TDMS Study 05135-05 Pathology Tables
NTP Experiment-Test: 05135-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:12:45
Facility: Battelle Northwest
Chemical CAS #: 78-79-5
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05135-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:12:45
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FISCHER 344 RATS MALE CONTROL 70 PPM 220 PPM 700 PPM 2200 PPM 7000 PPM
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DISPOSITION SUMMARY
Animals Initially In Study 40 40 40 40 40 40
Scheduled Sacrifice 10 10 10 10 10 10
Early Deaths
Natural Death 1
Survivors
Terminal Sacrifice 30 30 29 30 30 30
Animals Examined Microscopically 40 40 40 40 40 40
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ALIMENTARY SYSTEM
Intestine Small, Jejunum (40) (10) (10) (10) (10) (40)
Hemorrhage, Multifocal 1 (3%)
Inflammation, Multifocal, Suppurative 1 (3%)
Intestine Small, Ileum (40) (10) (10) (10) (10) (40)
Hyperplasia, Lymphoid 1 (3%)
Liver (40) (15) (22) (15) (17) (40)
Clear Cell Focus 1 (5%)
Fatty Change 1 (3%) 3 (14%) 4 (27%)
Fatty Change, Focal 1 (6%)
Fatty Change, Multifocal 2 (9%) 1 (7%)
Fibrosis 1 (3%) 1 (6%) 1 (3%)
Fibrosis, Focal 1 (6%)
Fibrosis, Multifocal 1 (3%) 1 (5%) 1 (3%)
Hepatodiaphragmatic Nodule 5 (13%) 9 (60%) 8 (36%) 4 (27%) 8 (47%) 6 (15%)
Inflammation 1 (3%)
Inflammation, Focal 1 (3%)
Inflammation, Multifocal 2 (5%)
Necrosis, Focal 1 (5%) 1 (3%)
Necrosis, Multifocal 1 (3%) 2 (9%) 3 (8%)
Sinusoid, Congestion, Focal 1 (3%)
Mesentery (1) (2) (2) (2) (2) (1)
Accessory Spleen 1 (100%)
Congestion 1 (50%)
Necrosis 1 (100%) 2 (100%) 2 (100%) 2 (100%)
Pancreas (40) (10) (11) (10) (10) (40)
Accessory Spleen 1 (3%)
Atrophy 8 (20%) 9 (23%)
Atrophy, Focal 1 (3%)
Atrophy, Multifocal 1 (3%) 1 (3%)
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05135-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:12:45
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 70 PPM 220 PPM 700 PPM 2200 PPM 7000 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Infiltration Cellular, Focal, Mixed Cell 1 (3%)
Infiltration Cellular, Mixed Cell 2 (5%) 2 (5%)
Stomach, Forestomach (40) (10) (10) (10) (10) (40)
Infiltration Cellular, Mixed Cell 1 (3%)
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CARDIOVASCULAR SYSTEM
Heart (40) (10) (11) (10) (10) (40)
Cardiomyopathy 1 (3%) 12 (30%)
Cardiomyopathy, Focal 2 (5%)
Cardiomyopathy, Multifocal 14 (35%) 2 (5%)
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ENDOCRINE SYSTEM
Adrenal Cortex (40) (10) (11) (10) (10) (40)
Vacuolization Cytoplasmic, Focal 1 (3%)
Islets, Pancreatic (40) (10) (11) (10) (10) (40)
Hyperplasia 4 (10%) 6 (15%)
Pituitary Gland (40) (18) (14) (14) (14) (40)
Hemorrhage, Focal 1 (7%)
Hyperplasia 11 (28%) 1 (6%) 1 (7%) 11 (28%)
Pars Distalis, Cyst 1 (3%) 1 (7%) 2 (5%)
Thyroid Gland (40) (10) (10) (10) (10) (40)
Cyst 2 (5%) 3 (8%)
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Epididymis (40) (10) (12) (10) (11) (40)
Hemorrhage 1 (3%)
Hypospermia 1 (3%)
Inflammation, Chronic 1 (3%) 1 (3%)
Preputial Gland (39) (10) (10) (12) (10) (40)
Hyperplasia 1 (3%)
Infiltration Cellular, Mixed Cell 2 (5%) 2 (17%) 1 (3%)
Inflammation, Suppurative 3 (8%) 2 (17%)
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05135-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:12:45
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 70 PPM 220 PPM 700 PPM 2200 PPM 7000 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Prostate (40) (10) (11) (10) (10) (40)
Corpora Amylacea 1 (3%) 2 (5%)
Inflammation, Suppurative 2 (5%)
Testes (40) (40) (40) (40) (39) (40)
Degeneration 1 (3%) 1 (3%)
Granuloma 1 (3%)
Inflammation 1 (3%)
Interstitial Cell, Hyperplasia 26 (65%) 31 (78%) 31 (78%) 31 (78%) 32 (82%) 40 (100%)
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HEMATOPOIETIC SYSTEM
Lymph Node (1) (2)
Pancreatic, Congestion 1 (100%) 1 (50%)
Lymph Node, Bronchial (32) (10) (11) (10) (11) (37)
Congestion 17 (53%) 19 (51%)
Hyperplasia 1 (3%) 1 (9%) 6 (16%)
Lymph Node, Mandibular (35) (10) (12) (11) (10) (40)
Congestion 1 (3%) 1 (9%) 3 (8%)
Hyperplasia 8 (23%) 1 (8%) 5 (13%)
Lymph Node, Mediastinal (35) (15) (12) (11) (10) (30)
Congestion 20 (57%) 3 (20%) 1 (8%) 1 (10%) 17 (57%)
Hyperplasia 5 (14%) 4 (27%) 1 (8%) 1 (9%) 8 (27%)
Pigmentation, Hemosiderin 6 (17%) 2 (7%)
Spleen (40) (13) (12) (13) (13) (40)
Accessory Spleen 2 (5%) 1 (8%) 1 (8%) 2 (15%) 3 (23%) 2 (5%)
Capsule, Hyperplasia, Lymphoid 1 (8%)
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INTEGUMENTARY SYSTEM
Mammary Gland (3) (10) (10) (11) (10) (3)
Hyperplasia 1 (33%) 2 (67%)
Skin (40) (10) (11) (12) (10) (40)
Inflammation, Chronic 1 (8%)
Subcutaneous Tissue, Hemorrhage 1 (9%)
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MUSCULOSKELETAL SYSTEM
None
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a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05135-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:12:45
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 70 PPM 220 PPM 700 PPM 2200 PPM 7000 PPM
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (40) (11) (11) (10) (10) (40)
Hemorrhage 1 (9%)
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RESPIRATORY SYSTEM
Larynx (40) (10) (10) (10) (10) (40)
Infiltration Cellular, Mixed Cell 1 (3%) 3 (8%)
Lung (40) (40) (40) (40) (40) (40)
Congestion 1 (3%) 1 (3%)
Fibrosis, Multifocal 1 (3%)
Hemorrhage 5 (13%) 10 (25%) 11 (28%) 10 (25%) 10 (25%) 5 (13%)
Hemorrhage, Multifocal 35 (88%) 30 (75%) 26 (65%) 24 (60%) 22 (55%) 35 (88%)
Alveolar Epithelium, Hyperplasia 3 (8%) 1 (3%) 1 (3%)
Alveolar Epithelium, Hyperplasia, Focal 1 (3%) 2 (5%)
Alveolar Epithelium, Hyperplasia, Multifocal 2 (5%) 15 (38%) 13 (33%) 11 (28%) 11 (28%) 3 (8%)
Alveolus, Hemorrhage 2 (5%) 1 (3%) 3 (8%)
Alveolus, Infiltration Cellular, Focal,
Histiocyte 2 (5%) 1 (3%) 1 (3%) 1 (3%) 1 (3%)
Alveolus, Infiltration Cellular, Multifocal,
Histiocyte 2 (5%) 17 (43%) 18 (45%) 16 (40%) 15 (38%) 18 (45%)
Alveolus, Infiltration Cellular, Histiocyte 1 (3%) 2 (5%)
Alveolus, Inflammation, Granulomatous 1 (3%)
Peribronchial, Hyperplasia, Focal, Lymphoid 2 (5%) 3 (8%) 4 (10%)
Peribronchial, Hyperplasia, Lymphoid 1 (3%)
Peribronchial, Hyperplasia, Lymphoid,
Multifocal 5 (13%) 8 (20%) 7 (18%) 7 (18%) 4 (10%) 1 (3%)
Perivascular, Hyperplasia, Focal, Lymphoid 1 (3%) 1 (3%) 2 (5%) 2 (5%) 2 (5%)
Perivascular, Hyperplasia, Lymphoid,
Multifocal 15 (38%) 23 (58%) 25 (63%) 20 (50%) 17 (43%) 23 (58%)
Nose (40) (10) (11) (10) (10) (40)
Turbinate, Hemorrhage 1 (9%)
Turbinate, Infiltration Cellular, Multifocal,
Mixed Cell 1 (3%)
Turbinate, Infiltration Cellular, Mixed Cell 1 (3%) 1 (3%)
Turbinate, Inflammation, Suppurative 1 (3%) 1 (3%)
Trachea (40) (10) (10) (11) (10) (40)
Infiltration Cellular, Mononuclear Cell,
Multifocal 1 (3%)
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a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05135-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:12:45
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 70 PPM 220 PPM 700 PPM 2200 PPM 7000 PPM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (40) (10) (11) (11) (11) (40)
Cataract 1 (9%) 1 (9%)
Retina, Degeneration 1 (9%) 1 (9%)
Harderian Gland (5) (6)
Hemorrhage 1 (20%)
Hyperplasia, Lymphoid 4 (80%) 3 (50%)
Hyperplasia, Lymphoid, Multifocal 3 (50%)
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URINARY SYSTEM
Kidney (40) (10) (12) (12) (16) (40)
Nephropathy, Chronic 1 (8%)
Bilateral, Cyst 1 (8%)
Bilateral, Nephropathy, Chronic 23 (58%) 1 (8%) 1 (8%) 6 (38%) 29 (73%)
Urinary Bladder (40) (11) (13) (10) (17) (40)
Calculus Micro Observation Only 2 (5%) 3 (23%) 5 (29%) 12 (30%)
a Number of animals examined microscopically at site and number of animals with lesion
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