TDMS Study 88138-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Battelle Columbus BENZOPHENONE DATE: 10/25/04
EXPERIMENT: 88138 TEST: 01 TIME: 13:30:25
TEST TYPE: SUBCHRON 90-DAY PAGE: 1
CONT: NO1-ES-15320 ROUTE: DOSED FEED NTP C#: C88138
PATHOLOGIST: YARRINGTON, J. YARRINGTON, JOHN CAS: 119-61-9
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Battelle Columbus BENZOPHENONE DATE: 10/25/04
EXPERIMENT: 88138 TEST: 01 TIME: 13:30:25
TEST TYPE: SUBCHRON 90-DAY
CONT: NO1-ES-15320 ROUTE: DOSED FEED NTP C#: C88138
PATHOLOGIST: YARRINGTON, J. YARRINGTON, JOHN CAS: 119-61-9
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF BENZOPHENONE
===============================================================
Male Rats
------------
Organ Morphology
----- ----------
Bone Marrow Atrophy
Heart: Myocardium Inflammation Chronic
Kidney Inflammation Chronic
Mineralization
Kidney: Papilla Necrosis
Kidney: Renal Tubule Casts Protein
Dilatation
Regeneration
Liver: Bile Duct Hyperplasia
Liver: Hepatocyte Hypertrophy
Vacuolization Cytoplasmic
Lung Inflammation Chronic
Preputial Gland Inflammation Chronic
Seminal Vesicle Atrophy
Testes: Germinal Epithelium Degeneration
===============================================================
Female Rats
------------
Organ Morphology
----- ----------
Bone Marrow Atrophy
Clitoral Gland Inflammation Chronic
Kidney: Papilla Necrosis
Kidney: Renal Tubule Casts Protein
Dilatation
Regeneration
Liver Inflammation Chronic
Inflammation Granulomatous
Liver: Hepatocyte Hypertrophy
Vacuolization Cytoplasmic
Lung Inflammation Chronic
Ovary: Periovarian Tissue Cyst
===============================================================
Date: 10/25/04 EXPERIMENT: 88138 TEST: 01 Page 1
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - BENZOPHENONE
Terminal Sacrifice at 14 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0% 0.125% 0.25% 0.5% 1.0% 2.0% |
| | |
|=================================================================================================================================|
| |
|Bone Marrow |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 10/10 (100%) |
|POLY-3 RATE (b) | 0/10.00 0/10.00 0/10.00 0/10.00 0/10.00 10/10.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 100.0% |
|TERMINAL (d) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- 40 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) (e) P<0.001 ** |
|POLY 3 | P<0.001 ** (e) (e) (e) (e) P<0.001N** |
|POLY 1.5 | P<0.001 ** (e) (e) (e) (e) P<0.001N** |
|POLY 6 | P<0.001 ** (e) (e) (e) (e) P<0.001N** |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) (e) (e) P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0% 0.125% 0.25% 0.5% 1.0% 2.0% |
| | |
|=================================================================================================================================|
| |
|Bone Marrow |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 2/10 (20%) 10/10 (100%) |
|POLY-3 RATE (b) | 0/10.00 0/10.00 0/10.00 0/10.00 2/10.00 10/10.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 20.0% 100.0% |
|TERMINAL (d) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 2/10 (20%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- 92 (T) 12 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) P=0.234 P<0.001 ** |
|POLY 3 | P<0.001 ** (e) (e) (e) P=0.227 P<0.001 ** |
|POLY 1.5 | P<0.001 ** (e) (e) (e) P=0.227 P<0.001 ** |
|POLY 6 | P<0.001 ** (e) (e) (e) P=0.227 P<0.001 ** |
|LOGISTIC REGRESSION| (e) (e) (e) (e) P=0.234 (e) |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) (e) P=0.237 P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/25/04 EXPERIMENT: 88138 TEST: 01 Page 2
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - BENZOPHENONE
Terminal Sacrifice at 14 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0% 0.125% 0.25% 0.5% 1.0% 2.0% |
| | |
|=================================================================================================================================|
| |
|Clitoral Gland |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | |
|POLY-3 RATE (b) | |
|POLY-3 PERCENT (g) | |
|TERMINAL (d) | |
|FIRST INCIDENCE | |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | |
|POLY 3 | |
|POLY 1.5 | |
|POLY 6 | |
|LOGISTIC REGRESSION| |
|COCH-ARM / FISHERS | |
|ORDER RESTRICTED | |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0% 0.125% 0.25% 0.5% 1.0% 2.0% |
| | |
|=================================================================================================================================|
| |
|Clitoral Gland |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 4/10 (40%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 4/10 (40%) 0/9 (0%) |
|POLY-3 RATE (b) | 4/10.00 0/0.00 0/0.00 0/0.00 4/10.00 0/0.69 |
|POLY-3 PERCENT (g) | 40.0% 0.0% 0.0% 0.0% 40.0% 0.0% |
|TERMINAL (d) | 4/10 (40%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 4/10 (40%) 0/0 (0%) |
|FIRST INCIDENCE | 92 (T) --- --- --- 92 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.672 P=1.000N P=1.000 P=1.000 P=0.672 P=1.000N |
|POLY 3 | (e) (e) (e) (e) P=0.667 P=0.591N |
|POLY 1.5 | (e) (e) (e) (e) P=0.667 P=0.376N |
|POLY 6 | (e) (e) (e) (e) P=0.667 P=0.665N |
|LOGISTIC REGRESSION| P=0.672 (e) (e) (e) P=0.672 (e) |
|COCH-ARM / FISHERS | P=0.049N* P=1.000 P=1.000 P=1.000 P=0.675N P=0.054N |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/25/04 EXPERIMENT: 88138 TEST: 01 Page 3
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - BENZOPHENONE
Terminal Sacrifice at 14 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0% 0.125% 0.25% 0.5% 1.0% 2.0% |
| | |
|=================================================================================================================================|
| |
|Heart: Myocardium |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 6/10 (60%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 3/10 (30%) 0/10 (0%) |
|POLY-3 RATE (b) | 6/10.00 0/0.00 0/0.00 0/0.00 3/10.00 0/0.82 |
|POLY-3 PERCENT (g) | 60.0% 0.0% 0.0% 0.0% 30.0% 0.0% |
|TERMINAL (d) | 6/10 (60%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 3/10 (30%) 0/0 (0%) |
|FIRST INCIDENCE | 92 (T) --- --- --- 92 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.190N P=1.000N P=1.000N P=1.000N P=0.190N P=1.000N |
|POLY 3 | (e) (e) (e) (e) P=0.186N P=0.517N |
|POLY 1.5 | (e) (e) (e) (e) P=0.186N P=0.185N |
|POLY 6 | (e) (e) (e) (e) P=0.186N P=0.656N |
|LOGISTIC REGRESSION| P=0.190N (e) (e) (e) P=0.190N (e) |
|COCH-ARM / FISHERS | P=0.004N** P=1.000 P=1.000 P=1.000 P=0.185N P=0.005N** |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0% 0.125% 0.25% 0.5% 1.0% 2.0% |
| | |
|=================================================================================================================================|
| |
|Heart: Myocardium |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 1/10 (10%) 1/9 (11%) |
|POLY-3 RATE (b) | 0/10.00 0/0.00 0/0.00 0/0.00 1/10.00 1/1.61 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 10.0% 62.1% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 1/10 (10%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- 92 (T) 39 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.050 (e) (e) (e) P=0.500 P=0.479 |
|POLY 3 | (e) (e) (e) (e) P=0.500 P=0.256 |
|POLY 1.5 | (e) (e) (e) (e) P=0.500 P=0.310 |
|POLY 6 | (e) (e) (e) (e) P=0.500 P=0.238 |
|LOGISTIC REGRESSION| P=0.500 (e) (e) (e) P=0.500 (e) |
|COCH-ARM / FISHERS | P=0.303 (e) (e) (e) P=0.500 P=0.474 |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/25/04 EXPERIMENT: 88138 TEST: 01 Page 4
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - BENZOPHENONE
Terminal Sacrifice at 14 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0% 0.125% 0.25% 0.5% 1.0% 2.0% |
| | |
|=================================================================================================================================|
| |
|Kidney |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 2/10 (20%) 3/10 (30%) 4/10 (40%) 2/10 (20%) 0/10 (0%) |
|POLY-3 RATE (b) | 0/10.00 2/10.00 3/10.00 4/10.00 2/10.00 0/0.82 |
|POLY-3 PERCENT (g) | 0.0% 20.0% 30.0% 40.0% 20.0% 0.0% |
|TERMINAL (d) | 0/10 (0%) 2/10 (20%) 3/10 (30%) 4/10 (40%) 2/10 (20%) 0/0 (0%) |
|FIRST INCIDENCE | --- 92 (T) 92 (T) 92 (T) 92 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.360 P=0.234 P=0.111 P=0.051 P=0.234 (e) |
|POLY 3 | P=0.265 P=0.227 P=0.095 P=0.033 * P=0.227 (e) |
|POLY 1.5 | P=0.379 P=0.227 P=0.095 P=0.033 * P=0.227 (e) |
|POLY 6 | P=0.254 P=0.227 P=0.095 P=0.033 * P=0.227 (e) |
|LOGISTIC REGRESSION| (e) P=0.234 P=0.111 P=0.051 P=0.234 (e) |
|COCH-ARM / FISHERS | P=0.218N P=0.237 P=0.105 P=0.043 * P=0.237 (e) |
|ORDER RESTRICTED | P=0.732 (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0% 0.125% 0.25% 0.5% 1.0% 2.0% |
| | |
|=================================================================================================================================|
| |
|Kidney |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/10 (20%) 2/10 (20%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|POLY-3 RATE (b) | 2/10.00 2/10.00 0/10.00 0/10.00 0/10.00 0/0.69 |
|POLY-3 PERCENT (g) | 20.0% 20.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/10 (20%) 2/10 (20%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 92 (T) 92 (T) --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.137N P=0.707 P=0.234N P=0.234N P=0.234N P=1.000N |
|POLY 3 | P=0.052N P=0.702 P=0.227N P=0.227N P=0.227N P=0.667N |
|POLY 1.5 | P=0.059N P=0.702 P=0.227N P=0.227N P=0.227N P=0.553N |
|POLY 6 | P=0.052N P=0.702 P=0.227N P=0.227N P=0.227N P=0.704N |
|LOGISTIC REGRESSION| P=0.137N P=0.707 (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.089N P=0.709N P=0.237N P=0.237N P=0.237N P=0.263N |
|ORDER RESTRICTED | P=0.745N (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/25/04 EXPERIMENT: 88138 TEST: 01 Page 5
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - BENZOPHENONE
Terminal Sacrifice at 14 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0% 0.125% 0.25% 0.5% 1.0% 2.0% |
| | |
|=================================================================================================================================|
| |
|Kidney |
| Mineralization |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 5/10 (50%) 10/10 (100%) 0/10 (0%) |
|POLY-3 RATE (b) | 0/10.00 0/10.00 0/10.00 5/10.00 10/10.00 0/0.82 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 50.0% 100.0% 0.0% |
|TERMINAL (d) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 5/10 (50%) 10/10 (100%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- 92 (T) 92 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) P=0.022 * P<0.001 ** (e) |
|POLY 3 | P<0.001 ** (e) (e) P=0.008 ** P<0.001 ** (e) |
|POLY 1.5 | P<0.001 ** (e) (e) P=0.008 ** P<0.001 ** (e) |
|POLY 6 | P<0.001 ** (e) (e) P=0.008 ** P<0.001 ** (e) |
|LOGISTIC REGRESSION| (e) (e) (e) P=0.022 * P<0.001 ** (e) |
|COCH-ARM / FISHERS | P=0.158 (e) (e) P=0.016 * P<0.001 ** (e) |
|ORDER RESTRICTED | P=0.233 (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0% 0.125% 0.25% 0.5% 1.0% 2.0% |
| | |
|=================================================================================================================================|
| |
|Kidney |
| Mineralization |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 10/10 (100%) 10/10 (100%) 10/10 (100%) 10/10 (100%) 10/10 (100%) 9/9 (100%) |
|POLY-3 RATE (b) | 10/10.00 10/10.00 10/10.00 10/10.00 10/10.00 9/9.00 |
|POLY-3 PERCENT (g) | 100.0% 100.0% 100.0% 100.0% 100.0% 100.0% |
|TERMINAL (d) | 10/10 (100%) 10/10 (100%) 10/10 (100%) 10/10 (100%) 10/10 (100%) 0/0 (0%) |
|FIRST INCIDENCE | 92 (T) 92 (T) 92 (T) 92 (T) 92 (T) 39 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) (e) |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/25/04 EXPERIMENT: 88138 TEST: 01 Page 6
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - BENZOPHENONE
Terminal Sacrifice at 14 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0% 0.125% 0.25% 0.5% 1.0% 2.0% |
| | |
|=================================================================================================================================|
| |
|Kidney: Papilla |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 2/10 (20%) 6/10 (60%) |
|POLY-3 RATE (b) | 0/10.00 0/10.00 0/10.00 0/10.00 2/10.00 6/6.33 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 20.0% 94.8% |
|TERMINAL (d) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 2/10 (20%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- 92 (T) 40 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) P=0.234 P=0.009 ** |
|POLY 3 | P<0.001 ** (e) (e) (e) P=0.227 P<0.001 ** |
|POLY 1.5 | P<0.001 ** (e) (e) (e) P=0.227 P<0.001 ** |
|POLY 6 | P<0.001 ** (e) (e) (e) P=0.227 P<0.001 ** |
|LOGISTIC REGRESSION| P=0.063 (e) (e) (e) P=0.234 (e) |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) (e) P=0.237 P=0.005 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0% 0.125% 0.25% 0.5% 1.0% 2.0% |
| | |
|=================================================================================================================================|
| |
|Kidney: Papilla |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 3/9 (33%) |
|POLY-3 RATE (b) | 0/10.00 0/10.00 0/10.00 0/10.00 0/10.00 3/3.46 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 86.8% |
|TERMINAL (d) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- 39 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) (e) P=0.093 |
|POLY 3 | P=0.003 ** (e) (e) (e) (e) P=0.004 ** |
|POLY 1.5 | P<0.001 ** (e) (e) (e) (e) P=0.010 * |
|POLY 6 | P=0.006 ** (e) (e) (e) (e) P=0.002 ** |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) (e) (e) P=0.087 |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/25/04 EXPERIMENT: 88138 TEST: 01 Page 7
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - BENZOPHENONE
Terminal Sacrifice at 14 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0% 0.125% 0.25% 0.5% 1.0% 2.0% |
| | |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Casts Protein |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 8/10 (80%) 8/10 (80%) 9/10 (90%) 10/10 (100%) 0/10 (0%) |
|POLY-3 RATE (b) | 0/10.00 8/10.00 8/10.00 9/10.00 10/10.00 0/0.82 |
|POLY-3 PERCENT (g) | 0.0% 80.0% 80.0% 90.0% 100.0% 0.0% |
|TERMINAL (d) | 0/10 (0%) 8/10 (80%) 8/10 (80%) 9/10 (90%) 10/10 (100%) 0/0 (0%) |
|FIRST INCIDENCE | --- 92 (T) 92 (T) 92 (T) 92 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** (e) |
|POLY 3 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** (e) |
|POLY 1.5 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** (e) |
|POLY 6 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** (e) |
|LOGISTIC REGRESSION| (e) P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** (e) |
|COCH-ARM / FISHERS | P=0.039N* P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** (e) |
|ORDER RESTRICTED | P=0.347 (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0% 0.125% 0.25% 0.5% 1.0% 2.0% |
| | |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Casts Protein |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/10 (0%) 2/10 (20%) 0/10 (0%) 4/10 (40%) 0/9 (0%) |
|POLY-3 RATE (b) | 0/10.00 0/10.00 2/10.00 0/10.00 4/10.00 0/0.69 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 20.0% 0.0% 40.0% 0.0% |
|TERMINAL (d) | 0/10 (0%) 0/10 (0%) 2/10 (20%) 0/10 (0%) 4/10 (40%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- 92 (T) --- 92 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.016 * (e) P=0.234 (e) P=0.051 (e) |
|POLY 3 | P=0.002 ** (e) P=0.227 (e) P=0.033 * (e) |
|POLY 1.5 | P=0.008 ** (e) P=0.227 (e) P=0.033 * (e) |
|POLY 6 | P=0.002 ** (e) P=0.227 (e) P=0.033 * (e) |
|LOGISTIC REGRESSION| (e) (e) P=0.234 (e) P=0.051 (e) |
|COCH-ARM / FISHERS | P=0.433 (e) P=0.237 (e) P=0.043 * (e) |
|ORDER RESTRICTED | P=0.679 (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/25/04 EXPERIMENT: 88138 TEST: 01 Page 8
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - BENZOPHENONE
Terminal Sacrifice at 14 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0% 0.125% 0.25% 0.5% 1.0% 2.0% |
| | |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Dilatation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/10 (0%) 6/10 (60%) 8/10 (80%) 9/10 (90%) 8/10 (80%) |
|POLY-3 RATE (b) | 0/10.00 0/10.00 6/10.00 8/10.00 9/10.00 8/8.16 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 60.0% 80.0% 90.0% 98.0% |
|TERMINAL (d) | 0/10 (0%) 0/10 (0%) 6/10 (60%) 8/10 (80%) 9/10 (90%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- 92 (T) 92 (T) 92 (T) 40 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) P=0.009 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 3 | P<0.001 ** (e) P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** (e) P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 6 | P<0.001 ** (e) P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** (e) P=0.009 ** P<0.001 ** P<0.001 ** (e) |
|COCH-ARM / FISHERS | P<0.001 ** (e) P=0.005 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0% 0.125% 0.25% 0.5% 1.0% 2.0% |
| | |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Dilatation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 3/10 (30%) 5/9 (56%) |
|POLY-3 RATE (b) | 0/10.00 0/10.00 0/10.00 0/10.00 3/10.00 5/5.31 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 30.0% 94.3% |
|TERMINAL (d) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 3/10 (30%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- 92 (T) 39 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) P=0.111 P=0.015 * |
|POLY 3 | P<0.001 ** (e) (e) (e) P=0.095 P<0.001 ** |
|POLY 1.5 | P<0.001 ** (e) (e) (e) P=0.095 P<0.001 ** |
|POLY 6 | P<0.001 ** (e) (e) (e) P=0.095 P<0.001 ** |
|LOGISTIC REGRESSION| P=0.010 * (e) (e) (e) P=0.111 (e) |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) (e) P=0.105 P=0.011 * |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/25/04 EXPERIMENT: 88138 TEST: 01 Page 9
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - BENZOPHENONE
Terminal Sacrifice at 14 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0% 0.125% 0.25% 0.5% 1.0% 2.0% |
| | |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Regeneration |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 10/10 (100%) 10/10 (100%) 10/10 (100%) 10/10 (100%) 10/10 (100%) 8/10 (80%) |
|POLY-3 RATE (b) | 10/10.00 10/10.00 10/10.00 10/10.00 10/10.00 8/8.16 |
|POLY-3 PERCENT (g) | 100.0% 100.0% 100.0% 100.0% 100.0% 98.0% |
|TERMINAL (d) | 10/10 (100%) 10/10 (100%) 10/10 (100%) 10/10 (100%) 10/10 (100%) 0/0 (0%) |
|FIRST INCIDENCE | 92 (T) 92 (T) 92 (T) 92 (T) 92 (T) 40 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) (e) P<0.001 ** |
|POLY 3 | P=0.995N (e) (e) (e) (e) P=1.000N |
|POLY 1.5 | P=0.111N (e) (e) (e) (e) P=0.823N |
|POLY 6 | P=1.000N (e) (e) (e) (e) P=1.000N |
|LOGISTIC REGRESSION| P<0.001 ** (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.010N* (e) (e) (e) (e) P=0.237N |
|ORDER RESTRICTED | P=0.004N** (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0% 0.125% 0.25% 0.5% 1.0% 2.0% |
| | |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Regeneration |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/10 (30%) 8/10 (80%) 6/10 (60%) 6/10 (60%) 9/10 (90%) 7/9 (78%) |
|POLY-3 RATE (b) | 3/10.00 8/10.00 6/10.00 6/10.00 9/10.00 7/7.15 |
|POLY-3 PERCENT (g) | 30.0% 80.0% 60.0% 60.0% 90.0% 97.9% |
|TERMINAL (d) | 3/10 (30%) 8/10 (80%) 6/10 (60%) 6/10 (60%) 9/10 (90%) 0/0 (0%) |
|FIRST INCIDENCE | 92 (T) 92 (T) 92 (T) 92 (T) 92 (T) 39 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** P=0.040 * P=0.190 P=0.190 P=0.013 * P=0.002 ** |
|POLY 3 | P=0.004 ** P=0.024 * P=0.186 P=0.186 P=0.003 ** P=0.002 ** |
|POLY 1.5 | P=0.008 ** P=0.024 * P=0.186 P=0.186 P=0.003 ** P=0.005 ** |
|POLY 6 | P=0.003 ** P=0.024 * P=0.186 P=0.186 P=0.003 ** P=0.002 ** |
|LOGISTIC REGRESSION| P=0.048 * P=0.040 * P=0.190 P=0.190 P=0.013 * (e) |
|COCH-ARM / FISHERS | P=0.064 P=0.035 * P=0.185 P=0.185 P=0.010 * P=0.051 |
|ORDER RESTRICTED | P=0.002 ** (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/25/04 EXPERIMENT: 88138 TEST: 01 Page 10
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - BENZOPHENONE
Terminal Sacrifice at 14 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0% 0.125% 0.25% 0.5% 1.0% 2.0% |
| | |
|=================================================================================================================================|
| |
|Liver |
| Hepatodiaphragmatic Nodule |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/10 (10%) 2/10 (20%) 3/10 (30%) 2/10 (20%) 1/10 (10%) 1/10 (10%) |
|POLY-3 RATE (b) | 1/10.00 2/10.00 3/10.00 2/10.00 1/10.00 1/1.74 |
|POLY-3 PERCENT (g) | 10.0% 20.0% 30.0% 20.0% 10.0% 57.5% |
|TERMINAL (d) | 1/10 (10%) 2/10 (20%) 3/10 (30%) 2/10 (20%) 1/10 (10%) 0/0 (0%) |
|FIRST INCIDENCE | 92 (T) 92 (T) 92 (T) 92 (T) 92 (T) 40 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.343 P=0.500 P=0.293 P=0.500 P=0.766 P=0.500 |
|POLY 3 | P=0.527N P=0.500 P=0.292 P=0.500 P=0.760 P=0.400 |
|POLY 1.5 | P=0.526N P=0.500 P=0.292 P=0.500 P=0.760 P=0.515 |
|POLY 6 | P=0.506N P=0.500 P=0.292 P=0.500 P=0.760 P=0.355 |
|LOGISTIC REGRESSION| P=0.552N P=0.500 P=0.293 P=0.500 P=0.766 (e) |
|COCH-ARM / FISHERS | P=0.314N P=0.500 P=0.291 P=0.500 P=0.763N P=0.763N |
|ORDER RESTRICTED | P=0.453 (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0% 0.125% 0.25% 0.5% 1.0% 2.0% |
| | |
|=================================================================================================================================|
| |
|Liver |
| Hepatodiaphragmatic Nodule |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/10 (10%) 4/10 (40%) 2/10 (20%) 3/10 (30%) 1/10 (10%) 2/9 (22%) |
|POLY-3 RATE (b) | 1/10.00 4/10.00 2/10.00 3/10.00 1/10.00 2/2.53 |
|POLY-3 PERCENT (g) | 10.0% 40.0% 20.0% 30.0% 10.0% 79.0% |
|TERMINAL (d) | 1/10 (10%) 4/10 (40%) 2/10 (20%) 3/10 (30%) 1/10 (10%) 0/0 (0%) |
|FIRST INCIDENCE | 92 (T) 92 (T) 92 (T) 92 (T) 92 (T) 39 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.123 P=0.157 P=0.500 P=0.293 P=0.766 P=0.210 |
|POLY 3 | P=0.577 P=0.148 P=0.500 P=0.292 P=0.760 P=0.137 |
|POLY 1.5 | P=0.529 P=0.148 P=0.500 P=0.292 P=0.760 P=0.207 |
|POLY 6 | P=0.568N P=0.148 P=0.500 P=0.292 P=0.760 P=0.115 |
|LOGISTIC REGRESSION| P=0.452N P=0.157 P=0.500 P=0.293 P=0.766 (e) |
|COCH-ARM / FISHERS | P=0.482N P=0.152 P=0.500 P=0.291 P=0.763N P=0.458 |
|ORDER RESTRICTED | P=0.157 (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/25/04 EXPERIMENT: 88138 TEST: 01 Page 11
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - BENZOPHENONE
Terminal Sacrifice at 14 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0% 0.125% 0.25% 0.5% 1.0% 2.0% |
| | |
|=================================================================================================================================|
| |
|Liver |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/10 (0%) |
|POLY-3 RATE (b) | 0/10.00 0/10.00 0/10.00 0/10.00 1/10.00 0/0.82 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 10.0% 0.0% |
|TERMINAL (d) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- 92 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.362 (e) (e) (e) P=0.500 (e) |
|POLY 3 | P=0.127 (e) (e) (e) P=0.500 (e) |
|POLY 1.5 | P=0.175 (e) (e) (e) P=0.500 (e) |
|POLY 6 | P=0.123 (e) (e) (e) P=0.500 (e) |
|LOGISTIC REGRESSION| P=0.360 (e) (e) (e) P=0.500 (e) |
|COCH-ARM / FISHERS | P=0.585 (e) (e) (e) P=0.500 (e) |
|ORDER RESTRICTED | P=0.741 (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0% 0.125% 0.25% 0.5% 1.0% 2.0% |
| | |
|=================================================================================================================================|
| |
|Liver |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/10 (30%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|POLY-3 RATE (b) | 3/10.00 0/10.00 0/10.00 0/10.00 0/10.00 0/0.69 |
|POLY-3 PERCENT (g) | 30.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 3/10 (30%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 92 (T) --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.149N P=0.111N P=0.111N P=0.111N P=0.111N P=1.000N |
|POLY 3 | P=0.040N* P=0.095N P=0.095N P=0.095N P=0.095N P=0.622N |
|POLY 1.5 | P=0.048N* P=0.095N P=0.095N P=0.095N P=0.095N P=0.456N |
|POLY 6 | P=0.039N* P=0.095N P=0.095N P=0.095N P=0.095N P=0.678N |
|LOGISTIC REGRESSION| P=0.149N (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.113N P=0.105N P=0.105N P=0.105N P=0.105N P=0.124N |
|ORDER RESTRICTED | P=0.661N (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/25/04 EXPERIMENT: 88138 TEST: 01 Page 12
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - BENZOPHENONE
Terminal Sacrifice at 14 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0% 0.125% 0.25% 0.5% 1.0% 2.0% |
| | |
|=================================================================================================================================|
| |
|Liver |
| Inflammation Granulomatous |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|POLY-3 RATE (b) | 0/10.00 0/10.00 0/10.00 0/10.00 0/10.00 0/0.82 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) (e) |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0% 0.125% 0.25% 0.5% 1.0% 2.0% |
| | |
|=================================================================================================================================|
| |
|Liver |
| Inflammation Granulomatous |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/10 (20%) 4/10 (40%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|POLY-3 RATE (b) | 2/10.00 4/10.00 0/10.00 0/10.00 0/10.00 0/0.69 |
|POLY-3 PERCENT (g) | 20.0% 40.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/10 (20%) 4/10 (40%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 92 (T) 92 (T) --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.064N P=0.317 P=0.234N P=0.234N P=0.234N P=1.000N |
|POLY 3 | P=0.015N* P=0.318 P=0.227N P=0.227N P=0.227N P=0.667N |
|POLY 1.5 | P=0.018N* P=0.318 P=0.227N P=0.227N P=0.227N P=0.553N |
|POLY 6 | P=0.014N* P=0.318 P=0.227N P=0.227N P=0.227N P=0.704N |
|LOGISTIC REGRESSION| P=0.064N P=0.317 (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.039N* P=0.314 P=0.237N P=0.237N P=0.237N P=0.263N |
|ORDER RESTRICTED | P=0.711N (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/25/04 EXPERIMENT: 88138 TEST: 01 Page 13
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - BENZOPHENONE
Terminal Sacrifice at 14 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0% 0.125% 0.25% 0.5% 1.0% 2.0% |
| | |
|=================================================================================================================================|
| |
|Liver: Bile Duct |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 9/10 (90%) |
|POLY-3 RATE (b) | 0/10.00 0/10.00 0/10.00 0/10.00 0/10.00 9/9.08 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 99.1% |
|TERMINAL (d) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- 40 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) (e) P<0.001 ** |
|POLY 3 | P<0.001 ** (e) (e) (e) (e) P<0.001 ** |
|POLY 1.5 | P<0.001 ** (e) (e) (e) (e) P<0.001 ** |
|POLY 6 | P<0.001 ** (e) (e) (e) (e) P<0.001 ** |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) (e) (e) P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0% 0.125% 0.25% 0.5% 1.0% 2.0% |
| | |
|=================================================================================================================================|
| |
|Liver: Bile Duct |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) |
|POLY-3 RATE (b) | 0/10.00 0/10.00 0/10.00 0/10.00 0/10.00 0/0.69 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) (e) |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/25/04 EXPERIMENT: 88138 TEST: 01 Page 14
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - BENZOPHENONE
Terminal Sacrifice at 14 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0% 0.125% 0.25% 0.5% 1.0% 2.0% |
| | |
|=================================================================================================================================|
| |
|Liver: Hepatocyte |
| Hypertrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 5/10 (50%) 7/10 (70%) |
|POLY-3 RATE (b) | 0/10.00 0/10.00 0/10.00 0/10.00 5/10.00 7/7.25 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 50.0% 96.6% |
|TERMINAL (d) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 5/10 (50%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- 92 (T) 40 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) P=0.022 * P=0.003 ** |
|POLY 3 | P<0.001 ** (e) (e) (e) P=0.008 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** (e) (e) (e) P=0.008 ** P<0.001 ** |
|POLY 6 | P<0.001 ** (e) (e) (e) P=0.008 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** (e) (e) (e) P=0.022 * (e) |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) (e) P=0.016 * P=0.002 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0% 0.125% 0.25% 0.5% 1.0% 2.0% |
| | |
|=================================================================================================================================|
| |
|Liver: Hepatocyte |
| Hypertrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 2/10 (20%) 8/10 (80%) 10/10 (100%) 10/10 (100%) 7/9 (78%) |
|POLY-3 RATE (b) | 0/10.00 2/10.00 8/10.00 10/10.00 10/10.00 7/7.15 |
|POLY-3 PERCENT (g) | 0.0% 20.0% 80.0% 100.0% 100.0% 97.9% |
|TERMINAL (d) | 0/10 (0%) 2/10 (20%) 8/10 (80%) 10/10 (100%) 10/10 (100%) 0/0 (0%) |
|FIRST INCIDENCE | --- 92 (T) 92 (T) 92 (T) 92 (T) 39 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** P=0.234 P<0.001 ** P<0.001 ** P<0.001 ** P=0.002 ** |
|POLY 3 | P<0.001 ** P=0.227 P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** P=0.227 P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 6 | P<0.001 ** P=0.227 P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** P=0.234 P<0.001 ** P<0.001 ** P<0.001 ** (e) |
|COCH-ARM / FISHERS | P<0.001 ** P=0.237 P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/25/04 EXPERIMENT: 88138 TEST: 01 Page 15
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - BENZOPHENONE
Terminal Sacrifice at 14 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0% 0.125% 0.25% 0.5% 1.0% 2.0% |
| | |
|=================================================================================================================================|
| |
|Liver: Hepatocyte |
| Vacuolization Cytoplasmic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/10 (10%) 10/10 (100%) 10/10 (100%) 10/10 (100%) 10/10 (100%) 10/10 (100%) |
|POLY-3 RATE (b) | 1/10.00 10/10.00 10/10.00 10/10.00 10/10.00 10/10.00 |
|POLY-3 PERCENT (g) | 10.0% 100.0% 100.0% 100.0% 100.0% 100.0% |
|TERMINAL (d) | 1/10 (10%) 10/10 (100%) 10/10 (100%) 10/10 (100%) 10/10 (100%) 0/0 (0%) |
|FIRST INCIDENCE | 92 (T) 92 (T) 92 (T) 92 (T) 92 (T) 40 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 3 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 6 | P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** (e) |
|COCH-ARM / FISHERS | P=0.003 ** P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0% 0.125% 0.25% 0.5% 1.0% 2.0% |
| | |
|=================================================================================================================================|
| |
|Liver: Hepatocyte |
| Vacuolization Cytoplasmic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 9/10 (90%) 10/10 (100%) 7/9 (78%) |
|POLY-3 RATE (b) | 0/10.00 0/10.00 0/10.00 9/10.00 10/10.00 7/7.15 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 90.0% 100.0% 97.9% |
|TERMINAL (d) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 9/10 (90%) 10/10 (100%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- 92 (T) 92 (T) 39 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) P<0.001 ** P<0.001 ** P=0.002 ** |
|POLY 3 | P<0.001 ** (e) (e) P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** (e) (e) P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 6 | P<0.001 ** (e) (e) P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** (e) (e) P<0.001 ** P<0.001 ** (e) |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) P<0.001 ** P<0.001 ** P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/25/04 EXPERIMENT: 88138 TEST: 01 Page 16
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - BENZOPHENONE
Terminal Sacrifice at 14 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0% 0.125% 0.25% 0.5% 1.0% 2.0% |
| | |
|=================================================================================================================================|
| |
|Lung |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/10 (10%) 0/0 (0%) 2/2 (100%) 3/3 (100%) 1/10 (10%) 5/10 (50%) |
|POLY-3 RATE (b) | 1/10.00 0/0.00 2/2.00 3/3.00 1/10.00 5/5.41 |
|POLY-3 PERCENT (g) | 10.0% 0.0% 100.0% 100.0% 10.0% 92.4% |
|TERMINAL (d) | 1/10 (10%) 0/0 (0%) 2/2 (100%) 3/3 (100%) 1/10 (10%) 0/0 (0%) |
|FIRST INCIDENCE | 92 (T) --- 92 (T) 92 (T) 92 (T) 40 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** P=1.000N P=0.043 * P=0.015 * P=0.766 P=0.022 * |
|POLY 3 | (e) (e) P=0.005 ** P<0.001 ** P=0.760 P<0.001 ** |
|POLY 1.5 | (e) (e) P=0.005 ** P<0.001 ** P=0.760 P=0.004 ** |
|POLY 6 | (e) (e) P=0.005 ** P<0.001 ** P=0.760 P<0.001 ** |
|LOGISTIC REGRESSION| P=0.555N (e) P=0.043 * P=0.015 * P=0.766 (e) |
|COCH-ARM / FISHERS | P=0.244 P=1.000 P=0.045 * P=0.014 * P=0.763N P=0.070 |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0% 0.125% 0.25% 0.5% 1.0% 2.0% |
| | |
|=================================================================================================================================|
| |
|Lung |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 1/1 (100%) 0/0 (0%) 5/5 (100%) 3/10 (30%) 6/9 (67%) |
|POLY-3 RATE (b) | 0/10.00 1/1.00 0/0.00 5/5.00 3/10.00 6/6.23 |
|POLY-3 PERCENT (g) | 0.0% 100.0% 0.0% 100.0% 30.0% 96.3% |
|TERMINAL (d) | 0/10 (0%) 1/1 (100%) 0/0 (0%) 5/5 (100%) 3/10 (30%) 0/0 (0%) |
|FIRST INCIDENCE | --- 92 (T) --- 92 (T) 92 (T) 39 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** P=0.077 (e) P<0.001 ** P=0.111 P=0.005 ** |
|POLY 3 | (e) P=0.091 (e) P<0.001N** P=0.095 P<0.001 ** |
|POLY 1.5 | (e) P=0.091 (e) P<0.001N** P=0.095 P<0.001 ** |
|POLY 6 | (e) P=0.091 (e) P<0.001N** P=0.095 P<0.001 ** |
|LOGISTIC REGRESSION| P=0.242 P=0.077 (e) P<0.001 ** P=0.111 (e) |
|COCH-ARM / FISHERS | P=0.037 * P=0.091 (e) P<0.001 ** P=0.105 P=0.003 ** |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/25/04 EXPERIMENT: 88138 TEST: 01 Page 17
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - BENZOPHENONE
Terminal Sacrifice at 14 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0% 0.125% 0.25% 0.5% 1.0% 2.0% |
| | |
|=================================================================================================================================|
| |
|Ovary: Periovarian Tissue |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | |
|POLY-3 RATE (b) | |
|POLY-3 PERCENT (g) | |
|TERMINAL (d) | |
|FIRST INCIDENCE | |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | |
|POLY 3 | |
|POLY 1.5 | |
|POLY 6 | |
|LOGISTIC REGRESSION| |
|COCH-ARM / FISHERS | |
|ORDER RESTRICTED | |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0% 0.125% 0.25% 0.5% 1.0% 2.0% |
| | |
|=================================================================================================================================|
| |
|Ovary: Periovarian Tissue |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/10 (30%) 2/2 (100%) 1/1 (100%) 0/0 (0%) 0/10 (0%) 0/9 (0%) |
|POLY-3 RATE (b) | 3/10.00 2/2.00 1/1.00 0/0.00 0/10.00 0/0.69 |
|POLY-3 PERCENT (g) | 30.0% 100.0% 100.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 3/10 (30%) 2/2 (100%) 1/1 (100%) 0/0 (0%) 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 92 (T) 92 (T) 92 (T) --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.046N* P=0.158 P=0.388 P=1.000N P=0.111N P=1.000N |
|POLY 3 | (e) P=0.130 P=0.384 (e) P=0.095N P=0.622N |
|POLY 1.5 | (e) P=0.130 P=0.384 (e) P=0.095N P=0.456N |
|POLY 6 | (e) P=0.130 P=0.384 (e) P=0.095N P=0.678N |
|LOGISTIC REGRESSION| P=0.046N* P=0.158 P=0.388 (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.007N** P=0.152 P=0.364 P=1.000 P=0.105N P=0.124N |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/25/04 EXPERIMENT: 88138 TEST: 01 Page 18
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - BENZOPHENONE
Terminal Sacrifice at 14 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0% 0.125% 0.25% 0.5% 1.0% 2.0% |
| | |
|=================================================================================================================================|
| |
|Preputial Gland |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/10 (20%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 6/10 (60%) 4/10 (40%) |
|POLY-3 RATE (b) | 2/10.00 0/0.00 0/0.00 0/0.00 6/10.00 4/4.49 |
|POLY-3 PERCENT (g) | 20.0% 0.0% 0.0% 0.0% 60.0% 89.0% |
|TERMINAL (d) | 2/10 (20%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 6/10 (60%) 0/0 (0%) |
|FIRST INCIDENCE | 92 (T) --- --- --- 92 (T) 40 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** P=1.000N P=1.000N P=1.000N P=0.091 P=0.051 |
|POLY 3 | (e) (e) (e) (e) P=0.077 P=0.034 * |
|POLY 1.5 | (e) (e) (e) (e) P=0.077 P=0.077 |
|POLY 6 | (e) (e) (e) (e) P=0.077 P=0.023 * |
|LOGISTIC REGRESSION| P=0.085 (e) (e) (e) P=0.091 (e) |
|COCH-ARM / FISHERS | P=0.247 P=1.000 P=1.000 P=1.000 P=0.085 P=0.314 |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0% 0.125% 0.25% 0.5% 1.0% 2.0% |
| | |
|=================================================================================================================================|
| |
|Preputial Gland |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | |
|POLY-3 RATE (b) | |
|POLY-3 PERCENT (g) | |
|TERMINAL (d) | |
|FIRST INCIDENCE | |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | |
|POLY 3 | |
|POLY 1.5 | |
|POLY 6 | |
|LOGISTIC REGRESSION| |
|COCH-ARM / FISHERS | |
|ORDER RESTRICTED | |
|=================================================================================================================================|
Date: 10/25/04 EXPERIMENT: 88138 TEST: 01 Page 19
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - BENZOPHENONE
Terminal Sacrifice at 14 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0% 0.125% 0.25% 0.5% 1.0% 2.0% |
| | |
|=================================================================================================================================|
| |
|Seminal Vesicle |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) 3/9 (33%) |
|POLY-3 RATE (b) | 0/10.00 0/0.00 0/0.00 0/0.00 0/10.00 3/3.49 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 85.9% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- 40 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) (e) P=0.093 |
|POLY 3 | (e) (e) (e) (e) (e) P=0.004 ** |
|POLY 1.5 | (e) (e) (e) (e) (e) P=0.011 * |
|POLY 6 | (e) (e) (e) (e) (e) P=0.002 ** |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.025 * (e) (e) (e) (e) P=0.087 |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0% 0.125% 0.25% 0.5% 1.0% 2.0% |
| | |
|=================================================================================================================================|
| |
|Seminal Vesicle |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | |
|POLY-3 RATE (b) | |
|POLY-3 PERCENT (g) | |
|TERMINAL (d) | |
|FIRST INCIDENCE | |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | |
|POLY 3 | |
|POLY 1.5 | |
|POLY 6 | |
|LOGISTIC REGRESSION| |
|COCH-ARM / FISHERS | |
|ORDER RESTRICTED | |
|=================================================================================================================================|
Date: 10/25/04 EXPERIMENT: 88138 TEST: 01 Page 20
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - BENZOPHENONE
Terminal Sacrifice at 14 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0% 0.125% 0.25% 0.5% 1.0% 2.0% |
| | |
|=================================================================================================================================|
| |
|Testes: Germinal Epithelium |
| Degeneration |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 10/10 (100%) |
|POLY-3 RATE (b) | 0/10.00 0/10.00 0/10.00 0/10.00 0/10.00 10/10.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 100.0% |
|TERMINAL (d) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- 40 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) (e) P<0.001 ** |
|POLY 3 | P<0.001 ** (e) (e) (e) (e) P<0.001 ** |
|POLY 1.5 | P<0.001 ** (e) (e) (e) (e) P<0.001 ** |
|POLY 6 | P<0.001 ** (e) (e) (e) (e) P<0.001 ** |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) (e) (e) P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0% 0.125% 0.25% 0.5% 1.0% 2.0% |
| | |
|=================================================================================================================================|
| |
|Testes: Germinal Epithelium |
| Degeneration |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | |
|POLY-3 RATE (b) | |
|POLY-3 PERCENT (g) | |
|TERMINAL (d) | |
|FIRST INCIDENCE | |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | |
|POLY 3 | |
|POLY 1.5 | |
|POLY 6 | |
|LOGISTIC REGRESSION| |
|COCH-ARM / FISHERS | |
|ORDER RESTRICTED | |
|=================================================================================================================================|
Date: 10/25/04 EXPERIMENT: 88138 TEST: 01 Page 21
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - BENZOPHENONE
Terminal Sacrifice at 14 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0% 0.125% 0.25% 0.5% 1.0% 2.0% |
| | |
|=================================================================================================================================|
| |
|Thyroid Gland |
| Ultimobranchial Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) 0/10 (0%) |
|POLY-3 RATE (b) | 0/10.00 0/0.00 0/0.00 0/0.00 0/10.00 0/0.82 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) (e) |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0% 0.125% 0.25% 0.5% 1.0% 2.0% |
| | |
|=================================================================================================================================|
| |
|Thyroid Gland |
| Ultimobranchial Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 2/10 (20%) 0/9 (0%) |
|POLY-3 RATE (b) | 0/10.00 0/0.00 0/0.00 0/0.00 2/10.00 0/0.69 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 20.0% 0.0% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 2/10 (20%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- 92 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.234 (e) (e) (e) P=0.234 (e) |
|POLY 3 | (e) (e) (e) (e) P=0.227 (e) |
|POLY 1.5 | (e) (e) (e) (e) P=0.227 (e) |
|POLY 6 | (e) (e) (e) (e) P=0.227 (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) P=0.234 (e) |
|COCH-ARM / FISHERS | P=0.652 (e) (e) (e) P=0.237 (e) |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/25/04 EXPERIMENT: 88138 TEST: 01 Page 22
Statistical Analysis of Non-neoplastic Lesions in Rats(FISCHER 344) - BENZOPHENONE
Terminal Sacrifice at 14 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | 0% 0.125% 0.25% 0.5% 1.0% 2.0% |
| | |
|=================================================================================================================================|
| |
|Ureter: Transitional Epithelium |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 2/2 (100%) |
|POLY-3 RATE (b) | 0/0.00 0/0.00 0/0.00 0/0.00 0/0.00 2/2.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 100.0% |
|TERMINAL (d) | 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- 40 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) (e) |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0% 0.125% 0.25% 0.5% 1.0% 2.0% |
| | |
|=================================================================================================================================|
| |
|Ureter: Transitional Epithelium |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |
|POLY-3 RATE (b) | 0/0.00 0/0.00 0/0.00 0/0.00 0/0.00 0/0.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) (e) |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Number of tumor-bearing animals / Poly-3 number
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death.
Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e) Value of Statistic cannot be computed.
(g) Poly-3 adjusted lifetime tumor incidence.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).