TDMS Study 97013-92 Pathology Tables
NTP Experiment-Test: 97013-92 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03 Route: SKIN APPLICATION Time: 14:30:21 FINAL#1 MICE Facility: Battelle Columbus Laboratory Chemical CAS #: 7789-38-0 Lock Date: 07/30/01 Cage Range: All Reasons For Removal: 25019 Moribund Sacrifice 25020 Natural Death 25021 Terminal Sacrifice Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 97013-92 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03 Route: SKIN APPLICATION Time: 14:30:21 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 64 MG/KG 128 256 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 10 10 10 10 Early Deaths Moribund Sacrifice 1 1 2 1 Natural Death 1 2 1 Survivors Terminal Sacrifice 7 7 8 8 Animals Examined Microscopically 9 10 10 10 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (9) (10) (10) (10) Salivary Glands (1) (1) (1) Carcinoma 1 (100%) 1 (100%) Stomach, Forestomach (9) (10) (10) (10) Squamous Cell Papilloma 2 (22%) 1 (10%) 4 (40%) 3 (30%) Squamous Cell Papilloma, Multiple 1 (10%) 3 (30%) 1 (10%) Tooth (2) (4) (3) (3) Odontogenic Tumor 2 (100%) 3 (75%) 2 (67%) 3 (100%) Odontogenic Tumor, Multiple 1 (33%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM None ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ Page 2 NTP Experiment-Test: 97013-92 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03 Route: SKIN APPLICATION Time: 14:30:21 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 64 MG/KG 128 256 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Ovary (9) (10) (10) (10) Hemangioma 1 (10%) Luteoma, Multiple 1 (10%) Teratoma Benign 1 (11%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Spleen (9) (10) (10) (10) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (9) (10) (10) (10) Squamous Cell Papilloma 2 (22%) 2 (20%) 3 (30%) 1 (10%) Squamous Cell Papilloma, Multiple 4 (44%) 3 (30%) 2 (20%) 3 (30%) Site of Application, Squamous Cell Papilloma 1 (11%) 1 (10%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (9) (10) (10) (10) Alveolar/Bronchiolar Adenoma 1 (10%) Carcinoma, Metastatic, Zymbal's Gland 1 (11%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Zymbal's Gland (2) Carcinoma 1 (50%) ____________________________________________________________________________________________________________________________________ Page 3 NTP Experiment-Test: 97013-92 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03 Route: SKIN APPLICATION Time: 14:30:21 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 64 MG/KG 128 256 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (9) (10) (10) (10) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(9) *(10) *(10) *(10) Leukemia Erythrocytic 1 (11%) 1 (10%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 4 NTP Experiment-Test: 97013-92 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03 Route: SKIN APPLICATION Time: 14:30:21 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 64 MG/KG 128 256 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 7 7 10 9 Total Primary Neoplasms 14 12 17 14 Total Animals with Benign Neoplasms 6 5 8 8 Total Benign Neoplasms 10 8 13 10 Total Animals with Malignant Neoplasms 2 1 1 1 Total Malignant Neoplasms 2 1 1 1 Total Animals with Metastatic Neoplasms 1 Total Metastatic Neoplasm 1 Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant 2 3 3 3 Total Uncertain Neoplasms 2 3 3 3 ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 5 NTP Experiment-Test: 97013-92 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03 Route: SKIN APPLICATION Time: 14:30:21 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 64 MG/KG 128 256 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 10 10 10 10 Early Deaths Moribund Sacrifice 1 2 Natural Death 1 2 2 Survivors Terminal Sacrifice 8 8 8 8 Animals Examined Microscopically 10 10 10 10 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (10) (10) (10) (10) Salivary Glands (2) Carcinoma 1 (50%) Carcinosarcoma 1 (50%) Stomach, Forestomach (10) (10) (10) (10) Squamous Cell Papilloma 2 (20%) 2 (20%) 1 (10%) 2 (20%) Squamous Cell Papilloma, Multiple 1 (10%) 1 (10%) 1 (10%) 2 (20%) Tooth (2) (3) (3) (2) Odontogenic Tumor 1 (50%) 2 (67%) 3 (100%) 2 (100%) Odontogenic Tumor, Multiple 1 (50%) 1 (33%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (10) (10) (10) (10) Adrenal Medulla (10) (10) (10) (10) Pituitary Gland (9) (10) (10) (10) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ Page 6 NTP Experiment-Test: 97013-92 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03 Route: SKIN APPLICATION Time: 14:30:21 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 64 MG/KG 128 256 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM None ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Spleen (10) (10) (10) (10) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (10) (10) (10) (10) Keratoacanthoma 1 (10%) Squamous Cell Carcinoma 1 (10%) 1 (10%) Squamous Cell Papilloma 3 (30%) 7 (70%) 4 (40%) 4 (40%) Squamous Cell Papilloma, Multiple 4 (40%) 2 (20%) 2 (20%) 2 (20%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (10) (10) (10) (10) Alveolar/Bronchiolar Adenoma 1 (10%) 2 (20%) 1 (10%) 1 (10%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ Page 7 NTP Experiment-Test: 97013-92 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03 Route: SKIN APPLICATION Time: 14:30:21 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 64 MG/KG 128 256 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (10) (10) (10) (10) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(10) *(10) *(10) *(10) Leukemia Erythrocytic 1 (10%) 1 (10%) 1 (10%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 8 NTP Experiment-Test: 97013-92 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03 Route: SKIN APPLICATION Time: 14:30:21 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 64 MG/KG 128 256 MG/KG MG/KG ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 9 10 7 7 Total Primary Neoplasms 16 19 14 14 Total Animals with Benign Neoplasms 7 9 6 6 Total Benign Neoplasms 11 14 10 11 Total Animals with Malignant Neoplasms 3 2 1 1 Total Malignant Neoplasms 3 2 1 1 Total Animals with Metastatic Neoplasms Total Metastatic Neoplasm Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant 2 3 3 2 Total Uncertain Neoplasms 2 3 3 2 ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 9 ------------------------------------------------------------ ---------- END OF REPORT ---------- 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