TDMS Study 61938-01 Pathology Tables
NTP Experiment-Test: 61938-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 1-NITROPYRENE Date: 10/18/04
Route: RESPIRATORY EXPOSURE NASAL Time: 08:36:22
Facility: Battelle Northwest
Chemical CAS #: 5522-43-0
Lock Date: 06/05/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 61938-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 1-NITROPYRENE Date: 10/18/04
Route: RESPIRATORY EXPOSURE NASAL Time: 08:36:22
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Necrosis, Focal | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
Cardiomyopathy | 1 1 1 1 | 4 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 2
NTP Experiment-Test: 61938-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 1-NITROPYRENE Date: 10/18/04
Route: RESPIRATORY EXPOSURE NASAL Time: 08:36:22
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 10 |
Cyst | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + M + + + | 9 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + M + + + + | 9 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + M + + + + | 9 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 3
NTP Experiment-Test: 61938-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 1-NITROPYRENE Date: 10/18/04
Route: RESPIRATORY EXPOSURE NASAL Time: 08:36:22
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
Inflammation, Chronic Active | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Hemorrhage | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
Alveolar Epithelium, Hyperplasia | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
Olfactory Epithelium, Cytoplasmic | | |
Alteration | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 4
NTP Experiment-Test: 61938-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 1-NITROPYRENE Date: 10/18/04
Route: RESPIRATORY EXPOSURE NASAL Time: 08:36:22
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Nephropathy | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 5
NTP Experiment-Test: 61938-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 1-NITROPYRENE Date: 10/18/04
Route: RESPIRATORY EXPOSURE NASAL Time: 08:36:22
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.5 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + | 3 |
Hepatodiaphragmatic Nodule | X X | 2 |
Inflammation, Chronic | 3 | 1 3.0|
Necrosis, Focal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + | 1 |
Hemorrhage | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 61938-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 1-NITROPYRENE Date: 10/18/04
Route: RESPIRATORY EXPOSURE NASAL Time: 08:36:22
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.5 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Larynx | + + + + + + + + + + | 10 |
Epiglottis, Metaplasia, Squamous | 1 1 1 1 | 4 1.0|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Hemorrhage | 1 1 1 1 1 1 1 1 | 8 1.0|
Inflammation, Chronic Active | 1 1 1 1 1 | 5 1.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
Olfactory Epithelium, Cytoplasmic | | |
Alteration | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 61938-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 1-NITROPYRENE Date: 10/18/04
Route: RESPIRATORY EXPOSURE NASAL Time: 08:36:22
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
2.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + | 1 |
Hepatodiaphragmatic Nodule | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Spleen | + | 1 |
Fibrosis | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 10 |
Epiglottis, Metaplasia, Squamous | 1 1 1 1 | 4 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 61938-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 1-NITROPYRENE Date: 10/18/04
Route: RESPIRATORY EXPOSURE NASAL Time: 08:36:22
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | A |
2.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Hemorrhage | 1 1 1 1 1 1 | 6 1.0|
Inflammation, Chronic Active | 1 1 | 2 1.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
Olfactory Epithelium, Cytoplasmic | | |
Alteration | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 61938-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 1-NITROPYRENE Date: 10/18/04
Route: RESPIRATORY EXPOSURE NASAL Time: 08:36:22
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
8.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + | 4 |
Hepatodiaphragmatic Nodule | X X X X | 4 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Ovary | + | 1 |
Cyst | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 10 |
Epiglottis, Metaplasia, Squamous | 3 2 1 1 3 1 1 2 2 1 | 10 1.7|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 61938-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 1-NITROPYRENE Date: 10/18/04
Route: RESPIRATORY EXPOSURE NASAL Time: 08:36:22
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | A |
8.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Hemorrhage | 1 1 1 1 1 1 1 1 1 | 9 1.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
Olfactory Epithelium, Cytoplasmic | | |
Alteration | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
Respiratory Epithelium, Cytoplasmic | | |
Alteration | 1 1 1 1 1 2 | 6 1.2|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 61938-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 1-NITROPYRENE Date: 10/18/04
Route: RESPIRATORY EXPOSURE NASAL Time: 08:36:22
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
20.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + | 1 |
Hepatodiaphragmatic Nodule | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 10 |
Epiglottis, Metaplasia, Squamous | 3 1 2 2 2 3 1 2 2 2 | 10 2.0|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 61938-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 1-NITROPYRENE Date: 10/18/04
Route: RESPIRATORY EXPOSURE NASAL Time: 08:36:22
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | A |
20.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Hemorrhage | 1 1 1 1 1 1 1 | 7 1.0|
Inflammation, Chronic Active | 1 3 | 2 2.0|
Bronchus, Metaplasia, Squamous | 1 1 | 2 1.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
Olfactory Epithelium, Cytoplasmic | | |
Alteration | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
Respiratory Epithelium, Cytoplasmic | | |
Alteration | 2 3 3 2 3 3 2 1 1 2 | 10 2.2|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 61938-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 1-NITROPYRENE Date: 10/18/04
Route: RESPIRATORY EXPOSURE NASAL Time: 08:36:22
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
50.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Hepatodiaphragmatic Nodule | X | 1 |
Inflammation, Chronic Active | 3 | 1 3.0|
Necrosis | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
Cardiomyopathy | 1 1 1 1 | 4 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 61938-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 1-NITROPYRENE Date: 10/18/04
Route: RESPIRATORY EXPOSURE NASAL Time: 08:36:22
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
50.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 10 |
Cyst | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + M M M + + + | 7 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 61938-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 1-NITROPYRENE Date: 10/18/04
Route: RESPIRATORY EXPOSURE NASAL Time: 08:36:22
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
50.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 10 |
Epiglottis, Metaplasia, Squamous | 3 3 3 3 3 2 2 3 3 3 | 10 2.8|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Hemorrhage | 1 1 1 1 1 1 1 1 1 | 9 1.0|
Inflammation, Chronic Active | 1 1 | 2 1.0|
Bronchus, Metaplasia, Squamous | 1 1 1 | 3 1.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 61938-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 1-NITROPYRENE Date: 10/18/04
Route: RESPIRATORY EXPOSURE NASAL Time: 08:36:22
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
50.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Olfactory Epithelium, Cytoplasmic | | |
Alteration | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
Respiratory Epithelium, Cytoplasmic | | |
Alteration | 3 2 2 3 3 3 3 3 2 3 | 10 2.7|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Nephropathy | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 61938-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 1-NITROPYRENE Date: 10/18/04
Route: RESPIRATORY EXPOSURE NASAL Time: 08:36:22
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Hepatodiaphragmatic Nodule | X X | 2 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
Cardiomyopathy | 1 1 1 1 1 1 | 6 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 61938-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 1-NITROPYRENE Date: 10/18/04
Route: RESPIRATORY EXPOSURE NASAL Time: 08:36:22
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | M + + + + + + + + + | 9 |
Hypospermia | 3 3 3 3 3 1 3 3 3 | 9 2.8|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
Atrophy | 1 2 2 2 1 3 1 2 3 3 | 10 2.0|
Mineralization | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Lymph Node | + | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 61938-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 1-NITROPYRENE Date: 10/18/04
Route: RESPIRATORY EXPOSURE NASAL Time: 08:36:22
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Renal, Hemorrhage | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M M M + + + M M + + | 5 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 61938-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 1-NITROPYRENE Date: 10/18/04
Route: RESPIRATORY EXPOSURE NASAL Time: 08:36:22
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
CONTROL | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Lung | + + + + + + + + + + | 10 |
Hemorrhage | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
Olfactory Epithelium, Cytoplasmic | | |
Alteration | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Nephropathy | 1 1 1 1 1 | 5 1.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 61938-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 1-NITROPYRENE Date: 10/18/04
Route: RESPIRATORY EXPOSURE NASAL Time: 08:36:22
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.5 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + | 2 |
Hepatodiaphragmatic Nodule | X X | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 10 |
Hypospermia | 3 2 2 2 1 3 3 2 1 3 | 10 2.2|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
Atrophy | 2 2 2 2 2 2 2 3 2 2 | 10 2.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 61938-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 1-NITROPYRENE Date: 10/18/04
Route: RESPIRATORY EXPOSURE NASAL Time: 08:36:22
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.5 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + | 8 |
Hemorrhage | 1 1 1 1 1 1 1 1 | 8 1.0|
Inflammation, Chronic Active | 1 2 1 | 3 1.3|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
Olfactory Epithelium, Cytoplasmic | | |
Alteration | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 61938-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 1-NITROPYRENE Date: 10/18/04
Route: RESPIRATORY EXPOSURE NASAL Time: 08:36:22
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
2.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + | 4 |
Hepatodiaphragmatic Nodule | X X X X | 4 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 10 |
Hypospermia | 3 2 2 2 2 2 3 2 4 2 | 10 2.4|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
Atrophy | 1 1 2 2 2 2 3 3 2 2 | 10 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node | + | 1 |
Renal, Hemorrhage | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + | 1 |
Hemorrhage | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Spleen | + | 1 |
|__________________________________________________________________________|____________|
Thymus | + | 1 |
Hemorrhage | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 61938-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 1-NITROPYRENE Date: 10/18/04
Route: RESPIRATORY EXPOSURE NASAL Time: 08:36:22
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
2.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 10 |
Epiglottis, Metaplasia, Squamous | 1 1 1 1 1 | 5 1.0|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Hemorrhage | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
Inflammation, Chronic Active | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
Olfactory Epithelium, Cytoplasmic | | |
Alteration | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 61938-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 1-NITROPYRENE Date: 10/18/04
Route: RESPIRATORY EXPOSURE NASAL Time: 08:36:22
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
8.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + | 1 |
Hepatodiaphragmatic Nodule | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + | 9 |
Hypospermia | 2 2 2 1 2 2 3 3 2 | 9 2.1|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
Atrophy | 2 2 2 1 2 3 3 2 2 1 | 10 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 61938-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 1-NITROPYRENE Date: 10/18/04
Route: RESPIRATORY EXPOSURE NASAL Time: 08:36:22
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
8.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 10 |
Epiglottis, Metaplasia, Squamous | 1 1 2 2 1 3 2 2 2 2 | 10 1.8|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Hemorrhage | 1 1 1 1 1 1 1 1 1 | 9 1.0|
Inflammation, Chronic Active | 1 1 | 2 1.0|
Bronchus, Metaplasia, Squamous | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
Olfactory Epithelium, Cytoplasmic | | |
Alteration | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
Respiratory Epithelium, Cytoplasmic | | |
Alteration | 2 2 1 1 1 2 1 1 | 8 1.4|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 61938-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 1-NITROPYRENE Date: 10/18/04
Route: RESPIRATORY EXPOSURE NASAL Time: 08:36:22
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
20.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + | 1 |
Hepatodiaphragmatic Nodule | X | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 10 |
Hypospermia | 2 3 3 2 4 3 3 1 3 3 | 10 2.7|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
Atrophy | 2 3 3 2 3 3 3 1 3 2 | 10 2.5|
Mineralization | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Lymph Node | + | 1 |
Renal, Hemorrhage | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 61938-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 1-NITROPYRENE Date: 10/18/04
Route: RESPIRATORY EXPOSURE NASAL Time: 08:36:22
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | A |
20.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 10 |
Epiglottis, Metaplasia, Squamous | 2 3 3 2 2 1 2 2 2 2 | 10 2.1|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Hemorrhage | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
Inflammation, Chronic Active | 1 | 1 1.0|
Bronchus, Metaplasia, Squamous | 1 1 | 2 1.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
Olfactory Epithelium, Cytoplasmic | | |
Alteration | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
Respiratory Epithelium, Cytoplasmic | | |
Alteration | 2 2 2 2 2 3 3 2 2 1 | 10 2.1|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 61938-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 1-NITROPYRENE Date: 10/18/04
Route: RESPIRATORY EXPOSURE NASAL Time: 08:36:22
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
50.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Hepatodiaphragmatic Nodule | X | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
Cardiomyopathy | 1 1 1 1 | 4 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 61938-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 1-NITROPYRENE Date: 10/18/04
Route: RESPIRATORY EXPOSURE NASAL Time: 08:36:22
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
50.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 10 |
Hypospermia | 3 3 1 3 3 1 1 2 3 3 | 10 2.3|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
Atrophy | 2 3 1 2 3 1 2 2 3 3 | 10 2.2|
Mineralization | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + M + M + + | 8 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 61938-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 1-NITROPYRENE Date: 10/18/04
Route: RESPIRATORY EXPOSURE NASAL Time: 08:36:22
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
50.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + M + + M + + + + | 8 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M + + + + + + M + + | 8 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 10 |
Epiglottis, Metaplasia, Squamous | 3 3 3 2 1 3 2 2 3 3 | 10 2.5|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Hemorrhage | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 61938-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY 1-NITROPYRENE Date: 10/18/04
Route: RESPIRATORY EXPOSURE NASAL Time: 08:36:22
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
50.0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| | L |
MG/M3 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Bronchus, Metaplasia, Squamous | 1 1 1 1 1 | 5 1.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
Olfactory Epithelium, Cytoplasmic | | |
Alteration | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
Respiratory Epithelium, Cytoplasmic | | |
Alteration | 2 2 3 3 3 3 3 3 3 3 | 10 2.8|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Nephropathy | 1 1 1 1 1 | 5 1.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
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