TDMS Study 05135-06 Pathology Tables
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
Facility: Battelle Northwest
Chemical CAS #: 78-79-5
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to CID number
Page 1
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
_____________________________________________________________________________________________________________________
| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 1| 1| 1| 3| 1| 1|
DAY ON TEST | 7| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 7| 7| 7| 7| 7| 7| 8| 8| 8| 7| 8| 8|
| 3| 9| 3| 3| 3| 3| 3| 3| 1| 1| 3| 1| 0| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + A + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + M + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X |
|__________________________________________________________________________|
Mesentery | + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pharynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tooth | |
__________________________________________|__________________________________________________________________________|
Page 2
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
_____________________________________________________________________________________________________________________
| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 1| 1| 1| 3| 1| 1|
DAY ON TEST | 7| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 7| 7| 7| 7| 7| 7| 8| 8| 8| 7| 8| 8|
| 3| 9| 3| 3| 3| 3| 3| 3| 1| 1| 3| 1| 0| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Odontoma | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + M + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + M + + M + + M + + + M + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Penis | + |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Prostate | + M + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 3
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
_____________________________________________________________________________________________________________________
| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 1| 1| 1| 3| 1| 1|
DAY ON TEST | 7| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 7| 7| 7| 7| 7| 7| 8| 8| 8| 7| 8| 8|
| 3| 9| 3| 3| 3| 3| 3| 3| 1| 1| 3| 1| 0| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node | + |
|__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + M M + + + + + + + + M M M + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M + + + M M + M M + + + + M + + M + + M + + M +|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mediastinal | M + + M M M M + + + M M + M M + + + M + + M M M +|
Lymphoma Malignant Lymphocytic | X |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
_____________________________________________________________________________________________________________________
| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 1| 1| 1| 3| 1| 1|
DAY ON TEST | 7| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 9| 7| 7| 7| 7| 7| 7| 8| 8| 8| 7| 8| 8|
| 3| 9| 3| 3| 3| 3| 3| 3| 1| 1| 3| 1| 0| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X |
|__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
__________________________________________|__________________________________________________________________________|
Page 5
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 1| 1| 1| 1| | |
DAY ON TEST | 8| 7| 7| 7| 7| 7| 7| 8| 7| 7| 7| 8| 8| 8| 8| | |
| 3| 3| 3| 1| 3| 3| 1| 2| 3| 3| 3| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + | 39 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + | 39 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 39 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 40 |
Hepatocellular Carcinoma | X X X | 3 |
Hepatocellular Carcinoma, Multiple | | 1 |
Hepatocellular Adenoma | X X | 4 |
|__________________________________________________________________________|____________|
Mesentery | | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Pharynx | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 6
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 1| 1| 1| 1| | |
DAY ON TEST | 8| 7| 7| 7| 7| 7| 7| 8| 7| 7| 7| 8| 8| 8| 8| | |
| 3| 3| 3| 1| 3| 3| 1| 2| 3| 3| 3| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Tooth | + | 1 |
Odontoma | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + | 39 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + M + + M + + + + + + + + + + | 34 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + M M + + + + | 38 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 7
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 1| 1| 1| 1| | |
DAY ON TEST | 8| 7| 7| 7| 7| 7| 7| 8| 7| 7| 7| 8| 8| 8| 8| | |
| 3| 3| 3| 1| 3| 3| 1| 2| 3| 3| 3| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Penis | | 1 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + M + + + + + + | 38 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Lymph Node | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | M + + M + + M + + + + + + + + | 32 |
Lymphoma Malignant Lymphocytic | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M + + + M M + M M M + + | 24 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M M M + M M + + M + + M + M | 19 |
Lymphoma Malignant Lymphocytic | | 1 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + | 40 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 1| 1| 1| 1| | |
DAY ON TEST | 8| 7| 7| 7| 7| 7| 7| 8| 7| 7| 7| 8| 8| 8| 8| | |
| 3| 3| 3| 1| 3| 3| 1| 2| 3| 3| 3| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 40 |
Alveolar/Bronchiolar Adenoma | | 2 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 9
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 1| 1| 1| 1| | |
DAY ON TEST | 8| 7| 7| 7| 7| 7| 7| 8| 7| 7| 7| 8| 8| 8| 8| | |
| 3| 3| 3| 1| 3| 3| 1| 2| 3| 3| 3| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
CONTROL | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + | 40 |
Adenoma | X | 2 |
|__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + | 40 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + | 40 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
_____________________________________________________________________________________________________________________
| 3| 0| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 7| 1| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 3| 6| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
70 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + |
|__________________________________________________________________________|
Gallbladder | + A |
|__________________________________________________________________________|
Intestine Large, Colon | + + |
|__________________________________________________________________________|
Intestine Large, Rectum | + + |
|__________________________________________________________________________|
Intestine Large, Cecum | + + |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + |
|__________________________________________________________________________|
Intestine Small, Jejunum | + A |
|__________________________________________________________________________|
Intestine Small, Ileum | + A |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X |
Hepatocellular Adenoma | X |
Hepatocellular Adenoma, Multiple | |
|__________________________________________________________________________|
Mesentery | + + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pharynx | + + |
|__________________________________________________________________________|
Salivary Glands | + + |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tongue | + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 11
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
_____________________________________________________________________________________________________________________
| 3| 0| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 7| 1| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 3| 6| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
70 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
|__________________________________________________________________________|
Blood Vessel | + + |
|__________________________________________________________________________|
Heart | + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + |
|__________________________________________________________________________|
Adrenal Medulla | + + |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + |
|__________________________________________________________________________|
Pituitary Gland | + + |
|__________________________________________________________________________|
Thyroid Gland | + + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + |
|__________________________________________________________________________|
Preputial Gland | + + |
|__________________________________________________________________________|
Prostate | + + |
|__________________________________________________________________________|
Seminal Vesicle | + + |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 12
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
_____________________________________________________________________________________________________________________
| 3| 0| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 7| 1| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 3| 6| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
70 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Bone Marrow | + + |
|__________________________________________________________________________|
Lymph Node | + |
|__________________________________________________________________________|
Lymph Node, Bronchial | + M |
|__________________________________________________________________________|
Lymph Node, Mandibular | M + |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + |
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + |
|__________________________________________________________________________|
Spleen | + + + + + |
|__________________________________________________________________________|
Thymus | + + |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M |
|__________________________________________________________________________|
Skin | + + + + |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + |
|__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + |
|__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
_____________________________________________________________________________________________________________________
| 3| 0| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 7| 1| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 3| 6| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
70 PPM | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X X|
|__________________________________________________________________________|
Zymbal's Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + |
|__________________________________________________________________________|
Urinary Bladder | + + + + |
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 14
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
70 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 12 |
|__________________________________________________________________________|____________|
Gallbladder | + M + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 12 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 12 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 12 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 12 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 11 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 11 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 40 |
Hepatocellular Carcinoma | | 1 |
Hepatocellular Adenoma | X X | 3 |
Hepatocellular Adenoma, Multiple | X | 1 |
|__________________________________________________________________________|____________|
Mesentery | | 2 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Pharynx | + + + + + + + + + + | 12 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 12 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 15
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
70 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 12 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 12 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 12 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + M + + + + + + + + | 11 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 12 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 12 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 16
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
70 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
Prostate | + + + + + + + + + + | 12 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 12 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 12 |
|__________________________________________________________________________|____________|
Lymph Node | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + | 11 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + M M + + + M M | 7 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M + + + + + + M + | 10 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 15 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 14 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 17
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
70 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Bone | + + + + + + + + + + | 12 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 12 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 12 |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 40 |
Alveolar/Bronchiolar Adenoma | X | 2 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + | 12 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + | 40 |
Adenoma | X X | 6 |
|__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 18
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
70 PPM | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + | 15 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + | 40 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 19
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
220 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | A |
|__________________________________________________________________________|
Gallbladder | A |
|__________________________________________________________________________|
Intestine Large, Colon | A |
|__________________________________________________________________________|
Intestine Large, Rectum | A |
|__________________________________________________________________________|
Intestine Large, Cecum | A |
|__________________________________________________________________________|
Intestine Small, Duodenum | A |
|__________________________________________________________________________|
Intestine Small, Jejunum | A |
|__________________________________________________________________________|
Intestine Small, Ileum | A |
|__________________________________________________________________________|
Liver | + + + + A + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X |
Hepatocellular Adenoma | X X X |
Hepatocellular Adenoma, Multiple | X X |
|__________________________________________________________________________|
Pancreas | + + + + A + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pharynx | + |
|__________________________________________________________________________|
Salivary Glands | A |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + A + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + A + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Tongue | + |
|__________________________________________________________________________|
Tooth | + |
Odontoma | X |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
220 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | A |
|__________________________________________________________________________|
Heart | A |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | A |
|__________________________________________________________________________|
Adrenal Medulla | A |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + A + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | A |
|__________________________________________________________________________|
Pituitary Gland | A |
|__________________________________________________________________________|
Thyroid Gland | A |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | A |
|__________________________________________________________________________|
Preputial Gland | A |
|__________________________________________________________________________|
Prostate | A |
|__________________________________________________________________________|
Seminal Vesicle | A |
|__________________________________________________________________________|
Testes | + + + + A + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | A |
__________________________________________|__________________________________________________________________________|
Page 21
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
220 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
|__________________________________________________________________________|
Lymph Node, Bronchial | A |
|__________________________________________________________________________|
Lymph Node, Mandibular | A |
|__________________________________________________________________________|
Lymph Node, Mesenteric | A |
|__________________________________________________________________________|
Lymph Node, Mediastinal | A |
|__________________________________________________________________________|
Spleen | A |
|__________________________________________________________________________|
Thymus | A |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | A |
|__________________________________________________________________________|
Skin | A |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | A + |
|__________________________________________________________________________|
Skeletal Muscle | + + + + A + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | A |
|__________________________________________________________________________|
Peripheral Nerve | + + + + A + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord | + + + + A + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | A |
__________________________________________|__________________________________________________________________________|
Page 22
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|
220 PPM | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
|__________________________________________________________________________|
Lung | + + + + A + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X |
|__________________________________________________________________________|
Nose | + + + + A + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | A |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + |
|__________________________________________________________________________|
Harderian Gland | + + + + A + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X X|
|__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | A |
|__________________________________________________________________________|
Urinary Bladder | A |
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 23
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 0| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
| 9| 2| 2| 2| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
220 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + | 11 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + M + + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + | 11 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + | 11 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + | 11 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + M + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + | 11 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + | 11 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 39 |
Hepatocellular Carcinoma | X | 3 |
Hepatocellular Adenoma | | 3 |
Hepatocellular Adenoma, Multiple | X | 3 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + | 39 |
|__________________________________________________________________________|____________|
Pharynx | + + + + + + + + + + + | 12 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + | 11 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 39 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + | 39 |
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 24
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 0| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
| 9| 2| 2| 2| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
220 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Tooth | + | 2 |
Odontoma | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | M + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + | 11 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + | 11 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + | 39 |
|__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + M + M + | 8 |
|__________________________________________________________________________|____________|
Pituitary Gland | + M + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + | 11 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + | 11 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 25
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 0| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
| 9| 2| 2| 2| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
220 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + | 11 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + | 11 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 39 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + | 11 |
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + M + + | 10 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + M M + | 9 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M + M + + + M M + + | 7 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + | 11 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 26
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 0| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
| 9| 2| 2| 2| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
220 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + | 39 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + | 11 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + | 39 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + | 39 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + | 11 |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 39 |
Alveolar/Bronchiolar Adenoma | | 1 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + | 39 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + | 11 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + | 12 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + | 39 |
Adenoma | | 4 |
|__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + | 12 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 27
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 0| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | |
| 9| 2| 2| 2| 2| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
220 PPM | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + | 11 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + | 11 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + | 40 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 28
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7|
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
700 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + |
|__________________________________________________________________________|
Gallbladder | + A |
|__________________________________________________________________________|
Intestine Large, Colon | + + |
|__________________________________________________________________________|
Intestine Large, Rectum | + + |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + |
|__________________________________________________________________________|
Intestine Small, Duodenum | A + |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + |
|__________________________________________________________________________|
Intestine Small, Ileum | + + |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X X X |
Hepatocellular Carcinoma, Multiple | X |
Hepatocellular Adenoma | X X X X X X X X |
Hepatocellular Adenoma, Multiple | X X X |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
|__________________________________________________________________________|
Mesentery | + + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pharynx | + + |
|__________________________________________________________________________|
Salivary Glands | + + |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Papilloma | X |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 29
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7|
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
700 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
|__________________________________________________________________________|
Tongue | + + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + |
|__________________________________________________________________________|
Heart | + + |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + |
|__________________________________________________________________________|
Adrenal Medulla | + + |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + |
|__________________________________________________________________________|
Pituitary Gland | + + |
|__________________________________________________________________________|
Thyroid Gland | + + |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + |
|__________________________________________________________________________|
Preputial Gland | + + + + + |
|__________________________________________________________________________|
Prostate | + + |
|__________________________________________________________________________|
Seminal Vesicle | + + |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 30
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7|
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
700 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + |
Lymphoma Malignant Lymphocytic | |
|__________________________________________________________________________|
Lymph Node, Bronchial | + M |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + M + |
Lymphoma Malignant Lymphocytic | |
|__________________________________________________________________________|
Lymph Node, Mediastinal | + + |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
|__________________________________________________________________________|
Spleen | + + |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
|__________________________________________________________________________|
Thymus | + + |
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M |
|__________________________________________________________________________|
Skin | + + |
Squamous Cell Papilloma | |
Sebaceous Gland, Adenoma | |
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7|
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
700 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + |
|__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + |
|__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + M + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X |
Alveolar/Bronchiolar Carcinoma | X |
Lymphoma Malignant Histiocytic | X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + + |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X X X X X X X X |
Adenoma, Multiple | X |
|__________________________________________________________________________|
Zymbal's Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 32
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
_____________________________________________________________________________________________________________________
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
DAY ON TEST | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 2| 7|
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
700 PPM | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
|__________________________________________________________________________|
Kidney | + + + |
Bilateral, Lymphoma Malignant | |
Lymphocytic | |
|__________________________________________________________________________|
Urinary Bladder | + + |
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | |
__________________________________________|__________________________________________________________________________|
Page 33
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 7| 8| 8| | |
| 2| 2| 2| 2| 5| 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
700 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + | 12 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + | 14 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + | 12 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 40 |
Hepatocellular Carcinoma | | 4 |
Hepatocellular Carcinoma, Multiple | | 1 |
Hepatocellular Adenoma | X X X X | 12 |
Hepatocellular Adenoma, Multiple | | 3 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
|__________________________________________________________________________|____________|
Mesentery | | 2 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Pharynx | + + + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 34
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 7| 8| 8| | |
| 2| 2| 2| 2| 5| 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
700 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Stomach, Forestomach | + + + + + + + + + + + + + + + | 40 |
Squamous Cell Papilloma | X | 2 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + | 13 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + | 13 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Parathyroid Gland | M M + + + + + + + + + | 11 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + | 13 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 35
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 7| 8| 8| | |
| 2| 2| 2| 2| 5| 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
700 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
Epididymis | + + + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + | 16 |
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + | 13 |
Lymphoma Malignant Lymphocytic | X | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + M + | 11 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + M + M + + | 11 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + | 13 |
Lymphoma Malignant Lymphocytic | X | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + M + + M + + + M + | 9 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + | 13 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 36
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 7| 8| 8| | |
| 2| 2| 2| 2| 5| 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
700 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Thymus | + + + + + + + + + + + | 13 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + | 14 |
Squamous Cell Papilloma | X | 1 |
Sebaceous Gland, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + | 39 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 40 |
Alveolar/Bronchiolar Adenoma | | 4 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 37
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
__________________________________________________________________________________________________________________________________
| 3| 3| 3| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 7| 8| 8| | |
| 2| 2| 2| 2| 5| 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
700 PPM | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar/Bronchiolar Carcinoma | | 1 |
Lymphoma Malignant Histiocytic | | 1 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + | 13 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + | 13 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + | 40 |
Adenoma | X X X | 13 |
Adenoma, Multiple | | 1 |
|__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + | 13 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + | 14 |
Bilateral, Lymphoma Malignant | | |
Lymphocytic | X | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + | 13 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + | 40 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 38
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
_____________________________________________________________________________________________________________________
| 3| 3| 1| 1| 1| 1| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3| 1| 2| 1| 1| 3|
DAY ON TEST | 7| 7| 6| 8| 3| 8| 7| 7| 7| 7| 8| 7| 7| 7| 7| 7| 7| 8| 2| 7| 8| 8| 8| 8| 7|
| 1| 1| 0| 5| 6| 5| 1| 1| 1| 1| 5| 1| 1| 1| 1| 1| 1| 5| 6| 1| 5| 9| 5| 5| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2200 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + M + + + + +|
|__________________________________________________________________________|
Gallbladder | + + A + + + + + + + + + + + + + + + A + + A + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + M + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + A + + + + + + + + + + + + + + + + + + A + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + A + + + + + + + + + + + + + + + A + + A + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + A + + + + + + + + + + + + + + + A + + A + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A + + A + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + + + + + + + + + + A + + A + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemangioma | X |
Hepatocellular Carcinoma | X |
Hepatocellular Carcinoma, Multiple | X X |
Hepatocellular Adenoma | X X X X X X |
Hepatocellular Adenoma, Multiple | X X X X |
Lymphoma Malignant Lymphocytic | X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X |
|__________________________________________________________________________|
Mesentery | + + + |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pharynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 39
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
_____________________________________________________________________________________________________________________
| 3| 3| 1| 1| 1| 1| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3| 1| 2| 1| 1| 3|
DAY ON TEST | 7| 7| 6| 8| 3| 8| 7| 7| 7| 7| 8| 7| 7| 7| 7| 7| 7| 8| 2| 7| 8| 8| 8| 8| 7|
| 1| 1| 0| 5| 6| 5| 1| 1| 1| 1| 5| 1| 1| 1| 1| 1| 1| 5| 6| 1| 5| 9| 5| 5| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2200 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma | X |
Squamous Cell Papilloma | X|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + M + + + + + + + + + + A + + +|
|__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + M + + + + + + + + + + + + + + + + + + + + M +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + M + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Medulla | + + + M + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + M M M + + + + + + + + + + + + + + M + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + M M + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + A + + +|
__________________________________________|__________________________________________________________________________|
Page 40
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
_____________________________________________________________________________________________________________________
| 3| 3| 1| 1| 1| 1| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3| 1| 2| 1| 1| 3|
DAY ON TEST | 7| 7| 6| 8| 3| 8| 7| 7| 7| 7| 8| 7| 7| 7| 7| 7| 7| 8| 2| 7| 8| 8| 8| 8| 7|
| 1| 1| 0| 5| 6| 5| 1| 1| 1| 1| 5| 1| 1| 1| 1| 1| 1| 5| 6| 1| 5| 9| 5| 5| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2200 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
|__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + M + + + + + M + + + + + M + +|
Lymphoma Malignant Lymphocytic | X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + M + + + M M + M + + +|
Lymphoma Malignant Lymphocytic | X |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + M + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X |
|__________________________________________________________________________|
Lymph Node, Mediastinal | M M + M M + + M M M + M + + + M + + + M M + + M M|
Lymphoma Malignant Lymphocytic | X |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
|__________________________________________________________________________|
Thymus | + + + M + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
Page 41
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
_____________________________________________________________________________________________________________________
| 3| 3| 1| 1| 1| 1| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3| 1| 2| 1| 1| 3|
DAY ON TEST | 7| 7| 6| 8| 3| 8| 7| 7| 7| 7| 8| 7| 7| 7| 7| 7| 7| 8| 2| 7| 8| 8| 8| 8| 7|
| 1| 1| 0| 5| 6| 5| 1| 1| 1| 1| 5| 1| 1| 1| 1| 1| 1| 5| 6| 1| 5| 9| 5| 5| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2200 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + + + + + + + + + + + + + + + + + + M + + A + + +|
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + A + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + A + + + + + + + + + + + + + + + + M + + + + +|
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | |
Alveolar/Bronchiolar Carcinoma, | |
Multiple | |
Squamous Cell Carcinoma, Metastatic, | |
Stomach, Forestomach | X |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Turbinate, Olfactory Epithelium, | |
Lymphoma Malignant | X |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 42
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
_____________________________________________________________________________________________________________________
| 3| 3| 1| 1| 1| 1| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 1| 3| 3| 1| 2| 1| 1| 3|
DAY ON TEST | 7| 7| 6| 8| 3| 8| 7| 7| 7| 7| 8| 7| 7| 7| 7| 7| 7| 8| 2| 7| 8| 8| 8| 8| 7|
| 1| 1| 0| 5| 6| 5| 1| 1| 1| 1| 5| 1| 1| 1| 1| 1| 1| 5| 6| 1| 5| 9| 5| 5| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
2200 PPM | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X X X X X|
Adenoma, Multiple | X |
Carcinoma | |
Lymphoma Malignant | X |
|__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Lymphoma Malignant | |
Lymphocytic | X |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant | X |
Lymphoma Malignant Lymphocytic | X |
__________________________________________|__________________________________________________________________________|
Page 43
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| | |
DAY ON TEST | 8| 7| 7| 7| 7| 7| 7| 7| 7| 8| 7| 7| 7| 7| 8| | |
| 5| 1| 1| 1| 1| 1| 1| 1| 1| 5| 1| 1| 1| 1| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
2200 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + | 39 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + | 37 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + | 39 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + | 38 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + | 37 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 37 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 38 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + | 37 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 40 |
Hemangioma | X | 2 |
Hepatocellular Carcinoma | | 1 |
Hepatocellular Carcinoma, Multiple | X | 3 |
Hepatocellular Adenoma | X X X X X X X | 13 |
Hepatocellular Adenoma, Multiple | X | 5 |
Lymphoma Malignant Lymphocytic | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | | 1 |
|__________________________________________________________________________|____________|
Mesentery | + | 4 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 44
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| | |
DAY ON TEST | 8| 7| 7| 7| 7| 7| 7| 7| 7| 8| 7| 7| 7| 7| 8| | |
| 5| 1| 1| 1| 1| 1| 1| 1| 1| 5| 1| 1| 1| 1| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
2200 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Pharynx | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 40 |
Squamous Cell Carcinoma | X | 2 |
Squamous Cell Papilloma | X | 2 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + | 38 |
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + | 38 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + | 39 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + | 39 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Parathyroid Gland | M + + + M + M + + + M + + + + | 32 |
|__________________________________________________________________________|____________|
Pituitary Gland | M + + + + + + + + + + + + + + | 37 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 39 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 45
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| | |
DAY ON TEST | 8| 7| 7| 7| 7| 7| 7| 7| 7| 8| 7| 7| 7| 7| 8| | |
| 5| 1| 1| 1| 1| 1| 1| 1| 1| 5| 1| 1| 1| 1| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
2200 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + | 39 |
|__________________________________________________________________________|____________|
Prostate | + + + + M + + + + + + + + + + | 39 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + | 40 |
Lymphoma Malignant Lymphocytic | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + M M + + + + + + + | 35 |
Lymphoma Malignant Lymphocytic | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + M + + + M | 33 |
Lymphoma Malignant Lymphocytic | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 39 |
Lymphoma Malignant Lymphocytic | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M M M M M M + + + + + + + M | 20 |
Lymphoma Malignant Lymphocytic | | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 46
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| | |
DAY ON TEST | 8| 7| 7| 7| 7| 7| 7| 7| 7| 8| 7| 7| 7| 7| 8| | |
| 5| 1| 1| 1| 1| 1| 1| 1| 1| 5| 1| 1| 1| 1| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
2200 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 40 |
Lymphoma Malignant Lymphocytic | | 1 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + | 39 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + + + + + + + | 38 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + | 39 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + | 38 |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 47
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| | |
DAY ON TEST | 8| 7| 7| 7| 7| 7| 7| 7| 7| 8| 7| 7| 7| 7| 8| | |
| 5| 1| 1| 1| 1| 1| 1| 1| 1| 5| 1| 1| 1| 1| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
2200 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolar/Bronchiolar Adenoma | X X X X | 8 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | X X | 2 |
Alveolar/Bronchiolar Carcinoma, | | |
Multiple | X | 1 |
Squamous Cell Carcinoma, Metastatic, | | |
Stomach, Forestomach | | 1 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + | 40 |
Turbinate, Olfactory Epithelium, | | |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + | 40 |
Adenoma | X X X X | 11 |
Adenoma, Multiple | X | 2 |
Carcinoma | X | 1 |
Lymphoma Malignant | | 1 |
|__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 40 |
Bilateral, Lymphoma Malignant | | |
Lymphocytic | | 1 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 48
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3| 1| | |
DAY ON TEST | 8| 7| 7| 7| 7| 7| 7| 7| 7| 8| 7| 7| 7| 7| 8| | |
| 5| 1| 1| 1| 1| 1| 1| 1| 1| 5| 1| 1| 1| 1| 5| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A |
2200 PPM | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
| | |
Urinary Bladder | + + + + + + + + + + + + + + + | 40 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + | 40 |
Lymphoma Malignant | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 49
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
_____________________________________________________________________________________________________________________
| 3| 1| 3| 1| 1| 1| 1| 1| 3| 1| 1| 1| 3| 3| 1| 3| 2| 3| 3| 3| 3| 3| 1| 1| 3|
DAY ON TEST | 7| 2| 7| 8| 8| 2| 2| 8| 1| 4| 8| 8| 7| 7| 8| 7| 0| 7| 7| 7| 7| 7| 8| 8| 7|
| 1| 3| 1| 5| 5| 8| 3| 3| 7| 6| 5| 3| 1| 1| 5| 1| 9| 1| 1| 1| 1| 1| 3| 5| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
7000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + A + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + A + + + + A + + + + + M + M M + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + A + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + A + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + A + + + + A + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + A + + + + A + + + + + M + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + A + + + + A + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + A + + + + A + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + A + + + + + + + + + + + + + + + + + + + + + + +|
Hepatocellular Carcinoma | X X X X |
Hepatocellular Adenoma | X X |
Hepatocellular Adenoma, Multiple | X X X X X X|
Lymphoma Malignant Lymphocytic | X |
|__________________________________________________________________________|
Mesentery | + |
|__________________________________________________________________________|
Pancreas | + A + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pharynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Salivary Glands | + A + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + A + + + + + + + + + + + + + + + + + + + + + + +|
Squamous Cell Carcinoma | X |
Squamous Cell Papilloma | X X |
Squamous Cell Papilloma, Multiple | |
|__________________________________________________________________________|
Stomach, Glandular | + A + + + + A + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 50
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
_____________________________________________________________________________________________________________________
| 3| 1| 3| 1| 1| 1| 1| 1| 3| 1| 1| 1| 3| 3| 1| 3| 2| 3| 3| 3| 3| 3| 1| 1| 3|
DAY ON TEST | 7| 2| 7| 8| 8| 2| 2| 8| 1| 4| 8| 8| 7| 7| 8| 7| 0| 7| 7| 7| 7| 7| 8| 8| 7|
| 1| 3| 1| 5| 5| 8| 3| 3| 7| 6| 5| 3| 1| 1| 5| 1| 9| 1| 1| 1| 1| 1| 3| 5| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
7000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
| |
|__________________________________________________________________________|
Tongue | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + A + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + A + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + A + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Medulla | + A + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + A + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + M + M + + + + + + + + + M + + M + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + A + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Thyroid Gland | + A + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Penis | + + |
|__________________________________________________________________________|
Preputial Gland | + A + + + + + + + + + + + + + + + + + + + + + + M|
|__________________________________________________________________________|
Prostate | + M + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________|__________________________________________________________________________|
Page 51
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
_____________________________________________________________________________________________________________________
| 3| 1| 3| 1| 1| 1| 1| 1| 3| 1| 1| 1| 3| 3| 1| 3| 2| 3| 3| 3| 3| 3| 1| 1| 3|
DAY ON TEST | 7| 2| 7| 8| 8| 2| 2| 8| 1| 4| 8| 8| 7| 7| 8| 7| 0| 7| 7| 7| 7| 7| 8| 8| 7|
| 1| 3| 1| 5| 5| 8| 3| 3| 7| 6| 5| 3| 1| 1| 5| 1| 9| 1| 1| 1| 1| 1| 3| 5| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
7000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
| |
|__________________________________________________________________________|
Seminal Vesicle | + A + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + A + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Bronchial | + M M + + M + + + + + + + + + + + + + M + + + M +|
Lymphoma Malignant Lymphocytic | X |
|__________________________________________________________________________|
Lymph Node, Mandibular | + M + + + M + + + M + + + M + + + M M + + M M + M|
Lymphoma Malignant Lymphocytic | X |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + A + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
|__________________________________________________________________________|
Lymph Node, Mediastinal | M M M M M M + M + M + + M + M + + + + + + M + M +|
Lymphoma Malignant Lymphocytic | X |
|__________________________________________________________________________|
Spleen | + A + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
|__________________________________________________________________________|
Thymus | + M + + + M + + + M + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Subcutaneous Tissue, Sarcoma | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 52
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
_____________________________________________________________________________________________________________________
| 3| 1| 3| 1| 1| 1| 1| 1| 3| 1| 1| 1| 3| 3| 1| 3| 2| 3| 3| 3| 3| 3| 1| 1| 3|
DAY ON TEST | 7| 2| 7| 8| 8| 2| 2| 8| 1| 4| 8| 8| 7| 7| 8| 7| 0| 7| 7| 7| 7| 7| 8| 8| 7|
| 1| 3| 1| 5| 5| 8| 3| 3| 7| 6| 5| 3| 1| 1| 5| 1| 9| 1| 1| 1| 1| 1| 3| 5| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
7000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
| |
|__________________________________________________________________________|
Bone | + A + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + A + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Lymphocytic | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + A + + + + + + + + + + + + + + + + + + + + + + +|
Meningioma Malignant, Metastatic, | |
Spinal Cord | X |
|__________________________________________________________________________|
Peripheral Nerve | + A + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Spinal Cord | + A + + + + + + + + + + + + + + + + + + + + + + +|
Meningioma Malignant | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + A + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lung | + A + + + + + + + + + + + + + + + + + + + + + + +|
Alveolar/Bronchiolar Adenoma | X X X X |
Alveolar/Bronchiolar Adenoma, | |
Multiple | X X|
Alveolar/Bronchiolar Carcinoma | |
Lymphoma Malignant Lymphocytic | X |
|__________________________________________________________________________|
Nose | + A + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Trachea | + A + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 53
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
_____________________________________________________________________________________________________________________
| 3| 1| 3| 1| 1| 1| 1| 1| 3| 1| 1| 1| 3| 3| 1| 3| 2| 3| 3| 3| 3| 3| 1| 1| 3|
DAY ON TEST | 7| 2| 7| 8| 8| 2| 2| 8| 1| 4| 8| 8| 7| 7| 8| 7| 0| 7| 7| 7| 7| 7| 8| 8| 7|
| 1| 3| 1| 5| 5| 8| 3| 3| 7| 6| 5| 3| 1| 1| 5| 1| 9| 1| 1| 1| 1| 1| 3| 5| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
7000 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
Harderian Gland | + A + + + + + + + + + + + + + + + + + + + + + + +|
Adenoma | X X X |
Adenoma, Multiple | X X |
|__________________________________________________________________________|
Zymbal's Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + A + + + + + + + + + + + + + + + + + + + + + + +|
Bilateral, Lymphoma Malignant | |
Lymphocytic | X |
|__________________________________________________________________________|
Urinary Bladder | + A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
SYSTEMIC LESIONS | |
__________________________________________________________________________|
Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoma Malignant Histiocytic | X |
Lymphoma Malignant Lymphocytic | X |
__________________________________________|__________________________________________________________________________|
Page 54
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 3| 1| 1| 3| 1| 3| 3| 3| 3| 3| | |
DAY ON TEST | 8| 7| 7| 7| 7| 7| 8| 2| 7| 2| 7| 7| 7| 7| 1| | |
| 3| 1| 1| 1| 1| 1| 3| 8| 1| 3| 1| 1| 1| 1| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
7000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + A + + + + + | 38 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + A + + + + A | 33 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + A + + + + + | 38 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + A + + + + + | 38 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + | 37 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + | 36 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + A | 36 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + A + + + + A | 36 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + A + + + + + | 38 |
Hepatocellular Carcinoma | X X X X X | 9 |
Hepatocellular Adenoma | X X X | 5 |
Hepatocellular Adenoma, Multiple | X X X X X | 11 |
Lymphoma Malignant Lymphocytic | | 1 |
|__________________________________________________________________________|____________|
Mesentery | + | 2 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + A + + + + + | 38 |
|__________________________________________________________________________|____________|
Pharynx | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + A + + + + + | 38 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + A + + + + + | 38 |
Squamous Cell Carcinoma | | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 55
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 3| 1| 1| 3| 1| 3| 3| 3| 3| 3| | |
DAY ON TEST | 8| 7| 7| 7| 7| 7| 8| 2| 7| 2| 7| 7| 7| 7| 1| | |
| 3| 1| 1| 1| 1| 1| 3| 8| 1| 3| 1| 1| 1| 1| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
7000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
| | |
Squamous Cell Papilloma | X X | 4 |
Squamous Cell Papilloma, Multiple | X | 1 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + A + + + + + | 37 |
|__________________________________________________________________________|____________|
Tongue | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + A + + + + + | 38 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + A + + + + + | 38 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + A + + + + + | 38 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + A + + + + + | 38 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + A + + + + + | 38 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + M + + + + M | 34 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + M + + + A + + M + M | 35 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + A + + + + + | 38 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 56
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 3| 1| 1| 3| 1| 3| 3| 3| 3| 3| | |
DAY ON TEST | 8| 7| 7| 7| 7| 7| 8| 2| 7| 2| 7| 7| 7| 7| 1| | |
| 3| 1| 1| 1| 1| 1| 3| 8| 1| 3| 1| 1| 1| 1| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
7000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + A + + + + + | 39 |
|__________________________________________________________________________|____________|
Penis | A | 2 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + A + + + + + | 37 |
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + M + + + + + | 37 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + A + + + + + | 38 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + A + + + + + | 39 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + A + + + + + | 38 |
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + + + + + + + M M + + + + | 32 |
Lymphoma Malignant Lymphocytic | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M + M + + + + A M + M + M | 23 |
Lymphoma Malignant Lymphocytic | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + A + + + M + | 37 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + M + M + + M A + M M + + | 22 |
Lymphoma Malignant Lymphocytic | | 1 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + A + + + + + | 38 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 57
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 3| 1| 1| 3| 1| 3| 3| 3| 3| 3| | |
DAY ON TEST | 8| 7| 7| 7| 7| 7| 8| 2| 7| 2| 7| 7| 7| 7| 1| | |
| 3| 1| 1| 1| 1| 1| 3| 8| 1| 3| 1| 1| 1| 1| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
7000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + A + + + + + | 36 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M M M M M M | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + A + + + + + | 39 |
Subcutaneous Tissue, Sarcoma | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + | 39 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + A + + + + + | 38 |
Lymphoma Malignant Lymphocytic | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + A + + + + + | 38 |
Meningioma Malignant, Metastatic, | | |
Spinal Cord | | 1 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + + + + + + + A + + + + + | 38 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + A + + + + + | 38 |
Meningioma Malignant | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + A + + + + + | 38 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 58
NTP Experiment-Test: 05135-06 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04
Study Type: SIX MONTH EXPOS. ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:28:03
__________________________________________________________________________________________________________________________________
| 1| 3| 3| 3| 3| 3| 1| 1| 3| 1| 3| 3| 3| 3| 3| | |
DAY ON TEST | 8| 7| 7| 7| 7| 7| 8| 2| 7| 2| 7| 7| 7| 7| 1| | |
| 3| 1| 1| 1| 1| 1| 3| 8| 1| 3| 1| 1| 1| 1| 7| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
7000 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + A + + + + + | 38 |
Alveolar/Bronchiolar Adenoma | X | 5 |
Alveolar/Bronchiolar Adenoma, | | |
Multiple | X X | 4 |
Alveolar/Bronchiolar Carcinoma | X X X | 3 |
Lymphoma Malignant Lymphocytic | | 1 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + A + + + + + | 38 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + A + + + + + | 38 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + A + + + + + | 38 |
Adenoma | X X X X | 7 |
Adenoma, Multiple | X X X | 5 |
|__________________________________________________________________________|____________|
Zymbal's Gland | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + A + + + + + | 38 |
Bilateral, Lymphoma Malignant | | |
Lymphocytic | | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + A + + + + + | 38 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + + + + + + | 40 |
Lymphoma Malignant Histiocytic | | 1 |
Lymphoma Malignant Lymphocytic | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 59
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