TDMS Study 99039-02 Pathology Tables
NTP Experiment-Test: 99039-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: 26-39 WEEKS WITH AVERAGE SEVERITY GRADES[b] Date: 02/21/03
Route: DOSED FEED TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Time: 10:33:21
FINAL#3/P53 +/- MICE
Facility: BIORELIANCE
Chemical CAS #: 55589-62-3
Lock Date: 07/20/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 1
NTP Experiment-Test: 99039-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: 26-39 WEEKS WITH AVERAGE SEVERITY GRADES[b] Date: 02/21/03
Route: DOSED FEED TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Time: 10:33:21
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) FEMALE VEHICLE 0.3 % 1.0 % 3.0 %
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15
Early Deaths
Moribund Sacrifice 1 1
Natural Death 1 1
Survivors
Terminal Sacrifice 11 14 14 13
Accidently Killed 3 1
Animals Examined Microscopically 15 1 2 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (15) (14)
Infiltration Cellular, Focal, Lymphocyte 2 [1.0] 1 [1.0]
Inflammation, Chronic Active 6 [1.2] 7 [1.0]
Hepatocyte, Necrosis, Focal 1 [1.0]
Salivary Glands (15) (14)
Infiltration Cellular, Focal, Lymphocyte 10 [1.1] 9 [1.3]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (14)
Hyperplasia, Focal 2 [1.0] 2 [1.5]
Subcapsular, Hyperplasia, Focal 13 [1.2] 12 [1.1]
Thyroid Gland (15) (14)
Ectopic Thymus 1 [1.0]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 2
NTP Experiment-Test: 99039-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: 26-39 WEEKS WITH AVERAGE SEVERITY GRADES[b] Date: 02/21/03
Route: DOSED FEED TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Time: 10:33:21
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) FEMALE VEHICLE 0.3 % 1.0 % 3.0 %
CONTROL
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Uterus (15) (1) (14)
Endometrium, Hyperplasia, Cystic 13 [1.8] 1 [4.0] 13 [1.3]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (15) (14)
Hyperplasia 1 [2.0]
Spleen (15) (14)
Hematopoietic Cell Proliferation 2 [2.0] 1 [1.0]
Thymus (15) (14)
Atrophy 6 [1.0] 2 [1.0]
Atrophy, Diffuse 1 [4.0]
Atrophy, Focal 4 [1.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (15) (1) (13)
Inflammation, Acute 1 [2.0]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15)
Infiltration Cellular, Lymphocyte 1 [1.0] 1 [2.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (15) (14)
Inflammation, Chronic Active 1 [1.0]
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 3
NTP Experiment-Test: 99039-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: 26-39 WEEKS WITH AVERAGE SEVERITY GRADES[b] Date: 02/21/03
Route: DOSED FEED TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Time: 10:33:21
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) FEMALE VEHICLE 0.3 % 1.0 % 3.0 %
CONTROL
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (14)
Inflammation, Chronic Active 1 [2.0]
Renal Tubule, Dilatation, Focal 6 [1.0] 2 [1.0]
Renal Tubule, Nephropathy 1 [1.0]
Urinary Bladder (14) (14)
Infiltration Cellular, Focal, Lymphocyte 1 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 4
NTP Experiment-Test: 99039-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: 26-39 WEEKS WITH AVERAGE SEVERITY GRADES[b] Date: 02/21/03
Route: DOSED FEED TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Time: 10:33:21
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) MALE VEHICLE 0.3 % 1.0 % 3.0 %
CONTROL
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15
Early Deaths
Moribund Sacrifice 1 1
Survivors
Accidently Killed 3 1
Terminal Sacrifice 11 15 14 14
Animals Examined Microscopically 15 1 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (15) (15)
Inflammation, Chronic Active 1 [1.0] 5 [1.0]
Hepatocyte, Inflammation, Chronic Active 1 [1.0]
Hepatocyte, Necrosis, Focal 1 [1.0]
Hepatocyte, Centrilobular, Hypertrophy 1 [1.0]
Mesentery (1) (1)
Fat, Inflammation, Chronic Active, Focal 1 [2.0]
Fat, Necrosis, Focal 1 [4.0]
Salivary Glands (15) (15)
Infiltration Cellular, Focal, Lymphocyte 10 [1.1] 8 [1.1]
Tongue (15) (15)
Inflammation 1 [2.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15)
Hypertrophy, Focal 1 [2.0]
Capsule, Inflammation, Chronic Active,
Diffuse 1 [2.0]
Subcapsular, Hyperplasia, Focal 1 [1.0] 1 [1.0]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 5
NTP Experiment-Test: 99039-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: 26-39 WEEKS WITH AVERAGE SEVERITY GRADES[b] Date: 02/21/03
Route: DOSED FEED TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Time: 10:33:21
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) MALE VEHICLE 0.3 % 1.0 % 3.0 %
CONTROL
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (15) (15)
Infiltration Cellular, Lymphocyte 1 [2.0]
Polyarteritis 1 [2.0]
Epithelium, Degeneration, Focal 1 [2.0]
Testes (15) (15)
Mineralization, Focal 1 [1.0]
Sertoli Cell, Germinal Epithelium,
Degeneration, Focal 1 [2.0]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (1)
Inguinal, Hyperplasia 1 [2.0]
Lymph Node, Mandibular (15) (15)
Hyperplasia 2 [2.0]
Lymph Node, Mediastinal (1)
Edema 1 [2.0]
Inflammation, Chronic Active, Diffuse 1 [3.0]
Spleen (15) (15)
Hematopoietic Cell Proliferation 1 [2.0] 1 [1.0]
Thymus (15) (14)
Atrophy 2 [1.0] 2 [1.0]
Atrophy, Focal 1 [1.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (15) (1) (15)
Subcutaneous Tissue, Inflammation, Chronic
Active, Focal 1 [1.0]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 6
NTP Experiment-Test: 99039-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: 26-39 WEEKS WITH AVERAGE SEVERITY GRADES[b] Date: 02/21/03
Route: DOSED FEED TRANSGENIC MODEL EVALUATION II (ACESULFAME POTASSIUM) Time: 10:33:21
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) MALE VEHICLE 0.3 % 1.0 % 3.0 %
CONTROL
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (15) (15)
Inflammation, Chronic Active 1 [2.0]
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15)
Alveolar Epithelium, Inflammation, Chronic
Active, Focal 1 [1.0] 1 [1.0]
Nose (15) (15)
Inflammation, Chronic Active 1 [2.0]
Inflammation, Granulomatous 1 [2.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (15) (15)
Infiltration Cellular, Lymphocyte 1 [1.0]
Inflammation, Chronic Active 4 [1.3] 2 [1.0]
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15)
Inflammation, Chronic Active 1 [2.0]
Renal Tubule, Dilatation, Focal 1 [2.0] 2 [1.0]
Renal Tubule, Nephropathy 1 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 7
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