TDMS Study 97013-92 Pathology Tables
NTP Experiment-Test: 97013-92 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03
Route: SKIN APPLICATION Time: 14:28:00
FINAL#1 MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 7789-38-0
Lock Date: 07/30/01
Cage Range: All
Reasons For Removal: 25019 Moribund Sacrifice 25020 Natural Death
25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 97013-92 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03
Route: SKIN APPLICATION Time: 14:28:00
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 64 MG/KG 128 256
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10
Early Deaths
Moribund Sacrifice 1 1 2 1
Natural Death 1 2 1
Survivors
Terminal Sacrifice 7 7 8 8
Animals Examined Microscopically 9 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (9) (10) (10) (10)
Hematopoietic Cell Proliferation 2 (22%) 2 (20%) 2 (20%) 2 (20%)
Inflammation, Chronic Active 7 (78%) 9 (90%) 10 (100%) 9 (90%)
Necrosis 2 (22%) 1 (10%) 1 (10%) 2 (20%)
Hepatocyte, Fatty Change 1 (11%)
Hepatocyte, Vacuolization Cytoplasmic 7 (78%) 4 (40%) 7 (70%) 8 (80%)
Stomach, Forestomach (9) (10) (10) (10)
Epithelium, Hyperkeratosis 1 (11%) 1 (10%) 2 (20%) 1 (10%)
Epithelium, Hyperplasia 1 (11%) 1 (10%) 3 (30%) 2 (20%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (9) (10) (10) (10)
Accessory Adrenal Cortical Nodule 2 (22%) 2 (20%) 2 (20%) 4 (40%)
Subcapsular, Hyperplasia 4 (44%) 7 (70%) 7 (70%) 3 (30%)
Pituitary Gland (9) (10) (10) (10)
Pars Distalis, Hypertrophy 1 (10%)
Pars Distalis, Inflammation, Chronic Active 1 (11%)
Thyroid Gland (9) (10) (10) (10)
Infiltration Cellular, Lymphocyte 2 (20%) 5 (50%) 10 (100%)
Follicle, Depletion Secretory 5 (56%) 8 (80%) 10 (100%) 10 (100%)
Follicular Cell, Hypertrophy 1 (11%) 9 (90%) 9 (90%) 10 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 97013-92 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03
Route: SKIN APPLICATION Time: 14:28:00
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 64 MG/KG 128 256
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (9) (10) (10) (10)
Cyst 1 (11%) 4 (40%) 2 (20%) 5 (50%)
Inflammation, Chronic Active 1 (11%) 1 (10%)
Pigmentation, Hemosiderin 1 (10%)
Corpus Luteum, Degeneration 1 (10%)
Thecal Cell, Hyperplasia 1 (10%)
Uterus (9) (10) (10) (10)
Endometrium, Hyperplasia, Cystic 8 (89%) 7 (70%) 8 (80%) 10 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (9) (10) (10) (10)
Hyperplasia, Lymphoid 1 (11%) 3 (30%) 2 (20%) 2 (20%)
Spleen (9) (10) (10) (10)
Atrophy 1 (11%) 1 (10%)
Hematopoietic Cell Proliferation 3 (33%) 6 (60%) 8 (80%) 8 (80%)
Thymus (8) (10) (10) (10)
Atrophy 1 (13%) 1 (10%) 2 (20%) 1 (10%)
Cyst 1 (10%) 2 (20%) 5 (50%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (9) (10) (10) (10)
Inflammation, Chronic Active 1 (10%)
Ulcer 1 (10%)
Epidermis, Hyperplasia, Focal 2 (22%) 2 (20%) 6 (60%) 3 (30%)
Site of Application - Dermis, Cyst
Epithelial Inclusion 1 (10%)
Site of Application - Epidermis, Hyperplasia 1 (10%)
Subcutaneous Tissue, Cyst Epithelial
Inclusion 1 (10%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 97013-92 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03
Route: SKIN APPLICATION Time: 14:28:00
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 64 MG/KG 128 256
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (9) (10) (10) (10)
Inflammation, Chronic Active 1 (10%) 1 (10%)
Metaplasia, Osseous 1 (10%)
Perivascular, Infiltration Cellular,
Lymphocyte 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1)
Cornea, Inflammation, Chronic Active 1 (100%)
Zymbal's Gland (2)
Cyst 1 (50%)
Inflammation, Chronic Active 1 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (9) (10) (10) (10)
Mineralization 1 (10%)
Nephropathy 5 (56%) 6 (60%) 8 (80%) 10 (100%)
Artery, Inflammation, Chronic Active 1 (10%)
Cortex, Cyst 1 (11%)
Renal Tubule, Hypertrophy 4 (40%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 97013-92 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03
Route: SKIN APPLICATION Time: 14:28:00
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 64 MG/KG 128 256
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10
Early Deaths
Moribund Sacrifice 1 2
Natural Death 1 2 2
Survivors
Terminal Sacrifice 8 8 8 8
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10)
Hematopoietic Cell Proliferation 1 (10%) 1 (10%) 1 (10%)
Inflammation, Chronic Active 8 (80%) 8 (80%) 6 (60%) 6 (60%)
Necrosis 2 (20%)
Hepatocyte, Fatty Change 1 (10%)
Hepatocyte, Vacuolization Cytoplasmic 5 (50%) 8 (80%) 6 (60%) 2 (20%)
Mesentery (1) (2)
Fat, Fibrosis 1 (100%) 1 (50%)
Fat, Inflammation, Chronic Active 1 (100%) 2 (100%)
Fat, Necrosis 1 (100%) 2 (100%)
Stomach, Forestomach (10) (10) (10) (10)
Epithelium, Hyperkeratosis 2 (20%) 1 (10%)
Epithelium, Hyperplasia 2 (20%) 1 (10%)
Tooth (2) (3) (3) (2)
Abscess, Focal 1 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Accessory Adrenal Cortical Nodule 2 (20%) 1 (10%)
Hypertrophy 6 (60%) 5 (50%) 6 (60%) 6 (60%)
Pituitary Gland (9) (10) (10) (10)
Pars Distalis, Cyst 3 (33%) 3 (30%) 1 (10%) 3 (30%)
Thyroid Gland (10) (10) (10) (10)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 97013-92 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03
Route: SKIN APPLICATION Time: 14:28:00
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 64 MG/KG 128 256
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Infiltration Cellular, Lymphocyte 2 (20%) 1 (10%)
Follicle, Cyst 1 (10%)
Follicle, Depletion Secretory 8 (80%) 7 (70%) 9 (90%) 9 (90%)
Follicular Cell, Hypertrophy 9 (90%) 8 (80%) 8 (80%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (10) (10) (10) (10)
Cyst 2 (20%) 2 (20%)
Degeneration 1 (10%) 2 (20%) 3 (30%) 5 (50%)
Inflammation, Chronic Active 3 (30%) 2 (20%)
Testes (10) (10) (10) (10)
Cyst 1 (10%) 1 (10%) 2 (20%)
Mineralization 1 (10%)
Bilateral, Germinal Epithelium, Degeneration 1 (10%) 1 (10%) 2 (20%)
Germinal Epithelium, Degeneration 1 (10%) 2 (20%) 3 (30%) 6 (60%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (10) (10) (10) (10)
Hyperplasia, Lymphoid 1 (10%) 3 (30%)
Spleen (10) (10) (10) (10)
Hematopoietic Cell Proliferation 3 (30%) 2 (20%) 2 (20%) 3 (30%)
Hyperplasia, Lymphoid 1 (10%)
Thymus (10) (10) (10) (9)
Atrophy 3 (30%) 2 (20%) 4 (40%) 3 (33%)
Cyst 7 (70%) 1 (10%) 3 (33%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (10) (10) (10) (10)
Hyperkeratosis 1 (10%) 1 (10%)
Epidermis, Hyperplasia, Focal 4 (40%) 2 (20%) 1 (10%) 2 (20%)
Site of Application - Epidermis, Hyperplasia,
Focal 1 (10%) 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 97013-92 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03
Route: SKIN APPLICATION Time: 14:28:00
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 64 MG/KG 128 256
MG/KG MG/KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Subcutaneous Tissue, Inflammation, Chronic
Active 1 (10%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10)
Inflammation, Chronic Active 2 (20%) 1 (10%) 1 (10%)
Alveolar Epithelium, Hyperplasia 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
Mineralization 1 (10%)
Nephropathy 7 (70%) 10 (100%) 9 (90%) 10 (100%)
Cortex, Cyst 3 (30%) 1 (10%)
Glomerulus, Inflammation,
Membranoproliferative 1 (10%) 1 (10%) 1 (10%)
Papilla, Mineralization 1 (10%)
Pelvis, Dilatation 1 (10%)
Renal Tubule, Hypertrophy 2 (20%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
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