15) (15)
Alveolar/Bronchiolar Adenoma 1 (7%) 1 (7%)
Histiocytic Sarcoma 1 (7%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 7
NTP Experiment-Test: 99033-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SPECIAL STUDY TRANSGENIC MODEL EVALUATION II(ASPARTAME) Date: 06/05/02
Route: DOSED FEED Time: 11:51:20
____________________________________________________________________________________________________________________________________
MICE:P16(INK4A)/(+/-) (C57BL/6) MALE VEHICLE 3125 PPM 6250 PPM 12500 25000 50000
CONTROL PPM PPM PPM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (14) (15) (15)
Histiocytic Sarcoma 1 (7%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(15) *(15) *(15) *(15) *(15) *(15)
Histiocytic Sarcoma 2 (13%) 1 (7%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 8
NTP Experiment-Test: 99033-03 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SPECIAL STUDY TRANSGENIC MODEL EVALUATION II(ASPARTAME) Date: 06/05/02
Route: DOSED FEED Time: 11:51:20
____________________________________________________________________________________________________________________________________
MICE:P16(INK4A)/(+/-) (C57BL/6) MALE VEHICLE 3125 PPM 6250 PPM 12500 25000 50000
CONTROL PPM PPM PPM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 2 2 1 1
Total Primary Neoplasms 2 2 1 1
Total Animals with Benign Neoplasms 1 1
Total Benign Neoplasms 1 1
Total Animals with Malignant Neoplasms 2 2
Total Malignant Neoplasms 2 2
Total Animals with Metastatic Neoplasms
Total Metastatic Neoplasm
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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