TDMS Study 92013-06 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst 4-METHYLIMIDAZOLE DATE: 01/12/04
EXPERIMENT: 92013 TEST: 06 TIME: 14:45:36
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-85420 ROUTE: DOSED FEED NTP C#: 92013B
PATHOLOGIST: HEATH, JAMES CAS: 822-36-6
------------------------------------------------------------------------------------------------------------------------------------
FINAL #1 MICE
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst 4-METHYLIMIDAZOLE DATE: 01/12/04
EXPERIMENT: 92013 TEST: 06 TIME: 14:45:36
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-85420 ROUTE: DOSED FEED NTP C#: 92013B
PATHOLOGIST: HEATH, JAMES CAS: 822-36-6
4-METHYLIMIDAZOLE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 5 CENSORED DEATHS 0 TERMINAL 45 |
| |
| UNCENSORED DEATHS |
| 459 513 685 695 715 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 312 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 6 CENSORED DEATHS 0 TERMINAL 44 |
| |
| UNCENSORED DEATHS |
| 335 586 613 676 715 716 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 625 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 8 CENSORED DEATHS 0 TERMINAL 42 |
| |
| UNCENSORED DEATHS |
| 348 441 522 535 569 623 632 686 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
4-METHYLIMIDAZOLE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 1250 PPM |
| --------------------- |
| |
| TOTAL 49 UNCENSORED DEATHS 3 CENSORED DEATHS 0 TERMINAL 46 |
| |
| UNCENSORED DEATHS |
| 537 628 645 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
4-METHYLIMIDAZOLE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 100.0 100.0 100.0 100.0 98.0 96.0 96.0 96.0 90.0 |
| | |
| | |
|312 PPM | 100.0 100.0 100.0 98.0 98.0 98.0 98.0 96.0 94.0 88.0 |
| | |
| | |
|625 PPM | 100.0 100.0 100.0 98.0 98.0 96.0 92.0 90.0 86.0 84.0 |
| | |
| | |
|1250 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 98.0 98.0 93.9 93.9 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 312 PPM 625 PPM 1250 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 90.0% 88.0% 84.0% 93.9% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.631N P=0.990 P=0.514 P=0.735N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 613.4 606.8 544.5 603.3 |
|NATURAL DEATHS (C) | (52.9) (58.5) (38.8) (33.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 717.4 714.3 699.5 721.3 |
|(STANDARD ERROR) | ( 6.9) ( 8.6) (11.3) ( 4.7) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
4-METHYLIMIDAZOLE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 7 CENSORED DEATHS 0 TERMINAL 43 |
| |
| UNCENSORED DEATHS |
| 114 539 539 555 593 706 707 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 312 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 10 CENSORED DEATHS 0 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 525 629 632 656 668 697 702 705 721 727 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 625 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 7 CENSORED DEATHS 0 TERMINAL 43 |
| |
| UNCENSORED DEATHS |
| 539 541 635 684 685 707 720 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
4-METHYLIMIDAZOLE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 1250 PPM |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 10 CENSORED DEATHS 0 TERMINAL 40 |
| |
| UNCENSORED DEATHS |
| 409 447 552 569 640 647 665 685 687 711 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
4-METHYLIMIDAZOLE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 98.0 98.0 98.0 98.0 98.0 94.0 90.0 90.0 86.0 |
| | |
| | |
|312 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 98.0 98.0 92.0 80.0 |
| | |
| | |
|625 PPM | 100.0 100.0 100.0 100.0 100.0 100.0 96.0 96.0 94.0 86.0 |
| | |
| | |
|1250 PPM | 100.0 100.0 100.0 100.0 98.0 96.0 96.0 92.0 86.0 80.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM 312 PPM 625 PPM 1250 PPM |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 86.0% 80.0% 86.0% 80.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.635 P=0.635 P=1.000N P=0.601 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 536.1 666.2 644.4 601.2 |
|NATURAL DEATHS (C) | (75.6) (19.2) (28.8) (33.0) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 702.0 716.4 717.2 703.4 |
|(STANDARD ERROR) | (13.8) ( 5.1) ( 5.6) ( 9.7) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
4-METHYLIMIDAZOLE
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
312 PPM = 2
625 PPM = 3
1250 PPM = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 3 1 4
|
|
|
98 + 2 3 3 1 1 4 2 4
|
|
|
P 96 + 3 1 3 2 2 4 4 1
E |
R |
C |
E 94 + 3 3 2 4 21 1 4
N |
T |
|
S 92 + 3 3 2 1 1
U |
R |
V |
I 90 + 3 3 1 1
V |
A |
L |
88 + 3 3 2 2
|
|
|
86 + 3 3
|
|
|
84 + 3 3
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 4 obs hidden.
4-METHYLIMIDAZOLE
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
312 PPM = 2
625 PPM = 3
1250 PPM = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 1 1 4 2 3
|
|
|
98 + 1 4 4 2 13 2
|
|
|
96 + 4 34 22
|
|
|
P 94 + 1 41 4 2 2 3
E |
R |
C |
E 92 + 1 4 1 4 2 2
N |
T |
|
S 90 + 1 44 2 3 21
U |
R |
V |
I 88 + 4 4 22 3
V |
A |
L |
86 + 4 4 1 3 1
|
|
|
84 + 44 2 2
|
|
|
82 + 4 422
|
|
|
80 + 4 2 2
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 10 obs hidden.