TDMS Study 97013-94 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus WATER DISINFECTION MODEL (SODIUM BROMATE) DATE: 12/08/03
EXPERIMENT: 97013 TEST: 94 TIME: 14:43:11
TEST TYPE: 26-39 WEEKS CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-65406 ROUTE: DOSED WATER NTP C#: 97013H
PATHOLOGIST: MISSING CAS: 7789-38-0
------------------------------------------------------------------------------------------------------------------------------------
FINAL#1 MICE
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus WATER DISINFECTION MODEL (SODIUM BROMATE) DATE: 12/08/03
EXPERIMENT: 97013 TEST: 94 TIME: 14:43:11
TEST TYPE: 26-39 WEEKS CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-65406 ROUTE: DOSED WATER NTP C#: 97013H
PATHOLOGIST: MISSING CAS: 7789-38-0
Mice(TG.AC HETEROZYGOUS TRANSGENIC)
-----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE
BASED ON NUMBER OF TISSUES EXAMINED. IN OTHER TISSUES/ORGANS RATES
ARE BASED ON THE NUMBER OF ANIMALS NECROPSIED.
---------------
Lung
Ovary
Salivary Glands
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: Battelle Columbus WATER DISINFECTION MODEL (SODIUM BROMATE) DATE: 12/08/03
EXPERIMENT: 97013 TEST: 94 TIME: 14:43:11
TEST TYPE: 26-39 WEEKS CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-65406 ROUTE: DOSED WATER NTP C#: 97013H
PATHOLOGIST: MISSING CAS: 7789-38-0
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF WATER DISINFECTION MODEL (SODIUM BR
===============================================================
Male Mice
------------
Organ Morphology
----- ----------
Stomach, Forestomach Squamous Cell Papilloma
===============================================================
Female Mice
------------
Organ Morphology
----- ----------
Skin Squamous Cell Papilloma
All Organs Benign Tumors
Malignant and Benign Tumors
===============================================================
Date: 12/08/03 EXPERIMENT: 97013 TEST: 94 Page 1
Statistical Analysis of Primary Tumors in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - WATER DISINFECTION MODEL (SODIUM BR
Terminal Sacrifice at 43 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 80 MG/L 400 MG/L 800 MG/L |0 MG/L 80 MG/L 400 MG/L 800 MG/L |
| | | |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/10 (10%) 3/10 (30%) 1/10 (10%) 0/10 (0%) |1/10 (10%) 1/10 (10%) 1/10 (10%) 0/10 (0%) |
|POLY-3 RATE (b) | 1/7.25 3/8.06 1/7.78 0/7.49 |1/7.62 1/7.61 1/6.52 0/4.58 |
|POLY-3 PERCENT (g) | 13.8% 37.2% 12.9% 0.0% |13.1% 13.2% 15.4% 0.0% |
|TERMINAL (d) | 1/6 (17%) 2/7 (29%) 1/6 (17%) 0/4 (0%) |1/7 (14%) 1/5 (20%) 1/4 (25%) 0/2 (0%) |
|FIRST INCIDENCE | 295 (T) 192 295 (T) --- |295 (T) 295 (T) 295 (T) --- |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.183N P=0.340 P=0.771 P=0.581N |P=0.575N P=0.692 P=0.638 P=0.748N |
|POLY 3 | P=0.108N P=0.326 P=0.750N P=0.493N |P=0.457N P=0.765 P=0.730 P=0.597N |
|POLY 1.5 | P=0.109N P=0.298 P=0.752N P=0.492N |P=0.390N P=0.762N P=0.750 P=0.563N |
|POLY 6 | P=0.116N P=0.367 P=0.748N P=0.501N |P=0.527N P=0.759 P=0.713 P=0.629N |
|LOGISTIC REGRESSION| P=0.115N P=0.281 P=0.771 (e) |P=0.575N P=0.692 P=0.638 (e) |
|COCH-ARM / FISHERS | P=0.124N P=0.291 P=0.763N P=0.500N |P=0.297N P=0.763N P=0.763N P=0.500N |
|ORDER RESTRICTED | P=0.137N (e) (e) (e) |P=0.414N (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 80 MG/L 400 MG/L 800 MG/L |0 MG/L 80 MG/L 400 MG/L 800 MG/L |
| | | |
|=================================================================================================================================|
| |
|Salivary Glands |
| Carcinoma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/0 (0%) 1/1 (100%) 0/0 (0%) 0/0 (0%) |1/1 (100%) 0/1 (0%) 2/2 (100%) 2/2 (100%) |
|POLY-3 RATE (b) | 0/0.00 1/1.00 0/0.00 0/0.00 |1/1.00 0/0.65 2/2.00 2/2.00 |
|POLY-3 PERCENT (g) | 0.0% 100.0% 0.0% 0.0% |100.0% 0.0% 100.0% 100.0% |
|TERMINAL (d) | 0/0 (0%) 1/1 (100%) 0/0 (0%) 0/0 (0%) |0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- 295 (T) --- --- |246 --- 115 197 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | (e) (e) (e) (e) |P=0.278 P=0.500N (e) (e) |
|POLY 3 | (e) (e) (e) (e) |P=0.319 P=1.000N (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) |P=0.319N P=1.000N (e) (e) |
|POLY 6 | (e) (e) (e) (e) |P=0.319 P=1.000N (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) |P=0.329 (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) |P=0.319 P=0.500N (e) (e) |
|ORDER RESTRICTED | (e) (e) (e) (e) |P=0.177 (e) (e) (e) |
|=================================================================================================================================|
Date: 12/08/03 EXPERIMENT: 97013 TEST: 94 Page 2
Statistical Analysis of Primary Tumors in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - WATER DISINFECTION MODEL (SODIUM BR
Terminal Sacrifice at 43 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 80 MG/L 400 MG/L 800 MG/L |0 MG/L 80 MG/L 400 MG/L 800 MG/L |
| | | |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 5/10 (50%) 8/10 (80%) 6/10 (60%) 7/10 (70%) |5/10 (50%) 8/10 (80%) 7/10 (70%) 1/10 (10%) |
|POLY-3 RATE (b) | 5/7.25 8/8.06 6/8.20 7/9.08 |5/7.62 8/8.12 7/9.06 1/4.58 |
|POLY-3 PERCENT (g) | 69.0% 99.3% 73.1% 77.1% |65.6% 98.5% 77.3% 21.9% |
|TERMINAL (d) | 5/6 (83%) 7/7 (100%) 5/6 (83%) 2/4 (50%) |5/7 (71%) 5/5 (100%) 2/4 (50%) 1/2 (50%) |
|FIRST INCIDENCE | 295 (T) 192 246 218 |295 (T) 255 144 295 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.146 P=0.223 P=0.534 P=0.205 |P=0.444N P=0.047 * P=0.130 P=0.605N |
|POLY 3 | P=0.442N P=0.122 P=0.656 P=0.578 |P=0.076N P=0.122 P=0.508 P=0.187N |
|POLY 1.5 | P=0.550N P=0.093 P=0.595 P=0.467 |P=0.023N* P=0.121 P=0.468 P=0.118N |
|POLY 6 | P=0.331N P=0.246 P=0.730 P=0.705 |P=0.179N P=0.137 P=0.548 P=0.289N |
|LOGISTIC REGRESSION| P=0.566 P=0.069 P=0.645 P=0.361 |P=0.041N* P=0.089 P=0.284 P=0.605N |
|COCH-ARM / FISHERS | P=0.450 P=0.175 P=0.500 P=0.325 |P=0.011N* P=0.175 P=0.325 P=0.070N |
|ORDER RESTRICTED | P=0.366 (e) (e) (e) |P=0.018N* (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 80 MG/L 400 MG/L 800 MG/L |0 MG/L 80 MG/L 400 MG/L 800 MG/L |
| | | |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Squamous Cell Papilloma |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 4/10 (40%) 4/10 (40%) 1/10 (10%) 1/10 (10%) |1/10 (10%) 4/10 (40%) 3/10 (30%) 1/10 (10%) |
|POLY-3 RATE (b) | 4/7.81 4/8.06 1/8.20 1/8.09 |1/7.62 4/8.04 3/6.68 1/4.58 |
|POLY-3 PERCENT (g) | 51.2% 49.6% 12.2% 12.4% |13.1% 49.8% 44.9% 21.9% |
|TERMINAL (d) | 3/6 (50%) 3/7 (43%) 0/6 (0%) 0/4 (0%) |1/7 (14%) 2/5 (40%) 1/4 (25%) 1/2 (50%) |
|FIRST INCIDENCE | 224 192 246 218 |295 (T) 255 287 295 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.082N P=0.602N P=0.154N P=0.239N |P=0.364 P=0.123 P=0.181 P=0.460 |
|POLY 3 | P=0.029N* P=0.664N P=0.117N P=0.120N |P=0.547 P=0.151 P=0.227 P=0.641 |
|POLY 1.5 | P=0.029N* P=0.678 P=0.123N P=0.123N |P=0.531N P=0.149 P=0.259 P=0.690 |
|POLY 6 | P=0.033N* P=0.626N P=0.112N P=0.126N |P=0.433 P=0.155 P=0.210 P=0.587 |
|LOGISTIC REGRESSION| P=0.039N* P=0.671 P=0.135N P=0.143N |P=0.556 P=0.142 P=0.194 P=0.460 |
|COCH-ARM / FISHERS | P=0.043N* P=0.675N P=0.152N P=0.152N |P=0.333N P=0.152 P=0.291 P=0.763N |
|ORDER RESTRICTED | P=0.061N (e) (e) (e) |P=0.284 (e) (e) (e) |
|=================================================================================================================================|
Date: 12/08/03 EXPERIMENT: 97013 TEST: 94 Page 3
Statistical Analysis of Primary Tumors in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - WATER DISINFECTION MODEL (SODIUM BR
Terminal Sacrifice at 43 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 80 MG/L 400 MG/L 800 MG/L |0 MG/L 80 MG/L 400 MG/L 800 MG/L |
| | | |
|=================================================================================================================================|
| |
|Tooth |
| Odontogenic Tumor |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 3/10 (30%) 2/10 (20%) 4/10 (40%) 2/10 (20%) |3/10 (30%) 5/10 (50%) 2/10 (20%) 5/10 (50%) |
|POLY-3 RATE (b) | 3/8.28 2/8.06 4/9.12 2/8.26 |3/8.59 5/7.69 2/6.60 5/7.93 |
|POLY-3 PERCENT (g) | 36.2% 24.8% 43.9% 24.2% |34.9% 65.1% 30.3% 63.1% |
|TERMINAL (d) | 1/6 (17%) 1/7 (14%) 1/6 (17%) 0/4 (0%) |2/7 (29%) 4/5 (80%) 1/4 (25%) 1/2 (50%) |
|FIRST INCIDENCE | 224 192 188 218 |93 287 287 93 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.539N P=0.484N P=0.553 P=0.513N |P=0.066 P=0.190 P=0.659N P=0.128 |
|POLY 3 | P=0.502N P=0.514N P=0.563 P=0.501N |P=0.333 P=0.236 P=0.634N P=0.257 |
|POLY 1.5 | P=0.487N P=0.520N P=0.548 P=0.491N |P=0.363 P=0.260 P=0.582N P=0.277 |
|POLY 6 | P=0.539N P=0.504N P=0.572 P=0.528N |P=0.295 P=0.215 P=0.666N P=0.226 |
|LOGISTIC REGRESSION| P=0.528N P=0.501N P=0.489 P=0.506N |P=0.361 P=0.325 P=0.509N P=0.414 |
|COCH-ARM / FISHERS | P=0.518N P=0.500N P=0.500 P=0.500N |P=0.418 P=0.325 P=0.500N P=0.325 |
|ORDER RESTRICTED | P=0.486N (e) (e) (e) |P=0.177 (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 80 MG/L 400 MG/L 800 MG/L |0 MG/L 80 MG/L 400 MG/L 800 MG/L |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Leukemia: Erythrocytic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 2/10 (20%) 0/10 (0%) 2/10 (20%) 2/10 (20%) |0/10 (0%) 2/10 (20%) 2/10 (20%) 1/10 (10%) |
|POLY-3 RATE (b) | 2/8.97 0/7.33 2/8.84 2/8.83 |0/7.62 2/8.49 2/7.48 1/4.75 |
|POLY-3 PERCENT (g) | 22.3% 0.0% 22.6% 22.6% |0.0% 23.6% 26.7% 21.1% |
|TERMINAL (d) | 0/6 (0%) 0/7 (0%) 0/6 (0%) 0/4 (0%) |0/7 (0%) 1/5 (20%) 0/4 (0%) 0/2 (0%) |
|FIRST INCIDENCE | 93 --- 144 127 |--- 144 144 277 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.391 P=0.265N P=0.668N P=0.657N |P=0.302 P=0.215 P=0.235 P=0.331 |
|POLY 3 | P=0.407 P=0.274N P=0.701 P=0.701 |P=0.322 P=0.250 P=0.216 P=0.407 |
|POLY 1.5 | P=0.404 P=0.269N P=0.700 P=0.703 |P=0.382 P=0.246 P=0.227 P=0.439 |
|POLY 6 | P=0.388 P=0.268N P=0.704 P=0.694 |P=0.275 P=0.247 P=0.208 P=0.379 |
|LOGISTIC REGRESSION| P=0.180 P=0.115N P=0.685 P=0.613 |P=0.532 P=0.223 P=0.228 P=0.393 |
|COCH-ARM / FISHERS | P=0.347 P=0.237N P=0.709N P=0.709N |P=0.524 P=0.237 P=0.237 P=0.500 |
|ORDER RESTRICTED | P=0.447 (e) (e) (e) |P=0.267 (e) (e) (e) |
|=================================================================================================================================|
Date: 12/08/03 EXPERIMENT: 97013 TEST: 94 Page 4
Statistical Analysis of Primary Tumors in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - WATER DISINFECTION MODEL (SODIUM BR
Terminal Sacrifice at 43 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 80 MG/L 400 MG/L 800 MG/L |0 MG/L 80 MG/L 400 MG/L 800 MG/L |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 7/10 (70%) 8/10 (80%) 7/10 (70%) 8/10 (80%) |6/10 (60%) 8/10 (80%) 8/10 (80%) 2/10 (20%) |
|POLY-3 RATE (b) | 7/7.81 8/8.06 7/8.20 8/9.08 |6/7.62 8/8.12 8/9.06 2/4.58 |
|POLY-3 PERCENT (g) | 89.6% 99.3% 85.3% 88.1% |78.8% 98.5% 88.3% 43.7% |
|TERMINAL (d) | 6/6 (100%) 7/7 (100%) 6/6 (100%) 3/4 (75%) |6/7 (86%) 5/5 (100%) 3/4 (75%) 2/2 (100%) |
|FIRST INCIDENCE | 224 192 246 218 |295 (T) 255 144 295 (T) |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.117 P=0.746 P=0.729N P=0.270 |P=0.466 P=0.078 P=0.078 P=0.748 |
|POLY 3 | P=0.442N P=0.652 P=0.727N P=0.769N |P=0.140N P=0.310 P=0.556 P=0.257N |
|POLY 1.5 | P=0.542N P=0.477 P=0.691N P=0.706 |P=0.043N* P=0.294 P=0.497 P=0.150N |
|POLY 6 | P=0.333N P=0.984 P=0.783N P=0.673N |P=0.329N P=0.354 P=0.618 P=0.433N |
|LOGISTIC REGRESSION| P=0.548N P=0.315 P=0.617N P=0.644 |P=0.085N P=0.212 P=0.247 P=0.748 |
|COCH-ARM / FISHERS | P=0.482 P=0.500 P=0.686N P=0.500 |P=0.018N* P=0.314 P=0.314 P=0.085N |
|ORDER RESTRICTED | P=0.421N (e) (e) (e) |P=0.033N* (e) (e) (e) |
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 80 MG/L 400 MG/L 800 MG/L |0 MG/L 80 MG/L 400 MG/L 800 MG/L |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 2/10 (20%) 2/10 (20%) 2/10 (20%) 2/10 (20%) |2/10 (20%) 5/10 (50%) 5/10 (50%) 3/10 (30%) |
|POLY-3 RATE (b) | 2/8.97 2/8.30 2/8.84 2/8.83 |2/8.04 5/8.92 5/9.92 3/5.66 |
|POLY-3 PERCENT (g) | 22.3% 24.1% 22.6% 22.6% |24.9% 56.0% 50.4% 53.0% |
|TERMINAL (d) | 0/6 (0%) 1/7 (14%) 0/6 (0%) 0/4 (0%) |1/7 (14%) 2/5 (40%) 0/4 (0%) 0/2 (0%) |
|FIRST INCIDENCE | 93 93 144 127 |246 144 115 197 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.580N P=0.679 P=0.668N P=0.657N |P=0.224 P=0.174 P=0.181 P=0.206 |
|POLY 3 | P=0.589N P=0.677 P=0.701 P=0.701 |P=0.347 P=0.212 P=0.275 P=0.317 |
|POLY 1.5 | P=0.584N P=0.676 P=0.700 P=0.703 |P=0.403 P=0.203 P=0.262 P=0.373 |
|POLY 6 | P=0.588 P=0.689 P=0.704 P=0.694 |P=0.307 P=0.209 P=0.273 P=0.278 |
|LOGISTIC REGRESSION| P=0.436 P=0.661N P=0.685 P=0.613 |P=0.584 P=0.175 P=0.178 P=0.358 |
|COCH-ARM / FISHERS | P=0.599 P=0.709N P=0.709N P=0.709N |P=0.582 P=0.175 P=0.175 P=0.500 |
|ORDER RESTRICTED | P=0.730 (e) (e) (e) |P=0.292 (e) (e) (e) |
|=================================================================================================================================|
Date: 12/08/03 EXPERIMENT: 97013 TEST: 94 Page 5
Statistical Analysis of Primary Tumors in Mice(TG.AC HETEROZYGOUS TRANSGENIC) - WATER DISINFECTION MODEL (SODIUM BR
Terminal Sacrifice at 43 weeks
|=================================================================================================================================|
| | | |
| | Males | Females |
|Dose | 0 MG/L 80 MG/L 400 MG/L 800 MG/L |0 MG/L 80 MG/L 400 MG/L 800 MG/L |
| | | |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # # # |# # # # |
|----------- | | |
|OVERALL (a) | 10/10 (100%) 9/10 (90%) 10/10 (100%) 9/10 (90%) |8/10 (80%) 9/10 (90%) 9/10 (90%) 8/10 (80%) |
|POLY-3 RATE (b) | 10/10.00 9/9.03 10/10.00 9/10.00 |8/9.01 9/9.00 9/10.00 8/8.31 |
|POLY-3 PERCENT (g) | 100.0% 99.7% 100.0% 90.0% |88.8% 100.0% 90.0% 96.3% |
|TERMINAL (d) | 6/6 (100%) 7/7 (100%) 6/6 (100%) 3/4 (75%) |6/7 (86%) 5/5 (100%) 3/4 (75%) 2/2 (100%) |
|FIRST INCIDENCE | 93 93 144 127 |93 144 115 93 |
|-------------------| | |
|STATISTICAL TESTS | | |
|-------------------| | |
|LIFE TABLE | P=0.335 P=0.375N (e) P=0.561 |P=0.025 * P=0.256 P=0.199 P=0.052 |
|POLY 3 | P=0.200N P=1.000N (e) P=0.500N |P=0.598 P=0.498 P=0.735 P=0.631 |
|POLY 1.5 | P=0.232N P=1.000N (e) P=0.500N |P=0.648N P=0.488 P=0.718 P=0.674 |
|POLY 6 | P=0.194N P=1.000N (e) P=0.500N |P=0.518 P=0.500 P=0.737 P=0.560 |
|LOGISTIC REGRESSION| P=0.380N (e) (e) (e) |P=0.505 P=0.542 P=0.496 P=0.558 |
|COCH-ARM / FISHERS | P=0.463N P=0.500N (e) P=0.500N |P=0.522N P=0.500 P=0.500 P=0.709N |
|ORDER RESTRICTED | P=0.121N (e) (e) (e) |P=0.419 (e) (e) (e) |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Number of tumor-bearing animals / Poly-3 number
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death.
Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e) Value of Statistic cannot be computed.
(g) Poly-3 adjusted lifetime tumor incidence.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).