TDMS Study 88138-03 Pathology Tables
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
FINAL #1 RATS
Facility: Battelle Columbus Laboratory
Chemical CAS #: 119-61-9
Lock Date: 04/26/02
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 2| 2| 1| 3| 3| 2| 2| 3| 3| 2| 3| 3| 3| 3| 3| 0| 2| 2| 2| 7| 0| 3|
| 0| 0| 0| 9| 9| 3| 0| 0| 9| 4| 4| 0| 8| 1| 0| 1| 0| 7| 8| 5| 9| 9| 3| 8| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Metaplasia, Mucous | |
Parasite Metazoan | 1 |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 1 1 1 1 1 |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X|
Degeneration, Cystic | |
Fatty Change, Diffuse | 2 1 |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 2 2 1 1 1 1 1 2 1 1 1 1 1 1 1|
Mixed Cell Focus | X X X X|
Necrosis | 1 1 1 1|
Bile Duct, Hyperplasia | 1 1 1 |
|__________________________________________________________________________|
Mesentery | + + + + |
Fat, Necrosis | 2 1 1 1 |
|__________________________________________________________________________|
Oral Mucosa | + |
Gingival, Inflammation | 1 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 2
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 2| 2| 1| 3| 3| 2| 2| 3| 3| 2| 3| 3| 3| 3| 3| 0| 2| 2| 2| 7| 0| 3|
| 0| 0| 0| 9| 9| 3| 0| 0| 9| 4| 4| 0| 8| 1| 0| 1| 0| 7| 8| 5| 9| 9| 3| 8| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 3 1 1 |
Acinus, Atrophy | 1 1 1 1 1 1 1 1 1 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Basophilic Focus | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | |
Inflammation | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 2 1 1 2 1 1 1 1 2 1 1 2 1 1 1 1 1 1 1 1 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 1 1 2 1 1 2 2 1 1 1 1 1 1 1 2 2 2 1 1 2 2 3 1|
Atrophy | 1 |
Degeneration, Cystic | |
Hematopoietic Cell Proliferation | |
Hyperplasia | 1 1 |
Hypertrophy | 1 1 1 1 1 |
Karyomegaly | 1 |
Necrosis | 1 2 |
Vacuolization Cytoplasmic | 1 1 2 1 1 1 1 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | 1 |
Vacuolization Cytoplasmic | |
__________________________________________|__________________________________________________________________________|
Page 3
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 2| 2| 1| 3| 3| 2| 2| 3| 3| 2| 3| 3| 3| 3| 3| 0| 2| 2| 2| 7| 0| 3|
| 0| 0| 0| 9| 9| 3| 0| 0| 9| 4| 4| 0| 8| 1| 0| 1| 0| 7| 8| 5| 9| 9| 3| 8| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + M + + + + M + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 1 1 1 4 2 1 2 1 2 3 3 2 1 4|
Cyst | |
Hyperplasia | 1 2 1 3 1 1 4 2 2 1 2 4 1 1 |
Inflammation | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 3 4 3 2 2 1 2 4 2 1 1 1 1 3 3 1 1 1 1 1|
Follicle, Cyst | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Hyperplasia | 2 4 2|
Inflammation | |
Metaplasia, Squamous | 2 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic | 1 1 2 1 4 1 1|
Endometrium, Hyperplasia, Adenomatous| 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | |
Myelofibrosis | |
__________________________________________|__________________________________________________________________________|
Page 4
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 2| 2| 1| 3| 3| 2| 2| 3| 3| 2| 3| 3| 3| 3| 3| 0| 2| 2| 2| 7| 0| 3|
| 0| 0| 0| 9| 9| 3| 0| 0| 9| 4| 4| 0| 8| 1| 0| 1| 0| 7| 8| 5| 9| 9| 3| 8| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Erythroid Cell, Hyperplasia | 1 1 1 1 1 2 1 |
Myeloid Cell, Hyperplasia | 1 2 1 3 3 1 |
|__________________________________________________________________________|
Lymph Node | + + + + |
Deep Cervical, Ectasia | 1 |
Deep Cervical, Hemorrhage | |
Deep Cervical, Infiltration Cellular,| |
Plasma Cell | 2 1 |
Deep Cervical, Infiltration Cellular,| |
Histiocyte | 1 2 |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Histiocyte | 1 1 2 1 2 3 2 1 1 1 1 2 1 2 2 2 2 1 2 1 2 2 1 1 2|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 1 1 1 1 1 2 2 2 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1|
Infarct | |
Inflammation, Granulomatous | 2 |
Pigmentation, Hemosiderin | 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1|
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 3 4 3 4 4 4 3 3 3 3 3 3 3 4 4 4 3 3 4 3 3 4 3 3|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 4 4 4 4 |
Hyperplasia | 1 |
Inflammation | |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 5
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 2| 2| 1| 3| 3| 2| 2| 3| 3| 2| 3| 3| 3| 3| 3| 0| 2| 2| 2| 7| 0| 3|
| 0| 0| 0| 9| 9| 3| 0| 0| 9| 4| 4| 0| 8| 1| 0| 1| 0| 7| 8| 5| 9| 9| 3| 8| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | |
Inflammation | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 4 |
Hydrocephalus | 3 |
Inflammation | 1 |
Mineralization | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | 1 1 2 1 1 1 1 1 1 |
Alveolar Epithelium, Hyperplasia | 1 1 2 1 1 1 3 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2|
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 3 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Lens, Cataract | |
Retina, Degeneration | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 6
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7|
DAY ON TEST | 3| 3| 3| 2| 2| 1| 3| 3| 2| 2| 3| 3| 2| 3| 3| 3| 3| 3| 0| 2| 2| 2| 7| 0| 3|
| 0| 0| 0| 9| 9| 3| 0| 0| 9| 4| 4| 0| 8| 1| 0| 1| 0| 7| 8| 5| 9| 9| 3| 8| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 4 |
Inflammation, Chronic Active | 2 |
Nephropathy | 1 1 1 1 1 1 3 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Cortex, Mineralization | 1 |
Medulla, Fibrosis | 2 |
Medulla, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1|
Pelvis, Inflammation | 3 |
Pelvis, Transitional Epithelium, | |
Hyperplasia | 1 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________|__________________________________________________________________________
Page 7
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 2| 3| 7| 7| 7| 4| 7| |
DAY ON TEST | 3| 3| 3| 2| 2| 3| 3| 3| 2| 3| 3| 9| 3| 3| 3| 2| 3| 4| 8| 5| 3| 2| 3| 3| 3| |
| 1| 1| 1| 4| 4| 0| 0| 1| 4| 0| 0| 7| 0| 0| 0| 9| 1| 3| 8| 8| 1| 4| 1| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 2 | 1 2.0|
Metaplasia, Mucous | 3 | 1 3.0|
Parasite Metazoan | | 1 1.0|
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | 1 2 | 8 1.1|
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 2 1.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X| 48 |
Clear Cell Focus | X X X X X X X X| 15 |
Degeneration, Cystic | 1 | 1 1.0|
Fatty Change, Diffuse | 1 1 1 1 2 1 3 2 2 | 11 1.5|
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Hepatodiaphragmatic Nodule | X X X X | 5 |
Inflammation, Chronic Active | 2 2 2 2 2 2 2 2 2 2 1 3 2 2 2 2 1 2 2 1 2 2 2| 46 1.5|
Mixed Cell Focus | X X X X X X | 10 |
Necrosis | 1 1 1 1 1 2 1 1 | 12 1.1|
Bile Duct, Hyperplasia | 2 2 2 1 1 1 1| 10 1.3|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + + | 12 |
Fat, Necrosis | 2 1 2 1 2 1 1 | 11 1.4|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 2| 3| 7| 7| 7| 4| 7| |
DAY ON TEST | 3| 3| 3| 2| 2| 3| 3| 3| 2| 3| 3| 9| 3| 3| 3| 2| 3| 4| 8| 5| 3| 2| 3| 3| 3| |
| 1| 1| 1| 4| 4| 0| 0| 1| 4| 0| 0| 7| 0| 0| 0| 9| 1| 3| 8| 8| 1| 4| 1| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Oral Mucosa | + + + | 4 |
Gingival, Inflammation | 1 1 3 | 4 1.5|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1 1 1 1 1 1 | 12 1.2|
Acinus, Atrophy | 1 4 1 1 1 1 1 1| 17 1.2|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 | 2 1.0|
Basophilic Focus | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Squamous | 3 1 | 2 2.0|
Inflammation | 1 1 2 1 | 4 1.3|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 2 1 1 1 1 2 2 1 1 1 2 1 2 1 1 2 1 1 2 1 1| 46 1.3|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 1 1 2 1 2 1 2 1 1 1 1 2 1 1 2 1| 42 1.4|
Atrophy | | 1 1.0|
Degeneration, Cystic | 1 1 1 | 3 1.0|
Hematopoietic Cell Proliferation | 1 1 1 | 3 1.0|
Hyperplasia | 1 2 1 1 | 6 1.2|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 2| 3| 7| 7| 7| 4| 7| |
DAY ON TEST | 3| 3| 3| 2| 2| 3| 3| 3| 2| 3| 3| 9| 3| 3| 3| 2| 3| 4| 8| 5| 3| 2| 3| 3| 3| |
| 1| 1| 1| 4| 4| 0| 0| 1| 4| 0| 0| 7| 0| 0| 0| 9| 1| 3| 8| 8| 1| 4| 1| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Hypertrophy | 1 1| 7 1.0|
Karyomegaly | | 1 1.0|
Necrosis | 2 1 1 | 5 1.4|
Vacuolization Cytoplasmic | 2 1 1 1 1 3 | 14 1.3|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | 3 | 2 2.0|
Vacuolization Cytoplasmic | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 1 2 2 4 2 4 4 1 1 4 2 1 4 2| 30 2.2|
Cyst | 1 1 | 2 1.0|
Hyperplasia | 2 4 2 1 4 4 3 4 1 | 23 2.2|
Inflammation | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 4 2 1 1 1 3 1 1 4 1 1 1 1| 34 1.8|
Follicle, Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 2 4| 3 2.3|
Hyperplasia | 2 2 1 | 6 2.2|
Inflammation | 3 3| 2 3.0|
Metaplasia, Squamous | | 1 2.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 2| 3| 7| 7| 7| 4| 7| |
DAY ON TEST | 3| 3| 3| 2| 2| 3| 3| 3| 2| 3| 3| 9| 3| 3| 3| 2| 3| 4| 8| 5| 3| 2| 3| 3| 3| |
| 1| 1| 1| 4| 4| 0| 0| 1| 4| 0| 0| 7| 0| 0| 0| 9| 1| 3| 8| 8| 1| 4| 1| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X X | 6 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Endometrium, Hyperplasia, Cystic | 2 4 2 1 1| 12 1.8|
Endometrium, Hyperplasia, Adenomatous| | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Granulomatous | 2 | 1 2.0|
Myelofibrosis | 1 1 | 2 1.0|
Erythroid Cell, Hyperplasia | 1 | 8 1.1|
Myeloid Cell, Hyperplasia | 4 1 1 1 1 | 11 1.7|
|__________________________________________________________________________|____________|
Lymph Node | + + + + | 8 |
Deep Cervical, Ectasia | | 1 1.0|
Deep Cervical, Hemorrhage | 2 | 1 2.0|
Deep Cervical, Infiltration Cellular,| | |
Plasma Cell | 2 | 3 1.7|
Deep Cervical, Infiltration Cellular,| | |
Histiocyte | 2 | 3 1.7|
Mediastinal, Infiltration Cellular, | | |
Plasma Cell | 2 1 | 2 1.5|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M| |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Histiocyte | 2 1 1 2 2 2 1 1 2 1 1 1 1 2 1 3 1 2 1 3 1 1 3 1 2| 50 1.6|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + A + + + + + +| 49 |
Fibrosis | | 1 3.0|
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 47 1.1|
Infarct | 4 | 1 4.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 2| 3| 7| 7| 7| 4| 7| |
DAY ON TEST | 3| 3| 3| 2| 2| 3| 3| 3| 2| 3| 3| 9| 3| 3| 3| 2| 3| 4| 8| 5| 3| 2| 3| 3| 3| |
| 1| 1| 1| 4| 4| 0| 0| 1| 4| 0| 0| 7| 0| 0| 0| 9| 1| 3| 8| 8| 1| 4| 1| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Inflammation, Granulomatous | | 1 2.0|
Pigmentation, Hemosiderin | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 2 1 1 2| 48 1.1|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 3 4 3 3 3 3 3 4 3 4 4 3 3 4 3 3 4 3 4 3 3 3 3 3| 49 3.3|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 4 4 1 | 7 3.6|
Hyperplasia | 1 1 | 3 1.0|
Inflammation | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
Inflammation | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 2 3.0|
Hydrocephalus | | 1 3.0|
Inflammation | | 1 1.0|
Mineralization | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Granulomatous | 1 1 1 | 12 1.1|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 2| 3| 7| 7| 7| 4| 7| |
DAY ON TEST | 3| 3| 3| 2| 2| 3| 3| 3| 2| 3| 3| 9| 3| 3| 3| 2| 3| 4| 8| 5| 3| 2| 3| 3| 3| |
| 1| 1| 1| 4| 4| 0| 0| 1| 4| 0| 0| 7| 0| 0| 0| 9| 1| 3| 8| 8| 1| 4| 1| 0| 1| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Alveolar Epithelium, Hyperplasia | 2 1 4 1 1 1 2 1 2 1 1| 18 1.5|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 1| 50 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 2 2.5|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1| 1 1.0|
Lens, Cataract | 3| 1 3.0|
Retina, Degeneration | 1 4| 2 2.5|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphoid | 1 1 1 1 1 | 14 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 1 4.0|
Inflammation, Chronic Active | | 1 2.0|
Nephropathy | 1 1 1 1 1 1 1 2 1 1 2 1 1 1 1 1 2 1 1 1 1 1 1| 47 1.1|
Cortex, Mineralization | 1 | 2 1.0|
Medulla, Fibrosis | | 1 2.0|
Medulla, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 43 1.0|
Pelvis, Inflammation | | 1 3.0|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | | 1 1.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 5| 3| 1| 3| 3| 3| 3| 3| 3| 9| 9| 3| 3| 3|
| 0| 1| 1| 1| 1| 3| 1| 9| 5| 1| 0| 3| 1| 3| 0| 1| 0| 0| 0| 0| 3| 7| 0| 1| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
312 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Periesophageal Tissue, Necrosis, | |
Fatty | |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 1 |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 2 1 1 1 1 1|
Ulcer | |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X |
Eosinophilic Focus | X X X |
Fatty Change, Diffuse | 1 1 4 4 |
Hematopoietic Cell Proliferation | 1 1 1 2 1 |
Hepatodiaphragmatic Nodule | X X X X |
Inflammation, Chronic Active | 1 2 1 1 1 2 1 2 1 1 2 2 2 2 2 1 2 2 2|
Mixed Cell Focus | X X X X X X X|
Necrosis | 1 1 3 |
Bile Duct, Hyperplasia | 1 1 1 1 1 1 1 3 1 2 2 1 1 1 1 1 1 2 1|
Hepatocyte, Centrilobular, | |
Hypertrophy | 1 1 1 2 1 1 1 1 1 1 1 1|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 14
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 5| 3| 1| 3| 3| 3| 3| 3| 3| 9| 9| 3| 3| 3|
| 0| 1| 1| 1| 1| 3| 1| 9| 5| 1| 0| 3| 1| 3| 0| 1| 0| 0| 0| 0| 3| 7| 0| 1| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
312 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Mesentery | + + + + + + + + +|
Fat, Necrosis | 2 1 2 1 1 3 1 2 2|
|__________________________________________________________________________|
Oral Mucosa | + + |
Gingival, Inflammation | 1 1 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 |
Acinus, Atrophy | 1 1 1 1 1 1 1 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 3 |
Inflammation | 1 |
Ulcer | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 2 1 2 2 1 2 1 2 1 2 2 1 1 1 1 2 1 1 1|
Atrium, Thrombosis | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1|
Degeneration, Cystic | 1 |
Hematopoietic Cell Proliferation | |
Hyperplasia | 1 1 1 1 1 2 1 1 1|
Hypertrophy | 1 1 1 |
Necrosis | 1 1 |
__________________________________________|__________________________________________________________________________|
Page 15
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 5| 3| 1| 3| 3| 3| 3| 3| 3| 9| 9| 3| 3| 3|
| 0| 1| 1| 1| 1| 3| 1| 9| 5| 1| 0| 3| 1| 3| 0| 1| 0| 0| 0| 0| 3| 7| 0| 1| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
312 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Vacuolization Cytoplasmic | 2 1 1 1 1 1 1 3 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 3 1 4 1 3 1 2 3 1 4 1 2 1|
Cyst | |
Hyperplasia | 3 3 4 1 1 3 2 2 2 3 3|
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 4 1 1 1 |
Follicle, Hyperplasia | 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Hyperplasia | 2 |
Inflammation | 2 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X X |
Interstitial Cell, Hyperplasia | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic | 1 2 2 2 4 4 2 1 1 1 2 1|
Endometrium, Hyperplasia, Adenomatous| |
Serosa, Inflammation, Granulomatous | 1 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 16
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 5| 3| 1| 3| 3| 3| 3| 3| 3| 9| 9| 3| 3| 3|
| 0| 1| 1| 1| 1| 3| 1| 9| 5| 1| 0| 3| 1| 3| 0| 1| 0| 0| 0| 0| 3| 7| 0| 1| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
312 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Vagina | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | 2 |
Erythroid Cell, Hyperplasia | 1 1 1 1 |
Myeloid Cell, Hyperplasia | 3 3 2 4 2 4 |
|__________________________________________________________________________|
Lymph Node | + + + + + +|
Mediastinal, Infiltration Cellular, | |
Plasma Cell | |
Pancreatic, Hemorrhage | 2 2 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 2 2 3|
Pancreatic, Pigmentation, Hemosiderin| 3 3 |
Renal, Infiltration Cellular, | |
Histiocyte | 3 |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M M M M M M M + M M M M M M M M M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Plasma Cell | |
Infiltration Cellular, Histiocyte | 1 1 2 1 1 2 1 2 2 2 1 1 2 2 3 1 2 2 1 2 1 1 1 1|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1|
Hyperplasia, Lymphoid | 2 |
Inflammation, Granulomatous | 4 |
Pigmentation, Hemosiderin | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Lymphoid Follicle, Atrophy | 1 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + M + + + + +|
Atrophy | 3 4 3 4 3 4 3 4 3 4 3 4 4 4 4 3 4 3 4 4 3 3 4 3|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 17
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 5| 3| 1| 3| 3| 3| 3| 3| 3| 9| 9| 3| 3| 3|
| 0| 1| 1| 1| 1| 3| 1| 9| 5| 1| 0| 3| 1| 3| 0| 1| 0| 0| 0| 0| 3| 7| 0| 1| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
312 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
Galactocele | 4 |
Hyperplasia | 2 |
Inflammation | |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + |
Inflammation | 1 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 |
Inflammation | |
Necrosis | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 1|
Inflammation, Granulomatous | 1 1 1 |
Alveolar Epithelium, Hyperplasia | 1 2 1 1 1 1 2 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 2 2 1 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2 2|
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | + |
__________________________________________|__________________________________________________________________________|
Page 18
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 2| 2| 3| 3| 5| 3| 1| 3| 3| 3| 3| 3| 3| 9| 9| 3| 3| 3|
| 0| 1| 1| 1| 1| 3| 1| 9| 5| 1| 0| 3| 1| 3| 0| 1| 0| 0| 0| 0| 3| 7| 0| 1| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
312 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Lens, Cataract | |
Retina, Degeneration | 1 |
Retina, Dysplasia | |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphoid | 1 1 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | X |
Nephropathy | 2 1 2 1 1 1 2 1 2 1 1 1 1 1 2 2 1 1 2 2 1 1 1 1|
Cortex, Mineralization | 1 |
Medulla, Mineralization | 1 1 1 2 1 1 2 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2|
Pelvis, Transitional Epithelium, | |
Hyperplasia | 1 2 |
Renal Tubule, Hyperplasia | 4 |
Renal Tubule, Vacuolization | |
Cytoplasmic | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation | |
__________________________________________|__________________________________________________________________________
Page 19
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 9| 3| 3| 3| 3| 3| 2| 3| 1| 0| 3| 3| 3| 3| 2| 3| 9| 2| 1| 3| 3| 2| |
| 1| 1| 0| 7| 1| 1| 0| 1| 1| 9| 0| 0| 9| 1| 1| 0| 0| 9| 0| 0| 5| 3| 1| 0| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
312 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 2 | 1 2.0|
Periesophageal Tissue, Necrosis, | | |
Fatty | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | 1 | 3 1.0|
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | 1 | 8 1.1|
Ulcer | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 | 2 1.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X X X| 48 |
Clear Cell Focus | X X X X X X X X X| 13 |
Eosinophilic Focus | X X X | 6 |
Fatty Change, Diffuse | 1 2 3 1 | 8 2.1|
Hematopoietic Cell Proliferation | 1 | 6 1.2|
Hepatodiaphragmatic Nodule | X X | 6 |
Inflammation, Chronic Active | 1 1 2 2 1 2 1 2 2 1 1 1 2 2 1 1 2 1 1| 38 1.5|
Mixed Cell Focus | X X X X| 11 |
Necrosis | 1 1 1 | 6 1.3|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 9| 3| 3| 3| 3| 3| 2| 3| 1| 0| 3| 3| 3| 3| 2| 3| 9| 2| 1| 3| 3| 2| |
| 1| 1| 0| 7| 1| 1| 0| 1| 1| 9| 0| 0| 9| 1| 1| 0| 0| 9| 0| 0| 5| 3| 1| 0| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
312 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Bile Duct, Hyperplasia | 1 1 1 2 1 1 1 2 1 2 1 1 1 1 1 1 | 35 1.2|
Hepatocyte, Centrilobular, | | |
Hypertrophy | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 27 1.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + + + + | 18 |
Fat, Necrosis | 3 1 3 2 4 2 2 2 2 | 18 2.0|
|__________________________________________________________________________|____________|
Oral Mucosa | + + + + + + | 8 |
Gingival, Inflammation | 1 1 1 2 1 | 7 1.1|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1 | 3 1.0|
Acinus, Atrophy | 1 1 1 | 10 1.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Squamous | 2 | 2 2.5|
Inflammation | 2 | 2 1.5|
Ulcer | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 2 | 1 2.0|
Mineralization | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 2 1 2 1 2 1 2 2 1 2 1 1 1 2 1 2 1 1 1 1 2| 46 1.4|
Atrium, Thrombosis | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 9| 3| 3| 3| 3| 3| 2| 3| 1| 0| 3| 3| 3| 3| 2| 3| 9| 2| 1| 3| 3| 2| |
| 1| 1| 0| 7| 1| 1| 0| 1| 1| 9| 0| 0| 9| 1| 1| 0| 0| 9| 0| 0| 5| 3| 1| 0| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
312 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 1 1 2 1 1 1 1 2 1 1 1 1 1 1 1 1 1| 36 1.1|
Degeneration, Cystic | 1 | 2 1.0|
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Hyperplasia | 1 | 10 1.1|
Hypertrophy | 3 1 | 5 1.4|
Necrosis | 2 1 1 3 1 | 7 1.4|
Vacuolization Cytoplasmic | 1 1 1 3 1 2 2 1 | 16 1.4|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 1.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + + + + M + + + + + + + + + + +| 48 |
Hyperplasia | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 4 1 1 4 2 4 2 1 2 3 3 3 2 4 2 1| 30 2.3|
Cyst | 2 | 1 2.0|
Hyperplasia | 3 2 4 2 4 2 3 3 3 2 1 3 2| 24 2.5|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 2 3 1 2 3 1 | 11 1.8|
Follicle, Hyperplasia | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 3 | 2 2.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 9| 3| 3| 3| 3| 3| 2| 3| 1| 0| 3| 3| 3| 3| 2| 3| 9| 2| 1| 3| 3| 2| |
| 1| 1| 0| 7| 1| 1| 0| 1| 1| 9| 0| 0| 9| 1| 1| 0| 0| 9| 0| 0| 5| 3| 1| 0| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
312 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Hyperplasia | | 1 2.0|
Inflammation | 3 | 2 2.5|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X X X X X X| 13 |
Interstitial Cell, Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Endometrium, Hyperplasia, Cystic | 3 1 1 1 3 1 3 1 | 20 1.9|
Endometrium, Hyperplasia, Adenomatous| 3 | 1 3.0|
Serosa, Inflammation, Granulomatous | 1 | 2 1.0|
|__________________________________________________________________________|____________|
Vagina | + | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Granulomatous | | 1 2.0|
Erythroid Cell, Hyperplasia | 1 1 | 6 1.0|
Myeloid Cell, Hyperplasia | 3 3 1 2 2 2 1 | 13 2.5|
|__________________________________________________________________________|____________|
Lymph Node | + + | 8 |
Mediastinal, Infiltration Cellular, | | |
Plasma Cell | 2 | 1 2.0|
Pancreatic, Hemorrhage | | 2 2.0|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | | 3 2.3|
Pancreatic, Pigmentation, Hemosiderin| | 2 3.0|
Renal, Infiltration Cellular, | | |
Histiocyte | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M| 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 9| 3| 3| 3| 3| 3| 2| 3| 1| 0| 3| 3| 3| 3| 2| 3| 9| 2| 1| 3| 3| 2| |
| 1| 1| 0| 7| 1| 1| 0| 1| 1| 9| 0| 0| 9| 1| 1| 0| 0| 9| 0| 0| 5| 3| 1| 0| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
312 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Infiltration Cellular, Plasma Cell | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | 1 2 1 2 1 2 1 1 2 1 1 2 1 2 1 1 1 1 1 1 1 1 1 1 1| 49 1.4|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 45 1.0|
Hyperplasia, Lymphoid | | 1 2.0|
Inflammation, Granulomatous | | 1 4.0|
Pigmentation, Hemosiderin | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1| 50 1.0|
Lymphoid Follicle, Atrophy | 1 3 1 2 | 5 1.6|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 3 3 4 3 3 3 3 4 3 3 4 4 3 3 4 4 3 3 4 3 3 3 3 4| 48 3.4|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | 4 3 | 3 3.7|
Hyperplasia | 2 3 1 | 4 2.0|
Inflammation | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Inflammation | | 1 1.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | | 1 1.0|
Inflammation | 1 | 1 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 9| 3| 3| 3| 3| 3| 2| 3| 1| 0| 3| 3| 3| 3| 2| 3| 9| 2| 1| 3| 3| 2| |
| 1| 1| 0| 7| 1| 1| 0| 1| 1| 9| 0| 0| 9| 1| 1| 0| 0| 9| 0| 0| 5| 3| 1| 0| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
312 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
Necrosis | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | | 2 1.0|
Inflammation, Granulomatous | 1 1 | 5 1.0|
Alveolar Epithelium, Hyperplasia | 1 2 1 1 1 1 1 1 1 3 3| 18 1.4|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 50 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1 1 2 | 4 1.3|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | | 1 |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 3 | 1 3.0|
Lens, Cataract | 2 | 1 2.0|
Retina, Degeneration | 4 | 2 2.5|
Retina, Dysplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphoid | 1 1 1 | 10 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infarct | | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| |
DAY ON TEST | 3| 3| 3| 9| 3| 3| 3| 3| 3| 2| 3| 1| 0| 3| 3| 3| 3| 2| 3| 9| 2| 1| 3| 3| 2| |
| 1| 1| 0| 7| 1| 1| 0| 1| 1| 9| 0| 0| 9| 1| 1| 0| 0| 9| 0| 0| 5| 3| 1| 0| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| A |
312 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Nephropathy | 1 1 1 1 1 2 2 2 2 2 2 1 1 1 1 1 2 1 1 1 2 1 2 2 2| 49 1.4|
Cortex, Mineralization | | 1 1.0|
Medulla, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 2 1 1 1 1 1 1| 49 1.1|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | | 2 1.5|
Renal Tubule, Hyperplasia | | 1 4.0|
Renal Tubule, Vacuolization | | |
Cytoplasmic | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 1 3.0|
Inflammation | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 6| 3| 0| 3| 3| 4| 2| 3| 2| 3| 3| 3| 3| 9| 3| 3| 2| 3| 2| 3| 3|
| 8| 0| 1| 0| 2| 0| 9| 0| 1| 4| 9| 1| 9| 0| 0| 0| 0| 9| 1| 1| 9| 1| 9| 0| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
625 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 1 |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 1 1 2 1 1 X 1 2 |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 1 |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X |
Degeneration, Cystic | |
Eosinophilic Focus | X X X X |
Fatty Change, Diffuse | 2 3 |
Hematopoietic Cell Proliferation | 1 1 1 1 |
Hepatodiaphragmatic Nodule | X X X X |
Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 2 2 1 2 1 1 |
Mixed Cell Focus | X X|
Necrosis | 1 1 |
Bile Duct, Hyperplasia | 1 1 2 1 1 1 1 2 1 1 4 1 3 1 1 1 1 1 3 |
Hepatocyte, Centrilobular, | |
Hypertrophy | 1 1 2 2 2 1 2 1 1 1 1 1 2 1 2 1 1 2|
|__________________________________________________________________________|
Mesentery | + + + + + + |
Fat, Necrosis | 2 3 2 1 2 3 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 27
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 6| 3| 0| 3| 3| 4| 2| 3| 2| 3| 3| 3| 3| 9| 3| 3| 2| 3| 2| 3| 3|
| 8| 0| 1| 0| 2| 0| 9| 0| 1| 4| 9| 1| 9| 0| 0| 0| 0| 9| 1| 1| 9| 1| 9| 0| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
625 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Oral Mucosa | |
Gingival, Inflammation | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Inflammation | 1 |
Acinus, Atrophy | 1 1 1 2 1 1 1 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Basophilic Focus | |
Inflammation | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | |
Inflammation | 1 |
Ulcer | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Inflammation | 2 |
Mineralization | 1 |
Epithelium, Atrophy | 2 |
|__________________________________________________________________________|
Tooth | + |
Inflammation | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 1 1 1 1 2 2 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 1 1 1 1 1 1 1 1 |
__________________________________________|__________________________________________________________________________|
Page 28
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 6| 3| 0| 3| 3| 4| 2| 3| 2| 3| 3| 3| 3| 9| 3| 3| 2| 3| 2| 3| 3|
| 8| 0| 1| 0| 2| 0| 9| 0| 1| 4| 9| 1| 9| 0| 0| 0| 0| 9| 1| 1| 9| 1| 9| 0| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
625 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Degeneration, Cystic | |
Hematopoietic Cell Proliferation | 1 |
Hyperplasia | 4 1 1 4 1 1 |
Hypertrophy | 1 1 |
Necrosis | 1 2 |
Vacuolization Cytoplasmic | 2 2 1 1 4 1 1 2 1 1 1 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | M + + + + + + + M + + + + + + + + + + + + M + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 3 2 2 3 1 1 1 3 2 2 |
Cyst | |
Hyperplasia | 2 3 2 4 1 4 2 3 3 3 1 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 1 1 2 1 |
Follicle, Cyst | |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Cyst | 3 |
Hyperplasia | |
Inflammation | 3 3 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 29
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 6| 3| 0| 3| 3| 4| 2| 3| 2| 3| 3| 3| 3| 9| 3| 3| 2| 3| 2| 3| 3|
| 8| 0| 1| 0| 2| 0| 9| 0| 1| 4| 9| 1| 9| 0| 0| 0| 0| 9| 1| 1| 9| 1| 9| 0| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
625 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Endometrium, Hyperplasia, Cystic | 2 2 2 2 1 2 1 4 2 1 |
|__________________________________________________________________________|
Vagina | |
Inflammation | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | |
Myelofibrosis | |
Necrosis | |
Erythroid Cell, Hyperplasia | 2 3 2 |
Myeloid Cell, Hyperplasia | 2 2 4 3 2 3 3 |
|__________________________________________________________________________|
Lymph Node | + + + + + |
Axillary, Right, Ectasia | 3 |
Axillary, Right, Infiltration | |
Cellular, Plasma Cell | 4 |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | 3 2 |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 1 |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Plasma Cell | |
Infiltration Cellular, Histiocyte | 1 1 1 2 3 3 2 1 1 2 2 2 2 2 1 1 2 1 1 1 1 2 1 1 1|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | X|
Autolysis | |
Hematopoietic Cell Proliferation | 3 1 1 1 2 1 3 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Hyperplasia, Lymphoid | |
Pigmentation, Hemosiderin | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + M + + + M + + + +|
__________________________________________|__________________________________________________________________________|
Page 30
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 6| 3| 0| 3| 3| 4| 2| 3| 2| 3| 3| 3| 3| 9| 3| 3| 2| 3| 2| 3| 3|
| 8| 0| 1| 0| 2| 0| 9| 0| 1| 4| 9| 1| 9| 0| 0| 0| 0| 9| 1| 1| 9| 1| 9| 0| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
625 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Atrophy | 3 3 3 3 3 4 3 3 4 3 3 4 3 3 4 4 3 3 4 3 4 3|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 4 4 |
Hyperplasia | |
Inflammation | 2 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Subcutaneous Tissue, Necrosis | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Gliosis | |
Hemorrhage | |
Inflammation | 1 |
Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | |
Inflammation, Granulomatous | 2 1 1 |
Metaplasia, Squamous | |
Alveolar Epithelium, Hyperplasia | 1 1 1 2 1 1 1 2|
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2|
Interstitium, Fibrosis | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 31
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 5| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 2| 3| 3| 3| 6| 3| 0| 3| 3| 4| 2| 3| 2| 3| 3| 3| 3| 9| 3| 3| 2| 3| 2| 3| 3|
| 8| 0| 1| 0| 2| 0| 9| 0| 1| 4| 9| 1| 9| 0| 0| 0| 0| 9| 1| 1| 9| 1| 9| 0| 1|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
625 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 2 |
Thrombosis | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | + + |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 |
Lens, Cataract | 2 |
Retina, Degeneration | 4 2 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphoid | 1 1 1 1 1 |
|__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accumulation, Hyaline Droplet | 3 2 |
Infarct | X |
Nephropathy | 1 2 1 2 1 2 1 2 3 2 1 1 1 1 1 2 4 1 2 2 2 1 2 1 2|
Cortex, Mineralization | 1 |
Medulla, Mineralization | 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 1 2|
Pelvis, Inflammation | 2 2 1 |
Pelvis, Transitional Epithelium, | |
Hyperplasia | 2 2 |
Renal Tubule, Hyperplasia | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
__________________________________________|__________________________________________________________________________
Page 32
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 2| 3| 3| 7| 2| 0| 3| 3| 0| 3| 3| 0| 3| 2| 3| 3| 3| 3| 9| 3| 3| 3| 0| 2| |
| 1| 9| 0| 3| 9| 9| 9| 0| 1| 9| 0| 0| 4| 1| 8| 1| 0| 0| 0| 0| 1| 0| 1| 1| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
625 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | | 2 1.0|
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | 1 1 1 1 1 | 14 1.2|
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | | 1 1.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1 | 2 1.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 2 1 | 5 1.4|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X| 41 |
Clear Cell Focus | X X X X | 10 |
Degeneration, Cystic | 1 3 1 | 3 1.7|
Eosinophilic Focus | X X | 6 |
Fatty Change, Diffuse | 1 4 3 2 2 1 1 | 9 2.1|
Hematopoietic Cell Proliferation | | 4 1.0|
Hepatodiaphragmatic Nodule | X X | 6 |
Inflammation, Chronic Active | 1 1 1 2 1 1 1 2 2 1 1 1 1 2 2| 29 1.3|
Mixed Cell Focus | X X X | 5 |
Necrosis | 1 1 1 1 3 4 1 4 1 | 11 1.7|
Bile Duct, Hyperplasia | 1 1 1 2 1 2 3 2 2 1 1 1 1 1 2 1 1 1 1 2| 39 1.4|
Hepatocyte, Centrilobular, | | |
Hypertrophy | 1 1 1 1 1 1 1 2 1 2 1 2| 30 1.3|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 2| 3| 3| 7| 2| 0| 3| 3| 0| 3| 3| 0| 3| 2| 3| 3| 3| 3| 9| 3| 3| 3| 0| 2| |
| 1| 9| 0| 3| 9| 9| 9| 0| 1| 9| 0| 0| 4| 1| 8| 1| 0| 0| 0| 0| 1| 0| 1| 1| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
625 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Mesentery | + + + + | 10 |
Fat, Necrosis | 2 1 1 1 | 10 1.8|
|__________________________________________________________________________|____________|
Oral Mucosa | + + + + | 4 |
Gingival, Inflammation | 1 1 1 1 | 4 1.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 1 | 1 1.0|
Inflammation | 1 | 2 1.0|
Acinus, Atrophy | 1 2 4 1 | 11 1.5|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 1.0|
Basophilic Focus | 1 | 1 1.0|
Inflammation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Squamous | 2 2 | 2 2.0|
Inflammation | 2 | 2 1.5|
Ulcer | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | | 1 2.0|
Inflammation | 1 | 2 1.5|
Mineralization | 1 | 2 1.0|
Epithelium, Atrophy | | 1 2.0|
|__________________________________________________________________________|____________|
Tooth | + + | 3 |
Inflammation | 2 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 34
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 2| 3| 3| 7| 2| 0| 3| 3| 0| 3| 3| 0| 3| 2| 3| 3| 3| 3| 9| 3| 3| 3| 0| 2| |
| 1| 9| 0| 3| 9| 9| 9| 0| 1| 9| 0| 0| 4| 1| 8| 1| 0| 0| 0| 0| 1| 0| 1| 1| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
625 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 1 1 2 1 1 2 1 1 2 1 2 2 1 1 2 2 2 1 1 2 2 1 2 1| 48 1.3|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 1 1 1 1 1 1 1 | 18 1.0|
Degeneration, Cystic | 1 1 | 2 1.0|
Hematopoietic Cell Proliferation | 1 | 2 1.0|
Hyperplasia | | 6 2.0|
Hypertrophy | 1 1 1 | 5 1.0|
Necrosis | 2 1 1 | 5 1.4|
Vacuolization Cytoplasmic | 2 2 2 | 15 1.7|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 2 2.5|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + M + M + + + + + + + + + M + + + + + + + + + +| 44 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 4 2 4 3 1 2 4 2 3 2 2| 23 2.3|
Cyst | 1 | 1 1.0|
Hyperplasia | 3 3 1 2 2 4 4 4 4| 20 2.8|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 3 1 2 2 1 2 1 4 1 | 13 1.7|
Follicle, Cyst | 1 | 1 1.0|
Follicular Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 35
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 2| 3| 3| 7| 2| 0| 3| 3| 0| 3| 3| 0| 3| 2| 3| 3| 3| 3| 9| 3| 3| 3| 0| 2| |
| 1| 9| 0| 3| 9| 9| 9| 0| 1| 9| 0| 0| 4| 1| 8| 1| 0| 0| 0| 0| 1| 0| 1| 1| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
625 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 4.0|
Cyst | | 1 3.0|
Hyperplasia | 3 2 | 2 2.5|
Inflammation | | 2 3.0|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X X X X X | 10 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Endometrium, Hyperplasia, Cystic | 2 1 1 4 3 3 4 2 4 1 | 20 2.2|
|__________________________________________________________________________|____________|
Vagina | + | 1 |
Inflammation | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Granulomatous | 1 | 1 1.0|
Myelofibrosis | 1 2 | 2 1.5|
Necrosis | 2 | 1 2.0|
Erythroid Cell, Hyperplasia | 1 2 2 1 | 7 1.9|
Myeloid Cell, Hyperplasia | 2 2 4 4 3 3 4 1 2 1 2 1 2| 20 2.5|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + | 11 |
Axillary, Right, Ectasia | | 1 3.0|
Axillary, Right, Infiltration | | |
Cellular, Plasma Cell | | 1 4.0|
Mediastinal, Infiltration Cellular, | | |
Plasma Cell | 2 2 | 4 2.3|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | | 1 1.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 2| 3| 3| 7| 2| 0| 3| 3| 0| 3| 3| 0| 3| 2| 3| 3| 3| 3| 9| 3| 3| 3| 0| 2| |
| 1| 9| 0| 3| 9| 9| 9| 0| 1| 9| 0| 0| 4| 1| 8| 1| 0| 0| 0| 0| 1| 0| 1| 1| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
625 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Lymph Node, Mandibular | M M M M M + M M M M M M M M M M M M M M M M M M M| 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Plasma Cell | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | 2 2 1 1 1 1 1 1 2 2 1 2 1 1 2 2 1 1 1 3 2 1 1| 48 1.5|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Spleen | | 1 |
Autolysis | X X | 2 |
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 1 4 1 1 1 1 1 1 1 1 1| 40 1.2|
Hyperplasia, Lymphoid | 3 | 1 3.0|
Pigmentation, Hemosiderin | 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 49 1.0|
|__________________________________________________________________________|____________|
Thymus | + M + + + + + + M + + + + + + + + + + + + + + + +| 46 |
Atrophy | 3 3 4 4 4 3 3 3 3 4 4 4 3 3 3 3 4 3 4 4 3 4| 44 3.4|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | | 2 4.0|
Hyperplasia | 3 | 1 3.0|
Inflammation | | 1 2.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | 1 | 1 1.0|
Subcutaneous Tissue, Necrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 3 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 2| 3| 3| 7| 2| 0| 3| 3| 0| 3| 3| 0| 3| 2| 3| 3| 3| 3| 9| 3| 3| 3| 0| 2| |
| 1| 9| 0| 3| 9| 9| 9| 0| 1| 9| 0| 0| 4| 1| 8| 1| 0| 0| 0| 0| 1| 0| 1| 1| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
625 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Gliosis | 1 | 1 1.0|
Hemorrhage | 1 1 | 2 1.0|
Inflammation | | 1 1.0|
Necrosis | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | 2 | 1 2.0|
Inflammation, Granulomatous | 1 1 4 1 1 1 | 9 1.4|
Metaplasia, Squamous | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia | 1 1 1 1 1 | 13 1.2|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 2| 50 2.0|
Interstitium, Fibrosis | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1 | 3 1.3|
Thrombosis | 2 2 | 2 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | + | 3 |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 3 | 2 2.0|
Lens, Cataract | 1 | 2 1.5|
Retina, Degeneration | 3 3 | 4 3.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| |
DAY ON TEST | 3| 2| 3| 3| 7| 2| 0| 3| 3| 0| 3| 3| 0| 3| 2| 3| 3| 3| 3| 9| 3| 3| 3| 0| 2| |
| 1| 9| 0| 3| 9| 9| 9| 0| 1| 9| 0| 0| 4| 1| 8| 1| 0| 0| 0| 0| 1| 0| 1| 1| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| A |
625 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphoid | 1| 6 1.0|
|__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accumulation, Hyaline Droplet | | 2 2.5|
Infarct | 1 | 2 1.0|
Nephropathy | 2 1 2 1 2 2 2 1 2 3 2 2 1 2 1 1 1 1 1 2 4 2 3| 48 1.7|
Cortex, Mineralization | 1 1 1 | 4 1.0|
Medulla, Mineralization | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 49 1.1|
Pelvis, Inflammation | 2 | 4 1.8|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | | 2 2.0|
Renal Tubule, Hyperplasia | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 5| 7|
DAY ON TEST | 3| 3| 2| 3| 3| 3| 3| 2| 2| 3| 8| 0| 3| 2| 3| 3| 8| 3| 2| 3| 3| 8| 2| 8| 0|
| 8| 1| 9| 1| 1| 0| 1| 9| 9| 1| 6| 1| 0| 9| 1| 0| 7| 1| 8| 1| 1| 1| 9| 1| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 1 |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 1 1 |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X |
Degeneration, Cystic | 1 1 2 |
Eosinophilic Focus | X X X X |
Fatty Change, Diffuse | 1 1 1 1 2 1 1 1 4 1 1 1|
Fibrosis | |
Hematopoietic Cell Proliferation | 2 |
Hepatodiaphragmatic Nodule | X |
Inflammation, Chronic Active | 1 1 1 1 1 1 2 2 2 2 1 1 1 2 1|
Mixed Cell Focus | X X X |
Necrosis | 1 1 1 1 2 2 1 |
Bile Duct, Cyst | X |
Bile Duct, Hyperplasia | 2 3 1 1 1 1 2 2 1 1 1 2 1 2 3 3 2 1 3 1 1|
Hepatocyte, Centrilobular, | |
Hypertrophy | 2 2 2 2 3 2 3 1 2 2 2 2 2 2 1 2|
Oval Cell, Hyperplasia | 1 |
|__________________________________________________________________________|
Mesentery | + + + + + |
__________________________________________|__________________________________________________________________________|
Page 40
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 5| 7|
DAY ON TEST | 3| 3| 2| 3| 3| 3| 3| 2| 2| 3| 8| 0| 3| 2| 3| 3| 8| 3| 2| 3| 3| 8| 2| 8| 0|
| 8| 1| 9| 1| 1| 0| 1| 9| 9| 1| 6| 1| 0| 9| 1| 0| 7| 1| 8| 1| 1| 1| 9| 1| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Fat, Necrosis | 1 3 3 |
|__________________________________________________________________________|
Oral Mucosa | + + |
Hyperplasia, Squamous | |
Gingival, Inflammation | 1 1 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Inflammation | 1 1 |
Acinus, Atrophy | 1 1 1 1 1 4 1 1 1 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 1 1 |
Inflammation | 1 |
Ulcer | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Inflammation | 1 |
Ulcer | |
|__________________________________________________________________________|
Tooth | + |
Inflammation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 1 1 1 2 1 1 2 2 1 1 1 2 2 2 1 1 1 1 1 2 1 2|
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 41
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 5| 7|
DAY ON TEST | 3| 3| 2| 3| 3| 3| 3| 2| 2| 3| 8| 0| 3| 2| 3| 3| 8| 3| 2| 3| 3| 8| 2| 8| 0|
| 8| 1| 9| 1| 1| 0| 1| 9| 9| 1| 6| 1| 0| 9| 1| 0| 7| 1| 8| 1| 1| 1| 9| 1| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Atrophy | 2 |
Hematopoietic Cell Proliferation | 1 |
Hyperplasia | 1 1 1 1 |
Hypertrophy | 1 1 1 1 |
Necrosis | 2 |
Vacuolization Cytoplasmic | 1 1 2 1 1 1 1 2 2 1 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 1 1 2 4 4 3 2 2 2 2 1 1 3 1 2|
Cyst | 2 2 |
Hyperplasia | 3 2 2 1 1 2 4 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 2 1 3 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis, Focal | 2 |
__________________________________________|__________________________________________________________________________|
Page 42
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 5| 7|
DAY ON TEST | 3| 3| 2| 3| 3| 3| 3| 2| 2| 3| 8| 0| 3| 2| 3| 3| 8| 3| 2| 3| 3| 8| 2| 8| 0|
| 8| 1| 9| 1| 1| 0| 1| 9| 9| 1| 6| 1| 0| 9| 1| 0| 7| 1| 8| 1| 1| 1| 9| 1| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Inflammation | |
Cervix, Hypertrophy | 3 |
Endometrium, Hyperplasia, Cystic | 4 1 4 1 1 1 1 2 3 1 2 |
Endometrium, Hyperplasia, Adenomatous| |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | |
Myelofibrosis | 2 1 2 |
Necrosis | 2 |
Erythroid Cell, Hyperplasia | 1 |
Myeloid Cell, Hyperplasia | 3 3 3 1 2 4 3 2 2|
|__________________________________________________________________________|
Lymph Node | + + + + +|
Deep Cervical, Infiltration Cellular,| |
Plasma Cell | 2|
Mediastinal, Hemorrhage | |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | 2|
Mediastinal, Infiltration Cellular, | |
Histiocyte | 1|
Pancreatic, Infiltration Cellular, | |
Histiocyte | 2 |
Renal, Infiltration Cellular, | |
Histiocyte | 3 |
Renal, Pigmentation | 2 |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Plasma Cell | 1 |
Infiltration Cellular, Histiocyte | 3 1 1 2 1 1 1 1 1 1 1 3 3 1 1 1 1 1 1 2 1 3 1 1 2|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | |
Fibrosis | 1 |
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 1 2 1 2 2 1 1 1 1 2 1 1 1 1 1 1|
__________________________________________|__________________________________________________________________________|
Page 43
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 5| 7|
DAY ON TEST | 3| 3| 2| 3| 3| 3| 3| 2| 2| 3| 8| 0| 3| 2| 3| 3| 8| 3| 2| 3| 3| 8| 2| 8| 0|
| 8| 1| 9| 1| 1| 0| 1| 9| 9| 1| 6| 1| 0| 9| 1| 0| 7| 1| 8| 1| 1| 1| 9| 1| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Hyperplasia, Lymphoid | 4 |
Pigmentation, Hemosiderin | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Red Pulp, Hyperplasia | |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 4 3 3 3 3 4 4 3 3 3 4 3 3 3 4 3 3 4 3 3 4 3 4 4|
Cyst | 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Galactocele | 4 X |
Hyperplasia | 2 2 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Sebaceous Gland, Hyperplasia | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 |
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Necrosis | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | 2 1|
Alveolar Epithelium, Hyperplasia | 1 1 2 2 2 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
__________________________________________|__________________________________________________________________________|
Page 44
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 5| 7|
DAY ON TEST | 3| 3| 2| 3| 3| 3| 3| 2| 2| 3| 8| 0| 3| 2| 3| 3| 8| 3| 2| 3| 3| 8| 2| 8| 0|
| 8| 1| 9| 1| 1| 0| 1| 9| 9| 1| 6| 1| 0| 9| 1| 0| 7| 1| 8| 1| 1| 1| 9| 1| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Lens, Cataract | |
Optic Nerve, Fibrosis | 2 |
Retina, Degeneration | 3 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphoid | 1 1 1 1|
|__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accumulation, Hyaline Droplet | 4 |
Infarct | X |
Nephropathy | 2 2 3 3 2 2 1 2 1 3 1 3 4 1 2 2 1 2 1 1 2 1 2 2 2|
Cortex, Inflammation | |
Cortex, Mineralization | |
Medulla, Mineralization | 1 1 1 2 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1|
Pelvis, Inflammation | |
Pelvis, Transitional Epithelium, | |
Hyperplasia | 1 |
Renal Tubule, Cyst | |
Renal Tubule, Hyperplasia | |
Renal Tubule, Pigmentation | 2 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 45
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| |
DAY ON TEST | 1| 3| 3| 3| 2| 5| 7| 3| 3| 8| 3| 3| 2| 2| 3| 2| 3| 2| 3| 3| 5| 3| 3| 2| 7| |
| 4| 0| 1| 1| 9| 9| 9| 0| 0| 0| 0| 0| 4| 9| 0| 9| 1| 5| 1| 1| 3| 1| 1| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
1250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | 1 | 3 1.0|
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | 1 1 1 | 6 1.0|
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 | 1 1.0|
Basophilic Focus | X X X X X X X X X X X X X X X X X X X X X X X| 43 |
Clear Cell Focus | X X X X X X | 10 |
Degeneration, Cystic | 1 | 4 1.3|
Eosinophilic Focus | X X X X X | 9 |
Fatty Change, Diffuse | 1 1 1 1 3 1 2 3 | 20 1.5|
Fibrosis | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 1 | 2 1.5|
Hepatodiaphragmatic Nodule | X X X X X | 6 |
Inflammation, Chronic Active | 2 1 2 3 1 1 1 1 1 1 1 1 2 2 1| 30 1.4|
Mixed Cell Focus | X X | 5 |
Necrosis | 1 1 1 2 1 | 12 1.3|
Bile Duct, Cyst | | 1 |
Bile Duct, Hyperplasia | 4 1 2 2 1 1 2 1 3 1 1 1 1 2 1 2 1 1 2 | 40 1.6|
Hepatocyte, Centrilobular, | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 46
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| |
DAY ON TEST | 1| 3| 3| 3| 2| 5| 7| 3| 3| 8| 3| 3| 2| 2| 3| 2| 3| 2| 3| 3| 5| 3| 3| 2| 7| |
| 4| 0| 1| 1| 9| 9| 9| 0| 0| 0| 0| 0| 4| 9| 0| 9| 1| 5| 1| 1| 3| 1| 1| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
1250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Hypertrophy | 2 1 2 2 3 2 2 2 2 2 1 2 2 3 2 2 2 | 33 2.0|
Oval Cell, Hyperplasia | 1 4 | 3 2.0|
|__________________________________________________________________________|____________|
Mesentery | + | 6 |
Fat, Necrosis | 1 | 4 2.0|
|__________________________________________________________________________|____________|
Oral Mucosa | + + | 4 |
Hyperplasia, Squamous | 2 | 1 2.0|
Gingival, Inflammation | 1 2 | 4 1.3|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 1 | 1 1.0|
Inflammation | 1 1 1 1 | 6 1.0|
Acinus, Atrophy | 4 1 1 | 12 1.5|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Squamous | 3 4| 4 2.3|
Inflammation | 2 4| 3 2.3|
Ulcer | 4 3| 2 3.5|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | | 1 2.0|
Inflammation | 2 2| 3 1.7|
Ulcer | 3| 1 3.0|
|__________________________________________________________________________|____________|
Tooth | + + | 3 |
Inflammation | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| |
DAY ON TEST | 1| 3| 3| 3| 2| 5| 7| 3| 3| 8| 3| 3| 2| 2| 3| 2| 3| 2| 3| 3| 5| 3| 3| 2| 7| |
| 4| 0| 1| 1| 9| 9| 9| 0| 0| 0| 0| 0| 4| 9| 0| 9| 1| 5| 1| 1| 3| 1| 1| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
1250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
Mineralization | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 1 1 1 1 1 1 2 2 2 1 1 2 1 1 1 1 2 1 2 2 2 1| 46 1.4|
Atrium, Thrombosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 1 1 1 1 1 1 1 2 1 1 | 24 1.0|
Atrophy | | 1 2.0|
Hematopoietic Cell Proliferation | 1 | 2 1.0|
Hyperplasia | 2 1 | 6 1.2|
Hypertrophy | 1 1 1 1 | 8 1.0|
Necrosis | 3 | 2 2.5|
Vacuolization Cytoplasmic | 1 1 2 1 1 2 1 2 1 1 | 20 1.3|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + M + + + +| 48 |
Hyperplasia | 2| 1 2.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 4 1 2 2 2 1| 23 2.0|
Cyst | | 2 2.0|
Hyperplasia | 2 3 1 2 3 1 2 1 1 2| 18 1.9|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 2 4 1 1 1| 8 1.9|
Follicle, Cyst | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| |
DAY ON TEST | 1| 3| 3| 3| 2| 5| 7| 3| 3| 8| 3| 3| 2| 2| 3| 2| 3| 2| 3| 3| 5| 3| 3| 2| 7| |
| 4| 0| 1| 1| 9| 9| 9| 0| 0| 0| 0| 0| 4| 9| 0| 9| 1| 5| 1| 1| 3| 1| 1| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
1250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Squamous | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X X X X X X | 9 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis, Focal | | 1 2.0|
Inflammation | 2 | 1 2.0|
Cervix, Hypertrophy | | 1 3.0|
Endometrium, Hyperplasia, Cystic | 4 3 2 2 4 4 2 2 1 | 20 2.3|
Endometrium, Hyperplasia, Adenomatous| 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Granulomatous | 1 | 1 1.0|
Myelofibrosis | 1 2 1| 6 1.5|
Necrosis | | 1 2.0|
Erythroid Cell, Hyperplasia | 2 | 2 1.5|
Myeloid Cell, Hyperplasia | 2 2 4 3 | 13 2.6|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + | 12 |
Deep Cervical, Infiltration Cellular,| | |
Plasma Cell | 1 | 2 1.5|
Mediastinal, Hemorrhage | 3 3 | 2 3.0|
Mediastinal, Infiltration Cellular, | | |
Plasma Cell | 2 | 2 2.0|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | | 1 1.0|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
Renal, Infiltration Cellular, | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| |
DAY ON TEST | 1| 3| 3| 3| 2| 5| 7| 3| 3| 8| 3| 3| 2| 2| 3| 2| 3| 2| 3| 3| 5| 3| 3| 2| 7| |
| 4| 0| 1| 1| 9| 9| 9| 0| 0| 0| 0| 0| 4| 9| 0| 9| 1| 5| 1| 1| 3| 1| 1| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
1250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Histiocyte | | 1 3.0|
Renal, Pigmentation | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M + M M M M M M M M M M M M M M M M M M M M| 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Plasma Cell | 3 | 2 2.0|
Infiltration Cellular, Histiocyte | 1 1 1 1 3 2 1 3 2 1 1 2 1 1 1 1 1 1 1 2 1 1 1 3| 49 1.4|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Spleen | 2 | 1 2.0|
Fibrosis | | 1 1.0|
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1| 45 1.1|
Hyperplasia, Lymphoid | 1 | 2 2.5|
Pigmentation, Hemosiderin | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 49 1.0|
Red Pulp, Hyperplasia | 2| 1 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 4 3 3 3 3 4 4 3 3 3 3 4 3 3 4 3 4 3 4 3 3 3 3 4| 49 3.3|
Cyst | | 1 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 3.0|
Galactocele | | 2 4.0|
Hyperplasia | 2 | 3 2.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | X | 1 |
Sebaceous Gland, Hyperplasia | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| |
DAY ON TEST | 1| 3| 3| 3| 2| 5| 7| 3| 3| 8| 3| 3| 2| 2| 3| 2| 3| 2| 3| 3| 5| 3| 3| 2| 7| |
| 4| 0| 1| 1| 9| 9| 9| 0| 0| 0| 0| 0| 4| 9| 0| 9| 1| 5| 1| 1| 3| 1| 1| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
1250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 1| 2 1.0|
|__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Necrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Granulomatous | 3 1 1 1 1| 7 1.4|
Alveolar Epithelium, Hyperplasia | 1 1 1 1 1 1 1 2 1 | 15 1.3|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 2 2 2 1 2 2 2 1 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2| 50 1.9|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1 | 1 1.0|
Lens, Cataract | 4 3| 2 3.5|
Optic Nerve, Fibrosis | | 1 2.0|
Retina, Degeneration | 1 4 4| 4 3.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphoid | 1 1 1 2 1 | 9 1.1|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 6| 6| 7| 7| 4| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| |
DAY ON TEST | 1| 3| 3| 3| 2| 5| 7| 3| 3| 8| 3| 3| 2| 2| 3| 2| 3| 2| 3| 3| 5| 3| 3| 2| 7| |
| 4| 0| 1| 1| 9| 9| 9| 0| 0| 0| 0| 0| 4| 9| 0| 9| 1| 5| 1| 1| 3| 1| 1| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| A |
1250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accumulation, Hyaline Droplet | | 1 4.0|
Infarct | | 1 |
Nephropathy | 2 2 2 1 2 4 2 3 2 2 2 1 2 3 2 1 4 2 2 1 2 2 2 4| 49 2.0|
Cortex, Inflammation | 2 | 1 2.0|
Cortex, Mineralization | 1 | 1 1.0|
Medulla, Mineralization | 1 1 1 2 2 1 2 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1| 46 1.1|
Pelvis, Inflammation | 1 2 | 2 1.5|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | 1 1 1 | 4 1.0|
Renal Tubule, Cyst | X| 1 |
Renal Tubule, Hyperplasia | 4| 1 4.0|
Renal Tubule, Pigmentation | | 1 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 5| 7| 7| 5| 7| 5| 7| 6| 7| 4| 7| 6|
DAY ON TEST | 2| 2| 2| 3| 3| 3| 2| 3| 8| 2| 3| 4| 0| 4| 2| 2| 0| 2| 5| 2| 3| 0| 9| 0| 9|
| 9| 9| 6| 0| 0| 0| 9| 2| 0| 9| 0| 5| 9| 9| 9| 9| 6| 9| 3| 5| 8| 4| 5| 9| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X |
Clear Cell Focus | X X X X X X X X X |
Congestion | |
Degeneration, Cystic | 1 1 1 1|
Eosinophilic Focus | X X |
Fatty Change, Diffuse | 1 3 1 1 2 2 4 3 4 1|
Hematopoietic Cell Proliferation | 2 1 1 |
Hepatodiaphragmatic Nodule | X |
Inflammation, Chronic Active | 2 2 2 2 2 2 1 2 2 2 2 |
Inflammation, Granulomatous | 4 |
Mixed Cell Focus | X X X X |
Necrosis | 1 2 1 1 2 1 3 1 1|
Bile Duct, Hyperplasia | 2 2 3 1 2 1 1 2 2 2 3 3 2 1 2 2 1 2 2 2 1 2 3 2 3|
Hepatocyte, Multinucleated | 1 |
|__________________________________________________________________________|
Mesentery | + + + + + |
Inflammation | 2 |
Fat, Necrosis | 2 2 2 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 53
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 5| 7| 7| 5| 7| 5| 7| 6| 7| 4| 7| 6|
DAY ON TEST | 2| 2| 2| 3| 3| 3| 2| 3| 8| 2| 3| 4| 0| 4| 2| 2| 0| 2| 5| 2| 3| 0| 9| 0| 9|
| 9| 9| 6| 0| 0| 0| 9| 2| 0| 9| 0| 5| 9| 9| 9| 9| 6| 9| 3| 5| 8| 4| 5| 9| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Oral Mucosa | + |
Gingival, Inflammation | 1 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 1 1 2 4 |
Acinus, Atrophy | 2 1 1 1 2 1 1 1|
Acinus, Hyperplasia | 3 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + M + + + + + +|
Atrophy | |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 1 2 |
Inflammation | 1 |
Ulcer | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 1 2 1|
Inflammation | 1 4 |
Ulcer | |
|__________________________________________________________________________|
Tongue | |
|__________________________________________________________________________|
Tooth | + |
Inflammation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 1 3 2 1 2 2 1 1 3 3 2 3 1 1 3 2 2 2 2 2 2|
Atrium, Thrombosis | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
__________________________________________|__________________________________________________________________________|
Page 54
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 5| 7| 7| 5| 7| 5| 7| 6| 7| 4| 7| 6|
DAY ON TEST | 2| 2| 2| 3| 3| 3| 2| 3| 8| 2| 3| 4| 0| 4| 2| 2| 0| 2| 5| 2| 3| 0| 9| 0| 9|
| 9| 9| 6| 0| 0| 0| 9| 2| 0| 9| 0| 5| 9| 9| 9| 9| 6| 9| 3| 5| 8| 4| 5| 9| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Cytoplasmic Alteration | 2 |
Degeneration, Cystic | 1 |
Hematopoietic Cell Proliferation | 1 1 1 |
Hyperplasia | |
Hypertrophy | 1 2 1 2 1|
Necrosis | 4 |
Vacuolization Cytoplasmic | 3 1 1 1 1 2 2 2 1 3 1 2|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 4 4 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 1|
Cyst | 1 1 1 1 |
Hyperplasia | 2 4 1 2 3 1 4 1 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Mononuclear | |
Cell | 1 |
C-Cell, Hyperplasia | 1 1 3 1 1 1 4 3 1|
Follicle, Degeneration | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Peritoneum | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Coagulating Gland | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
__________________________________________|__________________________________________________________________________|
Page 55
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 5| 7| 7| 5| 7| 5| 7| 6| 7| 4| 7| 6|
DAY ON TEST | 2| 2| 2| 3| 3| 3| 2| 3| 8| 2| 3| 4| 0| 4| 2| 2| 0| 2| 5| 2| 3| 0| 9| 0| 9|
| 9| 9| 6| 0| 0| 0| 9| 2| 0| 9| 0| 5| 9| 9| 9| 9| 6| 9| 3| 5| 8| 4| 5| 9| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Inflammation | 1 3 2 |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Inflammation | 4 |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 3 |
Hyperplasia | 1 |
Inflammation | 1 1 1 1 2 2 1 1 3 1 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Inflammation | 3 |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Degeneration | 2 4 4 2|
Interstitial Cell, Hyperplasia | 1 2 1 3 1 3 2 1 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erythroid Cell, Hyperplasia | 2 2 2 2 2 2 2 1 2 |
Myeloid Cell, Hyperplasia | 3 4 4 2 2 2 3 2 4 3 3|
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + +|
Deep Cervical, Ectasia | 2 |
Deep Cervical, Infiltration Cellular,| |
Plasma Cell | |
Mediastinal, Ectasia | |
Mediastinal, Hemorrhage | |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 2 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 3 |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M + + M M M M M M + M M M M M + M M M|
Ectasia | 4 |
__________________________________________|__________________________________________________________________________|
Page 56
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 5| 7| 7| 5| 7| 5| 7| 6| 7| 4| 7| 6|
DAY ON TEST | 2| 2| 2| 3| 3| 3| 2| 3| 8| 2| 3| 4| 0| 4| 2| 2| 0| 2| 5| 2| 3| 0| 9| 0| 9|
| 9| 9| 6| 0| 0| 0| 9| 2| 0| 9| 0| 5| 9| 9| 9| 9| 6| 9| 3| 5| 8| 4| 5| 9| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 |
Ectasia | 2 1 4 |
Infiltration Cellular, Histiocyte | 1 1 1 2 2 1 1 1 1 2 1 1 1 1 1 1 1 2 1 1 1 1 1|
Inflammation | 4 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 1 1 1 1 1 2 1 2 1 1 2 2 3 2 1 1 1 2 1 1 1 1 2 1|
Hyperplasia, Lymphoid | 2 4 |
Inflammation, Granulomatous | 2 |
Necrosis | 2 |
Pigmentation, Hemosiderin | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 |
Lymphoid Follicle, Atrophy | 1 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + M + + + + + + + + + + +|
Atrophy | 2 4 4 2 3 4 4 3 4 3 4 4 4 4 4 4 4 4 4 4 4 4 3|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Galactocele | 1 |
Inflammation | 3 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + |
Degeneration | |
Inflammation | 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 57
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 5| 7| 7| 5| 7| 5| 7| 6| 7| 4| 7| 6|
DAY ON TEST | 2| 2| 2| 3| 3| 3| 2| 3| 8| 2| 3| 4| 0| 4| 2| 2| 0| 2| 5| 2| 3| 0| 9| 0| 9|
| 9| 9| 6| 0| 0| 0| 9| 2| 0| 9| 0| 5| 9| 9| 9| 9| 6| 9| 3| 5| 8| 4| 5| 9| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 3 2|
Necrosis | 2 2 |
|__________________________________________________________________________|
Peripheral Nerve | + |
Infiltration Cellular, Mononuclear | |
Cell | 1 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 1 |
Inflammation, Granulomatous | 1 |
Necrosis | |
Alveolar Epithelium, Hyperplasia | 1 1 1 1 1 2 2 1 1 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 1 2 2 2 2 2 2 1 2 2 1 2 1 2 2 2 1 2 2 2 2 1 2 1|
Bronchiole, Hyperplasia | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 1 2 2 2 |
Thrombosis | 2 |
Olfactory Epithelium, Degeneration | |
Olfactory Epithelium, Metaplasia | 2 |
Respiratory Epithelium, Hyperplasia | 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Iris, Fibrosis | 3 |
Iris, Inflammation | 1 |
Lens, Cataract | 3 3 |
Lens, Mineralization | 2 |
Retina, Atrophy | 2 |
__________________________________________|__________________________________________________________________________|
Page 58
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 6| 7| 5| 7| 7| 5| 7| 5| 7| 6| 7| 4| 7| 6|
DAY ON TEST | 2| 2| 2| 3| 3| 3| 2| 3| 8| 2| 3| 4| 0| 4| 2| 2| 0| 2| 5| 2| 3| 0| 9| 0| 9|
| 9| 9| 6| 0| 0| 0| 9| 2| 0| 9| 0| 5| 9| 9| 9| 9| 6| 9| 3| 5| 8| 4| 5| 9| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
Retina, Degeneration | 4 4 1 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Infiltration Cellular, Lymphoid | 1 2 1 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accumulation, Hyaline Droplet | 3 1 2 |
Infarct | 1 |
Nephropathy | 1 2 2 1 1 1 1 1 1 1 1 2 4 1 2 1 1 1 1 1 1 1 1 1 1|
Medulla, Mineralization | 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Pelvis, Transitional Epithelium, | |
Hyperplasia | 1 |
Renal Tubule, Hyperplasia | |
Renal Tubule, Pigmentation | 4 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 3 1 1 |
Muscularis, Degeneration | 1 |
__________________________________________|__________________________________________________________________________
Page 59
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 4| 7| 6| 7| 6| 7| 6| 5| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| |
DAY ON TEST | 2| 2| 8| 0| 7| 2| 6| 8| 2| 9| 2| 8| 2| 6| 2| 2| 2| 2| 3| 8| 3| 1| 2| 9| 7| |
| 5| 9| 0| 4| 6| 9| 6| 2| 9| 3| 9| 4| 9| 2| 9| 9| 9| 9| 4| 1| 0| 5| 9| 0| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | 1 1 1 1 1 | 6 1.0|
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X | 24 |
Clear Cell Focus | X X X X X X X X X X | 19 |
Congestion | 2 | 1 2.0|
Degeneration, Cystic | 1 1 3 1 | 8 1.3|
Eosinophilic Focus | X X X | 5 |
Fatty Change, Diffuse | 2 4 2 3 4 1 2 2 1 1 2 4| 22 2.3|
Hematopoietic Cell Proliferation | 1 | 4 1.3|
Hepatodiaphragmatic Nodule | X | 2 |
Inflammation, Chronic Active | 2 1 1 2 2 2 2 2 2 2 2 | 22 1.9|
Inflammation, Granulomatous | | 1 4.0|
Mixed Cell Focus | X X X X X | 9 |
Necrosis | 1 1 1 1 1 2 1 2 2 3| 19 1.5|
Bile Duct, Hyperplasia | 2 2 2 3 3 2 1 3 2 3 3 2 2 2 2 2 1 2 3 1 3 2 4 2| 49 2.1|
Hepatocyte, Multinucleated | | 1 1.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 60
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 4| 7| 6| 7| 6| 7| 6| 5| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| |
DAY ON TEST | 2| 2| 8| 0| 7| 2| 6| 8| 2| 9| 2| 8| 2| 6| 2| 2| 2| 2| 3| 8| 3| 1| 2| 9| 7| |
| 5| 9| 0| 4| 6| 9| 6| 2| 9| 3| 9| 4| 9| 2| 9| 9| 9| 9| 4| 1| 0| 5| 9| 0| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Mesentery | + + + + | 9 |
Inflammation | | 1 2.0|
Fat, Necrosis | 3 3 2 2 | 7 2.3|
|__________________________________________________________________________|____________|
Oral Mucosa | + + + + + + +| 8 |
Gingival, Inflammation | 1 1 1 1 1 1 1| 8 1.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 2 1 1 2 1 1 1 1 1 | 14 1.5|
Acinus, Atrophy | 1 4 2 1 1 1 1 1 1 1 1 1| 20 1.3|
Acinus, Hyperplasia | | 1 3.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Squamous | 2 3 2 2 2 | 7 2.0|
Inflammation | 2 2 2 2 2 3 2 | 8 2.0|
Ulcer | 1 3 3 3 | 4 2.5|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 2 1 | 5 1.4|
Inflammation | 2 2 2 | 5 2.2|
Ulcer | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Tongue | + | 1 |
|__________________________________________________________________________|____________|
Tooth | + + | 3 |
Inflammation | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 61
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 4| 7| 6| 7| 6| 7| 6| 5| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| |
DAY ON TEST | 2| 2| 8| 0| 7| 2| 6| 8| 2| 9| 2| 8| 2| 6| 2| 2| 2| 2| 3| 8| 3| 1| 2| 9| 7| |
| 5| 9| 0| 4| 6| 9| 6| 2| 9| 3| 9| 4| 9| 2| 9| 9| 9| 9| 4| 1| 0| 5| 9| 0| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 3 2 1 2 2 1 1 2 2 2 3 1 1 2 2 2 1 2 2 2 1 2 2 3| 48 1.9|
Atrium, Thrombosis | 3 3 | 3 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 1 1 1 | 4 1.0|
Cytoplasmic Alteration | | 1 2.0|
Degeneration, Cystic | | 1 1.0|
Hematopoietic Cell Proliferation | 1 1 | 5 1.0|
Hyperplasia | 1 | 1 1.0|
Hypertrophy | 1 1 2| 8 1.4|
Necrosis | | 1 4.0|
Vacuolization Cytoplasmic | 3 2 2 2 1 1 1 1 1 2 3 1 1 1 1 | 27 1.6|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 1 4 | 6 2.5|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 1 2 | 2 1.5|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 4 2.0|
Cyst | 1 1 | 6 1.0|
Hyperplasia | 1 3 2 1 3 1 2 2 | 16 2.1|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Mononuclear | | |
Cell | | 1 1.0|
C-Cell, Hyperplasia | 1 3 3 4 4 1 1 1 | 17 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 62
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 4| 7| 6| 7| 6| 7| 6| 5| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| |
DAY ON TEST | 2| 2| 8| 0| 7| 2| 6| 8| 2| 9| 2| 8| 2| 6| 2| 2| 2| 2| 3| 8| 3| 1| 2| 9| 7| |
| 5| 9| 0| 4| 6| 9| 6| 2| 9| 3| 9| 4| 9| 2| 9| 9| 9| 9| 4| 1| 0| 5| 9| 0| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Follicle, Degeneration | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Coagulating Gland | + | 1 |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | 1 | 1 1.0|
Inflammation | | 3 2.0|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 3.0|
Inflammation | 4 | 2 4.0|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 1 | 4 2.3|
Hyperplasia | 1 | 2 1.0|
Inflammation | 1 2 2 1 1 1 3 3 | 18 1.6|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 1 | 3 1.7|
Inflammation | | 1 3.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Germinal Epithelium, Degeneration | 1 4 | 6 2.8|
Interstitial Cell, Hyperplasia | 2 3 2 1 2 2 | 15 1.9|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 63
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 4| 7| 6| 7| 6| 7| 6| 5| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| |
DAY ON TEST | 2| 2| 8| 0| 7| 2| 6| 8| 2| 9| 2| 8| 2| 6| 2| 2| 2| 2| 3| 8| 3| 1| 2| 9| 7| |
| 5| 9| 0| 4| 6| 9| 6| 2| 9| 3| 9| 4| 9| 2| 9| 9| 9| 9| 4| 1| 0| 5| 9| 0| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Erythroid Cell, Hyperplasia | 2 2 1 2 | 13 1.8|
Myeloid Cell, Hyperplasia | 4 1 2 2 2 1 3 4 3 4| 21 2.8|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + +| 19 |
Deep Cervical, Ectasia | 2 | 2 2.0|
Deep Cervical, Infiltration Cellular,| | |
Plasma Cell | 2 | 1 2.0|
Mediastinal, Ectasia | 3 2 2 | 3 2.3|
Mediastinal, Hemorrhage | 1 | 1 1.0|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | 1 | 2 1.5|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M + M M M| 5 |
Ectasia | | 1 4.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 1.0|
Ectasia | 1 | 4 2.0|
Infiltration Cellular, Histiocyte | 1 1 1 1 1 2 1 2 1 2 1 2 1 1 2 1 1 1 1 1 1 1 2 1| 47 1.2|
Inflammation | | 1 4.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 1 2.0|
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 | 45 1.2|
Hyperplasia, Lymphoid | 2 1 2 1 | 6 2.0|
Inflammation, Granulomatous | | 1 2.0|
Necrosis | | 1 2.0|
Pigmentation, Hemosiderin | 1 1 1 1 1 3 1 1 2 1 1 1 1 1 1 1 1 1 1 | 39 1.1|
Lymphoid Follicle, Atrophy | | 1 1.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + M + + + + + +| 48 |
Atrophy | 3 3 4 3 4 3 4 4 4 4 4 3 4 3 4 3 3 3 4 4 4| 44 3.6|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 64
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 4| 7| 6| 7| 6| 7| 6| 5| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| |
DAY ON TEST | 2| 2| 8| 0| 7| 2| 6| 8| 2| 9| 2| 8| 2| 6| 2| 2| 2| 2| 3| 8| 3| 1| 2| 9| 7| |
| 5| 9| 0| 4| 6| 9| 6| 2| 9| 3| 9| 4| 9| 2| 9| 9| 9| 9| 4| 1| 0| 5| 9| 0| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | | 1 3.0|
Galactocele | 1 | 2 1.0|
Inflammation | | 1 3.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1 2 | 2 1.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
Degeneration | 2 | 1 2.0|
Inflammation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 1 2| 5 1.8|
Necrosis | | 2 2.0|
|__________________________________________________________________________|____________|
Peripheral Nerve | | 1 |
Infiltration Cellular, Mononuclear | | |
Cell | | 1 1.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | | 2 1.0|
Inflammation, Granulomatous | 1| 2 1.0|
Necrosis | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | 1 1 1 3 2 1 2 | 16 1.4|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 4| 7| 6| 7| 6| 7| 6| 5| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| |
DAY ON TEST | 2| 2| 8| 0| 7| 2| 6| 8| 2| 9| 2| 8| 2| 6| 2| 2| 2| 2| 3| 8| 3| 1| 2| 9| 7| |
| 5| 9| 0| 4| 6| 9| 6| 2| 9| 3| 9| 4| 9| 2| 9| 9| 9| 9| 4| 1| 0| 5| 9| 0| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 2 2 2 1 1 1 2 2 2 2 1 1 2 2 2 2 1 2 2 3 3| 46 1.7|
Bronchiole, Hyperplasia | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 2 3| 7 2.0|
Thrombosis | | 1 2.0|
Olfactory Epithelium, Degeneration | 1 | 1 1.0|
Olfactory Epithelium, Metaplasia | | 1 2.0|
Respiratory Epithelium, Hyperplasia | | 1 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Iris, Fibrosis | | 1 3.0|
Iris, Inflammation | | 1 1.0|
Lens, Cataract | | 2 3.0|
Lens, Mineralization | | 1 2.0|
Retina, Atrophy | | 1 2.0|
Retina, Degeneration | 1 1| 5 2.2|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 1 1.0|
Infiltration Cellular, Lymphoid | 1 1 2 1 1 | 9 1.2|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accumulation, Hyaline Droplet | 1 | 4 1.8|
Infarct | | 1 1.0|
Nephropathy | 2 2 2 1 1 2 2 1 2 2 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 50 1.3|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 4| 7| 6| 7| 6| 7| 6| 5| 7| 6| 7| 5| 7| 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| |
DAY ON TEST | 2| 2| 8| 0| 7| 2| 6| 8| 2| 9| 2| 8| 2| 6| 2| 2| 2| 2| 3| 8| 3| 1| 2| 9| 7| |
| 5| 9| 0| 4| 6| 9| 6| 2| 9| 3| 9| 4| 9| 2| 9| 9| 9| 9| 4| 1| 0| 5| 9| 0| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| A |
0 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Medulla, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1| 47 1.0|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | | 1 1.0|
Renal Tubule, Hyperplasia | 1 | 1 1.0|
Renal Tubule, Pigmentation | | 1 4.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 3 1.7|
Muscularis, Degeneration | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 5| 6| 7| 5| 5| 7| 6| 7| 7| 7|
DAY ON TEST | 2| 1| 1| 7| 3| 3| 2| 3| 1| 2| 9| 3| 3| 9| 2| 3| 9| 2| 2| 4| 3| 0| 2| 3| 0|
| 9| 5| 0| 3| 0| 0| 9| 0| 5| 9| 9| 0| 0| 8| 9| 5| 8| 9| 6| 3| 0| 9| 9| 0| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
312 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 1 2 |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | 3 |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X X X X X X X X X X X X |
Clear Cell Focus | X X X X X X X X X|
Degeneration, Cystic | 1 1 1 1 1 |
Eosinophilic Focus | X X X X X X X X|
Fatty Change, Diffuse | 1 2 3 1 3 1 1 1 1 |
Hematopoietic Cell Proliferation | |
Hepatodiaphragmatic Nodule | X |
Inflammation, Chronic Active | 2 1 1 1 2 2 2 2 |
Mixed Cell Focus | X X X X X X |
Necrosis | 1 1 2 1 2 3 1 3 |
Bile Duct, Cyst | |
Bile Duct, Hyperplasia | 1 1 2 2 3 3 3 3 2 1 2 2 2 3 2 1 2 2 2 2 2 2 2 |
Hepatocyte, Centrilobular, | |
Hypertrophy | 1 1 1 2 1 2 1 1 2 1|
|__________________________________________________________________________|
Mesentery | + + + + + + |
Fat, Necrosis | 2 2 3 1 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 68
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 5| 6| 7| 5| 5| 7| 6| 7| 7| 7|
DAY ON TEST | 2| 1| 1| 7| 3| 3| 2| 3| 1| 2| 9| 3| 3| 9| 2| 3| 9| 2| 2| 4| 3| 0| 2| 3| 0|
| 9| 5| 0| 3| 0| 0| 9| 0| 5| 9| 9| 0| 0| 8| 9| 5| 8| 9| 6| 3| 0| 9| 9| 0| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
312 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Oral Mucosa | + + + + |
Gingival, Inflammation | 1 1 1 |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Inflammation | 1 1 1 1 1 1 1 1 |
Acinus, Atrophy | 1 1 3 1 1 1 1 1 1 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Inflammation | 2 4 |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + A + + + + + + + + + + + + + +|
Autolysis | X |
Hyperplasia, Squamous | 2 2 1 |
Inflammation | 1 3 3 |
Mineralization | |
Ulcer | 1 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 3 |
Inflammation | 1 2 2 |
|__________________________________________________________________________|
Tongue | |
|__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 3 2 2 2 3 2 1 3 2 3 3 2 2 1 3 2 1 2 3 2 3 3 2|
Aorta, Tunic, Media, Mineralization | |
Atrium, Thrombosis | 2 |
Endocardium, Hyperplasia | 4 |
Valve, Thrombosis | |
__________________________________________|__________________________________________________________________________|
Page 69
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 5| 6| 7| 5| 5| 7| 6| 7| 7| 7|
DAY ON TEST | 2| 1| 1| 7| 3| 3| 2| 3| 1| 2| 9| 3| 3| 9| 2| 3| 9| 2| 2| 4| 3| 0| 2| 3| 0|
| 9| 5| 0| 3| 0| 0| 9| 0| 5| 9| 9| 0| 0| 8| 9| 5| 8| 9| 6| 3| 0| 9| 9| 0| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
312 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + A + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 |
Atrophy | |
Hyperplasia | 2 |
Hypertrophy | 1 |
Necrosis | |
Vacuolization Cytoplasmic | 3 2 1 1 2 2 1 2 1 2 2 1 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + A + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Hyperplasia | 4 1 1 1 3 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + A + + + + + + + + + + M + + + + + + + + + + +|
Hyperplasia | |
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 3 2 3 2 1 |
Cyst | 1 |
Hyperplasia | 1 3 2 2 1 3 1 1 3 4 1 |
Inflammation | 2 |
Pigmentation, Hemosiderin | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia | 4 1 1 |
Follicle, Cyst | 2 |
Follicle, Degeneration | 1 1 |
Follicular Cell, Hyperplasia | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Coagulating Gland | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 70
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 5| 6| 7| 5| 5| 7| 6| 7| 7| 7|
DAY ON TEST | 2| 1| 1| 7| 3| 3| 2| 3| 1| 2| 9| 3| 3| 9| 2| 3| 9| 2| 2| 4| 3| 0| 2| 3| 0|
| 9| 5| 0| 3| 0| 0| 9| 0| 5| 9| 9| 0| 0| 8| 9| 5| 8| 9| 6| 3| 0| 9| 9| 0| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
312 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Inflammation | |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 1 1 1 2|
Hyperplasia | |
Inflammation | 2 1 1 1 2 1 1 1 1 1 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 1 1 1 1|
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 4 |
Necrosis | 4 4 |
Germinal Epithelium, Degeneration | 4 4 |
Interstitial Cell, Hyperplasia | 2 3 3 1 3 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + A + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Megakaryocyte | |
Myelofibrosis | |
Necrosis | 2 |
Erythroid Cell, Hyperplasia | 1 |
Myeloid Cell, Hyperplasia | 3 3 2 3 3 4 2 2 4 2 1 4 1 2|
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + |
Deep Cervical, Infiltration Cellular,| |
Plasma Cell | |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | 2 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 2 |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________|__________________________________________________________________________|
Page 71
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 5| 6| 7| 5| 5| 7| 6| 7| 7| 7|
DAY ON TEST | 2| 1| 1| 7| 3| 3| 2| 3| 1| 2| 9| 3| 3| 9| 2| 3| 9| 2| 2| 4| 3| 0| 2| 3| 0|
| 9| 5| 0| 3| 0| 0| 9| 0| 5| 9| 9| 0| 0| 8| 9| 5| 8| 9| 6| 3| 0| 9| 9| 0| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
312 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 1 |
Infiltration Cellular, Histiocyte | 2 1 2 2 2 3 1 1 1 2 1 1 2 2 1 2 3 1 2 2 1|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Spleen | X |
Autolysis | X |
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 2 3|
Hyperplasia, Lymphoid | 2 2 |
Inflammation, Granulomatous | 3 3 |
Necrosis | |
Pigmentation, Hemosiderin | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 4 4 4 3 3 3 3 4 3 4 3 4 4 4 4 3 3 4 3 4 4|
Ectopic Parathyroid Gland | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + M + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
Subcutaneous Tissue, Inflammation | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skeletal Muscle | + |
Degeneration | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Necrosis | 2 |
__________________________________________|__________________________________________________________________________|
Page 72
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 5| 6| 7| 5| 5| 7| 6| 7| 7| 7|
DAY ON TEST | 2| 1| 1| 7| 3| 3| 2| 3| 1| 2| 9| 3| 3| 9| 2| 3| 9| 2| 2| 4| 3| 0| 2| 3| 0|
| 9| 5| 0| 3| 0| 0| 9| 0| 5| 9| 9| 0| 0| 8| 9| 5| 8| 9| 6| 3| 0| 9| 9| 0| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
312 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + A + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 3 1 |
Inflammation, Granulomatous | 3 1 3 |
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 1 3 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 1 1 2 2 1 1 1 1 2 1 1 1 1 1 2 2 1 3 2 2 1|
Bronchiole, Hyperplasia | 1 3 2 |
Interstitium, Fibrosis | 2 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 3 2 2 |
Thrombosis | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Retina, Degeneration | 1 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphoid | 1 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accumulation, Hyaline Droplet | 2 |
Infarct | X |
Nephropathy | 3 1 2 2 2 2 2 3 3 4 2 4 3 1 1 4 1 2 3 2|
Cortex, Mineralization | |
Medulla, Mineralization | 1 1 1 1 1 1 1 1 2 1 1 1 1 2 1 1 1 1 2 1 1 2 1 1|
Pelvis, Transitional Epithelium, | |
Hyperplasia | 1 1 1 1 1 |
Renal Tubule, Hyperplasia | 1 1 |
Renal Tubule, Pigmentation | |
__________________________________________|__________________________________________________________________________|
Page 73
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 4| 7| 7| 6| 7| 5| 6| 7| 5| 5| 7| 6| 7| 7| 7|
DAY ON TEST | 2| 1| 1| 7| 3| 3| 2| 3| 1| 2| 9| 3| 3| 9| 2| 3| 9| 2| 2| 4| 3| 0| 2| 3| 0|
| 9| 5| 0| 3| 0| 0| 9| 0| 5| 9| 9| 0| 0| 8| 9| 5| 8| 9| 6| 3| 0| 9| 9| 0| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
312 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | X |
__________________________________________|__________________________________________________________________________
Page 74
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| 3| 7| 7| 7| 6| |
DAY ON TEST | 2| 2| 2| 9| 2| 2| 2| 2| 3| 8| 7| 2| 4| 2| 2| 2| 3| 1| 2| 5| 4| 0| 2| 0| 5| |
| 9| 9| 9| 0| 9| 9| 9| 9| 0| 4| 3| 9| 1| 9| 9| 4| 0| 0| 9| 7| 4| 9| 9| 2| 3| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
312 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | 1| 1 1.0|
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | 1 1 1 | 6 1.2|
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Peyer's Patch, Hyperplasia, Lymphoid | | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 | 1 3.0|
Basophilic Focus | X X X X X X X X X X X X X | 25 |
Clear Cell Focus | X X X X X X X X X X | 19 |
Degeneration, Cystic | 1 1 1 1 1 1 | 11 1.0|
Eosinophilic Focus | X X X X X X | 14 |
Fatty Change, Diffuse | 1 1 2 4 1 2 2 1 1 2 3 | 20 1.7|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hepatodiaphragmatic Nodule | X X X X X | 6 |
Inflammation, Chronic Active | 2 1 1 2 1 2 2 1 2 2 2 1 2 | 21 1.6|
Mixed Cell Focus | X X X X X X X X X X X | 17 |
Necrosis | 1 3 1 2 1 1 1 3 1 1 2 | 19 1.6|
Bile Duct, Cyst | X | 1 |
Bile Duct, Hyperplasia | 1 1 2 3 3 2 2 3 1 4 2 2 2 2 3 2 2 1 2 1 2 2 3| 46 2.1|
Hepatocyte, Centrilobular, | | |
Hypertrophy | 1 2 1 1 1 1 2 | 17 1.3|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 75
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| 3| 7| 7| 7| 6| |
DAY ON TEST | 2| 2| 2| 9| 2| 2| 2| 2| 3| 8| 7| 2| 4| 2| 2| 2| 3| 1| 2| 5| 4| 0| 2| 0| 5| |
| 9| 9| 9| 0| 9| 9| 9| 9| 0| 4| 3| 9| 1| 9| 9| 4| 0| 0| 9| 7| 4| 9| 9| 2| 3| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
312 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Mesentery | + + + + + + | 12 |
Fat, Necrosis | 1 3 1 | 7 1.9|
|__________________________________________________________________________|____________|
Oral Mucosa | + + + + | 8 |
Gingival, Inflammation | 1 1 1 | 6 1.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 3 | 1 3.0|
Inflammation | 3 1 1 1 1 1 2 1| 16 1.2|
Acinus, Atrophy | 1 1 1 1 1 1 1 1 1 1 2 1| 21 1.1|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 | 1 1.0|
Inflammation | | 2 3.0|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Autolysis | | 1 |
Hyperplasia, Squamous | 2 | 4 1.8|
Inflammation | 2 1 2 | 6 2.0|
Mineralization | 1 | 1 1.0|
Ulcer | | 1 1.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 1 | 2 2.0|
Inflammation | 2 2 | 5 1.8|
|__________________________________________________________________________|____________|
Tongue | + | 1 |
|__________________________________________________________________________|____________|
Tooth | + + + + | 5 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 76
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| 3| 7| 7| 7| 6| |
DAY ON TEST | 2| 2| 2| 9| 2| 2| 2| 2| 3| 8| 7| 2| 4| 2| 2| 2| 3| 1| 2| 5| 4| 0| 2| 0| 5| |
| 9| 9| 9| 0| 9| 9| 9| 9| 0| 4| 3| 9| 1| 9| 9| 4| 0| 0| 9| 7| 4| 9| 9| 2| 3| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
312 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
Mineralization | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 3 2 1 1 2 2 1 1 1 1 2 3 2 2 1 2 2 2 2 2 2 3 2| 48 2.0|
Aorta, Tunic, Media, Mineralization | 1 | 1 1.0|
Atrium, Thrombosis | 2 2 4 1 | 5 2.2|
Endocardium, Hyperplasia | 4 | 2 4.0|
Valve, Thrombosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 1 1 | 4 1.3|
Atrophy | 3 | 1 3.0|
Hyperplasia | 1 1 1 | 4 1.3|
Hypertrophy | 1 | 2 1.0|
Necrosis | 1 1 1 4 | 4 1.8|
Vacuolization Cytoplasmic | 2 2 1 1 2 2 2 3 1 1 1 2 1 3 | 27 1.7|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 1 | 1 1.0|
Hyperplasia | 2 3 2 | 8 2.1|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + M + M + + + + + + + + + + + + + + + + M + + +| 45 |
Hyperplasia | 1| 1 1.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 2 2 1 | 10 2.0|
Cyst | 1 1 | 3 1.0|
Hyperplasia | 2 2 1 1 4 4 4 2 3 3 | 21 2.3|
Inflammation | | 1 2.0|
Pigmentation, Hemosiderin | 2 | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 77
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| 3| 7| 7| 7| 6| |
DAY ON TEST | 2| 2| 2| 9| 2| 2| 2| 2| 3| 8| 7| 2| 4| 2| 2| 2| 3| 1| 2| 5| 4| 0| 2| 0| 5| |
| 9| 9| 9| 0| 9| 9| 9| 9| 0| 4| 3| 9| 1| 9| 9| 4| 0| 0| 9| 7| 4| 9| 9| 2| 3| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
312 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia | 1 4 1 1 3 | 8 2.0|
Follicle, Cyst | | 1 2.0|
Follicle, Degeneration | | 2 1.0|
Follicular Cell, Hyperplasia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Coagulating Gland | + | 1 |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 3.0|
Inflammation | 3 2 | 2 2.5|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 | 7 1.1|
Hyperplasia | 1 1 2 | 3 1.3|
Inflammation | 1 1 1 1 1 1 2 | 17 1.2|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 | 7 1.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 1 4.0|
Necrosis | | 2 4.0|
Germinal Epithelium, Degeneration | 4 4 2 | 5 3.6|
Interstitial Cell, Hyperplasia | 3 2 2 3 3 2 | 12 2.3|
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 78
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| 3| 7| 7| 7| 6| |
DAY ON TEST | 2| 2| 2| 9| 2| 2| 2| 2| 3| 8| 7| 2| 4| 2| 2| 2| 3| 1| 2| 5| 4| 0| 2| 0| 5| |
| 9| 9| 9| 0| 9| 9| 9| 9| 0| 4| 3| 9| 1| 9| 9| 4| 0| 0| 9| 7| 4| 9| 9| 2| 3| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
312 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Megakaryocyte | 2 | 1 2.0|
Myelofibrosis | 2 | 1 2.0|
Necrosis | | 1 2.0|
Erythroid Cell, Hyperplasia | 1 2 | 3 1.3|
Myeloid Cell, Hyperplasia | 1 2 3 3 4 1 2 3 2 2 2 3 4| 27 2.5|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + +| 20 |
Deep Cervical, Infiltration Cellular,| | |
Plasma Cell | 2 2 | 2 2.0|
Mediastinal, Infiltration Cellular, | | |
Plasma Cell | | 1 2.0|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M + M M M M M M M M M| 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 1 | 2 1.0|
Infiltration Cellular, Histiocyte | 2 2 1 1 1 1 2 1 2 1 1 1 2 1 2 2 1 2 1 1| 41 1.5|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Spleen | | 1 |
Autolysis | | 1 |
Hematopoietic Cell Proliferation | 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1 2 1 2 1| 42 1.2|
Hyperplasia, Lymphoid | | 2 2.0|
Inflammation, Granulomatous | 3 | 3 3.0|
Necrosis | 3 2 | 2 2.5|
Pigmentation, Hemosiderin | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 43 1.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + M M + + + + + + + + +| 48 |
Atrophy | 3 3 4 4 3 4 3 4 3 4 3 4 3 4 4 4 4 4 4 4| 42 3.6|
Ectopic Parathyroid Gland | 3 | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 79
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| 3| 7| 7| 7| 6| |
DAY ON TEST | 2| 2| 2| 9| 2| 2| 2| 2| 3| 8| 7| 2| 4| 2| 2| 2| 3| 1| 2| 5| 4| 0| 2| 0| 5| |
| 9| 9| 9| 0| 9| 9| 9| 9| 0| 4| 3| 9| 1| 9| 9| 4| 0| 0| 9| 7| 4| 9| 9| 2| 3| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
312 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +| 48 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 2.0|
Subcutaneous Tissue, Inflammation | | 1 1.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skeletal Muscle | + | 2 |
Degeneration | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 1 4 1 1 | 5 1.8|
Necrosis | 1 2 2 | 4 1.8|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Acute | | 2 2.0|
Inflammation, Granulomatous | 2 | 4 2.3|
Thrombosis | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia | 1 2 3 | 5 2.0|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 2 2 2 2 2 2 1 1 1 1 1 2 1 1 2 1 2 2 1 1 1 3 2 1 1| 47 1.5|
Bronchiole, Hyperplasia | | 3 2.0|
Interstitium, Fibrosis | 1 | 2 1.5|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1 3 1 | 7 1.9|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6| 3| 7| 7| 7| 6| |
DAY ON TEST | 2| 2| 2| 9| 2| 2| 2| 2| 3| 8| 7| 2| 4| 2| 2| 2| 3| 1| 2| 5| 4| 0| 2| 0| 5| |
| 9| 9| 9| 0| 9| 9| 9| 9| 0| 4| 3| 9| 1| 9| 9| 4| 0| 0| 9| 7| 4| 9| 9| 2| 3| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| A |
312 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Thrombosis | 3 3 | 2 3.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 1 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Retina, Degeneration | 1 | 2 1.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Lymphoid | 1 1 | 4 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accumulation, Hyaline Droplet | | 1 2.0|
Infarct | X X| 3 |
Nephropathy | 3 3 3 2 4 3 2 4 1 1 1 4 2 3 3 1 4 2 3 1 1 3 4 1 2| 45 2.4|
Cortex, Mineralization | 1 | 1 1.0|
Medulla, Mineralization | 1 1 1 2 1 1 1 1 1 1 1 1 1 2 1 1 1 1 2 1 2 1 1 1 1| 49 1.2|
Pelvis, Transitional Epithelium, | | |
Hyperplasia | 2 2 1 1 1 1 | 11 1.2|
Renal Tubule, Hyperplasia | 3 1 1 | 5 1.4|
Renal Tubule, Pigmentation | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Calculus Gross Observation | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 81
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 6| 3| 9| 8| 2| 3| 3| 4| 2| 2| 0| 3| 2| 2| 2| 9| 2| 2| 0| 2| 2| 9| 3| 0| 2|
| 9| 0| 1| 7| 9| 0| 0| 3| 9| 9| 5| 0| 9| 9| 9| 0| 9| 6| 8| 9| 9| 4| 0| 8| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
625 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation | |
Parasite Metazoan | |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 1 1 |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X X X X X X|
Clear Cell Focus | X X X X X X X X X X X |
Degeneration, Cystic | 1 1 2 1 1 1 1 1 1 |
Eosinophilic Focus | X X X X X X |
Fatty Change, Diffuse | 1 1 1 1 1 1 2 2 3 2 1 2 |
Hematopoietic Cell Proliferation | 1 1 |
Hepatodiaphragmatic Nodule | X |
Inflammation, Chronic Active | 2 2 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 |
Mixed Cell Focus | X X X X X X X X X X X X |
Necrosis | 3 1 2 1 |
Bile Duct, Hyperplasia | 2 2 3 2 1 2 2 1 1 3 2 2 2 2 3 2 2 2 2 2 2 2 3 2|
Hepatocyte, Multinucleated | 1 |
Hepatocyte, Centrilobular, | |
Hypertrophy | 3 2 2 2 1 2 2 3 1 2 2 2 2 2 1 1 |
|__________________________________________________________________________|
Mesentery | + + |
Inflammation | |
__________________________________________|__________________________________________________________________________|
Page 82
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 6| 3| 9| 8| 2| 3| 3| 4| 2| 2| 0| 3| 2| 2| 2| 9| 2| 2| 0| 2| 2| 9| 3| 0| 2|
| 9| 0| 1| 7| 9| 0| 0| 3| 9| 9| 5| 0| 9| 9| 9| 0| 9| 6| 8| 9| 9| 4| 0| 8| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
625 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Fat, Necrosis | 2 3 |
|__________________________________________________________________________|
Oral Mucosa | + + +|
Gingival, Hyperplasia | |
Gingival, Inflammation | 2 1 2|
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 1 1 |
Acinus, Atrophy | 1 1 1 1 1 1 1 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 1 |
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 3 3 4 3 1 3|
Inflammation | 3 3 4 4 3 3|
Mineralization | 2 |
Ulcer | 3 3 4 4 2 2|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 3 |
Hyperplasia | |
Inflammation | 2 1 |
Mineralization | 3 4 3|
Ulcer | |
|__________________________________________________________________________|
Tooth | + + |
Inflammation | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Mineralization | 4 |
Pulmonary Artery, Pulmonary Vein, | |
Hypertrophy | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 83
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 6| 3| 9| 8| 2| 3| 3| 4| 2| 2| 0| 3| 2| 2| 2| 9| 2| 2| 0| 2| 2| 9| 3| 0| 2|
| 9| 0| 1| 7| 9| 0| 0| 3| 9| 9| 5| 0| 9| 9| 9| 0| 9| 6| 8| 9| 9| 4| 0| 8| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
625 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
Cardiomyopathy | 3 3 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 1 3 1 3|
Mineralization | 2 |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 2 |
Hematopoietic Cell Proliferation | 1 |
Hyperplasia | 1 2 1 1 1 1|
Hypertrophy | 1 1 4 |
Vacuolization Cytoplasmic | 2 1 1 1 1 2 1 1 1 1 1 1 1 2 1 2 1 1 3|
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 3 1 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + + + + + + + M + + + + + +|
Hyperplasia | 3 3 3 2 1 1 4 2 2 2|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 3 3 2 2 3 2 |
Cyst | 1 |
Hyperplasia | 3 3 1 2 2 3 1 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 1 |
C-Cell, Hyperplasia | 4 1 2 2 4 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
|__________________________________________________________________________|
Peritoneum | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Coagulating Gland | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 84
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 6| 3| 9| 8| 2| 3| 3| 4| 2| 2| 0| 3| 2| 2| 2| 9| 2| 2| 0| 2| 2| 9| 3| 0| 2|
| 9| 0| 1| 7| 9| 0| 0| 3| 9| 9| 5| 0| 9| 9| 9| 0| 9| 6| 8| 9| 9| 4| 0| 8| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
625 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
Inflammation | 1 2 |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 4 |
Inflammation | |
Duct, Cyst | |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 2 3 1 1 |
Hyperplasia | 1 4 1 1 |
Inflammation | 1 1 3 2 1 1 1 2 1 2 2|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 2 2 2 |
Inflammation | |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Degeneration | 2 1 2 1 |
Interstitial Cell, Hyperplasia | 2 2 1 2 3 1 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | 2 |
Myelofibrosis | |
Erythroid Cell, Hyperplasia | 1 1 2 1 2 2|
Myeloid Cell, Hyperplasia | 2 3 2 2 4 2 3 4 4 |
|__________________________________________________________________________|
Lymph Node | + + + + + +|
Mediastinal, Ectasia | 1 |
Mediastinal, Hemorrhage | |
Mediastinal, Hyperplasia | |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | 1 |
Mediastinal, Inflammation | 2 |
Pancreatic, Ectasia | 2 1 |
__________________________________________|__________________________________________________________________________|
Page 85
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 6| 3| 9| 8| 2| 3| 3| 4| 2| 2| 0| 3| 2| 2| 2| 9| 2| 2| 0| 2| 2| 9| 3| 0| 2|
| 9| 0| 1| 7| 9| 0| 0| 3| 9| 9| 5| 0| 9| 9| 9| 0| 9| 6| 8| 9| 9| 4| 0| 8| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
625 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Pancreatic, Hemorrhage | 2 |
Pancreatic, Infiltration Cellular, | |
Histiocyte | 3 3|
Pancreatic, Inflammation | 3 |
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M M M M + M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 1 1|
Infiltration Cellular, Histiocyte | 3 1 1 2 2 2 1 2 1 3 2 2 2 1 1 3 3 1 2 1 1 2 1 1|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 2 |
Hematopoietic Cell Proliferation | 1 1 2 1 1 1 1 1 2 2 1 1 1 1 1 1 1 1 1 2 1 2|
Hemorrhage | 1 |
Hyperplasia, Lymphoid | 3 3 2 4 3 |
Inflammation, Granulomatous | 4 3 3 4 |
Pigmentation, Hemosiderin | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Lymphoid Follicle, Atrophy | 2 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + M + + + + + + + + + + + + + +|
Atrophy | 4 4 4 4 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 3 4 3 4|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Galactocele | 1 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 2 |
Osteosclerosis | |
|__________________________________________________________________________|
Skeletal Muscle | + |
Degeneration | 2 |
__________________________________________|__________________________________________________________________________|
Page 86
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 6| 3| 9| 8| 2| 3| 3| 4| 2| 2| 0| 3| 2| 2| 2| 9| 2| 2| 0| 2| 2| 9| 3| 0| 2|
| 9| 0| 1| 7| 9| 0| 0| 3| 9| 9| 5| 0| 9| 9| 9| 0| 9| 6| 8| 9| 9| 4| 0| 8| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
625 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 1 |
Inflammation, Granulomatous | 4 |
Mineralization | 4 1|
Thrombosis | |
Alveolar Epithelium, Hyperplasia | 1 1 2 1 2 3 |
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 2 1 1 2 2 2 2 1 2 1 1 1 1 2 2 2 2 1 1 2 1 1 1|
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 3 2 3 1 |
Thrombosis | |
Olfactory Epithelium, Metaplasia | |
Respiratory Epithelium, Hyperplasia | 1 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ciliary Body, Inflammation | |
Iris, Fibrosis | 3 |
Lens, Cataract | 4 |
Retina, Degeneration | 1 4 1 2 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 |
Infiltration Cellular, Lymphoid | 1 1 1 1 1 |
|__________________________________________________________________________|
Lacrimal Gland | + |
__________________________________________|__________________________________________________________________________|
Page 87
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 6| 7| 6| 6| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 4| 7| 7| 7|
DAY ON TEST | 6| 3| 9| 8| 2| 3| 3| 4| 2| 2| 0| 3| 2| 2| 2| 9| 2| 2| 0| 2| 2| 9| 3| 0| 2|
| 9| 0| 1| 7| 9| 0| 0| 3| 9| 9| 5| 0| 9| 9| 9| 0| 9| 6| 8| 9| 9| 4| 0| 8| 9|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
625 PPM | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accumulation, Hyaline Droplet | 2 2 |
Hyperplasia, Oncocytic | |
Nephropathy | 4 4 4 3 3 3 4 3 4 4 4 3 3 4 3 2 4 4 4 2 4 2 4 4 4|
Cortex, Mineralization | 3 4 2|
Medulla, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1|
Pelvis, Inflammation | 1|
Pelvis, Transitional Epithelium, | |
Hyperplasia | 2 2 1 1 1 1 2 1 1 1 1 1 2 1 2 2 1|
Renal Tubule, Cyst | |
Renal Tubule, Hyperplasia | 1 4 1 1 2 1 1 1 |
Renal Tubule, Pigmentation | 3 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | |
Inflammation | 2 3|
__________________________________________|__________________________________________________________________________
Page 88
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 9| 2| 3| 2| 3| 2| 2| 3| 0| 1| 2| 2| 0| 3| 4| 8| 3| 3| 3| 3| 1| 2| 2| 2| 9| |
| 9| 9| 0| 4| 0| 9| 9| 0| 8| 3| 9| 9| 8| 0| 3| 6| 0| 0| 0| 0| 1| 9| 9| 9| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
625 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 2 | 1 2.0|
Inflammation | 2 | 1 2.0|
Parasite Metazoan | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | 1 1 X 1 1 | 8 1.0|
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X X X X X X X X X | 32 |
Clear Cell Focus | X X X X X X X | 18 |
Degeneration, Cystic | 1 1 1 1 1 1 3 1 1 1 3| 20 1.3|
Eosinophilic Focus | X X X X | 10 |
Fatty Change, Diffuse | 1 1 2 2 1 1 1 2 1 2| 22 1.5|
Hematopoietic Cell Proliferation | | 2 1.0|
Hepatodiaphragmatic Nodule | | 1 |
Inflammation, Chronic Active | 2 2 1 2 1 2 1 2 2 2 2 2 2 2 1 2 | 35 1.9|
Mixed Cell Focus | X X X X X X X X X X | 22 |
Necrosis | 2 1 2 2 1| 9 1.7|
Bile Duct, Hyperplasia | 1 2 2 1 2 1 2 2 3 2 2 1 3 3 2 2 2 2 4 3 2 2 2 3| 48 2.1|
Hepatocyte, Multinucleated | | 1 1.0|
Hepatocyte, Centrilobular, | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 89
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 9| 2| 3| 2| 3| 2| 2| 3| 0| 1| 2| 2| 0| 3| 4| 8| 3| 3| 3| 3| 1| 2| 2| 2| 9| |
| 9| 9| 0| 4| 0| 9| 9| 0| 8| 3| 9| 9| 8| 0| 3| 6| 0| 0| 0| 0| 1| 9| 9| 9| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
625 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Hypertrophy | 2 2 2 2 1 2 2 2 2 1 1 1 1 2 2 | 31 1.8|
|__________________________________________________________________________|____________|
Mesentery | + + + + + + | 8 |
Inflammation | 2 | 1 2.0|
Fat, Necrosis | 2 2 1 2 2 | 7 2.0|
|__________________________________________________________________________|____________|
Oral Mucosa | + + | 5 |
Gingival, Hyperplasia | 4 | 1 4.0|
Gingival, Inflammation | 2 2 | 5 1.8|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1 | 6 1.0|
Acinus, Atrophy | 1 1 2 2 1 2 2 1 1 2 1 3 1 1 1| 22 1.3|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 3 1.3|
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Squamous | 2 2 1 2 | 10 2.4|
Inflammation | 4 3 | 8 3.4|
Mineralization | | 1 2.0|
Ulcer | 4 3 | 8 3.1|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 |
Erosion | 1 1 | 3 1.7|
Hyperplasia | 2 | 1 2.0|
Inflammation | 2 2 | 4 1.8|
Mineralization | 1 2 | 5 2.6|
Ulcer | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Tooth | | 2 |
Inflammation | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 90
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 9| 2| 3| 2| 3| 2| 2| 3| 0| 1| 2| 2| 0| 3| 4| 8| 3| 3| 3| 3| 1| 2| 2| 2| 9| |
| 9| 9| 0| 4| 0| 9| 9| 0| 8| 3| 9| 9| 8| 0| 3| 6| 0| 0| 0| 0| 1| 9| 9| 9| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
625 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1 | 1 1.0|
Mineralization | | 1 4.0|
Pulmonary Artery, Pulmonary Vein, | | |
Hypertrophy | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 3 1 3 3 3 3 2 1 2 3 1 2 1 1 2 3 2 1 2 3 2 2 1| 47 2.1|
Mineralization | 1 | 2 1.5|
Atrium, Thrombosis | 1 2 | 2 1.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 2 1.5|
Hematopoietic Cell Proliferation | 1 | 2 1.0|
Hyperplasia | 1 1 1 2 1 | 11 1.2|
Hypertrophy | | 3 2.0|
Vacuolization Cytoplasmic | 1 1 2 1 1 2 2 2 1 2 1 1| 31 1.4|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 1 1 2 4 3 2| 11 2.1|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 1 1 1 1 4 3 2 1 1 | 19 2.0|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 3 1 1 3 | 11 2.2|
Cyst | | 1 1.0|
Hyperplasia | 3 1 1 1 1| 12 1.8|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 91
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 9| 2| 3| 2| 3| 2| 2| 3| 0| 1| 2| 2| 0| 3| 4| 8| 3| 3| 3| 3| 1| 2| 2| 2| 9| |
| 9| 9| 0| 4| 0| 9| 9| 0| 8| 3| 9| 9| 8| 0| 3| 6| 0| 0| 0| 0| 1| 9| 9| 9| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
625 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | 2 | 2 1.5|
C-Cell, Hyperplasia | 2 1 | 8 2.1|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
|__________________________________________________________________________|____________|
Peritoneum | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Coagulating Gland | + | 1 |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | 1 | 1 1.0|
Inflammation | 1 1 | 4 1.3|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 4.0|
Inflammation | 2 | 1 2.0|
Duct, Cyst | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 1 1 | 8 1.4|
Hyperplasia | | 4 1.8|
Inflammation | 2 1 1 1 2 1 2 1 1 1 2 2 4 1 1| 26 1.5|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 1 1 | 8 1.5|
Inflammation | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Germinal Epithelium, Degeneration | 2 4 | 6 2.0|
Interstitial Cell, Hyperplasia | 1 2 2 2 2 4 | 14 2.0|
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 92
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 9| 2| 3| 2| 3| 2| 2| 3| 0| 1| 2| 2| 0| 3| 4| 8| 3| 3| 3| 3| 1| 2| 2| 2| 9| |
| 9| 9| 0| 4| 0| 9| 9| 0| 8| 3| 9| 9| 8| 0| 3| 6| 0| 0| 0| 0| 1| 9| 9| 9| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
625 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Granulomatous | | 1 2.0|
Myelofibrosis | 2 2 | 2 2.0|
Erythroid Cell, Hyperplasia | 1 1 2 1 | 10 1.4|
Myeloid Cell, Hyperplasia | 3 3 1 3 2 4 3 1 3 3 4| 20 2.8|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + +| 16 |
Mediastinal, Ectasia | 1 2 2 | 4 1.5|
Mediastinal, Hemorrhage | 2 | 1 2.0|
Mediastinal, Hyperplasia | 2 | 1 2.0|
Mediastinal, Infiltration Cellular, | | |
Plasma Cell | 2 | 2 1.5|
Mediastinal, Inflammation | | 1 2.0|
Pancreatic, Ectasia | | 2 1.5|
Pancreatic, Hemorrhage | | 1 2.0|
Pancreatic, Infiltration Cellular, | | |
Histiocyte | | 2 3.0|
Pancreatic, Inflammation | 2 2 | 3 2.3|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M M M M M + M M M M M M M M M M M M| 2 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ectasia | 2 2 | 5 1.6|
Infiltration Cellular, Histiocyte | 2 2 1 1 1 2 2 2 2 1 2 2 1 1 1 2 2 1 3 1 1 1 2 2 | 48 1.6|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis | 3 2 | 3 2.3|
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 1 1 2 1 1 1| 45 1.2|
Hemorrhage | | 1 1.0|
Hyperplasia, Lymphoid | 1 3 4 1 | 9 2.7|
Inflammation, Granulomatous | 4 2 3 | 7 3.3|
Pigmentation, Hemosiderin | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 44 1.0|
Lymphoid Follicle, Atrophy | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 93
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 9| 2| 3| 2| 3| 2| 2| 3| 0| 1| 2| 2| 0| 3| 4| 8| 3| 3| 3| 3| 1| 2| 2| 2| 9| |
| 9| 9| 0| 4| 0| 9| 9| 0| 8| 3| 9| 9| 8| 0| 3| 6| 0| 0| 0| 0| 1| 9| 9| 9| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
625 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + M + + + + + + + + + + + +| 48 |
Atrophy | 4 2 3 3 4 4 4 4 4 4 3 3 4 4 4 4 4 4 4 4 4 4 4 4| 47 3.8|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Galactocele | | 1 1.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | | 1 2.0|
Osteosclerosis | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
Degeneration | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 2 3| 2 2.5|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | 1 1 2 | 5 1.2|
Inflammation, Granulomatous | 2 2 1 1 | 5 2.0|
Mineralization | | 2 2.5|
Thrombosis | 3 | 1 3.0|
Alveolar Epithelium, Hyperplasia | 3 1 2 1 1 2 1| 13 1.6|
Alveolus, Infiltration Cellular, | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 94
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 9| 2| 3| 2| 3| 2| 2| 3| 0| 1| 2| 2| 0| 3| 4| 8| 3| 3| 3| 3| 1| 2| 2| 2| 9| |
| 9| 9| 0| 4| 0| 9| 9| 0| 8| 3| 9| 9| 8| 0| 3| 6| 0| 0| 0| 0| 1| 9| 9| 9| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
625 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Histiocyte | 1 1 1 2 1 1 2 2 2 1 2 2 1 2 2 2 2 1 2 1 1 2 1 1 2| 49 1.5|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 2 1 1 | 8 1.9|
Thrombosis | 3 | 1 3.0|
Olfactory Epithelium, Metaplasia | 1 | 1 1.0|
Respiratory Epithelium, Hyperplasia | | 1 1.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1 1 1 1 1 | 8 1.0|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ciliary Body, Inflammation | 1 | 1 1.0|
Iris, Fibrosis | | 1 3.0|
Lens, Cataract | | 1 4.0|
Retina, Degeneration | 1| 5 1.8|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 1 3.0|
Infiltration Cellular, Lymphoid | 1 1 1 1 | 9 1.0|
|__________________________________________________________________________|____________|
Lacrimal Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accumulation, Hyaline Droplet | 1 1 | 4 1.5|
Hyperplasia, Oncocytic | 2 | 1 2.0|
Nephropathy | 2 4 4 4 3 4 4 4 4 4 4 3 4 4 2 1 3 2 1 2 3 3 4 4 1| 50 3.3|
Cortex, Mineralization | 1 | 4 2.5|
Medulla, Mineralization | 1 1 1 1 1 1 1 1 1 1 1 2 2 1 1 1 1 2 1 1 2 1 1 1 1| 47 1.1|
Pelvis, Inflammation | | 1 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 95
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 4| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 6| |
DAY ON TEST | 9| 2| 3| 2| 3| 2| 2| 3| 0| 1| 2| 2| 0| 3| 4| 8| 3| 3| 3| 3| 1| 2| 2| 2| 9| |
| 9| 9| 0| 4| 0| 9| 9| 0| 8| 3| 9| 9| 8| 0| 3| 6| 0| 0| 0| 0| 1| 9| 9| 9| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| A |
625 PPM | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Pelvis, Transitional Epithelium, | | |
Hyperplasia | 2 2 1 2 1 2 2 1 1 2 2 2 | 29 1.5|
Renal Tubule, Cyst | X | 1 |
Renal Tubule, Hyperplasia | 1 1 1 2 2 2 1 2 1 1 2 1 | 20 1.5|
Renal Tubule, Pigmentation | 3 | 2 3.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Calculus Gross Observation | X | 1 |
Inflammation | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 96
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 6| 5| 6| 6| 4| 6| 7| 5| 6| 5| 6| 5| 6| 6| 7| 5| 6| 5| 7| 6| 6| 6| 5| 6| 6|
DAY ON TEST | 9| 4| 2| 9| 8| 2| 0| 9| 3| 2| 0| 6| 3| 3| 0| 3| 4| 3| 2| 8| 3| 3| 0| 2| 0|
| 1| 9| 1| 4| 8| 1| 8| 3| 5| 9| 4| 9| 4| 7| 8| 7| 1| 7| 9| 1| 2| 4| 7| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Parasite Metazoan | 1 1 1 |
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 4|
Inflammation | 3 1 4|
Mineralization | 2 2|
Ulcer | |
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | X X X X X X X X X X X X|
Degeneration, Cystic | 1 1 1 1 1 1 |
Eosinophilic Focus | X X |
Fatty Change, Diffuse | 2 1 2 1 1 1 2 2 |
Hematopoietic Cell Proliferation | 1 |
Hepatodiaphragmatic Nodule | |
Infarct | X |
Inflammation, Chronic Active | 2 2 2 2 2 2 1 1 2 2 3 2 1 2 2 1 2 1 2|
Inflammation, Granulomatous | 2 3 |
Mineralization | 1 |
Mixed Cell Focus | X X X |
Necrosis | 2 2 2 2 |
Bile Duct, Hyperplasia | 1 1 1 2 1 1 1 2 1 1 1 1 2 3 1 1 1 2 2 1 1 1 2 1 1|
Hepatocyte, Centrilobular, | |
Hypertrophy | 2 1 2 1 1 2 1 2 2 1 1|
Hepatocyte, Centrilobular, Necrosis | |
Vein, Inflammation | 2 |
__________________________________________|__________________________________________________________________________|
Page 97
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 6| 5| 6| 6| 4| 6| 7| 5| 6| 5| 6| 5| 6| 6| 7| 5| 6| 5| 7| 6| 6| 6| 5| 6| 6|
DAY ON TEST | 9| 4| 2| 9| 8| 2| 0| 9| 3| 2| 0| 6| 3| 3| 0| 3| 4| 3| 2| 8| 3| 3| 0| 2| 0|
| 1| 9| 1| 4| 8| 1| 8| 3| 5| 9| 4| 9| 4| 7| 8| 7| 1| 7| 9| 1| 2| 4| 7| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Mesentery | + + + |
Inflammation | |
Fat, Necrosis | 2 2 2 |
|__________________________________________________________________________|
Oral Mucosa | + + + |
Gingival, Inflammation | 1 1 2 |
Pharyngeal, Inflammation | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 1 |
Inflammation | 1 1 1 1 |
Metaplasia, Hepatocyte | 1 |
Acinus, Atrophy | 2 1 1 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | 2 2 3 3 3 3 3 3 3 |
Inflammation | 2 4 2 2 3 3 4 |
Mineralization | 2 3 |
Ulcer | 3 4 1 3 4 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | 2 |
Inflammation | 1 |
Mineralization | 2 2 4 3 4 3 2 4 3|
Ulcer | 1 3 |
|__________________________________________________________________________|
Tongue | |
|__________________________________________________________________________|
Tooth | + + |
Inflammation | 1 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 3 2 3 4 3 4 2 1 4|
__________________________________________|__________________________________________________________________________|
Page 98
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 6| 5| 6| 6| 4| 6| 7| 5| 6| 5| 6| 5| 6| 6| 7| 5| 6| 5| 7| 6| 6| 6| 5| 6| 6|
DAY ON TEST | 9| 4| 2| 9| 8| 2| 0| 9| 3| 2| 0| 6| 3| 3| 0| 3| 4| 3| 2| 8| 3| 3| 0| 2| 0|
| 1| 9| 1| 4| 8| 1| 8| 3| 5| 9| 4| 9| 4| 7| 8| 7| 1| 7| 9| 1| 2| 4| 7| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 3 2 3 3 1 3 2 1 2 2 1 1 3 2 2 1 2 3 1 1 2 2 2 3 3|
Mineralization | 2 2 4 2 2|
Atrium, Thrombosis | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
Hyperplasia | 1 2 1 |
Hypertrophy | 1 |
Necrosis | |
Vacuolization Cytoplasmic | 1 1 2 1 1 2 1 2 1 2 2 |
|__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 3 2 2 3 3 2 1 1 2 2 1 3 1 3 2 2 3 1 4|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Cyst | 1 1 |
Hyperplasia | 1 4 2 1 |
Inflammation | 1 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ultimobranchial Cyst | 1 |
C-Cell, Hyperplasia | 1 |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 99
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 6| 5| 6| 6| 4| 6| 7| 5| 6| 5| 6| 5| 6| 6| 7| 5| 6| 5| 7| 6| 6| 6| 5| 6| 6|
DAY ON TEST | 9| 4| 2| 9| 8| 2| 0| 9| 3| 2| 0| 6| 3| 3| 0| 3| 4| 3| 2| 8| 3| 3| 0| 2| 0|
| 1| 9| 1| 4| 8| 1| 8| 3| 5| 9| 4| 9| 4| 7| 8| 7| 1| 7| 9| 1| 2| 4| 7| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | 1 |
Inflammation | 1 |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation | |
Duct, Cyst | |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 |
Inflammation | 1 2 3 1 1 1 1 3 1 1 1 2 2 2|
|__________________________________________________________________________|
Seminal Vesicle | + M + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 1 1 |
Inflammation | |
Mineralization | 1 3 3 |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1|
Germinal Epithelium, Degeneration | 4 4 2 |
Interstitial Cell, Hyperplasia | 3 2 1 2 1 2 2 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Granulomatous | 2 |
Myelofibrosis | 1 1 |
Erythroid Cell, Hyperplasia | 1 2 2 1 1 2 |
Myeloid Cell, Hyperplasia | 4 3 3 2 1 |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + +|
Deep Cervical, Ectasia | |
Deep Cervical, Infiltration Cellular,| |
Plasma Cell | 2 |
Mediastinal, Ectasia | 1 |
Mediastinal, Hemorrhage | 2 2 |
__________________________________________|__________________________________________________________________________|
Page 100
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 6| 5| 6| 6| 4| 6| 7| 5| 6| 5| 6| 5| 6| 6| 7| 5| 6| 5| 7| 6| 6| 6| 5| 6| 6|
DAY ON TEST | 9| 4| 2| 9| 8| 2| 0| 9| 3| 2| 0| 6| 3| 3| 0| 3| 4| 3| 2| 8| 3| 3| 0| 2| 0|
| 1| 9| 1| 4| 8| 1| 8| 3| 5| 9| 4| 9| 4| 7| 8| 7| 1| 7| 9| 1| 2| 4| 7| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Mediastinal, Hyperplasia | 2 2 |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | 2 2 |
Pancreatic, Ectasia | 1 3 |
Pancreatic, Hemorrhage | 1 |
Pancreatic, Inflammation | 3 |
Renal, Ectasia | 2 |
Renal, Infiltration Cellular, | |
Histiocyte | 3|
|__________________________________________________________________________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M|
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 1 2 3 2 |
Ectasia | 2 |
Infiltration Cellular, Histiocyte | 1 1 1 1 2 1 1 1 1 2 1 1 3 1 2 1 1 1 1 1 1 1 2 3|
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 1 1 2 1 1 2 1 1 1 1 1 1 1|
Hemorrhage | |
Hyperplasia, Lymphoid | 1 3 2 |
Inflammation, Granulomatous | 4 |
Necrosis | |
Pigmentation, Hemosiderin | 1 1 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1 1 1 1|
Lymphoid Follicle, Atrophy | 3 2 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + M + + + M + + + + + +|
Atrophy | 4 4 4 4 2 4 4 3 4 3 4 3 4 4 4 4 4 4 4 4 4 4 4|
Ectopic Parathyroid Gland | 1 1 1 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 101
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 6| 5| 6| 6| 4| 6| 7| 5| 6| 5| 6| 5| 6| 6| 7| 5| 6| 5| 7| 6| 6| 6| 5| 6| 6|
DAY ON TEST | 9| 4| 2| 9| 8| 2| 0| 9| 3| 2| 0| 6| 3| 3| 0| 3| 4| 3| 2| 8| 3| 3| 0| 2| 0|
| 1| 9| 1| 4| 8| 1| 8| 3| 5| 9| 4| 9| 4| 7| 8| 7| 1| 7| 9| 1| 2| 4| 7| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
MUSCULOSKELETAL SYSTEM - cont | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrous Osteodystrophy | 1 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 1 2 1 1 |
Inflammation, Granulomatous | 3 |
Metaplasia, Squamous | 1 |
Mineralization | 2 3 2 3 3 2 4 3|
Alveolar Epithelium, Hyperplasia | 2 1 1 2 1 1|
Alveolus, Infiltration Cellular, | |
Histiocyte | 2 1 2 2 2 1 2 1 2 2 2 1 2 2 2 1 2 2 1 2 2 2 2 2 2|
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 2 2 2 1|
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Anterior Chamber, Inflammation | 3|
Cornea, Inflammation | 1 |
Iris, Inflammation | 2 |
|__________________________________________________________________________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Infiltration Cellular, Lymphoid | 1 1 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 102
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
_____________________________________________________________________________________________________________________
| 6| 5| 6| 6| 4| 6| 7| 5| 6| 5| 6| 5| 6| 6| 7| 5| 6| 5| 7| 6| 6| 6| 5| 6| 6|
DAY ON TEST | 9| 4| 2| 9| 8| 2| 0| 9| 3| 2| 0| 6| 3| 3| 0| 3| 4| 3| 2| 8| 3| 3| 0| 2| 0|
| 1| 9| 1| 4| 8| 1| 8| 3| 5| 9| 4| 9| 4| 7| 8| 7| 1| 7| 9| 1| 2| 4| 7| 4| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
1250 PPM | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accumulation, Hyaline Droplet | 4 |
Nephropathy | 4 4 4 4 4 4 4 4 4 3 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4|
Artery, Inflammation | 2 |
Cortex, Mineralization | 3 2 4 2 4 4 1 4 4|
Medulla, Mineralization | 1 1 1 2 2 2 1 1 1 2 1 1 2 1 1 1 1 1 1 1 2 1 1 1 2|
Papilla, Transitional Epithelium, | |
Hyperplasia | |
Pelvis, Inflammation | 2 |
Pelvis, Transitional Epithelium, | |
Hyperplasia | 2 2 2 2 2 1 1 1 2 1 1 1 3 1 2 1 1 1|
Renal Tubule, Cyst | X X X X X X|
Renal Tubule, Hyperplasia | 1 1 1 1 2 1 1 2 1 1 1 1 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
__________________________________________|__________________________________________________________________________
Page 103
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 7| 6| 5| 5| 7| 7| 7| 6| 6| 5| 5| 6| 6| 6| 7| 6| 6| 6| 4| 5| 6| 5| |
DAY ON TEST | 2| 3| 5| 2| 2| 5| 9| 2| 0| 0| 7| 8| 2| 8| 0| 1| 1| 0| 3| 6| 6| 8| 6| 4| 4| |
| 9| 9| 3| 9| 4| 5| 3| 6| 8| 8| 5| 0| 9| 2| 1| 3| 7| 8| 4| 9| 2| 7| 9| 1| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
1250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Parasite Metazoan | 1 1 | 5 1.0|
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | | 1 4.0|
Inflammation | 4 | 4 3.0|
Mineralization | | 2 2.0|
Ulcer | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | X X X X X X X | 19 |
Degeneration, Cystic | 1 1 3 1 1 1 2 1 1 | 15 1.2|
Eosinophilic Focus | X X X X X X X | 9 |
Fatty Change, Diffuse | 1 2 2 2 1 3 3| 15 1.7|
Hematopoietic Cell Proliferation | 1 1 1 | 4 1.0|
Hepatodiaphragmatic Nodule | X | 1 |
Infarct | | 1 |
Inflammation, Chronic Active | 1 2 2 2 2 3 2 2 1 3 1 2 2 2 | 33 1.8|
Inflammation, Granulomatous | | 2 2.5|
Mineralization | | 1 1.0|
Mixed Cell Focus | X | 4 |
Necrosis | 2 1 1 2 1 3 1 1 2 2| 14 1.7|
Bile Duct, Hyperplasia | 1 3 2 1 2 1 2 1 3 2 2 1 2 2 1 2 1 3 2 1 2 2 1 2 2| 50 1.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 104
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 7| 6| 5| 5| 7| 7| 7| 6| 6| 5| 5| 6| 6| 6| 7| 6| 6| 6| 4| 5| 6| 5| |
DAY ON TEST | 2| 3| 5| 2| 2| 5| 9| 2| 0| 0| 7| 8| 2| 8| 0| 1| 1| 0| 3| 6| 6| 8| 6| 4| 4| |
| 9| 9| 3| 9| 4| 5| 3| 6| 8| 8| 5| 0| 9| 2| 1| 3| 7| 8| 4| 9| 2| 7| 9| 1| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
1250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Hepatocyte, Centrilobular, | | |
Hypertrophy | 1 2 1 1 3 1 2 2 | 19 1.5|
Hepatocyte, Centrilobular, Necrosis | 1 | 1 1.0|
Vein, Inflammation | | 1 2.0|
|__________________________________________________________________________|____________|
Mesentery | + | 4 |
Inflammation | 1 | 1 1.0|
Fat, Necrosis | | 3 2.0|
|__________________________________________________________________________|____________|
Oral Mucosa | + + + + | 7 |
Gingival, Inflammation | 1 1 | 5 1.2|
Pharyngeal, Inflammation | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | 1 1 | 3 1.0|
Inflammation | 1 1 1 1 1 | 9 1.0|
Metaplasia, Hepatocyte | | 1 1.0|
Acinus, Atrophy | 1 1 1 2 1 1 1 | 10 1.2|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + M + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Squamous | 2 3 3 3 3 3 1 1| 17 2.6|
Inflammation | 2 2 3 2 2 | 12 2.6|
Mineralization | 3 | 3 2.7|
Ulcer | 1 4 4 | 8 3.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 1 4 | 3 2.3|
Inflammation | 2 1 2 3 2 1 | 7 1.7|
Mineralization | 2 3 3 1 3 1 | 15 2.7|
Ulcer | 1 4 | 4 2.3|
|__________________________________________________________________________|____________|
Tongue | + | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 105
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 7| 6| 5| 5| 7| 7| 7| 6| 6| 5| 5| 6| 6| 6| 7| 6| 6| 6| 4| 5| 6| 5| |
DAY ON TEST | 2| 3| 5| 2| 2| 5| 9| 2| 0| 0| 7| 8| 2| 8| 0| 1| 1| 0| 3| 6| 6| 8| 6| 4| 4| |
| 9| 9| 3| 9| 4| 5| 3| 6| 8| 8| 5| 0| 9| 2| 1| 3| 7| 8| 4| 9| 2| 7| 9| 1| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
1250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Tooth | + | 3 |
Inflammation | | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 4 4 | 11 3.1|
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy | 2 2 1 1 3 2 2 2 1 2 1 3 1 2 1 2 2 2 3 2 1 1 2 1| 49 1.9|
Mineralization | 2 | 6 2.3|
Atrium, Thrombosis | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 1.0|
Hyperplasia | 1 | 4 1.3|
Hypertrophy | 1 1 | 3 1.0|
Necrosis | 1 | 1 1.0|
Vacuolization Cytoplasmic | 1 1 2 1 2 2 3 1 1 1 2 1 1 1 1 2| 27 1.4|
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 3 1 3 | 5 1.8|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| 49 |
Hyperplasia | 1 1 1 3 4 2 3 4 2 1 1 3 2 | 32 2.2|
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 1 | 3 1.7|
Cyst | 1 1 1| 5 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 106
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 7| 6| 5| 5| 7| 7| 7| 6| 6| 5| 5| 6| 6| 6| 7| 6| 6| 6| 4| 5| 6| 5| |
DAY ON TEST | 2| 3| 5| 2| 2| 5| 9| 2| 0| 0| 7| 8| 2| 8| 0| 1| 1| 0| 3| 6| 6| 8| 6| 4| 4| |
| 9| 9| 3| 9| 4| 5| 3| 6| 8| 8| 5| 0| 9| 2| 1| 3| 7| 8| 4| 9| 2| 7| 9| 1| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
1250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Hyperplasia | 1 2 2 2 2 1 4 1 1 | 13 1.8|
Inflammation | | 1 1.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ultimobranchial Cyst | | 1 1.0|
C-Cell, Hyperplasia | 1 2 1 2 | 5 1.4|
Follicular Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Granuloma Sperm | 2 | 2 1.5|
Inflammation | | 1 1.0|
|__________________________________________________________________________|____________|
Preputial Gland | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | 2 | 1 2.0|
Inflammation | 2 | 1 2.0|
Duct, Cyst | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 1 2 | 4 1.3|
Inflammation | 3 1 1 1 2 1 2 1 1 2 1 3 | 26 1.6|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | 1 2 | 4 1.3|
Inflammation | 2 | 1 2.0|
Mineralization | 4 | 4 2.8|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | | 1 1.0|
Germinal Epithelium, Degeneration | 1 1 4 4 | 7 2.9|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 107
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 7| 6| 5| 5| 7| 7| 7| 6| 6| 5| 5| 6| 6| 6| 7| 6| 6| 6| 4| 5| 6| 5| |
DAY ON TEST | 2| 3| 5| 2| 2| 5| 9| 2| 0| 0| 7| 8| 2| 8| 0| 1| 1| 0| 3| 6| 6| 8| 6| 4| 4| |
| 9| 9| 3| 9| 4| 5| 3| 6| 8| 8| 5| 0| 9| 2| 1| 3| 7| 8| 4| 9| 2| 7| 9| 1| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
1250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Interstitial Cell, Hyperplasia | 1 3 2 2 2 2 1 1 4 2 1 1 | 22 1.9|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Granulomatous | 2 | 2 2.0|
Myelofibrosis | | 2 1.0|
Erythroid Cell, Hyperplasia | 1 1 4 2 | 10 1.7|
Myeloid Cell, Hyperplasia | 2 2 3 2 2 4 3 4 3| 14 2.7|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + +| 19 |
Deep Cervical, Ectasia | 2 | 1 2.0|
Deep Cervical, Infiltration Cellular,| | |
Plasma Cell | 1 | 2 1.5|
Mediastinal, Ectasia | 1 1 | 3 1.0|
Mediastinal, Hemorrhage | | 2 2.0|
Mediastinal, Hyperplasia | | 2 2.0|
Mediastinal, Infiltration Cellular, | | |
Plasma Cell | 2 | 3 2.0|
Pancreatic, Ectasia | | 2 2.0|
Pancreatic, Hemorrhage | | 1 1.0|
Pancreatic, Inflammation | | 1 3.0|
Renal, Ectasia | | 1 2.0|
Renal, Infiltration Cellular, | | |
Histiocyte | | 1 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M M M M M M M M M M M M M M M M M M M M M M M| |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | 2 | 6 2.0|
Ectasia | 2 1 2 | 4 1.8|
Infiltration Cellular, Histiocyte | 1 1 2 1 3 1 3 1 1 3 1 1 3 2 1 1 1 1 1 1 3 2 | 46 1.5|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 108
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 7| 6| 5| 5| 7| 7| 7| 6| 6| 5| 5| 6| 6| 6| 7| 6| 6| 6| 4| 5| 6| 5| |
DAY ON TEST | 2| 3| 5| 2| 2| 5| 9| 2| 0| 0| 7| 8| 2| 8| 0| 1| 1| 0| 3| 6| 6| 8| 6| 4| 4| |
| 9| 9| 3| 9| 4| 5| 3| 6| 8| 8| 5| 0| 9| 2| 1| 3| 7| 8| 4| 9| 2| 7| 9| 1| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
1250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Fibrosis | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 2 1 1 1 1 2 1 1 1 1 1 2 2 1 1 1 1 1 1 2| 41 1.2|
Hemorrhage | 3 | 1 3.0|
Hyperplasia, Lymphoid | 2 | 4 2.0|
Inflammation, Granulomatous | | 1 4.0|
Necrosis | 2 | 1 2.0|
Pigmentation, Hemosiderin | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1| 43 1.0|
Lymphoid Follicle, Atrophy | | 2 2.5|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Atrophy | 4 3 4 3 4 4 4 4 4 4 3 4 4 4 4 4 4 4 4 4 3 3 4| 46 3.8|
Ectopic Parathyroid Gland | 1 | 4 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrous Osteodystrophy | 2 2 | 4 1.8|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 2 2 2 | 5 2.2|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | 1 1| 7 1.3|
Inflammation, Granulomatous | 1 | 2 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 109
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 7| 6| 5| 5| 7| 7| 7| 6| 6| 5| 5| 6| 6| 6| 7| 6| 6| 6| 4| 5| 6| 5| |
DAY ON TEST | 2| 3| 5| 2| 2| 5| 9| 2| 0| 0| 7| 8| 2| 8| 0| 1| 1| 0| 3| 6| 6| 8| 6| 4| 4| |
| 9| 9| 3| 9| 4| 5| 3| 6| 8| 8| 5| 0| 9| 2| 1| 3| 7| 8| 4| 9| 2| 7| 9| 1| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
1250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Metaplasia, Squamous | | 1 1.0|
Mineralization | 2 3 | 10 2.7|
Alveolar Epithelium, Hyperplasia | 1 | 7 1.3|
Alveolus, Infiltration Cellular, | | |
Histiocyte | 1 2 2 2 2 1 2 2 2 2 2 1 2 2 1 2 1 2 1 2 2 3 2 2 1| 50 1.8|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 2 3 2 2 | 9 1.9|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 2 3 | 3 2.3|
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Anterior Chamber, Inflammation | | 1 3.0|
Cornea, Inflammation | | 1 1.0|
Iris, Inflammation | | 1 2.0|
|__________________________________________________________________________|____________|
Harderian Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 1 1.0|
Infiltration Cellular, Lymphoid | 1 | 3 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accumulation, Hyaline Droplet | 1 | 2 2.5|
Nephropathy | 3 4 4 4 4 2 4 4 4 4 4 4 2 4 2 4 4 4 4 4 4 2 4 4 4| 50 3.8|
Artery, Inflammation | | 1 2.0|
Cortex, Mineralization | 1 3 2 4 1 | 14 2.8|
Medulla, Mineralization | 1 1 1 1 1 1 2 1 1 2 1 1 1 1 1 1 1 1 1 2 1 1 1 1| 49 1.2|
Papilla, Transitional Epithelium, | | |
Hyperplasia | 1 | 1 1.0|
Pelvis, Inflammation | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 110
NTP Experiment-Test: 88138-03 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC BENZOPHENONE Date: 07/21/03
Route: DOSED FEED Time: 15:26:04
__________________________________________________________________________________________________________________________________
| 5| 6| 6| 7| 6| 5| 5| 7| 7| 7| 6| 6| 5| 5| 6| 6| 6| 7| 6| 6| 6| 4| 5| 6| 5| |
DAY ON TEST | 2| 3| 5| 2| 2| 5| 9| 2| 0| 0| 7| 8| 2| 8| 0| 1| 1| 0| 3| 6| 6| 8| 6| 4| 4| |
| 9| 9| 3| 9| 4| 5| 3| 6| 8| 8| 5| 0| 9| 2| 1| 3| 7| 8| 4| 9| 2| 7| 9| 1| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| A |
1250 PPM | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| L |
| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Pelvis, Transitional Epithelium, | | |
Hyperplasia | 2 2 1 2 2 2 2 2 3 2 2 2 1 2 2 2 | 34 1.7|
Renal Tubule, Cyst | X X X | 9 |
Renal Tubule, Hyperplasia | 1 2 2 2 1 3 2 1 1 1 1| 23 1.3|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation | 1 | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
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