TDMS Study 88138-02 Pathology Tables
NTP Experiment-Test: 88138-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY BENZOPHENONE Date: 10/25/04
Route: DOSED FEED Time: 13:30:43
Facility: Battelle Columbus Laboratory
Chemical CAS #: 119-61-9
Lock Date: 08/17/93
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 88138-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY BENZOPHENONE Date: 10/25/04
Route: DOSED FEED Time: 13:30:43
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B6C3F1 MICE FEMALE 0% 0.125% 0.25% 0.5% 1.0% 2.0%
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DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Moribund Sacrifice 3
Natural Death 1
Survivors
Terminal Sacrifice 10 10 10 10 10 6
Animals Examined Microscopically 10 10 10 10 10 10
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ALIMENTARY SYSTEM
Liver (10) (10) (10) (10) (10) (10)
Inflammation, Chronic Active 8 (80%) 9 (90%) 9 (90%) 9 (90%) 9 (90%) 3 (30%)
Centrilobular, Hypertrophy 3 (30%) 9 (90%) 10 (100%) 10 (100%) 10 (100%) 10 (100%)
Hepatocyte, Vacuolization Cytoplasmic 2 (20%) 9 (90%) 1 (10%)
Salivary Glands (10) (10)
Infiltration Cellular, Mononuclear Cell 1 (10%)
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CARDIOVASCULAR SYSTEM
Heart (10) (10)
Myocardium, Mineralization 2 (20%)
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ENDOCRINE SYSTEM
None
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Ovary (10) (1) (10)
Cyst 1 (100%)
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a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 88138-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY BENZOPHENONE Date: 10/25/04
Route: DOSED FEED Time: 13:30:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0% 0.125% 0.25% 0.5% 1.0% 2.0%
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Spleen (10) (10)
Lymphoid Follicle, Depletion Cellular 1 (10%)
Thymus (10) (7)
Atrophy 5 (71%)
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INTEGUMENTARY SYSTEM
None
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MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
Brain (10) (10)
Cyst Epithelial Inclusion 1 (10%)
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RESPIRATORY SYSTEM
Lung (10) (1) (10)
Arteriole, Vasculitis, Acute 1 (100%)
Nose (10) (10)
Inflammation, Chronic Active 5 (50%)
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SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 88138-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY BENZOPHENONE Date: 10/25/04
Route: DOSED FEED Time: 13:30:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0% 0.125% 0.25% 0.5% 1.0% 2.0%
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Accidently Killed 1
Moribund Sacrifice 6
Natural Death 4
Survivors
Terminal Sacrifice 10 9 10 10 10
Animals Examined Microscopically 10 10 10 10 10 10
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ALIMENTARY SYSTEM
Liver (10) (10) (10) (10) (10) (10)
Inflammation, Chronic Active 5 (50%) 4 (40%) 8 (80%) 8 (80%) 5 (50%) 1 (10%)
Centrilobular, Hypertrophy 3 (30%) 8 (80%) 10 (100%) 10 (100%) 10 (100%) 10 (100%)
Hepatocyte, Vacuolization Cytoplasmic 3 (30%)
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CARDIOVASCULAR SYSTEM
Heart (10) (1) (10) (10)
Myocardium, Mineralization 2 (20%)
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ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 88138-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY BENZOPHENONE Date: 10/25/04
Route: DOSED FEED Time: 13:30:43
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0% 0.125% 0.25% 0.5% 1.0% 2.0%
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Spleen (10) (1) (10) (10)
Lymphoid Follicle, Depletion Cellular 5 (50%)
Thymus (8) (1) (10) (8)
Atrophy 7 (88%)
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INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (1) (10) (10)
Alveolus, Hemorrhage, Acute 1 (100%)
Arteriole, Embolus 1 (100%)
Nose (10) (1) (10) (10)
Inflammation, Chronic Active 1 (10%)
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SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
Kidney (10) (1) (10) (10)
Inflammation, Chronic Active 1 (10%)
Renal Tubule, Regeneration 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
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