TDMS Study 97013-96 Pathology Tables
NTP Experiment-Test: 97013-96 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: 26-39 WEEKS WITH AVERAGE SEVERITY GRADES[b] Date: 10/08/03
Route: DOSED WATER WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 15:33:20
FINAL/MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 75-27-4
Lock Date: 07/19/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 1
NTP Experiment-Test: 97013-96 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: 26-39 WEEKS WITH AVERAGE SEVERITY GRADES[b] Date: 10/08/03
Route: DOSED WATER WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 15:33:20
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) FEMALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10
Early Deaths
Moribund Sacrifice 1 1 1
Natural Death 1
Survivors
Terminal Sacrifice 9 9 10 8
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10)
Hematopoietic Cell Proliferation 2 [1.0] 1 [3.0] 1 [2.0]
Infiltration Cellular 1 [1.0]
Infiltration Cellular, Lymphocyte 2 [2.0] 4 [1.0] 4 [1.5] 2 [1.0]
Inflammation 8 [1.0] 7 [1.0] 8 [1.0] 7 [1.0]
Necrosis 3 [1.0] 2 [1.0] 1 [1.0] 1 [2.0]
Hepatocyte, Fatty Change 2 [1.0] 2 [1.0] 3 [1.0] 6 [1.7]
Hepatocyte, Vacuolization Cytoplasmic 9 [1.6] 9 [1.4] 10 [1.6] 8 [1.8]
Serosa, Inflammation 1 [1.0]
Mesentery (1) (1)
Inflammation 1 [2.0]
Fat, Necrosis 1 [4.0]
Salivary Glands (1)
Atrophy 1 [2.0]
Stomach, Forestomach (10) (10) (10) (10)
Hyperkeratosis 1 [2.0] 2 [1.0]
Inflammation 1 [1.0]
Epithelium, Hyperplasia 2 [1.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Subcapsular, Hyperplasia 9 [1.0] 10 [1.0] 10 [1.0] 8 [1.1]
Pituitary Gland (10) (10) (10) (10)
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 2
NTP Experiment-Test: 97013-96 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: 26-39 WEEKS WITH AVERAGE SEVERITY GRADES[b] Date: 10/08/03
Route: DOSED WATER WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 15:33:20
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) FEMALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Cyst 1 [1.0]
Hyperplasia 1 [1.0]
Pars Intermedia, Hyperplasia 1 [2.0]
Thyroid Gland (10) (10) (10) (10)
Inflammation 1 [2.0]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (10) (9) (10) (10)
Angiectasis 1 [1.0]
Atrophy 1 [2.0]
Cyst 3 [1.0] 2 [1.0] 1 [1.0] 2 [1.5]
Uterus (10) (10) (10) (10)
Inflammation 2 [1.0] 1 [1.0] 2 [1.0] 1 [1.0]
Endometrium, Hyperplasia, Cystic 8 [1.6] 8 [1.5] 8 [1.8] 6 [1.8]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (1) (2)
Mediastinal, Infiltration Cellular, Plasma
Cell 1 [3.0]
Lymph Node, Mandibular (10) (10) (10) (9)
Atrophy 1 [3.0]
Hematopoietic Cell Proliferation 1 [1.0]
Hyperplasia, Atypical 1 [2.0]
Lymph Node, Mesenteric (10) (10) (10) (10)
Atrophy 1 [3.0]
Hematopoietic Cell Proliferation 1 [1.0] 1 [2.0]
Spleen (10) (10) (10) (10)
Atrophy 1 [4.0]
Hematopoietic Cell Proliferation 2 [2.0] 1 [4.0] 2 [2.0]
Thymus (10) (9) (10) (10)
Atrophy 2 [2.5] 1 [2.0] 2 [3.5]
Cyst 7 [1.4] 6 [1.2] 8 [1.3] 8 [1.0]
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 3
NTP Experiment-Test: 97013-96 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: 26-39 WEEKS WITH AVERAGE SEVERITY GRADES[b] Date: 10/08/03
Route: DOSED WATER WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 15:33:20
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) FEMALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (1)
Ulcer 1 [3.0]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10)
Hemorrhage 1 [2.0]
Infiltration Cellular, Lymphocyte 1 [2.0] 1 [1.0]
Infiltration Cellular, Histiocyte 1 [2.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
Accumulation, Hyaline Droplet 1 [1.0]
Casts Protein 8 [1.0] 1 [1.0] 5 [1.0] 3 [1.0]
Infiltration Cellular, Lymphocyte 1 [1.0] 4 [1.0] 1 [1.0]
Mineralization 1 [2.0]
Nephropathy 3 [1.0] 1 [3.0] 8 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 4
NTP Experiment-Test: 97013-96 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: 26-39 WEEKS WITH AVERAGE SEVERITY GRADES[b] Date: 10/08/03
Route: DOSED WATER WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 15:33:20
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) MALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10
Early Deaths
Moribund Sacrifice 1 3
Natural Death 1
Survivors
Terminal Sacrifice 9 10 9 7
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (1)
Muscularis, Degeneration 1 [1.0]
Liver (10) (10) (10) (10)
Atypia Cellular 1 [2.0]
Clear Cell Focus 1
Hematopoietic Cell Proliferation 1 [1.0]
Infiltration Cellular, Lymphocyte 1 [1.0] 2 [1.0]
Inflammation 9 [1.0] 5 [1.0] 7 [1.0] 6 [1.0]
Necrosis 2 [1.5]
Hepatocyte, Fatty Change 8 [1.1] 4 [1.0] 3 [1.3] 4 [1.0]
Hepatocyte, Vacuolization Cytoplasmic 9 [3.9] 10 [3.6] 10 [2.8] 9 [2.4]
Salivary Glands (2)
Inflammation 2 [1.0]
Stomach, Forestomach (10) (10) (10) (10)
Inflammation 1 [1.0]
Epithelium, Hyperplasia 1 [2.0] 1 [2.0] 1 [1.0] 1 [2.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Hyperplasia 1 [1.0]
Hypertrophy 2 [1.0] 4 [1.3] 2 [1.0]
Subcapsular, Hyperplasia 2 [1.0] 2 [1.0] 3 [1.0] 2 [1.0]
Islets, Pancreatic (1)
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 5
NTP Experiment-Test: 97013-96 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: 26-39 WEEKS WITH AVERAGE SEVERITY GRADES[b] Date: 10/08/03
Route: DOSED WATER WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 15:33:20
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) MALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hyperplasia 1 [2.0]
Parathyroid Gland (1)
Cyst 1 [2.0]
Pituitary Gland (10) (9) (10) (10)
Cyst 4 [1.0] 3 [1.3] 3 [1.0] 3 [1.0]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Testes (10) (10) (10) (10)
Mineralization 1 [1.0]
Germinal Epithelium, Degeneration 2 [1.0] 2 [1.5] 1 [1.0] 3 [1.0]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (10) (10) (10) (10)
Atrophy 1 [2.0]
Lymph Node, Mesenteric (10) (10) (10) (10)
Atrophy 1 [2.0] 2 [2.0]
Spleen (10) (10) (10) (10)
Atrophy 3 [2.0]
Hematopoietic Cell Proliferation 1 [2.0]
Thymus (10) (10) (10) (10)
Atrophy 1 [2.0] 3 [3.3]
Cyst 8 [1.0] 7 [1.3] 3 [1.0] 4 [1.3]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 6
NTP Experiment-Test: 97013-96 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: 26-39 WEEKS WITH AVERAGE SEVERITY GRADES[b] Date: 10/08/03
Route: DOSED WATER WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Time: 15:33:20
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) MALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10)
Alveolar Epithelium, Hyperplasia 1 [1.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (1)
Inflammation 1 [2.0]
Lacrimal Gland (1) (1)
Inflammation 1 [2.0] 1 [2.0]
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
Casts Protein 1 [1.0]
Hydronephrosis 1 [1.0] 1 [1.0]
Infiltration Cellular, Lymphocyte 1 [2.0]
Mineralization 1 [2.0] 1 [3.0]
Nephropathy 5 [1.0] 4 [1.0] 9 [1.2] 8 [1.4]
Renal Tubule, Degeneration 6 [2.2] 10 [2.4]
Renal Tubule, Dilatation 1 [1.0] 3 [1.0] 2 [1.0]
Renal Tubule, Necrosis 1 [1.0]
Renal Tubule, Vacuolization Cytoplasmic 10 [1.6] 5 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 7
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