TDMS Study 97013-94 Pathology Tables
NTP Experiment-Test: 97013-94 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03
Route: DOSED WATER Time: 14:40:44
FINAL#1 MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 7789-38-0
Lock Date: 07/30/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 97013-94 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03
Route: DOSED WATER Time: 14:40:44
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10
Early Deaths
Moribund Sacrifice 3 4 4 7
Natural Death 1 2 1
Survivors
Terminal Sacrifice 7 5 4 2
Animals Examined Microscopically 10 10 10 10
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ALIMENTARY SYSTEM
Liver (10) (10) (10) (10)
Hematopoietic Cell Proliferation 3 (30%) 4 (40%) 6 (60%) 1 (10%)
Inflammation, Chronic Active 10 (100%) 6 (60%) 7 (70%) 5 (50%)
Mineralization 1 (10%)
Hepatocyte, Fatty Change 1 (10%)
Hepatocyte, Necrosis 1 (10%) 1 (10%) 1 (10%)
Hepatocyte, Vacuolization Cytoplasmic 7 (70%) 4 (40%) 4 (40%) 3 (30%)
Mesentery (2)
Fat, Fibrosis 1 (50%)
Fat, Necrosis 2 (100%)
Stomach, Forestomach (10) (10) (10) (10)
Epithelium, Hyperkeratosis 1 (10%) 2 (20%) 1 (10%) 7 (70%)
Epithelium, Hyperplasia 5 (50%) 6 (60%) 4 (40%) 8 (80%)
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Accessory Adrenal Cortical Nodule 1 (10%) 1 (10%)
Mineralization 1 (10%) 2 (20%)
Subcapsular, Hyperplasia 5 (50%) 6 (60%) 1 (10%)
Parathyroid Gland (1)
Necrosis 1 (100%)
Pituitary Gland (10) (10) (9) (10)
Pars Distalis, Cyst 3 (30%) 2 (20%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 97013-94 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03
Route: DOSED WATER Time: 14:40:44
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Distalis, Hypertrophy 2 (22%) 6 (60%)
Pars Distalis, Mineralization 1 (10%)
Thyroid Gland (10) (9) (10) (10)
Infiltration Cellular, Lymphocyte 2 (22%) 7 (70%) 8 (80%)
Follicle, Degeneration 1 (11%)
Follicle, Depletion Secretory 1 (10%) 8 (89%) 9 (90%) 10 (100%)
Follicular Cell, Hypertrophy 8 (89%) 10 (100%) 10 (100%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (10) (9) (10) (10)
Atrophy 1 (10%) 1 (10%) 2 (20%)
Cyst 1 (10%) 1 (11%)
Inflammation, Chronic Active 1 (10%) 3 (33%) 1 (10%)
Uterus (10) (10) (10) (10)
Inflammation, Suppurative 3 (30%)
Endometrium, Hyperplasia, Cystic 8 (80%) 7 (70%) 5 (50%) 2 (20%)
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HEMATOPOIETIC SYSTEM
Lymph Node (1) (2)
Mediastinal, Hyperplasia, Lymphoid 1 (50%)
Lymph Node, Mandibular (9) (10) (10) (9)
Hyperplasia, Lymphoid 2 (22%) 4 (40%) 2 (20%) 2 (22%)
Inflammation, Chronic Active 1 (10%)
Lymph Node, Mesenteric (9) (9) (10) (10)
Hyperplasia, Lymphoid 1 (11%)
Infiltration Cellular, Polymorphonuclear 1 (11%)
Spleen (10) (10) (10) (10)
Atrophy 1 (10%)
Hematopoietic Cell Proliferation 3 (30%) 3 (30%) 6 (60%) 4 (40%)
Thymus (10) (10) (10) (10)
Atrophy 2 (20%) 5 (50%) 6 (60%) 9 (90%)
Cyst 1 (10%) 1 (10%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 97013-94 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03
Route: DOSED WATER Time: 14:40:44
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (6) (8) (8) (4)
Inflammation, Chronic Active 1 (17%) 1 (13%)
Epidermis, Hyperplasia, Focal 5 (83%) 3 (38%) 2 (25%) 3 (75%)
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MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10)
Alveolar Epithelium, Hyperplasia 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
Mineralization 1 (10%) 2 (20%)
Nephropathy 6 (60%) 6 (60%) 8 (80%) 8 (80%)
Cortex, Cyst 2 (20%)
Glomerulus, Inflammation,
Membranoproliferative 1 (10%) 2 (20%) 1 (10%)
Renal Tubule, Degeneration 7 (70%)
Renal Tubule, Hypertrophy 2 (20%) 5 (50%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 97013-94 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03
Route: DOSED WATER Time: 14:40:44
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10
Early Deaths
Moribund Sacrifice 2 2 4 3
Natural Death 2 1 3
Survivors
Terminal Sacrifice 6 7 6 4
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10)
Hematopoietic Cell Proliferation 1 (10%) 2 (20%) 1 (10%)
Inflammation, Chronic Active 5 (50%) 5 (50%) 7 (70%) 4 (40%)
Hepatocyte, Fatty Change 2 (20%) 1 (10%)
Hepatocyte, Necrosis 1 (10%)
Hepatocyte, Vacuolization Cytoplasmic 5 (50%) 6 (60%) 6 (60%) 3 (30%)
Stomach, Forestomach (10) (10) (10) (10)
Epithelium, Hyperkeratosis 2 (20%) 2 (20%) 1 (10%) 2 (20%)
Epithelium, Hyperplasia 4 (40%) 2 (20%) 3 (30%) 5 (50%)
Epithelium, Hyperplasia, Focal 1 (10%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Hypertrophy 5 (50%) 7 (70%) 6 (60%) 1 (10%)
Pituitary Gland (10) (10) (10) (10)
Pars Distalis, Cyst 1 (10%)
Pars Distalis, Hypertrophy 2 (20%)
Thyroid Gland (10) (10) (10) (9)
Infiltration Cellular, Lymphocyte 4 (44%)
Follicle, Cyst 1 (10%)
Follicle, Depletion Secretory 3 (30%) 4 (40%) 4 (40%) 7 (78%)
Follicular Cell, Hypertrophy 6 (60%) 8 (80%) 8 (89%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 97013-94 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03
Route: DOSED WATER Time: 14:40:44
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (10) (10) (10) (10)
Cyst 1 (10%)
Degeneration 1 (10%) 1 (10%) 7 (70%)
Granuloma Sperm 1 (10%)
Inflammation, Chronic Active 1 (10%)
Preputial Gland (2) (3) (1)
Atrophy 1 (50%) 1 (33%)
Duct, Ectasia 2 (100%) 2 (67%) 1 (100%)
Testes (10) (10) (10) (10)
Mineralization 1 (10%)
Bilateral, Germinal Epithelium, Degeneration 3 (30%) 8 (80%)
Germinal Epithelium, Degeneration 1 (10%) 1 (10%) 2 (20%)
Interstitial Cell, Hyperplasia 3 (30%)
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HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (9) (10) (10) (7)
Hyperplasia, Lymphoid 2 (22%) 4 (40%) 1 (14%)
Lymph Node, Mesenteric (9) (10) (10) (9)
Hyperplasia, Lymphoid 1 (10%)
Spleen (10) (10) (10) (10)
Atrophy 1 (10%)
Hematopoietic Cell Proliferation 1 (10%) 2 (20%)
Thymus (10) (10) (9) (9)
Atrophy 5 (50%) 1 (10%) 3 (33%) 6 (67%)
Cyst 3 (30%) 1 (10%) 1 (11%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (9) (9) (9) (8)
Inflammation, Chronic Active 1 (11%) 1 (11%)
Epidermis, Hyperplasia, Focal 3 (33%) 4 (44%) 3 (33%) 1 (13%)
Hair Follicle, Sebaceous Gland, Atrophy 1 (11%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 97013-94 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03
Route: DOSED WATER Time: 14:40:44
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10)
Inflammation, Chronic Active 1 (10%) 1 (10%)
Thrombosis 1 (10%)
Alveolar Epithelium, Hyperplasia 1 (10%)
Alveolus, Infiltration Cellular, Histiocyte 1 (10%)
Perivascular, Infiltration Cellular,
Lymphocyte 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
Hydronephrosis 2 (20%)
Inflammation 1 (10%)
Mineralization 1 (10%)
Nephropathy 7 (70%) 6 (60%) 7 (70%) 10 (100%)
Cortex, Cyst 1 (10%) 1 (10%)
Glomerulus, Inflammation,
Membranoproliferative 2 (20%) 2 (20%)
Renal Tubule, Degeneration 1 (10%) 8 (80%)
Renal Tubule, Hypertrophy 1 (10%) 6 (60%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
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