TDMS Study 96018-04 Pathology Tables
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Southern Research Inst WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) DATE: 03/25/03
EXPERIMENT: 96018 TEST: 04 TIME: 11:07:23
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-85420 ROUTE: DOSED WATER NTP C#: C96018
PATHOLOGIST: HEATH, JAMES E. CAS: 75-27-4
------------------------------------------------------------------------------------------------------------------------------------
FINAL #1/MICE
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Southern Research Inst WATER DISINFECTION BYPRODUCTS (BROMODICHLOROMETHANE) DATE: 03/25/03
EXPERIMENT: 96018 TEST: 04 TIME: 11:07:23
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-85420 ROUTE: DOSED WATER NTP C#: C96018
PATHOLOGIST: HEATH, JAMES E. CAS: 75-27-4
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF WATER DISINFECTION BYPRODUCTS (BROMODICHL
===============================================================
Female Mice
------------
Organ Morphology
----- ----------
Bone Marrow Hyperplasia
Myelofibrosis
Brain Compression
Eye Developmental Malformation
Inflammation Chronic
Heart Mineralization
Intestine Large, Cecum Edema
Kidney Nephropathy
Liver Cyst
Infarct
Liver: Centrilobular Necrosis
Liver: Hepatocyte Karyomegaly
Liver: Kupffer Cell Pigmentation
Mammary Gland Hyperplasia
Ovary: Granulosa Cell Hyperplasia
Spleen Hematopoietic Cell Proliferation
Spleen: Lymphoid Follicle Hyperplasia
Thymus Atrophy
Thyroid Gland Degeneration Cystic
Thyroid Gland: Follicular Cell Hyperplasia
===============================================================
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 1
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Accessory Adrenal Cortical Nodule |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 8/50 (16%) 5/50 (10%) 5/49 (10%) 10/49 (20%) |
|POLY-3 RATE (b) | 8/46.30 5/43.54 5/42.79 10/45.20 |
|POLY-3 PERCENT (g) | 17.3% 11.5% 11.7% 22.1% |
|TERMINAL (d) | 4/36 (11%) 5/36 (14%) 3/32 (9%) 8/38 (21%) |
|FIRST INCIDENCE | 606 729 (T) 663 522 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.280 P=0.295N P=0.358N P=0.435 |
|POLY 3 | P=0.236 P=0.316N P=0.328N P=0.375 |
|POLY 1.5 | P=0.236 P=0.302N P=0.312N P=0.379 |
|POLY 6 | P=0.236 P=0.337N P=0.350N P=0.368 |
|LOGISTIC REGRESSION| P=0.235 P=0.301N P=0.308N P=0.379 |
|COCH-ARM / FISHERS | P=0.230 P=0.277N P=0.290N P=0.379 |
|ORDER RESTRICTED | P=0.199 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Hypertrophy Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/50 (2%) 1/50 (2%) 2/49 (4%) 0/49 (0%) |
|POLY-3 RATE (b) | 1/45.47 1/43.54 2/42.48 0/44.46 |
|POLY-3 PERCENT (g) | 2.2% 2.3% 4.7% 0.0% |
|TERMINAL (d) | 1/36 (3%) 1/36 (3%) 2/32 (6%) 0/38 (0%) |
|FIRST INCIDENCE | 729 (T) 729 (T) 729 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.357N P=0.762 P=0.459 P=0.489N |
|POLY 3 | P=0.370N P=0.751 P=0.476 P=0.504N |
|POLY 1.5 | P=0.371N P=0.754 P=0.483 P=0.504N |
|POLY 6 | P=0.370N P=0.747 P=0.468 P=0.505N |
|LOGISTIC REGRESSION| P=0.357N P=0.762 P=0.459 (e) |
|COCH-ARM / FISHERS | P=0.373N P=0.753N P=0.492 P=0.505N |
|ORDER RESTRICTED | P=0.261N (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 2
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Adrenal Cortex: Zona Reticularis |
| Vacuolization Cytoplasmic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 1/49 (2%) 0/49 (0%) |
|POLY-3 RATE (b) | 0/45.47 2/43.54 1/42.91 0/44.46 |
|POLY-3 PERCENT (g) | 0.0% 4.6% 2.3% 0.0% |
|TERMINAL (d) | 0/36 (0%) 2/36 (6%) 0/32 (0%) 0/38 (0%) |
|FIRST INCIDENCE | --- 729 (T) 604 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.455N P=0.238 P=0.491 (e) |
|POLY 3 | P=0.471N P=0.227 P=0.488 (e) |
|POLY 1.5 | P=0.469N P=0.231 P=0.491 (e) |
|POLY 6 | P=0.474N P=0.224 P=0.485 (e) |
|LOGISTIC REGRESSION| P=0.467N P=0.238 P=0.524 (e) |
|COCH-ARM / FISHERS | P=0.467N P=0.247 P=0.495 (e) |
|ORDER RESTRICTED | P=0.314 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 0/48 (0%) 0/49 (0%) 2/49 (4%) |
|POLY-3 RATE (b) | 2/45.47 0/42.17 0/42.48 2/44.60 |
|POLY-3 PERCENT (g) | 4.4% 0.0% 0.0% 4.5% |
|TERMINAL (d) | 2/36 (6%) 0/35 (0%) 0/32 (0%) 1/38 (3%) |
|FIRST INCIDENCE | 729 (T) --- --- 693 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.514 P=0.244N P=0.264N P=0.679N |
|POLY 3 | P=0.502 P=0.254N P=0.253N P=0.687 |
|POLY 1.5 | P=0.501 P=0.252N P=0.248N P=0.687 |
|POLY 6 | P=0.503 P=0.257N P=0.258N P=0.688 |
|LOGISTIC REGRESSION| P=0.498 (e) (e) P=0.687 |
|COCH-ARM / FISHERS | P=0.497 P=0.258N P=0.253N P=0.684 |
|ORDER RESTRICTED | P=0.272 (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 3
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Bone |
| Hyperostosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/50 (0%) 3/50 (6%) 1/50 (2%) 1/50 (2%) |
|POLY-3 RATE (b) | 0/45.47 3/43.54 1/43.97 1/45.46 |
|POLY-3 PERCENT (g) | 0.0% 6.9% 2.3% 2.2% |
|TERMINAL (d) | 0/36 (0%) 3/36 (8%) 0/33 (0%) 1/39 (3%) |
|FIRST INCIDENCE | --- 729 (T) 583 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.609 P=0.121 P=0.496 P=0.516 |
|POLY 3 | P=0.588 P=0.111 P=0.493 P=0.500 |
|POLY 1.5 | P=0.590 P=0.114 P=0.496 P=0.500 |
|POLY 6 | P=0.587 P=0.108 P=0.490 P=0.500 |
|LOGISTIC REGRESSION| P=0.592 P=0.121 P=0.532 P=0.516 |
|COCH-ARM / FISHERS | P=0.591 P=0.121 P=0.500 P=0.500 |
|ORDER RESTRICTED | P=0.213 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Bone Marrow |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 22/50 (44%) 24/50 (48%) 18/50 (36%) 11/50 (22%) |
|POLY-3 RATE (b) | 22/47.66 24/47.88 18/46.83 11/45.83 |
|POLY-3 PERCENT (g) | 46.2% 50.1% 38.4% 24.0% |
|TERMINAL (d) | 12/36 (33%) 15/36 (42%) 9/33 (27%) 9/39 (23%) |
|FIRST INCIDENCE | 563 318 486 669 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.008N** P=0.397 P=0.410N P=0.019N* |
|POLY 3 | P=0.006N** P=0.428 P=0.291N P=0.019N* |
|POLY 1.5 | P=0.005N** P=0.425 P=0.282N P=0.017N* |
|POLY 6 | P=0.008N** P=0.419 P=0.303N P=0.023N* |
|LOGISTIC REGRESSION| P=0.005N** P=0.446 P=0.258N P=0.016N* |
|COCH-ARM / FISHERS | P=0.005N** P=0.421 P=0.270N P=0.016N* |
|ORDER RESTRICTED | P=0.010N* (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 4
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Bone Marrow |
| Myelofibrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/50 (6%) 1/50 (2%) 1/50 (2%) 0/50 (0%) |
|POLY-3 RATE (b) | 3/45.65 1/43.54 1/43.71 0/45.46 |
|POLY-3 PERCENT (g) | 6.6% 2.3% 2.3% 0.0% |
|TERMINAL (d) | 1/36 (3%) 1/36 (3%) 0/33 (0%) 0/39 (0%) |
|FIRST INCIDENCE | 689 729 (T) 669 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.075N P=0.319N P=0.349N P=0.118N |
|POLY 3 | P=0.071N P=0.322N P=0.321N P=0.119N |
|POLY 1.5 | P=0.071N P=0.317N P=0.315N P=0.119N |
|POLY 6 | P=0.070N P=0.330N P=0.329N P=0.120N |
|LOGISTIC REGRESSION| P=0.073N P=0.324N P=0.312N P=0.120N |
|COCH-ARM / FISHERS | P=0.073N P=0.309N P=0.309N P=0.121N |
|ORDER RESTRICTED | P=0.037N* (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Brain |
| Compression |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|POLY-3 RATE (b) | 2/45.47 0/43.54 0/43.48 0/45.46 |
|POLY-3 PERCENT (g) | 4.4% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/36 (6%) 0/36 (0%) 0/33 (0%) 0/39 (0%) |
|FIRST INCIDENCE | 729 (T) --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.113N P=0.238N P=0.258N P=0.221N |
|POLY 3 | P=0.111N P=0.247N P=0.247N P=0.237N |
|POLY 1.5 | P=0.112N P=0.244N P=0.243N P=0.237N |
|POLY 6 | P=0.111N P=0.251N P=0.252N P=0.237N |
|LOGISTIC REGRESSION| P=0.113N (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.115N P=0.247N P=0.247N P=0.247N |
|ORDER RESTRICTED | P=0.029N* (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 5
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Brain |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 1/50 (2%) 0/50 (0%) |
|POLY-3 RATE (b) | 0/45.47 2/44.04 1/43.61 0/45.46 |
|POLY-3 PERCENT (g) | 0.0% 4.5% 2.3% 0.0% |
|TERMINAL (d) | 0/36 (0%) 0/36 (0%) 0/33 (0%) 0/39 (0%) |
|FIRST INCIDENCE | --- 649 696 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.461N P=0.221 P=0.480 (e) |
|POLY 3 | P=0.464N P=0.230 P=0.492 (e) |
|POLY 1.5 | P=0.463N P=0.232 P=0.495 (e) |
|POLY 6 | P=0.466N P=0.228 P=0.488 (e) |
|LOGISTIC REGRESSION| P=0.465N P=0.249 P=0.499 (e) |
|COCH-ARM / FISHERS | P=0.461N P=0.247 P=0.500 (e) |
|ORDER RESTRICTED | P=0.316 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Clitoral Gland |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/48 (2%) 1/49 (2%) 4/48 (8%) 1/49 (2%) |
|POLY-3 RATE (b) | 1/43.91 1/43.11 4/41.70 1/44.76 |
|POLY-3 PERCENT (g) | 2.3% 2.3% 9.6% 2.2% |
|TERMINAL (d) | 1/35 (3%) 1/36 (3%) 2/31 (7%) 1/39 (3%) |
|FIRST INCIDENCE | 729 (T) 729 (T) 696 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.550 P=0.756N P=0.149 P=0.738N |
|POLY 3 | P=0.540 P=0.757 P=0.163 P=0.756N |
|POLY 1.5 | P=0.538 P=0.759 P=0.169 P=0.756N |
|POLY 6 | P=0.543 P=0.753 P=0.155 P=0.757N |
|LOGISTIC REGRESSION| P=0.535 P=0.756N P=0.154 P=0.738N |
|COCH-ARM / FISHERS | P=0.532 P=0.747N P=0.181 P=0.747N |
|ORDER RESTRICTED | P=0.314 (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 6
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Eye |
| Developmental Malformation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/48 (2%) 0/50 (0%) 0/50 (0%) 4/50 (8%) |
|POLY-3 RATE (b) | 1/44.42 0/43.54 0/43.48 4/45.46 |
|POLY-3 PERCENT (g) | 2.3% 0.0% 0.0% 8.8% |
|TERMINAL (d) | 1/36 (3%) 0/36 (0%) 0/33 (0%) 4/39 (10%) |
|FIRST INCIDENCE | 729 (T) --- --- 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.035 * P=0.500N P=0.517N P=0.204 |
|POLY 3 | P=0.028 * P=0.504N P=0.504N P=0.186 |
|POLY 1.5 | P=0.028 * P=0.500N P=0.500N P=0.188 |
|POLY 6 | P=0.028 * P=0.508N P=0.509N P=0.184 |
|LOGISTIC REGRESSION| P=0.035 * (e) (e) P=0.204 |
|COCH-ARM / FISHERS | P=0.029 * P=0.490N P=0.490N P=0.194 |
|ORDER RESTRICTED | P=0.012 * (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Eye |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/48 (0%) 2/50 (4%) 0/50 (0%) 0/50 (0%) |
|POLY-3 RATE (b) | 0/44.42 2/44.15 0/43.48 0/45.46 |
|POLY-3 PERCENT (g) | 0.0% 4.5% 0.0% 0.0% |
|TERMINAL (d) | 0/36 (0%) 0/36 (0%) 0/33 (0%) 0/39 (0%) |
|FIRST INCIDENCE | --- 641 --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.404N P=0.222 (e) (e) |
|POLY 3 | P=0.411N P=0.236 (e) (e) |
|POLY 1.5 | P=0.407N P=0.238 (e) (e) |
|POLY 6 | P=0.414N P=0.234 (e) (e) |
|LOGISTIC REGRESSION| P=0.399N P=0.278 (e) (e) |
|COCH-ARM / FISHERS | P=0.398N P=0.258 (e) (e) |
|ORDER RESTRICTED | P=0.241N (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 7
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Eye |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/48 (0%) 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|POLY-3 RATE (b) | 0/44.42 0/43.54 0/43.48 2/45.46 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 4.4% |
|TERMINAL (d) | 0/36 (0%) 0/36 (0%) 0/33 (0%) 2/39 (5%) |
|FIRST INCIDENCE | --- --- --- 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.055 (e) (e) P=0.256 |
|POLY 3 | P=0.047 * (e) (e) P=0.242 |
|POLY 1.5 | P=0.047 * (e) (e) P=0.244 |
|POLY 6 | P=0.047 * (e) (e) P=0.241 |
|LOGISTIC REGRESSION| (e) (e) (e) P=0.256 |
|COCH-ARM / FISHERS | P=0.048 * (e) (e) P=0.258 |
|ORDER RESTRICTED | P=0.031 * (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Harderian Gland |
| Hyperplasia Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/50 (2%) 1/50 (2%) 2/50 (4%) 1/50 (2%) |
|POLY-3 RATE (b) | 1/45.47 1/43.54 2/43.73 1/45.46 |
|POLY-3 PERCENT (g) | 2.2% 2.3% 4.6% 2.2% |
|TERMINAL (d) | 1/36 (3%) 1/36 (3%) 1/33 (3%) 1/39 (3%) |
|FIRST INCIDENCE | 729 (T) 729 (T) 663 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.610 P=0.762 P=0.474 P=0.744N |
|POLY 3 | P=0.596 P=0.751 P=0.486 P=0.761 |
|POLY 1.5 | P=0.595 P=0.754 P=0.492 P=0.760N |
|POLY 6 | P=0.598 P=0.747 P=0.480 P=0.760 |
|LOGISTIC REGRESSION| P=0.593 P=0.762 P=0.489 P=0.744N |
|COCH-ARM / FISHERS | P=0.591 P=0.753N P=0.500 P=0.753N |
|ORDER RESTRICTED | P=0.576 (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 8
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Heart |
| Mineralization |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/50 (6%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|POLY-3 RATE (b) | 3/45.65 0/43.54 0/43.48 0/45.46 |
|POLY-3 PERCENT (g) | 6.6% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/36 (3%) 0/36 (0%) 0/33 (0%) 0/39 (0%) |
|FIRST INCIDENCE | 689 --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.050N P=0.132N P=0.144N P=0.118N |
|POLY 3 | P=0.043N* P=0.127N P=0.128N P=0.119N |
|POLY 1.5 | P=0.044N* P=0.125N P=0.124N P=0.119N |
|POLY 6 | P=0.043N* P=0.131N P=0.132N P=0.120N |
|LOGISTIC REGRESSION| P=0.048N* P=0.128N P=0.129N P=0.120N |
|COCH-ARM / FISHERS | P=0.047N* P=0.121N P=0.121N P=0.121N |
|ORDER RESTRICTED | P=0.008N** (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Intestine Large, Cecum |
| Edema |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 10/49 (20%) 8/48 (17%) 8/48 (17%) 4/49 (8%) |
|POLY-3 RATE (b) | 10/44.74 8/43.42 8/42.27 4/44.63 |
|POLY-3 PERCENT (g) | 22.4% 18.4% 18.9% 9.0% |
|TERMINAL (d) | 9/36 (25%) 6/36 (17%) 7/33 (21%) 4/39 (10%) |
|FIRST INCIDENCE | 689 641 669 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.049N* P=0.412N P=0.481N P=0.055N |
|POLY 3 | P=0.059N P=0.424N P=0.449N P=0.072N |
|POLY 1.5 | P=0.059N P=0.425N P=0.436N P=0.072N |
|POLY 6 | P=0.060N P=0.423N P=0.464N P=0.072N |
|LOGISTIC REGRESSION| P=0.059N P=0.436N P=0.478N P=0.070N |
|COCH-ARM / FISHERS | P=0.061N P=0.416N P=0.416N P=0.074N |
|ORDER RESTRICTED | P=0.066N (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 9
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Intestine Small, Duodenum: Epithelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/48 (2%) 1/48 (2%) 2/46 (4%) 0/46 (0%) |
|POLY-3 RATE (b) | 1/44.79 1/42.81 2/40.87 0/43.10 |
|POLY-3 PERCENT (g) | 2.2% 2.3% 4.9% 0.0% |
|TERMINAL (d) | 1/36 (3%) 1/36 (3%) 1/33 (3%) 0/39 (0%) |
|FIRST INCIDENCE | 729 (T) 729 (T) 707 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.355N P=0.762 P=0.464 P=0.484N |
|POLY 3 | P=0.375N P=0.750 P=0.468 P=0.508N |
|POLY 1.5 | P=0.377N P=0.753 P=0.474 P=0.508N |
|POLY 6 | P=0.371N P=0.748 P=0.464 P=0.506N |
|LOGISTIC REGRESSION| P=0.373N P=0.762 P=0.462 (e) |
|COCH-ARM / FISHERS | P=0.380N P=0.753N P=0.484 P=0.511N |
|ORDER RESTRICTED | P=0.261N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Intestine Small, Ileum: Epithelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/45 (0%) 1/46 (2%) 2/49 (4%) 0/49 (0%) |
|POLY-3 RATE (b) | 0/42.02 1/42.10 2/43.04 0/45.10 |
|POLY-3 PERCENT (g) | 0.0% 2.4% 4.7% 0.0% |
|TERMINAL (d) | 0/35 (0%) 1/36 (3%) 1/33 (3%) 0/39 (0%) |
|FIRST INCIDENCE | --- 729 (T) 604 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.599N P=0.506 P=0.228 (e) |
|POLY 3 | P=0.599N P=0.500 P=0.242 (e) |
|POLY 1.5 | P=0.597N P=0.502 P=0.247 (e) |
|POLY 6 | P=0.600N P=0.499 P=0.237 (e) |
|LOGISTIC REGRESSION| P=0.592N P=0.506 P=0.278 (e) |
|COCH-ARM / FISHERS | P=0.594N P=0.505 P=0.269 (e) |
|ORDER RESTRICTED | P=0.315N (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 10
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/49 (2%) 4/48 (8%) 3/48 (6%) 1/49 (2%) |
|POLY-3 RATE (b) | 1/44.91 4/42.54 3/41.70 1/45.10 |
|POLY-3 PERCENT (g) | 2.2% 9.4% 7.2% 2.2% |
|TERMINAL (d) | 1/36 (3%) 4/36 (11%) 3/33 (9%) 1/39 (3%) |
|FIRST INCIDENCE | 729 (T) 729 (T) 729 (T) 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.399N P=0.179 P=0.274 P=0.744N |
|POLY 3 | P=0.428N P=0.162 P=0.279 P=0.760N |
|POLY 1.5 | P=0.427N P=0.165 P=0.287 P=0.760N |
|POLY 6 | P=0.429N P=0.159 P=0.270 P=0.760N |
|LOGISTIC REGRESSION| P=0.399N P=0.179 P=0.274 P=0.744N |
|COCH-ARM / FISHERS | P=0.429N P=0.175 P=0.301 P=0.753N |
|ORDER RESTRICTED | P=0.305N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Kidney |
| Hyperplasia Lymphoid |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 8/50 (16%) 5/49 (10%) 5/50 (10%) 3/50 (6%) |
|POLY-3 RATE (b) | 8/45.77 5/43.17 5/43.48 3/45.46 |
|POLY-3 PERCENT (g) | 17.5% 11.6% 11.5% 6.6% |
|TERMINAL (d) | 7/36 (19%) 5/36 (14%) 5/33 (15%) 3/39 (8%) |
|FIRST INCIDENCE | 649 729 (T) 729 (T) 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.069N P=0.279N P=0.329N P=0.080N |
|POLY 3 | P=0.082N P=0.314N P=0.309N P=0.100N |
|POLY 1.5 | P=0.083N P=0.306N P=0.295N P=0.099N |
|POLY 6 | P=0.082N P=0.324N P=0.328N P=0.101N |
|LOGISTIC REGRESSION| P=0.082N P=0.320N P=0.331N P=0.099N |
|COCH-ARM / FISHERS | P=0.085N P=0.290N P=0.277N P=0.100N |
|ORDER RESTRICTED | P=0.077N (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 11
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Kidney |
| Infarct |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 2/49 (4%) 3/50 (6%) 5/50 (10%) |
|POLY-3 RATE (b) | 2/45.47 2/43.17 3/43.48 5/45.69 |
|POLY-3 PERCENT (g) | 4.4% 4.6% 6.9% 10.9% |
|TERMINAL (d) | 2/36 (6%) 2/36 (6%) 3/33 (9%) 4/39 (10%) |
|FIRST INCIDENCE | 729 (T) 729 (T) 729 (T) 669 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.138 P=0.695 P=0.460 P=0.246 |
|POLY 3 | P=0.119 P=0.675 P=0.480 P=0.218 |
|POLY 1.5 | P=0.119 P=0.678 P=0.488 P=0.218 |
|POLY 6 | P=0.120 P=0.671 P=0.469 P=0.219 |
|LOGISTIC REGRESSION| P=0.120 P=0.695 P=0.460 P=0.215 |
|COCH-ARM / FISHERS | P=0.116 P=0.684 P=0.500 P=0.218 |
|ORDER RESTRICTED | P=0.161 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Kidney |
| Metaplasia Osseous |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 0/49 (0%) 0/50 (0%) 1/50 (2%) |
|POLY-3 RATE (b) | 2/45.47 0/43.17 0/43.48 1/45.46 |
|POLY-3 PERCENT (g) | 4.4% 0.0% 0.0% 2.2% |
|TERMINAL (d) | 2/36 (6%) 0/36 (0%) 0/33 (0%) 1/39 (3%) |
|FIRST INCIDENCE | 729 (T) --- --- 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.443N P=0.238N P=0.258N P=0.472N |
|POLY 3 | P=0.457N P=0.249N P=0.247N P=0.500N |
|POLY 1.5 | P=0.457N P=0.247N P=0.243N P=0.500N |
|POLY 6 | P=0.457N P=0.251N P=0.252N P=0.500N |
|LOGISTIC REGRESSION| P=0.443N (e) (e) P=0.472N |
|COCH-ARM / FISHERS | P=0.459N P=0.253N P=0.247N P=0.500N |
|ORDER RESTRICTED | P=0.134N (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 12
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Kidney |
| Nephropathy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 16/50 (32%) 14/49 (29%) 7/50 (14%) 8/50 (16%) |
|POLY-3 RATE (b) | 16/46.32 14/44.20 7/44.01 8/45.63 |
|POLY-3 PERCENT (g) | 34.6% 31.7% 15.9% 17.5% |
|TERMINAL (d) | 11/36 (31%) 11/36 (31%) 5/33 (15%) 7/39 (18%) |
|FIRST INCIDENCE | 649 547 658 686 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.019N* P=0.449N P=0.057N P=0.043N* |
|POLY 3 | P=0.019N* P=0.473N P=0.034N* P=0.050N |
|POLY 1.5 | P=0.019N* P=0.464N P=0.031N* P=0.049N* |
|POLY 6 | P=0.020N* P=0.489N P=0.040N* P=0.053N |
|LOGISTIC REGRESSION| P=0.019N* P=0.475N P=0.036N* P=0.049N* |
|COCH-ARM / FISHERS | P=0.020N* P=0.440N P=0.028N* P=0.050N |
|ORDER RESTRICTED | P=0.029N* (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Accumulation, Hyaline Droplet |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 6/49 (12%) 4/50 (8%) 1/50 (2%) |
|POLY-3 RATE (b) | 2/45.49 6/44.72 4/43.77 1/45.69 |
|POLY-3 PERCENT (g) | 4.4% 13.4% 9.1% 2.2% |
|TERMINAL (d) | 1/36 (3%) 1/36 (3%) 2/33 (6%) 0/39 (0%) |
|FIRST INCIDENCE | 724 581 669 669 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.231N P=0.131 P=0.292 P=0.485N |
|POLY 3 | P=0.228N P=0.127 P=0.319 P=0.499N |
|POLY 1.5 | P=0.229N P=0.125 P=0.326 P=0.499N |
|POLY 6 | P=0.228N P=0.131 P=0.311 P=0.498N |
|LOGISTIC REGRESSION| P=0.232N P=0.136 P=0.311 P=0.500N |
|COCH-ARM / FISHERS | P=0.231N P=0.128 P=0.339 P=0.500N |
|ORDER RESTRICTED | P=0.159N (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 13
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 0/49 (0%) 2/50 (4%) 1/50 (2%) |
|POLY-3 RATE (b) | 2/46.01 0/43.17 2/44.21 1/45.63 |
|POLY-3 PERCENT (g) | 4.4% 0.0% 4.5% 2.2% |
|TERMINAL (d) | 0/36 (0%) 0/36 (0%) 0/33 (0%) 0/39 (0%) |
|FIRST INCIDENCE | 606 --- 583 686 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.525N P=0.259N P=0.663 P=0.503N |
|POLY 3 | P=0.522N P=0.252N P=0.680 P=0.503N |
|POLY 1.5 | P=0.523N P=0.248N P=0.685 P=0.501N |
|POLY 6 | P=0.520N P=0.256N P=0.673 P=0.505N |
|LOGISTIC REGRESSION| P=0.543N P=0.224N P=0.666N P=0.506N |
|COCH-ARM / FISHERS | P=0.528N P=0.253N P=0.691N P=0.500N |
|ORDER RESTRICTED | P=0.418N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Pigmentation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 0/49 (0%) 0/50 (0%) 1/50 (2%) |
|POLY-3 RATE (b) | 2/45.92 0/43.17 0/43.48 1/45.76 |
|POLY-3 PERCENT (g) | 4.4% 0.0% 0.0% 2.2% |
|TERMINAL (d) | 0/36 (0%) 0/36 (0%) 0/33 (0%) 0/39 (0%) |
|FIRST INCIDENCE | 606 --- --- 647 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.456N P=0.251N P=0.260N P=0.497N |
|POLY 3 | P=0.456N P=0.251N P=0.250N P=0.501N |
|POLY 1.5 | P=0.457N P=0.248N P=0.244N P=0.500N |
|POLY 6 | P=0.455N P=0.255N P=0.256N P=0.502N |
|LOGISTIC REGRESSION| P=0.466N P=0.229N P=0.226N P=0.508N |
|COCH-ARM / FISHERS | P=0.459N P=0.253N P=0.247N P=0.500N |
|ORDER RESTRICTED | P=0.135N (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 14
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Liver |
| Basophilic Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/50 (6%) 0/50 (0%) 5/50 (10%) 2/50 (4%) |
|POLY-3 RATE (b) | 3/46.28 0/43.54 5/43.73 2/45.46 |
|POLY-3 PERCENT (g) | 6.5% 0.0% 11.4% 4.4% |
|TERMINAL (d) | 2/36 (6%) 0/36 (0%) 4/33 (12%) 2/39 (5%) |
|FIRST INCIDENCE | 423 --- 663 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.573 P=0.124N P=0.320 P=0.469N |
|POLY 3 | P=0.552 P=0.130N P=0.326 P=0.508N |
|POLY 1.5 | P=0.551 P=0.126N P=0.337 P=0.505N |
|POLY 6 | P=0.555 P=0.134N P=0.313 P=0.510N |
|LOGISTIC REGRESSION| P=0.544 P=0.093N P=0.366 P=0.507N |
|COCH-ARM / FISHERS | P=0.544 P=0.121N P=0.357 P=0.500N |
|ORDER RESTRICTED | P=0.269 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Liver |
| Clear Cell Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 2/50 (4%) 3/50 (6%) |
|POLY-3 RATE (b) | 2/45.47 1/43.86 2/43.73 3/46.19 |
|POLY-3 PERCENT (g) | 4.4% 2.3% 4.6% 6.5% |
|TERMINAL (d) | 2/36 (6%) 0/36 (0%) 1/33 (3%) 2/39 (5%) |
|FIRST INCIDENCE | 729 (T) 641 664 472 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.339 P=0.508N P=0.661 P=0.531 |
|POLY 3 | P=0.325 P=0.513N P=0.680 P=0.507 |
|POLY 1.5 | P=0.322 P=0.509N P=0.685 P=0.505 |
|POLY 6 | P=0.328 P=0.516N P=0.673 P=0.509 |
|LOGISTIC REGRESSION| P=0.307 P=0.506N P=0.679 P=0.496 |
|COCH-ARM / FISHERS | P=0.313 P=0.500N P=0.691N P=0.500 |
|ORDER RESTRICTED | P=0.369 (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 15
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Liver |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 0/50 (0%) 0/50 (0%) |
|POLY-3 RATE (b) | 2/45.47 0/43.54 0/43.48 0/45.46 |
|POLY-3 PERCENT (g) | 4.4% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/36 (6%) 0/36 (0%) 0/33 (0%) 0/39 (0%) |
|FIRST INCIDENCE | 729 (T) --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.113N P=0.238N P=0.258N P=0.221N |
|POLY 3 | P=0.111N P=0.247N P=0.247N P=0.237N |
|POLY 1.5 | P=0.112N P=0.244N P=0.243N P=0.237N |
|POLY 6 | P=0.111N P=0.251N P=0.252N P=0.237N |
|LOGISTIC REGRESSION| P=0.113N (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.115N P=0.247N P=0.247N P=0.247N |
|ORDER RESTRICTED | P=0.029N* (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Liver |
| Eosinophilic Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 7/50 (14%) 4/50 (8%) 8/50 (16%) 4/50 (8%) |
|POLY-3 RATE (b) | 7/45.47 4/44.17 8/43.84 4/46.19 |
|POLY-3 PERCENT (g) | 15.4% 9.1% 18.3% 8.7% |
|TERMINAL (d) | 7/36 (19%) 3/36 (8%) 6/33 (18%) 3/39 (8%) |
|FIRST INCIDENCE | 729 (T) 521 664 472 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.277N P=0.261N P=0.424 P=0.220N |
|POLY 3 | P=0.293N P=0.277N P=0.469 P=0.252N |
|POLY 1.5 | P=0.299N P=0.273N P=0.481 P=0.255N |
|POLY 6 | P=0.287N P=0.282N P=0.456 P=0.249N |
|LOGISTIC REGRESSION| P=0.309N P=0.282N P=0.428 P=0.261N |
|COCH-ARM / FISHERS | P=0.313N P=0.262N P=0.500 P=0.262N |
|ORDER RESTRICTED | P=0.261N (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 16
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Liver |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 4/50 (8%) 2/50 (4%) 1/50 (2%) 1/50 (2%) |
|POLY-3 RATE (b) | 4/45.70 2/43.54 1/43.48 1/45.46 |
|POLY-3 PERCENT (g) | 8.8% 4.6% 2.3% 2.2% |
|TERMINAL (d) | 3/36 (8%) 2/36 (6%) 1/33 (3%) 1/39 (3%) |
|FIRST INCIDENCE | 669 729 (T) 729 (T) 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.103N P=0.345N P=0.211N P=0.163N |
|POLY 3 | P=0.110N P=0.360N P=0.194N P=0.180N |
|POLY 1.5 | P=0.110N P=0.352N P=0.188N P=0.179N |
|POLY 6 | P=0.109N P=0.369N P=0.203N P=0.181N |
|LOGISTIC REGRESSION| P=0.111N P=0.363N P=0.197N P=0.179N |
|COCH-ARM / FISHERS | P=0.111N P=0.339N P=0.181N P=0.181N |
|ORDER RESTRICTED | P=0.096N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Liver |
| Hyperplasia Lymphoid |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 5/50 (10%) 6/50 (12%) 1/50 (2%) |
|POLY-3 RATE (b) | 2/45.47 5/43.54 6/43.48 1/45.46 |
|POLY-3 PERCENT (g) | 4.4% 11.5% 13.8% 2.2% |
|TERMINAL (d) | 2/36 (6%) 5/36 (14%) 6/33 (18%) 1/39 (3%) |
|FIRST INCIDENCE | 729 (T) 729 (T) 729 (T) 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.284N P=0.215 P=0.105 P=0.472N |
|POLY 3 | P=0.314N P=0.198 P=0.118 P=0.500N |
|POLY 1.5 | P=0.315N P=0.204 P=0.124 P=0.500N |
|POLY 6 | P=0.313N P=0.192 P=0.111 P=0.500N |
|LOGISTIC REGRESSION| P=0.284N P=0.215 P=0.105 P=0.472N |
|COCH-ARM / FISHERS | P=0.320N P=0.218 P=0.134 P=0.500N |
|ORDER RESTRICTED | P=0.131N (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 17
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Liver |
| Infarct |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/50 (0%) 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|POLY-3 RATE (b) | 0/45.47 0/43.54 0/43.48 2/45.46 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 4.4% |
|TERMINAL (d) | 0/36 (0%) 0/36 (0%) 0/33 (0%) 2/39 (5%) |
|FIRST INCIDENCE | --- --- --- 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.055 (e) (e) P=0.256 |
|POLY 3 | P=0.046 * (e) (e) P=0.237 |
|POLY 1.5 | P=0.046 * (e) (e) P=0.237 |
|POLY 6 | P=0.046 * (e) (e) P=0.237 |
|LOGISTIC REGRESSION| (e) (e) (e) P=0.256 |
|COCH-ARM / FISHERS | P=0.046 * (e) (e) P=0.247 |
|ORDER RESTRICTED | P=0.029 * (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Liver |
| Infiltration Cellular Mixed Cell |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 6/50 (12%) 6/50 (12%) 7/50 (14%) 5/50 (10%) |
|POLY-3 RATE (b) | 6/45.47 6/44.75 7/44.32 5/45.60 |
|POLY-3 PERCENT (g) | 13.2% 13.4% 15.8% 11.0% |
|TERMINAL (d) | 6/36 (17%) 4/36 (11%) 5/33 (15%) 4/39 (10%) |
|FIRST INCIDENCE | 729 (T) 521 539 693 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.400N P=0.617 P=0.435 P=0.449N |
|POLY 3 | P=0.437N P=0.610 P=0.480 P=0.498N |
|POLY 1.5 | P=0.437N P=0.611 P=0.488 P=0.498N |
|POLY 6 | P=0.435N P=0.608 P=0.471 P=0.497N |
|LOGISTIC REGRESSION| P=0.438N P=0.614 P=0.471 P=0.498N |
|COCH-ARM / FISHERS | P=0.442N P=0.620N P=0.500 P=0.500N |
|ORDER RESTRICTED | P=0.517N (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 18
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Liver |
| Mixed Cell Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/50 (6%) 3/50 (6%) 3/50 (6%) 2/50 (4%) |
|POLY-3 RATE (b) | 3/45.53 3/43.54 3/44.08 2/45.46 |
|POLY-3 PERCENT (g) | 6.6% 6.9% 6.8% 4.4% |
|TERMINAL (d) | 2/36 (6%) 3/36 (8%) 2/33 (6%) 2/39 (5%) |
|FIRST INCIDENCE | 715 729 (T) 539 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.372N P=0.654 P=0.616 P=0.473N |
|POLY 3 | P=0.393N P=0.642 P=0.647 P=0.501N |
|POLY 1.5 | P=0.393N P=0.648 P=0.653 P=0.500N |
|POLY 6 | P=0.392N P=0.634 P=0.639 P=0.502N |
|LOGISTIC REGRESSION| P=0.393N P=0.628 P=0.661 P=0.498N |
|COCH-ARM / FISHERS | P=0.397N P=0.661N P=0.661N P=0.500N |
|ORDER RESTRICTED | P=0.503N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Liver |
| Necrosis Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/50 (6%) 5/50 (10%) 2/50 (4%) 4/50 (8%) |
|POLY-3 RATE (b) | 3/45.50 5/45.39 2/43.71 4/45.81 |
|POLY-3 PERCENT (g) | 6.6% 11.0% 4.6% 8.7% |
|TERMINAL (d) | 2/36 (6%) 1/36 (3%) 1/33 (3%) 3/39 (8%) |
|FIRST INCIDENCE | 723 318 669 631 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.562 P=0.342 P=0.547N P=0.534 |
|POLY 3 | P=0.538 P=0.355 P=0.518N P=0.504 |
|POLY 1.5 | P=0.538 P=0.355 P=0.511N P=0.503 |
|POLY 6 | P=0.539 P=0.356 P=0.527N P=0.506 |
|LOGISTIC REGRESSION| P=0.527 P=0.406 P=0.526N P=0.500 |
|COCH-ARM / FISHERS | P=0.537 P=0.357 P=0.500N P=0.500 |
|ORDER RESTRICTED | P=0.550 (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 19
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Liver |
| Tension Lipidosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|POLY-3 RATE (b) | 2/46.01 0/43.54 0/43.48 2/45.46 |
|POLY-3 PERCENT (g) | 4.4% 0.0% 0.0% 4.4% |
|TERMINAL (d) | 1/36 (3%) 0/36 (0%) 0/33 (0%) 2/39 (5%) |
|FIRST INCIDENCE | 563 --- --- 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.514 P=0.247N P=0.257N P=0.676N |
|POLY 3 | P=0.506 P=0.250N P=0.250N P=0.689 |
|POLY 1.5 | P=0.505 P=0.245N P=0.245N P=0.692 |
|POLY 6 | P=0.508 P=0.255N P=0.257N P=0.687 |
|LOGISTIC REGRESSION| P=0.499 P=0.214N P=0.219N P=0.694 |
|COCH-ARM / FISHERS | P=0.500 P=0.247N P=0.247N P=0.691N |
|ORDER RESTRICTED | P=0.273 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Liver: Centrilobular |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 6/50 (12%) 1/50 (2%) 2/50 (4%) 3/50 (6%) |
|POLY-3 RATE (b) | 6/47.38 1/43.97 2/44.16 3/46.50 |
|POLY-3 PERCENT (g) | 12.7% 2.3% 4.5% 6.5% |
|TERMINAL (d) | 0/36 (0%) 0/36 (0%) 0/33 (0%) 0/39 (0%) |
|FIRST INCIDENCE | 563 604 604 522 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.281N P=0.078N P=0.169N P=0.260N |
|POLY 3 | P=0.263N P=0.069N P=0.157N P=0.252N |
|POLY 1.5 | P=0.265N P=0.064N P=0.147N P=0.247N |
|POLY 6 | P=0.261N P=0.076N P=0.171N P=0.259N |
|LOGISTIC REGRESSION| P=0.294N P=0.038N* P=0.101N P=0.246N |
|COCH-ARM / FISHERS | P=0.273N P=0.056N P=0.134N P=0.243N |
|ORDER RESTRICTED | P=0.077N (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 20
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Liver: Hepatocyte |
| Depletion Glycogen |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/50 (6%) 2/50 (4%) 1/50 (2%) 0/50 (0%) |
|POLY-3 RATE (b) | 3/45.47 2/43.54 1/43.48 0/45.46 |
|POLY-3 PERCENT (g) | 6.6% 4.6% 2.3% 0.0% |
|TERMINAL (d) | 3/36 (8%) 2/36 (6%) 1/33 (3%) 0/39 (0%) |
|FIRST INCIDENCE | 729 (T) 729 (T) 729 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.057N P=0.500N P=0.336N P=0.107N |
|POLY 3 | P=0.061N P=0.520N P=0.321N P=0.119N |
|POLY 1.5 | P=0.061N P=0.514N P=0.315N P=0.119N |
|POLY 6 | P=0.060N P=0.527N P=0.330N P=0.119N |
|LOGISTIC REGRESSION| P=0.057N P=0.500N P=0.336N (e) |
|COCH-ARM / FISHERS | P=0.062N P=0.500N P=0.309N P=0.121N |
|ORDER RESTRICTED | P=0.057N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Liver: Hepatocyte |
| Karyomegaly |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 4/50 (8%) 0/50 (0%) 0/50 (0%) |
|POLY-3 RATE (b) | 2/45.47 4/43.54 0/43.48 0/45.46 |
|POLY-3 PERCENT (g) | 4.4% 9.2% 0.0% 0.0% |
|TERMINAL (d) | 2/36 (6%) 4/36 (11%) 0/33 (0%) 0/39 (0%) |
|FIRST INCIDENCE | 729 (T) 729 (T) --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.057N P=0.336 P=0.258N P=0.221N |
|POLY 3 | P=0.061N P=0.317 P=0.247N P=0.237N |
|POLY 1.5 | P=0.061N P=0.324 P=0.243N P=0.237N |
|POLY 6 | P=0.062N P=0.309 P=0.252N P=0.237N |
|LOGISTIC REGRESSION| P=0.057N P=0.336 (e) (e) |
|COCH-ARM / FISHERS | P=0.062N P=0.339 P=0.247N P=0.247N |
|ORDER RESTRICTED | P=0.049N* (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 21
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Liver: Hepatocyte |
| Vacuolization Cytoplasmic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 6/50 (12%) 3/50 (6%) 6/50 (12%) 3/50 (6%) |
|POLY-3 RATE (b) | 6/46.43 3/44.49 6/45.85 3/45.69 |
|POLY-3 PERCENT (g) | 12.9% 6.7% 13.1% 6.6% |
|TERMINAL (d) | 2/36 (6%) 1/36 (3%) 1/33 (3%) 2/39 (5%) |
|FIRST INCIDENCE | 581 521 455 669 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.274N P=0.276N P=0.567 P=0.239N |
|POLY 3 | P=0.278N P=0.263N P=0.612 P=0.250N |
|POLY 1.5 | P=0.277N P=0.257N P=0.616 P=0.246N |
|POLY 6 | P=0.280N P=0.273N P=0.603 P=0.255N |
|LOGISTIC REGRESSION| P=0.296N P=0.216N P=0.560N P=0.243N |
|COCH-ARM / FISHERS | P=0.279N P=0.243N P=0.620N P=0.243N |
|ORDER RESTRICTED | P=0.242N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Liver: Kupffer Cell |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 0/50 (0%) 0/50 (0%) |
|POLY-3 RATE (b) | 2/45.97 1/43.69 0/43.48 0/45.46 |
|POLY-3 PERCENT (g) | 4.4% 2.3% 0.0% 0.0% |
|TERMINAL (d) | 1/36 (3%) 0/36 (0%) 0/33 (0%) 0/39 (0%) |
|FIRST INCIDENCE | 581 689 --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.104N P=0.517N P=0.254N P=0.233N |
|POLY 3 | P=0.101N P=0.518N P=0.250N P=0.240N |
|POLY 1.5 | P=0.100N P=0.512N P=0.245N P=0.238N |
|POLY 6 | P=0.101N P=0.524N P=0.256N P=0.241N |
|LOGISTIC REGRESSION| P=0.100N P=0.482N P=0.222N P=0.242N |
|COCH-ARM / FISHERS | P=0.101N P=0.500N P=0.247N P=0.247N |
|ORDER RESTRICTED | P=0.076N (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 22
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Liver: Kupffer Cell |
| Pigmentation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 7/50 (14%) 0/50 (0%) 2/50 (4%) 1/50 (2%) |
|POLY-3 RATE (b) | 7/45.91 0/43.54 2/43.73 1/45.46 |
|POLY-3 PERCENT (g) | 15.3% 0.0% 4.6% 2.2% |
|TERMINAL (d) | 4/36 (11%) 0/36 (0%) 1/33 (3%) 1/39 (3%) |
|FIRST INCIDENCE | 669 --- 664 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.032N* P=0.013N* P=0.117N P=0.031N* |
|POLY 3 | P=0.026N* P=0.009N** P=0.091N P=0.031N* |
|POLY 1.5 | P=0.026N* P=0.009N** P=0.086N P=0.031N* |
|POLY 6 | P=0.025N* P=0.010N* P=0.097N P=0.032N* |
|LOGISTIC REGRESSION| P=0.031N* P=0.011N* P=0.089N P=0.032N* |
|COCH-ARM / FISHERS | P=0.031N* P=0.006N** P=0.080N P=0.030N* |
|ORDER RESTRICTED | P=0.003N** (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Lung |
| Foreign Body |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 0/50 (0%) 2/50 (4%) |
|POLY-3 RATE (b) | 1/45.91 0/43.54 0/43.48 2/45.46 |
|POLY-3 PERCENT (g) | 2.2% 0.0% 0.0% 4.4% |
|TERMINAL (d) | 0/36 (0%) 0/36 (0%) 0/33 (0%) 2/39 (5%) |
|FIRST INCIDENCE | 604 --- --- 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.260 P=0.509N P=0.509N P=0.516 |
|POLY 3 | P=0.249 P=0.511N P=0.511N P=0.497 |
|POLY 1.5 | P=0.248 P=0.507N P=0.506N P=0.499 |
|POLY 6 | P=0.250 P=0.515N P=0.517N P=0.494 |
|LOGISTIC REGRESSION| P=0.244 P=0.461N P=0.473N P=0.499 |
|COCH-ARM / FISHERS | P=0.246 P=0.500N P=0.500N P=0.500 |
|ORDER RESTRICTED | P=0.131 (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 23
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Lung |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 6/50 (12%) 7/50 (14%) 6/50 (12%) 7/50 (14%) |
|POLY-3 RATE (b) | 6/46.03 7/44.18 6/44.12 7/45.94 |
|POLY-3 PERCENT (g) | 13.0% 15.8% 13.6% 15.2% |
|TERMINAL (d) | 3/36 (8%) 5/36 (14%) 3/33 (9%) 6/39 (15%) |
|FIRST INCIDENCE | 604 640 659 587 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.515 P=0.482 P=0.555 P=0.542 |
|POLY 3 | P=0.476 P=0.468 P=0.591 P=0.498 |
|POLY 1.5 | P=0.477 P=0.478 P=0.602 P=0.500 |
|POLY 6 | P=0.475 P=0.458 P=0.577 P=0.496 |
|LOGISTIC REGRESSION| P=0.477 P=0.482 P=0.608 P=0.500 |
|COCH-ARM / FISHERS | P=0.472 P=0.500 P=0.620N P=0.500 |
|ORDER RESTRICTED | P=0.595 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Lung |
| Hyperplasia Lymphoid |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/50 (2%) 0/50 (0%) 4/50 (8%) 1/50 (2%) |
|POLY-3 RATE (b) | 1/45.47 0/43.54 4/43.73 1/46.07 |
|POLY-3 PERCENT (g) | 2.2% 0.0% 9.2% 2.2% |
|TERMINAL (d) | 1/36 (3%) 0/36 (0%) 3/33 (9%) 0/39 (0%) |
|FIRST INCIDENCE | 729 (T) --- 663 535 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.465 P=0.500N P=0.158 P=0.754N |
|POLY 3 | P=0.465 P=0.509N P=0.167 P=0.758N |
|POLY 1.5 | P=0.458 P=0.506N P=0.172 P=0.758N |
|POLY 6 | P=0.472 P=0.512N P=0.161 P=0.757N |
|LOGISTIC REGRESSION| P=0.442 (e) P=0.162 P=0.753 |
|COCH-ARM / FISHERS | P=0.444 P=0.500N P=0.181 P=0.753N |
|ORDER RESTRICTED | P=0.177 (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 24
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Lung |
| Infiltration Cellular Histiocyte |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 1/50 (2%) 5/50 (10%) 0/50 (0%) |
|POLY-3 RATE (b) | 2/45.53 1/43.54 5/43.67 0/45.46 |
|POLY-3 PERCENT (g) | 4.4% 2.3% 11.5% 0.0% |
|TERMINAL (d) | 1/36 (3%) 1/36 (3%) 3/33 (9%) 0/39 (0%) |
|FIRST INCIDENCE | 715 729 (T) 696 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.302N P=0.512N P=0.178 P=0.234N |
|POLY 3 | P=0.302N P=0.516N P=0.199 P=0.237N |
|POLY 1.5 | P=0.304N P=0.511N P=0.206 P=0.237N |
|POLY 6 | P=0.299N P=0.522N P=0.191 P=0.238N |
|LOGISTIC REGRESSION| P=0.310N P=0.525N P=0.187 P=0.237N |
|COCH-ARM / FISHERS | P=0.313N P=0.500N P=0.218 P=0.247N |
|ORDER RESTRICTED | P=0.119N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Lung |
| Thrombosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 1/50 (2%) 0/50 (0%) |
|POLY-3 RATE (b) | 1/46.01 2/44.07 1/43.91 0/45.46 |
|POLY-3 PERCENT (g) | 2.2% 4.5% 2.3% 0.0% |
|TERMINAL (d) | 0/36 (0%) 0/36 (0%) 0/33 (0%) 0/39 (0%) |
|FIRST INCIDENCE | 563 641 604 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.252N P=0.476 P=0.748 P=0.508N |
|POLY 3 | P=0.252N P=0.485 P=0.750 P=0.502N |
|POLY 1.5 | P=0.250N P=0.489 P=0.754 P=0.501N |
|POLY 6 | P=0.255N P=0.481 P=0.745 P=0.504N |
|LOGISTIC REGRESSION| P=0.259N P=0.549 P=0.732N P=0.539N |
|COCH-ARM / FISHERS | P=0.247N P=0.500 P=0.753N P=0.500N |
|ORDER RESTRICTED | P=0.218N (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 25
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Lung: Alveolar Epithelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 1/50 (2%) 2/50 (4%) |
|POLY-3 RATE (b) | 0/45.47 2/43.54 1/43.48 2/45.46 |
|POLY-3 PERCENT (g) | 0.0% 4.6% 2.3% 4.4% |
|TERMINAL (d) | 0/36 (0%) 2/36 (6%) 1/33 (3%) 2/39 (5%) |
|FIRST INCIDENCE | --- 729 (T) 729 (T) 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.270 P=0.238 P=0.483 P=0.256 |
|POLY 3 | P=0.246 P=0.227 P=0.491 P=0.237 |
|POLY 1.5 | P=0.246 P=0.231 P=0.495 P=0.237 |
|POLY 6 | P=0.245 P=0.224 P=0.486 P=0.237 |
|LOGISTIC REGRESSION| (e) P=0.238 P=0.483 P=0.256 |
|COCH-ARM / FISHERS | P=0.245 P=0.247 P=0.500 P=0.247 |
|ORDER RESTRICTED | P=0.155 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Lung: Alveolar Epithelium |
| Metaplasia Bronchiolar |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/50 (0%) 2/50 (4%) 0/50 (0%) 0/50 (0%) |
|POLY-3 RATE (b) | 0/45.47 2/44.03 0/43.48 0/45.46 |
|POLY-3 PERCENT (g) | 0.0% 4.5% 0.0% 0.0% |
|TERMINAL (d) | 0/36 (0%) 1/36 (3%) 0/33 (0%) 0/39 (0%) |
|FIRST INCIDENCE | --- 581 --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.401N P=0.235 (e) (e) |
|POLY 3 | P=0.412N P=0.230 (e) (e) |
|POLY 1.5 | P=0.409N P=0.232 (e) (e) |
|POLY 6 | P=0.415N P=0.228 (e) (e) |
|LOGISTIC REGRESSION| P=0.411N P=0.251 (e) (e) |
|COCH-ARM / FISHERS | P=0.405N P=0.247 (e) (e) |
|ORDER RESTRICTED | P=0.241N (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 26
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 1/50 (2%) 1/47 (2%) |
|POLY-3 RATE (b) | 2/46.86 0/43.54 1/43.73 1/43.91 |
|POLY-3 PERCENT (g) | 4.3% 0.0% 2.3% 2.3% |
|TERMINAL (d) | 0/36 (0%) 0/36 (0%) 0/33 (0%) 0/38 (0%) |
|FIRST INCIDENCE | 350 --- 664 424 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.495N P=0.249N P=0.519N P=0.498N |
|POLY 3 | P=0.509N P=0.254N P=0.524N P=0.523N |
|POLY 1.5 | P=0.512N P=0.249N P=0.515N P=0.522N |
|POLY 6 | P=0.505N P=0.260N P=0.534N P=0.522N |
|LOGISTIC REGRESSION| P=0.621N P=0.106N P=0.420N P=0.642N |
|COCH-ARM / FISHERS | P=0.519N P=0.247N P=0.500N P=0.523N |
|ORDER RESTRICTED | P=0.297N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/50 (2%) 2/50 (4%) 0/50 (0%) 1/47 (2%) |
|POLY-3 RATE (b) | 1/46.01 2/43.54 0/43.48 1/43.11 |
|POLY-3 PERCENT (g) | 2.2% 4.6% 0.0% 2.3% |
|TERMINAL (d) | 0/36 (0%) 2/36 (6%) 0/33 (0%) 1/38 (3%) |
|FIRST INCIDENCE | 563 729 (T) --- 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.492N P=0.493 P=0.513N P=0.759N |
|POLY 3 | P=0.525N P=0.481 P=0.511N P=0.746 |
|POLY 1.5 | P=0.522N P=0.487 P=0.507N P=0.746 |
|POLY 6 | P=0.527N P=0.473 P=0.517N P=0.746 |
|LOGISTIC REGRESSION| P=0.520N P=0.512 P=0.464N P=0.740 |
|COCH-ARM / FISHERS | P=0.519N P=0.500 P=0.500N P=0.737 |
|ORDER RESTRICTED | P=0.387N (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 27
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/50 (0%) 3/50 (6%) 2/50 (4%) 3/47 (6%) |
|POLY-3 RATE (b) | 0/45.47 3/44.11 2/43.61 3/43.74 |
|POLY-3 PERCENT (g) | 0.0% 6.8% 4.6% 6.9% |
|TERMINAL (d) | 0/36 (0%) 2/36 (6%) 1/33 (3%) 2/38 (5%) |
|FIRST INCIDENCE | --- 547 696 522 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.178 P=0.120 P=0.219 P=0.129 |
|POLY 3 | P=0.153 P=0.113 P=0.228 P=0.112 |
|POLY 1.5 | P=0.150 P=0.115 P=0.232 P=0.110 |
|POLY 6 | P=0.156 P=0.111 P=0.223 P=0.114 |
|LOGISTIC REGRESSION| P=0.140 P=0.127 P=0.227 P=0.103 |
|COCH-ARM / FISHERS | P=0.146 P=0.121 P=0.247 P=0.110 |
|ORDER RESTRICTED | P=0.089 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Hyperplasia Lymphoid |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 8/50 (16%) 9/50 (18%) 6/50 (12%) 9/47 (19%) |
|POLY-3 RATE (b) | 8/45.90 9/44.91 6/43.91 9/43.44 |
|POLY-3 PERCENT (g) | 17.4% 20.0% 13.7% 20.7% |
|TERMINAL (d) | 7/36 (19%) 6/36 (17%) 5/33 (15%) 7/38 (18%) |
|FIRST INCIDENCE | 606 521 604 669 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.533 P=0.490 P=0.450N P=0.540 |
|POLY 3 | P=0.448 P=0.480 P=0.421N P=0.450 |
|POLY 1.5 | P=0.447 P=0.485 P=0.407N P=0.448 |
|POLY 6 | P=0.452 P=0.474 P=0.438N P=0.456 |
|LOGISTIC REGRESSION| P=0.452 P=0.491 P=0.419N P=0.452 |
|COCH-ARM / FISHERS | P=0.442 P=0.500 P=0.387N P=0.444 |
|ORDER RESTRICTED | P=0.515 (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 28
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Pigmentation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 22/50 (44%) 27/50 (54%) 25/50 (50%) 20/47 (43%) |
|POLY-3 RATE (b) | 22/47.62 27/44.63 25/44.21 20/43.46 |
|POLY-3 PERCENT (g) | 46.2% 60.5% 56.6% 46.0% |
|TERMINAL (d) | 17/36 (47%) 23/36 (64%) 21/33 (64%) 19/38 (50%) |
|FIRST INCIDENCE | 350 604 658 631 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.207N P=0.203 P=0.218 P=0.347N |
|POLY 3 | P=0.414N P=0.118 P=0.214 P=0.577N |
|POLY 1.5 | P=0.396N P=0.144 P=0.260 P=0.557N |
|POLY 6 | P=0.431N P=0.096 P=0.169 P=0.575 |
|LOGISTIC REGRESSION| P=0.338N P=0.165 P=0.281 P=0.517N |
|COCH-ARM / FISHERS | P=0.375N P=0.212 P=0.344 P=0.525N |
|ORDER RESTRICTED | P=0.334 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Lymph Node, Mesenteric |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/49 (2%) 0/48 (0%) 0/46 (0%) 2/50 (4%) |
|POLY-3 RATE (b) | 1/45.36 0/42.17 0/40.29 2/46.99 |
|POLY-3 PERCENT (g) | 2.2% 0.0% 0.0% 4.3% |
|TERMINAL (d) | 0/35 (0%) 0/35 (0%) 0/32 (0%) 0/39 (0%) |
|FIRST INCIDENCE | 350 --- --- 424 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.254 P=0.508N P=0.504N P=0.507 |
|POLY 3 | P=0.260 P=0.515N P=0.524N P=0.512 |
|POLY 1.5 | P=0.258 P=0.512N P=0.520N P=0.510 |
|POLY 6 | P=0.263 P=0.517N P=0.527N P=0.515 |
|LOGISTIC REGRESSION| P=0.089 P=0.274N P=0.407N P=0.275 |
|COCH-ARM / FISHERS | P=0.253 P=0.505N P=0.516N P=0.508 |
|ORDER RESTRICTED | P=0.145 (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 29
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Lymph Node, Mesenteric |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/49 (0%) 0/48 (0%) 2/46 (4%) 2/50 (4%) |
|POLY-3 RATE (b) | 0/44.47 0/42.17 2/40.51 2/45.46 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 4.9% 4.4% |
|TERMINAL (d) | 0/35 (0%) 0/35 (0%) 1/32 (3%) 2/39 (5%) |
|FIRST INCIDENCE | --- --- 669 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.103 (e) P=0.217 P=0.262 |
|POLY 3 | P=0.093 (e) P=0.216 P=0.242 |
|POLY 1.5 | P=0.093 (e) P=0.219 P=0.242 |
|POLY 6 | P=0.094 (e) P=0.215 P=0.242 |
|LOGISTIC REGRESSION| P=0.094 (e) P=0.221 P=0.262 |
|COCH-ARM / FISHERS | P=0.091 (e) P=0.232 P=0.253 |
|ORDER RESTRICTED | P=0.101 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Lymph Node, Mesenteric |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/49 (6%) 2/48 (4%) 3/46 (7%) 0/50 (0%) |
|POLY-3 RATE (b) | 3/44.47 2/42.17 3/40.35 0/45.46 |
|POLY-3 PERCENT (g) | 6.8% 4.7% 7.4% 0.0% |
|TERMINAL (d) | 3/35 (9%) 2/35 (6%) 2/32 (6%) 0/39 (0%) |
|FIRST INCIDENCE | 729 (T) 729 (T) 714 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.100N P=0.500N P=0.615 P=0.102N |
|POLY 3 | P=0.107N P=0.524N P=0.617 P=0.115N |
|POLY 1.5 | P=0.107N P=0.520N P=0.623 P=0.115N |
|POLY 6 | P=0.105N P=0.529N P=0.612 P=0.114N |
|LOGISTIC REGRESSION| P=0.107N P=0.500N P=0.603 (e) |
|COCH-ARM / FISHERS | P=0.110N P=0.510N P=0.631 P=0.117N |
|ORDER RESTRICTED | P=0.091N (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 30
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Lymph Node, Mesenteric |
| Hyperplasia Lymphoid |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 6/49 (12%) 9/48 (19%) 4/46 (9%) 7/50 (14%) |
|POLY-3 RATE (b) | 6/44.47 9/43.18 4/40.88 7/45.46 |
|POLY-3 PERCENT (g) | 13.5% 20.8% 9.8% 15.4% |
|TERMINAL (d) | 6/35 (17%) 7/35 (20%) 3/32 (9%) 7/39 (18%) |
|FIRST INCIDENCE | 729 (T) 547 539 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.456N P=0.283 P=0.423N P=0.585 |
|POLY 3 | P=0.511N P=0.265 P=0.423N P=0.517 |
|POLY 1.5 | P=0.509N P=0.265 P=0.419N P=0.517 |
|POLY 6 | P=0.512N P=0.265 P=0.427N P=0.517 |
|LOGISTIC REGRESSION| P=0.504N P=0.255 P=0.428N P=0.585 |
|COCH-ARM / FISHERS | P=0.511N P=0.273 P=0.411N P=0.516 |
|ORDER RESTRICTED | P=0.439N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Lymph Node: Iliac |
| Hyperplasia Lymphoid |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/16 (19%) 0/9 (0%) 0/7 (0%) 0/4 (0%) |
|POLY-3 RATE (b) | 3/14.27 0/6.81 0/6.09 0/3.25 |
|POLY-3 PERCENT (g) | 21.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 2/7 (29%) 0/2 (0%) 0/2 (0%) 0/2 (0%) |
|FIRST INCIDENCE | 423 --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.119N P=0.282N P=0.282N P=0.280N |
|POLY 3 | P=0.136N P=0.272N P=0.295N P=0.465N |
|POLY 1.5 | P=0.138N P=0.250N P=0.292N P=0.455N |
|POLY 6 | P=0.138N P=0.313N P=0.306N P=0.474N |
|LOGISTIC REGRESSION| P=0.152N P=0.214N P=0.357N P=0.421N |
|COCH-ARM / FISHERS | P=0.144N P=0.243N P=0.316N P=0.491N |
|ORDER RESTRICTED | P=0.324N (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 31
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Mammary Gland |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 9/50 (18%) 4/50 (8%) 4/50 (8%) 2/50 (4%) |
|POLY-3 RATE (b) | 9/46.11 4/43.54 4/44.23 2/45.63 |
|POLY-3 PERCENT (g) | 19.5% 9.2% 9.0% 4.4% |
|TERMINAL (d) | 6/36 (17%) 4/36 (11%) 1/33 (3%) 1/39 (3%) |
|FIRST INCIDENCE | 606 729 (T) 659 686 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.023N* P=0.129N P=0.165N P=0.026N* |
|POLY 3 | P=0.020N* P=0.138N P=0.131N P=0.026N* |
|POLY 1.5 | P=0.021N* P=0.130N P=0.125N P=0.026N* |
|POLY 6 | P=0.020N* P=0.149N P=0.138N P=0.026N* |
|LOGISTIC REGRESSION| P=0.023N* P=0.135N P=0.122N P=0.027N* |
|COCH-ARM / FISHERS | P=0.023N* P=0.117N P=0.117N P=0.026N* |
|ORDER RESTRICTED | P=0.011N* (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Mesentery |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/21 (0%) 2/17 (12%) 0/16 (0%) 0/17 (0%) |
|POLY-3 RATE (b) | 0/17.79 2/15.25 0/14.49 0/15.79 |
|POLY-3 PERCENT (g) | 0.0% 13.1% 0.0% 0.0% |
|TERMINAL (d) | 0/11 (0%) 1/11 (9%) 0/8 (0%) 0/14 (0%) |
|FIRST INCIDENCE | --- 217 --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.384N P=0.238 (e) (e) |
|POLY 3 | P=0.413N P=0.196 (e) (e) |
|POLY 1.5 | P=0.424N P=0.193 (e) (e) |
|POLY 6 | P=0.401N P=0.199 (e) (e) |
|LOGISTIC REGRESSION| P=0.650N P=0.236 (e) (e) |
|COCH-ARM / FISHERS | P=0.444N P=0.193 (e) (e) |
|ORDER RESTRICTED | P=0.235N (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 32
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Mesentery: Fat |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 12/21 (57%) 8/17 (47%) 11/16 (69%) 13/17 (76%) |
|POLY-3 RATE (b) | 12/20.12 8/14.48 11/15.04 13/16.26 |
|POLY-3 PERCENT (g) | 59.7% 55.2% 73.1% 79.9% |
|TERMINAL (d) | 6/11 (55%) 7/11 (64%) 8/8 (100%) 12/14 (86%) |
|FIRST INCIDENCE | 350 674 658 587 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.529 P=0.219N P=0.428 P=0.488N |
|POLY 3 | P=0.082 P=0.535N P=0.315 P=0.164 |
|POLY 1.5 | P=0.084 P=0.489N P=0.336 P=0.169 |
|POLY 6 | P=0.082 P=0.588N P=0.272 P=0.167 |
|LOGISTIC REGRESSION| P=0.124 P=0.395N P=0.336 P=0.177 |
|COCH-ARM / FISHERS | P=0.083 P=0.385N P=0.354 P=0.183 |
|ORDER RESTRICTED | P=0.098 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Ovary |
| Angiectasis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 5/50 (10%) 6/49 (12%) 5/50 (10%) 9/49 (18%) |
|POLY-3 RATE (b) | 5/45.50 6/42.99 5/43.73 9/44.87 |
|POLY-3 PERCENT (g) | 11.0% 14.0% 11.4% 20.1% |
|TERMINAL (d) | 4/36 (11%) 4/35 (11%) 4/33 (12%) 7/38 (18%) |
|FIRST INCIDENCE | 723 640 663 647 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.179 P=0.473 P=0.573 P=0.223 |
|POLY 3 | P=0.144 P=0.460 P=0.605 P=0.184 |
|POLY 1.5 | P=0.144 P=0.467 P=0.615 P=0.184 |
|POLY 6 | P=0.146 P=0.453 P=0.594 P=0.185 |
|LOGISTIC REGRESSION| P=0.145 P=0.445 P=0.580 P=0.178 |
|COCH-ARM / FISHERS | P=0.141 P=0.486 P=0.630N P=0.183 |
|ORDER RESTRICTED | P=0.164 (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 33
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Ovary |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 8/50 (16%) 13/49 (27%) 11/50 (22%) 14/49 (29%) |
|POLY-3 RATE (b) | 8/46.51 13/43.24 11/44.08 14/45.48 |
|POLY-3 PERCENT (g) | 17.2% 30.1% 25.0% 30.8% |
|TERMINAL (d) | 6/36 (17%) 11/35 (31%) 10/33 (30%) 10/38 (26%) |
|FIRST INCIDENCE | 563 547 539 631 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.180 P=0.146 P=0.240 P=0.144 |
|POLY 3 | P=0.129 P=0.116 P=0.259 P=0.098 |
|POLY 1.5 | P=0.130 P=0.127 P=0.278 P=0.100 |
|POLY 6 | P=0.131 P=0.104 P=0.235 P=0.099 |
|LOGISTIC REGRESSION| P=0.135 P=0.134 P=0.287 P=0.103 |
|COCH-ARM / FISHERS | P=0.131 P=0.150 P=0.306 P=0.103 |
|ORDER RESTRICTED | P=0.098 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Ovary: Corpus Luteum |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/50 (6%) 1/49 (2%) 3/50 (6%) 0/49 (0%) |
|POLY-3 RATE (b) | 3/45.47 1/43.17 3/43.91 0/44.46 |
|POLY-3 PERCENT (g) | 6.6% 2.3% 6.8% 0.0% |
|TERMINAL (d) | 3/36 (8%) 0/35 (0%) 2/33 (6%) 0/38 (0%) |
|FIRST INCIDENCE | 729 (T) 521 604 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.132N P=0.314N P=0.625 P=0.111N |
|POLY 3 | P=0.134N P=0.324N P=0.646 P=0.123N |
|POLY 1.5 | P=0.134N P=0.321N P=0.652 P=0.122N |
|POLY 6 | P=0.133N P=0.328N P=0.639 P=0.123N |
|LOGISTIC REGRESSION| P=0.137N P=0.301N P=0.648 (e) |
|COCH-ARM / FISHERS | P=0.137N P=0.316N P=0.661N P=0.125N |
|ORDER RESTRICTED | P=0.079N (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 34
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Ovary: Granulosa Cell |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/50 (0%) 0/49 (0%) 0/50 (0%) 2/49 (4%) |
|POLY-3 RATE (b) | 0/45.47 0/42.54 0/43.48 2/44.46 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 4.5% |
|TERMINAL (d) | 0/36 (0%) 0/35 (0%) 0/33 (0%) 2/38 (5%) |
|FIRST INCIDENCE | --- --- --- 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.053 (e) (e) P=0.250 |
|POLY 3 | P=0.045 * (e) (e) P=0.232 |
|POLY 1.5 | P=0.045 * (e) (e) P=0.233 |
|POLY 6 | P=0.045 * (e) (e) P=0.232 |
|LOGISTIC REGRESSION| (e) (e) (e) P=0.250 |
|COCH-ARM / FISHERS | P=0.045 * (e) (e) P=0.242 |
|ORDER RESTRICTED | P=0.028 * (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Pancreas |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/50 (2%) 2/48 (4%) 2/49 (4%) 0/49 (0%) |
|POLY-3 RATE (b) | 1/45.47 2/42.54 2/43.37 0/45.10 |
|POLY-3 PERCENT (g) | 2.2% 4.7% 4.6% 0.0% |
|TERMINAL (d) | 1/36 (3%) 2/36 (6%) 1/33 (3%) 0/39 (0%) |
|FIRST INCIDENCE | 729 (T) 729 (T) 455 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.282N P=0.500 P=0.482 P=0.484N |
|POLY 3 | P=0.295N P=0.477 P=0.483 P=0.502N |
|POLY 1.5 | P=0.296N P=0.479 P=0.487 P=0.502N |
|POLY 6 | P=0.293N P=0.475 P=0.478 P=0.501N |
|LOGISTIC REGRESSION| P=0.304N P=0.500 P=0.525 (e) |
|COCH-ARM / FISHERS | P=0.299N P=0.485 P=0.492 P=0.505N |
|ORDER RESTRICTED | P=0.212N (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 35
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Pancreas: Acinus |
| Cytoplasmic Alteration |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/50 (0%) 3/48 (6%) 2/49 (4%) 0/49 (0%) |
|POLY-3 RATE (b) | 0/45.47 3/42.69 2/42.70 0/45.10 |
|POLY-3 PERCENT (g) | 0.0% 7.0% 4.7% 0.0% |
|TERMINAL (d) | 0/36 (0%) 2/36 (6%) 1/33 (3%) 0/39 (0%) |
|FIRST INCIDENCE | --- 689 707 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.398N P=0.117 P=0.216 (e) |
|POLY 3 | P=0.408N P=0.107 P=0.223 (e) |
|POLY 1.5 | P=0.409N P=0.108 P=0.227 (e) |
|POLY 6 | P=0.407N P=0.107 P=0.219 (e) |
|LOGISTIC REGRESSION| P=0.408N P=0.109 P=0.219 (e) |
|COCH-ARM / FISHERS | P=0.412N P=0.114 P=0.242 (e) |
|ORDER RESTRICTED | P=0.206 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Parathyroid Gland |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/47 (4%) 0/48 (0%) 0/46 (0%) 1/47 (2%) |
|POLY-3 RATE (b) | 2/42.53 0/41.54 0/40.04 1/42.46 |
|POLY-3 PERCENT (g) | 4.7% 0.0% 0.0% 2.4% |
|TERMINAL (d) | 1/33 (3%) 0/34 (0%) 0/31 (0%) 1/36 (3%) |
|FIRST INCIDENCE | 715 --- --- 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.450N P=0.248N P=0.268N P=0.483N |
|POLY 3 | P=0.458N P=0.242N P=0.251N P=0.501N |
|POLY 1.5 | P=0.460N P=0.239N P=0.247N P=0.500N |
|POLY 6 | P=0.456N P=0.246N P=0.255N P=0.501N |
|LOGISTIC REGRESSION| P=0.459N P=0.247N P=0.255N P=0.499N |
|COCH-ARM / FISHERS | P=0.463N P=0.242N P=0.253N P=0.500N |
|ORDER RESTRICTED | P=0.133N (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 36
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Peripheral Nerve |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/5 (60%) 2/4 (50%) 0/1 (0%) 0/1 (0%) |
|POLY-3 RATE (b) | 3/4.35 2/3.21 0/0.40 0/0.77 |
|POLY-3 PERCENT (g) | 69.0% 62.3% 0.0% 0.0% |
|TERMINAL (d) | 1/1 (100%) 0/0 (0%) 0/0 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 423 318 --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.091N P=0.677 P=0.259N P=0.241N |
|POLY 3 | P=0.348N P=0.719N P=0.723N P=0.546N |
|POLY 1.5 | P=0.292N P=0.673N P=0.620N P=0.519N |
|POLY 6 | P=0.470N P=0.812N P=0.863N P=0.622N |
|LOGISTIC REGRESSION| P=0.209N P=0.600N P=0.527N P=0.516N |
|COCH-ARM / FISHERS | P=0.211N P=0.643N P=0.500N P=0.500N |
|ORDER RESTRICTED | P=0.365N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/49 (2%) 4/50 (8%) 0/49 (0%) 3/49 (6%) |
|POLY-3 RATE (b) | 1/44.47 4/44.27 0/43.23 3/44.63 |
|POLY-3 PERCENT (g) | 2.3% 9.0% 0.0% 6.7% |
|TERMINAL (d) | 1/35 (3%) 2/36 (6%) 0/33 (0%) 3/39 (8%) |
|FIRST INCIDENCE | 729 (T) 547 --- 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.434 P=0.180 P=0.512N P=0.344 |
|POLY 3 | P=0.399 P=0.177 P=0.506N P=0.306 |
|POLY 1.5 | P=0.400 P=0.179 P=0.503N P=0.306 |
|POLY 6 | P=0.398 P=0.175 P=0.509N P=0.307 |
|LOGISTIC REGRESSION| P=0.403 P=0.188 (e) P=0.344 |
|COCH-ARM / FISHERS | P=0.401 P=0.187 P=0.500N P=0.309 |
|ORDER RESTRICTED | P=0.242 (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 37
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis |
| Hyperplasia Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 6/49 (12%) 6/50 (12%) 1/49 (2%) 4/49 (8%) |
|POLY-3 RATE (b) | 6/44.47 6/43.54 1/43.32 4/44.86 |
|POLY-3 PERCENT (g) | 13.5% 13.8% 2.3% 8.9% |
|TERMINAL (d) | 6/35 (17%) 6/36 (17%) 0/33 (0%) 3/39 (8%) |
|FIRST INCIDENCE | 729 (T) 729 (T) 707 669 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.175N P=0.603N P=0.071N P=0.310N |
|POLY 3 | P=0.203N P=0.606 P=0.060N P=0.364N |
|POLY 1.5 | P=0.205N P=0.615 P=0.058N P=0.366N |
|POLY 6 | P=0.200N P=0.596 P=0.062N P=0.359N |
|LOGISTIC REGRESSION| P=0.198N P=0.603N P=0.070N P=0.363N |
|COCH-ARM / FISHERS | P=0.210N P=0.606N P=0.056N P=0.370N |
|ORDER RESTRICTED | P=0.152N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Salivary Glands |
| Hyperplasia Lymphoid |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 25/50 (50%) 22/50 (44%) 26/50 (52%) 20/50 (40%) |
|POLY-3 RATE (b) | 25/47.10 22/45.04 26/44.45 20/46.17 |
|POLY-3 PERCENT (g) | 53.1% 48.9% 58.5% 43.3% |
|TERMINAL (d) | 20/36 (56%) 18/36 (50%) 23/33 (70%) 18/39 (46%) |
|FIRST INCIDENCE | 563 521 539 587 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.151N P=0.373N P=0.327 P=0.142N |
|POLY 3 | P=0.233N P=0.421N P=0.376 P=0.229N |
|POLY 1.5 | P=0.226N P=0.395N P=0.428 P=0.219N |
|POLY 6 | P=0.243N P=0.457N P=0.312 P=0.243N |
|LOGISTIC REGRESSION| P=0.210N P=0.402N P=0.401 P=0.207N |
|COCH-ARM / FISHERS | P=0.229N P=0.344N P=0.500 P=0.211N |
|ORDER RESTRICTED | P=0.250N (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 38
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Skin |
| Edema |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 0/50 (0%) 0/50 (0%) 1/50 (2%) |
|POLY-3 RATE (b) | 2/46.13 0/43.54 0/43.48 1/45.81 |
|POLY-3 PERCENT (g) | 4.3% 0.0% 0.0% 2.2% |
|TERMINAL (d) | 0/36 (0%) 0/36 (0%) 0/33 (0%) 0/39 (0%) |
|FIRST INCIDENCE | 606 --- --- 631 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.456N P=0.256N P=0.258N P=0.497N |
|POLY 3 | P=0.455N P=0.250N P=0.251N P=0.502N |
|POLY 1.5 | P=0.457N P=0.246N P=0.245N P=0.501N |
|POLY 6 | P=0.453N P=0.256N P=0.258N P=0.504N |
|LOGISTIC REGRESSION| P=0.476N P=0.209N P=0.216N P=0.517N |
|COCH-ARM / FISHERS | P=0.461N P=0.247N P=0.247N P=0.500N |
|ORDER RESTRICTED | P=0.135N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Spleen |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 42/50 (84%) 30/49 (61%) 32/48 (67%) 29/50 (58%) |
|POLY-3 RATE (b) | 42/48.25 30/47.57 32/45.99 29/47.84 |
|POLY-3 PERCENT (g) | 87.1% 63.1% 69.6% 60.6% |
|TERMINAL (d) | 31/36 (86%) 20/36 (56%) 20/32 (63%) 23/39 (59%) |
|FIRST INCIDENCE | 563 318 455 472 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.022N* P=0.043N* P=0.197N P=0.006N** |
|POLY 3 | P=0.010N* P=0.005N** P=0.031N* P=0.002N** |
|POLY 1.5 | P=0.010N* P=0.006N** P=0.031N* P=0.002N** |
|POLY 6 | P=0.013N* P=0.005N** P=0.033N* P=0.003N** |
|LOGISTIC REGRESSION| P=0.012N* P=0.012N* P=0.049N* P=0.004N** |
|COCH-ARM / FISHERS | P=0.013N* P=0.010N* P=0.039N* P=0.004N** |
|ORDER RESTRICTED | P=0.002N** (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 39
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Spleen |
| Hyperplasia Lymphoid |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/50 (6%) 1/49 (2%) 2/48 (4%) 3/50 (6%) |
|POLY-3 RATE (b) | 3/45.47 1/43.17 2/41.61 3/45.46 |
|POLY-3 PERCENT (g) | 6.6% 2.3% 4.8% 6.6% |
|TERMINAL (d) | 3/36 (8%) 1/36 (3%) 2/32 (6%) 3/39 (8%) |
|FIRST INCIDENCE | 729 (T) 729 (T) 729 (T) 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.510 P=0.305N P=0.554N P=0.626N |
|POLY 3 | P=0.484 P=0.324N P=0.540N P=0.662 |
|POLY 1.5 | P=0.483 P=0.321N P=0.532N P=0.662N |
|POLY 6 | P=0.485 P=0.328N P=0.551N P=0.662 |
|LOGISTIC REGRESSION| P=0.510 P=0.305N P=0.554N P=0.626N |
|COCH-ARM / FISHERS | P=0.478 P=0.316N P=0.520N P=0.661N |
|ORDER RESTRICTED | P=0.509 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Spleen |
| Pigmentation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 29/50 (58%) 22/49 (45%) 30/48 (63%) 27/50 (54%) |
|POLY-3 RATE (b) | 29/47.49 22/44.67 30/44.68 27/47.62 |
|POLY-3 PERCENT (g) | 61.1% 49.3% 67.2% 56.7% |
|TERMINAL (d) | 23/36 (64%) 19/36 (53%) 20/32 (63%) 22/39 (56%) |
|FIRST INCIDENCE | 350 318 486 424 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.449N P=0.135N P=0.288 P=0.305N |
|POLY 3 | P=0.535N P=0.172N P=0.346 P=0.411N |
|POLY 1.5 | P=0.533 P=0.159N P=0.359 P=0.414N |
|POLY 6 | P=0.519N P=0.193N P=0.345 P=0.409N |
|LOGISTIC REGRESSION| P=0.515 P=0.152N P=0.354 P=0.419N |
|COCH-ARM / FISHERS | P=0.505 P=0.135N P=0.402 P=0.420N |
|ORDER RESTRICTED | P=0.404 (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 40
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Spleen: Lymphoid Follicle |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 5/50 (10%) 8/49 (16%) 13/48 (27%) 14/50 (28%) |
|POLY-3 RATE (b) | 5/45.97 8/43.17 13/41.81 14/45.57 |
|POLY-3 PERCENT (g) | 10.9% 18.5% 31.1% 30.7% |
|TERMINAL (d) | 4/36 (11%) 8/36 (22%) 11/32 (34%) 13/39 (33%) |
|FIRST INCIDENCE | 581 729 (T) 701 703 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.019 * P=0.272 P=0.018 * P=0.030 * |
|POLY 3 | P=0.010 * P=0.235 P=0.017 * P=0.016 * |
|POLY 1.5 | P=0.011 * P=0.244 P=0.020 * P=0.018 * |
|POLY 6 | P=0.009 ** P=0.224 P=0.014 * P=0.015 * |
|LOGISTIC REGRESSION| P=0.012 * P=0.238 P=0.017 * P=0.020 * |
|COCH-ARM / FISHERS | P=0.012 * P=0.264 P=0.026 * P=0.020 * |
|ORDER RESTRICTED | P=0.011 * (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Edema |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 1/49 (2%) 2/50 (4%) 0/50 (0%) |
|POLY-3 RATE (b) | 2/46.04 1/43.67 2/44.10 0/45.46 |
|POLY-3 PERCENT (g) | 4.3% 2.3% 4.5% 0.0% |
|TERMINAL (d) | 0/36 (0%) 0/36 (0%) 0/33 (0%) 0/39 (0%) |
|FIRST INCIDENCE | 563 581 583 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.206N P=0.519N P=0.662 P=0.242N |
|POLY 3 | P=0.200N P=0.518N P=0.678 P=0.240N |
|POLY 1.5 | P=0.199N P=0.515N P=0.684 P=0.239N |
|POLY 6 | P=0.201N P=0.522N P=0.671 P=0.242N |
|LOGISTIC REGRESSION| P=0.206N P=0.460N P=0.667N P=0.245N |
|COCH-ARM / FISHERS | P=0.199N P=0.508N P=0.691N P=0.247N |
|ORDER RESTRICTED | P=0.157N (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 41
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/50 (0%) 4/49 (8%) 0/50 (0%) 1/50 (2%) |
|POLY-3 RATE (b) | 0/45.47 4/45.38 0/43.48 1/46.10 |
|POLY-3 PERCENT (g) | 0.0% 8.8% 0.0% 2.2% |
|TERMINAL (d) | 0/36 (0%) 0/36 (0%) 0/33 (0%) 0/39 (0%) |
|FIRST INCIDENCE | --- 318 --- 522 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.529N P=0.063 (e) P=0.500 |
|POLY 3 | P=0.526N P=0.060 (e) P=0.503 |
|POLY 1.5 | P=0.527N P=0.059 (e) P=0.502 |
|POLY 6 | P=0.525N P=0.061 (e) P=0.504 |
|LOGISTIC REGRESSION| P=0.617N P=0.085 (e) P=0.438 |
|COCH-ARM / FISHERS | P=0.528N P=0.056 (e) P=0.500 |
|ORDER RESTRICTED | P=0.212 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Ulcer |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/50 (0%) 0/49 (0%) 2/50 (4%) 0/50 (0%) |
|POLY-3 RATE (b) | 0/45.47 0/43.17 2/44.06 0/45.46 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 4.5% 0.0% |
|TERMINAL (d) | 0/36 (0%) 0/36 (0%) 0/33 (0%) 0/39 (0%) |
|FIRST INCIDENCE | --- --- 583 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.594 (e) P=0.223 (e) |
|POLY 3 | P=0.603 (e) P=0.230 (e) |
|POLY 1.5 | P=0.602 (e) P=0.233 (e) |
|POLY 6 | P=0.605 (e) P=0.227 (e) |
|LOGISTIC REGRESSION| P=0.589 (e) P=0.253 (e) |
|COCH-ARM / FISHERS | P=0.596 (e) P=0.247 (e) |
|ORDER RESTRICTED | P=0.241 (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 42
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Stomach, Forestomach: Epithelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 3/49 (6%) 4/50 (8%) 2/50 (4%) |
|POLY-3 RATE (b) | 2/45.99 3/44.89 4/43.57 2/46.70 |
|POLY-3 PERCENT (g) | 4.4% 6.7% 9.2% 4.3% |
|TERMINAL (d) | 0/36 (0%) 0/36 (0%) 3/33 (9%) 0/39 (0%) |
|FIRST INCIDENCE | 581 318 707 522 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.549N P=0.483 P=0.298 P=0.690 |
|POLY 3 | P=0.551N P=0.489 P=0.312 P=0.688N |
|POLY 1.5 | P=0.553N P=0.489 P=0.323 P=0.690N |
|POLY 6 | P=0.549N P=0.488 P=0.300 P=0.687N |
|LOGISTIC REGRESSION| P=0.574 P=0.599 P=0.330 P=0.672 |
|COCH-ARM / FISHERS | P=0.559N P=0.490 P=0.339 P=0.691N |
|ORDER RESTRICTED | P=0.493N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Stomach, Glandular |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 0/49 (0%) 2/49 (4%) 0/50 (0%) |
|POLY-3 RATE (b) | 2/45.63 0/43.17 2/42.87 0/45.46 |
|POLY-3 PERCENT (g) | 4.4% 0.0% 4.7% 0.0% |
|TERMINAL (d) | 1/36 (3%) 0/36 (0%) 1/33 (3%) 0/39 (0%) |
|FIRST INCIDENCE | 689 --- 659 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.243N P=0.251N P=0.663 P=0.234N |
|POLY 3 | P=0.242N P=0.250N P=0.671 P=0.238N |
|POLY 1.5 | P=0.243N P=0.247N P=0.677 P=0.237N |
|POLY 6 | P=0.241N P=0.253N P=0.664 P=0.239N |
|LOGISTIC REGRESSION| P=0.247N P=0.247N P=0.682 P=0.237N |
|COCH-ARM / FISHERS | P=0.247N P=0.253N P=0.684 P=0.247N |
|ORDER RESTRICTED | P=0.116N (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 43
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Stomach, Glandular |
| Edema |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 0/49 (0%) 1/49 (2%) 1/50 (2%) |
|POLY-3 RATE (b) | 2/46.01 0/43.17 1/43.10 1/45.63 |
|POLY-3 PERCENT (g) | 4.4% 0.0% 2.3% 2.2% |
|TERMINAL (d) | 1/36 (3%) 0/36 (0%) 0/33 (0%) 0/39 (0%) |
|FIRST INCIDENCE | 563 --- 583 686 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.494N P=0.247N P=0.520N P=0.496N |
|POLY 3 | P=0.494N P=0.252N P=0.523N P=0.503N |
|POLY 1.5 | P=0.495N P=0.248N P=0.517N P=0.501N |
|POLY 6 | P=0.492N P=0.255N P=0.530N P=0.504N |
|LOGISTIC REGRESSION| P=0.514N P=0.220N P=0.469N P=0.508N |
|COCH-ARM / FISHERS | P=0.499N P=0.253N P=0.508N P=0.500N |
|ORDER RESTRICTED | P=0.282N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Thymus |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 9/49 (18%) 3/49 (6%) 6/50 (12%) 4/47 (9%) |
|POLY-3 RATE (b) | 9/47.71 3/44.86 6/45.14 4/44.81 |
|POLY-3 PERCENT (g) | 18.9% 6.7% 13.3% 8.9% |
|TERMINAL (d) | 2/36 (6%) 1/36 (3%) 1/33 (3%) 0/37 (0%) |
|FIRST INCIDENCE | 350 318 539 424 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.173N P=0.085N P=0.357N P=0.133N |
|POLY 3 | P=0.173N P=0.074N P=0.328N P=0.141N |
|POLY 1.5 | P=0.174N P=0.068N P=0.308N P=0.137N |
|POLY 6 | P=0.172N P=0.085N P=0.352N P=0.147N |
|LOGISTIC REGRESSION| P=0.146N P=0.029N* P=0.187N P=0.069N |
|COCH-ARM / FISHERS | P=0.176N P=0.060N P=0.274N P=0.133N |
|ORDER RESTRICTED | P=0.105N (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 44
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Thymus |
| Hyperplasia Lymphoid |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/49 (2%) 3/49 (6%) 4/50 (8%) 2/47 (4%) |
|POLY-3 RATE (b) | 1/44.77 3/43.51 4/43.48 2/42.63 |
|POLY-3 PERCENT (g) | 2.2% 6.9% 9.2% 4.7% |
|TERMINAL (d) | 1/36 (3%) 3/36 (8%) 4/33 (12%) 2/37 (5%) |
|FIRST INCIDENCE | 729 (T) 729 (T) 729 (T) 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.466 P=0.305 P=0.153 P=0.510 |
|POLY 3 | P=0.434 P=0.295 P=0.170 P=0.483 |
|POLY 1.5 | P=0.436 P=0.300 P=0.176 P=0.484 |
|POLY 6 | P=0.433 P=0.288 P=0.161 P=0.481 |
|LOGISTIC REGRESSION| P=0.466 P=0.305 P=0.153 P=0.510 |
|COCH-ARM / FISHERS | P=0.437 P=0.309 P=0.187 P=0.484 |
|ORDER RESTRICTED | P=0.272 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Thyroid Gland |
| Degeneration Cystic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 26/50 (52%) 17/49 (35%) 12/49 (24%) 11/50 (22%) |
|POLY-3 RATE (b) | 26/48.04 17/43.65 12/43.33 11/46.04 |
|POLY-3 PERCENT (g) | 54.1% 39.0% 27.7% 23.9% |
|TERMINAL (d) | 19/36 (53%) 14/35 (40%) 9/33 (27%) 9/39 (23%) |
|FIRST INCIDENCE | 423 521 663 631 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001N** P=0.085N P=0.014N* P=0.002N** |
|POLY 3 | P<0.001N** P=0.104N P=0.008N** P=0.002N** |
|POLY 1.5 | P<0.001N** P=0.087N P=0.006N** P<0.001N** |
|POLY 6 | P<0.001N** P=0.126N P=0.011N* P=0.002N** |
|LOGISTIC REGRESSION| P<0.001N** P=0.074N P=0.005N** P=0.002N** |
|COCH-ARM / FISHERS | P<0.001N** P=0.062N P=0.004N** P=0.002N** |
|ORDER RESTRICTED | P<0.001N** (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 45
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 6/50 (12%) 1/49 (2%) 5/49 (10%) 1/50 (2%) |
|POLY-3 RATE (b) | 6/46.00 1/42.54 5/43.29 1/45.46 |
|POLY-3 PERCENT (g) | 13.0% 2.4% 11.6% 2.2% |
|TERMINAL (d) | 4/36 (11%) 1/35 (3%) 3/33 (9%) 1/39 (3%) |
|FIRST INCIDENCE | 649 729 (T) 604 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.089N P=0.069N P=0.552N P=0.053N |
|POLY 3 | P=0.087N P=0.069N P=0.542N P=0.058N |
|POLY 1.5 | P=0.089N P=0.066N P=0.531N P=0.057N |
|POLY 6 | P=0.086N P=0.074N P=0.556N P=0.059N |
|LOGISTIC REGRESSION| P=0.094N P=0.067N P=0.523N P=0.058N |
|COCH-ARM / FISHERS | P=0.095N P=0.059N P=0.514N P=0.056N |
|ORDER RESTRICTED | P=0.028N* (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Urinary Bladder |
| Edema |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/50 (0%) 2/49 (4%) 0/48 (0%) 1/50 (2%) |
|POLY-3 RATE (b) | 0/45.47 2/43.54 0/41.61 1/45.81 |
|POLY-3 PERCENT (g) | 0.0% 4.6% 0.0% 2.2% |
|TERMINAL (d) | 0/36 (0%) 0/35 (0%) 0/32 (0%) 0/39 (0%) |
|FIRST INCIDENCE | --- 521 --- 631 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.544 P=0.237 (e) P=0.504 |
|POLY 3 | P=0.539 P=0.227 (e) P=0.501 |
|POLY 1.5 | P=0.539 P=0.229 (e) P=0.501 |
|POLY 6 | P=0.540 P=0.226 (e) P=0.502 |
|LOGISTIC REGRESSION| P=0.506 P=0.285 (e) P=0.488 |
|COCH-ARM / FISHERS | P=0.539 P=0.242 (e) P=0.500 |
|ORDER RESTRICTED | P=0.308 (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 46
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Urinary Bladder |
| Hyperplasia Lymphoid |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 11/50 (22%) 7/49 (14%) 4/48 (8%) 10/50 (20%) |
|POLY-3 RATE (b) | 11/45.47 7/43.27 4/41.61 10/45.46 |
|POLY-3 PERCENT (g) | 24.2% 16.2% 9.6% 22.0% |
|TERMINAL (d) | 11/36 (31%) 5/35 (14%) 4/32 (13%) 10/39 (26%) |
|FIRST INCIDENCE | 729 (T) 547 729 (T) 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.431N P=0.239N P=0.068N P=0.415N |
|POLY 3 | P=0.495N P=0.250N P=0.063N P=0.500N |
|POLY 1.5 | P=0.494N P=0.246N P=0.059N P=0.499N |
|POLY 6 | P=0.496N P=0.254N P=0.068N P=0.501N |
|LOGISTIC REGRESSION| P=0.484N P=0.270N P=0.068N P=0.415N |
|COCH-ARM / FISHERS | P=0.498N P=0.232N P=0.054N P=0.500N |
|ORDER RESTRICTED | P=0.242N (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Uterus |
| Angiectasis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/50 (0%) 3/50 (6%) 1/50 (2%) 0/50 (0%) |
|POLY-3 RATE (b) | 0/45.47 3/43.54 1/43.48 0/45.46 |
|POLY-3 PERCENT (g) | 0.0% 6.9% 2.3% 0.0% |
|TERMINAL (d) | 0/36 (0%) 3/36 (8%) 1/33 (3%) 0/39 (0%) |
|FIRST INCIDENCE | --- 729 (T) 729 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.348N P=0.121 P=0.483 (e) |
|POLY 3 | P=0.371N P=0.111 P=0.491 (e) |
|POLY 1.5 | P=0.369N P=0.114 P=0.495 (e) |
|POLY 6 | P=0.374N P=0.108 P=0.486 (e) |
|LOGISTIC REGRESSION| (e) P=0.121 P=0.483 (e) |
|COCH-ARM / FISHERS | P=0.366N P=0.121 P=0.500 (e) |
|ORDER RESTRICTED | P=0.211N (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 47
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Uterus |
| Hyperplasia Cystic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 45/50 (90%) 45/50 (90%) 43/50 (86%) 46/50 (92%) |
|POLY-3 RATE (b) | 45/48.59 45/48.66 43/48.08 46/48.24 |
|POLY-3 PERCENT (g) | 92.6% 92.5% 89.4% 95.4% |
|TERMINAL (d) | 34/36 (94%) 33/36 (92%) 31/33 (94%) 38/39 (97%) |
|FIRST INCIDENCE | 423 318 455 522 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.387N P=0.524 P=0.442 P=0.429N |
|POLY 3 | P=0.374 P=0.646N P=0.419N P=0.440 |
|POLY 1.5 | P=0.414 P=0.637 P=0.399N P=0.467 |
|POLY 6 | P=0.338 P=0.621N P=0.455N P=0.424 |
|LOGISTIC REGRESSION| P=0.502 P=0.539 P=0.454N P=0.517 |
|COCH-ARM / FISHERS | P=0.453 P=0.630N P=0.380N P=0.500 |
|ORDER RESTRICTED | P=0.355 (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Uterus |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/50 (4%) 2/50 (4%) 0/50 (0%) 1/50 (2%) |
|POLY-3 RATE (b) | 2/45.53 2/43.54 0/43.48 1/45.46 |
|POLY-3 PERCENT (g) | 4.4% 4.6% 0.0% 2.2% |
|TERMINAL (d) | 1/36 (3%) 2/36 (6%) 0/33 (0%) 1/39 (3%) |
|FIRST INCIDENCE | 715 729 (T) --- 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.285N P=0.684 P=0.271N P=0.484N |
|POLY 3 | P=0.298N P=0.678 P=0.248N P=0.501N |
|POLY 1.5 | P=0.297N P=0.683 P=0.243N P=0.500N |
|POLY 6 | P=0.299N P=0.672 P=0.253N P=0.501N |
|LOGISTIC REGRESSION| P=0.294N P=0.669 P=0.255N P=0.500N |
|COCH-ARM / FISHERS | P=0.296N P=0.691N P=0.247N P=0.500N |
|ORDER RESTRICTED | P=0.259N (e) (e) (e) |
|=================================================================================================================================|
Date: 03/25/03 EXPERIMENT: 96018 TEST: 04 Page 48
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - WATER DISINFECTION BYPRODUCTS (BROMODICHL
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 MG/L 175 MG/L 350 MG/L 700 MG/L |
| | |
|=================================================================================================================================|
| |
|Uterus |
| Metaplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/50 (0%) 1/50 (2%) 2/50 (4%) 2/50 (4%) |
|POLY-3 RATE (b) | 0/45.47 1/43.54 2/43.48 2/45.46 |
|POLY-3 PERCENT (g) | 0.0% 2.3% 4.6% 4.4% |
|TERMINAL (d) | 0/36 (0%) 1/36 (3%) 2/33 (6%) 2/39 (5%) |
|FIRST INCIDENCE | --- 729 (T) 729 (T) 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.181 P=0.500 P=0.219 P=0.256 |
|POLY 3 | P=0.163 P=0.491 P=0.227 P=0.237 |
|POLY 1.5 | P=0.163 P=0.494 P=0.231 P=0.237 |
|POLY 6 | P=0.164 P=0.488 P=0.222 P=0.237 |
|LOGISTIC REGRESSION| (e) P=0.500 P=0.219 P=0.256 |
|COCH-ARM / FISHERS | P=0.160 P=0.500 P=0.247 P=0.247 |
|ORDER RESTRICTED | P=0.147 (e) (e) (e) |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Number of tumor-bearing animals / Poly-3 number
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death.
Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e) Value of Statistic cannot be computed.
(g) Poly-3 adjusted lifetime tumor incidence.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).