TDMS Study 99039-02 Pathology Tables
NTP Experiment-Test: 99039-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SPECIAL STUDY TRANSGENIC MODEL EVALUATION II(ACESULFAME POTASSIUM) Date: 03/21/02
Route: DOSED FEED Time: 13:33:14
final#1/Mice
Facility: BIORELIANCE
Chemical CAS #: 55589-62-3
Lock Date: 07/20/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 99039-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SPECIAL STUDY TRANSGENIC MODEL EVALUATION II(ACESULFAME POTASSIUM) Date: 03/21/02
Route: DOSED FEED Time: 13:33:14
____________________________________________________________________________________________________________________________________
MICE:P53+/-(C57BL/6) FEMALE VEHICLE 0.3 % 1.0 % 3.0 %
CONTROL
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DISPOSITION SUMMARY
Animals Initially in Study 15 15 15 15
Early Deaths
Moribund Sacrifice 1 1
Natural Death 1 1
Survivors
Terminal Sacrifice 11 14 14 13
Accidently Killed 3 1
Animals Examined Microscopically 15 1 2 15
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ALIMENTARY SYSTEM
Mesentery (1)
Sarcoma 1 (100%)
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CARDIOVASCULAR SYSTEM
Heart (15) (15)
Lymphoma Malignant 1 (7%)
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ENDOCRINE SYSTEM
None
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GENERAL BODY SYSTEM
Tissue NOS (1)
Pelvic, Osteosarcoma, Metastatic, Bone 1 (100%)
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GENITAL SYSTEM
None
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NTP Experiment-Test: 99039-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SPECIAL STUDY TRANSGENIC MODEL EVALUATION II(ACESULFAME POTASSIUM) Date: 03/21/02
Route: DOSED FEED Time: 13:33:14
____________________________________________________________________________________________________________________________________
MICE:P53+/-(C57BL/6) FEMALE VEHICLE 0.3 % 1.0 % 3.0 %
CONTROL
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (1)
Pancreatic, Histiocytic Sarcoma 1 (100%)
Spleen (15) (14)
Histiocytic Sarcoma 1 (7%)
Thymus (15) (14)
Histiocytic Sarcoma 1 (7%)
Lymphoma Malignant 1 (7%)
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INTEGUMENTARY SYSTEM
Mammary Gland (15) (1) (13)
Osteosarcoma 1 (100%)
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MUSCULOSKELETAL SYSTEM
Bone (15) (14)
Femur, Osteosarcoma 1 (7%)
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NERVOUS SYSTEM
None
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RESPIRATORY SYSTEM
Lung (15) (15)
Lymphoma Malignant 1 (7%)
Osteosarcoma, Metastatic, Bone 1 (7%)
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SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 3
NTP Experiment-Test: 99039-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SPECIAL STUDY TRANSGENIC MODEL EVALUATION II(ACESULFAME POTASSIUM) Date: 03/21/02
Route: DOSED FEED Time: 13:33:14
____________________________________________________________________________________________________________________________________
MICE:P53+/-(C57BL/6) FEMALE VEHICLE 0.3 % 1.0 % 3.0 %
CONTROL
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(15) *(1) *(2) *(15)
Histiocytic Sarcoma 1 (7%)
Lymphoma Malignant 1 (7%)
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* Number of animals with any tissue examined microscopically
Page 4
NTP Experiment-Test: 99039-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SPECIAL STUDY TRANSGENIC MODEL EVALUATION II(ACESULFAME POTASSIUM) Date: 03/21/02
Route: DOSED FEED Time: 13:33:14
____________________________________________________________________________________________________________________________________
MICE:P53+/-(C57BL/6) FEMALE VEHICLE 0.3 % 1.0 % 3.0 %
CONTROL
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 1 1 1 2
Total Primary Neoplasms 1 1 1 2
Total Animals with Benign Neoplasms
Total Benign Neoplasms
Total Animals with Malignant Neoplasms 1 1 1 2
Total Malignant Neoplasms 1 1 1 2
Total Animals with Metastatic Neoplasms 1
Total Metastatic Neoplasm 2
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 5
NTP Experiment-Test: 99039-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SPECIAL STUDY TRANSGENIC MODEL EVALUATION II(ACESULFAME POTASSIUM) Date: 03/21/02
Route: DOSED FEED Time: 13:33:14
____________________________________________________________________________________________________________________________________
MICE:P53+/-(C57BL/6) MALE VEHICLE 0.3 % 1.0 % 3.0 %
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 15 15 15 15
Early Deaths
Moribund Sacrifice 1 1
Survivors
Accidently Killed 3 1
Terminal Sacrifice 11 15 14 14
Animals Examined Microscopically 15 1 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
None
____________________________________________________________________________________________________________________________________
Page 6
NTP Experiment-Test: 99039-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SPECIAL STUDY TRANSGENIC MODEL EVALUATION II(ACESULFAME POTASSIUM) Date: 03/21/02
Route: DOSED FEED Time: 13:33:14
____________________________________________________________________________________________________________________________________
MICE:P53+/-(C57BL/6) MALE VEHICLE 0.3 % 1.0 % 3.0 %
CONTROL
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (15) (1) (15)
Pinna, Hemangiosarcoma 1 (100%)
Subcutaneous Tissue, Fibrosarcoma 1 (7%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
Page 7
NTP Experiment-Test: 99039-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: SPECIAL STUDY TRANSGENIC MODEL EVALUATION II(ACESULFAME POTASSIUM) Date: 03/21/02
Route: DOSED FEED Time: 13:33:14
____________________________________________________________________________________________________________________________________
MICE:P53+/-(C57BL/6) MALE VEHICLE 0.3 % 1.0 % 3.0 %
CONTROL
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 1 1
Total Primary Neoplasms 1 1
Total Animals with Benign Neoplasms
Total Benign Neoplasms
Total Animals with Malignant Neoplasms 1 1
Total Malignant Neoplasms 1 1
Total Animals with Metastatic Neoplasms
Total Metastatic Neoplasm
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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