TDMS Study 93020-08 Pathology Tables
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
FINAL #1 MICE
Facility: Southern Research Institute
Chemical CAS #: 693-13-0
Lock Date: 03/14/03
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 4| 3| 3| 3| 3| 3| 0| 3| 8| 3| 2| 3| 3| 5| 3| 3| 3| 9| 0| 3| 3| 1|
| 6| 3| 6| 4| 6| 7| 6| 3| 3| 3| 6| 1| 6| 1| 6| 6| 3| 3| 3| 3| 7| 3| 6| 3| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + I + + + + M + + A + + + + + + + + A + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + A + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + A + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + A + + + + + + + + A + + + +|
Cyst | 1 |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + + + A + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + A + + + + + + + + A + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + A + + + + + + + + A + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 |
Congestion | 2 |
Eosinophilic Focus | X X X X |
Infiltration Cellular, Mixed Cell | 1 1 1 2 1 2 1 2 |
Hepatocyte, Basophilic Focus | |
Hepatocyte, Clear Cell Focus | X X |
Hepatocyte, Karyomegaly | |
Hepatocyte, Mixed Cell Focus | X X |
Hepatocyte, Necrosis, Focal | 1 2 |
Hepatocyte, Vacuolization Cytoplasmic| 1 2 2 |
|__________________________________________________________________________|
Mesentery | + + + + + + + + + +|
Infiltration Cellular, Lymphoid | |
Infiltration Cellular, Mixed Cell | |
Inflammation | 4 |
Fat, Necrosis, Focal | 3 3 1 3 3 2 3 2|
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 2
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 4| 3| 3| 3| 3| 3| 0| 3| 8| 3| 2| 3| 3| 5| 3| 3| 3| 9| 0| 3| 3| 1|
| 6| 3| 6| 4| 6| 7| 6| 3| 3| 3| 6| 1| 6| 1| 6| 6| 3| 3| 3| 3| 7| 3| 6| 3| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Inflammation, Focal | |
Acinus, Atrophy, Focal | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Focal | |
Ulcer | |
Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mixed Cell | |
Thrombosis | 3 3 |
Artery, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Cytoplasmic Alteration, Focal | |
Degeneration, Cystic | |
Infiltration Cellular, | |
Polymorphonuclear | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 3
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 4| 3| 3| 3| 3| 3| 0| 3| 8| 3| 2| 3| 3| 5| 3| 3| 3| 9| 0| 3| 3| 1|
| 6| 3| 6| 4| 6| 7| 6| 3| 3| 3| 6| 1| 6| 1| 6| 6| 3| 3| 3| 3| 7| 3| 6| 3| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Angiectasis | 2 2 2 |
Pars Distalis, Cytoplasmic | |
Alteration, Focal | 2 |
Pars Distalis, Degeneration, Cystic, | |
Focal | |
Pars Distalis, Hyperplasia, Focal | 2|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Degeneration, Cystic, Focal| 2 3 2 2|
Follicular Cell, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | + |
Mediastinum, Infiltration Cellular, | |
Lymphoid | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + M + + + + + + + + + + + +|
Angiectasis | |
Cyst | 3 3 3 3 3 2 3 2 2 |
Hemorrhage | |
Inflammation, Suppurative | 4 |
Thrombosis | 3 |
Bilateral, Inflammation, Suppurative | |
|__________________________________________________________________________|
Oviduct | + |
Inflammation, Suppurative | 3 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | |
Inflammation, Suppurative | 2 |
__________________________________________|__________________________________________________________________________|
Page 4
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 4| 3| 3| 3| 3| 3| 0| 3| 8| 3| 2| 3| 3| 5| 3| 3| 3| 9| 0| 3| 3| 1|
| 6| 3| 6| 4| 6| 7| 6| 3| 3| 3| 6| 1| 6| 1| 6| 6| 3| 3| 3| 3| 7| 3| 6| 3| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Endometrium, Hyperplasia, Cystic | 3 3 3 3 3 2 3 2 3 2 3 2 1 3 2 3 2 3 2 3 3 3 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 4 2 3 3 3|
|__________________________________________________________________________|
Lymph Node | + + + + + +|
Iliac, Hemorrhage | |
Iliac, Hyperplasia, Lymphoid | 2|
Inguinal, Hyperplasia, Lymphoid | 3 |
Mediastinal, Ectasia | 3 |
Mediastinal, Hyperplasia, Lymphoid | |
Pancreatic, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Lymphoid | 3 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia, Lymphoid | 3 3 3 3|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 |
Hyperplasia, Lymphoid | 3 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hematopoietic Cell Proliferation | 2 3 2 3 2 4 3 3 3 3 3|
Hyperplasia, Histiocytic | |
Hyperplasia, Lymphoid | 3 2 2 |
Capsule, Inflammation, Chronic, Focal| |
|__________________________________________________________________________|
Thymus | + + + + + + + I + + + + I + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
__________________________________________|__________________________________________________________________________|
Page 5
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 4| 3| 3| 3| 3| 3| 0| 3| 8| 3| 2| 3| 3| 5| 3| 3| 3| 9| 0| 3| 3| 1|
| 6| 3| 6| 4| 6| 7| 6| 3| 3| 3| 6| 1| 6| 1| 6| 6| 3| 3| 3| 3| 7| 3| 6| 3| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3|
Control Dermis, Inflammation, Focal | 2|
Control Epidermis, Hyperplasia, Focal| |
Epidermis, Hyperplasia, Focal | 3|
Site of Application - Dermis, | |
Inflammation, Focal | 2 |
Site of Application - Epidermis, | |
Hyperplasia | 2 2 3|
Site of Application, Ulcer | 3 3|
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression, Focal | 3 |
Hemorrhage, Focal | 1 |
Infarct | X |
Cerebellum, Hippocampus, Necrosis | 2 |
|__________________________________________________________________________|
Peripheral Nerve | |
|__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Mineralization, Focal | |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 6
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 0| 7| 7| 7| 7| 7| 6| 7| 6| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 4| 3| 3| 3| 3| 3| 0| 3| 8| 3| 2| 3| 3| 5| 3| 3| 3| 9| 0| 3| 3| 1|
| 6| 3| 6| 4| 6| 7| 6| 3| 3| 3| 6| 1| 6| 1| 6| 6| 3| 3| 3| 3| 7| 3| 6| 3| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + A + + + + + + + + A + + + +|
Atrophy | 4 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Cyst | 1 |
Hyperplasia, Lymphoid | |
Infarct | 2 1 |
Inflammation | |
Metaplasia, Focal, Osseous | 1 1|
Nephropathy | 1 1 1 1 1 1 2 |
Capsule, Congestion | |
Papilla, Necrosis | |
Renal Tubule, Accumulation, Hyaline | |
Droplet | 3 |
Renal Tubule, Necrosis | 4 |
Renal Tubule, Vacuolization | |
Cytoplasmic, Focal | 2 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
__________________________________________|__________________________________________________________________________
Page 7
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| 6| 3| 7| 7| 7| 7| |
DAY ON TEST | 3| 0| 3| 3| 3| 9| 8| 3| 3| 3| 3| 3| 5| 1| 3| 3| 3| 3| 0| 8| 6| 2| 3| 3| 3| |
| 3| 6| 7| 7| 3| 8| 8| 6| 2| 7| 3| 3| 4| 9| 2| 6| 6| 7| 5| 3| 5| 0| 3| 7| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + A + + + + + + + I + + A + + + + + + + + M + + +| 42 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + + + + + + + A + + + + + + + + + + + +| 46 |
Cyst | | 1 1.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + + + + + + + + A + + + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + + + + + + + A + + + + + + + + + + + +| 46 |
Peyer's Patch, Hyperplasia, Lymphoid | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | | 1 2.0|
Congestion | | 1 2.0|
Eosinophilic Focus | X X | 6 |
Infiltration Cellular, Mixed Cell | 2 1 2 1 2 3 1 2 | 16 1.6|
Hepatocyte, Basophilic Focus | X | 1 |
Hepatocyte, Clear Cell Focus | X | 3 |
Hepatocyte, Karyomegaly | 1 | 1 1.0|
Hepatocyte, Mixed Cell Focus | | 2 |
Hepatocyte, Necrosis, Focal | 1 | 3 1.3|
Hepatocyte, Vacuolization Cytoplasmic| 1 3 | 5 1.8|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + + +| 23 |
Infiltration Cellular, Lymphoid | 3 | 1 3.0|
Infiltration Cellular, Mixed Cell | 3 | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| 6| 3| 7| 7| 7| 7| |
DAY ON TEST | 3| 0| 3| 3| 3| 9| 8| 3| 3| 3| 3| 3| 5| 1| 3| 3| 3| 3| 0| 8| 6| 2| 3| 3| 3| |
| 3| 6| 7| 7| 3| 8| 8| 6| 2| 7| 3| 3| 4| 9| 2| 6| 6| 7| 5| 3| 5| 0| 3| 7| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Inflammation | 3 3 | 3 3.3|
Fat, Necrosis, Focal | 3 2 3 3 3 3 2 2 3| 17 2.6|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Focal | 2 | 1 2.0|
Acinus, Atrophy, Focal | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 2 2 | 2 2.0|
Inflammation, Focal | 2 | 1 2.0|
Ulcer | 2 | 1 2.0|
Epithelium, Hyperplasia | 2 2 1 2 | 4 1.8|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + A + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mixed Cell | 2 | 1 2.0|
Thrombosis | 3 3 | 4 3.0|
Artery, Inflammation, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 1 1 | 2 1.0|
Cytoplasmic Alteration, Focal | 1 | 1 1.0|
Degeneration, Cystic | 2 | 1 2.0|
Infiltration Cellular, | | |
Polymorphonuclear | 3 | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| 6| 3| 7| 7| 7| 7| |
DAY ON TEST | 3| 0| 3| 3| 3| 9| 8| 3| 3| 3| 3| 3| 5| 1| 3| 3| 3| 3| 0| 8| 6| 2| 3| 3| 3| |
| 3| 6| 7| 7| 3| 8| 8| 6| 2| 7| 3| 3| 4| 9| 2| 6| 6| 7| 5| 3| 5| 0| 3| 7| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + M I + + + + + + + + M + + + + + + + + + + + + +| 46 |
Cyst | | 2 2.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + I + + + + + + + + +| 48 |
Angiectasis | | 3 2.0|
Pars Distalis, Cytoplasmic | | |
Alteration, Focal | 1 | 2 1.5|
Pars Distalis, Degeneration, Cystic, | | |
Focal | 2 | 1 2.0|
Pars Distalis, Hyperplasia, Focal | 3 2 | 3 2.3|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicle, Degeneration, Cystic, Focal| 1 2 2 2 1 3 2 1 1 1 | 14 1.8|
Follicular Cell, Hyperplasia, Focal | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | + M + + + | 5 |
Mediastinum, Infiltration Cellular, | | |
Lymphoid | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + I + + + + + + + + + + + M + + + M + + +| 46 |
Inflammation, Chronic | | 1 3.0|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 4 3| 2 3.5|
Cyst | 3 2 3 3 2 | 14 2.6|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| 6| 3| 7| 7| 7| 7| |
DAY ON TEST | 3| 0| 3| 3| 3| 9| 8| 3| 3| 3| 3| 3| 5| 1| 3| 3| 3| 3| 0| 8| 6| 2| 3| 3| 3| |
| 3| 6| 7| 7| 3| 8| 8| 6| 2| 7| 3| 3| 4| 9| 2| 6| 6| 7| 5| 3| 5| 0| 3| 7| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Hemorrhage | 3 2 | 2 2.5|
Inflammation, Suppurative | 3 | 2 3.5|
Thrombosis | 3 | 2 3.0|
Bilateral, Inflammation, Suppurative | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Oviduct | + + | 3 |
Inflammation, Suppurative | 3 3 | 3 3.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 1 3.0|
Hyperplasia, Lymphoid | 3 | 1 3.0|
Inflammation, Suppurative | 3 3 3 2 | 5 2.6|
Endometrium, Hyperplasia, Cystic | 3 3 3 3 3 2 3 3 3 1 3 3 3 3 3 2 3 1 2 3 3 3 3| 46 2.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + A + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 4 3 3 4 3 3 | 14 3.1|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + | 11 |
Iliac, Hemorrhage | 3 3 | 2 3.0|
Iliac, Hyperplasia, Lymphoid | 3 | 2 2.5|
Inguinal, Hyperplasia, Lymphoid | | 1 3.0|
Mediastinal, Ectasia | | 1 3.0|
Mediastinal, Hyperplasia, Lymphoid | 2 | 1 2.0|
Pancreatic, Hyperplasia, Lymphoid | 3 | 1 3.0|
Renal, Hyperplasia, Lymphoid | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + + + I + + + + + + + + + + + + + + + + +| 47 |
Hemorrhage | 3 | 1 3.0|
Hyperplasia, Lymphoid | 3 3 | 6 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + M + I + M + + +| 47 |
Ectasia | | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| 6| 3| 7| 7| 7| 7| |
DAY ON TEST | 3| 0| 3| 3| 3| 9| 8| 3| 3| 3| 3| 3| 5| 1| 3| 3| 3| 3| 0| 8| 6| 2| 3| 3| 3| |
| 3| 6| 7| 7| 3| 8| 8| 6| 2| 7| 3| 3| 4| 9| 2| 6| 6| 7| 5| 3| 5| 0| 3| 7| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Hyperplasia, Lymphoid | 3 3 | 3 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + A + + + + + + + + + + + +| 49 |
Congestion | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 2 3 3 3 3 3 3 2 4 2 2 3 2| 24 2.8|
Hyperplasia, Histiocytic | 3 | 1 3.0|
Hyperplasia, Lymphoid | 3 3 3 | 6 2.7|
Capsule, Inflammation, Chronic, Focal| 2 | 1 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + + M + + + + + + + + + + + + + + + + M + + +| 46 |
Hyperplasia, Lymphoid | 3 3 3 2| 5 2.8|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | | 1 3.0|
Control Dermis, Inflammation, Focal | | 1 2.0|
Control Epidermis, Hyperplasia, Focal| 3 | 1 3.0|
Epidermis, Hyperplasia, Focal | | 1 3.0|
Site of Application - Dermis, | | |
Inflammation, Focal | 1 1 | 3 1.3|
Site of Application - Epidermis, | | |
Hyperplasia | 1 2 | 5 2.0|
Site of Application, Ulcer | | 2 3.0|
Subcutaneous Tissue, Edema | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | 2 2 3 | 3 2.3|
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| 6| 3| 7| 7| 7| 7| |
DAY ON TEST | 3| 0| 3| 3| 3| 9| 8| 3| 3| 3| 3| 3| 5| 1| 3| 3| 3| 3| 0| 8| 6| 2| 3| 3| 3| |
| 3| 6| 7| 7| 3| 8| 8| 6| 2| 7| 3| 3| 4| 9| 2| 6| 6| 7| 5| 3| 5| 0| 3| 7| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression, Focal | 3 | 2 3.0|
Hemorrhage, Focal | | 1 1.0|
Infarct | | 1 |
Cerebellum, Hippocampus, Necrosis | | 1 2.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
|__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 | 2 3.0|
Mineralization, Focal | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nasolacrimal Duct, Inflammation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + A + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Atrophy | | 1 4.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Hyperplasia, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3| 6| 3| 7| 7| 7| 7| |
DAY ON TEST | 3| 0| 3| 3| 3| 9| 8| 3| 3| 3| 3| 3| 5| 1| 3| 3| 3| 3| 0| 8| 6| 2| 3| 3| 3| |
| 3| 6| 7| 7| 3| 8| 8| 6| 2| 7| 3| 3| 4| 9| 2| 6| 6| 7| 5| 3| 5| 0| 3| 7| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Kidney | + + + + + + + + + + + + A + + + + + + + + + + + +| 49 |
Congestion | | 1 3.0|
Cyst | | 1 1.0|
Hyperplasia, Lymphoid | 2 3 | 2 2.5|
Infarct | 1| 3 1.3|
Inflammation | 3 | 1 3.0|
Metaplasia, Focal, Osseous | 2 2 2| 5 1.6|
Nephropathy | 1 1 1 1 1 1 | 13 1.1|
Capsule, Congestion | 2| 1 2.0|
Papilla, Necrosis | 3 | 1 3.0|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | 3 3 | 3 3.0|
Renal Tubule, Necrosis | | 1 4.0|
Renal Tubule, Vacuolization | | |
Cytoplasmic, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
_____________________________________________________________________________________________________________________
| 7| 7| 5| 6| 7| 7| 6| 7| 6| 0| 6| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 6| 8| 3| 3| 5| 3| 9| 1| 8| 3| 3| 2| 0| 8| 3| 9| 3| 3| 3| 3| 3| 3| 3|
| 3| 7| 8| 3| 7| 7| 3| 3| 5| 2| 4| 7| 7| 5| 7| 8| 6| 0| 6| 6| 6| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + A + + + + + + + + + + + A + + + + + + + + +|
Cyst | |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + M + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + + + + + + + + + + + A + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + A + + +|
Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + A + + + + + A + + +|
Inflammation, Focal | |
Peyer's Patch, Hyperplasia, Lymphoid | 3 |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + + + + + A + + + + + A + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 |
Eosinophilic Focus | X |
Hematopoietic Cell Proliferation | 3 3 |
Hyperplasia, Focal, Lymphoid | |
Infiltration Cellular, | |
Polymorphonuclear | 3 |
Infiltration Cellular, Mixed Cell | 3 1 1 2 |
Mineralization, Focal | |
Hepatocyte, Clear Cell Focus | |
Hepatocyte, Necrosis, Focal | 3 2 |
Hepatocyte, Vacuolization Cytoplasmic| 3 |
|__________________________________________________________________________|
Mesentery | + + + + + + + + + + + +|
Inflammation | 4 3 3 |
Fat, Necrosis, Focal | 2 3 2 3 3 3 3 2 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 15
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
_____________________________________________________________________________________________________________________
| 7| 7| 5| 6| 7| 7| 6| 7| 6| 0| 6| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 6| 8| 3| 3| 5| 3| 9| 1| 8| 3| 3| 2| 0| 8| 3| 9| 3| 3| 3| 3| 3| 3| 3|
| 3| 7| 8| 3| 7| 7| 3| 3| 5| 2| 4| 7| 7| 5| 7| 8| 6| 0| 6| 6| 6| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Oral Mucosa | |
|__________________________________________________________________________|
Pancreas | + + + A + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Diffuse | 4 4 |
Acinus, Atrophy, Focal | |
Duct, Cyst, Focal, Multiple | 3 4 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 |
Epithelium, Hyperplasia | 2 2 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + A + + + + + + + + + + + + + + + + + + + + +|
Glands, Hyperplasia, Focal | 2 |
|__________________________________________________________________________|
Tooth | |
Malformation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 |
Infiltration Cellular, | |
Polymorphonuclear | 2 |
Inflammation, Chronic, Focal | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 |
Angiectasis | 2 |
Cytoplasmic Alteration, Focal | 1 2 |
Inflammation, Suppurative | 3 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Inflammation, Suppurative | 2 |
__________________________________________|__________________________________________________________________________|
Page 16
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
_____________________________________________________________________________________________________________________
| 7| 7| 5| 6| 7| 7| 6| 7| 6| 0| 6| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 6| 8| 3| 3| 5| 3| 9| 1| 8| 3| 3| 2| 0| 8| 3| 9| 3| 3| 3| 3| 3| 3| 3|
| 3| 7| 8| 3| 7| 7| 3| 3| 5| 2| 4| 7| 7| 5| 7| 8| 6| 0| 6| 6| 6| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + A + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
|__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + + + + + + + + + + I + + + + + + +|
Cyst | |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Pars Distalis, Hyperplasia, Focal | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
C-Cell, Hyperplasia | 2 |
Follicle, Degeneration, Cystic, Focal| 1 2 2 2 2 2 1 2|
Follicular Cell, Hyperplasia, Focal | 1 2 2 2 2 2 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | + + + |
Mediastinum, Inflammation, | |
Suppurative | 3 |
Nasal, Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 3 |
Cyst | 3 3 2 3 2 3|
Hyperplasia, Lymphoid | 3 |
Inflammation, Suppurative | 4 2 |
Thrombosis | 4 |
Interstitial Cell, Hyperplasia | 3 |
|__________________________________________________________________________|
Oviduct | + |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 17
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
_____________________________________________________________________________________________________________________
| 7| 7| 5| 6| 7| 7| 6| 7| 6| 0| 6| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 6| 8| 3| 3| 5| 3| 9| 1| 8| 3| 3| 2| 0| 8| 3| 9| 3| 3| 3| 3| 3| 3| 3|
| 3| 7| 8| 3| 7| 7| 3| 3| 5| 2| 4| 7| 7| 5| 7| 8| 6| 0| 6| 6| 6| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 3 3 3 4 4 |
Cervix, Hypertrophy | 3 |
Endometrium, Hyperplasia, Cystic | 3 3 3 3 3 3 3 2 3 3 3 3 3 3 3 2 3 3 3 3 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 4 4 3 |
|__________________________________________________________________________|
Lymph Node | + + + + + + |
Iliac, Ectasia | 3 |
Iliac, Hyperplasia, Lymphoid | 3 4 |
Mediastinal, Hemorrhage | |
Mediastinal, Hyperplasia, Lymphoid | 3 |
Mediastinal, Hyperplasia | 3 |
Pancreatic, Hemorrhage | |
Pancreatic, Hyperplasia, Lymphoid | |
Renal, Ectasia | 3 |
Renal, Hyperplasia, Lymphoid | 4 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + I + + +|
Ectasia | 3 |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Lymphoid | 3 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 2 3 3 2 3 3 2 4 4 3 3|
Hyperplasia, Lymphoid | 3 2 2 2 3 2 3 3 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 3 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 18
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
_____________________________________________________________________________________________________________________
| 7| 7| 5| 6| 7| 7| 6| 7| 6| 0| 6| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 6| 8| 3| 3| 5| 3| 9| 1| 8| 3| 3| 2| 0| 8| 3| 9| 3| 3| 3| 3| 3| 3| 3|
| 3| 7| 8| 3| 7| 7| 3| 3| 5| 2| 4| 7| 7| 5| 7| 8| 6| 0| 6| 6| 6| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Site of Application - Dermis, | |
Inflammation, Focal | 2 3|
Site of Application - Epidermis, | |
Hyperplasia | 1 3|
Site of Application, Ulcer | 2|
Subcutaneous Tissue, Angiectasis, | |
Focal | 2 |
Subcutaneous Tissue, Edema | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 |
|__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression, Focal | 4 |
Hemorrhage, Focal | 2 |
Inflammation, Focal | |
Cerebrum, Atrophy, Focal | |
Hippocampus, Necrosis, Acute | |
|__________________________________________________________________________|
Peripheral Nerve | + + |
|__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Hyperplasia, Histiocytic | 3 |
Infiltration Cellular, | |
__________________________________________|__________________________________________________________________________|
Page 19
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
_____________________________________________________________________________________________________________________
| 7| 7| 5| 6| 7| 7| 6| 7| 6| 0| 6| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 6| 8| 3| 3| 5| 3| 9| 1| 8| 3| 3| 2| 0| 8| 3| 9| 3| 3| 3| 3| 3| 3| 3|
| 3| 7| 8| 3| 7| 7| 3| 3| 5| 2| 4| 7| 7| 5| 7| 8| 6| 0| 6| 6| 6| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Polymorphonuclear | 3 3 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 |
Mediastinum, Hyperplasia, Lymphoid | 3 3 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + I + + +|
Cornea, Hyperplasia, Squamous | 2 |
Cornea, Inflammation, Chronic | 2 |
Iris, Synechia | |
Lens, Cataract | 3 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 3 2 |
Epithelium, Hyperplasia, Focal | |
|__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 3 |
Infarct | |
Infiltration Cellular, | |
Polymorphonuclear | 2 |
Infiltration Cellular, Mixed Cell | 2 |
Inflammation | |
Metaplasia, Focal, Osseous | 1 |
Nephropathy | 1 1 1 1 |
Renal Tubule, Accumulation, Hyaline | |
Droplet | |
Renal Tubule, Vacuolization | |
Cytoplasmic, Focal | 1 |
__________________________________________|__________________________________________________________________________|
Page 20
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
_____________________________________________________________________________________________________________________
| 7| 7| 5| 6| 7| 7| 6| 7| 6| 0| 6| 7| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 6| 8| 3| 3| 5| 3| 9| 1| 8| 3| 3| 2| 0| 8| 3| 9| 3| 3| 3| 3| 3| 3| 3|
| 3| 7| 8| 3| 7| 7| 3| 3| 5| 2| 4| 7| 7| 5| 7| 8| 6| 0| 6| 6| 6| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
10 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
|__________________________________________________________________________|
Ureter | + |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 21
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 5| 1| 3| 3| 3| 7| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 5| 1| 5| 3| 3| |
| 6| 6| 3| 7| 5| 9| 6| 2| 7| 9| 6| 7| 7| 6| 3| 0| 3| 6| 3| 7| 3| 7| 3| 7| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
10 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + A + + + +| 47 |
Cyst | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + A M + + +| 45 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A + + + + + + + + + + + + + + A + + + +| 46 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + + A + + + +| 45 |
Inflammation, Focal | 2 | 1 2.0|
Peyer's Patch, Hyperplasia, Lymphoid | | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A + + + + + + + + + + + + + + A + M + +| 44 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | 3 | 2 2.5|
Eosinophilic Focus | | 1 |
Hematopoietic Cell Proliferation | | 2 3.0|
Hyperplasia, Focal, Lymphoid | 2 | 1 2.0|
Infiltration Cellular, | | |
Polymorphonuclear | | 1 3.0|
Infiltration Cellular, Mixed Cell | 1 2 2 2 1 | 9 1.7|
Mineralization, Focal | 3 | 1 3.0|
Hepatocyte, Clear Cell Focus | X X | 2 |
Hepatocyte, Necrosis, Focal | 4 | 3 3.0|
Hepatocyte, Vacuolization Cytoplasmic| 2 2 | 3 2.3|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 5| 1| 3| 3| 3| 7| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 5| 1| 5| 3| 3| |
| 6| 6| 3| 7| 5| 9| 6| 2| 7| 9| 6| 7| 7| 6| 3| 0| 3| 6| 3| 7| 3| 7| 3| 7| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
10 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Mesentery | + + + + + + + +| 20 |
Inflammation | 3 3| 5 3.2|
Fat, Necrosis, Focal | 3 3 3 3 2| 13 2.7|
|__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
Acinus, Atrophy, Diffuse | | 2 4.0|
Acinus, Atrophy, Focal | 4 3 | 2 3.5|
Duct, Cyst, Focal, Multiple | | 2 3.5|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Ulcer | | 1 2.0|
Epithelium, Hyperplasia | 1 | 4 1.8|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
Glands, Hyperplasia, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Tooth | + | 1 |
Malformation | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 3 | 3 1.7|
Infiltration Cellular, | | |
Polymorphonuclear | | 1 2.0|
Inflammation, Chronic, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 5| 1| 3| 3| 3| 7| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 5| 1| 5| 3| 3| |
| 6| 6| 3| 7| 5| 9| 6| 2| 7| 9| 6| 7| 7| 6| 3| 0| 3| 6| 3| 7| 3| 7| 3| 7| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
10 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Accessory Adrenal Cortical Nodule | | 1 1.0|
Angiectasis | | 1 2.0|
Cytoplasmic Alteration, Focal | | 2 1.5|
Inflammation, Suppurative | | 1 3.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Inflammation, Suppurative | | 1 2.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + I + + + + + M M + M + + + + + + I + + +| 43 |
Cyst | 2 2 | 2 2.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Pars Distalis, Hyperplasia, Focal | 2 2 | 2 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 2 | 2 2.0|
C-Cell, Hyperplasia | 1 | 2 1.5|
Follicle, Degeneration, Cystic, Focal| 2 1 2 2 2 3 | 14 1.9|
Follicular Cell, Hyperplasia, Focal | 1 1 1 2 | 11 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | + + + + + | 8 |
Mediastinum, Inflammation, | | |
Suppurative | | 1 3.0|
Nasal, Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 5| 1| 3| 3| 3| 7| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 5| 1| 5| 3| 3| |
| 6| 6| 3| 7| 5| 9| 6| 2| 7| 9| 6| 7| 7| 6| 3| 0| 3| 6| 3| 7| 3| 7| 3| 7| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
10 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| 48 |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 3 2.7|
Cyst | 2 2 2 3 3 3 2 3 2 3| 16 2.6|
Hyperplasia, Lymphoid | | 1 3.0|
Inflammation, Suppurative | | 2 3.0|
Thrombosis | | 1 4.0|
Interstitial Cell, Hyperplasia | | 1 3.0|
|__________________________________________________________________________|____________|
Oviduct | | 1 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | 3 2 | 8 3.0|
Cervix, Hypertrophy | | 1 3.0|
Endometrium, Hyperplasia, Cystic | 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 3 2| 44 2.9|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 5 3.4|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + +| 13 |
Iliac, Ectasia | | 1 3.0|
Iliac, Hyperplasia, Lymphoid | | 2 3.5|
Mediastinal, Hemorrhage | 3 | 1 3.0|
Mediastinal, Hyperplasia, Lymphoid | 3| 2 3.0|
Mediastinal, Hyperplasia | | 1 3.0|
Pancreatic, Hemorrhage | 3 | 1 3.0|
Pancreatic, Hyperplasia, Lymphoid | 3 | 1 3.0|
Renal, Ectasia | | 1 3.0|
Renal, Hyperplasia, Lymphoid | | 1 4.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 5| 1| 3| 3| 3| 7| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 5| 1| 5| 3| 3| |
| 6| 6| 3| 7| 5| 9| 6| 2| 7| 9| 6| 7| 7| 6| 3| 0| 3| 6| 3| 7| 3| 7| 3| 7| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
10 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Hyperplasia, Lymphoid | 3 3 3 3| 4 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
Ectasia | | 1 3.0|
Hematopoietic Cell Proliferation | | 1 3.0|
Hyperplasia, Lymphoid | 3 3 4 3 3| 6 3.2|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Hematopoietic Cell Proliferation | 3 3 3 2 3 3 2 2 | 21 2.8|
Hyperplasia, Lymphoid | 3 3 2 3| 12 2.6|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + I + + + + + I + + + + + + + + +| 48 |
Hyperplasia, Lymphoid | 3| 4 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Site of Application - Dermis, | | |
Inflammation, Focal | | 2 2.5|
Site of Application - Epidermis, | | |
Hyperplasia | 1 | 3 1.7|
Site of Application, Ulcer | | 1 2.0|
Subcutaneous Tissue, Angiectasis, | | |
Focal | | 1 2.0|
Subcutaneous Tissue, Edema | 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | | 1 2.0|
|__________________________________________________________________________|____________|
Skeletal Muscle | + + | 4 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 5| 1| 3| 3| 3| 7| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 5| 1| 5| 3| 3| |
| 6| 6| 3| 7| 5| 9| 6| 2| 7| 9| 6| 7| 7| 6| 3| 0| 3| 6| 3| 7| 3| 7| 3| 7| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
10 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression, Focal | 3 | 2 3.5|
Hemorrhage, Focal | 2 | 2 2.0|
Inflammation, Focal | 1 | 1 1.0|
Cerebrum, Atrophy, Focal | 4 | 1 4.0|
Hippocampus, Necrosis, Acute | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | + | 3 |
|__________________________________________________________________________|____________|
Spinal Cord | + | 3 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 3.0|
Hyperplasia, Histiocytic | | 1 3.0|
Infiltration Cellular, | | |
Polymorphonuclear | | 2 3.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 1 | 2 1.0|
Mediastinum, Hyperplasia, Lymphoid | | 2 3.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + A + + + +| 48 |
Cornea, Hyperplasia, Squamous | | 1 2.0|
Cornea, Inflammation, Chronic | | 1 2.0|
Iris, Synechia | X | 1 |
Lens, Cataract | | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 6| 6| 7| 7| |
DAY ON TEST | 3| 3| 3| 3| 5| 1| 3| 3| 3| 7| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 5| 1| 5| 3| 3| |
| 6| 6| 3| 7| 5| 9| 6| 2| 7| 9| 6| 7| 7| 6| 3| 0| 3| 6| 3| 7| 3| 7| 3| 7| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
10 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| 49 |
Inflammation | | 2 2.5|
Epithelium, Hyperplasia, Focal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + A + + + +| 49 |
Hyperplasia, Lymphoid | | 2 2.5|
Infarct | 2 2 | 2 2.0|
Infiltration Cellular, | | |
Polymorphonuclear | | 1 2.0|
Infiltration Cellular, Mixed Cell | | 1 2.0|
Inflammation | 3| 1 3.0|
Metaplasia, Focal, Osseous | 3 | 2 2.0|
Nephropathy | 1 1 1 1 | 8 1.0|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | 2 | 1 2.0|
Renal Tubule, Vacuolization | | |
Cytoplasmic, Focal | | 1 1.0|
|__________________________________________________________________________|____________|
Ureter | | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
_____________________________________________________________________________________________________________________
| 0| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 3| 3| 3| 8| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3|
| 7| 3| 6| 7| 7| 0| 7| 3| 6| 4| 7| 6| 7| 7| 3| 4| 3| 7| 3| 6| 7| 3| 7| 3| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
20 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + A A + + + I + + + + + A + + + + + M + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + A A + + + + + + + + + A + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A A + + + + + + + + + A + + + + + + + + +|
Perforation | 3 |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A A + + + + + + + + + A + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + A + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Eosinophilic Focus | X X X |
Hyperplasia, Focal, Lymphoid | 2 |
Infiltration Cellular, Mixed Cell | 1 1 1|
Necrosis, Focal | 2 |
Hepatocyte, Basophilic Focus | X |
Hepatocyte, Eosinophilic Focus | X X X |
Hepatocyte, Mixed Cell Focus | |
Hepatocyte, Necrosis, Focal | 1 |
Hepatocyte, Vacuolization Cytoplasmic| |
|__________________________________________________________________________|
Mesentery | + + + + + + + + + + + +|
Hemorrhage | 3 |
Fat, Necrosis, Focal | 1 1 2 3 3 3 2 3|
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | 1 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 29
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
_____________________________________________________________________________________________________________________
| 0| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 3| 3| 3| 8| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3|
| 7| 3| 6| 7| 7| 0| 7| 3| 6| 4| 7| 6| 7| 7| 3| 4| 3| 7| 3| 6| 7| 3| 7| 3| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
20 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | |
Erosion | 2 |
Inflammation, Focal | 2 |
Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + A + + + + + + + + + A + + + + + + + + +|
|__________________________________________________________________________|
Tooth | + |
Peridontal Tissue, Inflammation, | |
Chronic | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + I + + + + + + + + + +|
Cardiomyopathy | 1 |
Thrombosis | 3 4 |
Artery, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + M +|
Accessory Adrenal Cortical Nodule | 1 |
Cytoplasmic Alteration, Focal | |
Degeneration, Cystic | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + M +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | 3 |
Hemorrhage | 3 |
Pars Distalis, Cytoplasmic | |
__________________________________________|__________________________________________________________________________|
Page 30
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
_____________________________________________________________________________________________________________________
| 0| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 3| 3| 3| 8| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3|
| 7| 3| 6| 7| 7| 0| 7| 3| 6| 4| 7| 6| 7| 7| 3| 4| 3| 7| 3| 6| 7| 3| 7| 3| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
20 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Alteration, Focal | 1 2 |
Pars Distalis, Hyperplasia, Focal | 2 2 2 |
Pars Intermedia, Hyperplasia, Focal | 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 |
Inflammation, Chronic, Focal | |
Follicle, Degeneration, Cystic, Focal| 2 2 1 1 3 1 2|
Follicular Cell, Hyperplasia, Focal | 2 1 2 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + I + + + + + + + + + +|
Degeneration, Cystic | 3 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + I + + + + + + + + +|
Angiectasis | 4 |
Cyst | 2 2 3 2 3 3 3|
Thrombosis | 4 |
Bilateral, Cyst | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Inflammation, Suppurative | 2 3 3 |
Endometrium, Hyperplasia, Cystic | 3 3 2 3 2 3 3 3 1 2 3 3 3 2 2 3 4 3 3 2 2 3 3 3|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 3 3 3 3 |
|__________________________________________________________________________|
Lymph Node | + + + + + |
Hyperplasia, Lymphoid | 3 |
Bronchial, Hyperplasia, Lymphoid | |
__________________________________________|__________________________________________________________________________|
Page 31
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
_____________________________________________________________________________________________________________________
| 0| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 3| 3| 3| 8| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3|
| 7| 3| 6| 7| 7| 0| 7| 3| 6| 4| 7| 6| 7| 7| 3| 4| 3| 7| 3| 6| 7| 3| 7| 3| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
20 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Iliac, Ectasia | 3 |
Iliac, Hyperplasia, Lymphoid | 3 |
Mediastinal, Hyperplasia, Lymphoid | 3 |
Renal, Hyperplasia, Lymphoid | 3 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + M + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + A + + + + + + + + +|
Ectasia | 3 3 4 |
Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | |
Atrophy | 2 |
Hematopoietic Cell Proliferation | 3 2 3 3 2 3 |
Hyperplasia, Lymphoid | 3 3 3 2 2 2|
|__________________________________________________________________________|
Thymus | + + + + A + + + + M + + + + I I + + + + M I + + +|
Hyperplasia, Lymphoid | 3 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + I + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Control Dermis, Inflammation, Focal | 2|
Site of Application - Dermis, | |
Inflammation, Focal | 2 2 1 2 |
Site of Application - Epidermis, | |
Hyperplasia | 2 2 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
|__________________________________________________________________________|
Skeletal Muscle | + |
__________________________________________|__________________________________________________________________________|
Page 32
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
_____________________________________________________________________________________________________________________
| 0| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 3| 3| 3| 8| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3|
| 7| 3| 6| 7| 7| 0| 7| 3| 6| 4| 7| 6| 7| 7| 3| 4| 3| 7| 3| 6| 7| 3| 7| 3| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
20 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
|__________________________________________________________________________|
Nose | + + + + A + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Nasolacrimal Duct, Inflammation | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + A + + + + + + + + +|
Atrophy | |
Phthisis Bulbi | |
Cornea, Hyperplasia, Squamous | 1 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia, Focal | 1 |
|__________________________________________________________________________|
Lacrimal Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Hydronephrosis | 3 |
Hyperplasia, Lymphoid | 2 |
Infarct | 2|
Nephropathy | 1 1 1 1 1 |
Renal Tubule, Vacuolization | |
Cytoplasmic, Focal | 2 |
__________________________________________|__________________________________________________________________________|
Page 33
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
_____________________________________________________________________________________________________________________
| 0| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 6| 3| 3| 3| 8| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3|
| 7| 3| 6| 7| 7| 0| 7| 3| 6| 4| 7| 6| 7| 7| 3| 4| 3| 7| 3| 6| 7| 3| 7| 3| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
20 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 34
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 0| 7| 7| 7| 7| 6| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 3| 1| 7| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 9| 3| 5| 3| 3| |
| 3| 6| 3| 5| 3| 3| 2| 3| 4| 9| 3| 6| 7| 7| 3| 7| 3| 6| 6| 3| 0| 7| 3| 3| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
20 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 |
|__________________________________________________________________________|____________|
Gallbladder | + + + A + + + + A + + + A + + + + + + + + + + + +| 42 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + A + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + A + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + + + + A + + + A + + + + + + + + + + + +| 44 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + + + + A + + + A + + + + + + + + + + + +| 44 |
Perforation | | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + + + + A + + + A + + + + + + + + + + + +| 44 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + + + + A + + + A + + + + + + + + + + + +| 45 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Eosinophilic Focus | X X X | 6 |
Hyperplasia, Focal, Lymphoid | 2 | 2 2.0|
Infiltration Cellular, Mixed Cell | 2 1 1 1 1 1 2 | 10 1.2|
Necrosis, Focal | | 1 2.0|
Hepatocyte, Basophilic Focus | | 1 |
Hepatocyte, Eosinophilic Focus | X | 4 |
Hepatocyte, Mixed Cell Focus | X | 1 |
Hepatocyte, Necrosis, Focal | | 1 1.0|
Hepatocyte, Vacuolization Cytoplasmic| 1 | 1 1.0|
|__________________________________________________________________________|____________|
Mesentery | + + | 14 |
Hemorrhage | | 1 3.0|
Fat, Necrosis, Focal | 3 | 9 2.3|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 0| 7| 7| 7| 7| 6| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 3| 1| 7| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 9| 3| 5| 3| 3| |
| 3| 6| 3| 5| 3| 3| 2| 3| 4| 9| 3| 6| 7| 7| 3| 7| 3| 6| 6| 3| 0| 7| 3| 3| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
20 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Acinus, Atrophy, Focal | | 1 1.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Diverticulum | 1 | 1 1.0|
Erosion | 1 | 2 1.5|
Inflammation, Focal | | 1 2.0|
Epithelium, Hyperplasia | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + A + + + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Tooth | | 1 |
Peridontal Tissue, Inflammation, | | |
Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cardiomyopathy | | 1 1.0|
Thrombosis | | 2 3.5|
Artery, Inflammation, Chronic | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Accessory Adrenal Cortical Nodule | | 1 1.0|
Cytoplasmic Alteration, Focal | 2 | 1 2.0|
Degeneration, Cystic | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 0| 7| 7| 7| 7| 6| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 3| 1| 7| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 9| 3| 5| 3| 3| |
| 3| 6| 3| 5| 3| 3| 2| 3| 4| 9| 3| 6| 7| 7| 3| 7| 3| 6| 6| 3| 0| 7| 3| 3| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
20 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Cyst | | 1 3.0|
Hemorrhage | | 1 3.0|
Pars Distalis, Cytoplasmic | | |
Alteration, Focal | 2 1 | 4 1.5|
Pars Distalis, Hyperplasia, Focal | 2 2 2 2 | 7 2.0|
Pars Intermedia, Hyperplasia, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 3 2.7|
Inflammation, Chronic, Focal | 1 | 1 1.0|
Follicle, Degeneration, Cystic, Focal| 2 1 2 2 2 1 1 2 2 2 2| 18 1.7|
Follicular Cell, Hyperplasia, Focal | 1 1 1 1 | 9 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | + | 3 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| 48 |
Degeneration, Cystic | | 1 3.0|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | | 1 4.0|
Cyst | 4 4 3 2 3 3 | 13 2.8|
Thrombosis | | 1 4.0|
Bilateral, Cyst | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 0| 7| 7| 7| 7| 6| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 3| 1| 7| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 9| 3| 5| 3| 3| |
| 3| 6| 3| 5| 3| 3| 2| 3| 4| 9| 3| 6| 7| 7| 3| 7| 3| 6| 6| 3| 0| 7| 3| 3| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
20 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Hyperplasia, Lymphoid | 3 | 1 3.0|
Inflammation, Suppurative | 2 3 3 | 6 2.7|
Endometrium, Hyperplasia, Cystic | 2 2 3 3 3 3 3 3 3 4 3 3 2 3 3 3 3 3 3 3 3 3 3| 47 2.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 3 3 3| 10 2.9|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + | 10 |
Hyperplasia, Lymphoid | | 1 3.0|
Bronchial, Hyperplasia, Lymphoid | 3 | 1 3.0|
Iliac, Ectasia | | 1 3.0|
Iliac, Hyperplasia, Lymphoid | 3 | 2 3.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 3.0|
Renal, Hyperplasia, Lymphoid | 2 | 2 2.5|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | 3 | 2 2.5|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Ectasia | 4 2 | 5 3.2|
Hyperplasia, Lymphoid | 3 3 | 2 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Spleen | X | 1 |
Atrophy | | 1 2.0|
Hematopoietic Cell Proliferation | 3 3 2 2 3 2 4 3 2 3 2 2| 18 2.6|
Hyperplasia, Lymphoid | 4 2 2 2 3 2 | 12 2.5|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 44 |
Hyperplasia, Lymphoid | 3 3 | 4 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 0| 7| 7| 7| 7| 6| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 3| 1| 7| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 9| 3| 5| 3| 3| |
| 3| 6| 3| 5| 3| 3| 2| 3| 4| 9| 3| 6| 7| 7| 3| 7| 3| 6| 6| 3| 0| 7| 3| 3| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
20 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Control Dermis, Inflammation, Focal | | 1 2.0|
Site of Application - Dermis, | | |
Inflammation, Focal | 1 1 1 | 7 1.4|
Site of Application - Epidermis, | | |
Hyperplasia | 1 1 1 1 | 7 1.4|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3 | 1 3.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation | 2 | 1 2.0|
Nasolacrimal Duct, Inflammation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 0| 7| 7| 7| 7| 6| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| |
DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 3| 1| 7| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 9| 3| 5| 3| 3| |
| 3| 6| 3| 5| 3| 3| 2| 3| 4| 9| 3| 6| 7| 7| 3| 7| 3| 6| 6| 3| 0| 7| 3| 3| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
20 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 4 4| 2 4.0|
Phthisis Bulbi | X| 1 |
Cornea, Hyperplasia, Squamous | | 1 1.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Hyperplasia, Focal | | 1 1.0|
|__________________________________________________________________________|____________|
Lacrimal Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 2 1 | 4 1.8|
Hydronephrosis | | 1 3.0|
Hyperplasia, Lymphoid | | 1 2.0|
Infarct | | 1 2.0|
Nephropathy | 1 1 1 2 1 1 | 11 1.1|
Renal Tubule, Vacuolization | | |
Cytoplasmic, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 1| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 0| 8| 3| 3| 3| 6| 3| 2| 3| 3| 1| 5| 3| 3| 2| 3| 0| 3| 3| 3| 3| 3|
| 7| 6| 6| 5| 1| 6| 3| 6| 9| 6| 9| 6| 7| 7| 1| 7| 6| 9| 7| 4| 7| 2| 2| 2| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
40 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + + + A + + + + + + + + + + I + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + A + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + A + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + A + + + + +|
Edema | 3 |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + A + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + A + + + + + + + + + + A + + + + +|
Epithelium, Hyperplasia, Focal | |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + A + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | |
Hematopoietic Cell Proliferation | 2 |
Infiltration Cellular, | |
Polymorphonuclear | 3 |
Infiltration Cellular, Mixed Cell | 1 1 1 1 1 1 1 1 1|
Hepatocyte, Basophilic Focus | X |
Hepatocyte, Clear Cell Focus | |
Hepatocyte, Mixed Cell Focus | X X X X X |
Hepatocyte, Necrosis, Focal | 1 |
Hepatocyte, Vacuolization Cytoplasmic| 1 4 |
|__________________________________________________________________________|
Mesentery | + + + + + + + |
Inflammation | |
Artery, Inflammation | |
Fat, Necrosis, Focal | 1 3 3 3 1 3 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | 3 4 |
__________________________________________|__________________________________________________________________________|
Page 41
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 1| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 0| 8| 3| 3| 3| 6| 3| 2| 3| 3| 1| 5| 3| 3| 2| 3| 0| 3| 3| 3| 3| 3|
| 7| 6| 6| 5| 1| 6| 3| 6| 9| 6| 9| 6| 7| 7| 1| 7| 6| 9| 7| 4| 7| 2| 2| 2| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
40 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Duct, Cyst, Focal, Multiple | 4 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + M + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | 1 |
Inflammation, Focal | 3 |
Ulcer | 3 |
Epithelium, Hyperplasia | 3 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 |
|__________________________________________________________________________|
Tooth | + + |
Malformation | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 2 1 1 |
Degeneration, Cystic | |
Necrosis, Focal | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + M + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + I + + + + I I + + + +|
Angiectasis | 2 |
__________________________________________|__________________________________________________________________________|
Page 42
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 1| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 0| 8| 3| 3| 3| 6| 3| 2| 3| 3| 1| 5| 3| 3| 2| 3| 0| 3| 3| 3| 3| 3|
| 7| 6| 6| 5| 1| 6| 3| 6| 9| 6| 9| 6| 7| 7| 1| 7| 6| 9| 7| 4| 7| 2| 2| 2| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
40 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Pars Distalis, Cytoplasmic | |
Alteration, Focal | 1 |
Pars Distalis, Hyperplasia, Focal | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Follicle, Degeneration, Cystic, Focal| 2 1 2 2 |
Follicular Cell, Hyperplasia, Focal | 1 |
Follicular Cell, Vacuolization | |
Cytoplasmic, Focal | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Tissue NOS | + + + |
Mediastinum, Infiltration Cellular, | |
Lymphoid | |
Mediastinum, Inflammation, | |
Suppurative | 3 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + I I + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | 3 3 3 4 2 2 2 4|
Inflammation, Suppurative | 4 |
Bilateral, Inflammation, Suppurative | 3 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Suppurative | 2 1 |
Thrombosis | 3 |
Endometrium, Hyperplasia, Cystic | 3 3 3 2 3 3 1 2 3 2 2 3 3 3 4 3 3 3 3 4 3 3 1 3|
|__________________________________________________________________________|
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 43
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 1| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 0| 8| 3| 3| 3| 6| 3| 2| 3| 3| 1| 5| 3| 3| 2| 3| 0| 3| 3| 3| 3| 3|
| 7| 6| 6| 5| 1| 6| 3| 6| 9| 6| 9| 6| 7| 7| 1| 7| 6| 9| 7| 4| 7| 2| 2| 2| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
40 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 |
|__________________________________________________________________________|
Lymph Node | + + + + + + + +|
Iliac, Ectasia | 3 3 2 |
Iliac, Hyperplasia, Lymphoid | 3 2 |
Mediastinal, Hyperplasia, Lymphoid | 3 3 3 |
Pancreatic, Hyperplasia, Lymphoid | 3|
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + M + + +|
Hyperplasia, Lymphoid | 3 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hemorrhage | |
Hyperplasia, Lymphoid | 3 3 3 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 4 2 2 3 |
Hyperplasia, Lymphoid | 2 3 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Control Dermis, Hyperplasia, Focal | |
Control Dermis, Inflammation, Focal | |
Control Epidermis, Hyperplasia, Focal| |
Site of Application - Dermis, | |
Fibrosis | 1 |
Site of Application - Dermis, | |
Inflammation, Focal | |
Site of Application - Epidermis, | |
__________________________________________|__________________________________________________________________________|
Page 44
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 1| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 0| 8| 3| 3| 3| 6| 3| 2| 3| 3| 1| 5| 3| 3| 2| 3| 0| 3| 3| 3| 3| 3|
| 7| 6| 6| 5| 1| 6| 3| 6| 9| 6| 9| 6| 7| 7| 1| 7| 6| 9| 7| 4| 7| 2| 2| 2| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
40 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
Hyperplasia | 1 1 1 |
Subcutaneous Tissue, Edema | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 1|
|__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression, Focal | 3 |
|__________________________________________________________________________|
Peripheral Nerve | |
|__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Foreign Body | 1 |
Hyperplasia, Histiocytic | |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________|__________________________________________________________________________|
Page 45
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 1| 4| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 0| 8| 3| 3| 3| 6| 3| 2| 3| 3| 1| 5| 3| 3| 2| 3| 0| 3| 3| 3| 3| 3|
| 7| 6| 6| 5| 1| 6| 3| 6| 9| 6| 9| 6| 7| 7| 1| 7| 6| 9| 7| 4| 7| 2| 2| 2| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
40 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Hyperplasia, Lymphoid | 2 |
Infarct | |
Metaplasia, Focal, Osseous | 1 |
Nephropathy | 1 1 1 1 1 2 1 1 2 |
Renal Tubule, Accumulation, Hyaline | |
Droplet | 3 |
|__________________________________________________________________________|
Ureter | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 46
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 5| |
DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 2| 1| 2| 2| 3| 8| |
| 6| 3| 7| 8| 6| 3| 7| 6| 6| 6| 7| 7| 3| 3| 3| 6| 3| 9| 7| 9| 9| 8| 9| 7| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
40 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + + A + + + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + A + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + A + + + + + + + + + + + + + + + + + + + + +| 47 |
Edema | | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + + + + + + + + +| 46 |
Epithelium, Hyperplasia, Focal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + A + + + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Clear Cell Focus | X | 1 |
Hematopoietic Cell Proliferation | | 1 2.0|
Infiltration Cellular, | | |
Polymorphonuclear | | 1 3.0|
Infiltration Cellular, Mixed Cell | 1 1 1 1 2 1 1 1 2 2 1 1 2| 22 1.2|
Hepatocyte, Basophilic Focus | | 1 |
Hepatocyte, Clear Cell Focus | X| 1 |
Hepatocyte, Mixed Cell Focus | X| 6 |
Hepatocyte, Necrosis, Focal | | 1 1.0|
Hepatocyte, Vacuolization Cytoplasmic| 2 1 3| 5 2.2|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + +| 18 |
Inflammation | 2 | 1 2.0|
Artery, Inflammation | 2 | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 5| |
DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 2| 1| 2| 2| 3| 8| |
| 6| 3| 7| 8| 6| 3| 7| 6| 6| 6| 7| 7| 3| 3| 3| 6| 3| 9| 7| 9| 9| 8| 9| 7| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
40 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Fat, Necrosis, Focal | 3 2 1 3 2 3 3 3 1| 15 2.3|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Atrophy, Focal | 1 | 3 2.7|
Duct, Cyst, Focal, Multiple | | 1 4.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Diverticulum | | 1 1.0|
Inflammation, Focal | | 1 3.0|
Ulcer | 2 | 2 2.5|
Epithelium, Hyperplasia | | 1 3.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | | 1 1.0|
|__________________________________________________________________________|____________|
Tooth | | 2 |
Malformation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | | 3 1.3|
Degeneration, Cystic | 2 | 1 2.0|
Necrosis, Focal | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 5| |
DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 2| 1| 2| 2| 3| 8| |
| 6| 3| 7| 8| 6| 3| 7| 6| 6| 6| 7| 7| 3| 3| 3| 6| 3| 9| 7| 9| 9| 8| 9| 7| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
40 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| 46 |
Angiectasis | 2 1 | 3 1.7|
Pars Distalis, Cytoplasmic | | |
Alteration, Focal | | 1 1.0|
Pars Distalis, Hyperplasia, Focal | 2 2 2 | 3 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 2.0|
Follicle, Degeneration, Cystic, Focal| 2 2 2 2 2 3 1 2 | 12 1.9|
Follicular Cell, Hyperplasia, Focal | 2 2 1 | 4 1.5|
Follicular Cell, Vacuolization | | |
Cytoplasmic, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Tissue NOS | + | 4 |
Mediastinum, Infiltration Cellular, | | |
Lymphoid | 2 | 1 2.0|
Mediastinum, Inflammation, | | |
Suppurative | | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + I + + + + + +| 47 |
|__________________________________________________________________________|____________|
Ovary | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 3 | 1 3.0|
Cyst | 2 2 3 3 2 2 3 2 2 2| 18 2.6|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 5| |
DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 2| 1| 2| 2| 3| 8| |
| 6| 3| 7| 8| 6| 3| 7| 6| 6| 6| 7| 7| 3| 3| 3| 6| 3| 9| 7| 9| 9| 8| 9| 7| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
40 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Inflammation, Suppurative | 3 | 2 3.5|
Bilateral, Inflammation, Suppurative | | 1 3.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Suppurative | | 2 1.5|
Thrombosis | | 1 3.0|
Endometrium, Hyperplasia, Cystic | 2 2 3 2 3 3 3 3 3 2 3 3 3 4 3 2 3 3 3 3 3 3 3 3 3| 49 2.8|
|__________________________________________________________________________|____________|
Vagina | + | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 2 3.0|
|__________________________________________________________________________|____________|
Lymph Node | + + | 10 |
Iliac, Ectasia | | 3 2.7|
Iliac, Hyperplasia, Lymphoid | | 2 2.5|
Mediastinal, Hyperplasia, Lymphoid | | 3 3.0|
Pancreatic, Hyperplasia, Lymphoid | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + I + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia, Lymphoid | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 3 3 | 2 3.0|
Hemorrhage | 3 | 1 3.0|
Hyperplasia, Lymphoid | 3 3 | 5 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 2 3 2 4 3 3 | 13 2.8|
Hyperplasia, Lymphoid | 2 2 2 3 | 6 2.3|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + M + + + + + + M + I + + + + + +| 47 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 5| |
DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 2| 1| 2| 2| 3| 8| |
| 6| 3| 7| 8| 6| 3| 7| 6| 6| 6| 7| 7| 3| 3| 3| 6| 3| 9| 7| 9| 9| 8| 9| 7| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
40 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Hyperplasia, Lymphoid | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Control Dermis, Hyperplasia, Focal | 1 | 1 1.0|
Control Dermis, Inflammation, Focal | 1 | 1 1.0|
Control Epidermis, Hyperplasia, Focal| 1 | 1 1.0|
Site of Application - Dermis, | | |
Fibrosis | | 1 1.0|
Site of Application - Dermis, | | |
Inflammation, Focal | 1 2 | 2 1.5|
Site of Application - Epidermis, | | |
Hyperplasia | 1 2 2 1 | 7 1.3|
Subcutaneous Tissue, Edema | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | | 2 2.0|
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression, Focal | | 1 3.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
|__________________________________________________________________________|____________|
Spinal Cord | + + | 2 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 5| |
DAY ON TEST | 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 2| 1| 2| 2| 3| 8| |
| 6| 3| 7| 8| 6| 3| 7| 6| 6| 6| 7| 7| 3| 3| 3| 6| 3| 9| 7| 9| 9| 8| 9| 7| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
40 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 2.0|
Foreign Body | | 1 1.0|
Hyperplasia, Histiocytic | 3 | 1 3.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 2 1 | 2 1.5|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + A + + + + + + + + + + + + + + + + + + + + +| 49 |
Hydronephrosis | 3 | 1 3.0|
Hyperplasia, Lymphoid | | 1 2.0|
Infarct | 2 | 1 2.0|
Metaplasia, Focal, Osseous | | 1 1.0|
Nephropathy | 1 1 1 1 1 2 1 2 1 | 18 1.2|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | 3 | 2 3.0|
|__________________________________________________________________________|____________|
Ureter | + | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 2| 3| 2| 3| 2| 2| 3| 3| 2| 3| 3| 3| 2| 3| 2| 3| 3| 3| 0| 8| 3| 0|
| 1| 0| 0| 9| 1| 9| 0| 9| 9| 1| 1| 9| 1| 2| 1| 9| 2| 5| 1| 2| 1| 2| 2| 0| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + I + + +|
Cyst | 2 |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
Peyer's Patch, Hyperplasia, Lymphoid | 3 |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Basophilic Focus | |
Clear Cell Focus | X |
Eosinophilic Focus | X |
Fibrosis, Focal | 2 |
Infiltration Cellular, | |
Polymorphonuclear | 4 |
Infiltration Cellular, Mixed Cell | 3 1 1 1 1 1 2 |
Bile Duct, Hyperplasia | 2 |
Hepatocyte, Clear Cell Focus | X X X X X X X X X X X |
Hepatocyte, Eosinophilic Focus | X X |
Hepatocyte, Mixed Cell Focus | |
Hepatocyte, Necrosis, Focal | 3 2 2 1 1 |
Hepatocyte, Vacuolization Cytoplasmic| 2 2 1 2 1 1 2 1 1 |
|__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 53
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 2| 3| 2| 3| 2| 2| 3| 3| 2| 3| 3| 3| 2| 3| 2| 3| 3| 3| 0| 8| 3| 0|
| 1| 0| 0| 9| 1| 9| 0| 9| 9| 1| 1| 9| 1| 2| 1| 9| 2| 5| 1| 2| 1| 2| 2| 0| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Fat, Necrosis, Focal | 2 2|
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 |
|__________________________________________________________________________|
Tooth | + + + + + + + + + + + |
Malformation | 2 3 4 2 1 3 4 3 2 3 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 1 |
Cytoplasmic Alteration, Focal | 2 1 2 2 |
Vacuolization Cytoplasmic, Focal | 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + M +|
Angiectasis | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + M + + + + + + +|
Cyst | 1 |
Pars Distalis, Cytoplasmic | |
__________________________________________|__________________________________________________________________________|
Page 54
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 2| 3| 2| 3| 2| 2| 3| 3| 2| 3| 3| 3| 2| 3| 2| 3| 3| 3| 0| 8| 3| 0|
| 1| 0| 0| 9| 1| 9| 0| 9| 9| 1| 1| 9| 1| 2| 1| 9| 2| 5| 1| 2| 1| 2| 2| 0| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Alteration, Focal | 2 |
Pars Distalis, Hyperplasia, Focal | 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 |
Follicle, Degeneration, Cystic, Focal| 3 2 |
Follicular Cell, Hyperplasia, Focal | 2 2 2 3 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Peritoneum | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
Inflammation, Chronic | 3 4 3 3 3|
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia, Focal | |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 3 |
|__________________________________________________________________________|
Lymph Node | + + + + |
Inguinal, Hyperplasia, Lymphoid | 3 3 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + M + M +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 55
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 2| 3| 2| 3| 2| 2| 3| 3| 2| 3| 3| 3| 2| 3| 2| 3| 3| 3| 0| 8| 3| 0|
| 1| 0| 0| 9| 1| 9| 0| 9| 9| 1| 1| 9| 1| 2| 1| 9| 2| 5| 1| 2| 1| 2| 2| 0| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 3 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Hematopoietic Cell Proliferation | 2 3 3 3 3 |
Hyperplasia, Lymphoid | 3 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + I + + + I|
Cyst | 2 |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 |
Epidermis, Hyperplasia, Focal | |
Site of Application - Dermis, | |
Inflammation, Focal | 2 |
Site of Application - Epidermis, | |
Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 2|
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + |
|__________________________________________________________________________|
Spinal Cord | + |
__________________________________________|__________________________________________________________________________|
Page 56
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 2| 3| 2| 3| 2| 2| 3| 3| 2| 3| 3| 3| 2| 3| 2| 3| 3| 3| 0| 8| 3| 0|
| 1| 0| 0| 9| 1| 9| 0| 9| 9| 1| 1| 9| 1| 2| 1| 9| 2| 5| 1| 2| 1| 2| 2| 0| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2|
Hyperplasia, Histiocytic | 2 |
Hyperplasia, Lymphoid | 2 |
Inflammation, Chronic, Focal | 2 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 1 2 |
Mediastinum, Hyperplasia, Lymphoid | 2 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 3 |
Nasolacrimal Duct, Hyperplasia, Focal| 2 |
Nasolacrimal Duct, Inflammation | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + I|
Atrophy | 4 |
Inflammation | 2 |
Cornea, Inflammation, Chronic | 1 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Epithelium, Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 |
Hydronephrosis | |
Infarct | |
Metaplasia, Focal, Osseous | 2 |
Nephropathy | 1 2 1 2 2 1 1 1 1 1 1 1 1 1 2 2 3 1 1 2 1 1 1 2 2|
Renal Tubule, Hyperplasia, Focal | 1 1 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 57
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 2| 3| 2| 3| 2| 2| 3| 3| 2| 3| 3| 3| 2| 3| 2| 3| 3| 3| 0| 8| 3| 0|
| 1| 0| 0| 9| 1| 9| 0| 9| 9| 1| 1| 9| 1| 2| 1| 9| 2| 5| 1| 2| 1| 2| 2| 0| 6|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 58
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| |
DAY ON TEST | 3| 9| 3| 1| 3| 7| 3| 3| 3| 3| 4| 2| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 9| |
| 1| 2| 0| 5| 0| 2| 1| 1| 2| 2| 0| 1| 9| 0| 0| 0| 0| 0| 1| 1| 7| 2| 0| 0| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + A + + + + + + + + A + + + + + + + + + A + + + A| 45 |
Cyst | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + A + + + A| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + + + + + A + + + + + + + + + A + + + A| 46 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + + + + + + A + + + + + + + + + A + + + A| 46 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + + + + + A + + + + + + + + + A + + + A| 46 |
Necrosis | 4 | 1 4.0|
Peyer's Patch, Hyperplasia, Lymphoid | | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + + + + + A + + + + + + + + + A + + + A| 46 |
Peyer's Patch, Hyperplasia, Lymphoid | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 1 2.0|
Basophilic Focus | X | 1 |
Clear Cell Focus | X | 2 |
Eosinophilic Focus | X | 2 |
Fibrosis, Focal | | 1 2.0|
Infiltration Cellular, | | |
Polymorphonuclear | | 1 4.0|
Infiltration Cellular, Mixed Cell | 1 | 8 1.4|
Bile Duct, Hyperplasia | | 1 2.0|
Hepatocyte, Clear Cell Focus | X X X X X X X X | 19 |
Hepatocyte, Eosinophilic Focus | | 2 |
Hepatocyte, Mixed Cell Focus | X | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| |
DAY ON TEST | 3| 9| 3| 1| 3| 7| 3| 3| 3| 3| 4| 2| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 9| |
| 1| 2| 0| 5| 0| 2| 1| 1| 2| 2| 0| 1| 9| 0| 0| 0| 0| 0| 1| 1| 7| 2| 0| 0| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Hepatocyte, Necrosis, Focal | | 5 1.8|
Hepatocyte, Vacuolization Cytoplasmic| 2 2 3 2 3 3 2 1 3 | 18 1.9|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Fat, Necrosis, Focal | 3 2 | 4 2.3|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Hyperplasia | 2 2 | 2 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 1 2 2| 4 1.5|
|__________________________________________________________________________|____________|
Tooth | + + + + + + + | 18 |
Malformation | 2 3 3 2 2 2 2 | 18 2.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 1 | 3 1.0|
Cytoplasmic Alteration, Focal | 1 1 1 1 1 | 9 1.3|
Vacuolization Cytoplasmic, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| |
DAY ON TEST | 3| 9| 3| 1| 3| 7| 3| 3| 3| 3| 4| 2| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 9| |
| 1| 2| 0| 5| 0| 2| 1| 1| 2| 2| 0| 1| 9| 0| 0| 0| 0| 0| 1| 1| 7| 2| 0| 0| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Hyperplasia | | 2 2.5|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | | 1 1.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + M + + + + + + + + + +| 48 |
Cyst | | 1 1.0|
Pars Distalis, Cytoplasmic | | |
Alteration, Focal | | 1 2.0|
Pars Distalis, Hyperplasia, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
C-Cell, Hyperplasia | | 1 2.0|
Follicle, Degeneration, Cystic, Focal| 1 2 | 4 2.0|
Follicular Cell, Hyperplasia, Focal | 1 2 1 | 7 1.9|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 3 3 2 | 3 2.7|
Inflammation, Chronic | 3 3 3 3 3 3 | 11 3.1|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Hyperplasia, Focal | 2 2 | 2 2.0|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| |
DAY ON TEST | 3| 9| 3| 1| 3| 7| 3| 3| 3| 3| 4| 2| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 9| |
| 1| 2| 0| 5| 0| 2| 1| 1| 2| 2| 0| 1| 9| 0| 0| 0| 0| 0| 1| 1| 7| 2| 0| 0| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
Hyperplasia | 2 3 3 3 3 3 | 9 2.9|
|__________________________________________________________________________|____________|
Lymph Node | + + | 6 |
Inguinal, Hyperplasia, Lymphoid | | 2 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 3 | 3 3.0|
Hyperplasia, Lymphoid | 3 2 | 3 2.7|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
Atrophy | | 1 3.0|
Hematopoietic Cell Proliferation | 3 3 3 3 3 2 2 4 3 2 | 15 2.8|
Hyperplasia, Lymphoid | 3 | 2 3.0|
|__________________________________________________________________________|____________|
Thymus | + I + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Cyst | 2 | 2 2.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M + M M M M M M M M M M M M M| 1 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | | 1 3.0|
Epidermis, Hyperplasia, Focal | 1 | 1 1.0|
Site of Application - Dermis, | | |
Inflammation, Focal | 2 | 2 2.0|
Site of Application - Epidermis, | | |
Hyperplasia | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| |
DAY ON TEST | 3| 9| 3| 1| 3| 7| 3| 3| 3| 3| 4| 2| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 9| |
| 1| 2| 0| 5| 0| 2| 1| 1| 2| 2| 0| 1| 9| 0| 0| 0| 0| 0| 1| 1| 7| 2| 0| 0| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | | 2 2.0|
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
|__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
|__________________________________________________________________________|____________|
Spinal Cord | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 2.0|
Hyperplasia, Histiocytic | | 1 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
Inflammation, Chronic, Focal | | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 1 1 | 4 1.3|
Mediastinum, Hyperplasia, Lymphoid | | 1 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
Inflammation | 2 | 2 2.5|
Nasolacrimal Duct, Hyperplasia, Focal| | 1 2.0|
Nasolacrimal Duct, Inflammation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
__________________________________________________________________________________________________________________________________
| 7| 5| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| |
DAY ON TEST | 3| 9| 3| 1| 3| 7| 3| 3| 3| 3| 4| 2| 2| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 9| |
| 1| 2| 0| 5| 0| 2| 1| 1| 2| 2| 0| 1| 9| 0| 0| 0| 0| 0| 1| 1| 7| 2| 0| 0| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
Eye | + A + + + + + + + + A + + + + + + + + + + + + + A| 46 |
Atrophy | | 1 4.0|
Inflammation | | 1 2.0|
Cornea, Inflammation, Chronic | 3 | 2 2.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 4 | 1 4.0|
Epithelium, Hyperplasia, Focal | 2 2 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + A + + + + + + + + + + + + + + + + + + + + + + A| 48 |
Cyst | 1 | 3 1.7|
Hydronephrosis | 3 2 | 2 2.5|
Infarct | 1 2 | 2 1.5|
Metaplasia, Focal, Osseous | 2 1 2 | 4 1.8|
Nephropathy | 1 2 1 2 1 2 3 1 1 1 1 1 2 1 2 2 1 1 1 2 1 | 46 1.4|
Renal Tubule, Hyperplasia, Focal | | 2 1.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 0| 7| 7| 7| 6| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 9| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 3| 5| 3| 2| 2| 7| 2| 1| 3| 0| 3|
| 0| 1| 0| 1| 2| 1| 1| 1| 0| 9| 2| 0| 9| 1| 5| 4| 1| 9| 9| 0| 9| 0| 2| 3| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
10 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + A + + + + + + + + + + + + I + + + + + + A + + +|
Cyst | |
Epithelium, Degeneration, Hyaline | 3 |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + A + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + + + + + + A + + + + + + A + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + A + + +|
Ectopic Tissue | |
|__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + A + + + + + + A + + +|
Inflammation, Focal | 3 |
Peyer's Patch, Hyperplasia, Lymphoid | 3 |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + + A + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | X |
Eosinophilic Focus | |
Hyperplasia, Focal, Histiocytic | 3 |
Infiltration Cellular, Mixed Cell | 3 1 |
Pigmentation, Focal | 3 |
Hepatocyte, Clear Cell Focus | X X X X X X X X |
Hepatocyte, Mixed Cell Focus | X |
Hepatocyte, Necrosis, Focal | 1 3 |
Hepatocyte, Vacuolization Cytoplasmic| 2 2 3 3 2 2 2 2 |
|__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 3 |
Artery, Inflammation | 3 |
Fat, Necrosis, Focal | 3 3 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 65
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 0| 7| 7| 7| 6| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 9| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 3| 5| 3| 2| 2| 7| 2| 1| 3| 0| 3|
| 0| 1| 0| 1| 2| 1| 1| 1| 0| 9| 2| 0| 9| 1| 5| 4| 1| 9| 9| 0| 9| 0| 2| 3| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
10 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis, Focal | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Ulcer | |
Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Stomach, Glandular | + A + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
|__________________________________________________________________________|
Tooth | + + + + + + + + + |
Malformation | 2 3 2 3 2 2 3 3 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | 4 |
Artery, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 |
Cytoplasmic Alteration, Focal | 1 1 |
Hyperplasia, Focal, Histiocytic | 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
__________________________________________|__________________________________________________________________________|
Page 66
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 0| 7| 7| 7| 6| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 9| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 3| 5| 3| 2| 2| 7| 2| 1| 3| 0| 3|
| 0| 1| 0| 1| 2| 1| 1| 1| 0| 9| 2| 0| 9| 1| 5| 4| 1| 9| 9| 0| 9| 0| 2| 3| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
10 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | |
Follicle, Degeneration, Cystic, Focal| 2 3 2 2 |
Follicular Cell, Hyperplasia, Focal | 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Peritoneum | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Spermatocele | 3 |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 |
Hyperplasia, Lymphoid | 4 |
Inflammation, Chronic | 3 3 4 3 |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 4 |
Epithelium, Hyperplasia, Focal | 2 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 3 3 3 3 3 3|
|__________________________________________________________________________|
Lymph Node | + + |
Bronchial, Hyperplasia, Lymphoid | |
Inguinal, Hyperplasia, Lymphoid | 3 |
__________________________________________|__________________________________________________________________________|
Page 67
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 0| 7| 7| 7| 6| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 9| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 3| 5| 3| 2| 2| 7| 2| 1| 3| 0| 3|
| 0| 1| 0| 1| 2| 1| 1| 1| 0| 9| 2| 0| 9| 1| 5| 4| 1| 9| 9| 0| 9| 0| 2| 3| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
10 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Pancreatic, Hyperplasia, Lymphoid | 3 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 |
Hemorrhage | 3 |
Hyperplasia, Lymphoid | 3|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 3 3 3 3 |
Hyperplasia, Lymphoid | 2 2 2 3 3 |
|__________________________________________________________________________|
Thymus | + M + + + + + + + + + + + + + + + M I + + + I + +|
Cyst | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Site of Application - Dermis, | |
Inflammation, Focal | 1 3 |
Site of Application - Epidermis, | |
Hyperplasia | 3 |
Site of Application, Ulcer | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 |
|__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 68
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
_____________________________________________________________________________________________________________________
| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 0| 7| 7| 7| 6| 7| 7| 7| 6| 7|
DAY ON TEST | 3| 9| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 3| 5| 3| 2| 2| 7| 2| 1| 3| 0| 3|
| 0| 1| 0| 1| 2| 1| 1| 1| 0| 9| 2| 0| 9| 1| 5| 4| 1| 9| 9| 0| 9| 0| 2| 3| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
10 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Histiocytic | 1 |
Hyperplasia, Lymphoid | 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Cyst | |
Nasolacrimal Duct, Hyperplasia, Focal| 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + A + + + + + + + + + + + + + + + + + + + A + + +|
Cornea, Hyperplasia, Squamous | |
Cornea, Inflammation, Chronic | 2 |
Cornea, Necrosis, Focal | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic, Focal | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 2 2 |
Hydronephrosis | |
Infarct | 2 2 |
Metaplasia, Focal, Osseous | 2 |
Nephropathy | 2 1 1 2 2 2 2 1 3 1 2 1 2 1 2 2 4 2 1 1 1 2 2|
Renal Tubule, Hyperplasia, Focal | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 3 |
__________________________________________|__________________________________________________________________________
Page 69
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 0| 3| 6| 3| 2| 3| 4| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 2| |
| 2| 0| 0| 9| 1| 1| 1| 1| 2| 0| 2| 9| 0| 5| 0| 2| 0| 6| 2| 0| 1| 0| 2| 2| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
10 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + + I + + + A + A + + + A + + + A + + + + + + +| 42 |
Cyst | 2 | 1 2.0|
Epithelium, Degeneration, Hyaline | | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + A + A + + + + + + + A + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + A + A + + + + + + + A + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + A + A + + + A + + + A + + + + + + +| 43 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + A + A + + + A + + + A + + + + + + +| 44 |
Ectopic Tissue | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + A + A + + + A + + + A + + + + + + +| 43 |
Inflammation, Focal | | 1 3.0|
Peyer's Patch, Hyperplasia, Lymphoid | | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + A + A + + + A + + + A + + + + + + +| 44 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Clear Cell Focus | | 1 |
Eosinophilic Focus | X | 1 |
Hyperplasia, Focal, Histiocytic | | 1 3.0|
Infiltration Cellular, Mixed Cell | 1 1 1 | 5 1.4|
Pigmentation, Focal | | 1 3.0|
Hepatocyte, Clear Cell Focus | X X X X X X X X X | 17 |
Hepatocyte, Mixed Cell Focus | X | 2 |
Hepatocyte, Necrosis, Focal | 3 | 3 2.3|
Hepatocyte, Vacuolization Cytoplasmic| 2 1 2 2 2 1 2 2 2 | 17 2.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 0| 3| 6| 3| 2| 3| 4| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 2| |
| 2| 0| 0| 9| 1| 1| 1| 1| 2| 0| 2| 9| 0| 5| 0| 2| 0| 6| 2| 0| 1| 0| 2| 2| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
10 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Inflammation | | 1 3.0|
Artery, Inflammation | | 1 3.0|
Fat, Necrosis, Focal | | 2 3.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis, Focal | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | | 1 2.0|
Ulcer | 2 | 1 2.0|
Epithelium, Hyperplasia | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + A + + + + + + + + + A + + + + + + +| 47 |
Erosion | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Tooth | + +| 11 |
Malformation | 2 2| 11 2.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Thrombosis | | 1 4.0|
Artery, Inflammation, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 2 | 2 1.5|
Cytoplasmic Alteration, Focal | 1 1 2 | 5 1.2|
Hyperplasia, Focal, Histiocytic | | 1 2.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 0| 3| 6| 3| 2| 3| 4| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 2| |
| 2| 0| 0| 9| 1| 1| 1| 1| 2| 0| 2| 9| 0| 5| 0| 2| 0| 6| 2| 0| 1| 0| 2| 2| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
10 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 2 2.5|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + I + I + + + + + + + I + + + + + + +| 47 |
Cyst | 1 | 2 1.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 2 2 | 3 1.7|
Follicle, Degeneration, Cystic, Focal| 2 2 | 6 2.2|
Follicular Cell, Hyperplasia, Focal | 2 1 1 1 1 | 7 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Spermatocele | | 1 3.0|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | | 1 3.0|
Hyperplasia, Lymphoid | | 1 4.0|
Inflammation, Chronic | 4 3 3 3| 8 3.3|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 1 4.0|
Epithelium, Hyperplasia, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 0| 3| 6| 3| 2| 3| 4| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 2| |
| 2| 0| 0| 9| 1| 1| 1| 1| 2| 0| 2| 9| 0| 5| 0| 2| 0| 6| 2| 0| 1| 0| 2| 2| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
10 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 3 2 3 3 | 13 2.9|
|__________________________________________________________________________|____________|
Lymph Node | + + + | 5 |
Bronchial, Hyperplasia, Lymphoid | 3 | 1 3.0|
Inguinal, Hyperplasia, Lymphoid | 3 3 | 3 3.0|
Pancreatic, Hyperplasia, Lymphoid | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + M + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + I + + + + + + + + + + + + + + + + I| 48 |
Hematopoietic Cell Proliferation | | 1 3.0|
Hemorrhage | | 1 3.0|
Hyperplasia, Lymphoid | 3 | 2 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 2 3 2 2 3 2| 13 2.6|
Hyperplasia, Lymphoid | | 5 2.4|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + M + + + + + + I + + + +| 44 |
Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 0| 3| 6| 3| 2| 3| 4| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 2| |
| 2| 0| 0| 9| 1| 1| 1| 1| 2| 0| 2| 9| 0| 5| 0| 2| 0| 6| 2| 0| 1| 0| 2| 2| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
10 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Site of Application - Dermis, | | |
Inflammation, Focal | | 2 2.0|
Site of Application - Epidermis, | | |
Hyperplasia | 2 2 | 3 2.3|
Site of Application, Ulcer | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Skeletal Muscle | + + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Histiocytic | | 1 1.0|
Hyperplasia, Lymphoid | | 1 1.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 1 2 | 2 1.5|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nasolacrimal Duct, Cyst | 2 | 1 2.0|
Nasolacrimal Duct, Hyperplasia, Focal| 2 | 2 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + A + A + + + + + + + + + + + + + + +| 46 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 2| 3| 3| 3| 0| 3| 6| 3| 2| 3| 4| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 2| |
| 2| 0| 0| 9| 1| 1| 1| 1| 2| 0| 2| 9| 0| 5| 0| 2| 0| 6| 2| 0| 1| 0| 2| 2| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
10 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
Cornea, Hyperplasia, Squamous | 2 | 1 2.0|
Cornea, Inflammation, Chronic | 3 2 | 3 2.3|
Cornea, Necrosis, Focal | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + A + A + + + + + + + + + + + + + + +| 48 |
Cyst | 2 2 2 2 2 2 | 10 2.0|
Hydronephrosis | 3 | 1 3.0|
Infarct | 2 | 3 2.0|
Metaplasia, Focal, Osseous | 2 | 2 2.0|
Nephropathy | 2 2 1 1 1 1 2 1 2 1 1 1 1 1 1 2 1 2 2 1 2| 44 1.6|
Renal Tubule, Hyperplasia, Focal | 1 2 2| 3 1.7|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 0| 0| 7| 6|
DAY ON TEST | 3| 1| 3| 3| 2| 3| 3| 2| 3| 3| 3| 2| 3| 2| 5| 3| 6| 2| 3| 3| 2| 4| 5| 2| 8|
| 0| 3| 1| 0| 5| 1| 0| 9| 1| 1| 2| 9| 1| 9| 3| 1| 9| 9| 0| 0| 9| 8| 5| 9| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
20 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + A + + + + + + + + + M + + + + A + + + + + A + A|
Cyst | 1 |
Epithelium, Degeneration, Hyaline | 3 |
Epithelium, Hyperplasia | 3 |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + + + + + + + + + + + A + + + + A + + A|
|__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + + + + + + + + + + + A + + + + A + + A|
|__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + + + + + + + + + + + A + + + + A + + A|
Inflammation, Focal | 2 |
|__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + + + + + + + + + + + A + + + + A + + A|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | X |
Eosinophilic Focus | X |
Infarct | |
Infiltration Cellular, Mixed Cell | 1 3 1 |
Thrombosis | 4|
Bile Duct, Hyperplasia | |
Hepatocyte, Clear Cell Focus | X X X X X |
Hepatocyte, Necrosis, Focal | 2 |
Hepatocyte, Vacuolization Cytoplasmic| 2 2 2 2 |
|__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | 2 |
Fat, Necrosis, Focal | 2 1 2 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal | 2 |
__________________________________________|__________________________________________________________________________|
Page 76
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 0| 0| 7| 6|
DAY ON TEST | 3| 1| 3| 3| 2| 3| 3| 2| 3| 3| 3| 2| 3| 2| 5| 3| 6| 2| 3| 3| 2| 4| 5| 2| 8|
| 0| 3| 1| 0| 5| 1| 0| 9| 1| 1| 2| 9| 1| 9| 3| 1| 9| 9| 0| 0| 9| 8| 5| 9| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
20 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Necrosis, Focal | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Focal | 2 |
Epithelium, Hyperplasia | 1 2 |
|__________________________________________________________________________|
Stomach, Glandular | + A + + + + + + + + + + + + + + + + + + + + + + A|
Erosion | 1 |
|__________________________________________________________________________|
Tooth | + + + + + + |
Malformation | 2 3 2 3 3 3 |
Peridontal Tissue, Inflammation, | |
Chronic | |
Pulp, Inflammation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2|
Inflammation, Chronic, Focal | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 1 |
Cytoplasmic Alteration, Focal | 1 1 1 |
Hypertrophy | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________|__________________________________________________________________________|
Page 77
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 0| 0| 7| 6|
DAY ON TEST | 3| 1| 3| 3| 2| 3| 3| 2| 3| 3| 3| 2| 3| 2| 5| 3| 6| 2| 3| 3| 2| 4| 5| 2| 8|
| 0| 3| 1| 0| 5| 1| 0| 9| 1| 1| 2| 9| 1| 9| 3| 1| 9| 9| 0| 0| 9| 8| 5| 9| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
20 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
|__________________________________________________________________________|
Parathyroid Gland | + M + + + I + + + + + + + + + + + + + + + + + + +|
Cyst | 2 3 |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Pars Distalis, Cytoplasmic | |
Alteration, Focal | 2 1 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Degeneration, Cystic, Focal| 2 2 2 3 2|
Follicular Cell, Hyperplasia, Focal | 2 2 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Peritoneum | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tissue NOS | + |
Abdominal, Cyst | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 3 |
Inflammation, Chronic | 2 |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
Inflammation, Chronic | 3 3 3 1 3 |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Interstitial Cell, Hyperplasia, Focal| |
__________________________________________|__________________________________________________________________________|
Page 78
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 0| 0| 7| 6|
DAY ON TEST | 3| 1| 3| 3| 2| 3| 3| 2| 3| 3| 3| 2| 3| 2| 5| 3| 6| 2| 3| 3| 2| 4| 5| 2| 8|
| 0| 3| 1| 0| 5| 1| 0| 9| 1| 1| 2| 9| 1| 9| 3| 1| 9| 9| 0| 0| 9| 8| 5| 9| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
20 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 2 3 3 |
|__________________________________________________________________________|
Lymph Node | + + + |
Inguinal, Hyperplasia, Lymphoid | 2 3 |
Mediastinal, Hyperplasia, Lymphoid | 2 |
Pancreatic, Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 |
Hemorrhage | 3 3|
Hyperplasia, Lymphoid | 3 3 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Hematopoietic Cell Proliferation | 3 3 3 4 2 3 3|
Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + I + + + + + + + + + + + I|
Cyst | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epidermis, Hyperplasia, Focal | 1 |
Site of Application - Dermis, | |
Inflammation, Focal | 1 1 2 2 1 3 1 1 |
Site of Application - Epidermis, | |
Hyperplasia | 2 2 2 2 2 1 2 2 |
Site of Application, Ulcer | 3 |
Subcutaneous Tissue, Angiectasis, | |
Focal | 3 |
Subcutaneous Tissue, Inflammation, | |
__________________________________________|__________________________________________________________________________|
Page 79
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 0| 0| 7| 6|
DAY ON TEST | 3| 1| 3| 3| 2| 3| 3| 2| 3| 3| 3| 2| 3| 2| 5| 3| 6| 2| 3| 3| 2| 4| 5| 2| 8|
| 0| 3| 1| 0| 5| 1| 0| 9| 1| 1| 2| 9| 1| 9| 3| 1| 9| 9| 0| 0| 9| 8| 5| 9| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
20 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
Chronic, Focal | 3 |
Subcutaneous Tissue, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 1 |
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | |
|__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hyperplasia, Histiocytic | |
Alveolar Epithelium, Hyperplasia, | |
Focal | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Nasolacrimal Duct, Hyperplasia, Focal| 3 |
Nasolacrimal Duct, Inflammation | 3 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + A + + + + + + + + + + + + + + A + + + + + + + +|
Cornea, Inflammation, Chronic | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 80
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 0| 0| 7| 6|
DAY ON TEST | 3| 1| 3| 3| 2| 3| 3| 2| 3| 3| 3| 2| 3| 2| 5| 3| 6| 2| 3| 3| 2| 4| 5| 2| 8|
| 0| 3| 1| 0| 5| 1| 0| 9| 1| 1| 2| 9| 1| 9| 3| 1| 9| 9| 0| 0| 9| 8| 5| 9| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
20 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia, Focal | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Infarct | |
Infiltration Cellular, Mixed Cell | 2 |
Metaplasia, Focal, Osseous | |
Nephropathy | 1 2 2 1 2 2 2 1 2 1 1 2 2 2 1 1 2 2 1 3|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 81
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 5| |
DAY ON TEST | 3| 3| 2| 2| 3| 3| 2| 3| 2| 3| 3| 9| 3| 3| 3| 3| 9| 2| 1| 9| 3| 3| 3| 3| 9| |
| 1| 0| 9| 9| 1| 2| 9| 0| 9| 2| 0| 6| 1| 2| 1| 1| 3| 9| 5| 0| 1| 1| 1| 1| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
20 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + I + + + + + + + A| 43 |
Cyst | 2 | 2 1.5|
Epithelium, Degeneration, Hyaline | | 1 3.0|
Epithelium, Hyperplasia | | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + + + + + + + A| 44 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A + + + + + + + A| 44 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A + + + + + + + A| 44 |
Inflammation, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + A + + + + + + + A| 44 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Clear Cell Focus | | 1 |
Eosinophilic Focus | | 1 |
Infarct | 3 | 1 3.0|
Infiltration Cellular, Mixed Cell | 1 1 | 5 1.4|
Thrombosis | | 1 4.0|
Bile Duct, Hyperplasia | 3 | 1 3.0|
Hepatocyte, Clear Cell Focus | X X X X X X X | 12 |
Hepatocyte, Necrosis, Focal | 3 | 2 2.5|
Hepatocyte, Vacuolization Cytoplasmic| 2 2 3 1 2 3 1 2 1 3 2 2 1 | 17 1.9|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 82
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 5| |
DAY ON TEST | 3| 3| 2| 2| 3| 3| 2| 3| 2| 3| 3| 9| 3| 3| 3| 3| 9| 2| 1| 9| 3| 3| 3| 3| 9| |
| 1| 0| 9| 9| 1| 2| 9| 0| 9| 2| 0| 6| 1| 2| 1| 1| 3| 9| 5| 0| 1| 1| 1| 1| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
20 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Fat, Necrosis, Focal | 3 | 4 2.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
Inflammation, Focal | | 1 2.0|
Necrosis, Focal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 3.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Focal | | 1 2.0|
Epithelium, Hyperplasia | 2 | 3 1.7|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Erosion | | 1 1.0|
|__________________________________________________________________________|____________|
Tooth | + + + + + + + + + | 15 |
Malformation | 3 2 1 2 3 3 3 3 2 | 15 2.5|
Peridontal Tissue, Inflammation, | | |
Chronic | 2 | 1 2.0|
Pulp, Inflammation | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + | 2 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | | 1 2.0|
Inflammation, Chronic, Focal | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 2 | 2 1.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 83
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 5| |
DAY ON TEST | 3| 3| 2| 2| 3| 3| 2| 3| 2| 3| 3| 9| 3| 3| 3| 3| 9| 2| 1| 9| 3| 3| 3| 3| 9| |
| 1| 0| 9| 9| 1| 2| 9| 0| 9| 2| 0| 6| 1| 2| 1| 1| 3| 9| 5| 0| 1| 1| 1| 1| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
20 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Cytoplasmic Alteration, Focal | 1 2 1 3 | 7 1.4|
Hypertrophy | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | | 1 2.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
Hyperplasia | 3 | 2 2.5|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + M + + + + + + + + + + + + + + + + + +| 46 |
Cyst | | 2 2.5|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 2 | 3 1.7|
Pars Distalis, Cytoplasmic | | |
Alteration, Focal | 1 2 1 | 5 1.4|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicle, Degeneration, Cystic, Focal| 1 1 1 | 8 1.8|
Follicular Cell, Hyperplasia, Focal | 2 1 1 | 8 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Tissue NOS | + +| 3 |
Abdominal, Cyst | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | | 1 3.0|
Inflammation, Chronic | | 1 2.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 84
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 5| |
DAY ON TEST | 3| 3| 2| 2| 3| 3| 2| 3| 2| 3| 3| 9| 3| 3| 3| 3| 9| 2| 1| 9| 3| 3| 3| 3| 9| |
| 1| 0| 9| 9| 1| 2| 9| 0| 9| 2| 0| 6| 1| 2| 1| 1| 3| 9| 5| 0| 1| 1| 1| 1| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
20 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 3| 1 3.0|
Inflammation, Chronic | 3 3 4 3 3 | 10 2.9|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 2.0|
Interstitial Cell, Hyperplasia, Focal| 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 3 3 3 3 3 3 | 12 2.9|
|__________________________________________________________________________|____________|
Lymph Node | + + | 5 |
Inguinal, Hyperplasia, Lymphoid | 3 3 | 4 2.8|
Mediastinal, Hyperplasia, Lymphoid | | 1 2.0|
Pancreatic, Hyperplasia, Lymphoid | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + M M + + + + + + + + + + + + + M| 47 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
Ectasia | | 1 3.0|
Hemorrhage | 3 | 3 3.0|
Hyperplasia, Lymphoid | 3 3 | 4 3.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 2.0|
Hematopoietic Cell Proliferation | 3 2 3 2 3 2 3| 14 2.8|
Hyperplasia, Lymphoid | 2 | 1 2.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 85
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 5| |
DAY ON TEST | 3| 3| 2| 2| 3| 3| 2| 3| 2| 3| 3| 9| 3| 3| 3| 3| 9| 2| 1| 9| 3| 3| 3| 3| 9| |
| 1| 0| 9| 9| 1| 2| 9| 0| 9| 2| 0| 6| 1| 2| 1| 1| 3| 9| 5| 0| 1| 1| 1| 1| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
20 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Thymus | + + + + + + + + + + I + + + + + + + + + + + + + +| 47 |
Cyst | 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epidermis, Hyperplasia, Focal | | 1 1.0|
Site of Application - Dermis, | | |
Inflammation, Focal | 1 | 9 1.4|
Site of Application - Epidermis, | | |
Hyperplasia | 2 1 | 10 1.8|
Site of Application, Ulcer | | 1 3.0|
Subcutaneous Tissue, Angiectasis, | | |
Focal | | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic, Focal | | 1 3.0|
Subcutaneous Tissue, Thrombosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | | 1 1.0|
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + | 1 |
|__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 86
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 5| |
DAY ON TEST | 3| 3| 2| 2| 3| 3| 2| 3| 2| 3| 3| 9| 3| 3| 3| 3| 9| 2| 1| 9| 3| 3| 3| 3| 9| |
| 1| 0| 9| 9| 1| 2| 9| 0| 9| 2| 0| 6| 1| 2| 1| 1| 3| 9| 5| 0| 1| 1| 1| 1| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
20 MG/KG | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | 3| 1 3.0|
Hyperplasia, Histiocytic | 3 3 3 3 | 4 3.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 2 | 1 2.0|
Nasolacrimal Duct, Hyperplasia, Focal| | 1 3.0|
Nasolacrimal Duct, Inflammation | 3| 2 3.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + A + + + + + + + +| 47 |
Cornea, Inflammation, Chronic | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Hyperplasia, Focal | 1 2 | 3 1.7|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 2 2 2 2 | 5 2.0|
Infarct | 2 | 1 2.0|
Infiltration Cellular, Mixed Cell | | 1 2.0|
Metaplasia, Focal, Osseous | 1 | 1 1.0|
Nephropathy | 2 2 1 1 1 2 2 2 1 1 1 2 1 1 1 2 2 1 2 2 2 | 41 1.6|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 87
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 6| 7| 3| 3| 3| 7| 7| 3| 3| 3| 3| 2| 7| 2| 3| 8| 3| 3| 3| 3| 2| 3| 4| 3| 3|
| 4| 4| 0| 1| 1| 3| 9| 0| 1| 0| 0| 9| 4| 9| 0| 4| 0| 0| 2| 2| 9| 2| 2| 0| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
40 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | M A + + + + A + + + + + M + + I + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | A + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | A + + + + A + + + + + + A + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | A A + + + + A + I + + + A + + + + + + + + + + + +|
Serosa, Inflammation, Chronic | |
|__________________________________________________________________________|
Intestine Small, Jejunum | A A + + + A A + + + + + A + + + + + + + + + + + +|
Cyst | |
Peyer's Patch, Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Intestine Small, Ileum | A A + + + A A + + + + + A + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Clear Cell Focus | X |
Eosinophilic Focus | X |
Hemorrhage, Focal | |
Hepatodiaphragmatic Nodule | 2 |
Infarct | 4|
Infiltration Cellular, Mixed Cell | 3 1 1 1 1 |
Inflammation, Focal, Granulomatous | |
Capsule, Inflammation, Chronic | |
Hepatocyte, Clear Cell Focus | X X |
Hepatocyte, Mixed Cell Focus | X X |
Hepatocyte, Necrosis, Focal | 2 1 1 2 1 |
Hepatocyte, Vacuolization Cytoplasmic| 2 2 2 3 3 2 1 3 |
|__________________________________________________________________________|
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Inflammation | 3|
Fat, Necrosis, Focal | 2 2 |
__________________________________________|__________________________________________________________________________|
Page 88
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 6| 7| 3| 3| 3| 7| 7| 3| 3| 3| 3| 2| 7| 2| 3| 8| 3| 3| 3| 3| 2| 3| 4| 3| 3|
| 4| 4| 0| 1| 1| 3| 9| 0| 1| 0| 0| 9| 4| 9| 0| 4| 0| 0| 2| 2| 9| 2| 2| 0| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
40 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + A + + + + + + + + + + + +|
Acinus, Atrophy, Focal | 3 3 |
Serosa, Inflammation, Chronic | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | 2 |
Inflammation, Focal | |
Epithelium, Cyst | 1 |
Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + A + + + + + + + + + + + +|
|__________________________________________________________________________|
Tooth | + + + + + + +|
Malformation | 2 3 2 3 3 3 3|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 |
Infiltration Cellular, Mixed Cell | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | I + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 3 |
Cytoplasmic Alteration, Focal | 1|
Degeneration, Cystic | |
|__________________________________________________________________________|
Adrenal Medulla | I + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + M + + + + + + M + + + + + + + + + + + +|
Cyst | |
__________________________________________|__________________________________________________________________________|
Page 89
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 6| 7| 3| 3| 3| 7| 7| 3| 3| 3| 3| 2| 7| 2| 3| 8| 3| 3| 3| 3| 2| 3| 4| 3| 3|
| 4| 4| 0| 1| 1| 3| 9| 0| 1| 0| 0| 9| 4| 9| 0| 4| 0| 0| 2| 2| 9| 2| 2| 0| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
40 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicle, Degeneration, Cystic, Focal| 2 2 |
Follicular Cell, Hyperplasia, Focal | 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Peritoneum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tissue NOS | + |
Hemorrhage | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 2 |
Inflammation, Chronic | |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 3 3 |
Degeneration, Cystic | |
Inflammation, Chronic | 3 4 3 |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 3 3 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 3 2 2 |
Thrombosis | 1|
__________________________________________|__________________________________________________________________________|
Page 90
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 6| 7| 3| 3| 3| 7| 7| 3| 3| 3| 3| 2| 7| 2| 3| 8| 3| 3| 3| 3| 2| 3| 4| 3| 3|
| 4| 4| 0| 1| 1| 3| 9| 0| 1| 0| 0| 9| 4| 9| 0| 4| 0| 0| 2| 2| 9| 2| 2| 0| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
40 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Lymph Node | + |
Iliac, Hyperplasia, Lymphoid | |
Inguinal, Hyperplasia, Lymphoid | |
Pancreatic, Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + M + + M + + + + + + + + + + + + + + +|
Hyperplasia, Histiocytic | 2 |
Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 4 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + M + + +|
Fibrosis, Focal | |
Hematopoietic Cell Proliferation | 3 2 3 3 3 2 2|
Hyperplasia, Lymphoid | |
Thrombosis | 3 |
Capsule, Inflammation, Chronic | |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + I + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Site of Application - Dermis, | |
Inflammation, Focal | |
Site of Application - Epidermis, | |
Hyperplasia | |
Subcutaneous Tissue, Edema | |
Subcutaneous Tissue, Site of | |
Application, Infiltration | |
Cellular | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 91
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 6| 7| 3| 3| 3| 7| 7| 3| 3| 3| 3| 2| 7| 2| 3| 8| 3| 3| 3| 3| 2| 3| 4| 3| 3|
| 4| 4| 0| 1| 1| 3| 9| 0| 1| 0| 0| 9| 4| 9| 0| 4| 0| 0| 2| 2| 9| 2| 2| 0| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
40 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + + |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + + + |
|__________________________________________________________________________|
Spinal Cord | + + |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 2|
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nasolacrimal Duct, Inflammation | 2 1 2 |
|__________________________________________________________________________|
Pleura | + |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + A + + + + + + + + + + A + + + + + + + + + + + +|
Cornea, Hyperplasia, Squamous | 1 |
Cornea, Inflammation, Chronic | 3 3 |
Cornea, Necrosis, Focal | 3 |
Retrobulbar, Inflammation | 2 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Epithelium, Hyperplasia, Focal | |
__________________________________________|__________________________________________________________________________|
Page 92
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
_____________________________________________________________________________________________________________________
| 6| 4| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 6| 7| 3| 3| 3| 7| 7| 3| 3| 3| 3| 2| 7| 2| 3| 8| 3| 3| 3| 3| 2| 3| 4| 3| 3|
| 4| 4| 0| 1| 1| 3| 9| 0| 1| 0| 0| 9| 4| 9| 0| 4| 0| 0| 2| 2| 9| 2| 2| 0| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
40 MG/KG | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | A + + + + + + + + + + + A + + + + + + + + + + + +|
Cyst | 2 1 2 |
Infarct | 2 |
Inflammation | 3 |
Nephropathy | 1 1 1 2 3 1 2 1 1 1 1 1 1 1 1 1 1 1 3|
Pelvis, Dilatation | |
Renal Tubule, Hyperplasia, Focal | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 3 3 |
__________________________________________|__________________________________________________________________________
Page 93
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 6| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7| |
DAY ON TEST | 2| 3| 1| 3| 9| 6| 4| 3| 2| 2| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 1| 3| 3| 5| 2| |
| 9| 0| 0| 2| 8| 7| 8| 0| 9| 9| 2| 0| 0| 1| 1| 9| 1| 0| 9| 1| 2| 0| 2| 8| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
40 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + A A A + + + + + + + + + + + + + A + + + +| 41 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + A + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + A + + + + + + + + + + + + + + A + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A A A + + + + + + + + + + + + A A + + + +| 42 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A A A + + + + + + + + + + + + A A + + + +| 40 |
Serosa, Inflammation, Chronic | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A A A + + + + + + + + + + + + A A + + + +| 40 |
Cyst | 3 | 1 3.0|
Peyer's Patch, Hyperplasia, Lymphoid | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A A A + + + + + + + + + + + + A A + + + +| 40 |
|__________________________________________________________________________|____________|
Liver | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Clear Cell Focus | X | 2 |
Eosinophilic Focus | X X X | 4 |
Hemorrhage, Focal | 3 | 1 3.0|
Hepatodiaphragmatic Nodule | | 1 2.0|
Infarct | | 1 4.0|
Infiltration Cellular, Mixed Cell | 1 | 6 1.3|
Inflammation, Focal, Granulomatous | 3 | 1 3.0|
Capsule, Inflammation, Chronic | 3 | 1 3.0|
Hepatocyte, Clear Cell Focus | X X X X X X | 8 |
Hepatocyte, Mixed Cell Focus | | 2 |
Hepatocyte, Necrosis, Focal | 3 3 | 7 1.9|
Hepatocyte, Vacuolization Cytoplasmic| 3 3 3 2 2 1 2 2 3 1 | 18 2.2|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 94
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 6| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7| |
DAY ON TEST | 2| 3| 1| 3| 9| 6| 4| 3| 2| 2| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 1| 3| 3| 5| 2| |
| 9| 0| 0| 2| 8| 7| 8| 0| 9| 9| 2| 0| 0| 1| 1| 9| 1| 0| 9| 1| 2| 0| 2| 8| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
40 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Mesentery | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 3 | 1 3.0|
Inflammation | | 1 3.0|
Fat, Necrosis, Focal | 2 2 | 4 2.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acinus, Atrophy, Focal | 2 | 3 2.7|
Serosa, Inflammation, Chronic | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Diverticulum | | 1 2.0|
Inflammation, Focal | 2 | 1 2.0|
Epithelium, Cyst | | 1 1.0|
Epithelium, Hyperplasia | 2 2 | 2 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + A + + + + + + + + + + + + + + A + + + +| 47 |
|__________________________________________________________________________|____________|
Tooth | + + + + + | 12 |
Malformation | 3 2 2 2 2 | 12 2.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | | 1 2.0|
Infiltration Cellular, Mixed Cell | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Accessory Adrenal Cortical Nodule | 1 | 2 2.0|
Cytoplasmic Alteration, Focal | 2 1 2 | 4 1.5|
Degeneration, Cystic | 1 | 1 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 95
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 6| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7| |
DAY ON TEST | 2| 3| 1| 3| 9| 6| 4| 3| 2| 2| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 1| 3| 3| 5| 2| |
| 9| 0| 0| 2| 8| 7| 8| 0| 9| 9| 2| 0| 0| 1| 1| 9| 1| 0| 9| 1| 2| 0| 2| 8| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
40 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| 47 |
Cyst | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + A + + + + + + + + + + + + + + + + + + +| 49 |
Cyst | 1 2 3 | 3 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Follicle, Degeneration, Cystic, Focal| 1 2 1 2| 6 1.7|
Follicular Cell, Hyperplasia, Focal | | 3 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Tissue NOS | + | 2 |
Hemorrhage | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | | 1 2.0|
Inflammation, Chronic | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 2 3.0|
Degeneration, Cystic | 3 3 3 3 | 4 3.0|
Inflammation, Chronic | 2 3 3 | 6 3.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 96
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 6| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7| |
DAY ON TEST | 2| 3| 1| 3| 9| 6| 4| 3| 2| 2| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 1| 3| 3| 5| 2| |
| 9| 0| 0| 2| 8| 7| 8| 0| 9| 9| 2| 0| 0| 1| 1| 9| 1| 0| 9| 1| 2| 0| 2| 8| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
40 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 2 3.0|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 3 3 | 7 2.9|
Thrombosis | | 1 1.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + | 4 |
Iliac, Hyperplasia, Lymphoid | 3 | 1 3.0|
Inguinal, Hyperplasia, Lymphoid | 3 | 1 3.0|
Pancreatic, Hyperplasia, Lymphoid | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | I + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia, Histiocytic | | 1 2.0|
Hyperplasia, Lymphoid | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + M + + + + + + + + + + + + + + + + + A + + + +| 48 |
Hyperplasia, Lymphoid | 3| 2 3.5|
|__________________________________________________________________________|____________|
Spleen | + + + + + A + + + + + + + + + + + + + + A + + + +| 47 |
Fibrosis, Focal | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 3 2 2 3 3 3 | 13 2.6|
Hyperplasia, Lymphoid | 3 | 1 3.0|
Thrombosis | | 1 3.0|
Capsule, Inflammation, Chronic | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + M M + + + + + + + + + + I + + + + + + +| 46 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 97
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 6| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7| |
DAY ON TEST | 2| 3| 1| 3| 9| 6| 4| 3| 2| 2| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 1| 3| 3| 5| 2| |
| 9| 0| 0| 2| 8| 7| 8| 0| 9| 9| 2| 0| 0| 1| 1| 9| 1| 0| 9| 1| 2| 0| 2| 8| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
40 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M + M M M M M M M M M M M M M M M M M M A M M M M| 1 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Site of Application - Dermis, | | |
Inflammation, Focal | 1 | 1 1.0|
Site of Application - Epidermis, | | |
Hyperplasia | 1 | 1 1.0|
Subcutaneous Tissue, Edema | 2 3 | 2 2.5|
Subcutaneous Tissue, Site of | | |
Application, Infiltration | | |
Cellular | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + | 5 |
Inflammation, Chronic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Peripheral Nerve | | 3 |
|__________________________________________________________________________|____________|
Spinal Cord | + | 3 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Alveolar Epithelium, Hyperplasia, | | |
Focal | 1 | 3 1.7|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 98
NTP Experiment-Test: 93020-08 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DIISOPROPYLCARBODIIMIDE Date: 07/19/04
Route: SKIN APPLICATION Time: 09:18:40
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 6| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7| |
DAY ON TEST | 2| 3| 1| 3| 9| 6| 4| 3| 2| 2| 3| 3| 3| 3| 3| 2| 3| 3| 2| 3| 1| 3| 3| 5| 2| |
| 9| 0| 0| 2| 8| 7| 8| 0| 9| 9| 2| 0| 0| 1| 1| 9| 1| 0| 9| 1| 2| 0| 2| 8| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
40 MG/KG | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nasolacrimal Duct, Inflammation | | 3 1.7|
|__________________________________________________________________________|____________|
Pleura | | 1 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + A A A + + + + + + + + + + + + + A + + + +| 44 |
Cornea, Hyperplasia, Squamous | | 1 1.0|
Cornea, Inflammation, Chronic | 2 | 3 2.7|
Cornea, Necrosis, Focal | | 1 3.0|
Retrobulbar, Inflammation | | 1 2.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1 | 1 1.0|
Epithelium, Hyperplasia, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Cyst | | 3 1.7|
Infarct | | 1 2.0|
Inflammation | 1 3 | 3 2.3|
Nephropathy | 2 1 2 1 1 1 1 1 1 1 1 1 2 1 2 2 1 1 2 3 1| 40 1.4|
Pelvis, Dilatation | 3 | 1 3.0|
Renal Tubule, Hyperplasia, Focal | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 2 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
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