TDMS Study 05135-04 Pathology Tables
NTP Experiment-Test: 05135-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:08:26
Facility: Battelle Northwest
Chemical CAS #: 78-79-5
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05135-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:08:26
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B6C3F1 MICE FEMALE CONTROL 70 PPM 220 PPM 700 PPM 2200 PPM 7000 PPM
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DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Survivors
Terminal Sacrifice 10 10 10 10 10 10
Animals Examined Microscopically 10 10 10 10 10 10
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ALIMENTARY SYSTEM
Liver (10) (1) (1) (10) (10) (10)
Vacuolization Cytoplasmic 1 (10%)
Stomach, Forestomach (10) (10) (10) (10)
Epithelium, Hyperplasia 10 (100%) 9 (90%) 10 (100%)
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
None
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Ovary (10) (1) (10)
Abscess 1 (10%)
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HEMATOPOIETIC SYSTEM
Lymph Node (1)
Renal, Hyperplasia 1 (100%)
Spleen (10) (1) (1) (10) (10) (10)
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05135-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:08:26
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 70 PPM 220 PPM 700 PPM 2200 PPM 7000 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Pigmentation, Melanin 1 (10%) 1 (10%)
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INTEGUMENTARY SYSTEM
None
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MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
None
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RESPIRATORY SYSTEM
Nose (10) (10)
Turbinate, Inflammation, Suppurative 1 (10%)
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SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05135-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:08:26
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 70 PPM 220 PPM 700 PPM 2200 PPM 7000 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Survivors
Terminal Sacrifice 10 10 10 10 10 10
Animals Examined Microscopically 10 10 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (2) (10) (9) (10)
Basophilic Focus 1 (50%)
Necrosis 1 (10%)
Vacuolization Cytoplasmic 3 (33%) 10 (100%)
Stomach, Forestomach (10) (1) (9) (8) (10)
Epithelium, Hyperplasia 9 (100%) 8 (100%) 9 (90%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Testes (10) (1) (10) (9) (10)
Atrophy 2 (20%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Spleen (10) (1) (10) (9) (10)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05135-04 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY ISOPRENE Date: 10/15/04
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:08:26
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 70 PPM 220 PPM 700 PPM 2200 PPM 7000 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Pigmentation 1 (10%)
Pigmentation, Melanin 1 (11%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (1) (10) (9) (10)
Hemorrhage 1 (10%)
Nose (10) (10)
Turbinate, Olfactory Epithelium, Degeneration 10 (100%)
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SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (1) (10) (9) (10)
Bilateral, Hydronephrosis 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
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