TDMS Study 05135-04 Pathology Tables

NTP Experiment-Test: 05135-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: SUBCHRON 90-DAY                                      ISOPRENE                                         Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:08:26
       Facility:  Battelle Northwest
       Chemical CAS #:  78-79-5
       Lock Date:  None
       Cage Range:  All
       Reasons For Removal:    All
       Removal Date Range:     All
       Treatment Groups:       Include All
a  Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05135-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                      ISOPRENE                                         Date: 10/15/04    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:08:26    
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         B6C3F1 MICE FEMALE                        CONTROL      70 PPM       220 PPM      700 PPM      2200 PPM     7000 PPM        
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DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10           10           10           
  Animals Examined Microscopically                    10           10           10           10           10           10           
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 ALIMENTARY SYSTEM                                                                                                                  
   Liver                                              (10)         (1)          (1)          (10)         (10)         (10)         
      Vacuolization Cytoplasmic                                                                                         1 (10%)     
   Stomach, Forestomach                               (10)                                   (10)         (10)         (10)         
      Epithelium, Hyperplasia                                                                10 (100%)     9 (90%)     10 (100%)    
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 CARDIOVASCULAR SYSTEM                                                                                                              
   None                                                                                                                             
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 ENDOCRINE SYSTEM                                                                                                                   
   None                                                                                                                             
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 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
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 GENITAL SYSTEM                                                                                                                     
   Ovary                                              (10)                      (1)                                    (10)         
      Abscess                                          1 (10%)                                                                      
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 HEMATOPOIETIC SYSTEM                                                                                                               
   Lymph Node                                         (1)                                                                           
      Renal, Hyperplasia                               1 (100%)                                                                     
   Spleen                                             (10)         (1)          (1)          (10)         (10)         (10)         
a  Number of animals examined microscopically at site and number of animals with lesion                                             
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NTP Experiment-Test: 05135-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                      ISOPRENE                                         Date: 10/15/04    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:08:26    
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      70 PPM       220 PPM      700 PPM      2200 PPM     7000 PPM        
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Pigmentation, Melanin                                                                   1 (10%)      1 (10%)                  
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 INTEGUMENTARY SYSTEM                                                                                                               
   None                                                                                                                             
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 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
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 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
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 RESPIRATORY SYSTEM                                                                                                                 
   Nose                                               (10)                                                             (10)         
      Turbinate, Inflammation, Suppurative                                                                              1 (10%)     
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 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
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 URINARY SYSTEM                                                                                                                     
   None                                                                                                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
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NTP Experiment-Test: 05135-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                      ISOPRENE                                         Date: 10/15/04    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:08:26    
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      70 PPM       220 PPM      700 PPM      2200 PPM     7000 PPM        
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          10           10           10           10           10           10           
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                10           10           10           10           10           10           
  Animals Examined Microscopically                    10           10           10           10           10           10           
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Liver                                              (10)                      (2)          (10)         (9)          (10)         
      Basophilic Focus                                                           1 (50%)                                            
      Necrosis                                         1 (10%)                                                                      
      Vacuolization Cytoplasmic                                                                            3 (33%)     10 (100%)    
   Stomach, Forestomach                               (10)                      (1)          (9)          (8)          (10)         
      Epithelium, Hyperplasia                                                                 9 (100%)     8 (100%)     9 (90%)     
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 CARDIOVASCULAR SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   None                                                                                                                             
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 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
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 GENITAL SYSTEM                                                                                                                     
   Testes                                             (10)                      (1)          (10)         (9)          (10)         
      Atrophy                                                                                                           2 (20%)     
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 HEMATOPOIETIC SYSTEM                                                                                                               
   Spleen                                             (10)                      (1)          (10)         (9)          (10)         
a  Number of animals examined microscopically at site and number of animals with lesion                                             
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NTP Experiment-Test: 05135-04         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03  
Study Type: SUBCHRON 90-DAY                                      ISOPRENE                                         Date: 10/15/04    
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:08:26    
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      70 PPM       220 PPM      700 PPM      2200 PPM     7000 PPM        
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Pigmentation                                                                                                      1 (10%)     
      Pigmentation, Melanin                                                                                1 (11%)                  
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 INTEGUMENTARY SYSTEM                                                                                                               
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
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 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                               (10)                      (1)          (10)         (9)          (10)         
      Hemorrhage                                       1 (10%)                                                                      
   Nose                                               (10)                                                             (10)         
      Turbinate, Olfactory Epithelium, Degeneration                                                                    10 (100%)    
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 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
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 URINARY SYSTEM                                                                                                                     
   Kidney                                             (10)                      (1)          (10)         (9)          (10)         
      Bilateral, Hydronephrosis                        1 (10%)                                                                      
a  Number of animals examined microscopically at site and number of animals with lesion                                             
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