TDMS Study 88004-05 Pathology Tables
NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:35:06
FINAL #1 RATS
Facility: Battelle Northwest
Chemical CAS #: 1321-74-0
Lock Date: 04/16/02
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:35:06
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 10 16 14 26
Natural Death 7 3 3 2
Accidently Killed 1
Survivors
Terminal Sacrifice 33 30 33 22
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (49) (49) (50)
Epithelium, Metaplasia, Focal, Squamous 1 (2%)
Liver (50) (50) (50) (50)
Clear Cell Focus 5 (10%) 7 (14%) 6 (12%)
Hepatodiaphragmatic Nodule 5 (10%) 7 (14%) 6 (12%) 9 (18%)
Necrosis 1 (2%)
Vacuolization Cytoplasmic 4 (8%) 3 (6%) 3 (6%)
Bile Duct, Hyperplasia 1 (2%)
Hepatocyte, Regeneration 1 (2%) 1 (2%)
Periportal, Inflammation, Chronic 3 (6%) 2 (4%) 1 (2%) 2 (4%)
Portal, Bile Stasis 1 (2%) 3 (6%) 2 (4%) 1 (2%)
Serosa, Fibrosis 1 (2%)
Mesentery (15) (20) (17) (6)
Necrosis 14 (93%) 20 (100%) 16 (94%) 6 (100%)
Oral Mucosa (1)
Pharyngeal, Ulcer 1 (100%)
Pancreas (50) (49) (50) (50)
Acinus, Atrophy 3 (6%) 5 (10%) 2 (4%) 4 (8%)
Salivary Glands (50) (50) (50) (50)
Inflammation, Chronic 1 (2%)
Stomach, Forestomach (50) (50) (49) (49)
Hyperplasia, Focal, Squamous 1 (2%) 1 (2%)
Ulcer 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Stomach, Glandular (50) (50) (49) (49)
Erosion 1 (2%) 1 (2%)
Ulcer 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Tongue (1) (1) (3) (3)
Epithelium, Hyperplasia 1 (100%) 3 (100%) 2 (67%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:35:06
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Tooth (1)
Peridontal Tissue, Inflammation 1 (100%)
Pulp, Inflammation, Suppurative 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Cardiomyopathy 3 (6%)
Atrium, Thrombosis 1 (2%) 2 (4%)
Pericardium, Infiltration Cellular, Lymphoid 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Accessory Adrenal Cortical Nodule 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia 1 (2%)
Necrosis 1 (2%)
Vacuolization Cytoplasmic 14 (28%) 5 (10%) 7 (14%) 12 (24%)
Adrenal Medulla (50) (50) (50) (50)
Hyperplasia 1 (2%) 1 (2%) 5 (10%) 2 (4%)
Parathyroid Gland (49) (49) (47) (49)
Hyperplasia 1 (2%)
Pituitary Gland (50) (50) (50) (50)
Cyst 6 (12%) 6 (12%) 1 (2%) 5 (10%)
Pars Distalis, Angiectasis 1 (2%)
Pars Distalis, Hematocyst 1 (2%)
Pars Distalis, Hyperplasia 4 (8%) 8 (16%) 4 (8%) 7 (14%)
Thyroid Gland (50) (50) (50) (50)
Ultimobranchial Cyst 1 (2%)
C-Cell, Hyperplasia 5 (10%) 8 (16%) 6 (12%) 1 (2%)
Follicular Cell, Hyperplasia 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:35:06
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Clitoral Gland (50) (50) (50) (50)
Cyst 3 (6%) 1 (2%)
Hyperplasia 1 (2%) 3 (6%) 2 (4%) 2 (4%)
Inflammation, Chronic 2 (4%) 1 (2%) 1 (2%)
Ovary (50) (50) (50) (50)
Cyst 5 (10%) 6 (12%) 11 (22%) 4 (8%)
Bilateral, Cyst 1 (2%)
Uterus (50) (50) (50) (50)
Hemorrhage 1 (2%)
Necrosis 1 (2%)
Endometrium, Hyperplasia 2 (4%) 1 (2%) 1 (2%) 2 (4%)
Myometrium, Hyperplasia 1 (2%)
Vagina (2) (3)
Inflammation, Suppurative 1 (50%)
Muscularis, Hypertrophy 1 (33%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Myelofibrosis 1 (2%)
Lymph Node (6) (10) (9) (8)
Deep Cervical, Infiltration Cellular,
Histiocyte 3 (30%) 1 (13%)
Pancreatic, Pigmentation 1 (10%) 1 (11%)
Lymph Node, Bronchial (8) (9) (5) (14)
Infiltration Cellular, Histiocyte 1 (7%)
Lymph Node, Mesenteric (50) (50) (50) (50)
Infiltration Cellular, Histiocyte 2 (4%) 1 (2%) 2 (4%)
Pigmentation 1 (2%)
Lymph Node, Mediastinal (32) (37) (44) (34)
Fibrosis 1 (2%)
Hyperplasia, Lymphoid 1 (3%) 1 (2%)
Infiltration Cellular, Histiocyte 2 (6%) 1 (3%)
Inflammation, Suppurative 1 (3%)
Spleen (50) (50) (50) (50)
Accessory Spleen 2 (4%) 1 (2%) 1 (2%)
Fibrosis 3 (6%) 1 (2%) 3 (6%) 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hemorrhage 2 (4%) 1 (2%) 1 (2%) 2 (4%)
Hyperplasia, Focal, Lymphoid 2 (4%)
Inflammation, Chronic Active 1 (2%)
Necrosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:35:06
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Thymus (45) (41) (46) (39)
Cyst 1 (3%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Galactocele 1 (2%) 2 (4%)
Hyperplasia 1 (2%)
Inflammation, Chronic 1 (2%)
Skin (50) (50) (50) (50)
Cyst Epithelial Inclusion 2 (4%) 1 (2%)
Hyperkeratosis 1 (2%)
Inflammation, Granulomatous 1 (2%)
Ulcer 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Joint, Fracture 1 (2%)
Tibia, Fracture 1 (2%)
Skeletal Muscle (2) (3) (7) (5)
Inflammation, Chronic 1 (33%)
Necrosis 1 (50%) 1 (33%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Compression 9 (18%) 10 (20%) 11 (22%) 7 (14%)
Congestion 1 (2%)
Hemorrhage 2 (4%) 2 (4%) 6 (12%) 3 (6%)
Infarct 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (50) (49) (50)
Foreign Body 1 (2%) 3 (6%)
Inflammation, Suppurative 2 (4%) 1 (2%)
Epiglottis, Metaplasia, Squamous 1 (2%)
Lung (50) (50) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:35:06
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Atrophy 1 (2%)
Cyst 1 (2%)
Foreign Body 1 (2%)
Hemorrhage 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic, Diffuse 1 (2%) 1 (2%)
Inflammation, Chronic, Focal 27 (54%) 22 (44%) 26 (52%) 33 (66%)
Alveolar Epithelium, Hyperplasia 4 (8%) 2 (4%) 3 (6%) 1 (2%)
Alveolar Epithelium, Hypertrophy 1 (2%) 1 (2%) 1 (2%)
Alveolus, Infiltration Cellular, Focal,
Histiocyte 8 (16%) 3 (6%) 6 (12%) 5 (10%)
Interstitium, Fibrosis 1 (2%)
Mediastinum, Necrosis, Fatty 1 (2%)
Nose (50) (50) (49) (49)
Foreign Body 1 (2%) 5 (10%) 1 (2%)
Inflammation, Suppurative 5 (10%) 12 (24%) 8 (16%) 7 (14%)
Ulcer 1 (2%)
Glands, Dilatation 17 (34%) 38 (78%) 44 (90%)
Goblet Cell, Hyperplasia 1 (2%) 3 (6%) 1 (2%) 4 (8%)
Nasolacrimal Duct, Inflammation, Suppurative 3 (6%) 1 (2%) 3 (6%) 1 (2%)
Nasopharyngeal Duct, Inflammation,
Suppurative 1 (2%)
Olfactory Epithelium, Degeneration 50 (100%) 49 (100%) 48 (98%)
Olfactory Epithelium, Degeneration, Hyaline 10 (20%) 14 (28%) 15 (31%) 4 (8%)
Olfactory Epithelium, Hyperplasia, Basal Cell 25 (50%) 42 (86%) 45 (92%)
Olfactory Epithelium, Regeneration, Focal 1 (2%)
Respiratory Epithelium, Degeneration, Hyaline 5 (10%) 3 (6%) 4 (8%)
Respiratory Epithelium, Hyperplasia 1 (2%) 1 (2%)
Respiratory Epithelium, Metaplasia, Squamous 1 (2%)
Pleura (50) (50) (50) (49)
Fibrosis 1 (2%)
Infiltration Cellular, Lymphoid 1 (2%)
Trachea (50) (50) (50) (50)
Glands, Degeneration, Cystic 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (50) (48) (49) (49)
Atrophy 1 (2%)
Inflammation, Chronic 1 (2%)
Anterior Chamber, Hemorrhage 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:35:06
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM - CONT
Ciliary Body, Inflammation 1 (2%)
Cornea, Inflammation 1 (2%)
Lens, Cataract 1 (2%) 3 (6%) 4 (8%) 1 (2%)
Harderian Gland (50) (50) (50) (50)
Inflammation, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (49) (50)
Cyst 1 (2%)
Nephropathy, Chronic 19 (38%) 21 (42%) 19 (39%) 10 (20%)
Bilateral, Cortex, Renal Tubule, Degeneration 1 (2%)
Cortex, Infarct 2 (4%)
Cortex, Renal Tubule, Accumulation, Hyaline
Droplet 1 (2%)
Cortex, Renal Tubule, Hyperplasia 1 (2%) 1 (2%)
Medulla, Renal Tubule, Degeneration 1 (2%)
Pelvis, Transitional Epithelium, Hyperplasia 1 (2%) 1 (2%)
Pelvis, Transitional Epithelium,
Mineralization 1 (2%)
Renal Tubule, Dilatation 1 (2%)
Urinary Bladder (50) (50) (49) (49)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:35:06
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 15 9 12 13
Natural Death 4 6 6 5
Survivors
Terminal Sacrifice 31 35 31 32
Natural Death 1
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (50) (50)
Foreign Body 1 (2%)
Intestine Small, Jejunum (46) (47) (47) (46)
Necrosis 1 (2%)
Intestine Small, Ileum (46) (47) (45) (46)
Dilatation 1 (2%)
Liver (50) (49) (50) (50)
Angiectasis 1 (2%) 1 (2%)
Clear Cell Focus 2 (4%) 5 (10%) 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
Hepatodiaphragmatic Nodule 2 (4%) 2 (4%) 4 (8%) 8 (16%)
Inflammation, Granulomatous 1 (2%)
Necrosis 1 (2%) 1 (2%) 3 (6%) 2 (4%)
Vacuolization Cytoplasmic 1 (2%) 2 (4%) 3 (6%) 3 (6%)
Bile Duct, Hyperplasia 3 (6%)
Hepatocyte, Regeneration 1 (2%)
Periportal, Inflammation, Chronic 2 (4%)
Serosa, Fibrosis 1 (2%) 1 (2%)
Serosa, Hemorrhage 1 (2%)
Mesentery (12) (13) (18) (11)
Necrosis 7 (58%) 13 (100%) 18 (100%) 9 (82%)
Fat, Hemorrhage 1 (9%)
Oral Mucosa (1) (1) (4)
Gingival, Cyst 1 (25%)
Gingival, Hyperplasia, Squamous 1 (100%)
Pancreas (50) (49) (50) (50)
Thrombosis 1 (2%)
Acinus, Atrophy 15 (30%) 18 (37%) 27 (54%) 21 (42%)
Acinus, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:35:06
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Acinus, Inflammation 1 (2%)
Duct, Cyst 1 (2%) 2 (4%) 3 (6%)
Stomach, Forestomach (50) (48) (50) (50)
Diverticulum 1 (2%)
Hyperplasia, Squamous 1 (2%)
Inflammation, Suppurative 1 (2%)
Ulcer 4 (8%) 1 (2%) 1 (2%)
Stomach, Glandular (50) (48) (50) (49)
Erosion 2 (4%) 2 (4%) 2 (4%)
Ulcer 1 (2%) 2 (4%) 1 (2%)
Epithelium, Hyperplasia 1 (2%)
Tongue (1) (1)
Epithelium, Hyperplasia 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (50) (50) (50) (50)
Thrombosis 1 (2%)
Heart (50) (50) (50) (50)
Cardiomyopathy 7 (14%) 5 (10%) 1 (2%) 1 (2%)
Atrium, Thrombosis 2 (4%) 1 (2%) 2 (4%) 1 (2%)
Pericardium, Inflammation 1 (2%)
Pericardium, Pigmentation 1 (2%)
Pericardium, Epicardium, Infiltration
Cellular, Histiocyte 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Hyperplasia 1 (2%) 2 (4%)
Necrosis 2 (4%)
Vacuolization Cytoplasmic 8 (16%) 8 (16%) 7 (14%) 6 (12%)
Adrenal Medulla (50) (50) (50) (50)
Hyperplasia 12 (24%) 13 (26%) 8 (16%) 14 (28%)
Bilateral, Hyperplasia 1 (2%)
Islets, Pancreatic (50) (48) (50) (50)
Hyperplasia 1 (2%) 1 (2%) 2 (4%) 2 (4%)
Parathyroid Gland (46) (48) (49) (47)
Hyperplasia 1 (2%) 1 (2%)
Pituitary Gland (50) (50) (50) (49)
Cyst 1 (2%) 1 (2%) 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:35:06
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hemorrhage 1 (2%) 1 (2%)
Pars Distalis, Hematocyst 1 (2%)
Pars Distalis, Hyperplasia 5 (10%) 8 (16%) 9 (18%) 8 (16%)
Thyroid Gland (50) (50) (50) (49)
C-Cell, Hyperplasia 2 (4%) 4 (8%) 9 (18%) 7 (14%)
Follicular Cell, Hyperplasia 2 (4%) 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Penis (2)
Inflammation 1 (50%)
Preputial Gland (48) (50) (50) (49)
Cyst 1 (2%) 1 (2%) 2 (4%) 1 (2%)
Hyperplasia 1 (2%) 4 (8%) 1 (2%) 1 (2%)
Prostate (50) (50) (50) (50)
Hyperplasia 1 (2%)
Inflammation, Suppurative 5 (10%) 1 (2%) 4 (8%) 2 (4%)
Seminal Vesicle (50) (49) (50) (50)
Dilatation 1 (2%)
Hyperplasia 1 (2%)
Inflammation, Suppurative 1 (2%)
Testes (50) (50) (50) (50)
Artery, Inflammation, Chronic Active 2 (4%)
Germinal Epithelium, Atrophy 16 (32%) 12 (24%) 11 (22%) 9 (18%)
Interstitial Cell, Hyperplasia 7 (14%) 6 (12%) 2 (4%) 3 (6%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (11) (5) (11) (6)
Deep Cervical, Angiectasis 1 (9%) 1 (17%)
Deep Cervical, Cyst 1 (20%)
Deep Cervical, Hemorrhage 1 (9%)
Deep Cervical, Hyperplasia, Lymphoid 1 (9%)
Pancreatic, Ectasia 1 (9%)
Pancreatic, Hemorrhage 1 (17%)
Pancreatic, Infiltration Cellular, Histiocyte 1 (9%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:35:06
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Lymph Node, Bronchial (7) (6) (12) (5)
Hemorrhage 1 (20%)
Infiltration Cellular 1 (20%)
Pigmentation 1 (20%)
Lymph Node, Mesenteric (49) (49) (50) (50)
Angiectasis 1 (2%)
Ectasia 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%) 1 (2%) 3 (6%)
Lymph Node, Mediastinal (19) (23) (25) (38)
Angiectasis 1 (3%)
Hyperplasia, Lymphoid 1 (3%)
Spleen (50) (49) (50) (50)
Accessory Spleen 3 (6%) 1 (2%)
Fibrosis 2 (4%) 6 (12%) 4 (8%) 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hemorrhage 2 (4%) 1 (2%) 1 (2%)
Hyperplasia, Focal, Lymphoid 1 (2%)
Necrosis 3 (6%) 1 (2%) 1 (2%) 1 (2%)
Lymphocyte, Hyperplasia, Diffuse 1 (2%)
Thymus (48) (44) (46) (42)
Hemorrhage 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (35) (43) (47) (48)
Galactocele 3 (9%) 2 (5%) 6 (13%) 3 (6%)
Skin (50) (50) (50) (50)
Cyst Epithelial Inclusion 4 (8%) 1 (2%) 3 (6%) 2 (4%)
Hyperkeratosis 2 (4%) 1 (2%) 2 (4%)
Inflammation, Acute 2 (4%)
Inflammation, Granulomatous 1 (2%)
Ulcer 2 (4%)
Subcutaneous Tissue, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Hyperostosis 1 (2%)
Cartilage, Femur, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:35:06
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - CONT
Femur, Fracture 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (49) (50) (50) (50)
Compression 10 (20%) 5 (10%) 8 (16%) 6 (12%)
Gliosis 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (49) (49) (50) (49)
Foreign Body 1 (2%) 2 (4%) 3 (6%) 2 (4%)
Inflammation, Suppurative 1 (2%) 1 (2%) 1 (2%)
Epiglottis, Metaplasia, Squamous 1 (2%) 1 (2%)
Lung (50) (50) (50) (50)
Congestion 1 (2%)
Hemorrhage 2 (4%) 1 (2%) 4 (8%) 4 (8%)
Inflammation, Chronic 1 (2%)
Inflammation, Chronic, Diffuse 1 (2%)
Inflammation, Chronic, Focal 4 (8%) 4 (8%) 5 (10%) 14 (28%)
Inflammation, Suppurative 1 (2%)
Necrosis 1 (2%) 1 (2%)
Thrombosis 1 (2%)
Alveolar Epithelium, Hyperplasia 4 (8%) 8 (16%) 6 (12%) 6 (12%)
Alveolar Epithelium, Hypertrophy 1 (2%) 1 (2%) 2 (4%)
Alveolus, Hypertrophy 1 (2%)
Alveolus, Infiltration Cellular, Focal,
Histiocyte 9 (18%) 12 (24%) 11 (22%) 4 (8%)
Interstitium, Fibrosis 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Mediastinum, Abscess 1 (2%)
Mediastinum, Inflammation, Chronic 1 (2%)
Mediastinum, Pigmentation 1 (2%)
Perivascular, Edema 1 (2%)
Perivascular, Infiltration Cellular,
Eosinophil 1 (2%)
Nose (50) (48) (50) (49)
Foreign Body 5 (10%) 1 (2%) 3 (6%)
Inflammation, Suppurative 5 (10%) 9 (19%) 17 (34%) 10 (20%)
Glands, Dilatation 3 (6%) 30 (63%) 48 (96%) 46 (94%)
Goblet Cell, Hyperplasia 1 (2%) 3 (6%) 7 (14%) 16 (33%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:35:06
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 100 PPM 200 PPM 400 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Nasolacrimal Duct, Inflammation, Suppurative 2 (4%) 6 (13%) 1 (2%) 4 (8%)
Nasopharyngeal Duct, Cyst 1 (2%)
Nasopharyngeal Duct, Foreign Body 1 (2%)
Nasopharyngeal Duct, Inflammation,
Suppurative 1 (2%)
Nasopharyngeal Duct, Respiratory Epithelium,
Hyperplasia 1 (2%)
Olfactory Epithelium, Degeneration 47 (98%) 49 (98%) 49 (100%)
Olfactory Epithelium, Degeneration, Hyaline 4 (8%) 2 (4%) 1 (2%)
Olfactory Epithelium, Hyperplasia, Basal Cell 21 (44%) 44 (88%) 48 (98%)
Olfactory Epithelium, Metaplasia 1 (2%) 2 (4%)
Respiratory Epithelium, Hyperplasia 1 (2%)
Turbinate, Cyst 1 (2%)
Pleura (50) (50) (50) (50)
Mesothelium, Hyperplasia 1 (2%)
Trachea (50) (49) (50) (49)
Glands, Degeneration, Cystic 1 (2%) 5 (10%)
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SPECIAL SENSES SYSTEM
Eye (50) (48) (48) (49)
Anterior Chamber, Hemorrhage 1 (2%)
Cornea, Mineralization 1 (2%)
Lens, Cataract 2 (4%) 1 (2%) 3 (6%) 1 (2%)
Retina, Atrophy 1 (2%)
Harderian Gland (50) (50) (50) (50)
Atrophy 1 (2%)
Zymbal's Gland (1) (3)
Inflammation, Suppurative 1 (33%)
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URINARY SYSTEM
Kidney (50) (49) (50) (49)
Cyst 1 (2%) 1 (2%)
Nephropathy, Chronic 37 (74%) 41 (84%) 41 (82%) 45 (92%)
Cortex, Infarct 1 (2%) 1 (2%)
Cortex, Renal Tubule, Degeneration 1 (2%)
Cortex, Renal Tubule, Hyperplasia 1 (2%) 2 (4%) 2 (4%)
Cortex, Renal Tubule, Hypertrophy 1 (2%)
Medulla, Infarct 1 (2%)
Medulla, Infiltration Cellular, Lipocyte 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC DIVINYLBENZENE Date: 12/17/03
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 11:35:06
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FISCHER 344 RATS MALE CONTROL 100 PPM 200 PPM 400 PPM
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URINARY SYSTEM - CONT
Papilla, Renal Tubule, Dilatation 1 (2%)
Pelvis, Transitional Epithelium, Hyperplasia 1 (2%) 1 (2%)
Pelvis, Transitional Epithelium,
Mineralization 1 (2%)
Urethra (1)
Transitional Epithelium, Hyperplasia 1 (100%)
Urinary Bladder (50) (49) (50) (49)
Calculus Micro Observation Only 4 (8%) 2 (4%) 4 (8%) 4 (8%)
Hemorrhage 2 (4%) 1 (2%) 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
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