TDMS Study 99022-02 Pathology Tables
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
FINAL #2; REVISION #1 MICE
Facility: Southern Research Institute
Chemical CAS #: 30516-87-1
Lock Date: 06/20/02
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Merge 006 006,016
Merge 007 007,017
Merge 008 008,018
Merge 009 009,019
Merge 010 010,020
Merge 001 001,011
Merge 002 002,012
Merge 003 003,013
Merge 004 004,014
Merge 005 005,015
Page 1
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 6| 6| 6| 1| 2| 6| 6| 5| 5| 6| 4| 5| 6| 5| 6| 6| 3| 4| 2| 6| 5| 5| 5| 6| 6|
DAY ON TEST | 5| 7| 7| 7| 4| 7| 4| 8| 9| 7| 4| 9| 7| 7| 7| 7| 5| 9| 5| 7| 9| 3| 7| 5| 7|
| 1| 4| 9| 9| 8| 5| 8| 1| 8| 6| 3| 8| 5| 3| 8| 5| 2| 7| 5| 5| 3| 5| 7| 8| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5|
0 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
MG/KG/DY | 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 0| 1|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + M + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + A + + + + A + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + I + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + M + +|
Amyloid Deposition | |
Edema | 2 |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Erosion | |
Epithelium, Hyperplasia | 2 3 2 3 2 2 |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + A + M +|
Amyloid Deposition | |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Angiectasis | |
Cyst | X |
Eosinophilic Focus | |
Hematopoietic Cell Proliferation | 3 4 2 2 4 |
Infiltration Cellular, Mixed Cell | 2 2 3 |
Necrosis, Focal | 3 3 1 2 3 |
Thrombosis | |
Hepatocyte, Hypertrophy | 2 |
Kupffer Cell, Hyperplasia | 3 |
Kupffer Cell, Pigmentation | 2 2 3 |
|__________________________________________________________________________|
Mesentery | + + |
__________________________________________|__________________________________________________________________________|
Page 2
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 6| 6| 6| 1| 2| 6| 6| 5| 5| 6| 4| 5| 6| 5| 6| 6| 3| 4| 2| 6| 5| 5| 5| 6| 6|
DAY ON TEST | 5| 7| 7| 7| 4| 7| 4| 8| 9| 7| 4| 9| 7| 7| 7| 7| 5| 9| 5| 7| 9| 3| 7| 5| 7|
| 1| 4| 9| 9| 8| 5| 8| 1| 8| 6| 3| 8| 5| 3| 8| 5| 2| 7| 5| 5| 3| 5| 7| 8| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5|
0 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
MG/KG/DY | 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 0| 1|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Hemorrhage | 4 |
Thrombosis | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis, Focal | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Epithelium, Hyperplasia | 1 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Erosion | 2 |
Glands, Hyperplasia, Cystic | 3 3 2 2 2 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + |
Inflammation, Chronic | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Cardiomyopathy | 2 1 2 |
Inflammation, Chronic | 2 2 2 |
Mineralization | 3 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 3 3 3 3|
Amyloid Deposition | |
Capsule, Hyperplasia | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
__________________________________________|__________________________________________________________________________|
Page 3
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 6| 6| 6| 1| 2| 6| 6| 5| 5| 6| 4| 5| 6| 5| 6| 6| 3| 4| 2| 6| 5| 5| 5| 6| 6|
DAY ON TEST | 5| 7| 7| 7| 4| 7| 4| 8| 9| 7| 4| 9| 7| 7| 7| 7| 5| 9| 5| 7| 9| 3| 7| 5| 7|
| 1| 4| 9| 9| 8| 5| 8| 1| 8| 6| 3| 8| 5| 3| 8| 5| 2| 7| 5| 5| 3| 5| 7| 8| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5|
0 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
MG/KG/DY | 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 0| 1|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + M + M + M + + + + + + M + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia, Focal | 1 |
Pars Intermedia, Hyperplasia | 3 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Degeneration, Cystic | 3 2 3 2 1 1 3 3 2 3 2 3 |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X X |
Inflammation, Chronic | 2 3 3 3 2 4 3 2 4 2 4|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Angiectasis | |
Cyst | X X X X X X X X X X X X X X X X X X X X X X|
Hematocyst | X |
Hemorrhage | 3 |
Corpus Luteum, Hyperplasia | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Inflammation, Chronic | 3 |
Thrombosis | X |
Endometrium, Hyperplasia, Cystic | 1 1 3 3 3 2 3 2 2 2 2 3 2 2 2 2|
__________________________________________|__________________________________________________________________________|
Page 4
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 6| 6| 6| 1| 2| 6| 6| 5| 5| 6| 4| 5| 6| 5| 6| 6| 3| 4| 2| 6| 5| 5| 5| 6| 6|
DAY ON TEST | 5| 7| 7| 7| 4| 7| 4| 8| 9| 7| 4| 9| 7| 7| 7| 7| 5| 9| 5| 7| 9| 3| 7| 5| 7|
| 1| 4| 9| 9| 8| 5| 8| 1| 8| 6| 3| 8| 5| 3| 8| 5| 2| 7| 5| 5| 3| 5| 7| 8| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5|
0 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
MG/KG/DY | 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 0| 1|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
|__________________________________________________________________________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Epithelium, Hyperplasia | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 3 4 4 3 4 3 2 2 2 3 3 4 4 4 2 4 2 3 3|
|__________________________________________________________________________|
Lymph Node | + + + + + + + |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 4 |
Hyperplasia, Plasma Cell | 3 |
Iliac, Hematopoietic Cell | |
Proliferation | 4 |
Inguinal, Hyperplasia, Lymphoid | |
Inguinal, Hyperplasia, Plasma Cell | |
Lumbar, Hematopoietic Cell | |
Proliferation | 3 |
Mediastinal, Hematopoietic Cell | |
Proliferation | 3 |
Mediastinal, Hemorrhage | 4 |
Mediastinal, Hyperplasia, Lymphoid | 3 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Atrophy | 3 |
Ectasia | 4 4 |
Hematopoietic Cell Proliferation | 3 2 2 2 |
Hemorrhage | 3 4 |
Hyperplasia, Lymphoid | 3 3 4 2 4 4 3 |
Hyperplasia, Plasma Cell | 3 3 3 4 |
Infiltration Cellular, Plasma Cell | 3 3 |
Pigmentation | 2 2 2 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
__________________________________________|__________________________________________________________________________|
Page 5
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 6| 6| 6| 1| 2| 6| 6| 5| 5| 6| 4| 5| 6| 5| 6| 6| 3| 4| 2| 6| 5| 5| 5| 6| 6|
DAY ON TEST | 5| 7| 7| 7| 4| 7| 4| 8| 9| 7| 4| 9| 7| 7| 7| 7| 5| 9| 5| 7| 9| 3| 7| 5| 7|
| 1| 4| 9| 9| 8| 5| 8| 1| 8| 6| 3| 8| 5| 3| 8| 5| 2| 7| 5| 5| 3| 5| 7| 8| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5|
0 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
MG/KG/DY | 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 0| 1|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Ectasia | |
Hematopoietic Cell Proliferation | 3 2 |
Hemorrhage | 3 3 2 3 |
Hyperplasia, Lymphoid | 1 2 1 |
Pigmentation | 2 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 4 3 4 1 2 1 3 4 3 2 3 4 4 2|
Pigmentation | 3 2 3 2 3 2|
Lymphoid Follicle, Atrophy | 3 3 4 |
Lymphoid Follicle, Hyperplasia | 3 2 3 3 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + M + + + + + +|
Atrophy | 3 3 2 2 3 |
Hemorrhage | |
Hyperplasia, Lymphoid | 2 3 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 1 1 2 3 2 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 4 3 |
Inflammation, Chronic | 2 |
Ulcer | 4 3 4 4 4 4 4 |
Epidermis, Hyperplasia | 4 3 2 3 4 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 3 |
|__________________________________________________________________________|
Skeletal Muscle | + + + |
Inflammation, Chronic | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 6
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 6| 6| 6| 1| 2| 6| 6| 5| 5| 6| 4| 5| 6| 5| 6| 6| 3| 4| 2| 6| 5| 5| 5| 6| 6|
DAY ON TEST | 5| 7| 7| 7| 4| 7| 4| 8| 9| 7| 4| 9| 7| 7| 7| 7| 5| 9| 5| 7| 9| 3| 7| 5| 7|
| 1| 4| 9| 9| 8| 5| 8| 1| 8| 6| 3| 8| 5| 3| 8| 5| 2| 7| 5| 5| 3| 5| 7| 8| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5|
0 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
MG/KG/DY | 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 0| 1|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + + + + |
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 3 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Foreign Body | X X X |
Hemorrhage | 3 1 |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Histiocyte | 3 2 2 2 2 2 2 |
Infiltration Cellular, Mixed Cell | 2 3 |
Inflammation, Chronic | 2 |
Alveolar Epithelium, Hyperplasia | 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X X |
Inflammation, Chronic | 1 2 2 1 1 2 2 3 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Harderian Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Cyst | |
Hydronephrosis | 1 |
Infiltration Cellular, Mixed Cell | 2 3 2 2 2 |
Inflammation, Chronic | 4 3 |
Metaplasia, Osseous | 1 |
__________________________________________|__________________________________________________________________________|
Page 7
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 6| 6| 6| 1| 2| 6| 6| 5| 5| 6| 4| 5| 6| 5| 6| 6| 3| 4| 2| 6| 5| 5| 5| 6| 6|
DAY ON TEST | 5| 7| 7| 7| 4| 7| 4| 8| 9| 7| 4| 9| 7| 7| 7| 7| 5| 9| 5| 7| 9| 3| 7| 5| 7|
| 1| 4| 9| 9| 8| 5| 8| 1| 8| 6| 3| 8| 5| 3| 8| 5| 2| 7| 5| 5| 3| 5| 7| 8| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5|
0 | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
MG/KG/DY | 3| 4| 5| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 0| 1|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Nephropathy | 2 4 1 2 1 4 1 2 2 1 1 1 3 2 3 |
Renal Tubule, Accumulation, Hyaline | |
Droplet | |
Renal Tubule, Dilatation | 3 |
Renal Tubule, Pigmentation | 3 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Inflammation, Chronic | 2 |
__________________________________________|__________________________________________________________________________
Page 8
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 3| 6| 6| 5| 6| 6| 6| 6| 5| 5| 6| 5| 6| 1| 6| 6| 6| 3| 5| 4| 6| 4| 6| 2| 6| |
DAY ON TEST | 9| 4| 7| 1| 6| 6| 0| 6| 8| 5| 7| 9| 6| 0| 1| 7| 7| 7| 8| 6| 7| 4| 7| 8| 7| |
| 1| 4| 1| 0| 9| 9| 9| 8| 8| 8| 1| 9| 8| 5| 2| 2| 1| 2| 8| 0| 1| 3| 2| 7| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 7| 7| A |
0 | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 1| 2| L |
MG/KG/DY | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 9| 1| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + A + + + + + + A + + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + + + + + + +| 47 |
Amyloid Deposition | 2 | 1 2.0|
Edema | 2 2 | 3 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition | 3 | 1 3.0|
Erosion | 2 | 1 2.0|
Epithelium, Hyperplasia | 2 2 1 2 2 2 | 12 2.1|
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + + + + + + A + + + + + + + + + + +| 46 |
Amyloid Deposition | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + A + + + M + + + + + + + + + + A + + +| 47 |
Amyloid Deposition | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition | 3 | 1 3.0|
Angiectasis | 3 | 1 3.0|
Cyst | X | 2 |
Eosinophilic Focus | X | 1 |
Hematopoietic Cell Proliferation | 4 2 3 | 8 3.0|
Infiltration Cellular, Mixed Cell | 1 2 2 2 | 7 2.0|
Necrosis, Focal | 1 | 6 2.2|
Thrombosis | X | 1 |
Hepatocyte, Hypertrophy | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 3| 6| 6| 5| 6| 6| 6| 6| 5| 5| 6| 5| 6| 1| 6| 6| 6| 3| 5| 4| 6| 4| 6| 2| 6| |
DAY ON TEST | 9| 4| 7| 1| 6| 6| 0| 6| 8| 5| 7| 9| 6| 0| 1| 7| 7| 7| 8| 6| 7| 4| 7| 8| 7| |
| 1| 4| 1| 0| 9| 9| 9| 8| 8| 8| 1| 9| 8| 5| 2| 2| 1| 2| 8| 0| 1| 3| 2| 7| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 7| 7| A |
0 | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 1| 2| L |
MG/KG/DY | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 9| 1| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Kupffer Cell, Hyperplasia | | 1 3.0|
Kupffer Cell, Pigmentation | 1 | 4 2.0|
|__________________________________________________________________________|____________|
Mesentery | + + | 4 |
Hemorrhage | | 1 4.0|
Thrombosis | X | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis, Focal | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 2 3 | 2 2.5|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 2 | 1 2.0|
Epithelium, Hyperplasia | 1 2 | 4 1.5|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition | 2 | 1 2.0|
Erosion | | 1 2.0|
Glands, Hyperplasia, Cystic | | 6 2.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + | 3 |
Inflammation, Chronic | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition | 2 | 1 2.0|
Cardiomyopathy | | 3 1.7|
Inflammation, Chronic | 1 2 2 3 | 7 2.0|
Mineralization | | 2 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 3| 6| 6| 5| 6| 6| 6| 6| 5| 5| 6| 5| 6| 1| 6| 6| 6| 3| 5| 4| 6| 4| 6| 2| 6| |
DAY ON TEST | 9| 4| 7| 1| 6| 6| 0| 6| 8| 5| 7| 9| 6| 0| 1| 7| 7| 7| 8| 6| 7| 4| 7| 8| 7| |
| 1| 4| 1| 0| 9| 9| 9| 8| 8| 8| 1| 9| 8| 5| 2| 2| 1| 2| 8| 0| 1| 3| 2| 7| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 7| 7| A |
0 | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 1| 2| L |
MG/KG/DY | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 9| 1| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 3 3 3 3 3 3 | 10 3.0|
Amyloid Deposition | 3 | 1 3.0|
Capsule, Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 1.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 2 1.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + + +| 45 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Cyst | X X| 3 |
Pars Distalis, Hyperplasia, Focal | 3 1 | 3 1.7|
Pars Intermedia, Hyperplasia | | 1 3.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition | 3 | 1 3.0|
Degeneration, Cystic | 3 1 2 2 1 1 2 1 2 3 2 3 1 2 | 26 2.1|
Follicular Cell, Hyperplasia | 1 2 1 | 4 1.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X X X X X X X X X X X X X X X| 22 |
Inflammation, Chronic | 2 4 2 2 2 3 2 2 2 1 2 2| 23 2.5|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 3| 6| 6| 5| 6| 6| 6| 6| 5| 5| 6| 5| 6| 1| 6| 6| 6| 3| 5| 4| 6| 4| 6| 2| 6| |
DAY ON TEST | 9| 4| 7| 1| 6| 6| 0| 6| 8| 5| 7| 9| 6| 0| 1| 7| 7| 7| 8| 6| 7| 4| 7| 8| 7| |
| 1| 4| 1| 0| 9| 9| 9| 8| 8| 8| 1| 9| 8| 5| 2| 2| 1| 2| 8| 0| 1| 3| 2| 7| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 7| 7| A |
0 | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 1| 2| L |
MG/KG/DY | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 9| 1| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Amyloid Deposition | 4 | 1 4.0|
Angiectasis | 2 | 1 2.0|
Cyst | X X X X X X X X X X X X X X X X| 38 |
Hematocyst | | 1 |
Hemorrhage | 2 | 2 2.5|
Corpus Luteum, Hyperplasia | 3| 1 3.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 4.0|
Inflammation, Chronic | | 1 3.0|
Thrombosis | X | 2 |
Endometrium, Hyperplasia, Cystic | 3 2 3 2 2 2| 22 2.2|
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + + + + I + + + + + + + + + + +| 49 |
Cyst | X | 2 |
Epithelium, Hyperplasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 4 2 3 2 2 3 3 2 3 4 2 3 | 33 3.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + | 14 |
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Hyperplasia, Lymphoid | | 1 4.0|
Hyperplasia, Plasma Cell | 4 | 2 3.5|
Iliac, Hematopoietic Cell | | |
Proliferation | | 1 4.0|
Inguinal, Hyperplasia, Lymphoid | 4 2 | 2 3.0|
Inguinal, Hyperplasia, Plasma Cell | 3 | 1 3.0|
Lumbar, Hematopoietic Cell | | |
Proliferation | | 1 3.0|
Mediastinal, Hematopoietic Cell | | |
Proliferation | | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 3| 6| 6| 5| 6| 6| 6| 6| 5| 5| 6| 5| 6| 1| 6| 6| 6| 3| 5| 4| 6| 4| 6| 2| 6| |
DAY ON TEST | 9| 4| 7| 1| 6| 6| 0| 6| 8| 5| 7| 9| 6| 0| 1| 7| 7| 7| 8| 6| 7| 4| 7| 8| 7| |
| 1| 4| 1| 0| 9| 9| 9| 8| 8| 8| 1| 9| 8| 5| 2| 2| 1| 2| 8| 0| 1| 3| 2| 7| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 7| 7| A |
0 | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 1| 2| L |
MG/KG/DY | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 9| 1| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Mediastinal, Hemorrhage | | 1 4.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Amyloid Deposition | 3 | 1 3.0|
Atrophy | 2 | 2 2.5|
Ectasia | | 2 4.0|
Hematopoietic Cell Proliferation | 2 2 2 | 7 2.1|
Hemorrhage | 3 | 3 3.3|
Hyperplasia, Lymphoid | 2 3 | 9 3.1|
Hyperplasia, Plasma Cell | 3 | 5 3.2|
Infiltration Cellular, Plasma Cell | | 2 3.0|
Pigmentation | 2 | 5 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 2 3.0|
Ectasia | 2 2 | 2 2.0|
Hematopoietic Cell Proliferation | 3 2 4 2 | 6 2.7|
Hemorrhage | 2 2 2 3 2 3 3 2 | 12 2.5|
Hyperplasia, Lymphoid | 2 2 2 | 6 1.7|
Pigmentation | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 4 3 2 1 2 2 4 4 1 2 3 4 4 2 2 | 31 2.8|
Pigmentation | 2 3 2 2 3 2 3 | 13 2.5|
Lymphoid Follicle, Atrophy | 3 | 4 3.3|
Lymphoid Follicle, Hyperplasia | 2 2 2 | 7 2.4|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 2 3 | 7 2.6|
Hemorrhage | 3 | 1 3.0|
Hyperplasia, Lymphoid | 3 3 3 2 | 7 2.7|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 3| 6| 6| 5| 6| 6| 6| 6| 5| 5| 6| 5| 6| 1| 6| 6| 6| 3| 5| 4| 6| 4| 6| 2| 6| |
DAY ON TEST | 9| 4| 7| 1| 6| 6| 0| 6| 8| 5| 7| 9| 6| 0| 1| 7| 7| 7| 8| 6| 7| 4| 7| 8| 7| |
| 1| 4| 1| 0| 9| 9| 9| 8| 8| 8| 1| 9| 8| 5| 2| 2| 1| 2| 8| 0| 1| 3| 2| 7| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 7| 7| A |
0 | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 1| 2| L |
MG/KG/DY | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 9| 1| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 | 9 2.1|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 2 | 3 3.0|
Inflammation, Chronic | | 1 2.0|
Ulcer | 4 | 8 3.9|
Epidermis, Hyperplasia | 4 | 7 3.4|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | | 2 2.5|
|__________________________________________________________________________|____________|
Skeletal Muscle | + + | 5 |
Inflammation, Chronic | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + | 7 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | | 1 3.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 2.0|
Foreign Body | | 3 |
Hemorrhage | 2 1 1 2 1 | 7 1.6|
Hyperplasia, Lymphoid | 2 | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 3| 6| 6| 5| 6| 6| 6| 6| 5| 5| 6| 5| 6| 1| 6| 6| 6| 3| 5| 4| 6| 4| 6| 2| 6| |
DAY ON TEST | 9| 4| 7| 1| 6| 6| 0| 6| 8| 5| 7| 9| 6| 0| 1| 7| 7| 7| 8| 6| 7| 4| 7| 8| 7| |
| 1| 4| 1| 0| 9| 9| 9| 8| 8| 8| 1| 9| 8| 5| 2| 2| 1| 2| 8| 0| 1| 3| 2| 7| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 7| 7| A |
0 | 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 1| 2| L |
MG/KG/DY | 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 9| 1| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Infiltration Cellular, Histiocyte | 3 2 1 4 3 | 12 2.3|
Infiltration Cellular, Mixed Cell | | 2 2.5|
Inflammation, Chronic | | 1 2.0|
Alveolar Epithelium, Hyperplasia | 2 | 2 1.5|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 2 |
Inflammation, Chronic | 1 1 2| 11 1.6|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition | 3 4 | 2 3.5|
Cyst | X X | 2 |
Hydronephrosis | 2 | 2 1.5|
Infiltration Cellular, Mixed Cell | 1 2 2 2 3 | 10 2.1|
Inflammation, Chronic | 2 | 3 3.0|
Metaplasia, Osseous | | 1 1.0|
Nephropathy | 2 1 2 2 1 2 1 2 3 1 4 2 1 4 | 29 2.0|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | 4 | 1 4.0|
Renal Tubule, Dilatation | | 1 3.0|
Renal Tubule, Pigmentation | | 1 3.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
Inflammation, Chronic | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 6| 6| 3| 5| 5| 6| 6| 6| 6| 5| 6| 6| 5| 4| 4| 5| 2| 6| 5| 5| 3| 5| 5| 6| 6|
DAY ON TEST | 7| 7| 6| 0| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 4| 0| 1| 7| 6| 3| 4| 5| 4| 7| 4|
| 7| 9| 9| 0| 7| 5| 5| 8| 7| 7| 7| 7| 6| 6| 1| 0| 9| 6| 5| 9| 1| 9| 9| 9| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
50 | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|
MG/KG/DY | 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + A + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + M + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 2 3 |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Epithelium, Hyperplasia | 2 3 3 2 |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 2|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Eosinophilic Focus | X |
Hematopoietic Cell Proliferation | 3 4 |
Infiltration Cellular, Mixed Cell | 2 3 3 |
Necrosis, Focal | 4 3 2 4 1 4 |
Regeneration | |
Hepatocyte, Hypertrophy | 2 2 |
Hepatocyte, Vacuolization Cytoplasmic| |
Kupffer Cell, Pigmentation | 2 3 2 |
|__________________________________________________________________________|
Mesentery | + + + + + + +|
Hemorrhage | 3|
Fat, Necrosis | 4 4 2 4 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
__________________________________________|__________________________________________________________________________|
Page 16
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 6| 6| 3| 5| 5| 6| 6| 6| 6| 5| 6| 6| 5| 4| 4| 5| 2| 6| 5| 5| 3| 5| 5| 6| 6|
DAY ON TEST | 7| 7| 6| 0| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 4| 0| 1| 7| 6| 3| 4| 5| 4| 7| 4|
| 7| 9| 9| 0| 7| 5| 5| 8| 7| 7| 7| 7| 6| 6| 1| 0| 9| 6| 5| 9| 1| 9| 9| 9| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
50 | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|
MG/KG/DY | 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Edema | |
Acinus, Cytoplasmic Alteration | 3 3|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 2 2 2|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 2 |
Epithelium, Hyperplasia | 1 1 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Edema | 2 |
Erosion | 2 |
Glands, Hyperplasia, Cystic | 3 2 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Inflammation, Chronic | |
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 3 3 3 3 3 |
Hyperplasia, Diffuse | 2 2 |
Capsule, Hyperplasia | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 3 |
|__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + M + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 17
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 6| 6| 3| 5| 5| 6| 6| 6| 6| 5| 6| 6| 5| 4| 4| 5| 2| 6| 5| 5| 3| 5| 5| 6| 6|
DAY ON TEST | 7| 7| 6| 0| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 4| 0| 1| 7| 6| 3| 4| 5| 4| 7| 4|
| 7| 9| 9| 0| 7| 5| 5| 8| 7| 7| 7| 7| 6| 6| 1| 0| 9| 6| 5| 9| 1| 9| 9| 9| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
50 | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|
MG/KG/DY | 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia, Focal | 2 2 1 3|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Degeneration, Cystic | 3 3 2 4 2 2 3 2 |
Follicular Cell, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X X X X |
Inflammation, Chronic | 3 3 2 3 2 2 2 3 4 3 3 2 2 4|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Cyst | X X X X X X X X X X X X X X X X X|
Hemorrhage | 3 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Inflammation, Chronic | 2 |
Endometrium, Hyperplasia, Cystic | 4 3 1 2 3 2 1 3 2 2 2 3 2 3 3 3 3|
|__________________________________________________________________________|
Vagina | + + + + + + + + + + + + + + + + + M + + + + + + +|
Epithelium, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 2 2 3 4 4 3 4 4 2 3|
Myelofibrosis | |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + |
Hematopoietic Cell Proliferation | |
Hyperplasia, Lymphoid | 4 |
__________________________________________|__________________________________________________________________________|
Page 18
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 6| 6| 3| 5| 5| 6| 6| 6| 6| 5| 6| 6| 5| 4| 4| 5| 2| 6| 5| 5| 3| 5| 5| 6| 6|
DAY ON TEST | 7| 7| 6| 0| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 4| 0| 1| 7| 6| 3| 4| 5| 4| 7| 4|
| 7| 9| 9| 0| 7| 5| 5| 8| 7| 7| 7| 7| 6| 6| 1| 0| 9| 6| 5| 9| 1| 9| 9| 9| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
50 | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|
MG/KG/DY | 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Bronchial, Hemorrhage | |
Iliac, Hematopoietic Cell | |
Proliferation | |
Iliac, Hyperplasia, Lymphoid | |
Inguinal, Hematopoietic Cell | |
Proliferation | |
Inguinal, Hyperplasia, Lymphoid | 4 |
Inguinal, Pigmentation | 1 |
Lumbar, Hyperplasia, Lymphoid | |
Mediastinal, Hemorrhage | |
Mediastinal, Hyperplasia, Lymphoid | |
Mediastinal, Pigmentation | |
Renal, Ectasia | 3 |
Renal, Hematopoietic Cell | |
Proliferation | 2 |
Renal, Hemorrhage | 2 3 |
Renal, Hyperplasia, Lymphoid | 3 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + I + + + + + + + + + + + + + + + + + I + + + + +|
Atrophy | 3 |
Ectasia | |
Hematopoietic Cell Proliferation | |
Hemorrhage | 2 2 1 2 |
Hyperplasia, Lymphoid | 2 3 2 3|
Pigmentation | 3 2 2|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 |
Ectasia | 2 3 |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | 2 2 2 3 |
Hyperplasia, Lymphoid | 2 2 3|
Pigmentation | 2 2 2 2 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 1 2 2 3 3 4 2 4 2 3 3|
Pigmentation | 2 2 3 3 2 2 2 2 2 2 2 3 4 3 |
Lymphoid Follicle, Atrophy | 3 3 |
__________________________________________|__________________________________________________________________________|
Page 19
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 6| 6| 3| 5| 5| 6| 6| 6| 6| 5| 6| 6| 5| 4| 4| 5| 2| 6| 5| 5| 3| 5| 5| 6| 6|
DAY ON TEST | 7| 7| 6| 0| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 4| 0| 1| 7| 6| 3| 4| 5| 4| 7| 4|
| 7| 9| 9| 0| 7| 5| 5| 8| 7| 7| 7| 7| 6| 6| 1| 0| 9| 6| 5| 9| 1| 9| 9| 9| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
50 | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|
MG/KG/DY | 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Lymphoid Follicle, Hyperplasia | 2 2 |
|__________________________________________________________________________|
Thymus | + + + + + + + I + + + + + + + + M + + + + + + + +|
Atrophy | |
Hemorrhage | 4 2 4 |
Hyperplasia, Lymphoid | 3 4 3|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 3|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 3 |
Ulcer | |
Epidermis, Hyperplasia | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 3 |
Cranium, Hyperostosis | 3 |
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Compression | 4 |
Hemorrhage | |
Necrosis | 3 |
|__________________________________________________________________________|
Peripheral Nerve | + + + |
Atrophy | 2 |
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 2 |
__________________________________________|__________________________________________________________________________|
Page 20
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 6| 6| 3| 5| 5| 6| 6| 6| 6| 5| 6| 6| 5| 4| 4| 5| 2| 6| 5| 5| 3| 5| 5| 6| 6|
DAY ON TEST | 7| 7| 6| 0| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 4| 0| 1| 7| 6| 3| 4| 5| 4| 7| 4|
| 7| 9| 9| 0| 7| 5| 5| 8| 7| 7| 7| 7| 6| 6| 1| 0| 9| 6| 5| 9| 1| 9| 9| 9| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
50 | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|
MG/KG/DY | 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hemorrhage | 3 3 2 |
Hyperplasia, Lymphoid | 2 |
Infiltration Cellular, Histiocyte | 2 2 3 3 4 1 |
Alveolar Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X |
Hydronephrosis | 3 2 3 3 3 |
Infarct | 2 |
Infiltration Cellular, Mixed Cell | 2 3 3 2 3 2 2 3 2|
Nephropathy | 3 4 1 4 2 1 1 3 2 4 4 1 4 3 2|
Renal Tubule, Accumulation, Hyaline | |
Droplet | 3 4|
Renal Tubule, Dilatation | 3 |
Renal Tubule, Pigmentation | 3 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Inflammation, Chronic | |
__________________________________________|__________________________________________________________________________
Page 21
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 6| 4| 5| 5| 3| 6| 6| 6| 4| 4| 4| 6| 6| 3| 6| 2| 2| 5| 3| 4| 6| 4| 5| 6| 6| |
DAY ON TEST | 5| 7| 6| 3| 2| 7| 7| 7| 1| 7| 0| 7| 0| 5| 6| 9| 0| 6| 9| 7| 7| 1| 2| 6| 6| |
| 5| 2| 0| 6| 6| 1| 1| 2| 2| 5| 2| 2| 0| 0| 8| 0| 7| 0| 5| 5| 7| 7| 1| 8| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
50 | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 3| 3| 3| 3| L |
MG/KG/DY | 4| 6| 7| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 4| 1| 3| 5| 6| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + A + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
Edema | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + A + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + A + A + + + + + + + + +| 48 |
Edema | | 3 2.7|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | | 1 2.0|
Epithelium, Hyperplasia | 2 2 2 | 7 2.3|
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
Epithelium, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + M + A + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Eosinophilic Focus | X | 2 |
Hematopoietic Cell Proliferation | 2 4 4 | 5 3.4|
Infiltration Cellular, Mixed Cell | 3 2 2 | 6 2.5|
Necrosis, Focal | 1 1 | 8 2.5|
Regeneration | 3 | 1 3.0|
Hepatocyte, Hypertrophy | 2 3 2 2 | 6 2.2|
Hepatocyte, Vacuolization Cytoplasmic| 4 | 1 4.0|
Kupffer Cell, Pigmentation | 2 | 4 2.3|
|__________________________________________________________________________|____________|
Mesentery | + | 8 |
Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 6| 4| 5| 5| 3| 6| 6| 6| 4| 4| 4| 6| 6| 3| 6| 2| 2| 5| 3| 4| 6| 4| 5| 6| 6| |
DAY ON TEST | 5| 7| 6| 3| 2| 7| 7| 7| 1| 7| 0| 7| 0| 5| 6| 9| 0| 6| 9| 7| 7| 1| 2| 6| 6| |
| 5| 2| 0| 6| 6| 1| 1| 2| 2| 5| 2| 2| 0| 0| 8| 0| 7| 0| 5| 5| 7| 7| 1| 8| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
50 | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 3| 3| 3| 3| L |
MG/KG/DY | 4| 6| 7| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 4| 1| 3| 5| 6| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Fat, Necrosis | 3 | 5 3.4|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
Atrophy | 2 | 1 2.0|
Edema | 2 2 | 2 2.0|
Acinus, Cytoplasmic Alteration | 3 3 | 4 3.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | 2 | 6 2.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 2 3 2 | 5 2.2|
Epithelium, Hyperplasia | 1 | 3 1.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 2 |
Edema | 2 | 2 2.0|
Erosion | 2 | 2 2.0|
Glands, Hyperplasia, Cystic | 2 2 3 2 2 2 2 3 2| 12 2.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Cardiomyopathy | 2 1 | 2 1.5|
Inflammation, Chronic | 3 | 1 3.0|
Mineralization | 3 1 | 3 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
Accessory Adrenal Cortical Nodule | 3 3 3 | 8 3.0|
Hyperplasia, Diffuse | | 2 2.0|
Capsule, Hyperplasia | 3 | 1 3.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 6| 4| 5| 5| 3| 6| 6| 6| 4| 4| 4| 6| 6| 3| 6| 2| 2| 5| 3| 4| 6| 4| 5| 6| 6| |
DAY ON TEST | 5| 7| 6| 3| 2| 7| 7| 7| 1| 7| 0| 7| 0| 5| 6| 9| 0| 6| 9| 7| 7| 1| 2| 6| 6| |
| 5| 2| 0| 6| 6| 1| 1| 2| 2| 5| 2| 2| 0| 0| 8| 0| 7| 0| 5| 5| 7| 7| 1| 8| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
50 | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 3| 3| 3| 3| L |
MG/KG/DY | 4| 6| 7| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 4| 1| 3| 5| 6| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Adrenal Medulla | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
Hyperplasia | 1 | 3 1.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + A + + + + + + + + +| 49 |
Hyperplasia | 2 | 5 2.2|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + + + + + + + M M + + + + + + + + +| 45 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +| 49 |
Pars Distalis, Hyperplasia, Focal | | 4 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Degeneration, Cystic | 4 3 3 1 2 2 2 3 2 3 | 18 2.6|
Follicular Cell, Hyperplasia | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X X X X X X X X X | 18 |
Inflammation, Chronic | 2 3 2 2 2 | 19 2.6|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Cyst | X X X X X X X X X X X X X X X X X X| 35 |
Hemorrhage | 2 | 2 2.5|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 2.0|
Inflammation, Chronic | | 1 2.0|
Endometrium, Hyperplasia, Cystic | 2 3 2 3 1 3 3 2 3 3| 27 2.5|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 6| 4| 5| 5| 3| 6| 6| 6| 4| 4| 4| 6| 6| 3| 6| 2| 2| 5| 3| 4| 6| 4| 5| 6| 6| |
DAY ON TEST | 5| 7| 6| 3| 2| 7| 7| 7| 1| 7| 0| 7| 0| 5| 6| 9| 0| 6| 9| 7| 7| 1| 2| 6| 6| |
| 5| 2| 0| 6| 6| 1| 1| 2| 2| 5| 2| 2| 0| 0| 8| 0| 7| 0| 5| 5| 7| 7| 1| 8| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
50 | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 3| 3| 3| 3| L |
MG/KG/DY | 4| 6| 7| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 4| 1| 3| 5| 6| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Vagina | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Epithelium, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 3 4 3 4 2 2 4 4 2 2 3| 24 3.1|
Myelofibrosis | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + +| 23 |
Hematopoietic Cell Proliferation | 4 | 1 4.0|
Hyperplasia, Lymphoid | 4 4 | 3 4.0|
Bronchial, Hemorrhage | 3 | 1 3.0|
Iliac, Hematopoietic Cell | | |
Proliferation | 3 | 1 3.0|
Iliac, Hyperplasia, Lymphoid | 4 4 | 2 4.0|
Inguinal, Hematopoietic Cell | | |
Proliferation | 3 | 1 3.0|
Inguinal, Hyperplasia, Lymphoid | 4 2 4 | 4 3.5|
Inguinal, Pigmentation | | 1 1.0|
Lumbar, Hyperplasia, Lymphoid | 4 | 1 4.0|
Mediastinal, Hemorrhage | 2 | 1 2.0|
Mediastinal, Hyperplasia, Lymphoid | 2 2 | 2 2.0|
Mediastinal, Pigmentation | 2 | 1 2.0|
Renal, Ectasia | | 1 3.0|
Renal, Hematopoietic Cell | | |
Proliferation | | 1 2.0|
Renal, Hemorrhage | | 2 2.5|
Renal, Hyperplasia, Lymphoid | 4 4 | 3 3.7|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + + + + + + + + +| 47 |
Atrophy | 3 | 2 3.0|
Ectasia | 4 | 1 4.0|
Hematopoietic Cell Proliferation | 3 3 3 | 3 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 6| 4| 5| 5| 3| 6| 6| 6| 4| 4| 4| 6| 6| 3| 6| 2| 2| 5| 3| 4| 6| 4| 5| 6| 6| |
DAY ON TEST | 5| 7| 6| 3| 2| 7| 7| 7| 1| 7| 0| 7| 0| 5| 6| 9| 0| 6| 9| 7| 7| 1| 2| 6| 6| |
| 5| 2| 0| 6| 6| 1| 1| 2| 2| 5| 2| 2| 0| 0| 8| 0| 7| 0| 5| 5| 7| 7| 1| 8| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
50 | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 3| 3| 3| 3| L |
MG/KG/DY | 4| 6| 7| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 4| 1| 3| 5| 6| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Hemorrhage | | 4 1.8|
Hyperplasia, Lymphoid | 4 4 2 4 2 2 | 10 2.8|
Pigmentation | 2 | 4 2.3|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + M + + + + + M + + + + + + + + +| 48 |
Atrophy | 3 3 | 4 2.8|
Ectasia | 2 | 3 2.3|
Hematopoietic Cell Proliferation | 2 3 2 2 2 | 6 2.2|
Hemorrhage | 2 2 2 3 1 2| 10 2.1|
Hyperplasia, Lymphoid | 3 2 2 3 | 7 2.4|
Pigmentation | 2 2 2| 7 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 3 4 4 2 4 3 3 2 3| 21 2.8|
Pigmentation | 3 2 2 3 2 3 3 2 2 2| 24 2.4|
Lymphoid Follicle, Atrophy | 2 2 2 3 | 6 2.5|
Lymphoid Follicle, Hyperplasia | 2 | 3 2.0|
|__________________________________________________________________________|____________|
Thymus | + + M M + + + + + + + + + + + M M + + + + + + + +| 44 |
Atrophy | 2 2 2 | 3 2.0|
Hemorrhage | 2 | 4 3.0|
Hyperplasia, Lymphoid | | 3 3.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 3 3 1 3 | 9 2.4|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 3 3 3 3 | 7 3.0|
Ulcer | 4 4 4 4 4 | 5 4.0|
Epidermis, Hyperplasia | 4 4 4 3 4 | 5 3.8|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 6| 4| 5| 5| 3| 6| 6| 6| 4| 4| 4| 6| 6| 3| 6| 2| 2| 5| 3| 4| 6| 4| 5| 6| 6| |
DAY ON TEST | 5| 7| 6| 3| 2| 7| 7| 7| 1| 7| 0| 7| 0| 5| 6| 9| 0| 6| 9| 7| 7| 1| 2| 6| 6| |
| 5| 2| 0| 6| 6| 1| 1| 2| 2| 5| 2| 2| 0| 0| 8| 0| 7| 0| 5| 5| 7| 7| 1| 8| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
50 | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 3| 3| 3| 3| L |
MG/KG/DY | 4| 6| 7| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 4| 1| 3| 5| 6| |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 2 2 2 3 2 2 | 7 2.3|
Cranium, Hyperostosis | | 1 3.0|
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Compression | | 1 4.0|
Hemorrhage | 3 | 1 3.0|
Necrosis | | 1 3.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | + + | 5 |
Atrophy | | 1 2.0|
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Edema | 4 2 4 | 3 3.3|
Hemorrhage | 2 4 2 | 6 2.7|
Hyperplasia, Lymphoid | | 1 2.0|
Infiltration Cellular, Histiocyte | 3 4 4 3 4 | 11 3.0|
Alveolar Epithelium, Hyperplasia | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 | 2 1.5|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 6| 4| 5| 5| 3| 6| 6| 6| 4| 4| 4| 6| 6| 3| 6| 2| 2| 5| 3| 4| 6| 4| 5| 6| 6| |
DAY ON TEST | 5| 7| 6| 3| 2| 7| 7| 7| 1| 7| 0| 7| 0| 5| 6| 9| 0| 6| 9| 7| 7| 1| 2| 6| 6| |
| 5| 2| 0| 6| 6| 1| 1| 2| 2| 5| 2| 2| 0| 0| 8| 0| 7| 0| 5| 5| 7| 7| 1| 8| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| A |
50 | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 3| 3| 3| 3| L |
MG/KG/DY | 4| 6| 7| 9| 0| 2| 3| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 4| 1| 3| 5| 6| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X | 7 |
Hydronephrosis | 2 2 | 7 2.6|
Infarct | | 1 2.0|
Infiltration Cellular, Mixed Cell | 2 3 3 2 3 2 3 2 2 2 2 | 20 2.4|
Nephropathy | 3 4 2 4 4 4 3 1 4 4 2 1 2 3 1 1| 31 2.6|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | | 2 3.5|
Renal Tubule, Dilatation | 2 4 | 3 3.0|
Renal Tubule, Pigmentation | | 1 3.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
Inflammation, Chronic | 4 | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 5| 6| 6| 6| 5| 4| 3| 5| 6| 6| 6| 6| 6| 1| 6| 1| 6| 4| 2| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 7| 7| 7| 7| 1| 6| 3| 9| 1| 7| 7| 7| 7| 8| 7| 8| 1| 3| 3| 5| 7| 7| 7| 2| 6|
| 4| 5| 7| 5| 4| 0| 2| 0| 2| 8| 5| 5| 8| 2| 7| 1| 9| 2| 7| 4| 8| 9| 9| 1| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
100 | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
MG/KG/DY | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + A A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + + + + + + +|
Edema | 2 2 3 |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + M + + + + + + + + + + + + + + + + + +|
Ulcer | |
Epithelium, Hyperplasia | 2 3 2 2 2 3 2|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A A + + + + + +|
Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Cyst | |
Eosinophilic Focus | X X |
Hematopoietic Cell Proliferation | 4 2 3 |
Infiltration Cellular, Mixed Cell | 3 1 3 2 |
Necrosis, Focal | 1 3 |
Hepatocyte, Hypertrophy | 2 |
Hepatocyte, Vacuolization Cytoplasmic| 2 3 |
Kupffer Cell, Hyperplasia | 3 |
Kupffer Cell, Pigmentation | 2 |
|__________________________________________________________________________|
Mesentery | + + |
Angiectasis | |
Fat, Necrosis | 4 4 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 29
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 5| 6| 6| 6| 5| 4| 3| 5| 6| 6| 6| 6| 6| 1| 6| 1| 6| 4| 2| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 7| 7| 7| 7| 1| 6| 3| 9| 1| 7| 7| 7| 7| 8| 7| 8| 1| 3| 3| 5| 7| 7| 7| 2| 6|
| 4| 5| 7| 5| 4| 0| 2| 0| 2| 8| 5| 5| 8| 2| 7| 1| 9| 2| 7| 4| 8| 9| 9| 1| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
100 | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
MG/KG/DY | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + M + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 2 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Erosion | 3 |
Glands, Hyperplasia, Cystic | 2 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 |
Inflammation, Chronic | 2|
Mineralization | |
Thrombosis | X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 3 3 3 3 3 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + M + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 30
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 5| 6| 6| 6| 5| 4| 3| 5| 6| 6| 6| 6| 6| 1| 6| 1| 6| 4| 2| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 7| 7| 7| 7| 1| 6| 3| 9| 1| 7| 7| 7| 7| 8| 7| 8| 1| 3| 3| 5| 7| 7| 7| 2| 6|
| 4| 5| 7| 5| 4| 0| 2| 0| 2| 8| 5| 5| 8| 2| 7| 1| 9| 2| 7| 4| 8| 9| 9| 1| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
100 | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
MG/KG/DY | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Pars Distalis, Angiectasis | |
Pars Distalis, Hyperplasia, Focal | |
Pars Intermedia, Hyperplasia | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 3 3 4 2 2 1 1 1 3 3 1 3 3 3 1 2 |
Follicular Cell, Hyperplasia | 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X X X X X X X X X |
Inflammation, Chronic | 3 2 2 2 2 2 2 4 2 4 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Cyst | X X X X X X X X X X X X X X X X X X|
Hemorrhage | 3 3 2 3 4 4 |
Thrombosis | |
Corpus Luteum, Hyperplasia | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Hemorrhage | 2 |
Thrombosis | X X |
Endometrium, Hyperplasia, Cystic | 3 2 3 3 2 3 1 3 3 3 2 3 4 2 2|
|__________________________________________________________________________|
Vagina | + + M + + + + + + + + + + + + + + + M + + + + + +|
Cyst | X |
Epithelium, Hyperplasia | 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 3 4 2 2 3 2 4 3 4 2 2 2 4|
__________________________________________|__________________________________________________________________________|
Page 31
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 5| 6| 6| 6| 5| 4| 3| 5| 6| 6| 6| 6| 6| 1| 6| 1| 6| 4| 2| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 7| 7| 7| 7| 1| 6| 3| 9| 1| 7| 7| 7| 7| 8| 7| 8| 1| 3| 3| 5| 7| 7| 7| 2| 6|
| 4| 5| 7| 5| 4| 0| 2| 0| 2| 8| 5| 5| 8| 2| 7| 1| 9| 2| 7| 4| 8| 9| 9| 1| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
100 | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
MG/KG/DY | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Lymph Node | + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | 3 |
Iliac, Hematopoietic Cell | |
Proliferation | |
Iliac, Hyperplasia, Lymphoid | 3 |
Inguinal, Hyperplasia, Lymphoid | 3 3 |
Mediastinal, Hemorrhage | 4 |
Popliteal, Hyperplasia | 4 |
Renal, Hemorrhage | |
Renal, Hyperplasia, Lymphoid | 3 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + M + + + + + + + + + + + + + + + +|
Atrophy | |
Hematopoietic Cell Proliferation | 1 |
Hemorrhage | 3 3 |
Hyperplasia, Lymphoid | 2 2 3 2 2 2 3|
Pigmentation | 2 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + M + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Ectasia | 2 |
Hematopoietic Cell Proliferation | 2 3 |
Hemorrhage | 4 4 2 2 3 2 |
Hyperplasia, Lymphoid | 3 3 3 2 2 |
Pigmentation | 2 2 2 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 3 2 1 1 2 2 4 1 4 4 1 1 1 2 |
Pigmentation | 3 2 2 |
Lymphoid Follicle, Atrophy | 3 2 4 |
Lymphoid Follicle, Hyperplasia | 2 2 |
|__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 |
Hemorrhage | |
Hyperplasia, Lymphoid | 3 |
__________________________________________|__________________________________________________________________________|
Page 32
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 5| 6| 6| 6| 5| 4| 3| 5| 6| 6| 6| 6| 6| 1| 6| 1| 6| 4| 2| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 7| 7| 7| 7| 1| 6| 3| 9| 1| 7| 7| 7| 7| 8| 7| 8| 1| 3| 3| 5| 7| 7| 7| 2| 6|
| 4| 5| 7| 5| 4| 0| 2| 0| 2| 8| 5| 5| 8| 2| 7| 1| 9| 2| 7| 4| 8| 9| 9| 1| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
100 | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
MG/KG/DY | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 2 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 2 3 3 |
Inflammation, Chronic | |
Ulcer | |
Epidermis, Hyperplasia | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 3 3 3 |
Hyperostosis | |
|__________________________________________________________________________|
Skeletal Muscle | |
Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
|__________________________________________________________________________|
Peripheral Nerve | + + |
Atrophy | |
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Fibrosis, Focal | 2 |
Hemorrhage | 1 1 2 |
Hyperplasia, Lymphoid | 2 4 |
Infiltration Cellular, Histiocyte | 3 2 4 2 2 3 3 1 4 4 4|
__________________________________________|__________________________________________________________________________|
Page 33
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 5| 6| 6| 6| 5| 4| 3| 5| 6| 6| 6| 6| 6| 1| 6| 1| 6| 4| 2| 6| 6| 6| 6| 6| 6|
DAY ON TEST | 7| 7| 7| 7| 1| 6| 3| 9| 1| 7| 7| 7| 7| 8| 7| 8| 1| 3| 3| 5| 7| 7| 7| 2| 6|
| 4| 5| 7| 5| 4| 0| 2| 0| 2| 8| 5| 5| 8| 2| 7| 1| 9| 2| 7| 4| 8| 9| 9| 1| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|
100 | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
MG/KG/DY | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Alveolar Epithelium, Hyperplasia | 1 2 2 2 3 3 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + |
Atrophy | 4 |
Inflammation, Chronic | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Hyperplasia, Focal | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Cyst | X X |
Hydronephrosis | 2 2 2 |
Infarct | 4 |
Infiltration Cellular, Mixed Cell | 2 2 2 3 3 2 3 |
Nephropathy | 1 1 1 3 2 4 4 4 4 1 1 1 2 1 1 4 4 1 1 1 4 2|
Renal Tubule, Accumulation, Hyaline | |
Droplet | |
Renal Tubule, Necrosis | 2 |
Renal Tubule, Pigmentation | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________|__________________________________________________________________________
Page 34
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 3| 6| 4| 5| 6| 6| 6| 6| 6| 4| 3| 6| 5| 6| 4| 6| 3| 5| 6| 6| 6| 6| 6| 6| 6| |
DAY ON TEST | 6| 7| 2| 3| 6| 7| 7| 7| 5| 9| 2| 7| 2| 7| 9| 7| 2| 8| 3| 7| 6| 4| 6| 7| 7| |
| 2| 0| 5| 7| 6| 0| 1| 0| 0| 5| 8| 0| 4| 2| 0| 1| 2| 5| 1| 1| 9| 0| 8| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| A |
100 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 2| 3| 3| 3| L |
MG/KG/DY | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 9| 7| 8| 9| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + A A A + + + + + +| 45 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Edema | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + A + + + + + A A A + + + + + +| 45 |
Edema | 2 | 4 2.3|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A + + + + + + + +| 48 |
Ulcer | 4 3 | 2 3.5|
Epithelium, Hyperplasia | 3 2 2 4 2 | 12 2.4|
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + A A + + + + + + +| 46 |
Epithelium, Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + A + + + + + A M M + + + + + +| 45 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X | 1 |
Cyst | X | 1 |
Eosinophilic Focus | X| 3 |
Hematopoietic Cell Proliferation | 3 2 | 5 2.8|
Infiltration Cellular, Mixed Cell | 2 1| 6 2.0|
Necrosis, Focal | 1 4 3 | 5 2.4|
Hepatocyte, Hypertrophy | 2 2 | 3 2.0|
Hepatocyte, Vacuolization Cytoplasmic| 3 | 3 2.7|
Kupffer Cell, Hyperplasia | | 1 3.0|
Kupffer Cell, Pigmentation | 3 | 2 2.5|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 3| 6| 4| 5| 6| 6| 6| 6| 6| 4| 3| 6| 5| 6| 4| 6| 3| 5| 6| 6| 6| 6| 6| 6| 6| |
DAY ON TEST | 6| 7| 2| 3| 6| 7| 7| 7| 5| 9| 2| 7| 2| 7| 9| 7| 2| 8| 3| 7| 6| 4| 6| 7| 7| |
| 2| 0| 5| 7| 6| 0| 1| 0| 0| 5| 8| 0| 4| 2| 0| 1| 2| 5| 1| 1| 9| 0| 8| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| A |
100 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 2| 3| 3| 3| L |
MG/KG/DY | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 9| 7| 8| 9| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Mesentery | + + + + +| 7 |
Angiectasis | 3| 1 3.0|
Fat, Necrosis | 2 4 | 4 3.5|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Edema | | 1 2.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Lymphoid | 2 2 | 3 2.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Edema | | 3 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Edema | | 1 2.0|
Erosion | | 1 3.0|
Glands, Hyperplasia, Cystic | 2 2 3 2 2 3 | 8 2.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | | 2 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 2 | 6 1.2|
Inflammation, Chronic | 2| 2 2.0|
Mineralization | 1 1 | 2 1.0|
Thrombosis | | 3 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 3 3 3 3 3 3 | 11 3.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 3| 6| 4| 5| 6| 6| 6| 6| 6| 4| 3| 6| 5| 6| 4| 6| 3| 5| 6| 6| 6| 6| 6| 6| 6| |
DAY ON TEST | 6| 7| 2| 3| 6| 7| 7| 7| 5| 9| 2| 7| 2| 7| 9| 7| 2| 8| 3| 7| 6| 4| 6| 7| 7| |
| 2| 0| 5| 7| 6| 0| 1| 0| 0| 5| 8| 0| 4| 2| 0| 1| 2| 5| 1| 1| 9| 0| 8| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| A |
100 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 2| 3| 3| 3| L |
MG/KG/DY | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 9| 7| 8| 9| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Hyperplasia | | 1 1.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Hyperplasia | 2 2 1 | 6 1.8|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis | 2 | 1 2.0|
Pars Distalis, Hyperplasia, Focal | 3 | 1 3.0|
Pars Intermedia, Hyperplasia | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 2 2 2 1 3 3 3 3 2 3 3 2 2 3 3 1 2 2 3 3 2 2| 39 2.3|
Follicular Cell, Hyperplasia | 1 3 | 5 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X X X X X X X X X X X| 25 |
Inflammation, Chronic | 2 2 3 4 3 2 3| 17 2.6|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Angiectasis | 3 4 4 | 4 3.8|
Cyst | X X X X X X X X X X X X X X X X X X X| 37 |
Hemorrhage | 3 | 7 3.1|
Thrombosis | X X | 2 |
Corpus Luteum, Hyperplasia | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Angiectasis | 3 4 4 | 4 3.8|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 3| 6| 4| 5| 6| 6| 6| 6| 6| 4| 3| 6| 5| 6| 4| 6| 3| 5| 6| 6| 6| 6| 6| 6| 6| |
DAY ON TEST | 6| 7| 2| 3| 6| 7| 7| 7| 5| 9| 2| 7| 2| 7| 9| 7| 2| 8| 3| 7| 6| 4| 6| 7| 7| |
| 2| 0| 5| 7| 6| 0| 1| 0| 0| 5| 8| 0| 4| 2| 0| 1| 2| 5| 1| 1| 9| 0| 8| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| A |
100 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 2| 3| 3| 3| L |
MG/KG/DY | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 9| 7| 8| 9| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Hemorrhage | | 1 2.0|
Thrombosis | X | 3 |
Endometrium, Hyperplasia, Cystic | 2 4 3 2 3 3 3 4 2 4 3 2 2 2 | 29 2.7|
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + + + + + + + A + + + + + + + +| 47 |
Cyst | | 1 |
Epithelium, Hyperplasia | | 2 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 4 3 4 3 3 2 3 4 3 2 3 2 2 2| 30 2.9|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + | 16 |
Hematopoietic Cell Proliferation | 3 | 2 2.5|
Hemorrhage | | 1 3.0|
Iliac, Hematopoietic Cell | | |
Proliferation | 3 | 1 3.0|
Iliac, Hyperplasia, Lymphoid | 4 | 2 3.5|
Inguinal, Hyperplasia, Lymphoid | | 2 3.0|
Mediastinal, Hemorrhage | 3 | 2 3.5|
Popliteal, Hyperplasia | | 1 4.0|
Renal, Hemorrhage | 2 | 1 2.0|
Renal, Hyperplasia, Lymphoid | 2 | 2 2.5|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 2| 2 1.5|
Hemorrhage | 3 3 1 | 5 2.6|
Hyperplasia, Lymphoid | 2 2 4 3 4 2 2 2 2 2| 17 2.4|
Pigmentation | | 2 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + M M + + A + + + + + + + +| 46 |
Atrophy | 2 3 | 2 2.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 3| 6| 4| 5| 6| 6| 6| 6| 6| 4| 3| 6| 5| 6| 4| 6| 3| 5| 6| 6| 6| 6| 6| 6| 6| |
DAY ON TEST | 6| 7| 2| 3| 6| 7| 7| 7| 5| 9| 2| 7| 2| 7| 9| 7| 2| 8| 3| 7| 6| 4| 6| 7| 7| |
| 2| 0| 5| 7| 6| 0| 1| 0| 0| 5| 8| 0| 4| 2| 0| 1| 2| 5| 1| 1| 9| 0| 8| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| A |
100 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 2| 3| 3| 3| L |
MG/KG/DY | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 9| 7| 8| 9| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Ectasia | 3 | 2 2.5|
Hematopoietic Cell Proliferation | | 2 2.5|
Hemorrhage | 3 3 2 | 9 2.8|
Hyperplasia, Lymphoid | 2 4 2 3 | 9 2.7|
Pigmentation | | 3 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 2 1 4 2 2 1 3 2 2 3 4 2 3 4 2 2| 32 2.3|
Pigmentation | 2 3 2 2 2 3 2 2 2| 12 2.3|
Lymphoid Follicle, Atrophy | 3 2 | 5 2.8|
Lymphoid Follicle, Hyperplasia | 2 2 2 3 2 | 7 2.1|
|__________________________________________________________________________|____________|
Thymus | + + M M + + + + + + + + + + + + + + + + + + M + +| 46 |
Atrophy | 3 3 2 | 5 2.8|
Hemorrhage | 3 2| 2 2.5|
Hyperplasia, Lymphoid | 3 3 | 3 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Hyperplasia | 3 1 2 | 8 2.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Edema | 3 3 3 | 7 2.9|
Inflammation, Chronic | 2 | 1 2.0|
Ulcer | 4 | 1 4.0|
Epidermis, Hyperplasia | 4 3 1 | 3 2.7|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 1 2 2 2 3 2 | 9 2.3|
Hyperostosis | 2 | 1 2.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 3| 6| 4| 5| 6| 6| 6| 6| 6| 4| 3| 6| 5| 6| 4| 6| 3| 5| 6| 6| 6| 6| 6| 6| 6| |
DAY ON TEST | 6| 7| 2| 3| 6| 7| 7| 7| 5| 9| 2| 7| 2| 7| 9| 7| 2| 8| 3| 7| 6| 4| 6| 7| 7| |
| 2| 0| 5| 7| 6| 0| 1| 0| 0| 5| 8| 0| 4| 2| 0| 1| 2| 5| 1| 1| 9| 0| 8| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| A |
100 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 2| 3| 3| 3| L |
MG/KG/DY | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 9| 7| 8| 9| |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
Skeletal Muscle | + | 1 |
Inflammation, Chronic | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 1.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | + | 3 |
Atrophy | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | X | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 3 2 | 4 2.8|
Fibrosis, Focal | | 1 2.0|
Hemorrhage | 2 1 2 | 6 1.5|
Hyperplasia, Lymphoid | 2 | 3 2.7|
Infiltration Cellular, Histiocyte | 2 2 4 3 3 4 2 3 1 4 | 21 2.9|
Alveolar Epithelium, Hyperplasia | 2 1 2 2| 10 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 3 2 2 2 1| 7 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + | 2 |
Atrophy | | 1 4.0|
Inflammation, Chronic | 3 | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 3| 6| 4| 5| 6| 6| 6| 6| 6| 4| 3| 6| 5| 6| 4| 6| 3| 5| 6| 6| 6| 6| 6| 6| 6| |
DAY ON TEST | 6| 7| 2| 3| 6| 7| 7| 7| 5| 9| 2| 7| 2| 7| 9| 7| 2| 8| 3| 7| 6| 4| 6| 7| 7| |
| 2| 0| 5| 7| 6| 0| 1| 0| 0| 5| 8| 0| 4| 2| 0| 1| 2| 5| 1| 1| 9| 0| 8| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| A |
100 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 2| 3| 3| 3| L |
MG/KG/DY | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 9| 7| 8| 9| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 3.0|
Hyperplasia, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition | 3 | 1 3.0|
Cyst | X X X | 5 |
Hydronephrosis | 3 4 | 5 2.6|
Infarct | 4 2 | 3 3.3|
Infiltration Cellular, Mixed Cell | 2 2 2 2 3 2 3 2| 15 2.3|
Nephropathy | 4 1 3 2 4 1 2 1 4 1 2 1 4 4 3 3 1 1 1 | 41 2.2|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | 2 4 | 2 3.0|
Renal Tubule, Necrosis | | 1 2.0|
Renal Tubule, Pigmentation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + A + + + + + + + +| 49 |
Hyperplasia, Lymphoid | 3 2 | 3 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 5| 3| 5| 4| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 4| 6| 5| 6|
DAY ON TEST | 0| 7| 7| 7| 7| 6| 5| 4| 9| 7| 7| 7| 0| 7| 3| 7| 7| 7| 6| 2| 7| 8| 7| 1| 7|
| 8| 9| 6| 7| 5| 5| 9| 1| 7| 7| 7| 8| 3| 5| 9| 9| 5| 0| 9| 3| 1| 8| 2| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
200 | 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5|
MG/KG/DY | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + A + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + A A + + + + + + + + + + + + + + + + +|
Edema | 2 |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 2 2 2 |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + M + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 4 |
Cyst | X |
Eosinophilic Focus | X |
Hematopoietic Cell Proliferation | 3 3 |
Hyperplasia, Lymphoid | 2 2 2 |
Infiltration Cellular, Mixed Cell | 3 4 2 2 2 1|
Necrosis, Focal | |
Hepatocyte, Hypertrophy | 3 |
Kupffer Cell, Hyperplasia | 3 |
Kupffer Cell, Pigmentation | 2 3 3 2|
|__________________________________________________________________________|
Mesentery | + + + |
Hemorrhage | 4 |
Fat, Necrosis | 4 4 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Acinus, Cytoplasmic Alteration | 3 3 |
__________________________________________|__________________________________________________________________________|
Page 42
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 5| 3| 5| 4| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 4| 6| 5| 6|
DAY ON TEST | 0| 7| 7| 7| 7| 6| 5| 4| 9| 7| 7| 7| 0| 7| 3| 7| 7| 7| 6| 2| 7| 8| 7| 1| 7|
| 8| 9| 6| 7| 5| 5| 9| 1| 7| 7| 7| 8| 3| 5| 9| 9| 5| 0| 9| 3| 1| 8| 2| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
200 | 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5|
MG/KG/DY | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Epithelium, Hyperplasia | 3 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Glands, Hyperplasia, Cystic | 2 2 2 3 3 1 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 |
Inflammation, Chronic | 2 |
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + M + + + + + + M + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 3 3 3 3 |
Capsule, Hyperplasia | 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + M + + + + + + M + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 2 2 |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + + + + + + + + + + + M + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | 2 |
Pars Distalis, Cyst | X X |
Pars Distalis, Hyperplasia, Focal | 3 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 |
__________________________________________|__________________________________________________________________________|
Page 43
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 5| 3| 5| 4| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 4| 6| 5| 6|
DAY ON TEST | 0| 7| 7| 7| 7| 6| 5| 4| 9| 7| 7| 7| 0| 7| 3| 7| 7| 7| 6| 2| 7| 8| 7| 1| 7|
| 8| 9| 6| 7| 5| 5| 9| 1| 7| 7| 7| 8| 3| 5| 9| 9| 5| 0| 9| 3| 1| 8| 2| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
200 | 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5|
MG/KG/DY | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Degeneration, Cystic | 3 3 1 2 1 2 1 1 2 2 3 2 2 2 2 1 1 |
Follicular Cell, Hyperplasia | 2 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X X X X X X |
Infiltration Cellular, Lymphocyte | 3 |
Inflammation, Chronic | 2 2 3 2 3 4 2 3 4|
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 4 3 |
Cyst | X X X X X X X X X X X X X X X X X X|
Hemorrhage | 3 2 2 2|
Thrombosis | |
Bilateral, Cyst | |
Corpus Luteum, Hyperplasia | 3 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic | 3 2 3 2 4 3 3 3 4 4 3 2 2 2 2 3 3|
|__________________________________________________________________________|
Vagina | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 4 3 2 2 2 2 3 2 2 2 2 2 4 3 |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + |
Hyperplasia, Lymphoid | 3 |
Inguinal, Hyperplasia, Lymphoid | |
Mediastinal, Hyperplasia, Lymphoid | 4 |
Pancreatic, Hyperplasia, Lymphoid | 3 |
Popliteal, Hyperplasia, Lymphoid | 3 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 44
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 5| 3| 5| 4| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 4| 6| 5| 6|
DAY ON TEST | 0| 7| 7| 7| 7| 6| 5| 4| 9| 7| 7| 7| 0| 7| 3| 7| 7| 7| 6| 2| 7| 8| 7| 1| 7|
| 8| 9| 6| 7| 5| 5| 9| 1| 7| 7| 7| 8| 3| 5| 9| 9| 5| 0| 9| 3| 1| 8| 2| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
200 | 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5|
MG/KG/DY | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 4 |
Hematopoietic Cell Proliferation | 2 2 2 |
Hemorrhage | 2 3 |
Hyperplasia, Lymphoid | 3 2 2 4 2 3 2 3 2|
Pigmentation | 2 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Ectasia | 3 3 4 |
Hematopoietic Cell Proliferation | 3 |
Hemorrhage | 1 3 2 2|
Hyperplasia, Lymphoid | 2 3 3 2 2 3 2 |
Pigmentation | 2 2|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 |
Hematopoietic Cell Proliferation | 2 2 4 2 3 3 3 4 1 3 2 4 2 1 3 |
Pigmentation | 2 2 2 2 2 2 2 2 |
Lymphoid Follicle, Atrophy | 2 2 3 3|
Lymphoid Follicle, Hyperplasia | 2 2 3 3 2 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + M + + M + M + + +|
Atrophy | |
Hyperplasia, Lymphoid | 2 4 3 2 3 |
Thrombosis | X |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 2 2 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Edema | 3 3 2 |
Inflammation, Chronic | |
Ulcer | 3 3 2 4 |
Epidermis, Hyperplasia | 3 2 3 |
__________________________________________|__________________________________________________________________________|
Page 45
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 5| 3| 5| 4| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 4| 6| 5| 6|
DAY ON TEST | 0| 7| 7| 7| 7| 6| 5| 4| 9| 7| 7| 7| 0| 7| 3| 7| 7| 7| 6| 2| 7| 8| 7| 1| 7|
| 8| 9| 6| 7| 5| 5| 9| 1| 7| 7| 7| 8| 3| 5| 9| 9| 5| 0| 9| 3| 1| 8| 2| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
200 | 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5|
MG/KG/DY | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 3 2 3 2 |
Hyperostosis | 3 |
Myelofibrosis | 3 |
Femur, Hyperostosis | 4 |
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + + + |
Atrophy | 2 |
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Necrosis | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Hemorrhage | 1 3 |
Hyperplasia, Lymphoid | 2 4 |
Infiltration Cellular, Histiocyte | 4 2 2 3 3 4 4 4 4 |
Infiltration Cellular, Mixed Cell | 2 |
Inflammation, Chronic | 3 |
Alveolar Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 1 1 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 46
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 5| 3| 5| 4| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 4| 6| 5| 6|
DAY ON TEST | 0| 7| 7| 7| 7| 6| 5| 4| 9| 7| 7| 7| 0| 7| 3| 7| 7| 7| 6| 2| 7| 8| 7| 1| 7|
| 8| 9| 6| 7| 5| 5| 9| 1| 7| 7| 7| 8| 3| 5| 9| 9| 5| 0| 9| 3| 1| 8| 2| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
200 | 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 5|
MG/KG/DY | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 3| 4| 5| 6| 7| 8| 9| 0|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
Eye | |
Atrophy | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X|
Hydronephrosis | 3 2 2 |
Infarct | 3 3 |
Infiltration Cellular, Mixed Cell | 4 3 3 3 2 2 2 2 2 |
Nephropathy | 2 4 4 1 3 4 4 2 1 1 1 1 2 2 2 1 1|
Renal Tubule, Accumulation, Hyaline | |
Droplet | 3 3 |
Renal Tubule, Dilatation | 2 |
Renal Tubule, Necrosis | |
Renal Tubule, Pigmentation | 3 2 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 2 |
__________________________________________|__________________________________________________________________________
Page 47
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 4| 5| 6| 5| 6| 6| 5| 6| 6| 6| 5| 6| | |
DAY ON TEST | 4| 6| 6| 1| 3| 6| 7| 7| 4| 6| 6| 1| 6| 1| 7| | |
| 6| 2| 7| 4| 0| 9| 2| 1| 1| 1| 8| 4| 9| 0| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
200 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L |
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + | 39 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + | 39 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + | 38 |
Edema | 3 3 2 | 4 2.5|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + | 40 |
Epithelium, Hyperplasia | 2 | 4 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + | 38 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + | 40 |
Amyloid Deposition | | 1 4.0|
Cyst | | 1 |
Eosinophilic Focus | | 1 |
Hematopoietic Cell Proliferation | 3 3 3 | 5 3.0|
Hyperplasia, Lymphoid | | 3 2.0|
Infiltration Cellular, Mixed Cell | 3 2 2 | 9 2.3|
Necrosis, Focal | 3 1 3 2 | 4 2.3|
Hepatocyte, Hypertrophy | 2 | 2 2.5|
Kupffer Cell, Hyperplasia | | 1 3.0|
Kupffer Cell, Pigmentation | 2 2 | 6 2.3|
|__________________________________________________________________________|____________|
Mesentery | | 3 |
Hemorrhage | | 1 4.0|
Fat, Necrosis | | 2 4.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 4| 5| 6| 5| 6| 6| 5| 6| 6| 6| 5| 6| | |
DAY ON TEST | 4| 6| 6| 1| 3| 6| 7| 7| 4| 6| 6| 1| 6| 1| 7| | |
| 6| 2| 7| 4| 0| 9| 2| 1| 1| 1| 8| 4| 9| 0| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
200 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L |
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + | 40 |
Atrophy | 3 | 1 3.0|
Acinus, Cytoplasmic Alteration | | 2 3.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + | 40 |
Hyperplasia, Lymphoid | | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + | 40 |
Edema | 2 | 2 2.5|
Epithelium, Hyperplasia | 1 | 2 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + | 40 |
Glands, Hyperplasia, Cystic | 2 2 4 | 10 2.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + | 40 |
Cardiomyopathy | | 1 2.0|
Inflammation, Chronic | 3 | 2 2.5|
Mineralization | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + | 38 |
Accessory Adrenal Cortical Nodule | 3 3 3 | 7 3.0|
Capsule, Hyperplasia | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + | 38 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + | 40 |
Hyperplasia | 2 2 2 | 7 1.9|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + M + + + | 37 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 4| 5| 6| 5| 6| 6| 5| 6| 6| 6| 5| 6| | |
DAY ON TEST | 4| 6| 6| 1| 3| 6| 7| 7| 4| 6| 6| 1| 6| 1| 7| | |
| 6| 2| 7| 4| 0| 9| 2| 1| 1| 1| 8| 4| 9| 0| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
200 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L |
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + | 40 |
Pars Distalis, Angiectasis | | 1 2.0|
Pars Distalis, Cyst | X | 3 |
Pars Distalis, Hyperplasia, Focal | | 2 2.5|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + | 40 |
Amyloid Deposition | | 1 2.0|
Degeneration, Cystic | 1 1 1 1 2 2 2 | 24 1.7|
Follicular Cell, Hyperplasia | | 4 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + | 40 |
Cyst | X X X X | 14 |
Infiltration Cellular, Lymphocyte | | 1 3.0|
Inflammation, Chronic | 2 4 4 2 2 | 14 2.8|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + | 40 |
Angiectasis | | 3 3.7|
Cyst | X X X X X X X X X X | 28 |
Hemorrhage | 2 | 5 2.2|
Thrombosis | X | 1 |
Bilateral, Cyst | X | 1 |
Corpus Luteum, Hyperplasia | | 1 3.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + | 40 |
Endometrium, Hyperplasia, Cystic | 2 2 2 3 2 3 3 | 24 2.7|
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 4| 5| 6| 5| 6| 6| 5| 6| 6| 6| 5| 6| | |
DAY ON TEST | 4| 6| 6| 1| 3| 6| 7| 7| 4| 6| 6| 1| 6| 1| 7| | |
| 6| 2| 7| 4| 0| 9| 2| 1| 1| 1| 8| 4| 9| 0| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
200 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L |
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + | 40 |
Hyperplasia | 3 4 3 3 2 3 2 | 22 2.6|
|__________________________________________________________________________|____________|
Lymph Node | + + + | 12 |
Hyperplasia, Lymphoid | | 1 3.0|
Inguinal, Hyperplasia, Lymphoid | 2 | 1 2.0|
Mediastinal, Hyperplasia, Lymphoid | | 1 4.0|
Pancreatic, Hyperplasia, Lymphoid | | 1 3.0|
Popliteal, Hyperplasia, Lymphoid | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + | 40 |
Ectasia | 3 2 | 3 3.0|
Hematopoietic Cell Proliferation | 2 | 4 2.0|
Hemorrhage | 2 2 1 | 5 2.0|
Hyperplasia, Lymphoid | 3 | 10 2.6|
Pigmentation | 2 3 | 4 2.3|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + | 40 |
Atrophy | | 1 3.0|
Ectasia | | 3 3.3|
Hematopoietic Cell Proliferation | 2 3 | 3 2.7|
Hemorrhage | 2 3 3 2 3 | 9 2.3|
Hyperplasia, Lymphoid | 2 2 3 | 10 2.4|
Pigmentation | | 2 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + | 40 |
Amyloid Deposition | | 1 3.0|
Hematopoietic Cell Proliferation | 4 3 1 4 4 1 4 3 1 1 3 | 26 2.6|
Pigmentation | 2 2 | 10 2.0|
Lymphoid Follicle, Atrophy | 3 3 | 6 2.7|
Lymphoid Follicle, Hyperplasia | 3 | 6 2.5|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + M + | 36 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 4| 5| 6| 5| 6| 6| 5| 6| 6| 6| 5| 6| | |
DAY ON TEST | 4| 6| 6| 1| 3| 6| 7| 7| 4| 6| 6| 1| 6| 1| 7| | |
| 6| 2| 7| 4| 0| 9| 2| 1| 1| 1| 8| 4| 9| 0| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
200 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L |
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Atrophy | 3 2 | 2 2.5|
Hyperplasia, Lymphoid | 2 3 | 7 2.7|
Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + | 40 |
Hyperplasia | 2 2 | 6 2.2|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + | 40 |
Cyst Epithelial Inclusion | | 1 |
Edema | 4 2 2 | 6 2.7|
Inflammation, Chronic | 2 | 1 2.0|
Ulcer | 3 | 5 3.0|
Epidermis, Hyperplasia | 2 | 4 2.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + | 40 |
Fibrous Osteodystrophy | 2 2 | 6 2.3|
Hyperostosis | | 1 3.0|
Myelofibrosis | | 1 3.0|
Femur, Hyperostosis | | 1 4.0|
|__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + | 5 |
Atrophy | | 1 2.0|
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 4| 5| 6| 5| 6| 6| 5| 6| 6| 6| 5| 6| | |
DAY ON TEST | 4| 6| 6| 1| 3| 6| 7| 7| 4| 6| 6| 1| 6| 1| 7| | |
| 6| 2| 7| 4| 0| 9| 2| 1| 1| 1| 8| 4| 9| 0| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
200 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L |
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
Cyst Epithelial Inclusion | | 1 |
Necrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + | 40 |
Edema | | 1 3.0|
Hemorrhage | | 2 2.0|
Hyperplasia, Lymphoid | 3 2 | 4 2.8|
Infiltration Cellular, Histiocyte | 4 3 4 | 12 3.4|
Infiltration Cellular, Mixed Cell | | 1 2.0|
Inflammation, Chronic | 2 | 2 2.5|
Alveolar Epithelium, Hyperplasia | 3 2 3 | 3 2.7|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + | 40 |
Inflammation, Chronic | | 2 1.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + | 40 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + | 1 |
Atrophy | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + | 40 |
Hyperplasia, Focal | 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + | 40 |
Cyst | X X | 7 |
Hydronephrosis | 3 4 | 5 2.8|
Infarct | | 2 3.0|
Infiltration Cellular, Mixed Cell | 2 2 3 3 2 | 14 2.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 4| 5| 6| 5| 6| 6| 5| 6| 6| 6| 5| 6| | |
DAY ON TEST | 4| 6| 6| 1| 3| 6| 7| 7| 4| 6| 6| 1| 6| 1| 7| | |
| 6| 2| 7| 4| 0| 9| 2| 1| 1| 1| 8| 4| 9| 0| 2| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
200 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| | L |
MG/KG/DY | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Nephropathy | 3 1 4 3 3 2 4 1 1 | 26 2.2|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | 4 | 3 3.3|
Renal Tubule, Dilatation | | 1 2.0|
Renal Tubule, Necrosis | 2 | 1 2.0|
Renal Tubule, Pigmentation | | 2 2.5|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + | 40 |
Hyperplasia, Lymphoid | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 6| 4| 2| 4| 5| 3| 6| 0| 6| 6| 5| 6| 6| 6| 5| 4| 4| 6| 5| 5| 4| 4| 4| 4| 5|
DAY ON TEST | 7| 7| 0| 1| 9| 3| 4| 4| 7| 7| 3| 7| 4| 6| 9| 8| 5| 7| 9| 8| 7| 6| 5| 8| 3|
| 8| 9| 7| 2| 3| 2| 5| 9| 7| 8| 0| 7| 1| 9| 3| 2| 5| 6| 8| 0| 4| 7| 3| 2| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
300 | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
MG/KG/DY | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + + A + + + + + + + + A + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + I + + + + + I + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + + + + M + + + + + + + + + + + +|
Edema | 2 3 2 3 2 2 |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 3 3|
Ulcer | |
Epithelium, Hyperplasia | 2 2 2 |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + + + + + + + + A + + + + + + + +|
Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + A + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Eosinophilic Focus | X |
Hematopoietic Cell Proliferation | 3 2 4 2 3 2 |
Infiltration Cellular, Mixed Cell | 2 2 2 2 2|
Necrosis, Focal | 2 1 |
Regeneration | |
Hepatocyte, Hypertrophy | 3 2|
Hepatocyte, Vacuolization Cytoplasmic| 3 3 |
Kupffer Cell, Hyperplasia | 2 2 |
Kupffer Cell, Pigmentation | 2 2 2 2 2|
|__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 4 4 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 55
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 6| 4| 2| 4| 5| 3| 6| 0| 6| 6| 5| 6| 6| 6| 5| 4| 4| 6| 5| 5| 4| 4| 4| 4| 5|
DAY ON TEST | 7| 7| 0| 1| 9| 3| 4| 4| 7| 7| 3| 7| 4| 6| 9| 8| 5| 7| 9| 8| 7| 6| 5| 8| 3|
| 8| 9| 7| 2| 3| 2| 5| 9| 7| 8| 0| 7| 1| 9| 3| 2| 5| 6| 8| 0| 4| 7| 3| 2| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
300 | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
MG/KG/DY | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Acinus, Cytoplasmic Alteration | 4 3 3|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 3 |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 3 |
Erosion | 2 |
Epithelium, Hyperplasia | 1 2 1 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 2 |
Infiltration Cellular, Mixed Cell | 1 |
Glands, Hyperplasia, Cystic | 2 3 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 2|
Inflammation, Chronic | 1 |
Mineralization | 2 3 |
Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 3 3 |
Hyperplasia, Diffuse | 2 |
Hypertrophy, Focal | |
Capsule, Hyperplasia | 3 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 2 2 2 2 2|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 56
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 6| 4| 2| 4| 5| 3| 6| 0| 6| 6| 5| 6| 6| 6| 5| 4| 4| 6| 5| 5| 4| 4| 4| 4| 5|
DAY ON TEST | 7| 7| 0| 1| 9| 3| 4| 4| 7| 7| 3| 7| 4| 6| 9| 8| 5| 7| 9| 8| 7| 6| 5| 8| 3|
| 8| 9| 7| 2| 3| 2| 5| 9| 7| 8| 0| 7| 1| 9| 3| 2| 5| 6| 8| 0| 4| 7| 3| 2| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
300 | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
MG/KG/DY | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Parathyroid Gland | + + + + + + + M + M + + + I + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis | |
Pars Distalis, Hyperplasia, Focal | 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 2 1 2 3 2 2 3 3 3 3 2 3 2 1 2|
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X X X |
Inflammation, Chronic | 2 2 2 2 3 3 4 4 4 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3|
Angiectasis | 4 2 4 |
Cyst | X X X X X X X X X X X X X X X X X |
Hemorrhage | |
Thrombosis | X |
Corpus Luteum, Hyperplasia | 2 |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Infiltration Cellular, Histiocyte | 3 |
Inflammation, Chronic | 3 |
Thrombosis | X |
Endometrium, Hyperplasia, Cystic | 2 2 2 2 2 3 2 3 3 3 2|
|__________________________________________________________________________|
Vagina | + + + + + + + + + + + + + + + + + + + M + + + + +|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 57
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 6| 4| 2| 4| 5| 3| 6| 0| 6| 6| 5| 6| 6| 6| 5| 4| 4| 6| 5| 5| 4| 4| 4| 4| 5|
DAY ON TEST | 7| 7| 0| 1| 9| 3| 4| 4| 7| 7| 3| 7| 4| 6| 9| 8| 5| 7| 9| 8| 7| 6| 5| 8| 3|
| 8| 9| 7| 2| 3| 2| 5| 9| 7| 8| 0| 7| 1| 9| 3| 2| 5| 6| 8| 0| 4| 7| 3| 2| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
300 | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
MG/KG/DY | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 3 2 2 3 4 4 3 2 4 4 4 4 3 |
Myelofibrosis | 3 |
|__________________________________________________________________________|
Lymph Node | + + + + + + + +|
Hyperplasia, Plasma Cell | 4 |
Pigmentation | 2|
Iliac, Hemorrhage | |
Inguinal, Hematopoietic Cell | |
Proliferation | 2 |
Inguinal, Hyperplasia, Lymphoid | 4 3 |
Lumbar, Hyperplasia, Lymphoid | |
Mediastinal, Hemorrhage | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 2 3 |
Ectasia | 4 4 |
Hematopoietic Cell Proliferation | 1 2 2 |
Hemorrhage | 1 3 2 1 3 |
Hyperplasia, Lymphoid | 2 2 |
Hyperplasia, Plasma Cell | 3 4 |
Pigmentation | 2 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 2 3 2 |
Ectasia | |
Hematopoietic Cell Proliferation | 2 2 2 2 2 |
Hemorrhage | 2 4 1 1 1 2 3 3|
Hyperplasia, Lymphoid | 3 3 2 2 |
Pigmentation | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 4 4 3 2 2 1 2 4 3 4 4 4 4 4 3|
Pigmentation | 2 3 2 2 3 2 3|
Lymphoid Follicle, Atrophy | 2 3 3 3 |
Lymphoid Follicle, Hyperplasia | 3 2 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 58
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 6| 4| 2| 4| 5| 3| 6| 0| 6| 6| 5| 6| 6| 6| 5| 4| 4| 6| 5| 5| 4| 4| 4| 4| 5|
DAY ON TEST | 7| 7| 0| 1| 9| 3| 4| 4| 7| 7| 3| 7| 4| 6| 9| 8| 5| 7| 9| 8| 7| 6| 5| 8| 3|
| 8| 9| 7| 2| 3| 2| 5| 9| 7| 8| 0| 7| 1| 9| 3| 2| 5| 6| 8| 0| 4| 7| 3| 2| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
300 | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
MG/KG/DY | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Atrophy | 4 3 2 2 |
Hemorrhage | 4 2 3 |
Hyperplasia, Lymphoid | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 2 2|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X X |
Edema | 3 3 3 4 |
Inflammation, Chronic | 4 |
Ulcer | 4 4 |
Epidermis, Hyperplasia | 4 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 3 1 3 3 |
Femur, Callus | |
|__________________________________________________________________________|
Skeletal Muscle | + + + |
Thrombosis | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + + + + + M + |
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 |
__________________________________________|__________________________________________________________________________|
Page 59
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 6| 4| 2| 4| 5| 3| 6| 0| 6| 6| 5| 6| 6| 6| 5| 4| 4| 6| 5| 5| 4| 4| 4| 4| 5|
DAY ON TEST | 7| 7| 0| 1| 9| 3| 4| 4| 7| 7| 3| 7| 4| 6| 9| 8| 5| 7| 9| 8| 7| 6| 5| 8| 3|
| 8| 9| 7| 2| 3| 2| 5| 9| 7| 8| 0| 7| 1| 9| 3| 2| 5| 6| 8| 0| 4| 7| 3| 2| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
300 | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6|
MG/KG/DY | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Edema | 4 1 3 |
Hemorrhage | 2 1 3 3 2 1|
Hyperplasia, Lymphoid | 2 |
Infiltration Cellular, Histiocyte | 3 1 2 2 4 3 2 |
Infiltration Cellular, Mixed Cell | |
Inflammation, Chronic | 3 4 |
Alveolar Epithelium, Hyperplasia | 2 2 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + |
Cataract | 3 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Hyperplasia, Focal | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 3 |
Cyst | X X X |
Hydronephrosis | 3 2 2 |
Infiltration Cellular, Mixed Cell | 2 3 2 2 3 2 2 2 2|
Metaplasia, Osseous | 2 |
Nephropathy | 4 4 3 1 3 4 1 1 1 4 1 4 2 2 1 4 1 3 4|
Renal Tubule, Accumulation, Hyaline | |
Droplet | 3 2 |
Renal Tubule, Pigmentation | 3 3 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 3 |
__________________________________________|__________________________________________________________________________
Page 60
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 0| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 3| 6| 6| 6| 6| | |
DAY ON TEST | 4| 6| 7| 7| 7| 8| 6| 6| 7| 6| 7| 7| 2| 6| 7| 7| 7| | |
| 3| 5| 1| 0| 0| 5| 9| 9| 2| 8| 2| 0| 5| 8| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
300 | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| | L |
MG/KG/DY | 8| 9| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + | 42 |
|__________________________________________________________________________|____________|
Gallbladder | + + M + + + + + + + + + + + + + + | 39 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + | 42 |
Edema | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + | 40 |
Edema | 1 3 | 8 2.3|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + | 42 |
Erosion | | 2 3.0|
Ulcer | 3 | 1 3.0|
Epithelium, Hyperplasia | 2 2 2 2 2 2 | 9 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + | 40 |
Epithelium, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + | 40 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + | 42 |
Basophilic Focus | X | 1 |
Eosinophilic Focus | X X | 3 |
Hematopoietic Cell Proliferation | 2 2 | 8 2.5|
Infiltration Cellular, Mixed Cell | 2 3 2 2 | 9 2.1|
Necrosis, Focal | 3 3 1 2 | 6 2.0|
Regeneration | 3 | 1 3.0|
Hepatocyte, Hypertrophy | | 2 2.5|
Hepatocyte, Vacuolization Cytoplasmic| | 2 3.0|
Kupffer Cell, Hyperplasia | | 2 2.0|
Kupffer Cell, Pigmentation | 2 | 6 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 0| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 3| 6| 6| 6| 6| | |
DAY ON TEST | 4| 6| 7| 7| 7| 8| 6| 6| 7| 6| 7| 7| 2| 6| 7| 7| 7| | |
| 3| 5| 1| 0| 0| 5| 9| 9| 2| 8| 2| 0| 5| 8| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
300 | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| | L |
MG/KG/DY | 8| 9| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Mesentery | + + | 5 |
Fat, Necrosis | 3 | 3 3.7|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + A + + + + | 41 |
Edema | | 1 2.0|
Acinus, Cytoplasmic Alteration | 3 | 4 3.3|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + | 42 |
Hyperplasia, Lymphoid | 2 2 | 4 2.3|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + | 42 |
Edema | 2 2 | 4 2.3|
Erosion | 1 | 2 1.5|
Epithelium, Hyperplasia | | 4 1.5|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + | 42 |
Edema | | 2 2.5|
Infiltration Cellular, Mixed Cell | | 1 1.0|
Glands, Hyperplasia, Cystic | 4 2 2 | 6 2.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + | 42 |
Cardiomyopathy | | 2 1.5|
Inflammation, Chronic | 3 | 2 2.0|
Mineralization | | 2 2.5|
Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + | 42 |
Accessory Adrenal Cortical Nodule | 3 3 3 3 | 6 3.0|
Hyperplasia, Diffuse | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 0| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 3| 6| 6| 6| 6| | |
DAY ON TEST | 4| 6| 7| 7| 7| 8| 6| 6| 7| 6| 7| 7| 2| 6| 7| 7| 7| | |
| 3| 5| 1| 0| 0| 5| 9| 9| 2| 8| 2| 0| 5| 8| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
300 | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| | L |
MG/KG/DY | 8| 9| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Hypertrophy, Focal | 3 | 1 3.0|
Capsule, Hyperplasia | | 2 2.5|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + | 42 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + A + + + + | 41 |
Hyperplasia | 1 2 2 2 | 10 1.8|
|__________________________________________________________________________|____________|
Parathyroid Gland | M + M + + + + + + M + + + + + + + | 36 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + | 42 |
Pars Distalis, Angiectasis | 3 2 | 2 2.5|
Pars Distalis, Hyperplasia, Focal | 1 3 2 | 4 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + | 42 |
Degeneration, Cystic | 3 3 3 3 3 3 2 3 1 2 3 2 2 | 29 2.4|
Follicular Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + | 42 |
Cyst | X X X X X | 12 |
Inflammation, Chronic | 4 3 3 2 2 2 3 | 16 2.8|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + | 42 |
Amyloid Deposition | | 1 3.0|
Angiectasis | 2 | 4 3.0|
Cyst | X X X X X X X X X X X X | 29 |
Hemorrhage | 3 3 2 3 | 4 2.8|
Thrombosis | | 1 |
Corpus Luteum, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 0| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 3| 6| 6| 6| 6| | |
DAY ON TEST | 4| 6| 7| 7| 7| 8| 6| 6| 7| 6| 7| 7| 2| 6| 7| 7| 7| | |
| 3| 5| 1| 0| 0| 5| 9| 9| 2| 8| 2| 0| 5| 8| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
300 | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| | L |
MG/KG/DY | 8| 9| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + | 42 |
Angiectasis | | 1 2.0|
Infiltration Cellular, Histiocyte | | 1 3.0|
Inflammation, Chronic | | 1 3.0|
Thrombosis | | 1 |
Endometrium, Hyperplasia, Cystic | 2 4 4 4 2 4 3 3 2 1 3 | 22 2.6|
|__________________________________________________________________________|____________|
Vagina | + + + + + + + + + + + + + + + + + | 41 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + | 42 |
Hyperplasia | 2 3 3 2 4 2 2 3 3 | 26 2.8|
Myelofibrosis | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + | 16 |
Hyperplasia, Plasma Cell | | 1 4.0|
Pigmentation | | 1 2.0|
Iliac, Hemorrhage | 3 | 1 3.0|
Inguinal, Hematopoietic Cell | | |
Proliferation | | 1 2.0|
Inguinal, Hyperplasia, Lymphoid | | 2 3.5|
Lumbar, Hyperplasia, Lymphoid | 3 | 1 3.0|
Mediastinal, Hemorrhage | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + | 42 |
Atrophy | | 4 2.5|
Ectasia | | 2 4.0|
Hematopoietic Cell Proliferation | 2 2 2 | 6 1.8|
Hemorrhage | 3 2 | 7 2.1|
Hyperplasia, Lymphoid | 2 2 | 4 2.0|
Hyperplasia, Plasma Cell | 4 | 3 3.7|
Pigmentation | 2 2 2 2 | 6 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 0| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 3| 6| 6| 6| 6| | |
DAY ON TEST | 4| 6| 7| 7| 7| 8| 6| 6| 7| 6| 7| 7| 2| 6| 7| 7| 7| | |
| 3| 5| 1| 0| 0| 5| 9| 9| 2| 8| 2| 0| 5| 8| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
300 | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| | L |
MG/KG/DY | 8| 9| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + | 42 |
Atrophy | | 5 2.4|
Ectasia | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 2 3 3 | 8 2.3|
Hemorrhage | 3 2 3 | 11 2.3|
Hyperplasia, Lymphoid | 2 3 3 | 7 2.6|
Pigmentation | 2 2 2 2 | 4 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + | 42 |
Hematopoietic Cell Proliferation | 1 3 3 3 3 3 3 3 4 2 3 3 | 29 3.0|
Pigmentation | 2 2 3 2 2 | 12 2.3|
Lymphoid Follicle, Atrophy | | 4 2.8|
Lymphoid Follicle, Hyperplasia | 2 2 2 2 2 | 7 2.1|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + | 42 |
Atrophy | | 4 2.8|
Hemorrhage | | 3 3.0|
Hyperplasia, Lymphoid | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + | 42 |
Hyperplasia | 2 1 1 | 7 1.9|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + | 42 |
Cyst Epithelial Inclusion | | 2 |
Edema | 3 | 5 3.2|
Inflammation, Chronic | | 1 4.0|
Ulcer | 3 | 3 3.7|
Epidermis, Hyperplasia | 4 | 3 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 0| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 3| 6| 6| 6| 6| | |
DAY ON TEST | 4| 6| 7| 7| 7| 8| 6| 6| 7| 6| 7| 7| 2| 6| 7| 7| 7| | |
| 3| 5| 1| 0| 0| 5| 9| 9| 2| 8| 2| 0| 5| 8| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
300 | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| | L |
MG/KG/DY | 8| 9| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
Bone | + + + + + + + + + + + + + + + + + | 42 |
Fibrous Osteodystrophy | | 4 2.5|
Femur, Callus | X | 1 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 4 |
Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + | 42 |
|__________________________________________________________________________|____________|
Peripheral Nerve | | 6 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + | 42 |
Cyst Epithelial Inclusion | | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + | 42 |
Amyloid Deposition | | 1 3.0|
Edema | | 3 2.7|
Hemorrhage | 3 2 | 8 2.1|
Hyperplasia, Lymphoid | | 1 2.0|
Infiltration Cellular, Histiocyte | 4 3 4 | 10 2.8|
Infiltration Cellular, Mixed Cell | 3 | 1 3.0|
Inflammation, Chronic | | 2 3.5|
Alveolar Epithelium, Hyperplasia | | 2 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + | 42 |
Inflammation, Chronic | 2 2 1 | 4 1.8|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + | 42 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 0| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 3| 6| 6| 6| 6| | |
DAY ON TEST | 4| 6| 7| 7| 7| 8| 6| 6| 7| 6| 7| 7| 2| 6| 7| 7| 7| | |
| 3| 5| 1| 0| 0| 5| 9| 9| 2| 8| 2| 0| 5| 8| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| | A |
300 | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| | L |
MG/KG/DY | 8| 9| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| | |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Eye | + M | 2 |
Cataract | | 1 3.0|
|__________________________________________________________________________|____________|
Harderian Gland | M + + + + + + + + + + + + + + + + | 41 |
Atrophy | | 1 3.0|
Hyperplasia, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + | 42 |
Amyloid Deposition | 3 | 2 3.0|
Cyst | X X | 5 |
Hydronephrosis | | 3 2.3|
Infiltration Cellular, Mixed Cell | 2 2 1 2 2 2 | 15 2.1|
Metaplasia, Osseous | 2 | 2 2.0|
Nephropathy | 3 3 1 1 1 1 1 2 3 1 2 2 1 1 | 33 2.2|
Renal Tubule, Accumulation, Hyaline | | |
Droplet | 3 | 3 2.7|
Renal Tubule, Pigmentation | | 2 3.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + | 42 |
Hyperplasia, Lymphoid | 2 | 3 2.3|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 6| 6| 6| 1| 3| 4| 5| 6| 6| 6| 4| 3| 6| 6| 6| 3| 3| 6| 6| 6| 6| 4| 1| 4| 6|
DAY ON TEST | 7| 7| 7| 1| 0| 5| 3| 2| 7| 1| 8| 9| 5| 7| 7| 2| 2| 0| 7| 7| 3| 1| 0| 9| 7|
| 8| 8| 8| 1| 8| 3| 8| 1| 6| 9| 6| 2| 4| 7| 5| 9| 9| 3| 8| 7| 5| 8| 4| 7| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
0 | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
MG/KG/DY | 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + I + + + + A + + + A + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + A + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + A + + +|
Edema | 2 2 2 2 2 |
Infiltration Cellular, Lymphocyte | |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + + + + + +|
Amyloid Deposition | |
Epithelium, Hyperplasia | 2 2 |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + + + +|
Amyloid Deposition | |
Epithelium, Hyperplasia | 2 2 |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + A + + +|
Amyloid Deposition | |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Basophilic Focus | X |
Clear Cell Focus | X |
Eosinophilic Focus | |
Hematopoietic Cell Proliferation | 1 3 2 1 2 2 2 |
Infiltration Cellular, Mixed Cell | 2 1 2 2|
Necrosis, Focal | 1 1 4 |
Centrilobular, Necrosis | |
Hepatocyte, Hypertrophy | 2 2 1 3 2 2 2 3 2 2 2|
Hepatocyte, Vacuolization Cytoplasmic| 2 |
Kupffer Cell, Hyperplasia | 3 3 |
Kupffer Cell, Pigmentation | 2 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 68
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 6| 6| 6| 1| 3| 4| 5| 6| 6| 6| 4| 3| 6| 6| 6| 3| 3| 6| 6| 6| 6| 4| 1| 4| 6|
DAY ON TEST | 7| 7| 7| 1| 0| 5| 3| 2| 7| 1| 8| 9| 5| 7| 7| 2| 2| 0| 7| 7| 3| 1| 0| 9| 7|
| 8| 8| 8| 1| 8| 3| 8| 1| 6| 9| 6| 2| 4| 7| 5| 9| 9| 3| 8| 7| 5| 8| 4| 7| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
0 | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
MG/KG/DY | 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Mesentery | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Acinus, Cytoplasmic Alteration | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Infiltration Cellular, Lymphoid | |
Infiltration Cellular, Mixed Cell | |
|__________________________________________________________________________|
Stomach, Forestomach | + A + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Ulcer | 2 |
Epithelium, Hyperplasia | 1|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + A + + +|
Erosion | 3 |
Glands, Hyperplasia, Cystic | 2 3 2 2 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + |
Inflammation, Chronic | 4 |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Cardiomyopathy | 2 2 2|
Inflammation, Chronic | |
Inflammation | 2 |
Thrombosis | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 3 3 3 3 |
Amyloid Deposition | |
Hyperplasia, Focal | |
__________________________________________|__________________________________________________________________________|
Page 69
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 6| 6| 6| 1| 3| 4| 5| 6| 6| 6| 4| 3| 6| 6| 6| 3| 3| 6| 6| 6| 6| 4| 1| 4| 6|
DAY ON TEST | 7| 7| 7| 1| 0| 5| 3| 2| 7| 1| 8| 9| 5| 7| 7| 2| 2| 0| 7| 7| 3| 1| 0| 9| 7|
| 8| 8| 8| 1| 8| 3| 8| 1| 6| 9| 6| 2| 4| 7| 5| 9| 9| 3| 8| 7| 5| 8| 4| 7| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
0 | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
MG/KG/DY | 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Hypertrophy, Focal | 2 |
Capsule, Hyperplasia | 3 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 1 3 3 4 |
|__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + I + + + + + + + + M + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Degeneration, Cystic | 2 3 3 2 2 2 2 2 3 3 2|
Follicular Cell, Hyperplasia | 1 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | 3|
Inflammation, Chronic | |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X |
Inflammation, Chronic | 4 4 2 4 2 3 2 |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 4 3 3 3 3 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Inflammation, Chronic | 3 3 |
__________________________________________|__________________________________________________________________________|
Page 70
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 6| 6| 6| 1| 3| 4| 5| 6| 6| 6| 4| 3| 6| 6| 6| 3| 3| 6| 6| 6| 6| 4| 1| 4| 6|
DAY ON TEST | 7| 7| 7| 1| 0| 5| 3| 2| 7| 1| 8| 9| 5| 7| 7| 2| 2| 0| 7| 7| 3| 1| 0| 9| 7|
| 8| 8| 8| 1| 8| 3| 8| 1| 6| 9| 6| 2| 4| 7| 5| 9| 9| 3| 8| 7| 5| 8| 4| 7| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
0 | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
MG/KG/DY | 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Atrophy | 1 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 4 3 4 4 4 4 2 2 3 4 2 2 4 2 4 4 2 3 4 3 4 4 4 4|
Infiltration Cellular, Mast Cell | 3 |
|__________________________________________________________________________|
Lymph Node | + + + + + + +|
Hematopoietic Cell Proliferation | 2 3 3 |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | 3 3 4 |
Inguinal, Hematopoietic Cell | |
Proliferation | |
Inguinal, Hyperplasia, Lymphoid | 1 3 |
Inguinal, Hyperplasia, Plasma Cell | 3 |
Mediastinal, Hemorrhage | |
Renal, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Plasma Cell | 3 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 4 |
Hematopoietic Cell Proliferation | 2 2 |
Hyperplasia, Lymphoid | 3 2 2 2 2 |
Hyperplasia, Plasma Cell | 3 4 3 3 3 3 3 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Ectasia | |
Hematopoietic Cell Proliferation | 2 2 3 3 2 3 2 |
Hemorrhage | 2 2 |
Hyperplasia, Lymphoid | 2 2 2 2 3 2 2 2 |
Infiltration Cellular, Histiocyte | 2 |
Necrosis | 3 |
Pigmentation | 2 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 71
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 6| 6| 6| 1| 3| 4| 5| 6| 6| 6| 4| 3| 6| 6| 6| 3| 3| 6| 6| 6| 6| 4| 1| 4| 6|
DAY ON TEST | 7| 7| 7| 1| 0| 5| 3| 2| 7| 1| 8| 9| 5| 7| 7| 2| 2| 0| 7| 7| 3| 1| 0| 9| 7|
| 8| 8| 8| 1| 8| 3| 8| 1| 6| 9| 6| 2| 4| 7| 5| 9| 9| 3| 8| 7| 5| 8| 4| 7| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
0 | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
MG/KG/DY | 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 3 4 4 4 1 4 4 4 4 4 4 4 3 3 3 3|
Pigmentation | |
Lymphoid Follicle, Atrophy | 3 4 3 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + M + + M + + + + + + + + + + + +|
Atrophy | 2 2 3 2 2 3 3 3|
Cyst | |
Hyperplasia, Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Ulcer | 4 4 4 4 4 4 4 4 2 4|
Epidermis, Hyperplasia | 1 3 4 4 4 4 4 2 4|
Epidermis, Inflammation | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + |
Hemorrhage | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + + + + |
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Infiltration Cellular, Mast Cell | 3 |
Necrosis | |
__________________________________________|__________________________________________________________________________|
Page 72
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 6| 6| 6| 1| 3| 4| 5| 6| 6| 6| 4| 3| 6| 6| 6| 3| 3| 6| 6| 6| 6| 4| 1| 4| 6|
DAY ON TEST | 7| 7| 7| 1| 0| 5| 3| 2| 7| 1| 8| 9| 5| 7| 7| 2| 2| 0| 7| 7| 3| 1| 0| 9| 7|
| 8| 8| 8| 1| 8| 3| 8| 1| 6| 9| 6| 2| 4| 7| 5| 9| 9| 3| 8| 7| 5| 8| 4| 7| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
0 | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
MG/KG/DY | 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Hemorrhage | 1 2 2 |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Histiocyte | 2 2 3 2 2 4 |
Inflammation, Chronic | 2 3 |
Thrombosis | X |
Alveolar Epithelium, Hyperplasia | 2 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Inflammation, Chronic | 3 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
Inflammation | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | |
Cyst | X X X X X X X X X X X X X X|
Hydronephrosis | 2 2 2 1 1 1 3 2 1 2 2 2 2 2 3 3 3 |
Infarct | 2 |
Infiltration Cellular, Mixed Cell | 2 2 2 2 2 2 |
Inflammation, Chronic | 2 |
Inflammation, Suppurative | 2 4 4 4 |
Metaplasia, Osseous | |
Nephropathy | 2 2 1 1 1 3 3 2 2 4 2 1 1 1 2 1 3 2|
Renal Tubule, Necrosis | 1 |
|__________________________________________________________________________|
Ureter | M |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 73
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 6| 6| 6| 1| 3| 4| 5| 6| 6| 6| 4| 3| 6| 6| 6| 3| 3| 6| 6| 6| 6| 4| 1| 4| 6|
DAY ON TEST | 7| 7| 7| 1| 0| 5| 3| 2| 7| 1| 8| 9| 5| 7| 7| 2| 2| 0| 7| 7| 3| 1| 0| 9| 7|
| 8| 8| 8| 1| 8| 3| 8| 1| 6| 9| 6| 2| 4| 7| 5| 9| 9| 3| 8| 7| 5| 8| 4| 7| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|
0 | 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|
MG/KG/DY | 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Urethra | |
Angiectasis | |
Inflammation, Chronic | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 3 3 |
Transitional Epithelium, Hyperplasia | 2 2 3 3 |
__________________________________________|__________________________________________________________________________
Page 74
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 5| 3| 6| 6| 5| 6| 4| 6| 6| 6| 6| 4| 3| 6| 5| 4| 5| 6| 6| 6| 6| 6| 4| 6| 4| |
DAY ON TEST | 6| 2| 6| 7| 6| 7| 1| 6| 7| 1| 0| 6| 7| 4| 6| 4| 3| 7| 7| 7| 6| 7| 7| 6| 8| |
| 5| 2| 8| 0| 0| 0| 3| 1| 2| 4| 1| 3| 3| 1| 7| 6| 2| 0| 1| 1| 8| 2| 5| 9| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| A |
0 | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 1| L |
MG/KG/DY | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 2| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + M A + + + + + + + + + + + +| 45 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + M + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + M + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Edema | 2 2 2 2 2 2 2 2 | 13 2.0|
Infiltration Cellular, Lymphocyte | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Amyloid Deposition | 2 | 1 2.0|
Epithelium, Hyperplasia | 3 | 3 2.3|
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Amyloid Deposition | 2 | 1 2.0|
Epithelium, Hyperplasia | 2 3 | 4 2.3|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Amyloid Deposition | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
Basophilic Focus | X | 2 |
Clear Cell Focus | | 1 |
Eosinophilic Focus | X X X | 3 |
Hematopoietic Cell Proliferation | 2 2 | 9 1.9|
Infiltration Cellular, Mixed Cell | 2 2 2 1 3 3 | 10 2.0|
Necrosis, Focal | 4 4 4 1 1 | 8 2.5|
Centrilobular, Necrosis | 3 1 | 2 2.0|
Hepatocyte, Hypertrophy | 3 2 2 2 | 15 2.1|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 5| 3| 6| 6| 5| 6| 4| 6| 6| 6| 6| 4| 3| 6| 5| 4| 5| 6| 6| 6| 6| 6| 4| 6| 4| |
DAY ON TEST | 6| 2| 6| 7| 6| 7| 1| 6| 7| 1| 0| 6| 7| 4| 6| 4| 3| 7| 7| 7| 6| 7| 7| 6| 8| |
| 5| 2| 8| 0| 0| 0| 3| 1| 2| 4| 1| 3| 3| 1| 7| 6| 2| 0| 1| 1| 8| 2| 5| 9| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| A |
0 | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 1| L |
MG/KG/DY | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 2| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Hepatocyte, Vacuolization Cytoplasmic| | 1 2.0|
Kupffer Cell, Hyperplasia | | 2 3.0|
Kupffer Cell, Pigmentation | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Mesentery | + | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3 | 1 3.0|
Acinus, Cytoplasmic Alteration | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 | 1 3.0|
Infiltration Cellular, Lymphoid | 2 | 1 2.0|
Infiltration Cellular, Mixed Cell | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Edema | | 1 2.0|
Ulcer | | 1 2.0|
Epithelium, Hyperplasia | 1 | 2 1.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Erosion | 2 | 2 2.5|
Glands, Hyperplasia, Cystic | 1 2 2 3 | 9 2.2|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | | 1 |
Inflammation, Chronic | | 1 4.0|
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition | 2 | 1 2.0|
Cardiomyopathy | 1 1 2 3 3 2 2 1 2 | 12 1.9|
Inflammation, Chronic | 1 | 1 1.0|
Inflammation | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 5| 3| 6| 6| 5| 6| 4| 6| 6| 6| 6| 4| 3| 6| 5| 4| 5| 6| 6| 6| 6| 6| 4| 6| 4| |
DAY ON TEST | 6| 2| 6| 7| 6| 7| 1| 6| 7| 1| 0| 6| 7| 4| 6| 4| 3| 7| 7| 7| 6| 7| 7| 6| 8| |
| 5| 2| 8| 0| 0| 0| 3| 1| 2| 4| 1| 3| 3| 1| 7| 6| 2| 0| 1| 1| 8| 2| 5| 9| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| A |
0 | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 1| L |
MG/KG/DY | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 2| |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
Thrombosis | | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 3 3 3 3 | 8 3.0|
Amyloid Deposition | 2 | 1 2.0|
Hyperplasia, Focal | 2 3 | 2 2.5|
Hypertrophy, Focal | 2 3 2 3 3 | 6 2.5|
Capsule, Hyperplasia | 2 | 2 2.5|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 1 2 2 1 1 2 2 | 15 1.9|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Pars Distalis, Cyst | | 1 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition | 2 | 1 2.0|
Degeneration, Cystic | 3 3 3 1 3 1 2 3 3 2 3 3 2 3 2 1 1 1 | 29 2.3|
Follicular Cell, Hyperplasia | | 3 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atypia Cellular | | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 77
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 5| 3| 6| 6| 5| 6| 4| 6| 6| 6| 6| 4| 3| 6| 5| 4| 5| 6| 6| 6| 6| 6| 4| 6| 4| |
DAY ON TEST | 6| 2| 6| 7| 6| 7| 1| 6| 7| 1| 0| 6| 7| 4| 6| 4| 3| 7| 7| 7| 6| 7| 7| 6| 8| |
| 5| 2| 8| 0| 0| 0| 3| 1| 2| 4| 1| 3| 3| 1| 7| 6| 2| 0| 1| 1| 8| 2| 5| 9| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| A |
0 | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 1| L |
MG/KG/DY | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 2| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Inflammation, Chronic | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X X X | 6 |
Inflammation, Chronic | 2 2 2 2 | 11 2.6|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 1 2 | 8 2.6|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 3 | 2 3.0|
Inflammation, Chronic | | 2 3.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Germinal Epithelium, Atrophy | 3 | 4 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 4 3 2 2 4 2 3 4 3 3 4 3 2 3 2 3 4| 43 3.2|
Infiltration Cellular, Mast Cell | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + + +| 12 |
Hematopoietic Cell Proliferation | | 3 2.7|
Hyperplasia, Lymphoid | | 1 2.0|
Hyperplasia, Plasma Cell | | 3 3.3|
Inguinal, Hematopoietic Cell | | |
Proliferation | 2 | 1 2.0|
Inguinal, Hyperplasia, Lymphoid | | 2 2.0|
Inguinal, Hyperplasia, Plasma Cell | 3 | 2 3.0|
Mediastinal, Hemorrhage | 2 | 1 2.0|
Renal, Hyperplasia, Lymphoid | 3 | 1 3.0|
Renal, Hyperplasia, Plasma Cell | | 1 3.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 5| 3| 6| 6| 5| 6| 4| 6| 6| 6| 6| 4| 3| 6| 5| 4| 5| 6| 6| 6| 6| 6| 4| 6| 4| |
DAY ON TEST | 6| 2| 6| 7| 6| 7| 1| 6| 7| 1| 0| 6| 7| 4| 6| 4| 3| 7| 7| 7| 6| 7| 7| 6| 8| |
| 5| 2| 8| 0| 0| 0| 3| 1| 2| 4| 1| 3| 3| 1| 7| 6| 2| 0| 1| 1| 8| 2| 5| 9| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| A |
0 | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 1| L |
MG/KG/DY | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 2| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 3 | 2 3.5|
Hematopoietic Cell Proliferation | 2 2 2 2 3 | 7 2.1|
Hyperplasia, Lymphoid | 2 2 2 2 3 2 | 11 2.2|
Hyperplasia, Plasma Cell | 2 3 2 3 | 11 2.9|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 2.0|
Ectasia | 3 3 | 2 3.0|
Hematopoietic Cell Proliferation | 2 2 2 3 3 | 12 2.4|
Hemorrhage | 3 2 3 3 1 | 7 2.3|
Hyperplasia, Lymphoid | 3 2 2 3 2 2 2 | 15 2.2|
Infiltration Cellular, Histiocyte | | 1 2.0|
Necrosis | | 1 3.0|
Pigmentation | | 1 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + M +| 49 |
Hematopoietic Cell Proliferation | 4 4 2 4 4 4 3 4 4 4 3 1 4| 31 3.4|
Pigmentation | 2 2 | 2 2.0|
Lymphoid Follicle, Atrophy | 3 | 4 3.3|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Atrophy | 2 3 2 3 2 4 3 | 15 2.6|
Cyst | X X | 2 |
Hyperplasia, Lymphoid | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 2 4 2 2 3 3 3 4 4| 10 2.9|
Ulcer | 4 4 4 4 | 14 3.9|
Epidermis, Hyperplasia | 4 4 4 3 | 13 3.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 5| 3| 6| 6| 5| 6| 4| 6| 6| 6| 6| 4| 3| 6| 5| 4| 5| 6| 6| 6| 6| 6| 4| 6| 4| |
DAY ON TEST | 6| 2| 6| 7| 6| 7| 1| 6| 7| 1| 0| 6| 7| 4| 6| 4| 3| 7| 7| 7| 6| 7| 7| 6| 8| |
| 5| 2| 8| 0| 0| 0| 3| 1| 2| 4| 1| 3| 3| 1| 7| 6| 2| 0| 1| 1| 8| 2| 5| 9| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| A |
0 | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 1| L |
MG/KG/DY | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 2| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Epidermis, Inflammation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Hemorrhage | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + + | 7 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | X | 1 |
Infiltration Cellular, Mast Cell | | 1 3.0|
Necrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 1 |
Hemorrhage | 1 2 | 5 1.6|
Hyperplasia, Lymphoid | 3 | 1 3.0|
Infiltration Cellular, Histiocyte | 1 2 4 2 2 1 | 12 2.3|
Inflammation, Chronic | | 2 2.5|
Thrombosis | | 1 |
Alveolar Epithelium, Hyperplasia | 2 2 1 1 | 6 1.5|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 1 |
Inflammation, Chronic | 1 3 2 2 | 5 2.2|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 5| 3| 6| 6| 5| 6| 4| 6| 6| 6| 6| 4| 3| 6| 5| 4| 5| 6| 6| 6| 6| 6| 4| 6| 4| |
DAY ON TEST | 6| 2| 6| 7| 6| 7| 1| 6| 7| 1| 0| 6| 7| 4| 6| 4| 3| 7| 7| 7| 6| 7| 7| 6| 8| |
| 5| 2| 8| 0| 0| 0| 3| 1| 2| 4| 1| 3| 3| 1| 7| 6| 2| 0| 1| 1| 8| 2| 5| 9| 8| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| A |
0 | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 1| L |
MG/KG/DY | 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 2| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 3 2 | 2 2.5|
Inflammation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Amyloid Deposition | 2 3 3 | 3 2.7|
Cyst | X X X X X X X X X X X X X | 27 |
Hydronephrosis | 2 2 2 3 2 2 2 2 2 1 3 3 2| 30 2.1|
Infarct | | 1 2.0|
Infiltration Cellular, Mixed Cell | 2 2 2 | 9 2.0|
Inflammation, Chronic | | 1 2.0|
Inflammation, Suppurative | | 4 3.5|
Metaplasia, Osseous | 2 | 1 2.0|
Nephropathy | 1 2 2 1 1 1 2 2 1 1 1 2 2 1 1 2 3 2 2 1 3 2| 40 1.8|
Renal Tubule, Necrosis | 2 1 | 3 1.3|
|__________________________________________________________________________|____________|
Ureter | | |
|__________________________________________________________________________|____________|
Urethra | + | 1 |
Angiectasis | 4 | 1 4.0|
Inflammation, Chronic | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 4 2.5|
Transitional Epithelium, Hyperplasia | | 4 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 81
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 6| 6| 4| 4| 6| 4| 6| 6| 6| 3| 6| 6| 6| 3| 2| 6| 5| 1| 5| 2| 6| 6| 5| 0| 1|
DAY ON TEST | 7| 7| 9| 1| 7| 3| 7| 7| 7| 2| 7| 7| 7| 2| 2| 7| 2| 4| 9| 5| 7| 7| 6| 4| 5|
| 8| 6| 5| 8| 8| 2| 9| 7| 7| 9| 9| 9| 8| 2| 9| 9| 3| 7| 2| 4| 9| 8| 7| 5| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
50 | 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
MG/KG/DY | 8| 9| 1| 2| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + A + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + A + + + + + + + + + + +|
Edema | 2 2 2 2 2 |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 2 2 |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X |
Clear Cell Focus | |
Eosinophilic Focus | X X |
Hematopoietic Cell Proliferation | 1 4 3 3|
Hemorrhage | |
Infiltration Cellular, Mixed Cell | 3 2 2 2 2 |
Necrosis, Focal | 2 3 4 2 4 |
Hepatocyte, Hypertrophy | 2 3 3 2 3 2 2 2 2 |
Hepatocyte, Vacuolization Cytoplasmic| 2 |
Kupffer Cell, Pigmentation | 3 |
|__________________________________________________________________________|
Mesentery | + |
Hemorrhage | 4 |
Fat, Necrosis | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 82
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 6| 6| 4| 4| 6| 4| 6| 6| 6| 3| 6| 6| 6| 3| 2| 6| 5| 1| 5| 2| 6| 6| 5| 0| 1|
DAY ON TEST | 7| 7| 9| 1| 7| 3| 7| 7| 7| 2| 7| 7| 7| 2| 2| 7| 2| 4| 9| 5| 7| 7| 6| 4| 5|
| 8| 6| 5| 8| 8| 2| 9| 7| 7| 9| 9| 9| 8| 2| 9| 9| 3| 7| 2| 4| 9| 8| 7| 5| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
50 | 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
MG/KG/DY | 8| 9| 1| 2| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Acinus, Cytoplasmic Alteration | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Erosion | 2 2 |
Glands, Hyperplasia, Cystic | 2 2 2 4 1 |
|__________________________________________________________________________|
Tooth | + |
Malformation | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 2 2 |
Inflammation, Chronic | 2|
Mineralization | 4 1 |
Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 3 3 3 3 3 3 3 |
Hyperplasia, Focal | 2 2 2 2 |
Hypertrophy, Focal | 3 |
Capsule, Hyperplasia | |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 1 1 2 4 |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 83
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 6| 6| 4| 4| 6| 4| 6| 6| 6| 3| 6| 6| 6| 3| 2| 6| 5| 1| 5| 2| 6| 6| 5| 0| 1|
DAY ON TEST | 7| 7| 9| 1| 7| 3| 7| 7| 7| 2| 7| 7| 7| 2| 2| 7| 2| 4| 9| 5| 7| 7| 6| 4| 5|
| 8| 6| 5| 8| 8| 2| 9| 7| 7| 9| 9| 9| 8| 2| 9| 9| 3| 7| 2| 4| 9| 8| 7| 5| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
50 | 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
MG/KG/DY | 8| 9| 1| 2| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
Pars Distalis, Cyst | X |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 2 3 2 1 1 3 3 1 3 1 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Coagulating Gland | + |
Bilateral, Dilatation | 4 |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | 2|
Granuloma Sperm | |
|__________________________________________________________________________|
Penis | + |
Inflammation, Chronic Active | 3 |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X |
Inflammation, Chronic | 2 2 4 2 2 |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 4 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 3 |
Inflammation, Chronic | 3 |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Atrophy | 3 2 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 84
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 6| 6| 4| 4| 6| 4| 6| 6| 6| 3| 6| 6| 6| 3| 2| 6| 5| 1| 5| 2| 6| 6| 5| 0| 1|
DAY ON TEST | 7| 7| 9| 1| 7| 3| 7| 7| 7| 2| 7| 7| 7| 2| 2| 7| 2| 4| 9| 5| 7| 7| 6| 4| 5|
| 8| 6| 5| 8| 8| 2| 9| 7| 7| 9| 9| 9| 8| 2| 9| 9| 3| 7| 2| 4| 9| 8| 7| 5| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
50 | 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
MG/KG/DY | 8| 9| 1| 2| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 4 3 3 4 2 2 4 4 2 3 2 2 4 3|
|__________________________________________________________________________|
Lymph Node | + + + + + |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Lymphoid | 4 |
Bronchial, Hyperplasia, Lymphoid | |
Inguinal, Hyperplasia, Lymphoid | 3 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 2 3 3 |
Hyperplasia, Plasma Cell | 3 3 3 2 |
Pigmentation | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 3 2 3 3 3 |
Hematopoietic Cell Proliferation | 2 3 |
Hemorrhage | 1 2 1 2 3 2 2 3 |
Hyperplasia, Lymphoid | 3 2 3 2 3 3 2 3|
Necrosis | 2|
Pigmentation | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 4 3 4 4 3 2 4 4 4 2 2 2 4 3|
Pigmentation | 2 |
Lymphoid Follicle, Atrophy | 3 3 2 |
Lymphoid Follicle, Hyperplasia | 2 2 |
|__________________________________________________________________________|
Thymus | + + + + I + + + + + M + + + + + + + + + + + + + +|
Atrophy | 3 3 2 3 3 3 3|
Cyst | |
Hyperplasia, Lymphoid | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 85
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 6| 6| 4| 4| 6| 4| 6| 6| 6| 3| 6| 6| 6| 3| 2| 6| 5| 1| 5| 2| 6| 6| 5| 0| 1|
DAY ON TEST | 7| 7| 9| 1| 7| 3| 7| 7| 7| 2| 7| 7| 7| 2| 2| 7| 2| 4| 9| 5| 7| 7| 6| 4| 5|
| 8| 6| 5| 8| 8| 2| 9| 7| 7| 9| 9| 9| 8| 2| 9| 9| 3| 7| 2| 4| 9| 8| 7| 5| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
50 | 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
MG/KG/DY | 8| 9| 1| 2| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
Cyst Epithelial Inclusion | |
Edema | 3 |
Ulcer | 4 4 4 4 3 |
Epidermis, Hyperplasia | 4 4 4 3 |
Subcutaneous Tissue, Edema | 4|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Osteopetrosis | 3 |
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 4 |
|__________________________________________________________________________|
Peripheral Nerve | |
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 |
Hemorrhage | 3 |
Infiltration Cellular, Histiocyte | 2 4 3 2 3 4 2 |
Inflammation, Chronic | 3 |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 3 2 2 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Chronic | 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 86
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 6| 6| 4| 4| 6| 4| 6| 6| 6| 3| 6| 6| 6| 3| 2| 6| 5| 1| 5| 2| 6| 6| 5| 0| 1|
DAY ON TEST | 7| 7| 9| 1| 7| 3| 7| 7| 7| 2| 7| 7| 7| 2| 2| 7| 2| 4| 9| 5| 7| 7| 6| 4| 5|
| 8| 6| 5| 8| 8| 2| 9| 7| 7| 9| 9| 9| 8| 2| 9| 9| 3| 7| 2| 4| 9| 8| 7| 5| 7|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|
50 | 1| 1| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
MG/KG/DY | 8| 9| 1| 2| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 6|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypertrophy, Focal | 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X X X X X X X X X |
Hydronephrosis | 3 3 3 3 4 3 4 3 2 |
Infiltration Cellular, Mixed Cell | 2 2 2 2 2 2 |
Inflammation, Chronic | 2 |
Metaplasia, Osseous | 2 |
Mineralization | 3 |
Nephropathy | 3 3 2 1 2 3 1 2 1 1 3 3 1 1 1 2 1 3 1 1|
Renal Tubule, Dilatation | 2 |
Renal Tubule, Pigmentation | |
|__________________________________________________________________________|
Ureter | + |
Dilatation | 2 |
|__________________________________________________________________________|
Urethra | + + |
Inflammation, Chronic | |
Bulbourethral Gland, Cyst | X |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Transitional Epithelium, Hyperplasia | |
__________________________________________|__________________________________________________________________________
Page 87
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 4| 6| 6| 6| 6| 6| 6| 3| 3| 3| 3| 6| 1| 4| 4| 6| 6| 4| 5| 5| 6| 5| 2| 6| 5| |
DAY ON TEST | 7| 4| 7| 6| 7| 7| 7| 8| 2| 6| 0| 7| 6| 4| 7| 7| 2| 6| 8| 8| 7| 9| 3| 6| 6| |
| 5| 0| 1| 8| 0| 1| 0| 5| 2| 3| 0| 2| 8| 4| 9| 1| 4| 7| 8| 0| 0| 5| 6| 8| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| 7| 7| 7| 7| A |
50 | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 2| 2| 2| 3| 3| 3| L |
MG/KG/DY | 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 3| 5| 6| 0| 2| 4| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + M + + + + + + + + + + + + + + M + + + + A + +| 46 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Edema | 2 2 2 3 3 2 | 11 2.2|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Hyperplasia | 2 2 | 4 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Epithelium, Hyperplasia | 3 | 2 2.5|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + A + +| 48 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Basophilic Focus | X X X | 4 |
Clear Cell Focus | X | 1 |
Eosinophilic Focus | | 2 |
Hematopoietic Cell Proliferation | 2 3 2 | 7 2.6|
Hemorrhage | 4 | 1 4.0|
Infiltration Cellular, Mixed Cell | 2 2 | 7 2.1|
Necrosis, Focal | 1 3 2 3 | 9 2.7|
Hepatocyte, Hypertrophy | 3 2 3 3 2 3 | 15 2.5|
Hepatocyte, Vacuolization Cytoplasmic| | 1 2.0|
Kupffer Cell, Pigmentation | 3 2 | 3 2.7|
|__________________________________________________________________________|____________|
Mesentery | + | 2 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 88
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 4| 6| 6| 6| 6| 6| 6| 3| 3| 3| 3| 6| 1| 4| 4| 6| 6| 4| 5| 5| 6| 5| 2| 6| 5| |
DAY ON TEST | 7| 4| 7| 6| 7| 7| 7| 8| 2| 6| 0| 7| 6| 4| 7| 7| 2| 6| 8| 8| 7| 9| 3| 6| 6| |
| 5| 0| 1| 8| 0| 1| 0| 5| 2| 3| 0| 2| 8| 4| 9| 1| 4| 7| 8| 0| 0| 5| 6| 8| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| 7| 7| 7| 7| A |
50 | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 2| 2| 2| 3| 3| 3| L |
MG/KG/DY | 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 3| 5| 6| 0| 2| 4| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Hemorrhage | | 1 4.0|
Fat, Necrosis | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Cytoplasmic Alteration | 4 3 | 2 3.5|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 2 | 1 2.0|
Erosion | | 2 2.0|
Glands, Hyperplasia, Cystic | 4 1 2 2 1 2 2 2 | 13 2.1|
|__________________________________________________________________________|____________|
Tooth | | 1 |
Malformation | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | | 1 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 3 1 1 2 | 7 2.0|
Inflammation, Chronic | 3 3 3 2 | 5 2.6|
Mineralization | | 2 2.5|
Thrombosis | X X X | 4 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 3 3 | 9 3.0|
Hyperplasia, Focal | 2 | 5 2.0|
Hypertrophy, Focal | 3 4 2 3 | 5 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 89
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 4| 6| 6| 6| 6| 6| 6| 3| 3| 3| 3| 6| 1| 4| 4| 6| 6| 4| 5| 5| 6| 5| 2| 6| 5| |
DAY ON TEST | 7| 4| 7| 6| 7| 7| 7| 8| 2| 6| 0| 7| 6| 4| 7| 7| 2| 6| 8| 8| 7| 9| 3| 6| 6| |
| 5| 0| 1| 8| 0| 1| 0| 5| 2| 3| 0| 2| 8| 4| 9| 1| 4| 7| 8| 0| 0| 5| 6| 8| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| 7| 7| 7| 7| A |
50 | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 2| 2| 2| 3| 3| 3| L |
MG/KG/DY | 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 3| 5| 6| 0| 2| 4| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Capsule, Hyperplasia | 3 3 | 2 3.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 1 2 2 2 3 2| 13 2.1|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Cyst | X | 2 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 2 1 3 2 2 1 2 3 3 2 | 23 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Coagulating Gland | + | 2 |
Bilateral, Dilatation | | 1 4.0|
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atypia Cellular | 3 2 | 3 2.3|
Granuloma Sperm | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Penis | + | 2 |
Inflammation, Chronic Active | 2 | 2 2.5|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X | 7 |
Inflammation, Chronic | 4 3 3 2 2 3 | 11 2.6|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 90
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 4| 6| 6| 6| 6| 6| 6| 3| 3| 3| 3| 6| 1| 4| 4| 6| 6| 4| 5| 5| 6| 5| 2| 6| 5| |
DAY ON TEST | 7| 4| 7| 6| 7| 7| 7| 8| 2| 6| 0| 7| 6| 4| 7| 7| 2| 6| 8| 8| 7| 9| 3| 6| 6| |
| 5| 0| 1| 8| 0| 1| 0| 5| 2| 3| 0| 2| 8| 4| 9| 1| 4| 7| 8| 0| 0| 5| 6| 8| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| 7| 7| 7| 7| A |
50 | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 2| 2| 2| 3| 3| 3| L |
MG/KG/DY | 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 3| 5| 6| 0| 2| 4| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 2 | 3 2.7|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration | | 1 3.0|
Inflammation, Chronic | 2 3 | 3 2.7|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Germinal Epithelium, Atrophy | 1 2 2 2| 7 2.1|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 4 3 4 4 4 3 2 2 3 4 4 3 3 2 | 29 3.1|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + | 10 |
Hematopoietic Cell Proliferation | 2 | 2 2.5|
Hyperplasia, Lymphoid | 3 4 | 3 3.7|
Bronchial, Hyperplasia, Lymphoid | 3 | 1 3.0|
Inguinal, Hyperplasia, Lymphoid | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Lymphoid | 3 3 4 | 7 3.0|
Hyperplasia, Plasma Cell | 3 3 4 3 3 | 9 3.0|
Pigmentation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + A + + + + + + + + + + + + + +| 49 |
Ectasia | 3 3 | 7 2.9|
Hematopoietic Cell Proliferation | 3 | 3 2.7|
Hemorrhage | 1 1 3 2 2 2 | 14 1.9|
Hyperplasia, Lymphoid | 3 3 2 2 3 2 3 2 | 16 2.6|
Necrosis | | 1 2.0|
Pigmentation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 91
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 4| 6| 6| 6| 6| 6| 6| 3| 3| 3| 3| 6| 1| 4| 4| 6| 6| 4| 5| 5| 6| 5| 2| 6| 5| |
DAY ON TEST | 7| 4| 7| 6| 7| 7| 7| 8| 2| 6| 0| 7| 6| 4| 7| 7| 2| 6| 8| 8| 7| 9| 3| 6| 6| |
| 5| 0| 1| 8| 0| 1| 0| 5| 2| 3| 0| 2| 8| 4| 9| 1| 4| 7| 8| 0| 0| 5| 6| 8| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| 7| 7| 7| 7| A |
50 | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 2| 2| 2| 3| 3| 3| L |
MG/KG/DY | 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 3| 5| 6| 0| 2| 4| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 3 2 1 1 4 4 4 2 4 3 4 3 3 | 29 3.0|
Pigmentation | 2 2 | 3 2.0|
Lymphoid Follicle, Atrophy | 2 3| 5 2.6|
Lymphoid Follicle, Hyperplasia | 2 2 2 2 | 6 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + M + + + + + + + M + + + M + + + + +| 45 |
Atrophy | 2 4 2 4 3 | 12 2.9|
Cyst | X | 1 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | X X | 2 |
Edema | 3 | 2 3.0|
Ulcer | 4 3 4 4 4 4 1 4 4 | 14 3.6|
Epidermis, Hyperplasia | 3 3 4 3 3 1 3 2 | 12 3.1|
Subcutaneous Tissue, Edema | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Femur, Osteopetrosis | | 1 3.0|
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrocephalus | | 1 4.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 92
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 4| 6| 6| 6| 6| 6| 6| 3| 3| 3| 3| 6| 1| 4| 4| 6| 6| 4| 5| 5| 6| 5| 2| 6| 5| |
DAY ON TEST | 7| 4| 7| 6| 7| 7| 7| 8| 2| 6| 0| 7| 6| 4| 7| 7| 2| 6| 8| 8| 7| 9| 3| 6| 6| |
| 5| 0| 1| 8| 0| 1| 0| 5| 2| 3| 0| 2| 8| 4| 9| 1| 4| 7| 8| 0| 0| 5| 6| 8| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| 7| 7| 7| 7| A |
50 | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 2| 2| 2| 3| 3| 3| L |
MG/KG/DY | 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 3| 5| 6| 0| 2| 4| |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
Peripheral Nerve | + + + + | 4 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 1 3.0|
Hemorrhage | 2 1 | 3 2.0|
Infiltration Cellular, Histiocyte | 4 2 4 2 4 4 1 4 2| 16 2.9|
Inflammation, Chronic | | 1 3.0|
Thrombosis | X | 1 |
Alveolar Epithelium, Hyperplasia | | 3 2.3|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | X | 1 |
Inflammation, Chronic | 2 1 2 3 | 5 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | | 1 |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypertrophy, Focal | | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X X X X X X X X X | 23 |
Hydronephrosis | 2 3 3 3 3 2 3 4 3 2 4 | 20 3.0|
Infiltration Cellular, Mixed Cell | 2 2 2 3 2 | 11 2.1|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 93
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 4| 6| 6| 6| 6| 6| 6| 3| 3| 3| 3| 6| 1| 4| 4| 6| 6| 4| 5| 5| 6| 5| 2| 6| 5| |
DAY ON TEST | 7| 4| 7| 6| 7| 7| 7| 8| 2| 6| 0| 7| 6| 4| 7| 7| 2| 6| 8| 8| 7| 9| 3| 6| 6| |
| 5| 0| 1| 8| 0| 1| 0| 5| 2| 3| 0| 2| 8| 4| 9| 1| 4| 7| 8| 0| 0| 5| 6| 8| 2| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| 7| 7| 7| 7| A |
50 | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 2| 2| 2| 3| 3| 3| L |
MG/KG/DY | 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 3| 5| 6| 0| 2| 4| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Inflammation, Chronic | 2 | 2 2.0|
Metaplasia, Osseous | | 1 2.0|
Mineralization | | 1 3.0|
Nephropathy | 1 1 2 1 1 3 1 2 1 1 2 3 3 1 2 3 2 2 2 1| 40 1.8|
Renal Tubule, Dilatation | | 1 2.0|
Renal Tubule, Pigmentation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Ureter | + + | 3 |
Dilatation | 3 | 2 2.5|
|__________________________________________________________________________|____________|
Urethra | + +| 4 |
Inflammation, Chronic | 3 | 1 3.0|
Bulbourethral Gland, Cyst | | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Transitional Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 94
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 5| 6| 3| 6| 5| 6| 3| 4| 6| 2| 6| 6| 4| 4| 4| 6| 5| 6| 6| 5| 5| 6| 4| 6| 6|
DAY ON TEST | 9| 7| 0| 0| 3| 4| 2| 8| 5| 4| 7| 7| 8| 8| 7| 3| 3| 7| 0| 0| 4| 0| 9| 6| 7|
| 8| 5| 8| 7| 6| 8| 0| 1| 1| 3| 8| 5| 9| 2| 4| 1| 8| 8| 8| 5| 4| 6| 0| 8| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|
100 | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6|
MG/KG/DY | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + M + + + + + + + M + + + + + A + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + M + + + + + + + + + + + + + + + +|
Edema | 2 |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + A + + + + +|
Edema | 3 2 2 |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + A + + + + +|
Epithelium, Hyperplasia | 3 |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + M A + + M + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Cholangiofibrosis | 4 |
Cyst | |
Eosinophilic Focus | X X |
Hematopoietic Cell Proliferation | 2 4 4 3 2 3 3 2 |
Hemorrhage | 3 |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Mixed Cell | 2 2 |
Necrosis, Focal | 4 4 4 2 3 2 |
Regeneration | |
Tension Lipidosis | X |
Centrilobular, Necrosis | 2 |
Hepatocyte, Hypertrophy | 3 2 3 2 2 |
Hepatocyte, Vacuolization Cytoplasmic| 3 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
__________________________________________|__________________________________________________________________________|
Page 95
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 5| 6| 3| 6| 5| 6| 3| 4| 6| 2| 6| 6| 4| 4| 4| 6| 5| 6| 6| 5| 5| 6| 4| 6| 6|
DAY ON TEST | 9| 7| 0| 0| 3| 4| 2| 8| 5| 4| 7| 7| 8| 8| 7| 3| 3| 7| 0| 0| 4| 0| 9| 6| 7|
| 8| 5| 8| 7| 6| 8| 0| 1| 1| 3| 8| 5| 9| 2| 4| 1| 8| 8| 8| 5| 4| 6| 0| 8| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|
100 | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6|
MG/KG/DY | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Edema | 2 |
Acinus, Cytoplasmic Alteration | 3 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mixed Cell | 2 |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 2 |
Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 2 |
Erosion | |
Glands, Hyperplasia, Cystic | 2 3 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 1 2 1 1 1 2 2 1 2 3 |
Inflammation, Chronic | 3 2 |
Mineralization | |
Thrombosis | X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 3 3 3 3 |
Hyperplasia, Focal | 2 2 2 |
Hypertrophy, Focal | 2 3 |
Capsule, Hyperplasia | 3 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 3 2 2 3 3 |
__________________________________________|__________________________________________________________________________|
Page 96
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 5| 6| 3| 6| 5| 6| 3| 4| 6| 2| 6| 6| 4| 4| 4| 6| 5| 6| 6| 5| 5| 6| 4| 6| 6|
DAY ON TEST | 9| 7| 0| 0| 3| 4| 2| 8| 5| 4| 7| 7| 8| 8| 7| 3| 3| 7| 0| 0| 4| 0| 9| 6| 7|
| 8| 5| 8| 7| 6| 8| 0| 1| 1| 3| 8| 5| 9| 2| 4| 1| 8| 8| 8| 5| 4| 6| 0| 8| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|
100 | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6|
MG/KG/DY | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + M + + + + + M +|
|__________________________________________________________________________|
Pituitary Gland | + + + M + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 3 2 2 2 3 2 2 3 2 2 4 3 3 2 1 3 3 2 2|
Follicular Cell, Hyperplasia | 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Coagulating Gland | + |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | |
Inflammation, Chronic | |
Spermatocele | 2 3 |
|__________________________________________________________________________|
Penis | + |
Inflammation, Chronic Active | 2 |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
Inflammation, Chronic | 4 4 3 3 2 2 2 4 4|
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 2 2 1 1 2|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Atrophy | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 97
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 5| 6| 3| 6| 5| 6| 3| 4| 6| 2| 6| 6| 4| 4| 4| 6| 5| 6| 6| 5| 5| 6| 4| 6| 6|
DAY ON TEST | 9| 7| 0| 0| 3| 4| 2| 8| 5| 4| 7| 7| 8| 8| 7| 3| 3| 7| 0| 0| 4| 0| 9| 6| 7|
| 8| 5| 8| 7| 6| 8| 0| 1| 1| 3| 8| 5| 9| 2| 4| 1| 8| 8| 8| 5| 4| 6| 0| 8| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|
100 | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6|
MG/KG/DY | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 4 2 2 3 4 4 4 2 4 2 2 4 4 3 2 3 4 3|
|__________________________________________________________________________|
Lymph Node | + + + + + + + |
Hematopoietic Cell Proliferation | 3 |
Hyperplasia, Lymphoid | 3 |
Iliac, Hyperplasia, Lymphoid | 4 |
Iliac, Pigmentation | |
Inguinal, Hematopoietic Cell | |
Proliferation | 3 |
Inguinal, Hyperplasia, Lymphoid | 2 3 4 4 |
Inguinal, Pigmentation | |
Lumbar, Pigmentation | |
Mediastinal, Hyperplasia, Lymphoid | 3 4 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + I + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Ectasia | 3 |
Hematopoietic Cell Proliferation | 3 2 2 |
Hemorrhage | 1 |
Hyperplasia, Lymphoid | 3 3 3 3 2 |
Hyperplasia, Plasma Cell | 2 |
Pigmentation | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Ectasia | 3 2 |
Hematopoietic Cell Proliferation | 3 3 2 3 2 |
Hemorrhage | 4 3 3 2 1 3 3 2 1 2 1 3 |
Hyperplasia, Lymphoid | 2 2 3 3 2 2 2 |
Necrosis | 2 3 |
Pigmentation | 2 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 2 4 2 2 3 4 4 4 4 2 4 2 2 2 4 1|
Pigmentation | |
Lymphoid Follicle, Atrophy | 2 3 2 3 |
__________________________________________|__________________________________________________________________________|
Page 98
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 5| 6| 3| 6| 5| 6| 3| 4| 6| 2| 6| 6| 4| 4| 4| 6| 5| 6| 6| 5| 5| 6| 4| 6| 6|
DAY ON TEST | 9| 7| 0| 0| 3| 4| 2| 8| 5| 4| 7| 7| 8| 8| 7| 3| 3| 7| 0| 0| 4| 0| 9| 6| 7|
| 8| 5| 8| 7| 6| 8| 0| 1| 1| 3| 8| 5| 9| 2| 4| 1| 8| 8| 8| 5| 4| 6| 0| 8| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|
100 | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6|
MG/KG/DY | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Lymphoid Follicle, Hyperplasia | |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + M + + + + + + + + + +|
Atrophy | 3 2 3 2 3 3 2 3 3 |
Cyst | |
Hyperplasia, Lymphoid | 3 3 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 4 3 2 2 2 |
Ulcer | 4 4 4 4 3 4 |
Epidermis, Hyperplasia | 3 4 4 3 3 |
Epidermis, Inflammation | 4 |
Epidermis, Ulcer | 4 |
Subcutaneous Tissue, Edema | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
|__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + + + + |
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 4 |
__________________________________________|__________________________________________________________________________|
Page 99
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 5| 6| 3| 6| 5| 6| 3| 4| 6| 2| 6| 6| 4| 4| 4| 6| 5| 6| 6| 5| 5| 6| 4| 6| 6|
DAY ON TEST | 9| 7| 0| 0| 3| 4| 2| 8| 5| 4| 7| 7| 8| 8| 7| 3| 3| 7| 0| 0| 4| 0| 9| 6| 7|
| 8| 5| 8| 7| 6| 8| 0| 1| 1| 3| 8| 5| 9| 2| 4| 1| 8| 8| 8| 5| 4| 6| 0| 8| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|
100 | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6|
MG/KG/DY | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Fibrosis, Focal | |
Foreign Body | X |
Hemorrhage | 3 3 3 2 3 |
Infiltration Cellular, Histiocyte | 3 3 2 3 4 4 4 |
Inflammation, Chronic | 4 3 2 3 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Inflammation, Chronic | 2 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X X X X X X |
Hydronephrosis | 4 3 2 2 3 3 3 2 3 2 |
Infiltration Cellular, Mixed Cell | 2 2 3 2 3 2 3 3 2 |
Inflammation, Chronic | 3 |
Metaplasia, Osseous | |
Nephropathy | 2 2 3 2 3 1 2 1 2 1 1 1 2 2 2 3 1 4 1 1 1|
Renal Tubule, Dilatation | 3 2 2 |
Renal Tubule, Pigmentation | 3 3 |
|__________________________________________________________________________|
Ureter | |
Dilatation | |
|__________________________________________________________________________|
Urethra | + |
Angiectasis | 4 |
Inflammation, Chronic | 3 |
Bulbourethral Gland, Cyst | |
__________________________________________|__________________________________________________________________________|
Page 100
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 5| 6| 3| 6| 5| 6| 3| 4| 6| 2| 6| 6| 4| 4| 4| 6| 5| 6| 6| 5| 5| 6| 4| 6| 6|
DAY ON TEST | 9| 7| 0| 0| 3| 4| 2| 8| 5| 4| 7| 7| 8| 8| 7| 3| 3| 7| 0| 0| 4| 0| 9| 6| 7|
| 8| 5| 8| 7| 6| 8| 0| 1| 1| 3| 8| 5| 9| 2| 4| 1| 8| 8| 8| 5| 4| 6| 0| 8| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|
100 | 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6|
MG/KG/DY | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Hemorrhage | 2 2 |
Inflammation, Chronic | 2 |
Transitional Epithelium, Hyperplasia | |
__________________________________________|__________________________________________________________________________
Page 101
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 1| 6| 6| 1| 5| 3| 6| 5| 2| 6| 2| 5| 5| 6| 6| 6| 4| 3| 3| 5| 3| 4| |
DAY ON TEST | 6| 7| 6| 4| 7| 3| 8| 3| 7| 7| 1| 2| 7| 1| 4| 7| 7| 2| 0| 1| 1| 2| 6| 7| 3| |
| 8| 2| 9| 7| 0| 3| 7| 2| 6| 1| 0| 9| 1| 4| 6| 0| 0| 7| 5| 3| 5| 2| 7| 6| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| A |
100 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 2| 2| L |
MG/KG/DY | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 7| 8| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + + A + + + + + + + + + + + + + + + + + +| 46 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Edema | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + M + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + M + + + + + + + + + + +| 48 |
Edema | 2 2 2 2 3 | 8 2.3|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Epithelium, Hyperplasia | 3 2 2 | 4 2.5|
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + A + + + + + + + + A + + + + + + + A M| 46 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X | 2 |
Cholangiofibrosis | | 1 4.0|
Cyst | X X | 2 |
Eosinophilic Focus | | 2 |
Hematopoietic Cell Proliferation | 2 3 3 1 | 12 2.7|
Hemorrhage | | 1 3.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Infiltration Cellular, Mixed Cell | | 2 2.0|
Necrosis, Focal | 2 | 7 3.0|
Regeneration | X | 1 |
Tension Lipidosis | | 1 |
Centrilobular, Necrosis | | 1 2.0|
Hepatocyte, Hypertrophy | 2 2 2 3 | 9 2.3|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 102
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 1| 6| 6| 1| 5| 3| 6| 5| 2| 6| 2| 5| 5| 6| 6| 6| 4| 3| 3| 5| 3| 4| |
DAY ON TEST | 6| 7| 6| 4| 7| 3| 8| 3| 7| 7| 1| 2| 7| 1| 4| 7| 7| 2| 0| 1| 1| 2| 6| 7| 3| |
| 8| 2| 9| 7| 0| 3| 7| 2| 6| 1| 0| 9| 1| 4| 6| 0| 0| 7| 5| 3| 5| 2| 7| 6| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| A |
100 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 2| 2| L |
MG/KG/DY | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 7| 8| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Hepatocyte, Vacuolization Cytoplasmic| 3 | 2 3.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 4.0|
Edema | 2 | 2 2.0|
Acinus, Cytoplasmic Alteration | | 1 3.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mixed Cell | | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 2 2.0|
Epithelium, Hyperplasia | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | | 2 2.0|
Erosion | 3 | 1 3.0|
Glands, Hyperplasia, Cystic | 4 2 2 3 2 3 2 | 10 2.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + | 1 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 2 1 2 1 2 | 19 1.6|
Inflammation, Chronic | 2 | 3 2.3|
Mineralization | 1| 1 1.0|
Thrombosis | X X | 5 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | 3 3 3 | 7 3.0|
Hyperplasia, Focal | | 3 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 103
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 1| 6| 6| 1| 5| 3| 6| 5| 2| 6| 2| 5| 5| 6| 6| 6| 4| 3| 3| 5| 3| 4| |
DAY ON TEST | 6| 7| 6| 4| 7| 3| 8| 3| 7| 7| 1| 2| 7| 1| 4| 7| 7| 2| 0| 1| 1| 2| 6| 7| 3| |
| 8| 2| 9| 7| 0| 3| 7| 2| 6| 1| 0| 9| 1| 4| 6| 0| 0| 7| 5| 3| 5| 2| 7| 6| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| A |
100 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 2| 2| L |
MG/KG/DY | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 7| 8| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Hypertrophy, Focal | 2 2 | 4 2.3|
Capsule, Hyperplasia | | 1 3.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + I + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 1 1.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 2 2 1 1| 12 2.2|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Cyst | X X | 3 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic | 3 2 3 2 2 3 1 2 3 2 2 1 3| 33 2.3|
Follicular Cell, Hyperplasia | | 2 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Coagulating Gland | + | 2 |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atypia Cellular | 2 2 3 | 3 2.3|
Inflammation, Chronic | 3 | 1 3.0|
Spermatocele | | 2 2.5|
|__________________________________________________________________________|____________|
Penis | | 1 |
Inflammation, Chronic Active | | 1 2.0|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 104
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 1| 6| 6| 1| 5| 3| 6| 5| 2| 6| 2| 5| 5| 6| 6| 6| 4| 3| 3| 5| 3| 4| |
DAY ON TEST | 6| 7| 6| 4| 7| 3| 8| 3| 7| 7| 1| 2| 7| 1| 4| 7| 7| 2| 0| 1| 1| 2| 6| 7| 3| |
| 8| 2| 9| 7| 0| 3| 7| 2| 6| 1| 0| 9| 1| 4| 6| 0| 0| 7| 5| 3| 5| 2| 7| 6| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| A |
100 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 2| 2| L |
MG/KG/DY | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 7| 8| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Cyst | X X X | 6 |
Inflammation, Chronic | 2 3 4 2 2 3 4 4 4 | 18 3.1|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | 3 2 3 2 2 3| 12 2.1|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Germinal Epithelium, Atrophy | 3 2 2 2 | 5 2.4|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 3 3 2 3 4 4 4 4 2 2 4 2 2 4 4 | 35 3.1|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + +| 15 |
Hematopoietic Cell Proliferation | | 1 3.0|
Hyperplasia, Lymphoid | 3 | 2 3.0|
Iliac, Hyperplasia, Lymphoid | | 1 4.0|
Iliac, Pigmentation | 3 | 1 3.0|
Inguinal, Hematopoietic Cell | | |
Proliferation | | 1 3.0|
Inguinal, Hyperplasia, Lymphoid | 4 4 | 6 3.5|
Inguinal, Pigmentation | 2 | 1 2.0|
Lumbar, Pigmentation | 2 | 1 2.0|
Mediastinal, Hyperplasia, Lymphoid | 3 | 3 3.3|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 2 | 1 2.0|
Ectasia | | 1 3.0|
Hematopoietic Cell Proliferation | 2 2 4 | 6 2.5|
Hemorrhage | 2 2 | 3 1.7|
Hyperplasia, Lymphoid | 2 2 3 3 | 9 2.7|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 105
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 1| 6| 6| 1| 5| 3| 6| 5| 2| 6| 2| 5| 5| 6| 6| 6| 4| 3| 3| 5| 3| 4| |
DAY ON TEST | 6| 7| 6| 4| 7| 3| 8| 3| 7| 7| 1| 2| 7| 1| 4| 7| 7| 2| 0| 1| 1| 2| 6| 7| 3| |
| 8| 2| 9| 7| 0| 3| 7| 2| 6| 1| 0| 9| 1| 4| 6| 0| 0| 7| 5| 3| 5| 2| 7| 6| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| A |
100 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 2| 2| L |
MG/KG/DY | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 7| 8| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Hyperplasia, Plasma Cell | 2 3 4 3 3 | 6 2.8|
Pigmentation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 |
Atrophy | 3 | 2 3.0|
Ectasia | 2 | 3 2.3|
Hematopoietic Cell Proliferation | 2 3 3 | 8 2.6|
Hemorrhage | 3 4 3 2 3 | 17 2.5|
Hyperplasia, Lymphoid | 2 2 | 9 2.2|
Necrosis | 3 | 3 2.7|
Pigmentation | | 1 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 1 2 3 3 4 4 3 3 4 3 | 27 3.0|
Pigmentation | 2 2 2 2 | 4 2.0|
Lymphoid Follicle, Atrophy | 3 | 5 2.6|
Lymphoid Follicle, Hyperplasia | 3 3 2 2 2 | 5 2.4|
|__________________________________________________________________________|____________|
Thymus | + + + M + + + + + M + + + + + + + + + + + + + + +| 47 |
Atrophy | 2 3 3 3 3 3 | 15 2.7|
Cyst | X X | 2 |
Hyperplasia, Lymphoid | 3 3 2 | 6 2.7|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 2 2 | 7 2.4|
Ulcer | 3 4 3 4 4 4 4 | 13 3.8|
Epidermis, Hyperplasia | 4 3 3 4 4 2 4 | 12 3.4|
Epidermis, Inflammation | | 1 4.0|
Epidermis, Ulcer | | 1 4.0|
Subcutaneous Tissue, Edema | 3 | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 106
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 1| 6| 6| 1| 5| 3| 6| 5| 2| 6| 2| 5| 5| 6| 6| 6| 4| 3| 3| 5| 3| 4| |
DAY ON TEST | 6| 7| 6| 4| 7| 3| 8| 3| 7| 7| 1| 2| 7| 1| 4| 7| 7| 2| 0| 1| 1| 2| 6| 7| 3| |
| 8| 2| 9| 7| 0| 3| 7| 2| 6| 1| 0| 9| 1| 4| 6| 0| 0| 7| 5| 3| 5| 2| 7| 6| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| A |
100 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 2| 2| L |
MG/KG/DY | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 7| 8| |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + +| 7 |
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 2 | 2 3.0|
Fibrosis, Focal | 3 | 1 3.0|
Foreign Body | | 1 |
Hemorrhage | 2 1 | 7 2.4|
Infiltration Cellular, Histiocyte | 2 2 2 2 1 4 | 13 2.8|
Inflammation, Chronic | 3 | 5 3.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | | 1 |
Inflammation, Chronic | 2 1 2 | 5 1.8|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | | 1 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 107
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 6| 6| 6| 1| 6| 6| 1| 5| 3| 6| 5| 2| 6| 2| 5| 5| 6| 6| 6| 4| 3| 3| 5| 3| 4| |
DAY ON TEST | 6| 7| 6| 4| 7| 3| 8| 3| 7| 7| 1| 2| 7| 1| 4| 7| 7| 2| 0| 1| 1| 2| 6| 7| 3| |
| 8| 2| 9| 7| 0| 3| 7| 2| 6| 1| 0| 9| 1| 4| 6| 0| 0| 7| 5| 3| 5| 2| 7| 6| 4| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 7| A |
100 | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 2| 2| L |
MG/KG/DY | 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 7| 8| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
Harderian Gland | + + + + + + + + + + + + + + + + + + M + + + + + +| 49 |
Hyperplasia, Focal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X X X X X X X X X X X X X X X| 26 |
Hydronephrosis | 3 4 4 2 3 2 3| 17 2.8|
Infiltration Cellular, Mixed Cell | 2 2 3 2 2 2 3 2 | 17 2.4|
Inflammation, Chronic | | 1 3.0|
Metaplasia, Osseous | 1 | 1 1.0|
Nephropathy | 1 2 3 4 1 1 1 1 2 2 2 2 1 4 2 1 4 2 2 1 1 | 42 1.9|
Renal Tubule, Dilatation | 3 2 | 5 2.4|
Renal Tubule, Pigmentation | | 2 3.0|
|__________________________________________________________________________|____________|
Ureter | + | 1 |
Dilatation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Urethra | + + + + | 5 |
Angiectasis | 4 4 | 3 4.0|
Inflammation, Chronic | 3 3 | 3 3.0|
Bulbourethral Gland, Cyst | X X | 2 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Edema | 3| 1 3.0|
Hemorrhage | 3 | 3 2.3|
Inflammation, Chronic | 3 | 2 2.5|
Transitional Epithelium, Hyperplasia | 2 2 2| 3 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 108
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 1| 5| 5| 3| 5| 1| 3| 3| 1| 5| 6| 6| 4| 4| 3| 6| 6| 6| 4| 6|
DAY ON TEST | 1| 7| 3| 0| 2| 5| 3| 6| 2| 8| 5| 2| 2| 6| 3| 0| 7| 3| 1| 4| 7| 7| 6| 8| 6|
| 2| 8| 1| 7| 4| 9| 9| 3| 0| 0| 7| 9| 9| 7| 1| 8| 6| 4| 9| 1| 9| 0| 2| 3| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|
200 | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|
MG/KG/DY | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 3| 4| 5| 6|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + + + + A + + + + A + + + + M + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + A + + + + + + + + + + + + + + + + M + +|
Edema | 2 2 2 3 2 2 2 2 2 2 |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + M + + +|
Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + A + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 3 |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + M + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X |
Cyst | |
Eosinophilic Focus | X |
Hematopoietic Cell Proliferation | 2 2 |
Infiltration Cellular, Mixed Cell | 2 3 3|
Necrosis, Focal | 4 4 1 |
Hepatocyte, Hypertrophy | 2 2 3 3 3 |
Kupffer Cell, Hyperplasia | 3 |
Kupffer Cell, Pigmentation | 2 2 |
|__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 2 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 3 |
Acinus, Cytoplasmic Alteration | |
__________________________________________|__________________________________________________________________________|
Page 109
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 1| 5| 5| 3| 5| 1| 3| 3| 1| 5| 6| 6| 4| 4| 3| 6| 6| 6| 4| 6|
DAY ON TEST | 1| 7| 3| 0| 2| 5| 3| 6| 2| 8| 5| 2| 2| 6| 3| 0| 7| 3| 1| 4| 7| 7| 6| 8| 6|
| 2| 8| 1| 7| 4| 9| 9| 3| 0| 0| 7| 9| 9| 7| 1| 8| 6| 4| 9| 1| 9| 0| 2| 3| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|
200 | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|
MG/KG/DY | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 3| 4| 5| 6|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Infiltration Cellular, Mixed Cell | 2 1 |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Diverticulum | X |
Edema | 2 |
Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 2 |
Glands, Hyperplasia, Cystic | 2 3 2 2 3 3 4 2 2 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 1 1 2 2 1 2 2 |
Inflammation, Chronic | 3 |
Mineralization | 2 |
Thrombosis | X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 3 3 3 |
Hyperplasia, Focal | 1 3 |
Hypertrophy, Focal | 2 |
Capsule, Hyperplasia | 3 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 3 |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + I M + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________|__________________________________________________________________________|
Page 110
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 1| 5| 5| 3| 5| 1| 3| 3| 1| 5| 6| 6| 4| 4| 3| 6| 6| 6| 4| 6|
DAY ON TEST | 1| 7| 3| 0| 2| 5| 3| 6| 2| 8| 5| 2| 2| 6| 3| 0| 7| 3| 1| 4| 7| 7| 6| 8| 6|
| 2| 8| 1| 7| 4| 9| 9| 3| 0| 0| 7| 9| 9| 7| 1| 8| 6| 4| 9| 1| 9| 0| 2| 3| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|
200 | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|
MG/KG/DY | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 3| 4| 5| 6|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Pars Distalis, Cyst | X|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 1 3 3 2 2 2 2 3 2 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Coagulating Gland | + |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | 2 2 |
|__________________________________________________________________________|
Penis | + + |
Inflammation, Chronic Active | |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X |
Inflammation, Chronic | 3 2 4 2 2 2 |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 3 3 2 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 3 |
Inflammation, Chronic | 2 3 |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Atrophy | 2 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 3 3 2 4 3 3 4 4 4 2 2 2 2 3 3 2|
|__________________________________________________________________________|
Lymph Node | + + + |
__________________________________________|__________________________________________________________________________|
Page 111
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 1| 5| 5| 3| 5| 1| 3| 3| 1| 5| 6| 6| 4| 4| 3| 6| 6| 6| 4| 6|
DAY ON TEST | 1| 7| 3| 0| 2| 5| 3| 6| 2| 8| 5| 2| 2| 6| 3| 0| 7| 3| 1| 4| 7| 7| 6| 8| 6|
| 2| 8| 1| 7| 4| 9| 9| 3| 0| 0| 7| 9| 9| 7| 1| 8| 6| 4| 9| 1| 9| 0| 2| 3| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|
200 | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|
MG/KG/DY | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 3| 4| 5| 6|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Hyperplasia, Lymphoid | 4 4 |
Iliac, Hyperplasia, Lymphoid | |
Inguinal, Hematopoietic Cell | |
Proliferation | |
Inguinal, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 3 3 |
Ectasia | |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia, Lymphoid | 2 2 2 3 2 |
Hyperplasia, Plasma Cell | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + M|
Atrophy | 2 3 3 |
Ectasia | 3 3 2 2 4 2 |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | 2 3 4 2 2 3 2 |
Hyperplasia, Lymphoid | 2 2 2 3 3 3 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 4 4 2 4 3 3 1 2 3 3 3 |
Pigmentation | 3 2 |
Lymphoid Follicle, Atrophy | 3 3 2 3 3 3 3 |
Lymphoid Follicle, Hyperplasia | 2 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + M + + I + + + + + + + + +|
Atrophy | 3 3 3 3 2 4 2 3 3 3 |
Cyst | |
Hyperplasia, Lymphoid | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
__________________________________________|__________________________________________________________________________|
Page 112
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 1| 5| 5| 3| 5| 1| 3| 3| 1| 5| 6| 6| 4| 4| 3| 6| 6| 6| 4| 6|
DAY ON TEST | 1| 7| 3| 0| 2| 5| 3| 6| 2| 8| 5| 2| 2| 6| 3| 0| 7| 3| 1| 4| 7| 7| 6| 8| 6|
| 2| 8| 1| 7| 4| 9| 9| 3| 0| 0| 7| 9| 9| 7| 1| 8| 6| 4| 9| 1| 9| 0| 2| 3| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|
200 | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|
MG/KG/DY | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 3| 4| 5| 6|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
Edema | 3 4 3 4 |
Ulcer | 4 4 4 4 |
Epidermis, Hyperplasia | 2 3 3 3 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 |
|__________________________________________________________________________|
Skeletal Muscle | + + |
Pigmentation | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Peripheral Nerve | + + + + + |
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Edema | 2 3 2 3 |
Foreign Body | X |
Hemorrhage | 1 3 2 |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Histiocyte | 2 3 3 4 4 4 4 4 2 2 3 3|
Inflammation, Chronic | 3 |
Alveolar Epithelium, Hyperplasia | 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + M + + + + +|
Inflammation, Chronic | 2 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 113
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 6| 6| 6| 6| 6| 1| 5| 5| 3| 5| 1| 3| 3| 1| 5| 6| 6| 4| 4| 3| 6| 6| 6| 4| 6|
DAY ON TEST | 1| 7| 3| 0| 2| 5| 3| 6| 2| 8| 5| 2| 2| 6| 3| 0| 7| 3| 1| 4| 7| 7| 6| 8| 6|
| 2| 8| 1| 7| 4| 9| 9| 3| 0| 0| 7| 9| 9| 7| 1| 8| 6| 4| 9| 1| 9| 0| 2| 3| 8|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3|
200 | 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|
MG/KG/DY | 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 3| 4| 5| 6|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 3 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X X X X X X X X X X X|
Hydronephrosis | 3 3 2 3 4 2 2 4 2 4 4 |
Infarct | |
Infiltration Cellular, Mixed Cell | 3 3 3 3 2 2 4 |
Inflammation, Chronic | |
Mineralization | 3 |
Nephropathy | 4 2 3 2 2 4 2 2 1 4 2 2 2 1 3 1 3 3 1|
Renal Tubule, Dilatation | 2 |
Renal Tubule, Necrosis | 4 |
Renal Tubule, Pigmentation | 2 2 |
|__________________________________________________________________________|
Ureter | + |
Dilatation | 1 |
|__________________________________________________________________________|
Urethra | + |
Angiectasis | |
Inflammation, Chronic | |
Bulbourethral Gland, Cyst | X |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 |
Inflammation, Chronic | |
Transitional Epithelium, Hyperplasia | 2 |
__________________________________________|__________________________________________________________________________
Page 114
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 5| 2| 6| 6| 6| 3| 3| 5| 6| 5| 6| 5| | |
DAY ON TEST | 0| 9| 4| 3| 7| 8| 0| 4| 2| 8| 7| 9| | |
| 1| 8| 7| 1| 1| 2| 1| 9| 5| 9| 0| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
200 | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| | L |
MG/KG/DY | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + | 37 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + A + + + + + + | 33 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + | 37 |
Edema | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + | 37 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + | 35 |
Edema | 2 2 2 2 | 14 2.1|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + | 36 |
Epithelium, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + | 36 |
Epithelium, Hyperplasia | | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + M + + + + + | 35 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + | 37 |
Basophilic Focus | X | 2 |
Cyst | X | 1 |
Eosinophilic Focus | | 1 |
Hematopoietic Cell Proliferation | 4 4 3 4 | 6 3.2|
Infiltration Cellular, Mixed Cell | 3 2 | 5 2.6|
Necrosis, Focal | 1 | 4 2.5|
Hepatocyte, Hypertrophy | 2 | 6 2.5|
Kupffer Cell, Hyperplasia | | 1 3.0|
Kupffer Cell, Pigmentation | | 2 2.0|
|__________________________________________________________________________|____________|
Mesentery | + + | 3 |
Fat, Necrosis | 3 3 | 3 2.7|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 115
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 5| 2| 6| 6| 6| 3| 3| 5| 6| 5| 6| 5| | |
DAY ON TEST | 0| 9| 4| 3| 7| 8| 0| 4| 2| 8| 7| 9| | |
| 1| 8| 7| 1| 1| 2| 1| 9| 5| 9| 0| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
200 | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| | L |
MG/KG/DY | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + | 37 |
Edema | | 2 3.0|
Acinus, Cytoplasmic Alteration | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + | 37 |
Atrophy | | 1 2.0|
Infiltration Cellular, Mixed Cell | | 2 1.5|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + | 37 |
Diverticulum | | 1 |
Edema | | 1 2.0|
Epithelium, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + | 37 |
Edema | 2 | 2 2.0|
Glands, Hyperplasia, Cystic | 2 4 2 2 3 | 15 2.5|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + | 37 |
Cardiomyopathy | 1 1 3 2 2 | 13 1.7|
Inflammation, Chronic | 2 | 2 2.5|
Mineralization | | 1 2.0|
Thrombosis | | 3 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + | 37 |
Accessory Adrenal Cortical Nodule | 3 3 3 | 6 3.0|
Hyperplasia, Focal | | 2 2.0|
Hypertrophy, Focal | 2 3 2 | 4 2.3|
Capsule, Hyperplasia | 2 | 3 2.3|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 116
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 5| 2| 6| 6| 6| 3| 3| 5| 6| 5| 6| 5| | |
DAY ON TEST | 0| 9| 4| 3| 7| 8| 0| 4| 2| 8| 7| 9| | |
| 1| 8| 7| 1| 1| 2| 1| 9| 5| 9| 0| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
200 | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| | L |
MG/KG/DY | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Adrenal Medulla | + + + + + + + + + + + + | 37 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + M + + + + + + + | 36 |
Hyperplasia | 1 | 6 2.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + | 35 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + | 36 |
Pars Distalis, Cyst | X | 2 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + | 37 |
Degeneration, Cystic | 3 2 1 2 | 15 2.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Coagulating Gland | | 1 |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + | 37 |
Atypia Cellular | 2 | 3 2.0|
|__________________________________________________________________________|____________|
Penis | + | 3 |
Inflammation, Chronic Active | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + | 37 |
Cyst | X X | 6 |
Inflammation, Chronic | 3 3 | 8 2.6|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + | 37 |
Inflammation, Chronic | 4 2 | 6 2.8|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + | 37 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 117
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 5| 2| 6| 6| 6| 3| 3| 5| 6| 5| 6| 5| | |
DAY ON TEST | 0| 9| 4| 3| 7| 8| 0| 4| 2| 8| 7| 9| | |
| 1| 8| 7| 1| 1| 2| 1| 9| 5| 9| 0| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
200 | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| | L |
MG/KG/DY | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Degeneration | | 1 3.0|
Inflammation, Chronic | 4 | 3 3.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + | 37 |
Germinal Epithelium, Atrophy | 2 | 3 1.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + | 37 |
Hyperplasia | 3 4 4 4 2 3 2 3 3 4 | 27 3.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + | 6 |
Hyperplasia, Lymphoid | | 2 4.0|
Iliac, Hyperplasia, Lymphoid | 4 | 1 4.0|
Inguinal, Hematopoietic Cell | | |
Proliferation | 3 | 1 3.0|
Inguinal, Hyperplasia, Lymphoid | 3 | 1 3.0|
Renal, Hyperplasia, Lymphoid | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + | 37 |
Atrophy | | 3 2.7|
Ectasia | 4 | 1 4.0|
Hematopoietic Cell Proliferation | 3 2 3 | 4 2.5|
Hyperplasia, Lymphoid | 4 | 6 2.5|
Hyperplasia, Plasma Cell | 3 2 2 | 3 2.3|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + | 36 |
Atrophy | | 3 2.7|
Ectasia | | 6 2.7|
Hematopoietic Cell Proliferation | 3 2 | 3 2.3|
Hemorrhage | 1 | 8 2.4|
Hyperplasia, Lymphoid | 2 3 4 2 | 10 2.6|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + | 37 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 118
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 5| 2| 6| 6| 6| 3| 3| 5| 6| 5| 6| 5| | |
DAY ON TEST | 0| 9| 4| 3| 7| 8| 0| 4| 2| 8| 7| 9| | |
| 1| 8| 7| 1| 1| 2| 1| 9| 5| 9| 0| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
200 | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| | L |
MG/KG/DY | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Hematopoietic Cell Proliferation | 4 4 3 4 3 4 | 18 3.1|
Pigmentation | | 2 2.5|
Lymphoid Follicle, Atrophy | | 7 2.9|
Lymphoid Follicle, Hyperplasia | 3 | 2 2.5|
|__________________________________________________________________________|____________|
Thymus | + + + M + M + + + + + + | 33 |
Atrophy | 2 3 3 | 13 2.8|
Cyst | X | 1 |
Hyperplasia, Lymphoid | | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + | 37 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + | 37 |
Cyst Epithelial Inclusion | X | 1 |
Edema | 3 2 2 | 7 3.0|
Ulcer | 4 4 4 | 7 4.0|
Epidermis, Hyperplasia | 4 4 3 | 8 3.3|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + | 37 |
Fibrous Osteodystrophy | | 1 2.0|
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 3 |
Pigmentation | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + | 37 |
|__________________________________________________________________________|____________|
Peripheral Nerve | + + | 7 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 119
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 5| 2| 6| 6| 6| 3| 3| 5| 6| 5| 6| 5| | |
DAY ON TEST | 0| 9| 4| 3| 7| 8| 0| 4| 2| 8| 7| 9| | |
| 1| 8| 7| 1| 1| 2| 1| 9| 5| 9| 0| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
200 | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| | L |
MG/KG/DY | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
Spinal Cord | + + + + + + + + + + + + | 37 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + | 37 |
Congestion | | 1 3.0|
Edema | | 4 2.5|
Foreign Body | | 1 |
Hemorrhage | 1 1 | 5 1.6|
Hyperplasia, Lymphoid | 1 | 1 1.0|
Infiltration Cellular, Histiocyte | 3 3 4 3 | 16 3.2|
Inflammation, Chronic | 2 | 2 2.5|
Alveolar Epithelium, Hyperplasia | | 1 1.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + | 36 |
Inflammation, Chronic | 1 | 3 1.7|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + | 37 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + | 37 |
Hyperplasia, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + | 37 |
Cyst | X X X X X X X X X | 24 |
Hydronephrosis | 4 2 2 3 3 | 16 2.9|
Infarct | 4 | 1 4.0|
Infiltration Cellular, Mixed Cell | 2 2 | 9 2.7|
Inflammation, Chronic | 2 2 | 2 2.0|
Mineralization | | 1 3.0|
Nephropathy | 1 2 1 2 1 1 1 3 1 3 2 | 30 2.1|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 120
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 5| 2| 6| 6| 6| 3| 3| 5| 6| 5| 6| 5| | |
DAY ON TEST | 0| 9| 4| 3| 7| 8| 0| 4| 2| 8| 7| 9| | |
| 1| 8| 7| 1| 1| 2| 1| 9| 5| 9| 0| 9| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
200 | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| | L |
MG/KG/DY | 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Renal Tubule, Dilatation | 3 | 2 2.5|
Renal Tubule, Necrosis | | 1 4.0|
Renal Tubule, Pigmentation | | 2 2.0|
|__________________________________________________________________________|____________|
Ureter | | 1 |
Dilatation | | 1 1.0|
|__________________________________________________________________________|____________|
Urethra | + + | 3 |
Angiectasis | 4 | 1 4.0|
Inflammation, Chronic | 3 | 1 3.0|
Bulbourethral Gland, Cyst | | 1 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + | 37 |
Hemorrhage | 4 | 2 3.5|
Inflammation, Chronic | 2 | 1 2.0|
Transitional Epithelium, Hyperplasia | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 121
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 6| 5| 6| 6| 4| 3| 6| 1| 6| 5| 6| 6| 6| 3| 3| 3| 6| 6| 6| 5| 6| 6| 4| 0| 0|
DAY ON TEST | 7| 3| 4| 7| 9| 2| 7| 9| 7| 9| 3| 7| 5| 2| 7| 2| 3| 7| 3| 6| 7| 6| 7| 4| 4|
| 7| 8| 0| 7| 5| 9| 8| 2| 8| 3| 4| 6| 5| 9| 6| 9| 5| 3| 8| 3| 8| 1| 3| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
MG/KG/DY | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Gallbladder | + + A + + + + + + + + + + + A + + + A + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + A + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + + + + + A +|
Edema | 2 |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + A + + + + + A|
Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + + + + A +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Amyloid Deposition | 2 |
Angiectasis | 2 |
Eosinophilic Focus | X |
Hematopoietic Cell Proliferation | 2 2 2 |
Hemorrhage | 3 |
Infarct | 2 |
Infiltration Cellular, Mixed Cell | 2 |
Necrosis, Focal | 4 1 1 |
Regeneration | X |
Tension Lipidosis | X |
Hepatocyte, Hypertrophy | 3 2 3 2 2 2 2 2 2 2 2 3 2 |
Hepatocyte, Vacuolization Cytoplasmic| 2 |
Hepatocyte, Centrilobular, | |
Vacuolization Cytoplasmic | 3 |
Kupffer Cell, Hyperplasia | 3 |
Kupffer Cell, Pigmentation | 2 3 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 122
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 6| 5| 6| 6| 4| 3| 6| 1| 6| 5| 6| 6| 6| 3| 3| 3| 6| 6| 6| 5| 6| 6| 4| 0| 0|
DAY ON TEST | 7| 3| 4| 7| 9| 2| 7| 9| 7| 9| 3| 7| 5| 2| 7| 2| 3| 7| 3| 6| 7| 6| 7| 4| 4|
| 7| 8| 0| 7| 5| 9| 8| 2| 8| 3| 4| 6| 5| 9| 6| 9| 5| 3| 8| 3| 8| 1| 3| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
MG/KG/DY | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Mesentery | + |
Hemorrhage | 3 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + A + + + + + + + + + +|
Cyst | X |
Infiltration Cellular, Mixed Cell | |
Acinus, Cytoplasmic Alteration | |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
Infiltration Cellular, Lymphoid | 1 2 2 2 |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Glands, Hyperplasia, Cystic | 2 3 2 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 2 1 2 1 2 |
Inflammation, Chronic | |
Thrombosis | X X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | 3 3 3 3 |
Hypertrophy, Focal | 2 2 |
Capsule, Hyperplasia | 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + A + + + + + + + + + +|
Hyperplasia | 1 3 3 2 |
__________________________________________|__________________________________________________________________________|
Page 123
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 6| 5| 6| 6| 4| 3| 6| 1| 6| 5| 6| 6| 6| 3| 3| 3| 6| 6| 6| 5| 6| 6| 4| 0| 0|
DAY ON TEST | 7| 3| 4| 7| 9| 2| 7| 9| 7| 9| 3| 7| 5| 2| 7| 2| 3| 7| 3| 6| 7| 6| 7| 4| 4|
| 7| 8| 0| 7| 5| 9| 8| 2| 8| 3| 4| 6| 5| 9| 6| 9| 5| 3| 8| 3| 8| 1| 3| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
MG/KG/DY | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + M I + I + + + + + + M|
|__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Cyst | X |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 3 2 2 3 3 2 3 2 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Coagulating Gland | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atypia Cellular | 2 3 2 |
Spermatocele | 3 |
|__________________________________________________________________________|
Penis | + |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Inflammation, Chronic | 4 2 2 2 2 3 2 4 |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 4 2 3 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 3 |
Dilatation | 4 2 |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Atrophy | 3 2 2 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 124
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 6| 5| 6| 6| 4| 3| 6| 1| 6| 5| 6| 6| 6| 3| 3| 3| 6| 6| 6| 5| 6| 6| 4| 0| 0|
DAY ON TEST | 7| 3| 4| 7| 9| 2| 7| 9| 7| 9| 3| 7| 5| 2| 7| 2| 3| 7| 3| 6| 7| 6| 7| 4| 4|
| 7| 8| 0| 7| 5| 9| 8| 2| 8| 3| 4| 6| 5| 9| 6| 9| 5| 3| 8| 3| 8| 1| 3| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
MG/KG/DY | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 4 2 2 4 4 2 3 4 2 4 4 2 2 2 2 3 3 3 |
Myelofibrosis | 3 |
|__________________________________________________________________________|
Lymph Node | + + |
Hyperplasia, Plasma Cell | 4 3 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 4 3 |
Hematopoietic Cell Proliferation | 2 2 2 |
Hyperplasia, Lymphoid | 2 2 2 3 4 4 2 |
Hyperplasia, Plasma Cell | 3 2 3 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hematopoietic Cell Proliferation | 2 3 2 |
Hemorrhage | 1 1 4 4 3 2 2 |
Hyperplasia, Lymphoid | 2 2 2 2 3 |
Pigmentation | 2 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 2 2 3 4 1 4 2 3 3 4 3 1 3 2 4 3|
Lymphoid Follicle, Atrophy | 3 |
Lymphoid Follicle, Hyperplasia | 2 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 2 2 3 3 |
Cyst | |
Hyperplasia, Lymphoid | 2 3 2 1 2 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | |
Ulcer | 4 4 4 4 4 |
Epidermis, Hyperplasia | 4 4 4 3 |
__________________________________________|__________________________________________________________________________|
Page 125
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 6| 5| 6| 6| 4| 3| 6| 1| 6| 5| 6| 6| 6| 3| 3| 3| 6| 6| 6| 5| 6| 6| 4| 0| 0|
DAY ON TEST | 7| 3| 4| 7| 9| 2| 7| 9| 7| 9| 3| 7| 5| 2| 7| 2| 3| 7| 3| 6| 7| 6| 7| 4| 4|
| 7| 8| 0| 7| 5| 9| 8| 2| 8| 3| 4| 6| 5| 9| 6| 9| 5| 3| 8| 3| 8| 1| 3| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
MG/KG/DY | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | |
Fracture | |
Femur, Osteopetrosis | 2 4 |
Scapula, Osteopetrosis | 3 |
|__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
|__________________________________________________________________________|
Peripheral Nerve | + + |
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | X |
Demyelination | 3 |
Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | X |
Hemorrhage | 2 3 |
Hyperplasia, Lymphoid | 3 |
Infiltration Cellular, Histiocyte | 4 2 2 1 4 2 4 3 4 3 4 4 3 |
Inflammation, Chronic | 3 |
Alveolar Epithelium, Hyperplasia | 3 3 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 1 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 126
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
_____________________________________________________________________________________________________________________
| 6| 5| 6| 6| 4| 3| 6| 1| 6| 5| 6| 6| 6| 3| 3| 3| 6| 6| 6| 5| 6| 6| 4| 0| 0|
DAY ON TEST | 7| 3| 4| 7| 9| 2| 7| 9| 7| 9| 3| 7| 5| 2| 7| 2| 3| 7| 3| 6| 7| 6| 7| 4| 4|
| 7| 8| 0| 7| 5| 9| 8| 2| 8| 3| 4| 6| 5| 9| 6| 9| 5| 3| 8| 3| 8| 1| 3| 1| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
300 | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|
MG/KG/DY | 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
|__________________________________________________________________________|
Lacrimal Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X X X X X X X X X |
Hydronephrosis | 2 3 2 2 2 2 2 2 3 2|
Infarct | 2 |
Infiltration Cellular, Mixed Cell | 2 2 2 2 2 2 3 2 2 |
Nephropathy | 2 1 1 1 1 2 1 1 2 2 3 3 4 1 2 3 2 |
Renal Tubule, Dilatation | |
|__________________________________________________________________________|
Urethra | + + + |
Angiectasis | 4 |
Bulbourethral Gland, Cyst | X X |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Edema | 3 3 |
Hemorrhage | 2 |
Inflammation, Chronic | 3 |
Transitional Epithelium, Hyperplasia | |
__________________________________________|__________________________________________________________________________
Page 127
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 4| 5| 2| 4| | |
DAY ON TEST | 6| 6| 2| 0| 3| 2| 8| | |
| 9| 8| 7| 4| 9| 9| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| | A |
300 | 1| 1| 2| 2| 2| 2| 2| | L |
MG/KG/DY | 8| 9| 0| 1| 2| 3| 4| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + | 32 |
|__________________________________________________________________________|____________|
Gallbladder | + + + A A + + | 27 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + | 32 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + | 31 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + | 30 |
Edema | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + | 32 |
Epithelium, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + | 29 |
Epithelium, Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + | 30 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + | 32 |
Amyloid Deposition | | 1 2.0|
Angiectasis | | 1 2.0|
Eosinophilic Focus | X | 2 |
Hematopoietic Cell Proliferation | 4 2 | 5 2.4|
Hemorrhage | | 1 3.0|
Infarct | | 1 2.0|
Infiltration Cellular, Mixed Cell | 2 | 2 2.0|
Necrosis, Focal | | 3 2.0|
Regeneration | | 1 |
Tension Lipidosis | | 1 |
Hepatocyte, Hypertrophy | 2 3 | 15 2.3|
Hepatocyte, Vacuolization Cytoplasmic| | 1 2.0|
Hepatocyte, Centrilobular, | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 128
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 4| 5| 2| 4| | |
DAY ON TEST | 6| 6| 2| 0| 3| 2| 8| | |
| 9| 8| 7| 4| 9| 9| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| | A |
300 | 1| 1| 2| 2| 2| 2| 2| | L |
MG/KG/DY | 8| 9| 0| 1| 2| 3| 4| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Vacuolization Cytoplasmic | | 1 3.0|
Kupffer Cell, Hyperplasia | | 1 3.0|
Kupffer Cell, Pigmentation | 2 | 3 2.3|
|__________________________________________________________________________|____________|
Mesentery | | 1 |
Hemorrhage | | 1 3.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + | 31 |
Cyst | | 1 |
Infiltration Cellular, Mixed Cell | 2 | 1 2.0|
Acinus, Cytoplasmic Alteration | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + | 32 |
Hyperplasia, Lymphoid | | 1 2.0|
Infiltration Cellular, Lymphoid | 2 | 5 1.8|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + | 32 |
Epithelium, Hyperplasia | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + | 32 |
Erosion | 2 | 1 2.0|
Glands, Hyperplasia, Cystic | 2 3 | 6 2.3|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + | 32 |
Cardiomyopathy | | 7 1.7|
Inflammation, Chronic | 1 | 1 1.0|
Thrombosis | | 3 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + | 32 |
Accessory Adrenal Cortical Nodule | 3 3 | 6 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 129
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 4| 5| 2| 4| | |
DAY ON TEST | 6| 6| 2| 0| 3| 2| 8| | |
| 9| 8| 7| 4| 9| 9| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| | A |
300 | 1| 1| 2| 2| 2| 2| 2| | L |
MG/KG/DY | 8| 9| 0| 1| 2| 3| 4| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Hypertrophy, Focal | 2 2 | 4 2.0|
Capsule, Hyperplasia | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + | 32 |
Hyperplasia | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + | 31 |
Hyperplasia | 2 1 | 6 2.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + | 28 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + | 31 |
Pars Distalis, Cyst | | 1 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + | 32 |
Degeneration, Cystic | 2 2 1 2 3 | 15 2.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Coagulating Gland | + | 1 |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + | 32 |
Atypia Cellular | | 3 2.3|
Spermatocele | | 1 3.0|
|__________________________________________________________________________|____________|
Penis | | 1 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + | 32 |
Cyst | X | 2 |
Inflammation, Chronic | 2 | 9 2.6|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 130
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 4| 5| 2| 4| | |
DAY ON TEST | 6| 6| 2| 0| 3| 2| 8| | |
| 9| 8| 7| 4| 9| 9| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| | A |
300 | 1| 1| 2| 2| 2| 2| 2| | L |
MG/KG/DY | 8| 9| 0| 1| 2| 3| 4| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Prostate | + + + + + + + | 32 |
Inflammation, Chronic | 2 | 5 2.8|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + | 32 |
Degeneration | | 1 3.0|
Dilatation | 3 | 3 3.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + | 32 |
Germinal Epithelium, Atrophy | | 4 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + | 32 |
Hyperplasia | 3 2 3 3 3 | 24 2.9|
Myelofibrosis | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node | | 2 |
Hyperplasia, Plasma Cell | | 2 3.5|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + | 32 |
Ectasia | | 2 3.5|
Hematopoietic Cell Proliferation | 2 3 | 5 2.2|
Hyperplasia, Lymphoid | 3 3 | 9 2.8|
Hyperplasia, Plasma Cell | | 4 2.5|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + | 32 |
Ectasia | 2 3 | 2 2.5|
Hematopoietic Cell Proliferation | 2 | 4 2.3|
Hemorrhage | 1 1 | 9 2.1|
Hyperplasia, Lymphoid | 4 | 6 2.5|
Pigmentation | | 1 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + | 32 |
Hematopoietic Cell Proliferation | 1 1 4 | 20 2.7|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 131
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 4| 5| 2| 4| | |
DAY ON TEST | 6| 6| 2| 0| 3| 2| 8| | |
| 9| 8| 7| 4| 9| 9| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| | A |
300 | 1| 1| 2| 2| 2| 2| 2| | L |
MG/KG/DY | 8| 9| 0| 1| 2| 3| 4| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Lymphoid Follicle, Atrophy | 3 | 2 3.0|
Lymphoid Follicle, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + | 32 |
Atrophy | 3 2 | 7 2.6|
Cyst | X | 1 |
Hyperplasia, Lymphoid | | 6 2.2|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + | 32 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + | 32 |
Edema | 2 | 1 2.0|
Ulcer | 4 | 6 4.0|
Epidermis, Hyperplasia | 3 | 5 3.6|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + | 32 |
Fibrous Osteodystrophy | 2 | 1 2.0|
Fracture | X | 1 |
Femur, Osteopetrosis | | 2 3.0|
Scapula, Osteopetrosis | | 1 3.0|
|__________________________________________________________________________|____________|
Skeletal Muscle | | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + | 32 |
Necrosis | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | + | 3 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 132
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 4| 5| 2| 4| | |
DAY ON TEST | 6| 6| 2| 0| 3| 2| 8| | |
| 9| 8| 7| 4| 9| 9| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| | A |
300 | 1| 1| 2| 2| 2| 2| 2| | L |
MG/KG/DY | 8| 9| 0| 1| 2| 3| 4| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
Spinal Cord | + + + + + + + | 32 |
Cyst Epithelial Inclusion | | 1 |
Demyelination | | 1 3.0|
Necrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | | 1 |
|__________________________________________________________________________|____________|
Lung | + + + + + + + | 32 |
Foreign Body | | 1 |
Hemorrhage | | 2 2.5|
Hyperplasia, Lymphoid | | 1 3.0|
Infiltration Cellular, Histiocyte | 2 | 14 3.0|
Inflammation, Chronic | | 1 3.0|
Alveolar Epithelium, Hyperplasia | 4 | 4 2.8|
|__________________________________________________________________________|____________|
Nose | + + + + + + + | 32 |
Inflammation, Chronic | 2 2 | 4 1.8|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + | 32 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + | 32 |
Hyperplasia, Focal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lacrimal Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + | 32 |
Cyst | X X X X | 17 |
Hydronephrosis | 3 2 2 3 | 14 2.3|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 133
NTP Experiment-Test: 99022-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: PERINATAL EXPOS AZT TRANSPLACENTAL CARCINOGENESIS STUDY Date: 09/09/04
Route: IN-UTERO Time: 14:01:42
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 4| 5| 2| 4| | |
DAY ON TEST | 6| 6| 2| 0| 3| 2| 8| | |
| 9| 8| 7| 4| 9| 9| 8| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| | O |
SWISS MICE MALE | 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| | A |
300 | 1| 1| 2| 2| 2| 2| 2| | L |
MG/KG/DY | 8| 9| 0| 1| 2| 3| 4| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Infarct | | 1 2.0|
Infiltration Cellular, Mixed Cell | 3 3 2 | 12 2.3|
Nephropathy | 1 2 4 1 1 4 | 23 2.0|
Renal Tubule, Dilatation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Urethra | | 3 |
Angiectasis | | 1 4.0|
Bulbourethral Gland, Cyst | | 2 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + | 32 |
Edema | | 2 3.0|
Hemorrhage | 2 | 2 2.0|
Inflammation, Chronic | | 1 3.0|
Transitional Epithelium, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 134
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