TDMS Study 97013-94 Pathology Tables
NTP Experiment-Test: 97013-94 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: 26-39 WEEKS WITH AVERAGE SEVERITY GRADES[b] Date: 12/08/03
Route: DOSED WATER WATER DISINFECTION MODEL (SODIUM BROMATE) Time: 14:45:56
FINAL#1 MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 7789-38-0
Lock Date: 07/30/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 1
NTP Experiment-Test: 97013-94 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: 26-39 WEEKS WITH AVERAGE SEVERITY GRADES[b] Date: 12/08/03
Route: DOSED WATER WATER DISINFECTION MODEL (SODIUM BROMATE) Time: 14:45:56
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10
Early Deaths
Moribund Sacrifice 3 4 4 7
Natural Death 1 2 1
Survivors
Terminal Sacrifice 7 5 4 2
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10)
Hematopoietic Cell Proliferation 3 [1.0] 4 [1.3] 6 [1.0] 1 [1.0]
Inflammation, Chronic Active 10 [1.1] 6 [1.0] 7 [1.0] 5 [1.0]
Mineralization 1 [2.0]
Hepatocyte, Fatty Change 1 [2.0]
Hepatocyte, Necrosis 1 [1.0] 1 [1.0] 1 [1.0]
Hepatocyte, Vacuolization Cytoplasmic 7 [1.4] 4 [1.0] 4 [1.3] 3 [1.3]
Mesentery (2)
Fat, Fibrosis 1 [2.0]
Fat, Necrosis 2 [4.0]
Stomach, Forestomach (10) (10) (10) (10)
Epithelium, Hyperkeratosis 1 [2.0] 2 [1.0] 1 [1.0] 7 [1.3]
Epithelium, Hyperplasia 5 [1.8] 6 [2.0] 4 [2.0] 8 [2.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Accessory Adrenal Cortical Nodule 1 [1.0] 1 [2.0]
Mineralization 1 [1.0] 2 [1.0]
Subcapsular, Hyperplasia 5 [1.2] 6 [1.0] 1 [1.0]
Parathyroid Gland (1)
Necrosis 1 [2.0]
Pituitary Gland (10) (10) (9) (10)
Pars Distalis, Cyst 3 [1.0] 2 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 2
NTP Experiment-Test: 97013-94 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: 26-39 WEEKS WITH AVERAGE SEVERITY GRADES[b] Date: 12/08/03
Route: DOSED WATER WATER DISINFECTION MODEL (SODIUM BROMATE) Time: 14:45:56
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Distalis, Hypertrophy 2 [1.0] 6 [2.2]
Pars Distalis, Mineralization 1 [1.0]
Thyroid Gland (10) (9) (10) (10)
Infiltration Cellular, Lymphocyte 2 [1.0] 7 [1.1] 8 [1.4]
Follicle, Degeneration 1 [2.0]
Follicle, Depletion Secretory 1 [2.0] 8 [1.3] 9 [3.0] 10 [3.3]
Follicular Cell, Hypertrophy 8 [1.0] 10 [2.6] 10 [3.3]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (10) (9) (10) (10)
Atrophy 1 [2.0] 1 [3.0] 2 [2.0]
Cyst 1 [3.0] 1 [2.0]
Inflammation, Chronic Active 1 [2.0] 3 [3.7] 1 [4.0]
Uterus (10) (10) (10) (10)
Inflammation, Suppurative 3 [2.7]
Endometrium, Hyperplasia, Cystic 8 [2.1] 7 [2.1] 5 [1.8] 2 [1.5]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (1) (2)
Mediastinal, Hyperplasia, Lymphoid 1 [2.0]
Lymph Node, Mandibular (9) (10) (10) (9)
Hyperplasia, Lymphoid 2 [2.5] 4 [3.5] 2 [2.0] 2 [3.0]
Inflammation, Chronic Active 1 [2.0]
Lymph Node, Mesenteric (9) (9) (10) (10)
Hyperplasia, Lymphoid 1 [3.0]
Infiltration Cellular, Polymorphonuclear 1 [3.0]
Spleen (10) (10) (10) (10)
Atrophy 1 [3.0]
Hematopoietic Cell Proliferation 3 [2.3] 3 [2.7] 6 [1.8] 4 [2.0]
Thymus (10) (10) (10) (10)
Atrophy 2 [2.0] 5 [2.6] 6 [2.5] 9 [2.9]
Cyst 1 [1.0] 1 [1.0]
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 3
NTP Experiment-Test: 97013-94 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: 26-39 WEEKS WITH AVERAGE SEVERITY GRADES[b] Date: 12/08/03
Route: DOSED WATER WATER DISINFECTION MODEL (SODIUM BROMATE) Time: 14:45:56
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (6) (8) (8) (4)
Inflammation, Chronic Active 1 [1.0] 1 [3.0]
Epidermis, Hyperplasia, Focal 5 [2.4] 3 [3.0] 2 [3.0] 3 [1.7]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10)
Alveolar Epithelium, Hyperplasia 1 [1.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
Mineralization 1 [1.0] 2 [1.0]
Nephropathy 6 [1.0] 6 [1.0] 8 [1.3] 8 [1.3]
Cortex, Cyst 2 [1.0]
Glomerulus, Inflammation,
Membranoproliferative 1 [3.0] 2 [3.0] 1 [1.0]
Renal Tubule, Degeneration 7 [2.3]
Renal Tubule, Hypertrophy 2 [1.0] 5 [1.6]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 4
NTP Experiment-Test: 97013-94 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: 26-39 WEEKS WITH AVERAGE SEVERITY GRADES[b] Date: 12/08/03
Route: DOSED WATER WATER DISINFECTION MODEL (SODIUM BROMATE) Time: 14:45:56
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10
Early Deaths
Moribund Sacrifice 2 2 4 3
Natural Death 2 1 3
Survivors
Terminal Sacrifice 6 7 6 4
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10)
Hematopoietic Cell Proliferation 1 [1.0] 2 [1.5] 1 [1.0]
Inflammation, Chronic Active 5 [1.0] 5 [1.2] 7 [1.3] 4 [1.0]
Hepatocyte, Fatty Change 2 [1.5] 1 [1.0]
Hepatocyte, Necrosis 1 [1.0]
Hepatocyte, Vacuolization Cytoplasmic 5 [1.2] 6 [1.0] 6 [1.0] 3 [1.0]
Stomach, Forestomach (10) (10) (10) (10)
Epithelium, Hyperkeratosis 2 [2.0] 2 [2.0] 1 [2.0] 2 [2.0]
Epithelium, Hyperplasia 4 [2.0] 2 [2.0] 3 [2.0] 5 [2.0]
Epithelium, Hyperplasia, Focal 1 [2.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Hypertrophy 5 [2.2] 7 [2.0] 6 [1.3] 1 [1.0]
Pituitary Gland (10) (10) (10) (10)
Pars Distalis, Cyst 1 [1.0]
Pars Distalis, Hypertrophy 2 [1.5]
Thyroid Gland (10) (10) (10) (9)
Infiltration Cellular, Lymphocyte 4 [1.8]
Follicle, Cyst 1 [2.0]
Follicle, Depletion Secretory 3 [1.0] 4 [1.0] 4 [1.5] 7 [3.7]
Follicular Cell, Hypertrophy 6 [1.0] 8 [2.0] 8 [3.5]
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 5
NTP Experiment-Test: 97013-94 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: 26-39 WEEKS WITH AVERAGE SEVERITY GRADES[b] Date: 12/08/03
Route: DOSED WATER WATER DISINFECTION MODEL (SODIUM BROMATE) Time: 14:45:56
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (10) (10) (10) (10)
Cyst 1
Degeneration 1 [4.0] 1 [4.0] 7 [3.3]
Granuloma Sperm 1 [3.0]
Inflammation, Chronic Active 1 [2.0]
Preputial Gland (2) (3) (1)
Atrophy 1 [3.0] 1 [2.0]
Duct, Ectasia 2 [2.5] 2 [2.0] 1 [3.0]
Testes (10) (10) (10) (10)
Mineralization 1 [1.0]
Bilateral, Germinal Epithelium, Degeneration 3 [2.0] 8 [2.9]
Germinal Epithelium, Degeneration 1 [4.0] 1 [2.0] 2 [1.5]
Interstitial Cell, Hyperplasia 3 [1.3]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (9) (10) (10) (7)
Hyperplasia, Lymphoid 2 [2.5] 4 [3.3] 1 [3.0]
Lymph Node, Mesenteric (9) (10) (10) (9)
Hyperplasia, Lymphoid 1 [4.0]
Spleen (10) (10) (10) (10)
Atrophy 1 [3.0]
Hematopoietic Cell Proliferation 1 [3.0] 2 [2.5]
Thymus (10) (10) (9) (9)
Atrophy 5 [3.2] 1 [3.0] 3 [3.0] 6 [3.5]
Cyst 3 [1.3] 1 [1.0] 1 [2.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (9) (9) (9) (8)
Inflammation, Chronic Active 1 [3.0] 1 [1.0]
Epidermis, Hyperplasia, Focal 3 [2.0] 4 [2.5] 3 [2.3] 1 [2.0]
Hair Follicle, Sebaceous Gland, Atrophy 1 [1.0]
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 6
NTP Experiment-Test: 97013-94 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: 26-39 WEEKS WITH AVERAGE SEVERITY GRADES[b] Date: 12/08/03
Route: DOSED WATER WATER DISINFECTION MODEL (SODIUM BROMATE) Time: 14:45:56
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10)
Inflammation, Chronic Active 1 [1.0] 1 [2.0]
Thrombosis 1 [3.0]
Alveolar Epithelium, Hyperplasia 1 [4.0]
Alveolus, Infiltration Cellular, Histiocyte 1 [3.0]
Perivascular, Infiltration Cellular,
Lymphocyte 1 [2.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
Hydronephrosis 2 [2.0]
Inflammation 1 [2.0]
Mineralization 1 [2.0]
Nephropathy 7 [1.0] 6 [1.3] 7 [1.3] 10 [1.8]
Cortex, Cyst 1 [2.0] 1 [3.0]
Glomerulus, Inflammation,
Membranoproliferative 2 [3.5] 2 [2.0]
Renal Tubule, Degeneration 1 [3.0] 8 [3.0]
Renal Tubule, Hypertrophy 1 [1.0] 6 [1.3]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 7
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